methacholine chloride has been researched along with Disease Models, Animal in 331 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 5 (1.51) | 18.7374 |
1990's | 52 (15.71) | 18.2507 |
2000's | 138 (41.69) | 29.6817 |
2010's | 121 (36.56) | 24.3611 |
2020's | 15 (4.53) | 2.80 |
Authors | Studies |
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Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
Choi, JH; Kim, JY; Kim, M; Yi, MH; Yong, TS | 1 |
Ather, JL; Barup, MLT; Mank, MM; Poynter, ME; Reed, LF; Walton, CJ | 1 |
Henry, PJ; Landwehr, KR; Larcombe, AN; Mann, TS; Noble, PB; Shamsuddin, D; Wang, KCW | 1 |
Takeda, K | 1 |
Feng, Y; Li, L; Li, Z; Liu, L; Ma, S; Wang, J; Wang, X; Wang, Z; Yang, K; Zhu, Y; Zhu, Z | 1 |
Einisman, HJ; Gaston, B; Lewis, SJ; Lewis, TH; Raffay, TM; Smith, LA; Wijers, C | 1 |
Azimi, S; Hall, IP; Henry, AP; Kotlikoff, MI; Lee, FK; Lee, JC; Liu, B; Miller, S; Probert, K; Sayers, I | 1 |
Kaczyńska, K; Russjan, E | 1 |
Dong, L; Liu, SF; Nie, Q; Niu, Y; Song, D; Song, W; Wang, X; Wu, G; Zhang, J | 1 |
Bowser, JE; Byars, P; Byrne, R; Hunter, CL; Moore, JW; Swiderski, CE; Wills, RW; Wilson, RM | 1 |
Contaifer, D; Dileepan, M; Ge, XN; Greenberg, YG; Ha, SG; Rao, SP; Rastle-Simpson, S; Sriramarao, P; Wijesinghe, DS | 1 |
Hirai, K; Homma, T; Ida, H; Jinno, M; Kashima, A; Kimura, T; Miyata, Y; Ohta, S; Sagara, H; Sato, H; Suganuma, H; Suzuki, S; Tanaka, A; Uno, T; Watanabe, Y; Yamamoto, M | 1 |
Chan, WM; Chen, J; Ko, KM; Leong, PK; Leung, HY; Yan, CTM | 1 |
Kiskurno, S; Kumar, VH; Paturi, B; Ryan, RM; Wang, H | 1 |
Cui, J; Dong, J; Dong, M; Qin, J; Tang, W; Teng, F; Wang, S; Wang, W; Wei, Y; Wuniqiemu, T; Zhu, X | 1 |
Abma, W; Adner, M; Alvarado-Vazquez, PA; Feyerabend, TB; Hallgren, J; Janson, C; Malinovschi, A; Mendez-Enriquez, E; Rodewald, HR; Rodin, S; Simonson, OE | 1 |
Babik, B; Balogh, AL; Fodor, GH; Ivankovitsne-Kiss, O; Petak, F; Sudy, R | 1 |
Baudat, A; Bayat, S; Doras, C; Eigenmann, P; Habre, W; Petak, F; Von Garnier, C | 1 |
Eslami-Behroozi, M; Javan, M; Raoufy, MR | 1 |
Abo, M; Fujimura, M; Hara, J; Kasahara, K; Katayama, N; Nakao, S; Ohkura, N; Okazaki, A; Sakai, T | 1 |
Fu, T; Han, L; Sheng, B; Wang, L; Zeng, Q; Zhang, Y | 1 |
Abel, PW; Aggarwal, A; Bockman, CS; Deodhar, M; Hallgren, J; Iyer, SH; Kansal, V; Matthews, SA; Netzel, L; Oldenburg, PJ; Simeone, KA; Simeone, TA | 1 |
Boskabady, MH; Eftekhar, N; Moghimi, A | 1 |
Cavalcante, FSÁ; Gomes, MDM; Leal-Cardoso, JH; Serra, DS | 1 |
Albu, G; Bayat, S; Broche, L; Dégrugilliers, L; Fodor, GH; Habre, W; Peták, F; Porra, L; Sovijärvi, ARA; Strengell, S; Suhonen, H; Suortti, P | 1 |
Bourque, G; Chiwara, V; de Sanctis, JB; Ho, B; Jeannotte, L; Kanagaratham, C; Moussette, S; Naumova, AK; Radzioch, D; Venuto, D; Youssef, M | 1 |
Ilka, F; Javan, M; Raoufy, MR | 1 |
Altieri, A; Basu, S; Halayko, AJ; Hemshekhar, M; Hiemstra, PS; Mookherjee, N; Piyadasa, H; van der Does, AM | 1 |
Aierken, A; Xu, P | 1 |
Chen, CM; Chiang, BL; Chou, HC; Lin, SC | 1 |
Hur, J; Kang, JY; Kim, IK; Kim, YK; Lee, J; Lee, JH; Lee, SY; Rhee, CK; Yoon, HJ; Yoon, HK | 1 |
Alipour, MR; Aslani, MR; Boskabady, MH; Ghobadi, H; Keyhanmanesh, R | 1 |
Britt, RD; Faksh, A; Fang, YH; Freeman, MR; Kuipers, I; Manlove, LJ; Pabelick, CM; Prakash, YS; Thompson, MA; Vogel, ER; Yang, B | 1 |
Gounni, AS; Halayko, AJ; Mohammed, A; Movassagh, H; Ojo, OO; Shan, L | 1 |
de Beer, R; de Vos, AF; Morgan, BP; Ramirez Moral, I; Roelofs, JJTH; van 't Veer, C; van der Poll, T; Yang, J | 1 |
Gauvreau, GM; Grasemann, H; Inman, MD; Khanna, N; North, ML; Scott, JA | 1 |
Chen, L; Deng, Z; Gao, ZC; Ge, HQ; Pu, XP; Sun, SY; Wu, DY; Zhang, LR; Zhou, JJ; Zhu, ZP | 1 |
Hartney, JM; Robichaud, A | 1 |
Bailey, S; Bourke, JE; Donovan, C; Esposito, J; Ibrahim, ZA; Royce, SG; Tang, ML; Tran, J | 1 |
Fei, F; Gong, D; Groffen, J; Heisterkamp, N; Lim, M; Yu, M | 1 |
Chen, L; Lai, K; Zhong, N | 1 |
Amria, M; Bell, PD; Bunni, MA; Estell, KP; Flume, P; Gilley, SK; Gooz, M; Haycraft, CJ; Miller, C; Pasek, RC; Pavlik, JA; Sas, KM; Schwiebert, LM; Sisson, JH; Steele, SL; Stenbit, AE; Turner, GA; Yoder, BK | 1 |
Carlier, V; De Vooght, V; Devos, FC; Haenen, S; Hoet, PH; Nemery, B; Vanoirbeek, JA; Verbeken, E | 1 |
Aliyeva, M; Anathy, V; Daphtary, N; Dixon, AE; Goldman, DH; Hoffman, SM; Irvin, CG; Lahue, KG; Nolin, JD; Poynter, ME; Tully, JE | 1 |
Cardoso, WV; Chen, F; Cruikshank, WW; Fine, A; Kim, YK; Marquez, H; Qian, J; Quadro, L; Shao, F | 1 |
Brito, JM; Cabral, LD; de Brito Cervilha, DA; Garcia, ÉK; Moriya, HT; Santos, LM; Soncini, R; Teixeira, VP | 1 |
Aronsson, P; Carlsson, T; Tobin, G; Winder, M | 1 |
Johnson, AC; Lawrence, BP; Lojovich, SJ; O'Reilly, MA; Regal, JF | 1 |
Gu, W; Mao, S; Shi, Y; Tan, Y | 1 |
Beppu, A; Broide, DH; Doherty, TA; Hoffman, HM; McGeough, MD; Miller, M; Mueller, JL; Niwa, M; Pena, CA; Rosenthal, P; Suzukawa, M; Tam, AB | 1 |
Asano, T; Ishihara, T; Kobayashi, D; Kurotsu, S; Maruyama, T; Mizushima, T; Suzuki, H; Tanaka, K; Watanabe, H; Yamakawa, N; Yamashita, Y; Yamazaki, H | 1 |
Bergquist, M; Hanrieder, J; Hedenstierna, G; Hjoberg, J; Jonasson, S | 1 |
Chu, YH; Kao, CH; Liu, SC; Wang, HW; Wu, CC | 1 |
Awadalla, MA; Fischer, AJ; Hoegger, MJ; Hoffman, EA; McMenimen, JD; Michalski, AS; Moninger, TO; Ostedgaard, LS; Stoltz, DA; Tucker, AJ; Welsh, MJ; Zabner, J | 1 |
Allen, JS; Caruthers, SD; Eldridge, L; Jenkins, J; Keupp, J; Lanza, GM; Mitzner, W; Moldobaeva, A; Schmieder, A; Wagner, EM; Wickline, SA; Yang, X; Zhang, H; Zhang, Q | 1 |
Arikan-Ayyildiz, Z; Bagriyanik, A; Firinci, F; Karaman, M; Karaman, O; Kiray, M; Uzuner, N; Yilmaz, O | 1 |
Armani, MH; Barone, CA; Barthold, JS; Boyce, R; Kreiger, PA; Michelini, KA; Rodriguez, E; Shaffer, TH; Waldman, SA; Wang, J; Wolfson, MR; Zhu, Y | 1 |
Chen, PJ; Ko, JL; Lee, YT; Lue, KH; Wu, CT | 1 |
Armani, MH; Hobson, GM; Kreiger, PA; Rodriguez, E; Sakowski, L; Shaffer, TH; Waldman, SA; Zhu, Y | 1 |
Chow, CW; Evans, GJ; Godri Pollitt, K; Khanna, N; Scott, JA; Wang, X; Wu, J | 1 |
Fereydoonzad, L; Robichaud, A; Schuessler, TF | 1 |
Boskabady, MH; Gholami Mahtaj, L; Mohamadian Roshan, N | 1 |
Aronsson, P; Bergquist, F; Carlsson, T; Mitra, R; Tobin, G; Winder, M | 1 |
Dodam, JR; Graham, A; Grobman, M; Outi, H; Reinero, CR | 1 |
Al-Salam, S; Ali, BH; Beegam, S; Nemmar, A; Yuvaraju, P | 1 |
Chan, TK; Cheng, C; Fong, CW; Ho, WE; Lim, AY; Ong, CN; Peh, HY; Seng, KY; Seow, AC; Wong, WS | 1 |
Essilfie, AT; Hansbro, PM; Harding, R; Horvat, JC; O'Reilly, M; Sozo, F | 1 |
Benedetti, A; Fereydoonzad, L; Martin, JG; McGovern, TK; Novali, M; Robichaud, A; Schuessler, TF; Shalaby, KH | 1 |
Bates, G; Benedetti, A; Ijpma, G; Kachmar, L; Lauzon, AM; Lavoie, JP; Matusovsky, OS; Zitouni, N | 1 |
Britt, RD; Faksh, A; Kuipers, I; Martin, RJ; Pabelick, CM; Prakash, YS; Sieck, GC; Thompson, MA; Vogel, ER | 1 |
Elverdin, JC; Fernández-Solari, J; Martinel Lamas, DJ; Medina, VA; Mohn, C; Perazzo, JC; Prestifilippo, JP; Rios, CE; Rivera, ES | 1 |
Aliyeva, MI; Ather, JL; Bates, JH; Chung, M; Daphtary, NA; Dixon, AE; Forgione, PM; Georgsdottir, A; Hoyt, LR; Irvin, CG; Poynter, ME; Randall, MJ; Russell, SR; Suratt, BT | 1 |
Dennery, PA; Ito, M; Namba, F; Ogawa, R; Tamura, M; Watanabe, T | 1 |
Bongianni, F; Cinelli, E; Iovino, L; Mutolo, D; Pantaleo, T | 1 |
Kelada, SN | 1 |
Bartsch, JW; Chen, J; Deng, L; Dreymüller, D; Duan, Y; Jiang, X; Koller, G; Lin, F; Long, J; Luo, M; Mao, L; Müller, B; Wang, Y | 1 |
Li, C; Luo, Z; Lv, S; Ming, M; Sun, Q | 1 |
Guo, H; Hao, Y; Hui, Y; Ren, F; Wang, X; Zhao, L | 1 |
August, A; Bonneau, RH; Bourne, RA; Caruso, MJ; Caulfield, JI; Cavigelli, SA; Chirichella, NR; Craig, T; Klein, LC; Michael, KC | 1 |
Bae, BR; Chang, YS; Cho, SH; Choi, SJ; Kang, HR; Kang, SY; Lee, HS; Lee, JW; Min, KU; Oh, WI; Park, DE; Park, HW; Sohn, KH; Song, WJ | 1 |
Castrop, H; Kunzelmann, K; Schreiber, R | 1 |
Bozanich, EM; Gualano, RC; Hantos, Z; Larcombe, AN; Sly, PD; Turner, DJ; Zosky, GR | 1 |
Campbell, H; Karmouty-Quintana, H; Martin, JG; McGovern, T; Ramos-Barbón, D; Tuck, SA | 1 |
Shore, SA; Williams, ES; Zhu, M | 1 |
Jancar, S; Landgraf, RG | 1 |
Belmonte, KE; Berlanga, M; Budzik, B; Burman, M; Foley, JJ; Jin, J; Lainé, DI; Moore, ML; Morrow, DM; Palovich, M; Rivero, RA; Salmon, M; Sarau, HM; Shi, D; Wan, Z; Wang, F; Wang, Y; Webb, EF; Xie, H; Zhu, C | 1 |
Freyschmidt, EJ; Mathias, CB; Oettgen, HC | 1 |
Hedenstierna, G; Hedenström, H; Hjoberg, J; Jonasson, S | 1 |
Bullens, D; El Bakkoury, M; Garcia, L; Jacquet, A; Marchand, C; Mattéotti, C; Vandenbranden, M; Walgraffe, D | 1 |
Bond, RA; Dickey, BF; Hanania, NA; Knoll, BJ; Lin, R; Nguyen, LP; Omoluabi, O; Parra, S; Tuvim, MJ | 1 |
Beume, R; Braun, A; Hoymann, HG; Korolewitz, R; Krug, N; Muller, M; Wollin, L | 1 |
Gombos, RB; Hemmings, DG; McDonald, K; Wolan, V | 1 |
Acciani, TH; Deutsch, GH; Hardie, WD; Khurana Hershey, GK; Korfhagen, TR; Kramer, EL; Le Cras, TD; Mushaben, EM; Pastura, PA; Whitsett, JA | 1 |
Chen, BT; Driehuys, B; Foster, WM; Potts, EN; Slipetz, DM; Thomas, AC | 1 |
Chaudhary, D; Deng, B; Goldman, S; Ho, MW; Kasaian, M; Krane, CM; Mason, L; McDonald, CA; Mutyam, V; Pazdziorko, S; Williams, C | 1 |
de Mora, F; Herrerias, A; Marco, A; Picado, C; Roca-Ferrer, J; Serra, M; Torres, R | 1 |
De Vooght, V; Hoet, PH; Nemery, B; Synhaeve, N; Vanoirbeek, JA | 1 |
Bai, Y; Sanderson, MJ | 1 |
Ki, SH; Kim, SG; Kim, YM; Lee, CH; Lee, SJ; Lee, WH | 1 |
De Vooght, V; Haenen, S; Hoet, PH; Nemery, B; Vanoirbeek, JA; Verbeken, E | 2 |
Burchell, JT; Holt, PG; Larcombe, AN; Sly, PD; Stumbles, PA; Turner, DJ; von Garnier, C; White, OJ; Wikstrom, ME; Zosky, GR | 1 |
Bayat, S; Habre, W; Hantos, Z; Janosi, TZ; Petak, F; Porra, L; Sovijärvi, AR; Strengell, S; Suhonen, H; Suortti, P | 1 |
Cataldo, DD; Crahay, C; Foidart, JM; Gueders, MM; Hacha, J; Louis, R; Noël, A; Paulissen, G; Quesada-Calvo, F; Tournoy, K; Van Hove, C | 1 |
Ishii, H; Kondo, T; Kondo, Y; Tanigaki, T; Tazaki, G; Tsuji, C | 1 |
Inoue, K; Ishii, T; Koike, E; Takano, H; Warabi, E; Yanagawa, T; Yanagisawa, R | 1 |
Hassan, M; Labonté, I; Lauzon, AM; Laviolette, M; Martin, JG; Risse, PA; Tsuchiya, K | 1 |
Adori, C; Komlósi, ZI; Kovács, L; Kozma, GT; Losonczy, G; Pállinger, E; Rusai, K; Szabó, A; Szebeni, B; Sziksz, E; Vannay, A | 1 |
Bánfi, A; Baráti, L; Bari, F; Novák, Z; Peták, F; Székely, E; Tóth-Szüki, V | 1 |
Bullens, DM; Cadot, P; Ceuppens, JL; Meyts, I; Vanaudenaerde, B; Vanoirbeek, JA | 1 |
Beghetti, M; Fontao, F; Habre, W; Janosi, TZ; Pache, JC; Peták, F; Regli, A; von Ungern-Sternberg, BS | 1 |
Cruz, MJ; De Vooght, V; Haenen, S; Hoet, PH; Morell, F; Muñoz, X; Nemery, B; Vanoirbeek, JA; Wijnhoven, K | 1 |
Bassett, D; Doyon-Reale, N; Gao, X; Hirata, F; Kannan, R; Kerr, J; Lieh-Lai, M; Wilson, S | 1 |
Gelfand, EW; Larsen, ST; Matsubara, S; McConville, G; Poulsen, SS | 1 |
Blacquière, MJ; Geerlings, M; Hylkema, MN; Melgert, BN; Postma, DS; Timens, W | 1 |
Bissonnette, EY; Careau, E; Lauzon-Joset, JF; Turmel, V | 1 |
Asano, T; Hasegawa, Y; Ito, S; Kume, H; Taki, F | 1 |
Hedenstierna, G; Hjoberg, J; Jonasson, S | 1 |
Gold, LG; Martin, JG; Robichaud, A; Schuessler, TF; Shalaby, KH | 1 |
Cleave, J; Gordon, JR; Town, J; Willson, PJ | 1 |
Chung, YJ; Copeland, LB; Doerfler, DL; Ward, MD | 1 |
Choi, JP; Choi, SJ; Elias, JA; Gho, YS; Jeon, SG; Kim, YK; Kim, YS; Lee, BJ; Lee, CG; Oh, S-; Zhu, Z | 1 |
Ab'Saber, AM; Abreu, SC; Antunes, MA; Capelozzi, VL; Ferreira, TP; Martins, MA; Parra-Cuentas, ER; Rocco, PR; Silva, AL; Silva, PM | 1 |
Foong, RE; Larcombe, AN; Sly, PD; Zosky, GR | 1 |
Inoue, K; Koike, E; Takano, H | 1 |
Clynen, E; De Vooght, V; Haenen, S; Hoet, PH; Maes, E; Nemery, B; Schoofs, L; Vanoirbeek, JA | 1 |
Chin, K; Sakai, R; Torii, K; Yoneda, J | 1 |
Ellis, R; Inman, MD; Labiris, NR; Turi, GJ; Wattie, JN | 1 |
Amer, M; Chiarenza, AP; Elverdin, JC; Fernández-Solari, J; Medina, VA; Vacas, MI | 1 |
Bauer, A; Gleason, AM; Golden, G; Kielian, T; Oldenburg, P; Poole, JA; Romberger, DJ; Sisson, JH; West, WW; Wyatt, TA | 1 |
Chu, X; Ci, X; Deng, X; Hua, S; Wei, D; Wei, M | 1 |
Borate, B; Brass, DM; Carpenter, DE; Collins, FS; Cook, DN; Evans, CM; Kelada, SN; Kubalanza, K; Maruoka, S; Olive, M; Roy, MG; Schwartz, DA; Tavarez, U; Whitehead, GS; Wilson, MS; Wynn, TA | 1 |
Basu, S; Fan, Y; Halayko, AJ; Kadkhoda, K; Qiu, H; Wang, S; Yang, X | 1 |
El-Osta, A; Karagiannis, TC; Li, X; Orlowski, C; Royce, SG; Tang, ML; Tang, MM | 1 |
Fehrenbach, H; Garn, H; Kerzel, S; Maier, RF; Preisser, K; Rogosch, T; Schroeder, HW; Wagner, J; Yildirim, AÖ; Zemlin, M | 1 |
Ellis, R; Feng, M; Inman, MD; Lu, WY; Wang, S; Wattie, J; Xiang, YY | 1 |
Butte, AJ; Eckart, MR; Galli, SJ; Morgan, AA; Mukai, K; Tsai, M; Yu, M | 1 |
Foster, MW; Michael Foster, W; Potts, EN; Que, LG; Yang, Z | 1 |
Ahn, KS; Jang, HY; Jeong, H; Kim, SM; Kwon, OK; Lee, HK; Oh, SR; Yuk, JE | 1 |
Bloksma, N; Maazi, H; Nawijn, MC; Shirinbak, S; van Oosterhout, AJ | 1 |
Debaun, MR; Feroah, TR; Hillery, CA; Holzhauer, SL; Hutchins, W; Nandedkar, SD; Pritchard, KA; Schulte, ML; Strunk, RC | 1 |
Barrett, EG; Day, KC; Gigliotti, AP; Mauderly, JL; McDonald, JD; Reed, MD; Seilkop, SK | 1 |
Bellusci, S; Belperio, J; Corral, J; Karadag, A; Li, Y; Rehan, VK; Sakurai, R; Torday, JS; Xue, YY | 1 |
Carter, L; Gelfand, EW; Hicken, E; Jackson, L; Jia, Y; Robinson, J; Shin, YS; Shiraishi, Y; Takeda, K; Wang, M; Wright, AD | 1 |
Batt, J; Correa, J; Khanna, N; North, ML; Plant, PJ; Scott, JA; Ward, A; Ward, M | 1 |
Barcham, G; Barker, D; Koumoundouros, E; Snibson, K; Van der Velden, J | 1 |
Driehuys, B; Foster, WM; Kaushik, SS; Nouls, J; Potts, EN; Slipetz, DM; Thomas, AC | 1 |
Cheng, C; Goh, FY; Guan, S; Leung, BP; Sethi, G; Shanmugam, MK; Upton, N; Wong, WS | 1 |
Borthwell, RM; Finkbeiner, WE; Hajighasemi-Ossareh, M; Lachowicz-Scroggins, ME; Modlin, S; Stevens, JE; Widdicombe, JH | 1 |
Aliyeva, M; Bates, JH; Lundblad, LK; Stevenson, CA | 1 |
