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methacholine chloride and Disease Models, Animal

methacholine chloride has been researched along with Disease Models, Animal in 331 studies

Research

Studies (331)

TimeframeStudies, this research(%)All Research%
pre-19905 (1.51)18.7374
1990's52 (15.71)18.2507
2000's138 (41.69)29.6817
2010's121 (36.56)24.3611
2020's15 (4.53)2.80

Authors

AuthorsStudies
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV1
Choi, JH; Kim, JY; Kim, M; Yi, MH; Yong, TS1
Ather, JL; Barup, MLT; Mank, MM; Poynter, ME; Reed, LF; Walton, CJ1
Henry, PJ; Landwehr, KR; Larcombe, AN; Mann, TS; Noble, PB; Shamsuddin, D; Wang, KCW1
Takeda, K1
Feng, Y; Li, L; Li, Z; Liu, L; Ma, S; Wang, J; Wang, X; Wang, Z; Yang, K; Zhu, Y; Zhu, Z1
Einisman, HJ; Gaston, B; Lewis, SJ; Lewis, TH; Raffay, TM; Smith, LA; Wijers, C1
Azimi, S; Hall, IP; Henry, AP; Kotlikoff, MI; Lee, FK; Lee, JC; Liu, B; Miller, S; Probert, K; Sayers, I1
Kaczyńska, K; Russjan, E1
Dong, L; Liu, SF; Nie, Q; Niu, Y; Song, D; Song, W; Wang, X; Wu, G; Zhang, J1
Bowser, JE; Byars, P; Byrne, R; Hunter, CL; Moore, JW; Swiderski, CE; Wills, RW; Wilson, RM1
Contaifer, D; Dileepan, M; Ge, XN; Greenberg, YG; Ha, SG; Rao, SP; Rastle-Simpson, S; Sriramarao, P; Wijesinghe, DS1
Hirai, K; Homma, T; Ida, H; Jinno, M; Kashima, A; Kimura, T; Miyata, Y; Ohta, S; Sagara, H; Sato, H; Suganuma, H; Suzuki, S; Tanaka, A; Uno, T; Watanabe, Y; Yamamoto, M1
Chan, WM; Chen, J; Ko, KM; Leong, PK; Leung, HY; Yan, CTM1
Kiskurno, S; Kumar, VH; Paturi, B; Ryan, RM; Wang, H1
Cui, J; Dong, J; Dong, M; Qin, J; Tang, W; Teng, F; Wang, S; Wang, W; Wei, Y; Wuniqiemu, T; Zhu, X1
Abma, W; Adner, M; Alvarado-Vazquez, PA; Feyerabend, TB; Hallgren, J; Janson, C; Malinovschi, A; Mendez-Enriquez, E; Rodewald, HR; Rodin, S; Simonson, OE1
Babik, B; Balogh, AL; Fodor, GH; Ivankovitsne-Kiss, O; Petak, F; Sudy, R1
Baudat, A; Bayat, S; Doras, C; Eigenmann, P; Habre, W; Petak, F; Von Garnier, C1
Eslami-Behroozi, M; Javan, M; Raoufy, MR1
Abo, M; Fujimura, M; Hara, J; Kasahara, K; Katayama, N; Nakao, S; Ohkura, N; Okazaki, A; Sakai, T1
Fu, T; Han, L; Sheng, B; Wang, L; Zeng, Q; Zhang, Y1
Abel, PW; Aggarwal, A; Bockman, CS; Deodhar, M; Hallgren, J; Iyer, SH; Kansal, V; Matthews, SA; Netzel, L; Oldenburg, PJ; Simeone, KA; Simeone, TA1
Boskabady, MH; Eftekhar, N; Moghimi, A1
Cavalcante, FSÁ; Gomes, MDM; Leal-Cardoso, JH; Serra, DS1
Albu, G; Bayat, S; Broche, L; Dégrugilliers, L; Fodor, GH; Habre, W; Peták, F; Porra, L; Sovijärvi, ARA; Strengell, S; Suhonen, H; Suortti, P1
Bourque, G; Chiwara, V; de Sanctis, JB; Ho, B; Jeannotte, L; Kanagaratham, C; Moussette, S; Naumova, AK; Radzioch, D; Venuto, D; Youssef, M1
Ilka, F; Javan, M; Raoufy, MR1
Altieri, A; Basu, S; Halayko, AJ; Hemshekhar, M; Hiemstra, PS; Mookherjee, N; Piyadasa, H; van der Does, AM1
Aierken, A; Xu, P1
Chen, CM; Chiang, BL; Chou, HC; Lin, SC1