Atabai, K; Bernstein, X; Chen, C; Engler, MB; Huang, KE; Huang, X; Kudo, M; Li, JT; Melton, AC; Ren, X; Sheppard, D; Wang, Y | 1 |
Cheon, HG; Kwak, HJ; Nam, JY; No, Z; Song, JS; Yang, SD | 1 |
Broadley, KJ; Ferrari, N; Ford, WR; Kidd, EJ; Nevin, B; Paquet, L; Renzi, P; Turner, Dl | 1 |
Bucht, A; Jonasson, S; Koch, B; Wigenstam, E | 1 |
Bauer, C; Gleason, AM; Oldenburg, PJ; Poole, JA; Romberger, DJ; Sisson, JH; West, WW; Wyatt, TA | 1 |
Aravamudan, B; Meuchel, LW; Pabelick, CM; Prakash, YS; Sieck, GC; Thompson, M; VanOosten, SK; Vohra, P | 1 |
Amatullah, H; Chow, CW; Cooper, J; Godri, K; Khanna, N; North, ML; Penton, PC; Scott, JA; Wang, X | 1 |
Chang, HY; Mitzner, W; Watson, J | 1 |
Ko, JL; Ku, MS; Lee, SS; Lee, YT; Lu, KH; Lue, KH; Sheu, JN; Sun, HL | 1 |
Dong, J; Duan, X; Jin, H; Li, B; Luo, Q; Lv, Y; Nurahmat, M; Wang, G; Wu, J; Zheng, Y | 1 |
Albu, G; Beghetti, M; Habre, W; Lele, E; Petak, F | 1 |
Howell, MD; Jean Meade, B; Weissman, DN | 1 |
Dey, RD; Fedan, JS; Satterfield, BE; Wu, ZX | 1 |
Aoki-Nagase, T; Kurihara, H; Kurihara, Y; Nagai, R; Nagase, T; Oh-Hashi, Y; Ohga, E; Ouchi, Y; Shindo, T; Tomita, T; Yamaguchi, Y; Yamamoto, H | 1 |
Benser, ME; Ideker, RE; Smith, WM; Walcott, GP; Zheng, X | 1 |
Bay, BH; Chua, KY; Duan, W; Kuo, IC; Selvarajan, S; Wong, WS | 1 |
Hattori, T; Ichinose, M; Ishigaki-Suzuki, S; Koarai, A; Kuramasu, A; Makabe-Kobayashi, Y; Ohtsu, H; Sakurai, E; Shirato, K; Sugiura, H; Watanabe, T; Yamagata, S | 1 |
Clerbaux, T; De Kock, M; Detry, B; Gianello, P; Jolliet, P; Liistro, G; Reynaert, M; Roeseler, J; Veriter, C; Watremez, C | 1 |
Chi, EY; Harlan, JM; Henderson, WR; Iwata, A; Nishio, K; Winn, RK | 1 |
Işlekel, H; Karaman, O; Kargi, A; Kavukçu, S; Ozkal, S; Soylu, A; Uzuner, N; Yilmaz, O | 1 |
Campbell, HR; Eidelman, DH; Gautrin, D; Hamid, Q; Iijima, H; Maghni, K; Malo, JL; Martin, JG | 1 |
Clerbaux, T; deKock, M; Detry, B; Gianello, P; Jolliet, P; Liistro, G; Reynaert, M; Roeseler, J; Watremez, C | 1 |
Folkerts, G; Hoekstra, MO; Nijkamp, FP; Schijf, MA; Smit, JJ; Van Loveren, H | 1 |
Amemiya, T; Fujimura, M; Ishiura, Y; Kurashima, K; Myou, S; Nobata, K; Nonomura, A | 1 |
Cui, ZH; Gelfand, EW; Joetham, A; Kanehiro, A; Takeda, K | 1 |
Broide, DH; Cho, JY; Ikeda, RK; McElwain, K; McElwain, S; Miller, M; Nayar, J; Raz, E; Walker, L | 1 |
Aronica, MA; Boothby, M; Goral, M; McCarthy, S; Mitchell, D; Sheller, JR; Swaidani, S | 1 |
Collins, RA; Herbert, C; Kumar, RK; Sly, PD; Turner, DJ | 1 |
Archer, AJ; Colasurdo, G; Cramton, JL; Holian, A; Pfau, JC | 1 |
Cannet, C; Ellis, KM; Fozard, JR; Mazzoni, L | 1 |
Harada, T; Mori, M; Tomioka, S; Tsukagoshi, H; Yoshimi, S | 1 |
Bissonnette, EY; Careau, E | 1 |
Foster, WM; Liao, G; Peltz, G; Savov, JD; Schwartz, DA; Usuka, J; Wang, J; Whitehead, GS | 1 |
Abraha, D; Agrawal, DK; Cho, SH; Oh, CK; Park, JM | 1 |
Aydintug, MK; Born, WK; Gelfand, EW; Hahn, YS; Kanehiro, A; Lahn, M; O'Brien, RL; Wands, JM | 1 |
Boskabady, MH; Zarei, A | 1 |
Ceuppens, JL; Hoet, PH; Nemery, B; Tarkowski, M; Vanoirbeek, JA; Verbeken, EK | 1 |
Morimoto, K; Mukaiyama, O; Nosaka, E; Takahashi, S; Yamashita, M | 2 |
Dakhama, A; Gelfand, EW; Kodama, T; Miyahara, N; Miyahara, S; Ott, VL; Swanson, BJ; Takeda, K; Taube, C | 1 |
Askenase, PW; Campos, RA; Fukui, M; Geba, GP; Homer, RJ; Iliopoulou, BP; Itakura, A; Kawikova, I; Paliwal, V; Pober, JS; Szczepanik, M; Tsuji, RF | 1 |
Holt, PG; Sly, PD; Stumbles, PA; Turner, DJ; von Garnier, C; Zosky, GR | 1 |
Das, M; Gangal, SV; Ghosh, B; Ram, A | 1 |
Flynt, L; Imrich, A; Johnston, RA; Mellema, MS; Schwartzman, IN; Shore, SA | 1 |
Fujimura, M; Nakao, S; Nishitsuji, M; Oribe, Y | 1 |
Chai, OH; Hwang, PH; Kim, JS; Lee, KS; Lee, MK; Lee, YC; Park, SJ; Song, CH; Yi, HK | 1 |
Huang, J; Ideker, RE; Smith, WM; Walcott, GP; Zheng, X | 1 |
Aburada, M; Kase, Y; Maruyama, H; Sasaki, T; Takeda, S | 1 |
Arantes-Costa, FM; Kasahara, DI; Lopes, FD; Martins, MA; Nunes, MP; Perini, A | 1 |
Adachi, M; Akabane, T; Asano, K; Honma, I; Ieki, K; Iwase, M; Kawaguchi, M; Kokubu, F; Kurokawa, M; Matsukura, S; Odaka, M; Suzuki, S; Takeuchi, H; Watanabe, S | 1 |
McCusker, CT; Wang, Y | 1 |
Choi, IW; Im, SY; Kim, JH; Kim, YS; Ko, HM; Lee, HK; Lee, JH; Lee, YC; Park, YM; You, HJ | 1 |
Bates, JH; Irvin, CG; Norton, RJ; Rinaldi, LM; Wagers, SS | 1 |
Bonacci, JV; Fernandes, DJ; Quan, L; Stewart, AG; Taylor, CC; Ward, JE | 1 |
Blaydon, C; Bonneau, O; Ferretti, S; Stevenson, CS; Trifilieff, A; Wyss, D | 1 |
Birolini, D; de Arruda, MJ; Fontes, B; Poggetti, RS; Souza, AL; Younes, RN | 1 |
Boothby, M; Davies, SS; Dworski, R; Mernaugh, R; Meyrick, B; Mitchell, D; Peebles, RS; Roberts, LJ; Sheller, JR; Talati, M | 1 |
Atkins, C; Colasurdo, GN; Elidemir, O; Fullmer, JJ; Khan, AM; Stark, JM | 1 |
Bissonnette, EY; Careau, E; Pouliot, P; Proulx, LI; Spahr, A; Turmel, V | 1 |
Lomask, M | 1 |
Ahn, K; Joung, H; Kim, DY; Kim, JH; Kwon, OK; Lee, HK; Lee, J; Lee, MY; Lee, S; Oh, SR; Park, BY | 1 |
Arata, S; Gabazza, EC; Homma, I; Iwase, M; Kimura, H; Miyamoto, K; Nyui, M; Sakai, Y | 1 |
Galli, SJ; Jones, C; Tam, SY; Tsai, M; Yu, M; Zehnder, J | 1 |
Deng, JF; Deng, YM; Ke, CK; Shao, CS; Xie, QM; Zhang, H | 1 |
Azoulay, E; Gil, FR; Lauzon, AM; Maghni, K; Zitouni, NB | 1 |
Ketonen, J; Leinonen, M; Paakkari, I; Saikku, P; Törmäkangas, L | 1 |
Guedes, AG; Kannan, MS; Kita, H; Lund, FE; Paulin, J; Rivero-Nava, L | 1 |
Adler, KB; Agrawal, A; Dickey, BF; Fahim, M; Ghosh, B; Ram, A; Rengarajan, S | 1 |
Chen, JQ; Deng, JF; Deng, YM; Sun, JG; Tang, HF; Xie, QM; Yang, SY | 1 |
Ceuppens, J; De Vooght, V; Hoet, PH; Mercier, CM; Nemery, B; Tarkowski, M; Vanhooren, HM; Vanoirbeek, JA | 1 |
Bates, JH; Haverkamp, HC; Irvin, CG; Norton, RJ; Sullivan, MJ; Thompson-Figueroa, JA; Wagers, SS | 1 |
Clarke, ZL; Lang, D; Lewis, MJ; Miller, AL; Moat, SJ; Randall, MD | 1 |
Demant, P; Groot, PC; Hofman, GA; Jeurink, PV; Piavaux, B; Van Oosterhout, AJ | 1 |
Bienenstock, J; Forsythe, P; Inman, MD | 1 |
Ansari, HR; Fan, M; Jamal Mustafa, S; Ledent, C; Nadeem, A | 1 |
Nickell, LE; Snyder, DW; Stengel, PW; Wolos, JA | 1 |
Bozanich, EM; Collins, RA; Hantos, Z; Jánosi, TZ; Sly, PD; Thamrin, C; Turner, DJ | 1 |
Alenius, H; Haapakoski, R; Husgafvel-Pursiainen, K; Lehto, M; Leino, M; Määttä, J; Savolainen, K; Tillander, S; Wolff, H | 1 |
Bonneau, O; Trifilieff, A; Wyss, D | 1 |
de Groot, AA; Mathy, MJ; Peters, SL; van Zwieten, PA | 1 |
Finlay-Jones, JJ; Gorman, S; Hart, PH; Larcombe, AN; McGlade, JP; Sly, PD; Turner, DJ; Zosky, GR | 1 |
Bergren, DR | 1 |
Guo, WK; Snyder, DW; Stengel, PW; Wolos, JA; Zeckner, DJ | 1 |
Chew, AD; Ellis, R; Hirota, JA; Inman, MD; Janssen, LJ; Wattie, J | 1 |
Bozza, M; Cagido, VR; Capelozzi, VL; Dolhnikoff, M; Morales, MM; Negri, EM; Passaro, CP; Rocco, PR; Silva, PL; Zin, WA | 1 |
Balhorn, A; Dakhama, A; Gelfand, EW; Joetham, A; Loader, JE; Matsubara, S; Miyahara, N; Ohnishi, H; Swasey, CH; Takeda, K | 1 |
Armstrong, SR; Briones, S; Hegde, SS; Horger, B; Jaw-Tsai, S; Richardson, CL | 1 |
Burchell, JT; Hantos, Z; Holt, PG; Janosi, TZ; Larcombe, AN; Sly, PD; Turner, DJ; White, OJ; Zosky, GR | 1 |
In, M; Iwashita, K; Kawasaki, H; Kuwabara, T; Mataki, Y; Sawada, M | 1 |
Ahn, MH; Jang, AS; Kwon, JH; Lee, SH; Lee, YM; Park, CS; Rhim, TY; Song, HM; Takizawa, H | 1 |
Carpenter, GH; Correia, PN; Osailan, SM; Paterson, KL; Proctor, GB | 1 |
Andersson, MC; Giglio, D; Tobin, G | 1 |
Johnston, RA; Lu, FL; Shore, SA; Terry, RD; Theman, TA; Williams, ES | 1 |
Broadley, KJ; Fernandez-Rodriguez, S; Ford, WR; Kidd, EJ | 1 |
Bates, JH; Cojocaru, A; Haverkamp, HC; Irvin, CG | 1 |
Gelfand, EW; Goya, S; Hamelmann, E; Pichavant, M; Umetsu, DT | 1 |
Ghosh, B; Mabalirajan, U; Ram, A; Singh, SK; Singh, VP | 1 |
Burton, MD; McKenzie, R; Royce, SG; Tang, ML | 1 |
Downes, H; Hirshman, CA; Leon, DA; Peters, JE | 1 |
Harada, N; Hata, T; Itoh, E; Kita, T | 1 |
Knippenberg, RW; Kudlacz, EM | 1 |
Fujimura, M; Matsuda, T; Mizuhashi, K; Saito, M; Songür, N; Xiu, QY | 1 |
Baur, X; Hoffarth, HP; Marek, W; Potthast, J; Ulmer, WT | 1 |
Folkerts, G; Nijkamp, FP; Omini, C; van der Linde, HJ | 1 |
Fukata, Y; Fukushima, H; Harada, K; Kaneta, S; Miwa, A; Ogawa, N | 1 |
Buikema, H; de Smet, BJ; Lie, KI; Scholtens, E; van Gilst, WH; van Veldhuisen, DJ; Wesseling, H | 1 |
Black, C; Curry, C; Emala, C; Hirshman, CA; Levine, MA | 1 |
Isono, T; Kohsaka, M; Koibuchi, Y; Mori, J; Ohtsuka, M; Ozaki, R; Sakai, S; Sato, N; Yamamoto, T | 1 |
Itoh, K; Mukaiyama, O; Satoh, Y; Takahashi, E; Yamaguchi, T | 2 |
Foster, PS; Hogan, SP; Matthaei, KI; Ramsay, AJ; Young, IG | 1 |
Marek, W; Ulmer, WT | 1 |
Bateman, RD; Beadle, RE; Guthrie, AJ; White, CE | 1 |
Andresen, CJ; Smith, WB; Turner, CR; Watson, JW | 1 |
Albert, RK; Chi, EY; Chiang, GK; Eriksen, P; Henderson, WR; Jonas, M; Jones, F; Lamm, WJ; Lewis, DB; Tien, YT; Zhang, Y | 1 |
Cernadas, M; Christiani, DC; De Sanctis, GT; Donovan, C; Finn, PW; Katona, I; Kobzik, L; Krinzman, SJ; Listman, J; Mark, D; Nassr, K; Perkins, DL; Wang, Y | 1 |
Elias, JA; Flavell, RA; Geba, GP; Homer, RJ; Kuhn, C; Ray, P; Tang, W; Zheng, T | 1 |
Hessel, EM; Hofman, G; Nijkamp, FP; Savelkoul, HF; Van Ark, I; Van Esch, B; Van Loveren, H; Van Oosterhout, AJ | 1 |
Gowski, DT; Hoffman, LA; Lutz, J; Miro, AM; Pinsky, MR; Sigler, DW; Tasota, FJ; Zullo, T | 1 |
Long, NC; Martin, JG; Pantano, R; Shore, SA | 1 |
Chan, B; Hofstra, CL; Jardieu, PM; Nijkamp, FP; Shields, R; Van Ark, I; Van Oosterhout, AJ | 1 |
Gelfand, EW; Hamelmann, E; Irvin, CG; Larsen, GL; Oshiba, A; Schwarze, J; Takeda, K | 1 |
Albert, RK; Chi, EY; Christie, PE; Chu, SJ; Harlan, JM; Henderson, WR; Jonas, M; Lamm, WJ; Rochon, Y | 1 |
Enhorning, G; van Schaik, SM; Vargas, I; Welliver, RC | 1 |
Sly, PD; Uhlig, T; Wildhaber, JH | 1 |
Bluestone, JA; Cattamanchi, A; Elliott, D; Herrmann, K; Li, X; Mathur, M; Padrid, PA; Qin, Y; Sperling, AI; Weinstock, J | 1 |
Bhan, AK; Brewer, JP; Geha, RS; Martin, TR; Mizoguchi, E; Spergel, JM | 1 |
Hall, GL; Peták, F; Sly, PD | 1 |
Hofman, G; Hofstra, CL; Kapsenberg, ML; Nijkamp, FP; Savelkoul, HF; Van Ark, I; Van Esch, B; Van Oosterhout, AJ; Weller, FR | 1 |
Ishikawa, T; Nishino, T; Sato, J; Shinozuka, N | 1 |
Hofman, G; Hofstra, CL; Jardieu, PM; Nijkamp, FP; Van Ark, I; Van Oosterhout, AJ | 1 |
De Sanctis, GT; Donovan, CE; Finn, PW; Kobzik, L; Krinzman, SJ; Lederer, J; Linsley, PS; Mark, DA; Perkins, DL; Sayegh, MH | 1 |
De Boer, J; Meurs, H; Pouw, FM; Zaagsma, J | 1 |
Broide, D; Gelfand, EW; Gifford, T; Malek, S; Martin-Orozco, E; Nguyen, MD; Raz, E; Schwarze, J; Tighe, H; Van Uden, J | 1 |
Berry, G; DeKruyff, RH; Hansen, G; Umetsu, DT | 1 |
Dawson, CA; Kelly, KJ; Krenz, GS; Kurup, VP; Rickaby, DA; Thakker, JC; Xia, JQ | 1 |
Agrawal, DK; Chong, BT; Romero, FA; Townley, RG | 1 |
Foster, PS; Hogan, SP; Kumar, RK; Shepherd, DP; Temelkovski, J | 1 |
De Sanctis, GT; Drazen, JM; Fabian, AJ; Grasemann, H; Hamada, K; Huang, PL; Jiao, A; Kobzik, L; MacLean, JA; Mehta, S; Scott, JA; Venugopal, CS; Wolyniec, WW; Yandava, CN | 1 |
Bice, DE; Collie, DD; Lipscomb, MF; Lyons, CR; Wilder, JA; Wilson, BS | 1 |
Baradaran-Hosseini, E; Puddington, L; Schramm, CM; Stengel, P; Thrall, RS; Whiteley, HE; Wolyniec, WW; Yiamouyiannis, CA | 1 |
Cooper, RA; Fotuhi, PC; Ideker, RE; Rollins, DL; Smith, WM; Sreenan, CM | 1 |
Denburg, JA; Ellis, R; Inman, MD; O'Byrne, PM; Wattie, J | 1 |
Angell, T; Bonnefoy, JY; Chvatchko, Y; Dasic, G; Graber, P; Herren, S; Juillard, P; Knowles, R; Kosco-Vilbois, MH | 1 |
Ross, DL; Thomas, SP | 1 |
Amemiya, T; Fujimura, M; Ishiura, Y; Liu, Q; Matsuda, T; Myou, S; Nobata, K; Tachibana, H | 1 |
Chi, EY; Henderson, WR; Maliszewski, CR | 1 |
Kohno, S; Mizutani, N; Nabe, T; Sasaki, K; Takenaka, H | 1 |
Alarie, Y; Braun, A; Daser, A; Glaab, T; Herz, U; Kips, J; Lommatzsch, M; Neuhaus-Steinmetz, U; Renz, H | 1 |
Hamada, H; Hiwada, K; Kohno, N; Sakai, K; Yokoyama, A; Zhao, GD | 1 |
Chi, EY; Dietsch, GN; Henderson, WR; Lu, J; Poole, KM | 1 |
Holt, PG; Sly, PD; Tulić, MK; Wale, JL | 1 |
Galli, SJ; Williams, CM | 1 |
Bochnowicz, S; Hart, T; Hay, DW; Louden, C; Luttmann, MA; Osborn, RR; Underwood, DC | 1 |
Collins, RD; Graham, BS; Jarzecka, K; Mitchell, DB; Peebles, RS; Sheller, JR | 1 |
Fujiwara, Y; Gerard, C; Gerard, NP; Humbles, AA; Israel, E; Lilly, C; Lu, B; Nilsson, CA | 1 |
Bouchard, P; Holbert, D; Sur, S; Van Scott, MR | 1 |
Bertrand, C; El-Hashim, A; Trifilieff, A | 1 |
George, CL; Jin, H; Kline, JN; O'Neill, ME; O'Shaughnessy, P; Phipps, JC; Schwartz, DA; Thorne, PS; Wohlford-Lenane, CL | 1 |
Broide, DH; Castaneda, D; Nayar, J; Sriramarao, P; Stachnick, G | 1 |
Feldman, S; Fu, SM; Kim, Y; Kuziel, WA; Rose, CE | 1 |
Han, SH; Peng, HJ; Su, YC; Tsai, JJ; Wang, SR | 1 |
Chu, HW; Harbeck, RJ; Honour, JM; Martin, RJ | 1 |
Fiscus, LC; Steeber, DA; Tang, ML; Tedder, TF; Van Herpen, J | 1 |
Buescher, H; Fozard, JR | 1 |
Doerschuk, CM; Le Blanc, B; Murthy, GG; Schwartzman, IN; Shore, SA | 1 |
Deurloo, DT; Hofstra, CL; Nijkamp, FP; van Esch, BC; van Oosterhout, AJ | 1 |
Chiang, BL; Hong, RL; Ku, PH; Lai, YL; Lee, YL; Wu, YL; Ye, YL; Yu, CI | 1 |
Ishii, S; Nagase, T; Ouchi, Y; Shimizu, T; Shindou, H | 1 |
Blease, K; Hogaboam, CM; Schuh, JM | 1 |
Foster, PS; Herbert, C; Kumar, RK; Yang, M | 1 |
Bates, JH; Irvin, CG; Lundblad, L; Moriya, HT; Wagers, S | 1 |
Go, K; Hata, T; Namimatsu, A; Okazaki, R | 1 |
Aghili, S; Garland, A; Glagov, S; Hernandez, C; Hershenson, MB; Punjabi, N; Ray, DW; Solway, J | 1 |
Adachi, M; Hoshino, H; Kobayashi, H; Kokubu, F; Konno, S; Minoguchi, K; Mita, S; Okazawa, A; Sunouchi, K; Takahashi, T | 1 |
Go, K; Hata, T; Namimatsu, A | 1 |
Castleman, WL; Lemanske, RF; McAllister, PK; Sorkness, RL | 1 |
Austin, DR; Hanifin, JM; Hirshman, CA; Hulbert, W; Klein, W | 1 |
Austin, DR; Downes, H; Hirshman, CA; Parks, CM | 1 |
Frick, OL; Gold, WM; Hartiala, J; Mapp, C; Shields, RL | 1 |
1 review(s) available for methacholine chloride and Disease Models, Animal
Article | Year |
---|---|
Further exploration of the Penh parameter.
Topics: Airway Resistance; Allergens; Animals; Bronchoconstriction; Disease Models, Animal; Methacholine Chloride; Mice; Physical Conditioning, Animal; Plethysmography, Whole Body; Respiratory Mechanics | 2006 |
2 trial(s) available for methacholine chloride and Disease Models, Animal
Article | Year |
---|---|
A probative approach for noninvasive evaluation of airway hyperresponsiveness and remodeling in adult asthmatics.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Airway Resistance; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Disease Models, Animal; Female; Humans; Male; Methacholine Chloride; Middle Aged; Models, Biological; Muscle, Smooth; Outcome and Process Assessment, Health Care; Practice Guidelines as Topic; Respiratory Function Tests; Treatment Outcome | 2004 |
A role for the C3a anaphylatoxin receptor in the effector phase of asthma.
Topics: Animals; Antigens, CD; Asthma; Complement C3a; Disease Models, Animal; Female; Humans; Hypersensitivity, Immediate; Lung; Male; Membrane Proteins; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Plethysmography; Receptor, Anaphylatoxin C5a; Receptors, Complement | 2000 |
328 other study(ies) available for methacholine chloride and Disease Models, Animal
Article | Year |
---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Topics: Airway Remodeling; Animals; Anisakis; Antibody Specificity; Biomarkers; Bronchial Hyperreactivity; Cytokines; Disease Models, Animal; Inflammation Mediators; Lung; Methacholine Chloride; Mice, Inbred BALB C; Pneumonia; Th2 Cells | 2021 |
Therapeutic ketosis decreases methacholine hyperresponsiveness in mouse models of inherent obese asthma.
Topics: 3-Hydroxybutyric Acid; Animals; Asthma; Bronchial Hyperreactivity; Diet, High-Fat; Diet, Ketogenic; Disease Models, Animal; Esters; Gastrointestinal Microbiome; Ketone Bodies; Ketosis; Male; Methacholine Chloride; Mice, Inbred C57BL; Obesity; Weight Loss | 2022 |
Azithromycin inhibits mucin secretion, mucous metaplasia, airway inflammation, and airways hyperresponsiveness in mice exposed to house dust mite extract.
Topics: Adenosine Triphosphate; Allergens; Animals; Asthma; Azithromycin; Disease Models, Animal; Inflammation; Interleukin-13; Metaplasia; Methacholine Chloride; Mice; Mucins; Mucus; Pyroglyphidae | 2022 |
Measurement of Airway Hyperresponsiveness in Mice.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Eosinophilia; Immunoglobulin E; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiration Disorders; Respiratory Hypersensitivity | 2022 |
A retro-inverso modified peptide alleviated ovalbumin-induced asthma model by affecting glycerophospholipid and purine metabolism of immune cells.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Immunoglobulin E; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Ovalbumin; Purines | 2023 |
Tracheomalacia in bronchopulmonary dysplasia: Trachealis hyper-relaxant responses to S-nitrosoglutathione in a hyperoxic murine model.
Topics: Animals; Asthma; Bronchodilator Agents; Bronchopulmonary Dysplasia; Disease Models, Animal; Humans; Hyperoxia; Infant, Newborn; Methacholine Chloride; Mice; Muscle, Smooth; S-Nitrosoglutathione; Signal Transduction; Trachea; Tracheomalacia | 2019 |
Exposure to lipopolysaccharide (LPS) reduces contractile response of small airways from GSTCD-/- mice.
Topics: Animals; Bronchioles; Disease Models, Animal; Female; Gene Knockout Techniques; Glutathione Transferase; Lipopolysaccharides; Male; Methacholine Chloride; Mice; Muscle Contraction; Tumor Necrosis Factor-alpha; Up-Regulation | 2019 |
Beneficial Effects of Neurotensin in Murine Model of Hapten-Induced Asthma.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Gene Expression Regulation; Haptens; Humans; Injections, Intraperitoneal; Leukocytes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neurotensin; Pyrazoles; Quinolines | 2019 |
Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch.
Topics: Animals; Asthma; Bronchoconstrictor Agents; Cells, Cultured; Disease Models, Animal; Female; Glycolysis; Humans; Hydrogen; Lactic Acid; Leukocytes, Mononuclear; Lung; Male; Methacholine Chloride; Mice; Middle Aged; Ovalbumin; Oxidative Phosphorylation; Primary Cell Culture | 2020 |
Airway Hyperresponsiveness Is Severe and Persistent in an Equine Model of Neutrophilic Asthma.
Topics: Airway Remodeling; Animals; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Disease Models, Animal; Horse Diseases; Horses; Humans; Methacholine Chloride; Neutrophils; Respiratory Hypersensitivity; Species Specificity | 2020 |
Pulmonary delivery of ORMDL3 short hairpin RNA - a potential tool to regulate allergen-induced airway inflammation.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Inflammation; Lung; Male; Membrane Proteins; Methacholine Chloride; Mice; Mice, Knockout; Mice, Transgenic; Pulmonary Eosinophilia; Respiratory Hypersensitivity; RNA Interference; RNA, Small Interfering | 2020 |
The Effect of Bronchoconstriction by Methacholine Inhalation in a Murine Model of Asthma.
Topics: Administration, Inhalation; Allergens; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Eosinophils; Female; Humans; Lung; Macrophages; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Transforming Growth Factor beta | 2020 |
Anti-Inflammatory Effects of a
Topics: Animals; Anti-Inflammatory Agents; Asthma; beta-N-Acetylhexosaminidases; Body Weight; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Capsaicin; Cordyceps; Cytokines; Disease Models, Animal; Eosinophil Peroxidase; Female; Histamine Release; Immunization; Immunoglobulin E; Mast Cells; Methacholine Chloride; Mice, Inbred BALB C; Mycelium; Nasal Lavage; Ovalbumin; Rats, Sprague-Dawley; Rhinitis, Allergic; Skin; Spleen; Trachea | 2020 |
Antioxidant MnTBAP does not protect adult mice from neonatal hyperoxic lung injury.
Topics: Animals; Animals, Newborn; Antioxidants; Bronchoconstrictor Agents; Bronchopulmonary Dysplasia; Disease Models, Animal; Female; Hyperoxia; Male; Metalloporphyrins; Methacholine Chloride; Mice; Mice, Inbred C57BL; Plethysmography, Whole Body; Pregnancy | 2020 |
TMT-based quantitative proteomics reveals suppression of SLC3A2 and ATP1A3 expression contributes to the inhibitory role of acupuncture on airway inflammation in an OVA-induced mouse asthma model.
Topics: Acupuncture Therapy; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Fusion Regulatory Protein 1, Heavy Chain; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucus; Ovalbumin; Proteomics; Respiratory Hypersensitivity; Sodium-Potassium-Exchanging ATPase | 2021 |
Mast cell-derived serotonin enhances methacholine-induced airway hyperresponsiveness in house dust mite-induced experimental asthma.
Topics: Animals; Asthma; Disease Models, Animal; Humans; Lung; Mast Cells; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pyroglyphidae; Serotonin | 2021 |
Levosimendan prevents bronchoconstriction and adverse respiratory tissue mechanical changes in rabbits.
Topics: Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchoconstriction; Cardiac Output; Disease Models, Animal; Glyburide; Hydrazones; KATP Channels; Lung; Male; Methacholine Chloride; Pyridazines; Rabbits; Simendan | 2017 |
Lung responses in murine models of experimental asthma: Value of house dust mite over ovalbumin sensitization.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Lung; Methacholine Chloride; Mice, Inbred BALB C; Muscle, Smooth; Ovalbumin; Pneumonia; Pyroglyphidae; Respiratory Mechanics | 2018 |
Effect of airway remodeling and hyperresponsiveness on complexity of breathing pattern in rat.
Topics: Airway Remodeling; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Inflammation; Male; Methacholine Chloride; Random Allocation; Rats, Sprague-Dawley; Respiration; Respiratory Hypersensitivity; Specific Pathogen-Free Organisms | 2018 |
Role of prostaglandin E
Topics: 16,16-Dimethylprostaglandin E2; Animals; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cough; Cysteine; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Epoprostenol; Guinea Pigs; Leukotrienes; Male; Methacholine Chloride; Receptors, Prostaglandin E | 2018 |
Ghrelin Ameliorates Asthma by Inhibiting Endoplasmic Reticulum Stress.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Endoplasmic Reticulum; Ghrelin; Keratins; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Stress, Physiological | 2017 |
Respiratory dysfunction progresses with age in Kcna1-null mice, a model of sudden unexpected death in epilepsy.
Topics: Animals; Apnea; Bronchoconstrictor Agents; Death, Sudden; Disease Models, Animal; Disease Progression; Epilepsy; Epilepsy, Temporal Lobe; Gene Expression; Hyperventilation; Hypoxia; Kv1.1 Potassium Channel; Methacholine Chloride; Mice; Mice, Knockout; Muscle, Smooth; Respiratory Insufficiency; Reverse Transcriptase Polymerase Chain Reaction; Tachypnea; Tidal Volume; Trachea | 2018 |
Prophylactic effect of rosmarinic acid on tracheal responsiveness, white blood cell count and oxidative stress markers in lung lavage of sensitized rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Bronchoalveolar Lavage Fluid; Cinnamates; Depsides; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Leukocytes; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Ovalbumin; Oxidative Stress; Rats, Wistar; Respiratory Hypersensitivity; Rosmarinic Acid; Trachea | 2018 |
Essential oil of Croton Zehntneri attenuates lung injury in the OVA-induced asthma model.
Topics: Animals; Asthma; Brazil; Croton; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Lung; Lung Injury; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Oils, Volatile; Ovalbumin; Phytotherapy; Plant Leaves; Respiratory Mechanics | 2019 |
Quantitative Imaging of Regional Aerosol Deposition, Lung Ventilation and Morphology by Synchrotron Radiation CT.
Topics: Administration, Inhalation; Aerosols; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Humans; Iodine; Lung; Methacholine Chloride; Multimodal Imaging; Pulmonary Ventilation; Rabbits; Synchrotrons; Tomography, X-Ray Computed | 2018 |
Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion.
Topics: Animals; Asthma; Disease Models, Animal; DNA Methylation; Female; Gene Deletion; Gene Expression Regulation; Immunoglobulin E; Lipid Metabolism; Liver; Lung; Male; MAP Kinase Signaling System; Membrane Proteins; Methacholine Chloride; Mice, Inbred C57BL; Mice, Knockout; Organ Specificity; Phenotype; Promoter Regions, Genetic; Respiratory Hypersensitivity; Sex Characteristics; Sphingolipids; Transcriptome | 2018 |
Variable ventilation decreases airway responsiveness and improves ventilation efficiency in a rat model of asthma.
Topics: Air Pressure; Animals; Asthma; Disease Models, Animal; Male; Methacholine Chloride; Oxygen; Plethysmography, Whole Body; Random Allocation; Rats, Sprague-Dawley; Respiration; Respiration, Artificial; Specific Pathogen-Free Organisms; Tidal Volume | 2018 |
Immunomodulatory innate defence regulator (IDR) peptide alleviates airway inflammation and hyper-responsiveness.
Topics: Animals; Antimicrobial Cationic Peptides; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Cell Culture Techniques; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Female; Humans; Immunomodulation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pyroglyphidae; Respiratory Hypersensitivity | 2018 |
Bacterial respiratory tract inflammation in neonatal rat model is attenuated by benzofuran through inhibition of GATA3.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Benzofurans; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; GATA3 Transcription Factor; Histocytochemistry; Inflammation; Lung; Methacholine Chloride; Rats; Serum; Treatment Outcome | 2018 |
Anti-thymic stromal lymphopoietin antibody suppresses airway remodeling in asthma through reduction of MMP and CTGF.
Topics: Airway Remodeling; Animals; Antibodies, Monoclonal; Asthma; Connective Tissue Growth Factor; Cytokines; Disease Models, Animal; Female; Immunoglobulin E; Inflammation; Lung; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Plethysmography; Thymic Stromal Lymphopoietin; Transforming Growth Factor beta | 2019 |
Effect of nintedanib on airway inflammation in a mouse model of acute asthma.
Topics: Acute Disease; Administration, Inhalation; Administration, Oral; Airway Remodeling; Airway Resistance; Animals; Anti-Asthmatic Agents; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Glucocorticoids; Humans; Indoles; Inflammation Mediators; Methacholine Chloride; Mice; Ovalbumin | 2020 |
Effect of High-fat Diet on Tracheal Responsiveness to Methacholine and Insulin Resistance Index in Ovalbumin-sensitized Male and Female Rats.
Topics: Allergens; Animals; Asthma; Blood Glucose; Bronchoconstrictor Agents; Diet, High-Fat; Disease Models, Animal; Female; Insulin; Insulin Resistance; Male; Methacholine Chloride; Obesity; Ovalbumin; Rats, Wistar; Trachea | 2019 |
Caveolin-1 scaffolding domain peptide prevents hyperoxia-induced airway remodeling in a neonatal mouse model.
Topics: Airway Remodeling; Animals; Animals, Newborn; Anti-Inflammatory Agents; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Caveolin 1; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Hyperoxia; Injections, Intraperitoneal; Lung; Male; Membrane Proteins; Methacholine Chloride; Mice; Oxygen; Peptide Fragments; RNA-Binding Proteins; Signal Transduction | 2019 |
Genetic Deletion of Semaphorin 3E Aggravates Airway Contraction in a Mouse Model of Allergic Asthma.
Topics: Administration, Intranasal; Animals; Asthma; Bronchoconstriction; Cytoskeletal Proteins; Disease Models, Animal; Gene Deletion; Gene Expression; Lung; Membrane Proteins; Methacholine Chloride; Mice; Mice, Knockout; Microtomy; Pyroglyphidae; Recombinant Proteins; Semaphorins; Signal Transduction | 2019 |
Complement factor C5 inhibition reduces type 2 responses without affecting group 2 innate lymphoid cells in a house dust mite induced murine asthma model.
Topics: Animals; Asthma; Complement C5a; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Immunity, Innate; Lymphocytes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pyroglyphidae; Th2 Cells | 2019 |
Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma.
Topics: Adolescent; Adult; Animals; Asthma; Disease Models, Animal; Eflornithine; Female; Humans; Hypersensitivity; Inflammation; Lung; Male; Methacholine Chloride; Mice; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Ovalbumin; Polyamines; Spermine; Sputum; Young Adult | 2013 |
Treatment responses of procaterol and CD38 inhibitors in an ozone-induced airway hyperresponsiveness mice model.
Topics: ADP-ribosyl Cyclase 1; Animals; Anti-Asthmatic Agents; Benzoates; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Indoles; Leukocyte Count; Lung; Male; Membrane Glycoproteins; Methacholine Chloride; Mice; NF-kappa B; Ozone; Procaterol | 2013 |
Assessment of airway hyperresponsiveness in mouse models of allergic lung disease using detailed measurements of respiratory mechanics.
Topics: Animals; Asthma; Disease Models, Animal; Humans; Hypersensitivity; Lung; Methacholine Chloride; Mice; Respiratory Mechanics | 2013 |
Differential effects of allergen challenge on large and small airway reactivity in mice.
Topics: Airway Remodeling; Allergens; Animals; Antibody Specificity; Bronchial Hyperreactivity; Bronchial Provocation Tests; Calcium; Dinoprostone; Disease Models, Animal; Female; Immunoglobulin E; Inflammation; Methacholine Chloride; Mice; Ovalbumin | 2013 |
Abr, a negative regulator of Rac, attenuates cockroach allergen-induced asthma in a mouse model.
Topics: Adoptive Transfer; Allergens; Animals; Asthma; CD4-Positive T-Lymphocytes; Cell Movement; Chemokine CCL21; Disease Models, Animal; Eosinophils; GTPase-Activating Proteins; Immunoglobulin E; Interleukin-4; Interleukin-5; Lung; Methacholine Chloride; Mice; Mice, Knockout; rac GTP-Binding Proteins | 2013 |
Re-challenge with ovalbumin failed to induce bronchial asthma in mice with eosinophilic bronchitis.
Topics: Administration, Intranasal; Aerosols; Animals; Asthma; Bronchial Hyperreactivity; Bronchitis; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Female; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Pulmonary Eosinophilia | 2013 |
Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways.
Topics: Animals; Bronchial Hyperreactivity; Bronchiectasis; Bronchoconstrictor Agents; Cilia; Ciliary Motility Disorders; Disease Models, Animal; Methacholine Chloride; Mice; Mice, Knockout; Mucociliary Clearance; Respiratory Mucosa; Tumor Suppressor Proteins | 2014 |
B-lymphocytes as key players in chemical-induced asthma.
Topics: Animals; Asthma; B-Lymphocyte Subsets; B7-1 Antigen; B7-2 Antigen; Bronchoconstrictor Agents; CD40 Antigens; Disease Models, Animal; Immunoglobulin E; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, SCID; Toluene 2,4-Diisocyanate | 2013 |
Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis.
Topics: Activating Transcription Factor 6; Animals; Apoptosis; Bronchi; Caspase 3; Cell Line; Cells, Cultured; Collagen; Disease Models, Animal; Endoplasmic Reticulum Stress; Epithelial Cells; Humans; In Vitro Techniques; Methacholine Chloride; Mice; Mice, Inbred BALB C; Protein Disulfide-Isomerases; Pulmonary Fibrosis; Pyroglyphidae; RNA, Small Interfering | 2013 |
Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cell Differentiation; Diet; Disease Models, Animal; Female; Lung; Methacholine Chloride; Mice; Mice, Knockout; Muscle, Smooth; Oligonucleotide Array Sequence Analysis; Phenotype; Pregnancy; Signal Transduction; Tretinoin; Vitamin A; Vitamin A Deficiency | 2014 |
Bronchial responsiveness in an elastase-induced mouse model of emphysema.
Topics: Animals; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Emphysema; Lung; Male; Methacholine Chloride; Mice; Pancreatic Elastase; Pulmonary Alveoli; Pulmonary Atelectasis; Respiration, Artificial; Respiratory Mechanics; Thorax | 2014 |
Cyclophosphamide-induced alterations of the micturition reflex in a novel in situ urinary bladder model in the anesthetized rat.
Topics: Adenosine Triphosphate; Afferent Pathways; Animals; Cyclophosphamide; Cystitis; Disease Models, Animal; Dose-Response Relationship, Drug; Efferent Pathways; Electric Stimulation; Male; Mechanotransduction, Cellular; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Pressure; Rats, Sprague-Dawley; Reflex; Time Factors; Urinary Bladder; Urination | 2015 |
Neonatal oxygen exposure alters airway hyper-responsiveness but not the response to allergen challenge in adult mice.
Topics: Age Factors; Airway Resistance; Animals; Animals, Newborn; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Female; Hyperoxia; Lung; Lung Compliance; Male; Methacholine Chloride; Mice, Inbred C57BL; Molecular Sequence Data; Ovalbumin; Pneumonia; Risk Factors; Sex Factors | 2014 |
Naringenin inhibits allergen‑induced airway remodeling in a murine model of asthma.
Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Differentiation; Chronic Disease; Cytokines; Disease Models, Animal; Female; Fibrosis; Flavanones; Immunoglobulin E; Inflammation; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucus; Ovalbumin; Th2 Cells | 2014 |
ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma.
Topics: Activating Transcription Factor 6; Airway Remodeling; Allergens; Animals; Antibody Specificity; Asthma; Bronchial Hyperreactivity; Chemokines, CC; Chemokines, CXC; Cytokines; Disease Models, Animal; eIF-2 Kinase; Eosinophils; Gene Expression; Gene Order; Gene Targeting; Humans; Immunoglobulin E; Inflammation; Lung; Membrane Proteins; Methacholine Chloride; Mice; Mice, Transgenic; Ovalbumin; Th2 Cells; Transgenes; Unfolded Protein Response | 2014 |
Superiority of pulmonary administration of mepenzolate bromide over other routes as treatment for chronic obstructive pulmonary disease.
Topics: Airway Resistance; Animals; Anti-Inflammatory Agents; Benzilates; Disease Models, Animal; Drug Administration Routes; Drug Monitoring; Heart Rate; Male; Methacholine Chloride; Mice; Piperidines; Pulmonary Disease, Chronic Obstructive | 2014 |
Comprehensive multiplexed protein quantitation delineates eosinophilic and neutrophilic experimental asthma.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Biomarkers; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Female; Hydrocortisone; Inflammation; Inflammation Mediators; Leukocyte Count; Lipopolysaccharides; Mass Spectrometry; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; Phenotype; Protein Array Analysis; Proteome; Respiratory Mechanics | 2014 |
Steroids and antihistamines synergize to inhibit rat's airway smooth muscle contractility.
Topics: Animals; Cetirizine; Cholinergic Agents; Disease Models, Animal; Drug Synergism; Electric Stimulation; Glucocorticoids; Histamine Antagonists; Humans; Lung Diseases, Obstructive; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Prednisolone; Rats; Rhinitis, Allergic; Trachea; Treatment Outcome | 2015 |
Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis.
Topics: Animals; Animals, Newborn; Anions; Cilia; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Exocrine Glands; Lung; Methacholine Chloride; Mucociliary Clearance; Mucus; Respiratory Mucosa; Respiratory System; Swine; Trachea | 2014 |
Angiogenesis and airway reactivity in asthmatic Brown Norway rats.
Topics: Airway Resistance; Analysis of Variance; Animals; Asthma; Bronchial Arteries; Bronchial Hyperreactivity; Disease Models, Animal; DNA Primers; Fluorocarbons; Lung; Magnetic Resonance Imaging; Methacholine Chloride; Nanoparticles; Neovascularization, Pathologic; Pyroglyphidae; Rats; Real-Time Polymerase Chain Reaction; Silicone Elastomers; Time Factors | 2015 |
Effects of inhaled L-arginine administration in a murine model of acute asthma.
Topics: Acute Disease; Animals; Arginine; Asthma; Bronchoconstrictor Agents; Bronchodilator Agents; Budesonide; Disease Models, Animal; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nitric Oxide; Time Factors | 2014 |
The orl rat is more responsive to methacholine challenge than wild type.
Topics: Administration, Inhalation; Albuterol; Animals; Anti-Asthmatic Agents; Asthma; Bronchoconstrictor Agents; Cryptorchidism; Disease Models, Animal; Dose-Response Relationship, Drug; Interleukin-4; Interleukin-6; Lung; Male; Methacholine Chloride; Rats, Long-Evans; Tumor Necrosis Factor-alpha | 2014 |
Effects of immunomodulatory supplementation with Lactobacillus rhamnosus on airway inflammation in a mouse asthma model.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Immunoglobulin E; Lacticaseibacillus rhamnosus; Lung; Matrix Metalloproteinase 9; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Probiotics | 2016 |
Plp1 gene duplication inhibits airway responsiveness and induces lung inflammation.
Topics: Albuterol; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gene Duplication; Interleukin-6; Male; Methacholine Chloride; Mice; Myelin Proteolipid Protein; Pelizaeus-Merzbacher Disease; Pneumonia; Respiratory Mechanics | 2015 |
Syk mediates airway contractility independent of leukocyte function.
Topics: Air Pollutants; Airway Resistance; Animals; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Gene Deletion; Intracellular Signaling Peptides and Proteins; Leukocytes; Methacholine Chloride; Mice; Mice, Knockout; Particulate Matter; Phenotype; Protein-Tyrosine Kinases; Respiratory Hypersensitivity; Syk Kinase | 2015 |
Delivered dose estimate to standardize airway hyperresponsiveness assessment in mice.
Topics: Administration, Inhalation; Aerosols; Animals; Disease Models, Animal; Humans; Male; Methacholine Chloride; Mice; Nebulizers and Vaporizers; Reference Standards; Research Design; Respiratory Hypersensitivity | 2015 |
The Effect of Zataria multiflora and its Constituent, Carvacrol, on Tracheal Responsiveness and Lung Pathology in Guinea Pig Model of COPD.
Topics: Animals; Cymenes; Dexamethasone; Disease Models, Animal; Female; Guinea Pigs; Lamiaceae; Lung; Male; Methacholine Chloride; Monoterpenes; Nicotiana; Plant Extracts; Pulmonary Disease, Chronic Obstructive; Smoke; Trachea | 2015 |
Local Change in Urinary Bladder Contractility Following CNS Dopamine Denervation in the 6-OHDA Rat Model of Parkinson's Disease.
Topics: Adenosine Triphosphate; Animals; Corpus Striatum; Denervation; Disease Models, Animal; Dopaminergic Neurons; Electric Stimulation; Male; Methacholine Chloride; Muscarinic Agonists; Muscle Contraction; Oxidopamine; Parkinsonian Disorders; Purinergic Agents; Rats; Rats, Sprague-Dawley; Urinary Bladder | 2015 |
Chronic neurokinin-1 receptor antagonism fails to ameliorate clinical signs, airway hyper-responsiveness or airway eosinophilia in an experimental model of feline asthma.
Topics: Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cat Diseases; Cats; Disease Models, Animal; Eosinophilia; Methacholine Chloride; Neurokinin-1 Receptor Antagonists; Prospective Studies; Random Allocation; Receptors, Neurokinin-1 | 2016 |
Emodin mitigates diesel exhaust particles-induced increase in airway resistance, inflammation and oxidative stress in mice.
Topics: Airway Resistance; Animals; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Emodin; Glutathione; Lipid Peroxidation; Lung; Lung Diseases; Methacholine Chloride; Mice; Mice, Inbred BALB C; Muscarinic Agonists; Oxidative Stress; Particulate Matter; Pneumonia; Protein Kinase Inhibitors; Reactive Oxygen Species; Time Factors | 2015 |
Vitamin E Isoform γ-Tocotrienol Downregulates House Dust Mite-Induced Asthma.
Topics: Allergens; alpha-Tocopherol; Animals; Anti-Inflammatory Agents; Antioxidants; Asthma; Bronchoalveolar Lavage Fluid; Chromans; Cytokines; Dermatophagoides pteronyssinus; Disease Models, Animal; Eosinophils; Female; Gene Expression; Immunoglobulin E; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Prednisolone; Reactive Oxygen Species; Vitamin E | 2015 |
Altered lung function at mid-adulthood in mice following neonatal exposure to hyperoxia.
Topics: Animals; Animals, Newborn; Body Weight; Bronchoconstrictor Agents; Disease Models, Animal; Female; Hyperoxia; Lung; Lung Volume Measurements; Male; Methacholine Chloride; Mice, Inbred C57BL; Sex Characteristics | 2015 |
Mechanical consequences of allergic induced remodeling on mice airway resistance and compressibility.
Topics: Acute Disease; Airway Remodeling; Airway Resistance; Animals; Bronchoconstrictor Agents; Chronic Disease; Disease Models, Animal; Elasticity; Female; Goblet Cells; Methacholine Chloride; Mice, Inbred BALB C; Muscle, Smooth, Vascular; Ovalbumin; Pulmonary Ventilation; Random Allocation; Respiratory Hypersensitivity; Tidal Volume | 2015 |
Peripheral Airway Smooth Muscle, but Not the Trachealis, Is Hypercontractile in an Equine Model of Asthma.
Topics: Actin Cytoskeleton; Animals; Asthma; Blotting, Western; Ca(2+) Mg(2+)-ATPase; Contractile Proteins; Disease Models, Animal; Female; Horse Diseases; Horses; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Myofibrils; Myosin Heavy Chains; Myosins; Respiratory Mechanics; Trachea | 2016 |
Effects of antenatal lipopolysaccharide and postnatal hyperoxia on airway reactivity and remodeling in a neonatal mouse model.
Topics: Airway Remodeling; Animals; Animals, Newborn; Body Weight; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Elastin; Female; Hyperoxia; Inflammation; Lipopolysaccharides; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Oxygen; Pregnancy; Pregnancy, Animal; Respiration; Respiratory System | 2016 |
Pharmacological targeting of histamine H4 receptor in periodontal disease.
Topics: Alveolar Bone Loss; Alveolar Process; Animals; Apoptosis; Disease Models, Animal; Gingiva; Histamine Antagonists; Indoles; Male; Methacholine Chloride; Molecular Targeted Therapy; Periodontal Diseases; Periodontitis; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Submandibular Gland | 2016 |
Weight Loss Decreases Inherent and Allergic Methacholine Hyperresponsiveness in Mouse Models of Diet-Induced Obese Asthma.
Topics: Animals; Asthma; Bacteria; Bariatric Surgery; Bronchial Hyperreactivity; Cytokines; Diet; Disease Models, Animal; Hypersensitivity; Inflammation Mediators; Intestines; Male; Methacholine Chloride; Mice, Inbred C57BL; Mice, Obese; Obesity; Weight Loss | 2016 |
Sex-related differences in long-term pulmonary outcomes of neonatal hyperoxia in mice.
Topics: Animals; Animals, Newborn; Bronchioles; Bronchopulmonary Dysplasia; Disease Models, Animal; Female; Hyperoxia; Lung Compliance; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Oxygen; Pulmonary Alveoli; Receptors, Muscarinic; Respiratory Hypersensitivity; Respiratory Mucosa; Sex Characteristics | 2016 |
Downregulation of the cough reflex by aclidinium and tiotropium in awake and anesthetized rabbits.
Topics: Administration, Inhalation; Anesthesia; Animals; Antitussive Agents; Bronchoconstriction; Bronchodilator Agents; Cough; Delayed-Action Preparations; Disease Models, Animal; Male; Methacholine Chloride; Muscarinic Antagonists; Rabbits; Tiotropium Bromide; Tropanes; Wakefulness | 2016 |
Plethysmography Phenotype QTL in Mice Before and After Allergen Sensitization and Challenge.
Topics: Allergens; Animals; Asthma; Disease Models, Animal; Gene-Environment Interaction; Humans; Hypersensitivity; Immunization; Lung; Methacholine Chloride; Mice; Plethysmography; Pyroglyphidae; Quantitative Trait Loci | 2016 |
A novel peptide ADAM8 inhibitor attenuates bronchial hyperresponsiveness and Th2 cytokine mediated inflammation of murine asthmatic models.
Topics: ADAM Proteins; Animals; Antigens, CD; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Disease Models, Animal; Eosinophils; Gene Expression Regulation; Inflammation; Membrane Proteins; Methacholine Chloride; Mice, Inbred BALB C; Mice, Knockout; Peptides, Cyclic; Receptors, IgE; RNA, Messenger; Solubility; Th2 Cells | 2016 |
The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma.
Topics: Administration, Inhalation; Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Interleukin-17; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Mycobacterium phlei; Neutrophils; Ovalbumin; Receptors, Interleukin; Vaccines, Inactivated | 2017 |
Oral administration of Lactobacillus paracasei L9 attenuates PM2.5-induced enhancement of airway hyperresponsiveness and allergic airway response in murine model of asthma.
Topics: Administration, Oral; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Eosinophils; Female; Hypersensitivity; Immunotherapy; Lacticaseibacillus paracasei; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; Particulate Matter; Probiotics; Th1 Cells; Th2 Cells | 2017 |
Peri-adolescent asthma symptoms cause adult anxiety-related behavior and neurobiological processes in mice.
Topics: Age Factors; Animals; Anxiety; Asthma; Behavior, Animal; Disease Models, Animal; Female; Gene Expression; Hippocampus; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Muscarinic Agonists; Pyroglyphidae; Sex Factors | 2017 |
Immunologic regulatory effects of human umbilical cord blood-derived mesenchymal stem cells in a murine ovalbumin asthma model.
Topics: Allergens; Animals; Asthma; Cytokines; Disease Models, Animal; Female; Fetal Blood; Humans; Immunization; Immunoglobulin E; Immunomodulation; Inflammation Mediators; Lymph Nodes; Mesenchymal Stem Cells; Methacholine Chloride; Mice; Ovalbumin; Spleen; T-Lymphocyte Subsets | 2017 |
Allergen-induced airway hyperresponsiveness is absent in ecto-5'-nucleotidase (CD73)-deficient mice.
Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine; Allergens; Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Chlorides; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mucociliary Clearance; Ovalbumin; Trachea | 2008 |
Acute Influenza A infection induces bronchial hyper-responsiveness in mice.
Topics: Analysis of Variance; Animals; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cell Count; Cytokines; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Female; In Vitro Techniques; Influenza A virus; Influenza Vaccines; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Respiratory Hypersensitivity; Time Factors; Vascular Endothelial Growth Factor A | 2008 |
Time course of airway remodelling after an acute chlorine gas exposure in mice.
Topics: Animals; Apoptosis; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Proliferation; Chlorine; Disease Models, Animal; Gases; Goblet Cells; Lung; Male; Methacholine Chloride; Mice; Proliferating Cell Nuclear Antigen; Toxicity Tests, Acute | 2008 |
No effect of metformin on the innate airway hyperresponsiveness and increased responses to ozone observed in obese mice.
Topics: Administration, Oral; Animals; Asthma; Blood Glucose; Body Weight; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Chemokines; Diabetes Mellitus; Disease Models, Animal; Female; Hypoglycemic Agents; Inflammation Mediators; Metformin; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Obese; Neutrophil Infiltration; Obesity; Ozone; Phenotype; Respiratory Mechanics | 2008 |
Endothelin A receptor antagonist modulates lymphocyte and eosinophil infiltration, hyperreactivity and mucus in murine asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Endothelin A Receptor Antagonists; Eosinophils; Lung; Lymphocyte Subsets; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mucus; Ovalbumin; Peptides, Cyclic | 2008 |
Discovery of biphenyl piperazines as novel and long acting muscarinic acetylcholine receptor antagonists.
Topics: Administration, Intranasal; Animals; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Methacholine Chloride; Mice; Molecular Structure; Piperazines; Receptors, Muscarinic; Stereoisomerism; Structure-Activity Relationship | 2008 |
Immunoglobulin E antibodies enhance pulmonary inflammation induced by inhalation of a chemical hapten.
Topics: Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Count; Chemokine CCL2; Dinitrobenzenes; Disease Models, Animal; Eosinophils; Haptens; Immunization; Immunoglobulin E; Inflammation; Killer Cells, Natural; Lung; Metaplasia; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Natural Killer T-Cells; Occupational Diseases; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2009 |
Comparisons of effects of intravenous and inhaled methacholine on airway physiology in a murine asthma model.
Topics: Administration, Inhalation; Airway Resistance; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Female; Injections, Intravenous; Lung Compliance; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ovalbumin; Pneumonia; Respiration, Artificial | 2009 |
A hypoallergenic variant of Der p 1 as a candidate for mite allergy vaccines.
Topics: Allergens; Animals; Antigens, Dermatophagoides; Arthropod Proteins; Basophils; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cell Line, Tumor; Cloning, Molecular; Cysteine Endopeptidases; Disease Models, Animal; Eosinophilia; Female; Humans; Hypersensitivity; Immunoglobulin E; Interferon-gamma; Interleukin-5; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pyroglyphidae; Rats; Recombinant Proteins; T-Lymphocytes; Vaccines | 2009 |
Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model.
Topics: Alprenolol; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Epithelial Cells; Humans; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phenotype; Receptors, Adrenergic, beta-2; Signal Transduction | 2009 |
Effects of the phosphodiesterase type 4 inhibitor roflumilast on early and late allergic response and airway hyperresponsiveness in Aspergillus-fumigatus-sensitized mice.
Topics: Aminopyridines; Animals; Antigens, Fungal; Aspergillus fumigatus; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cyclopropanes; Disease Models, Animal; Eosinophils; Female; Leukocyte Count; Lymphocytes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Phosphodiesterase 4 Inhibitors; Pneumonia; Respiratory Hypersensitivity; Respiratory Mechanics | 2009 |
Impaired vascular function in mice with an active cytomegalovirus infection.
Topics: Animals; Arteries; beta-Galactosidase; Cytomegalovirus; Cytomegalovirus Infections; Disease Models, Animal; Female; Fetal Weight; Male; Mesentery; Methacholine Chloride; Mice; Mice, Inbred C57BL; Phenylephrine; Placenta; Pregnancy; Uterus; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2009 |
Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice.
Topics: Airway Resistance; Albuterol; Animals; Bronchial Hyperreactivity; Cells, Cultured; Disease Models, Animal; Early Growth Response Protein 1; ErbB Receptors; Fibroblasts; Humans; Hyperplasia; Lung; Lung Compliance; Methacholine Chloride; Mice; Mice, Knockout; Mice, Transgenic; Muscle, Smooth; Muscle, Smooth, Vascular; Pulmonary Artery; Pulmonary Fibrosis; Recombinant Fusion Proteins; Transforming Growth Factor alpha; Weight Loss | 2009 |
A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cell Count; Disease Models, Animal; Drug Delivery Systems; Heart Rate; Helium; Imaging, Three-Dimensional; Infusion Pumps; Lung; Magnetic Resonance Imaging; Methacholine Chloride; Mice; Ovalbumin; Pulmonary Ventilation; Reproducibility of Results; Time Factors | 2009 |
Altered regulation of aquaporin gene expression in allergen and IL-13-induced mouse models of asthma.
Topics: Animals; Aquaporin 1; Aquaporin 4; Aquaporin 5; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Female; Gene Expression Regulation; Inflammation; Interleukin-13; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Models, Biological | 2009 |
Subcutaneous prostaglandin E(2) restrains airway mast cell activity in vivo and reduces lung eosinophilia and Th(2) cytokine overproduction in house dust mite-sensitive mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Chemokine CCL2; Cytokines; Dinoprostone; Disease Models, Animal; Eosinophils; Female; Infusions, Subcutaneous; Lung; Mast Cells; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pulmonary Eosinophilia; Pyroglyphidae; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Th2 Cells | 2009 |
Is toluene diamine a sensitizer and is there cross-reactivity between toluene diamine and toluene diisocyanate?
Topics: Animals; Antigens, CD; Asthma; Cells, Cultured; Cross Reactions; Cytokines; Disease Models, Animal; Immunoglobulins; Local Lymph Node Assay; Lymphocytes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Phenylenediamines; Statistics, Nonparametric; Toluene 2,4-Diisocyanate | 2009 |
The contribution of Ca2+ signaling and Ca2+ sensitivity to the regulation of airway smooth muscle contraction is different in rats and mice.
Topics: Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Calcium; Calcium Signaling; Disease Models, Animal; Male; Membrane Potentials; Methacholine Chloride; Mice; Mice, Inbred BALB C; Muscle, Smooth; Potassium Chloride; Protein Kinase C; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Serotonin; Species Specificity; Temperature; Trachea | 2009 |
Galpha13 regulates methacholine-induced contraction of bronchial smooth muscle via phosphorylation of MLC20.
Topics: Airway Resistance; Animals; Bronchi; Bronchoconstrictor Agents; Calcium; Cells, Cultured; Disease Models, Animal; GTP-Binding Protein alpha Subunits, G12-G13; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Ovalbumin; Phosphorylation; Respiratory Hypersensitivity; Trachea | 2009 |
Oropharyngeal aspiration: an alternative route for challenging in a mouse model of chemical-induced asthma.
Topics: Administration, Intranasal; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; Eosinophils; Immunoglobulin E; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Respiratory Aspiration; Toluene 2,4-Diisocyanate; Up-Regulation | 2009 |
Airway hyperresponsiveness is associated with activated CD4+ T cells in the airways.
Topics: Airway Resistance; Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Disease Models, Animal; Female; Immunoglobulin E; Immunoglobulin G; Lectins, C-Type; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ovalbumin; Specific Pathogen-Free Organisms | 2009 |
Methacholine and ovalbumin challenges assessed by forced oscillations and synchrotron lung imaging.
Topics: Administration, Inhalation; Airway Resistance; Allergens; Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Image Processing, Computer-Assisted; Infusions, Intravenous; Lung; Lung Compliance; Methacholine Chloride; Oscillometry; Ovalbumin; Pulmonary Ventilation; Rabbits; Respiratory Mechanics; Synchrotrons; Tomography, X-Ray Computed | 2009 |
Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Humans; Immunoglobulin E; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ovalbumin | 2009 |
Aerosolized methacholine-induced bronchoconstriction and pulmonary hyperinflation in rats.
Topics: Administration, Inhalation; Aerosols; Animals; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Functional Residual Capacity; Lung; Lung Volume Measurements; Male; Methacholine Chloride; Plethysmography, Whole Body; Rats; Rats, Wistar | 2009 |
Peroxiredoxin I is a negative regulator of Th2-dominant allergic asthma.
Topics: Airway Resistance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Lung; Methacholine Chloride; Mice; Mice, Knockout; Nitric Oxide; Peroxiredoxins; T-Lymphocytes; Th2 Cells | 2009 |
The effects of repeated allergen challenge on airway smooth muscle structural and molecular remodeling in a rat model of allergic asthma.
Topics: Allergens; Animals; Asthma; Blotting, Western; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Disease Models, Animal; Male; Methacholine Chloride; Muscle, Smooth; Ovalbumin; Rats; Rats, Inbred BN; Receptor, Muscarinic M3; Respiratory System; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2009 |
Galectin-9 in allergic airway inflammation and hyper-responsiveness in mice.
Topics: Allergens; Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cell Movement; Cytokines; Dexamethasone; Disease Models, Animal; Female; Galectins; Granulocytes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Ovalbumin; Respiratory Function Tests | 2010 |
Airway responsiveness and bronchoalveolar lavage fluid profiling in individual rats: effects of different ovalbumin exposures.
Topics: Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Methacholine Chloride; Neutrophils; Ovalbumin; Rats; Rats, Wistar; Respiratory Mechanics; Time Factors | 2010 |
Sensitization to inhaled ryegrass pollen by collateral priming in a murine model of allergic respiratory disease.
Topics: Airway Resistance; Animals; Antigens, Plant; Blotting, Western; Bronchial Hyperreactivity; Bronchial Provocation Tests; Disease Models, Animal; Gene Expression; Immunization; Immunoglobulin E; Immunoglobulin G; Inflammation; Interleukin-13; Interleukin-4; Interleukin-5; Lolium; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Plant Extracts; Plant Proteins; Pollen; Respiratory Hypersensitivity; Th2 Cells | 2010 |
Precapillary pulmonary hypertension leads to reversible bronchial hyperreactivity in rats.
Topics: Airway Resistance; Animals; Aorta, Abdominal; Blood Pressure; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Disease Models, Animal; Hypertension, Pulmonary; Male; Methacholine Chloride; Models, Biological; Oscillometry; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Respiratory Mechanics; Time Factors; Vena Cava, Inferior | 2010 |
Ammonium persulfate can initiate an asthmatic response in mice.
Topics: Ammonium Sulfate; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cell Proliferation; Cells, Cultured; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Immunoglobulin E; Lymph Nodes; Lymphocyte Activation; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C | 2010 |
Reversal of methylprednisolone effects in allergen-exposed female BALB/c mice.
Topics: Administration, Intranasal; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cyclosporine; Disease Models, Animal; Drug Antagonism; Female; Glucocorticoids; Immunosuppressive Agents; Injections, Intraperitoneal; Lung; Methacholine Chloride; Methylprednisolone; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Function Tests; Respiratory Hypersensitivity | 2010 |
Ozone increases airway hyperreactivity and mucus hyperproduction in mice previously exposed to allergen.
Topics: Air Pollutants; Allergens; Animals; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Interactions; Inhalation Exposure; Leukocyte Count; Leukocytes; Lung; Methacholine Chloride; Mice; Mucus; Ovalbumin; Ozone; Periodic Acid-Schiff Reaction; Respiratory Function Tests | 2010 |
Airway inflammation and remodeling in two mouse models of asthma: comparison of males and females.
Topics: Airway Remodeling; Animals; Asthma; Cytokines; Disease Models, Animal; Eosinophils; Female; Immunoglobulin E; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Pyroglyphidae; Sex Characteristics | 2010 |
Alveolar macrophages reduce airway hyperresponsiveness and modulate cytokine levels.
Topics: Allergens; Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cytokines; Disease Models, Animal; Interleukins; Macrophages, Alveolar; Male; Methacholine Chloride; Ovalbumin; Rats; Rats, Inbred BN; Rats, Sprague-Dawley; Time Factors; Tumor Necrosis Factor-alpha | 2010 |
Thalidomide attenuates airway hyperresponsiveness and eosinophilic inflammation in a murine model of allergic asthma.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Female; Goblet Cells; Hyperplasia; Inflammation; Interleukin-5; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Thalidomide; Tumor Necrosis Factor-alpha | 2010 |
Concomitant administration of nitric oxide and glucocorticoids improves protection against bronchoconstriction in a murine model of asthma.
Topics: Administration, Inhalation; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cyclic GMP; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Female; Glucocorticoids; Guanylate Cyclase; Hydrazines; Hydrocortisone; Injections, Intraperitoneal; Lipopolysaccharides; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Ovalbumin; Oxadiazoles; Pneumonia; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Receptors, Glucocorticoid; Respiration, Artificial; Respiratory Mechanics; Soluble Guanylyl Cyclase | 2010 |
Combined forced oscillation and forced expiration measurements in mice for the assessment of airway hyperresponsiveness.
Topics: Adrenal Cortex Hormones; Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Dexamethasone; Disease Models, Animal; Female; Forced Expiratory Flow Rates; Forced Expiratory Volume; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Oscillometry; Ovalbumin; Respiratory Function Tests; Respiratory Mechanics; Time Factors; Vital Capacity | 2010 |
Fractionation of swine barn dust and assessment of its impact on the respiratory tract following repeated airway exposure.
Topics: Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chemokines; Cytokines; Disease Models, Animal; Dust; Enzyme-Linked Immunosorbent Assay; Housing, Animal; Inflammation; Inhalation Exposure; Interleukin-1beta; Interleukin-6; Methacholine Chloride; Mice; Plethysmography; Respiratory System; Risk Assessment; Swine; Time Factors; Tumor Necrosis Factor-alpha | 2010 |
A comparison of the allergic responses induced by Penicillium chrysogenum and house dust mite extracts in a mouse model.
Topics: Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dose-Response Relationship, Immunologic; Hypersensitivity; Immunoglobulin E; Intubation, Intratracheal; L-Lactate Dehydrogenase; Methacholine Chloride; Mice; Mice, Inbred BALB C; Penicillium chrysogenum; Pyroglyphidae | 2010 |
IL-12-STAT4-IFN-gamma axis is a key downstream pathway in the development of IL-13-mediated asthma phenotypes in a Th2 type asthma model.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Interferon-gamma; Interleukin-12; Interleukin-12 Receptor beta 2 Subunit; Interleukin-13; Interleukin-4; Methacholine Chloride; Mice; Mice, Transgenic; Models, Immunological; Organ Specificity; Pneumonia; Receptors, Cell Surface; Signal Transduction; STAT4 Transcription Factor; Th2 Cells | 2010 |
Sex-specific lung remodeling and inflammation changes in experimental allergic asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Chronic Disease; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Matrix; Female; Inflammation Mediators; Interleukin-4; Interleukin-5; Lung; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Ovariectomy; Pneumonia; Sex Factors; Time Factors; Transforming Growth Factor beta | 2010 |
No role for neutrophil elastase in influenza-induced cellular recruitment, cytokine production or airway hyperresponsiveness in mice.
Topics: Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Chemokine CXCL2; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Leukocyte Elastase; Lung; Methacholine Chloride; Mice; Mice, Knockout; Orthomyxoviridae Infections; Statistics, Nonparametric; Tumor Necrosis Factor-alpha | 2010 |
Comprehensive analysis of elastase-induced pulmonary emphysema in mice: effects of ambient existing particulate matters.
Topics: Alkaline Phosphatase; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Hydro-Lyases; Interleukin-1beta; Lymphocytes; Macrophages; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Pancreatic Elastase; Particulate Matter; Pneumonia; Pulmonary Emphysema; Swine; Vehicle Emissions | 2010 |
Proteome analysis of multiple compartments in a mouse model of chemical-induced asthma.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Inflammation; Mass Spectrometry; Methacholine Chloride; Mice; Neutrophils; Oxidative Stress; Proteome; Toluene 2,4-Diisocyanate | 2010 |
Successful transfer of chemical-induced asthma by adoptive transfer of low amounts of lymphocytes in a mouse model.
Topics: Adoptive Transfer; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Immunoglobulin E; Lymphocytes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Time Factors; Toluene 2,4-Diisocyanate | 2011 |
Effects of oral monosodium glutamate in mouse models of asthma.
Topics: Administration, Oral; Animals; Asthma; Body Weight; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Eosinophils; Immunoglobulin E; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Sodium Glutamate; Trachea | 2011 |
The effects of inhaled house dust mite on airway barrier function and sensitivity to inhaled methacholine in mice.
Topics: Administration, Inhalation; Allergens; Animals; Antigens, Dermatophagoides; Dermatophagoides pteronyssinus; Disease Models, Animal; Female; Humans; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Models, Biological; Radiopharmaceuticals; Respiratory Hypersensitivity; Respiratory Mechanics; Technetium Tc 99m Pentetate; Tomography, Emission-Computed, Single-Photon | 2011 |
Reduced methacholine-induced submandibular salivary secretion in rats with experimental periodontitis.
Topics: Animals; Dinoprostone; Disease Models, Animal; Male; Methacholine Chloride; Nitric Oxide Synthase Type II; Periodontitis; Random Allocation; Rats; Rats, Wistar; Saliva; Salivation; Submandibular Gland | 2011 |
Toll-like receptor 2 regulates organic dust-induced airway inflammation.
Topics: Animal Husbandry; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Chemokines; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Dust; Housing, Animal; Inflammation Mediators; Inhalation Exposure; Lipopolysaccharides; Lung; Macrophages, Alveolar; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; Neutrophils; Nitric Oxide; Peptidoglycan; Pneumonia; Swine; Time Factors; Toll-Like Receptor 2 | 2011 |
Hesperidin suppresses ovalbumin-induced airway inflammation in a mouse allergic asthma model.
Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Hesperidin; Immunoglobulin E; Inflammation; Interleukin-13; Interleukin-4; Interleukin-5; Leukocytes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory System; Th2 Cells | 2012 |
Strain-dependent genomic factors affect allergen-induced airway hyperresponsiveness in mice.
Topics: Airway Resistance; Allergens; Animals; Antigens, Dermatophagoides; Arthropod Proteins; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cysteine Endopeptidases; Cytokines; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Genetic Predisposition to Disease; Immunoglobulin E; Immunoglobulin G; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mucins; Phenotype; Receptors, G-Protein-Coupled; Th2 Cells; Time Factors | 2011 |
ICOS ligand expression is essential for allergic airway hyperresponsiveness.
Topics: Animals; Bronchial Hyperreactivity; Cells, Cultured; Cytokines; Disease Models, Animal; Female; Humans; Immunity, Humoral; Immunization; Immunoglobulin E; Inducible T-Cell Co-Stimulator Ligand; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovalbumin; Proteins; Respiratory Hypersensitivity; Th17 Cells | 2011 |
Molecular model of naphthalene-induced DNA damage in the murine lung.
Topics: Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; DNA Breaks, Double-Stranded; Epithelial Cells; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mutagens; Naphthalenes | 2012 |
A single DH gene segment is sufficient for the establishment of an asthma phenotype in a murine model of allergic airway inflammation.
Topics: Allergens; Animals; Asthma; B-Lymphocytes; Bronchial Hyperreactivity; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hypersensitivity; Immunoglobulin E; Immunoglobulin G; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Ovalbumin | 2011 |
Effects of furosemide on allergic asthmatic responses in mice.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Furosemide; Goblet Cells; Hypersensitivity; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; T-Lymphocytes; Treatment Outcome | 2011 |
Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma.
Topics: Animals; Asthma; Bronchoalveolar Lavage; Chemokines; Disease Models, Animal; Gene Expression Regulation; Inflammation; Interferon-gamma; Lung; Mast Cells; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Biological; Oligonucleotide Array Sequence Analysis; Th1 Cells; Th2 Cells | 2011 |
S-nitrosoglutathione supplementation to ovalbumin-sensitized and -challenged mice ameliorates methacholine-induced bronchoconstriction.
Topics: Administration, Inhalation; Aerosols; Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Inflammation; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mucin 5AC; Ovalbumin; S-Nitrosoglutathione; Tracheotomy | 2011 |
Capsicum annuum L. methanolic extract inhibits ovalbumin-induced airway inflammation and oxidative stress in a mouse model of asthma.
Topics: Administration, Oral; Animals; Antioxidants; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Capsicum; Cytokines; Disease Models, Animal; Female; Fruit; Immunoglobulin E; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; NF-kappa B; Ovalbumin; Oxidative Stress; Plant Extracts; Reactive Oxygen Species; T-Lymphocytes, Helper-Inducer | 2011 |
Iron administration reduces airway hyperreactivity and eosinophilia in a mouse model of allergic asthma.
Topics: Allergens; Animals; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eosinophilia; Humans; Immunoglobulin E; Infant; Injections, Intraperitoneal; Iron; Iron-Dextran Complex; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phenanthrolines; Plethysmography | 2011 |
Effects of experimental asthma on inflammation and lung mechanics in sickle cell mice.
Topics: Airway Resistance; Anemia, Sickle Cell; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Colorimetry; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eosinophils; Hemoglobin A; Hemoglobin, Sickle; Humans; Immunoglobulin E; Inflammation Mediators; L-Lactate Dehydrogenase; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ovalbumin; Pneumonia; Positive-Pressure Respiration; Vascular Endothelial Growth Factor A | 2012 |
Effects of simulated downwind coal combustion emissions on pre-existing allergic airway responses in mice.
Topics: Air Pollutants; Animals; Antibodies; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Coal; Cytokines; Disease Models, Animal; Eosinophils; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; Particulate Matter; Pneumonia; Power Plants; Respiratory Hypersensitivity | 2011 |
Effects of maternal food restriction on offspring lung extracellular matrix deposition and long term pulmonary function in an experimental rat model.
Topics: Actins; Animals; Animals, Newborn; Caloric Restriction; Disease Models, Animal; Elastin; Extracellular Matrix; Female; Fetal Growth Retardation; Lung; Methacholine Chloride; Pregnancy; Prenatal Nutritional Physiological Phenomena; Rats; Rats, Sprague-Dawley | 2012 |
Inhibition of Pim1 kinase activation attenuates allergen-induced airway hyperresponsiveness and inflammation.
Topics: Allergens; Animals; Bronchoalveolar Lavage Fluid; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Female; Goblet Cells; Hypersensitivity; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Pneumonia; Proto-Oncogene Proteins c-pim-1; Respiratory Hypersensitivity | 2012 |
Hypertrophic airway smooth muscle mass correlates with increased airway responsiveness in a murine model of asthma.
Topics: Airway Resistance; Animals; Apoptosis; Asthma; Cell Proliferation; Disease Models, Animal; Female; Hypertrophy; Methacholine Chloride; Mice; Mice, Inbred BALB C; Muscle, Smooth; Ovalbumin; Respiratory Hypersensitivity | 2012 |
Assessment of peripheral airway function following chronic allergen challenge in a sheep model of asthma.
Topics: Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Separation; Chronic Disease; Disease Models, Animal; Eosinophils; Female; Lung; Methacholine Chloride; Pyroglyphidae; Sheep | 2011 |
Effects of corticosteroid treatment on airway inflammation, mechanics, and hyperpolarized ³He magnetic resonance imaging in an allergic mouse model.
Topics: Adrenal Cortex Hormones; Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchoconstrictor Agents; Dexamethasone; Disease Models, Animal; Elasticity; Helium; Hypersensitivity; Isotopes; Lung; Magnetic Resonance Imaging; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Models, Biological; Ovalbumin; Pulmonary Ventilation; Respiratory Mechanics | 2012 |
Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB.
Topics: Airway Resistance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Adhesion Molecules; Cell Count; Chemokines; Chitinases; Cytokines; Disease Models, Animal; DNA-Binding Proteins; Dose-Response Relationship, Drug; Female; Flavonoids; Flavonols; Genes, Reporter; Inflammation; Inflammation Mediators; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucin 5AC; Mucus; NF-kappa B; Nitric Oxide Synthase Type II; Ovalbumin; Protein Transport; Tumor Necrosis Factor-alpha | 2012 |
Chloride secretion by cultures of pig tracheal gland cells.
Topics: Amiloride; Animals; Biomarkers; Calcium; Cells, Cultured; Chlorides; Cyclic AMP; Cystic Fibrosis; Diffusion Chambers, Culture; Disease Models, Animal; Electric Impedance; Epithelial Cells; Exocrine Glands; Humans; Ion Transport; Lactoferrin; Methacholine Chloride; Mucin-5B; Muramidase; Swine; Tight Junctions; Trachea | 2012 |
Airway responsiveness depends on the diffusion rate of methacholine across the airway wall.
Topics: Administration, Inhalation; Aerosols; Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Computer Simulation; Diffusion; Disease Models, Animal; Dose-Response Relationship, Drug; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Models, Biological; Muscle, Smooth; Ovalbumin; Permeability | 2012 |
IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction.
Topics: Analysis of Variance; Animals; Asthma; CD11c Antigen; CD4 Antigens; Dendritic Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Humans; In Vitro Techniques; Integrin alphaV; Interleukin-17; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Ovalbumin; Potassium Chloride; Respiratory System; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Th17 Cells | 2012 |
Discovery of a novel orally active PDE-4 inhibitor effective in an ovalbumin-induced asthma murine model.
Topics: Administration, Oral; Animals; Anti-Asthmatic Agents; Asthma; Benzoates; Bronchial Hyperreactivity; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophil Peroxidase; Female; Ferrets; Guinea Pigs; Inhibitory Concentration 50; Lipopolysaccharides; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phosphodiesterase 4 Inhibitors; Pyrazoles; Rats; Rats, Sprague-Dawley | 2012 |
Bronchoprotection in conscious guinea pigs by budesonide and the NO-donating analogue, TPI 1020, alone and combined with tiotropium or formoterol.
Topics: Administration, Inhalation; Animals; Bronchoconstriction; Bronchodilator Agents; Budesonide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethanolamines; Formoterol Fumarate; Guinea Pigs; Histamine; Male; Methacholine Chloride; Respiratory Tract Diseases; Scopolamine Derivatives; Time Factors; Tiotropium Bromide | 2012 |
Corticosteroid treatment inhibits airway hyperresponsiveness and lung injury in a murine model of chemical-induced airway inflammation.
Topics: Animals; Anti-Inflammatory Agents; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Collagen; Dexamethasone; Disease Models, Animal; Female; Glucocorticoids; Inflammation; Lung; Lung Injury; Macrophages; Melphalan; Methacholine Chloride; Mice; Mice, Inbred C57BL; Neutrophils; Time Factors | 2012 |
Protein kinase C epsilon is important in modulating organic-dust-induced airway inflammation.
Topics: Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Chemokines; Disease Models, Animal; Dust; Environmental Exposure; Enzyme Activation; Female; Inflammation Mediators; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; Protein Kinase C-epsilon; T-Lymphocytes | 2012 |
Caveolin-1 knockout mice exhibit airway hyperreactivity.
Topics: Animals; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Calcium; Caveolin 1; Disease Models, Animal; Methacholine Chloride; Mice; Mice, Inbred Strains; Mice, Knockout; Muscle, Smooth; Ovalbumin; Receptors, Cell Surface; Receptors, Tumor Necrosis Factor, Type I; Respiratory Mucosa | 2012 |
Spleen tyrosine kinase inhibition attenuates airway hyperresponsiveness and pollution-induced enhanced airway response in a chronic mouse model of asthma.
Topics: Air Pollutants; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cells, Cultured; Disease Models, Animal; Female; Humans; Inflammation; Intracellular Signaling Peptides and Proteins; Keratinocytes; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Respiratory Mucosa; Syk Kinase; Vascular Endothelial Growth Factor A | 2013 |
Variation in airway responsiveness of male C57BL/6 mice from 5 vendors.
Topics: Airway Resistance; Animal Feed; Animals; Animals, Laboratory; Asthma; Breeding; Bronchoconstrictor Agents; Commerce; Disease Models, Animal; Environment; Genetic Variation; Housing, Animal; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Species Specificity | 2012 |
Effect of the fungal immunomodulatory protein FIP-fve on airway inflammation and cytokine production in mouse asthma model.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Fungal Proteins; Inflammation; Inflammation Mediators; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory System; Th1 Cells; Th2 Cells | 2013 |
CD4+CD25+Foxp3+ T cells contribute to the antiasthmatic effects of Astragalus membranaceus extract in a rat model of asthma.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Astragalus propinquus; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Forkhead Transcription Factors; Male; Methacholine Chloride; Ovalbumin; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; RNA, Messenger; T-Lymphocytes, Regulatory | 2013 |
Prevention of airway hyperresponsiveness induced by left ventricular dysfunction in rats.
Topics: Airway Resistance; Angiotensin-Converting Enzyme Inhibitors; Animals; Arterial Pressure; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Calcium Channel Blockers; Disease Models, Animal; Diuretics; Drug Therapy, Combination; Hypertension, Pulmonary; Lung; Lung Volume Measurements; Male; Methacholine Chloride; Myocardial Ischemia; Plethysmography; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Time Factors; Ventricular Dysfunction, Left; Ventricular Function, Left | 2012 |
Latex sensitization by dermal exposure can lead to airway hyperreactivity.
Topics: Administration, Cutaneous; Allergens; Animals; Bronchial Hyperreactivity; Disease Models, Animal; Female; Gloves, Protective; Immunoglobulin E; Latex; Latex Hypersensitivity; Methacholine Chloride; Mice; Mice, Inbred BALB C; Proteins | 2002 |
Interleukin-1beta-induced airway hyperresponsiveness enhances substance P in intrinsic neurons of ferret airway.
Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Disease Models, Animal; Electric Stimulation; Ferrets; Instillation, Drug; Interleukin-1; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Neurons; Substance P; Trachea | 2002 |
Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice.
Topics: Animals; Antigens; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Calcitonin Gene-Related Peptide; Crosses, Genetic; Disease Models, Animal; DNA; Female; Genomic Library; Genotype; Immunohistochemistry; Leukocyte Count; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovalbumin | 2002 |
Reduction of the internal atrial defibrillation threshold with balanced orthogonal sequential shocks.
Topics: Animals; Atrial Fibrillation; Defibrillators, Implantable; Differential Threshold; Disease Models, Animal; Electric Countershock; Electric Impedance; Electrodes, Implanted; Heart Atria; Heart Conduction System; Methacholine Chloride; Models, Cardiovascular; Parasympathomimetics; Sheep; Treatment Outcome; Vena Cava, Superior | 2002 |
Antiinflammatory effects of genistein, a tyrosine kinase inhibitor, on a guinea pig model of asthma.
Topics: Analysis of Variance; Animals; Asthma; Blotting, Western; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Dexamethasone; Disease Models, Animal; Enzyme Inhibitors; Genistein; Guinea Pigs; Immunohistochemistry; Injections, Intraperitoneal; Male; Methacholine Chloride; Probability; Random Allocation; Reference Values; Trachea; Treatment Outcome | 2003 |
Disruption of L-histidine decarboxylase reduces airway eosinophilia but not hyperresponsiveness.
Topics: Administration, Inhalation; Airway Resistance; Animals; Asthma; Bone Marrow Cells; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eosinophilia; Eosinophils; Histamine; Histidine Decarboxylase; Immunoblotting; Interleukin-5; Leukocyte Count; Lung; Male; Methacholine Chloride; Mice; Mice, Knockout; Ovalbumin; Pulmonary Eosinophilia; Selectins; Time Factors | 2003 |
An improved porcine model of stable methacholine-induced bronchospasm.
Topics: Animals; Asthma; Bronchial Spasm; Disease Models, Animal; Methacholine Chloride; Reproducibility of Results; Respiration, Artificial; Respiratory Mechanics; Swine; Ventilation-Perfusion Ratio | 2003 |
A broad-spectrum caspase inhibitor attenuates allergic airway inflammation in murine asthma model.
Topics: Aerosols; Allergens; Amino Acid Chloromethyl Ketones; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Caspase Inhibitors; Cell Movement; Cysteine Proteinase Inhibitors; Disease Models, Animal; Inflammation; Interleukin-4; Interleukin-5; Intubation, Intratracheal; Leukocytes; Lung; Lymphocyte Activation; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; T-Lymphocytes | 2003 |
The role of L-carnitine in treatment of a murine model of asthma.
Topics: Animals; Asthma; Carnitine; Disease Models, Animal; Leukotriene E4; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Oxygen | 2002 |
Chlorine-induced injury to the airways in mice.
Topics: Administration, Inhalation; Animals; Asthma; Bronchoconstrictor Agents; Chemical Warfare Agents; Chlorine; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Methacholine Chloride; Mice; Respiratory System; Severity of Illness Index; Time Factors | 2003 |
Effects of helium-oxygen on respiratory mechanics, gas exchange, and ventilation-perfusion relationships in a porcine model of stable methacholine-induced bronchospasm.
Topics: Acute Disease; Animals; Asthma; Bronchial Spasm; Bronchoconstrictor Agents; Disease Models, Animal; Helium; Methacholine Chloride; Oxygen Inhalation Therapy; Pulmonary Gas Exchange; Respiration, Artificial; Respiratory Mechanics; Swine; Treatment Outcome; Ventilation-Perfusion Ratio | 2003 |
Mycobacterium vaccae administration during allergen sensitization or challenge suppresses asthmatic features.
Topics: Allergens; Animals; Asthma; Bacterial Vaccines; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; Immunoglobulins; Leukocyte Count; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mycobacterium; Ovalbumin; Pulmonary Eosinophilia | 2003 |
Airway eosinophil accumulation on sensory neuropeptide release in a guinea pig model of distilled-water-induced bronchoconstriction.
Topics: Aerosols; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Disease Models, Animal; Eosinophils; Guinea Pigs; Immunization, Passive; Male; Methacholine Chloride; Piperidines; Platelet Activating Factor; Quinuclidines; Substance P; Water | 2003 |
Effects of fexofenadine on T-cell function in a murine model of allergen-induced airway inflammation and hyperresponsiveness.
Topics: Administration, Inhalation; Adoptive Transfer; Allergens; Animals; Anti-Allergic Agents; Antibody Specificity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Female; Histamine H1 Antagonists; Immunoglobulin E; Injections, Intraperitoneal; Leukocyte Count; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Hypersensitivity; Rhinitis, Allergic, Perennial; T-Lymphocytes; Terfenadine; Time Factors; Treatment Outcome | 2003 |
Accumulation of peribronchial mast cells in a mouse model of ovalbumin allergen induced chronic airway inflammation: modulation by immunostimulatory DNA sequences.
Topics: Adjuvants, Immunologic; Administration, Intranasal; Allergens; Animals; Bone Marrow Cells; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cell Aggregation; Cell Count; Cell Division; Chronic Disease; CpG Islands; Disease Models, Animal; DNA; DNA-Binding Proteins; Drug Administration Schedule; Female; Fluorescent Dyes; Growth Inhibitors; Immunoglobulin E; Inflammation; Injections, Subcutaneous; Interleukin-4; Interleukin-9; Lung; Mast Cells; Methacholine Chloride; Mice; Mice, Inbred BALB C; Oligodeoxyribonucleotides; Ovalbumin; Receptors, Cell Surface; Rhodamines; Toll-Like Receptor 9 | 2003 |
Recall helper T cell response: T helper 1 cell-resistant allergic susceptibility without biasing uncommitted CD4 T cells.
Topics: Animals; Antigens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; CD4 Antigens; CD4-Positive T-Lymphocytes; Disease Models, Animal; Eosinophils; Female; Flow Cytometry; Genetic Predisposition to Disease; Hypersensitivity, Immediate; Immune Tolerance; Inflammation; Methacholine Chloride; Mice; Mice, Inbred BALB C; Receptors, Interleukin-2; Th1 Cells; Th2 Cells | 2004 |
Site of inflammation influences site of hyperresponsiveness in experimental asthma.
Topics: Aerosols; Animals; Asthma; Bronchi; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Inflammation; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Function Tests; Respiratory Hypersensitivity; Time Factors; Vascular Resistance | 2003 |
Airway responsiveness after acute exposure to urban particulate matter 1648 in a DO11.10 murine model.
Topics: Air Pollutants; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Transgenic; Ovalbumin; Respiratory Hypersensitivity | 2004 |
Airway hyperresponsiveness to bradykinin induced by allergen challenge in actively sensitised Brown Norway rats.
Topics: Adenosine; Adrenergic beta-1 Receptor Agonists; Adrenergic beta-2 Receptor Antagonists; Animals; Arachidonate 5-Lipoxygenase; Bradykinin; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Endopeptidases; Lung; Male; Mast Cells; Methacholine Chloride; Ovalbumin; Rats; Rats, Inbred BN; Receptors, Muscarinic; Tachykinins | 2004 |
Adoptive transfer of alveolar macrophages abrogates bronchial hyperresponsiveness.
Topics: Adoptive Transfer; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Clodronic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Genetic Predisposition to Disease; Immunoglobulin E; Immunoglobulin G; Liposomes; Macrophages, Alveolar; Male; Methacholine Chloride; Ovalbumin; Rats; Rats, Sprague-Dawley; Reaction Time | 2004 |
Ozone-induced acute pulmonary injury in inbred mouse strains.
Topics: Acute Disease; Animals; Bronchoalveolar Lavage Fluid; Cell Division; Chemotaxis, Leukocyte; Chromosome Mapping; Disease Models, Animal; Drug Resistance; Genetic Predisposition to Disease; Interleukin-6; Lung; Lung Diseases; Lymphocytes; Male; Methacholine Chloride; Mice; Mice, Inbred Strains; Neutrophils; Ozone; Phenotype; Plethysmography; Respiratory Mucosa; Species Specificity | 2004 |
(S,S)-formoterol increases the production of IL-4 in mast cells and the airways of a murine asthma model.
Topics: Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Disease Models, Animal; Ethanolamines; Formoterol Fumarate; Histamine Release; Histocytochemistry; Humans; Interleukin-4; Jurkat Cells; Lung; Male; Mast Cells; Methacholine Chloride; Mice; Mice, Inbred BALB C; Prostaglandin D2; Stereoisomerism; T-Lymphocytes | 2004 |
Aerosolized anti-T-cell-receptor antibodies are effective against airway inflammation and hyperreactivity.
Topics: Administration, Inhalation; Airway Resistance; Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibody Specificity; Bronchial Hyperreactivity; Bronchitis; Disease Models, Animal; Dose-Response Relationship, Drug; Flow Cytometry; Lung; Lymphocyte Count; Lymphocyte Depletion; Methacholine Chloride; Mice; Mice, Inbred C57BL; Ovalbumin; Receptors, Antigen, T-Cell; Receptors, Antigen, T-Cell, gamma-delta; Respiratory Hypersensitivity; T-Lymphocyte Subsets | 2004 |
Increased tracheal responsiveness to beta-adrenergic agonist and antagonist in ovalbumin-sensitized guinea pigs.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aerosols; Animals; Bronchial Hyperreactivity; Disease Models, Animal; Guinea Pigs; Immunization; Injections, Intraperitoneal; Injections, Subcutaneous; Isoproterenol; Male; Methacholine Chloride; Ovalbumin; Propranolol; Trachea | 2004 |
Respiratory response to toluene diisocyanate depends on prior frequency and concentration of dermal sensitization in mice.
Topics: Administration, Intranasal; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Dermatitis, Allergic Contact; Disease Models, Animal; Immunoglobulin E; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Occupational Exposure; Plethysmography, Whole Body; Respiratory Mechanics; Toluene 2,4-Diisocyanate | 2004 |
Greater involvement of neurokinins found in Guinea pig models of severe asthma compared with mild asthma.
Topics: Administration, Inhalation; Airway Resistance; Allergens; Animals; Asthma; Biomarkers; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Capsaicin; Disease Models, Animal; Eosinophils; Guinea Pigs; Lung; Male; Methacholine Chloride; Neprilysin; Neurokinin A; Respiratory Hypersensitivity; Severity of Illness Index; Substance P | 2004 |
Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness.
Topics: Adoptive Transfer; Allergens; Alum Compounds; Analysis of Variance; Animals; Bronchial Hyperreactivity; Bronchitis; Bronchoalveolar Lavage Fluid; CD8 Antigens; CD8-Positive T-Lymphocytes; Cells, Cultured; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Interleukin-13; Lung; Methacholine Chloride; Mice; Mice, Mutant Strains; Ovalbumin; T-Lymphocyte Subsets | 2004 |
Involvement of enhanced neurokinin NK3 receptor expression in the severe asthma guinea pig model.
Topics: Animals; Asthma; Benzamides; Binding, Competitive; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Lung; Male; Methacholine Chloride; Neurokinin B; Ovalbumin; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Substance P; Tritium | 2004 |
Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma.
Topics: Animals; Asthma; B-Lymphocytes; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Complement C5a; Disease Models, Animal; Female; Haptens; Immunization; Immunoglobulin M; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Respiratory Function Tests; Respiratory System | 2004 |
The pattern of methacholine responsiveness in mice is dependent on antigen challenge dose.
Topics: Animals; Antigens; Bronchi; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Disease Models, Animal; Female; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin | 2004 |
Para-Bromophenacyl bromide alleviates airway hyperresponsiveness and modulates cytokines, IgE and eosinophil levels in ovalbumin-sensitized and -challenged mice.
Topics: Acetophenones; Administration, Inhalation; Aerosols; Airway Obstruction; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Eosinophils; Immunization; Immunoglobulin E; India; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phospholipases A | 2004 |
Effect of leptin on allergic airway responses in mice.
Topics: Administration, Cutaneous; Allergens; Animals; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Immunoglobulin E; Infusion Pumps, Implantable; Leptin; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Hypersensitivity; RNA, Messenger | 2005 |
A guinea pig model for cough variant asthma and role of tachykinins.
Topics: Airway Resistance; Allergens; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Cough; Disease Models, Animal; Guinea Pigs; Male; Methacholine Chloride; Ovalbumin; Peptides, Cyclic; Procaterol; Tachykinins | 2004 |
PPAR-gamma modulates allergic inflammation through up-regulation of PTEN.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Female; Gene Expression; Gene Expression Regulation; Interleukin-13; Interleukin-4; Interleukin-5; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phosphatidylinositol 3-Kinases; Phosphorylation; Pioglitazone; PPAR gamma; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; Rosiglitazone; Thiazolidinediones; Trachea; Transfection | 2005 |
Activation sequences following failed atrial defibrillation.
Topics: Animals; Atrial Fibrillation; Disease Models, Animal; Electric Countershock; Electrodes; Electrophysiologic Techniques, Cardiac; Female; Heart Atria; Male; Methacholine Chloride; Parasympathomimetics; Sheep | 2004 |
Antianginal effects of lercanidipine on the vasopressin or methacholine induced anginal model in rats.
Topics: Angina Pectoris; Animals; Dihydropyridines; Disease Models, Animal; Male; Methacholine Chloride; Rats; Rats, Sprague-Dawley; Vasodilator Agents; Vasopressins | 2005 |
Effect of salbutamol on pulmonary responsiveness in chronic pulmonary allergic inflammation in guinea pigs.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Asthma; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Guinea Pigs; Male; Methacholine Chloride; Ovalbumin; Time Factors | 2005 |
Effects of corticosteroid on the expression of thymus and activation-regulated chemokine in a murine model of allergic asthma.
Topics: Adrenal Cortex Hormones; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Count; Chemokine CCL17; Chemokines, CC; Dexamethasone; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Receptors, CCR4; Receptors, Chemokine; Receptors, CXCR3; Reverse Transcriptase Polymerase Chain Reaction; RNA | 2005 |
Interleukin-13-dependent bronchial hyper-responsiveness following isolated upper-airway allergen challenge in a murine model of allergic rhinitis and asthma.
Topics: Administration, Intranasal; Allergens; Animals; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Granulocytes; Humans; Immunoglobulin E; Immunoglobulin G; Interleukin-13; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Hypersensitivity | 2005 |
TNF-alpha induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A(2) activation.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytosol; Disease Models, Animal; Enzyme Activation; Histamine; Inflammation; Leukotriene B4; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Phospholipases A; Platelet Activating Factor; Pulmonary Eosinophilia; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2005 |
Exaggerated airway narrowing in mice treated with intratracheal cationic protein.
Topics: Administration, Inhalation; Animals; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Cations; Disease Models, Animal; Dose-Response Relationship, Drug; Intubation, Intratracheal; Methacholine Chloride; Mice; Mice, Inbred BALB C; Muscle, Smooth; Polylysine; Proteins; Respiratory Mucosa; Respiratory System; Time Factors | 2006 |
The PPARgamma ligand, rosiglitazone, reduces airways hyperresponsiveness in a murine model of allergen-induced inflammation.
Topics: Allergens; Animals; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Goblet Cells; Guinea Pigs; Hyperplasia; In Vitro Techniques; Injections, Intraperitoneal; Ligands; Matrix Metalloproteinase 2; Methacholine Chloride; Mice; Mice, Inbred C57BL; Muscle Contraction; Ovalbumin; Pneumonia; PPAR gamma; Respiratory Hypersensitivity; Rosiglitazone; Thiazolidinediones; Time Factors; Trachea; Vasodilator Agents | 2006 |
Effect of adenosine A2A receptor activation in murine models of respiratory disorders.
Topics: Aerosols; Allergens; Animals; Bronchoconstriction; Disease Models, Animal; Female; Leukocyte Count; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pulmonary Disease, Chronic Obstructive; Receptor, Adenosine A2A; Respiratory Function Tests | 2006 |
Intestinal ischemia/reperfusion induces bronchial hyperreactivity and increases serum TNF-alpha in rats.
Topics: Animals; Bronchial Hyperreactivity; Disease Models, Animal; Intestines; Liver; Male; Methacholine Chloride; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar; Reperfusion Injury; Tumor Necrosis Factor-alpha | 2006 |
Oxidant stress modulates murine allergic airway responses.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; F2-Isoprostanes; Female; Lipid Peroxidation; Lung; Macrophages, Alveolar; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Ovalbumin; Oxidative Stress; Specific Pathogen-Free Organisms; Spectrometry, Mass, Electrospray Ionization; Vitamin E; Vitamin E Deficiency | 2006 |
Respiratory syncytial virus infection in a murine model of cystic fibrosis.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Inflammation; Lung; Lymphocytes; Methacholine Chloride; Mice; Mice, Inbred CFTR; Neutrophils; Nitrates; Nitric Oxide; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses | 2006 |
Antigen sensitization modulates alveolar macrophage functions in an asthma model.
Topics: Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Clodronic Acid; Disease Models, Animal; Lung; Macrophages, Alveolar; Male; Methacholine Chloride; Ovalbumin; Rats; Rats, Inbred BN; Tumor Necrosis Factor-alpha | 2006 |
Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma.
Topics: Acetates; Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cyclopropanes; Disease Models, Animal; Female; Glucosides; Immunoglobulin E; Interleukin-13; Interleukin-4; Iridoid Glucosides; Iridoids; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Molecular Structure; Mucus; Ovalbumin; Plant Extracts; Pneumonia; Pulmonary Eosinophilia; Quinolines; Sulfides; Veronica | 2006 |
Histamine type 1 receptor deficiency reduces airway inflammation in a murine asthma model.
Topics: Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Histocytochemistry; Hypersensitivity; Immunoglobulin E; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovalbumin; Receptors, Histamine H1; Specific Pathogen-Free Organisms | 2006 |
Mast cells can promote the development of multiple features of chronic asthma in mice.
Topics: Animals; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Chronic Disease; Disease Models, Animal; Female; Humans; Hyperplasia; Mast Cells; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovalbumin; Proto-Oncogene Proteins c-kit; Receptors, IgG; Respiratory Mucosa | 2006 |
Effects of cryptoporus polysaccharide on rat allergic rhinitis associated with inhibiting eotaxin mRNA expression.
Topics: Airway Resistance; Animals; Anti-Allergic Agents; Bronchial Hyperreactivity; Bronchial Provocation Tests; Chemokine CCL11; Chemokines, CC; Chemotaxis, Leukocyte; Disease Models, Animal; Eosinophils; Fruiting Bodies, Fungal; Gene Expression Regulation; Lung; Lung Compliance; Methacholine Chloride; Nasal Mucosa; Ovalbumin; Polyporaceae; Polysaccharides; Rats; Rats, Sprague-Dawley; Rhinitis, Allergic, Seasonal; RNA, Messenger | 2006 |
Smooth muscle myosin isoform expression and LC20 phosphorylation in innate rat airway hyperresponsiveness.
Topics: Actins; Animals; Blotting, Western; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Calmodulin-Binding Proteins; Disease Models, Animal; Isomerism; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Myosin Heavy Chains; Myosin Light Chains; Phosphorylation; Rats; Rats, Inbred F344; Rats, Inbred Lew; Reverse Transcriptase Polymerase Chain Reaction; Smooth Muscle Myosins | 2006 |
Increased prostanoid dependency of arterial relaxation in Chlamydia pneumoniae-infected mice.
Topics: Animals; Aorta, Thoracic; Chlamydophila Infections; Chlamydophila pneumoniae; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Enzyme Inhibitors; Female; Methacholine Chloride; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Prostaglandins; Vasoconstrictor Agents; Vasodilation | 2006 |
CD38-deficient mice have reduced airway hyperresponsiveness following IL-13 challenge.
Topics: ADP-ribosyl Cyclase 1; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Interleukin-13; Kinetics; Membrane Glycoproteins; Methacholine Chloride; Mice; Mice, Knockout | 2006 |
Inhibition of mucin secretion with MARCKS-related peptide improves airway obstruction in a mouse model of asthma.
Topics: Airway Obstruction; Animals; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucins; Peptide Fragments | 2007 |
Effects of ciclamilast, a new PDE 4 PDE4 inhibitor, on airway hyperresponsiveness, PDE4D expression and airway inflammation in a murine model of asthma.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Allergens; Animals; Anti-Inflammatory Agents; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchitis; Bronchoalveolar Lavage Fluid; Chemokines; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Eosinophilia; Female; Gene Expression; Isoenzymes; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Phosphodiesterase Inhibitors; Pyridines; RNA, Messenger | 2006 |
Immunological determinants of ventilatory changes induced in mice by dermal sensitization and respiratory challenge with toluene diisocyanate.
Topics: Airway Resistance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Immunoglobulins; In Vitro Techniques; Lymphocytes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, SCID; Skin; Toluene 2,4-Diisocyanate | 2007 |
Intrinsic and antigen-induced airway hyperresponsiveness are the result of diverse physiological mechanisms.
Topics: Administration, Inhalation; Animals; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Computer Simulation; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intravenous; Mathematics; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Muscle Contraction; Muscle, Smooth; Phenotype; Respiratory Hypersensitivity | 2007 |
Differential effects of low and high dose folic acid on endothelial dysfunction in a murine model of mild hyperhomocysteinaemia.
Topics: Animals; Clotrimazole; Cystathionine beta-Synthase; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Folic Acid; Homocysteine; Hyperhomocysteinemia; Mesenteric Arteries; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Transgenic; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Vasodilation; Vasodilator Agents | 2006 |
Mouse genetic model for antigen-induced airway manifestations of asthma.
Topics: Animals; Antigens; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Disease Models, Animal; Immunoglobulin E; Male; Methacholine Chloride; Mice; Mice, Congenic; Mice, Inbred BALB C; Mice, Inbred Strains; Ovalbumin; Respiratory System; Species Specificity | 2007 |
Oral treatment with live Lactobacillus reuteri inhibits the allergic airway response in mice.
Topics: Administration, Oral; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; DNA, Bacterial; Eosinophils; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Limosilactobacillus reuteri; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Probiotics; Toll-Like Receptor 9; Tryptophan | 2007 |
Enhanced airway reactivity and inflammation in A2A adenosine receptor-deficient allergic mice.
Topics: Ambrosia; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cyclic AMP; Disease Models, Animal; I-kappa B Proteins; Leukocytes; Lipid Peroxidation; Male; Methacholine Chloride; Mice; Mice, Inbred Strains; Mice, Knockout; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Phosphorylation; Plethysmography, Whole Body; Pneumonia; Reactive Nitrogen Species; Receptor, Adenosine A2A; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor RelA; Tyrosine | 2007 |
Cessation of dexamethasone exacerbates airway responses to methacholine in asthmatic mice.
Topics: Administration, Oral; Airway Resistance; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Dexamethasone; Disease Models, Animal; Drug Administration Schedule; Eosinophils; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; Pulmonary Eosinophilia; Recurrence | 2007 |
Methacholine responsiveness in mice from 2 to 8 wk of age.
Topics: Aging; Animals; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Infusions, Intravenous; Lung; Lung Volume Measurements; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pregnancy; Respiratory Mechanics | 2007 |
Immunomodulatory effects of oak dust exposure in a murine model of allergic asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Chemokine CCL3; Chemokine CCL4; Chemokines, CC; Disease Models, Animal; Dust; Female; Inhalation Exposure; Interleukin-13; Leukocytes; Lung; Macrophage Inflammatory Proteins; Macrophages; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Ovalbumin; Quercus; RNA, Messenger; Tumor Necrosis Factor-alpha; Wood | 2007 |
Synergistic effect of formoterol and mometasone in a mouse model of allergic lung inflammation.
Topics: Administration, Intranasal; Adrenergic beta-Agonists; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Ethanolamines; Female; Formoterol Fumarate; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mometasone Furoate; Ovalbumin; Pregnadienediols; Respiratory Function Tests; Respiratory Hypersensitivity; Time Factors | 2007 |
Vasodilator effects of nebivolol in a rat model of hypertension and a rabbit model of congestive heart failure.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Disease Models, Animal; Endothelium, Vascular; Ethanolamines; Heart Failure; Hypertension; Male; Methacholine Chloride; Muscarinic Agonists; Nebivolol; Rabbits; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation; Vasodilator Agents | 2007 |
Suppression of the asthmatic phenotype by ultraviolet B-induced, antigen-specific regulatory cells.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Immunity, Cellular; Immunization; Immunoglobulin E; Lymph Nodes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phenotype; Rats; Rats, Sprague-Dawley; Ultraviolet Rays; Ultraviolet Therapy | 2007 |
Effect of TRFK-5 on airway responsiveness in ovalbumin-treated guinea pigs exposed to tobacco smoke.
Topics: Animals; Antibodies, Monoclonal; Bronchial Hyperreactivity; Capsaicin; Cell Movement; Disease Models, Animal; Eosinophils; Guinea Pigs; Histamine; Interleukin-5; Male; Methacholine Chloride; Ovalbumin; Tobacco Smoke Pollution | 2007 |
Methacholine-induced pulmonary gas trapping in a mouse model of allergic asthma: effect of inhaled budesonide and ciglitazone.
Topics: Administration, Inhalation; Airway Obstruction; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchodilator Agents; Budesonide; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; PPAR gamma; Thiazolidinediones | 2008 |
Effects of allergen on airway narrowing dynamics as assessed by lung-slice technique.
Topics: Airway Resistance; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Disease Models, Animal; Image Processing, Computer-Assisted; Methacholine Chloride; Mice; Mice, Inbred BALB C; Microscopy, Video; Muscle, Smooth; Ovalbumin | 2008 |
Impact of lung remodelling on respiratory mechanics in a model of severe allergic inflammation.
Topics: Animals; Asthma; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperplasia; Hypertrophy; Methacholine Chloride; Mice; Mice, Inbred BALB C; Microscopy, Electron; Muscarinic Agonists; Muscle, Smooth; Ovalbumin; Pulmonary Alveoli; Pulmonary Eosinophilia; Respiratory Hypersensitivity; Respiratory Mechanics | 2008 |
Estrogen determines sex differences in airway responsiveness after allergen exposure.
Topics: Allergens; Animals; Bronchial Hyperreactivity; Disease Models, Animal; Estradiol; Estrogen Receptor Modulators; Estrogens; Female; Fulvestrant; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neurokinin A; Neurokinin-1 Receptor Antagonists; Ovalbumin; Sex Characteristics | 2008 |
Pharmacological analysis of the interaction of antimuscarinic drugs at M(2) and M(3) muscarinic receptors in vivo using the pithed rat assay.
Topics: Animals; Blood Pressure; Bradycardia; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Infusions, Intravenous; Methacholine Chloride; Muscarinic Antagonists; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3 | 2008 |
Ovalbumin-sensitized mice are good models for airway hyperresponsiveness but not acute physiological responses to allergen inhalation.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Female; Humans; Immunoglobulin E; Immunoglobulin G; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Time Factors | 2008 |
Shortening of the induction period of allergic asthma in cynomolgus monkeys by Ascaris suum and house dust mite.
Topics: Administration, Inhalation; Administration, Oral; Airway Resistance; Allergens; Androstadienes; Animals; Anti-Asthmatic Agents; Antigens, Dermatophagoides; Ascaris suum; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cells, Cultured; Disease Models, Animal; Fluticasone; Helminth Proteins; Immunoglobulin E; Injections, Intramuscular; Injections, Intraperitoneal; Interleukin-4; Interleukin-5; Intradermal Tests; Leukocytes, Mononuclear; Macaca fascicularis; Male; Methacholine Chloride; Prednisolone; Receptors, CCR4; T-Lymphocytes, Helper-Inducer; Time Factors | 2008 |
Ym1 and Ym2 expression in a mouse model exposed to diesel exhaust particles.
Topics: Air Pollutants; Animals; Asthma; beta-N-Acetylhexosaminidases; Bronchoalveolar Lavage Fluid; Chitinases; Disease Models, Animal; Environmental Monitoring; Female; Gasoline; Gene Expression; Inhalation Exposure; Interleukin-4; Lectins; Methacholine Chloride; Mice; Mice, Inbred BALB C; Particle Size; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Specific Pathogen-Free Organisms; Vehicle Emissions | 2008 |
Acute salivary gland hypofunction in the duct ligation model in the absence of inflammation.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Dexamethasone; Disease Models, Animal; Glucocorticoids; Ligation; Macrophages; Methacholine Chloride; Neutrophils; Parasympathomimetics; Peroxidase; Potentiometry; Rats; Rats, Wistar; Saliva; Salivary Ducts; Salivary Proteins and Peptides; Secretory Rate; Sialadenitis; Submandibular Gland; Submandibular Gland Diseases; Time Factors; Xerostomia | 2008 |
Cholinergic nitric oxide release from the urinary bladder mucosa in cyclophosphamide-induced cystitis of the anaesthetized rat.
Topics: Animals; Cyclophosphamide; Cystitis; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Methacholine Chloride; Mucous Membrane; Muscarinic Agonists; Muscarinic Antagonists; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M3; Receptor, Muscarinic M5; Urinary Bladder; Urothelium | 2008 |
Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation.
Topics: Airway Resistance; Animals; Body Weight; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Inflammation Mediators; Injections, Intravenous; Lung Compliance; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Obesity; Ozone; Phenotype; Pneumonia; Pulmonary Edema; Respiratory Mechanics | 2008 |
Establishing the phenotype in novel acute and chronic murine models of allergic asthma.
Topics: Acute Disease; Administration, Inhalation; Allergens; Animals; Antibodies; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cell Count; Chronic Disease; Disease Models, Animal; Hypersensitivity; Immunoglobulin E; Immunoglobulin G; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phenotype; Plethysmography, Whole Body; Pneumonia; Respiratory Function Tests | 2008 |
Computational assessment of airway wall stiffness in vivo in allergically inflamed mouse models of asthma.
Topics: Airway Resistance; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Computer Simulation; Disease Models, Animal; Elasticity; Female; Inflammation; Injections, Intravenous; Methacholine Chloride; Mice; Mice, Inbred BALB C; Models, Biological; Ovalbumin; Time Factors | 2008 |
Animal models of airway sensitization.
Topics: Airway Resistance; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cell Count; Cell Proliferation; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunity, Cellular; Immunization; Lung Compliance; Methacholine Chloride; Mice; Ovalbumin; Plethysmography, Whole Body | 2007 |
Mepacrine alleviates airway hyperresponsiveness and airway inflammation in a mouse model of asthma.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cysteine; Cytokines; Disease Models, Animal; Eosinophils; Immunoglobulin E; Inflammation; Leukotrienes; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phospholipases A2, Secretory; Quinacrine | 2008 |
Attenuated methacholine airway response following repeat testing in a murine model of allergic airways disease.
Topics: Animals; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Female; Inflammation; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin | 2008 |
Basenji-greyhound dog model of asthma: pulmonary responses after beta-adrenergic blockade.
Topics: Adrenergic beta-Antagonists; Aerosols; Airway Resistance; Animals; Asthma; Citrates; Citric Acid; Disease Models, Animal; Dogs; Heart Rate; Lung Compliance; Methacholine Chloride; Methacholine Compounds; Respiration | 1981 |
[The abnormal ECG and the appearance of methacholine-induced arrhythmias in SART mice and effects of beta-blockers, oxprenolol, propranolol, and carteolol].
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System Diseases; Carteolol; Disease Models, Animal; Electrocardiography; Male; Methacholine Chloride; Methacholine Compounds; Mice; Oxprenolol; Propanolamines; Propranolol | 1984 |
Parainfluenza virus type-3 infection attenuates the respiratory effects of antigen challenge in sensitized guinea pigs.
Topics: Aerosols; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Dyspnea; Eosinophils; Guinea Pigs; Histamine Release; In Vitro Techniques; Male; Methacholine Chloride; Ovalbumin; Parainfluenza Virus 3, Human; Paramyxoviridae Infections | 1995 |
Involvement of thromboxane A2 in propranolol-induced bronchoconstriction after allergic bronchoconstriction in guinea pigs.
Topics: Administration, Inhalation; Analysis of Variance; Animals; Asthma; Bridged Bicyclo Compounds; Bronchial Provocation Tests; Constriction, Pathologic; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Guinea Pigs; Hypersensitivity; Inflammation; Injections, Intravenous; Male; Methacholine Chloride; Premedication; Propranolol; Receptors, Prostaglandin; Thromboxane A2; Time Factors | 1994 |
[Nonspecific inhalative provocation in the sheep as an asthma model--correlation of respiratory and cardiovascular effects].
Topics: Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Carbon Dioxide; Disease Models, Animal; Dose-Response Relationship, Drug; Lung Volume Measurements; Methacholine Chloride; Oxygen; Pulmonary Wedge Pressure; Sheep; Ventilation-Perfusion Ratio | 1994 |
Virus-induced airway inflammation and hyperresponsiveness in the guinea-pig is inhibited by levodropropizine.
Topics: Animals; Antitussive Agents; Bronchial Hyperreactivity; Bronchitis; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Guinea Pigs; Histamine; Leukocytes; Male; Methacholine Chloride; Parainfluenza Virus 3, Human; Paramyxoviridae Infections; Premedication; Propylene Glycols; Specific Pathogen-Free Organisms | 1993 |
Effect of KRN2391, a novel vasodilator, on various experimental anginal models in rats.
Topics: Angina Pectoris; Animals; Disease Models, Animal; Electrocardiography; Injections, Intravenous; Isoproterenol; Male; Methacholine Chloride; Niacinamide; Nicorandil; Nifedipine; Pyridines; Rats; Rats, Wistar; Vasodilator Agents | 1993 |
Endothelium dependent relaxation in two different models of chronic heart failure and the effect of ibopamine.
Topics: Animals; Aortic Valve Stenosis; Culture Techniques; Deoxyepinephrine; Disease Models, Animal; Endothelium, Vascular; Epinephrine; Heart Failure; Male; Methacholine Chloride; Myocardial Infarction; Norepinephrine; Phenylephrine; Rats; Rats, Wistar; Vasodilator Agents | 1993 |
Impaired beta-adrenergic receptor activation of adenylyl cyclase in airway smooth muscle in the basenji-greyhound dog model of airway hyperresponsiveness.
Topics: Adenylyl Cyclases; Analysis of Variance; Animals; Bronchial Hyperreactivity; Bucladesine; Cholera Toxin; Colforsin; Dinoprostone; Disease Models, Animal; Dogs; Enzyme Activation; Immunoblotting; Isoproterenol; Lung; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Radioimmunoassay; Receptors, Adrenergic, beta; Trachea | 1993 |
Effect of FK409, a novel nitric oxide donor, on acute experimental myocardial ischemia.
Topics: Animals; Coronary Circulation; Coronary Vessels; Dipyridamole; Disease Models, Animal; Dogs; Electric Stimulation; Electrocardiography; Female; In Vitro Techniques; Male; Methacholine Chloride; Myocardial Ischemia; Nitric Oxide; Nitro Compounds; Nitroglycerin; Rats; Vasodilation; Vasodilator Agents | 1993 |
Effects of a thromboxane synthase inhibitor (CS-518) on the eosinophil-dependent late asthmatic response and airway hyperresponsiveness in guinea pigs.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Chemotaxis, Leukocyte; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eosinophils; Guinea Pigs; Male; Methacholine Chloride; Ovalbumin; Pulmonary Eosinophilia; Thiophenes; Thromboxane-A Synthase | 1996 |
Relationship between airway eosinophilia and airway hyperresponsiveness in a late asthmatic model of guinea pigs.
Topics: Animals; Antibodies; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Eosinophils; Guinea Pigs; Histamine; Interleukin-5; Leukocyte Count; Leukotriene C4; Male; Methacholine Chloride; Ovalbumin; Passive Cutaneous Anaphylaxis; Pulmonary Eosinophilia; Thromboxane B2; Time Factors | 1996 |
Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.
Topics: Aerosols; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophilia; Interleukin-5; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Ovalbumin; Respiratory System | 1996 |
Methacholine-induced histamine liberation during airway challenge tests in Ascaris skin-sensitive sheep.
Topics: Aerosols; Airway Obstruction; Airway Resistance; Allergens; Animals; Ascaris; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Dermatitis, Allergic Contact; Disease Models, Animal; Elasticity; Electric Stimulation; Histamine; Histamine Release; Inhalation; Intubation, Intratracheal; Methacholine Chloride; Pressure; Reproducibility of Results; Respiratory Mechanics; Respiratory Muscles; Sheep; Vagotomy; Vagus Nerve | 1995 |
The effects of three models of airway disease on tidal breathing flow-volume loops of thoroughbred horses.
Topics: Administration, Inhalation; Aerosols; Airway Resistance; Animals; Bronchoconstrictor Agents; Disease Models, Animal; Expiratory Reserve Volume; Female; Histamine; Horse Diseases; Horses; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Random Allocation; Respiratory System; Respiratory Tract Diseases; Tidal Volume | 1995 |
Characterization of a primate model of asthma using anti-allergy/anti-asthma agents.
Topics: Albuterol; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Antigens; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Cetirizine; Dexamethasone; Disease Models, Animal; Leukocytes; Macaca fascicularis; Male; Methacholine Chloride; Pyrilamine; Salmeterol Xinafoate | 1996 |
The importance of leukotrienes in airway inflammation in a mouse model of asthma.
Topics: 5-Lipoxygenase-Activating Proteins; Allergens; Animals; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Carrier Proteins; Disease Models, Animal; Female; Immunoglobulin E; Inflammation; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Membrane Proteins; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucus; Ovalbumin; Pulmonary Eosinophilia; Respiratory Function Tests; Respiratory System | 1996 |
Inhibition of T cell costimulation abrogates airway hyperresponsiveness in a murine model.
Topics: Airway Resistance; Animals; Bronchoalveolar Lavage; Bronchoconstrictor Agents; CD28 Antigens; Cell Division; Disease Models, Animal; Flow Cytometry; Histocytochemistry; Hypersensitivity; Immunoglobulin E; Immunoglobulin G; Immunohistochemistry; Inflammation; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; T-Lymphocytes | 1996 |
Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction.
Topics: Airway Obstruction; Airway Resistance; Animals; Blotting, Northern; Blotting, Southern; Cloning, Molecular; Disease Models, Animal; Gene Expression Regulation; Histocytochemistry; Immunohistochemistry; Interleukin-11; Lung; Methacholine Chloride; Mice; Mice, Transgenic; Microscopy, Electron; Promoter Regions, Genetic; Proteins; Pulmonary Fibrosis; Uteroglobin | 1996 |
Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration.
Topics: Administration, Inhalation; Aerosols; Animals; Antibodies, Monoclonal; Antigens; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophil Peroxidase; Eosinophils; Interferon-gamma; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Peroxidases | 1997 |
Tracheal gas insufflation improves ventilatory efficiency during metacholine-induced bronchospasm.
Topics: Animals; Bronchial Spasm; Bronchoconstrictor Agents; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Hemodynamics; Insufflation; Methacholine Chloride; Oxygen Inhalation Therapy; Pulmonary Gas Exchange; Respiration, Artificial; Trachea | 1997 |
Airway hyperresponsiveness in a rat model of chronic bronchitis: role of C fibers.
Topics: Animals; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Bronchoconstrictor Agents; Capsaicin; Disease Models, Animal; Female; Methacholine Chloride; Nerve Fibers; Rats; Rats, Sprague-Dawley; Respiratory Mechanics; Sulfur Dioxide; Trachea | 1997 |
Murine CTLA4-IgG treatment inhibits airway eosinophilia and hyperresponsiveness and attenuates IgE upregulation in a murine model of allergic asthma.
Topics: Abatacept; Administration, Inhalation; Animals; Antigens, CD; Antigens, Differentiation; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoconstrictor Agents; CTLA-4 Antigen; Cytokines; Disease Models, Animal; Eosinophilia; Immunoconjugates; Immunoglobulin E; Immunoglobulin G; Immunosuppressive Agents; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Protein Binding; Pulmonary Alveoli; Specific Pathogen-Free Organisms; Spleen; Up-Regulation | 1997 |
Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography.
Topics: Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Disease Models, Animal; Female; Humans; Hypersensitivity; Methacholine Chloride; Mice; Mice, Inbred BALB C; Plethysmography, Whole Body; Reproducibility of Results | 1997 |
Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma.
Topics: Allergens; Animals; Antibodies, Monoclonal; Antigens, CD; Asthma; Bronchoconstrictor Agents; Cell Movement; Disease Models, Animal; Eosinophils; Female; Humans; Integrin alpha4; Leukocytes; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Hypersensitivity; Th2 Cells | 1997 |
Respiratory syncytial virus affects pulmonary function in BALB/c mice.
Topics: Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cells, Cultured; Disease Models, Animal; Leukocyte Count; Lymphocyte Count; Lymphocytes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Plethysmography, Whole Body; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Weight Loss | 1998 |
Partitioning of alterations in pulmonary mechanics due to vascular engorgement in piglets.
Topics: Airway Resistance; Analysis of Variance; Animals; Animals, Newborn; Blood Volume; Bronchial Provocation Tests; Catheterization; Disease Models, Animal; Methacholine Chloride; Pulmonary Circulation; Reference Values; Respiratory Mechanics | 1998 |
CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma.
Topics: Abatacept; Airway Resistance; Animals; Antibodies, Helminth; Antigens, CD; Antigens, Differentiation; Antigens, Helminth; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; CTLA-4 Antigen; Culture Media, Conditioned; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophilia; Female; Humans; Immunoconjugates; Immunoglobulin E; Immunosuppressive Agents; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Recombinant Fusion Proteins; Schistosoma mansoni; T-Lymphocytes; Th1 Cells; Th2 Cells | 1998 |
Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice.
Topics: Administration, Cutaneous; Aerosols; Allergens; Animals; Antibody Specificity; Asthma; Base Sequence; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Dermatitis, Atopic; Disease Models, Animal; DNA Primers; Eosinophilia; Female; Immunization; Immunoglobulin E; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; RNA, Messenger; Skin | 1998 |
Repeated measurements of airway and parenchymal mechanics in rats by using low-frequency oscillations.
Topics: Aerosols; Airway Resistance; Animals; Disease Models, Animal; Hypersensitivity; Lung; Male; Methacholine Chloride; Rats; Respiratory Mechanics; Thorax | 1998 |
Allergen immunotherapy inhibits airway eosinophilia and hyperresponsiveness associated with decreased IL-4 production by lymphocytes in a murine model of allergic asthma.
Topics: Alveolitis, Extrinsic Allergic; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Desensitization, Immunologic; Disease Models, Animal; Immunoglobulin E; Immunoglobulin G; Interferon-gamma; Interleukin-4; Lymph Nodes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Pulmonary Eosinophilia; Specific Pathogen-Free Organisms; T-Lymphocytes | 1998 |
Inhalation anaesthetics produce asynchronous reversal of ventilation inhomogeneity and increased lung resistance in a canine model of bronchial asthma.
Topics: Airway Resistance; Anesthetics, Inhalation; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Methacholine Chloride; Respiratory Mechanics | 1998 |
Differential effects of endogenous and exogenous interferon-gamma on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma.
Topics: Administration, Inhalation; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II; Hypersensitivity; Immunoglobulin E; Injections, Intraperitoneal; Interferon-gamma; Leukocytes; Lymph Nodes; Macrophages, Alveolar; Methacholine Chloride; Mice; Mice, Knockout; Ovalbumin; Spleen; T-Lymphocytes | 1998 |
Both CD80 and CD86 co-stimulatory molecules regulate allergic pulmonary inflammation.
Topics: Animals; Antigens, CD; Asthma; B7-1 Antigen; B7-2 Antigen; Bronchial Hyperreactivity; Cytokines; Disease Models, Animal; Eosinophilia; Lung; Lymphocyte Activation; Male; Membrane Glycoproteins; Methacholine Chloride; Mice; Mice, Inbred BALB C; Respiratory Hypersensitivity; T-Lymphocytes; Th2 Cells | 1998 |
Effects of endogenous superoxide anion and nitric oxide on cholinergic constriction of normal and hyperreactive guinea pig airways.
Topics: Administration, Inhalation; Aerosols; Allergens; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bronchodilator Agents; Cholinergic Fibers; Disease Models, Animal; Enzyme Inhibitors; Free Radical Scavengers; Guinea Pigs; Immunization; Methacholine Chloride; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ovalbumin; Parasympathomimetics; Superoxide Dismutase; Superoxides; Trachea | 1998 |
Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice.
Topics: Adjuvants, Immunologic; Administration, Intranasal; Allergens; Animals; Anti-Inflammatory Agents; Bone Marrow; Bronchial Hyperreactivity; Bronchial Provocation Tests; CpG Islands; Desensitization, Immunologic; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Eosinophils; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Hypereosinophilic Syndrome; Interferon-gamma; Interleukin-3; Interleukin-5; Methacholine Chloride; Mice; Mice, Inbred BALB C; Oligodeoxyribonucleotides; Ovalbumin; Plethysmography, Whole Body; Pulmonary Eosinophilia; Th2 Cells; Trachea | 1998 |
Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Cytokines; Disease Models, Animal; Eosinophils; Histocytochemistry; Hypersensitivity; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, SCID; Mice, Transgenic; Ovalbumin; Th1 Cells; Th2 Cells | 1999 |
A murine model of latex allergy-induced airway hyperreactivity.
Topics: Airway Resistance; Animals; Antibody Specificity; Bronchial Hyperreactivity; Disease Models, Animal; Eosinophils; Immunoglobulin E; Immunoglobulin G; Injections, Intraperitoneal; Latex; Latex Hypersensitivity; Methacholine Chloride; Mice; Mice, Inbred BALB C; Respiratory Mechanics | 1999 |
An in vivo model of beta-adrenoceptor desensitization.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Albuterol; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Guinea Pigs; Interleukin-1; Intubation, Intratracheal; Isoproterenol; Male; Methacholine Chloride; Respiratory Hypersensitivity | 1998 |
An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen.
Topics: Aerosols; Allergens; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Eosinophils; Epithelium; Female; Immunoglobulin E; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Specific Pathogen-Free Organisms; Trachea | 1998 |
Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Calcium; Disease Models, Animal; Gene Targeting; Histocytochemistry; Humans; Isoenzymes; Lung; Methacholine Chloride; Mice; Mice, Knockout; Nitric Oxide Synthase; Ovalbumin; Plethysmography; Pneumonia | 1999 |
Dissociation of airway hyperresponsiveness from immunoglobulin E and airway eosinophilia in a murine model of allergic asthma.
Topics: Animals; Asthma; Bronchoconstrictor Agents; Cell Movement; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophilia; Humans; Immunoglobulin E; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ovalbumin; Respiratory Hypersensitivity | 1999 |
Shifts in lung lymphocyte profiles correlate with the sequential development of acute allergic and chronic tolerant stages in a murine asthma model.
Topics: Airway Resistance; Animals; Asthma; B-Lymphocytes; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fluorescent Antibody Technique; Hypersensitivity; Immunoglobulin E; Lymphocytes; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Ovalbumin; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes; Time Factors | 1999 |
Can early timed internal atrial defibrillation shocks reduce the atrial defibrillation threshold?
Topics: Animals; Atrial Fibrillation; Defibrillators, Implantable; Disease Models, Animal; Electric Countershock; Electrocardiography; Female; Heart Atria; Heart Rate; Infusions, Intravenous; Male; Maximum Allowable Concentration; Methacholine Chloride; Parasympathomimetics; Reproducibility of Results; Sheep; Time Factors | 1999 |
Allergen-induced increase in airway responsiveness, airway eosinophilia, and bone-marrow eosinophil progenitors in mice.
Topics: Allergens; Animals; Asthma; Bone Marrow; Bronchial Hyperreactivity; Colony-Forming Units Assay; Disease Models, Animal; Dogs; Eosinophilia; Eosinophils; Hematopoiesis; Hematopoietic Stem Cells; Humans; Interleukin-5; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin | 1999 |
Critical role of CD23 in allergen-induced bronchoconstriction in a murine model of allergic asthma.
Topics: Allergens; Animals; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Eosinophils; Female; Immunoglobulin E; Macrophages, Alveolar; Methacholine Chloride; Mice; Mice, Congenic; Mice, Inbred BALB C; Mice, Inbred C57BL; Ovalbumin; Receptors, Fc; Receptors, IgE; Time Factors | 1999 |
Induction of atrial fibrillation and flutter in dogs using methacholine.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Atrial Fibrillation; Atrial Flutter; Cardiac Pacing, Artificial; Disease Models, Animal; Dogs; Forecasting; Halothane; Methacholine Chloride; Propofol; Refractory Period, Electrophysiological | 1999 |
In vivo airway eosinophil accumulation does not enhance antigen- or propranolol-induced bronchoconstriction in guinea pigs.
Topics: Administration, Inhalation; Administration, Intranasal; Animals; Antigens; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Eosinophils; Guinea Pigs; Lipids; Male; Methacholine Chloride; Mice; Polymyxin B; Propranolol; Respiratory System | 1999 |
Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthma.
Topics: Administration, Intranasal; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Movement; Disease Models, Animal; Eosinophils; Female; Humans; Immunoglobulin E; Injections, Intraperitoneal; Leukocytes, Mononuclear; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucus; Ovalbumin; Receptors, Interleukin-4; Solubility | 2000 |
Nasal hyperresponsiveness to histamine induced by repetitive exposure to cedar pollen in guinea-pigs.
Topics: Administration, Inhalation; Airway Resistance; Allergens; Animals; Atropine; Disease Models, Animal; Guinea Pigs; Histamine; Immunization; Male; Methacholine Chloride; Naphazoline; Nasal Cavity; Pollen; Pyrilamine; Reference Values; Respiratory Hypersensitivity; Rhinitis, Allergic, Perennial; Sensitivity and Specificity; Trees | 1999 |
Sequential development of airway hyperresponsiveness and acute airway obstruction in a mouse model of allergic inflammation.
Topics: Airway Obstruction; Airway Resistance; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Immunoglobulin E; Immunoglobulin G; Maximal Expiratory Flow Rate; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Plethysmography, Whole Body; Tidal Volume | 2000 |
Effect of suplatast tosilate (IPD-1151T) on a mouse model of asthma: inhibition of eosinophilic inflammation and bronchial hyperresponsiveness.
Topics: Animals; Anti-Allergic Agents; Arylsulfonates; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Eosinophilia; Female; Immunoglobulin E; Immunoglobulin G; Lung; Methacholine Chloride; Mice; Ovalbumin; Sulfonium Compounds | 2000 |
Recombinant human platelet-activating factor-acetylhydrolase inhibits airway inflammation and hyperreactivity in mouse asthma model.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Movement; Disease Models, Animal; Eosinophils; Female; Humans; Interleukin-5; Lung; Macrophages; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucus; Phospholipases A; Platelet Activating Factor; Recombinant Proteins | 2000 |
Differential effects of nitric oxide synthase inhibitors in an in vivo allergic rat model.
Topics: Animals; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Citrulline; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Hypersensitivity; Male; Methacholine Chloride; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Thiourea | 2000 |
Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice.
Topics: Allergens; Animals; Asthma; Disease Models, Animal; Mast Cells; Methacholine Chloride; Mice; Ovalbumin; Respiratory Hypersensitivity; Sodium Chloride | 2000 |
Differences in time-related cardiopulmonary responses to hypoxia in three rat strains.
Topics: Altitude; Animals; Carbachol; Disease Models, Animal; Endothelin-1; Endothelins; Hypertension, Pulmonary; Hypertrophy; Hypertrophy, Right Ventricular; Hypoxia; In Vitro Techniques; Male; Methacholine Chloride; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Rats, Wistar; Species Specificity; Trachea; Vasoconstriction; Vasodilation | 2000 |
Respiratory syncytial virus (RSV)-induced airway hyperresponsiveness in allergically sensitized mice is inhibited by live RSV and exacerbated by formalin-inactivated RSV.
Topics: Administration, Intranasal; Animals; Disease Models, Animal; Female; Formaldehyde; Methacholine Chloride; Mice; Mice, Inbred BALB C; Respiratory Hypersensitivity; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Vaccines, Inactivated; Viral Vaccines | 2000 |
Mucosal IL-12 inhibits airway reactivity to methacholine and respiratory failure in murine asthma.
Topics: Adjuvants, Immunologic; Allergens; Asthma; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Interleukin-12; Intubation, Intratracheal; Methacholine Chloride; Pollen; Respiratory Insufficiency; Respiratory Mucosa | 2000 |
Time course of inflammatory and remodeling events in a murine model of asthma: effect of steroid treatment.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cell Division; Dexamethasone; Disease Models, Animal; Eosinophils; Epithelial Cells; Fibronectins; Immunoglobulin E; Interleukin-4; Interleukin-5; Leukocyte Count; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mucus; Ovalbumin; Plasma; Pulmonary Alveoli; Respiratory Mucosa; Species Specificity; Time Factors | 2000 |
Endotoxin responsiveness and subchronic grain dust-induced airway disease.
Topics: Actins; Acute Disease; Administration, Inhalation; Aerosols; Airway Resistance; Animals; Bronchoalveolar Lavage Fluid; Collagen; Crosses, Genetic; Disease Models, Animal; Dust; Endotoxins; Genetic Predisposition to Disease; Immunohistochemistry; Lung Diseases, Obstructive; Methacholine Chloride; Mice; Mice, Inbred C3H; Neutrophils; Pneumonia; Species Specificity; Zea mays | 2001 |
Inhibition of eosinophilic inflammation in allergen-challenged TNF receptor p55/p75--and TNF receptor p55-deficient mice.
Topics: Allergens; Animals; Antigens, CD; Bronchoalveolar Lavage Fluid; Cell Adhesion; Disease Models, Animal; Endothelium, Vascular; Eosinophils; Inflammation; Interleukin-5; Lung; Methacholine Chloride; Mice; Mice, Knockout; Mice, Transgenic; Microcirculation; Ovalbumin; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Splanchnic Circulation; Tumor Necrosis Factor-alpha | 2001 |
Enhanced airway Th2 response after allergen challenge in mice deficient in CC chemokine receptor-2 (CCR2).
Topics: Administration, Inhalation; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Chemokine CCL2; Disease Models, Animal; Eosinophilia; Immunoglobulin E; Immunoglobulin G; Injections, Intraperitoneal; Lung; Lymphocyte Activation; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Ovalbumin; Receptors, CCR2; Receptors, Chemokine; Th2 Cells | 2001 |
Effects of BCG on ovalbumin-induced bronchial hyperreactivity in a guinea pig asthma model.
Topics: Animals; Asthma; BCG Vaccine; Biopsy; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Disease Models, Animal; Flow Cytometry; Guinea Pigs; Immunoglobulin G; Immunohistochemistry; Lung; Lymphocyte Subsets; Male; Methacholine Chloride; Nebulizers and Vaporizers; Ovalbumin; Skin; Time Factors | 2001 |
Airway inflammation and bronchial hyperresponsiveness after Mycoplasma pneumoniae infection in a murine model.
Topics: Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation; Interferon-gamma; Leukocyte Count; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mycoplasma pneumoniae; Pneumonia, Mycoplasma; RNA, Messenger | 2001 |
L-Selectin is required for the development of airway hyperresponsiveness but not airway inflammation in a murine model of asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Flow Cytometry; Humans; Immunoglobulin E; Inflammation; L-Selectin; Leukocyte Count; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Ovalbumin | 2001 |
Comparison of the anti-bronchoconstrictor activities of inhaled formoterol, its (R,R)- and (S,S)-enantiomers and salmeterol in the rhesus monkey.
Topics: Administration, Inhalation; Airway Resistance; Albuterol; Animals; Bronchial Spasm; Bronchoconstrictor Agents; Bronchodilator Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanolamines; Formoterol Fumarate; Macaca mulatta; Male; Methacholine Chloride; Salmeterol Xinafoate; Tachycardia | 2001 |
Tumor necrosis factor receptor 2 contributes to ozone-induced airway hyperresponsiveness in mice.
Topics: Administration, Inhalation; Animals; Animals, Wild; Antigens, CD; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Environmental Exposure; Leukocyte Count; Methacholine Chloride; Mice; Mice, Knockout; Neutrophils; Oxidants, Photochemical; Ozone; Plethysmography, Whole Body; Pulmonary Ventilation; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Time Factors | 2001 |
CTLA4-IgG reverses asthma manifestations in a mild but not in a more "severe" ongoing murine model.
Topics: Abatacept; Aerosols; Allergens; Aluminum Hydroxide; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Antigens, CD; Antigens, Differentiation; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cells, Cultured; CTLA-4 Antigen; Cytokines; Dexamethasone; Disease Models, Animal; Emulsions; Eosinophils; Immunization; Immunoconjugates; Immunoglobulin E; Immunosuppressive Agents; Interleukin-5; Leukocyte Count; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nasal Provocation Tests; Ovalbumin; Specific Pathogen-Free Organisms; T-Lymphocyte Subsets | 2001 |
Construction of single-chain interleukin-12 DNA plasmid to treat airway hyperresponsiveness in an animal model of asthma.
Topics: Allergens; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; COS Cells; Disease Models, Animal; Female; Genetic Therapy; Immunotherapy; Inflammation; Interleukin-12; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Plasmids; Transfection; Vaccines, DNA | 2001 |
Airway hyperresponsiveness in transgenic mice overexpressing platelet activating factor receptor is mediated by an atropine-sensitive pathway.
Topics: Animals; Atropine; Bronchial Diseases; Bronchoconstrictor Agents; Bronchodilator Agents; Disease Models, Animal; Free Radical Scavengers; Methacholine Chloride; Mice; Mice, Transgenic; Muscle, Smooth; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Muscarinic; Respiratory System; Serotonin; Signal Transduction | 2002 |
CXCR2 is necessary for the development and persistence of chronic fungal asthma in mice.
Topics: Animals; Aspergillus fumigatus; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Movement; Chemokine CCL11; Chemokine CCL4; Chemokine CCL5; Chemokine CXCL10; Chemokines, CC; Chemokines, CXC; Chronic Disease; Disease Models, Animal; Eosinophils; Female; Immunity, Innate; Immunoglobulin E; Interferon-gamma; Interleukin-12; Interleukin-4; Interleukin-5; Lung; Macrophage Inflammatory Proteins; Methacholine Chloride; Mice; Mice, Knockout; Neutrophils; Peroxidase; Receptors, Interleukin-8B; Spores, Fungal; T-Lymphocytes | 2002 |
CD4(+) T-lymphocytes regulate airway remodeling and hyper-reactivity in a mouse model of chronic asthma.
Topics: Allergens; Animals; Antibodies, Monoclonal; Asthma; Bronchi; Bronchial Hyperreactivity; CD4-Positive T-Lymphocytes; Chronic Disease; Disease Models, Animal; Female; Image Processing, Computer-Assisted; Immunization; Immunoglobulin G; Immunohistochemistry; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Specific Pathogen-Free Organisms | 2002 |
Nonlinearity of respiratory mechanics during bronchoconstriction in mice with airway inflammation.
Topics: Administration, Inhalation; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cell Count; Disease Models, Animal; Female; Lung Volume Measurements; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nonlinear Dynamics; Ovalbumin; Pneumonia; Positive-Pressure Respiration; Respiration, Artificial; Respiratory Mechanics | 2002 |
Relationship between density of muscarinic receptors and nasal hypersecretion in a nasal allergic model.
Topics: Animals; Autonomic Nervous System; Disease Models, Animal; Guinea Pigs; Immunoglobulin E; Immunoglobulin G; Male; Methacholine Chloride; Nasal Mucosa; Nasal Provocation Tests; Ovalbumin; Parasympathetic Nervous System; Quinuclidinyl Benzilate; Receptors, Muscarinic; Respiratory Hypersensitivity; Tritium | 1992 |
Hyperoxia-induced airway hyperresponsiveness and remodeling in immature rats.
Topics: Aerosols; Animals; Bronchi; Bronchial Hyperreactivity; Disease Models, Animal; Epithelium; Methacholine Chloride; Muscle, Smooth; Oxygen; Rats; Rats, Inbred Strains | 1992 |
[The mechanism of airway hyperresponsiveness following immediate bronchial response in ovalbumin (OA)-sensitized guinea pigs].
Topics: Animals; Asthma; Bronchi; Bronchoconstriction; Disease Models, Animal; Guinea Pigs; Male; Methacholine Chloride; Ovalbumin; Receptors, Adrenergic, beta | 1991 |
Nasal mucosal hypersensitivity in guinea pigs intermittently exposed to cold.
Topics: Animals; Cold Temperature; Disease Models, Animal; Guinea Pigs; Histamine; Immune Sera; Male; Methacholine Chloride; Nasal Mucosa; Nasal Provocation Tests; Ovalbumin; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Histamine H1; Receptors, Muscarinic; Respiratory Hypersensitivity; Stress, Physiological | 1991 |
Viral bronchiolitis during early life induces increased numbers of bronchiolar mast cells and airway hyperresponsiveness.
Topics: Animals; Bronchiolitis; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Eosinophils; Immunization; Mast Cells; Methacholine Chloride; Microscopy, Electron; Neutrophils; Ovalbumin; Parainfluenza Virus 1, Human; Paramyxoviridae Infections; Rats; Respiratory System; Staining and Labeling | 1990 |
Increased metachromatic cells and lymphocytes in bronchoalveolar lavage fluid of dogs with airway hyperreactivity.
Topics: Animals; Body Fluids; Bronchi; Bronchial Provocation Tests; Bronchial Spasm; Citrates; Citric Acid; Cytoplasmic Granules; Disease Models, Animal; Dog Diseases; Dogs; Histamine; Leukocyte Count; Leukocytes; Mast Cells; Methacholine Chloride; Methacholine Compounds; Pulmonary Alveoli; Staining and Labeling; Therapeutic Irrigation | 1986 |
Comparison of drug responses in vivo and in vitro in airways of dogs with and without airway hyperresponsiveness.
Topics: Aerosols; Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Disease Models, Animal; Dogs; Histamine; In Vitro Techniques; Isoproterenol; Methacholine Chloride; Methacholine Compounds; Muscle Contraction; Muscle, Smooth | 1986 |
Airway responsiveness to inhaled antigen, histamine, and methacholine in inbred, ragweed-sensitized dogs.
Topics: Animals; Asthma; Bronchial Provocation Tests; Disease Models, Animal; Dogs; Female; Histamine; Immunization; Immunoglobulin E; Male; Methacholine Chloride; Methacholine Compounds; Pollen; Radioallergosorbent Test; Skin Tests | 1985 |