Hur, J; Kang, JY; Kim, IK; Kim, YK; Lee, J; Lee, JH; Lee, SY; Rhee, CK; Yoon, HJ; Yoon, HK1
Alipour, MR; Aslani, MR; Boskabady, MH; Ghobadi, H; Keyhanmanesh, R1
Britt, RD; Faksh, A; Fang, YH; Freeman, MR; Kuipers, I; Manlove, LJ; Pabelick, CM; Prakash, YS; Thompson, MA; Vogel, ER; Yang, B1
Gounni, AS; Halayko, AJ; Mohammed, A; Movassagh, H; Ojo, OO; Shan, L1
de Beer, R; de Vos, AF; Morgan, BP; Ramirez Moral, I; Roelofs, JJTH; van 't Veer, C; van der Poll, T; Yang, J1
Gauvreau, GM; Grasemann, H; Inman, MD; Khanna, N; North, ML; Scott, JA1
Chen, L; Deng, Z; Gao, ZC; Ge, HQ; Pu, XP; Sun, SY; Wu, DY; Zhang, LR; Zhou, JJ; Zhu, ZP1
Hartney, JM; Robichaud, A1
Bailey, S; Bourke, JE; Donovan, C; Esposito, J; Ibrahim, ZA; Royce, SG; Tang, ML; Tran, J1
Fei, F; Gong, D; Groffen, J; Heisterkamp, N; Lim, M; Yu, M1
Chen, L; Lai, K; Zhong, N1
Amria, M; Bell, PD; Bunni, MA; Estell, KP; Flume, P; Gilley, SK; Gooz, M; Haycraft, CJ; Miller, C; Pasek, RC; Pavlik, JA; Sas, KM; Schwiebert, LM; Sisson, JH; Steele, SL; Stenbit, AE; Turner, GA; Yoder, BK1
Carlier, V; De Vooght, V; Devos, FC; Haenen, S; Hoet, PH; Nemery, B; Vanoirbeek, JA; Verbeken, E1
Aliyeva, M; Anathy, V; Daphtary, N; Dixon, AE; Goldman, DH; Hoffman, SM; Irvin, CG; Lahue, KG; Nolin, JD; Poynter, ME; Tully, JE1
Cardoso, WV; Chen, F; Cruikshank, WW; Fine, A; Kim, YK; Marquez, H; Qian, J; Quadro, L; Shao, F1
Brito, JM; Cabral, LD; de Brito Cervilha, DA; Garcia, ÉK; Moriya, HT; Santos, LM; Soncini, R; Teixeira, VP1
Aronsson, P; Carlsson, T; Tobin, G; Winder, M1
Johnson, AC; Lawrence, BP; Lojovich, SJ; O'Reilly, MA; Regal, JF1
Gu, W; Mao, S; Shi, Y; Tan, Y1
Beppu, A; Broide, DH; Doherty, TA; Hoffman, HM; McGeough, MD; Miller, M; Mueller, JL; Niwa, M; Pena, CA; Rosenthal, P; Suzukawa, M; Tam, AB1
Asano, T; Ishihara, T; Kobayashi, D; Kurotsu, S; Maruyama, T; Mizushima, T; Suzuki, H; Tanaka, K; Watanabe, H; Yamakawa, N; Yamashita, Y; Yamazaki, H1
Bergquist, M; Hanrieder, J; Hedenstierna, G; Hjoberg, J; Jonasson, S1
Chu, YH; Kao, CH; Liu, SC; Wang, HW; Wu, CC1
Awadalla, MA; Fischer, AJ; Hoegger, MJ; Hoffman, EA; McMenimen, JD; Michalski, AS; Moninger, TO; Ostedgaard, LS; Stoltz, DA; Tucker, AJ; Welsh, MJ; Zabner, J1
Allen, JS; Caruthers, SD; Eldridge, L; Jenkins, J; Keupp, J; Lanza, GM; Mitzner, W; Moldobaeva, A; Schmieder, A; Wagner, EM; Wickline, SA; Yang, X; Zhang, H; Zhang, Q1
Arikan-Ayyildiz, Z; Bagriyanik, A; Firinci, F; Karaman, M; Karaman, O; Kiray, M; Uzuner, N; Yilmaz, O1
Armani, MH; Barone, CA; Barthold, JS; Boyce, R; Kreiger, PA; Michelini, KA; Rodriguez, E; Shaffer, TH; Waldman, SA; Wang, J; Wolfson, MR; Zhu, Y1
Chen, PJ; Ko, JL; Lee, YT; Lue, KH; Wu, CT1
Armani, MH; Hobson, GM; Kreiger, PA; Rodriguez, E; Sakowski, L; Shaffer, TH; Waldman, SA; Zhu, Y1
Chow, CW; Evans, GJ; Godri Pollitt, K; Khanna, N; Scott, JA; Wang, X; Wu, J1
Fereydoonzad, L; Robichaud, A; Schuessler, TF1
Boskabady, MH; Gholami Mahtaj, L; Mohamadian Roshan, N1
Aronsson, P; Bergquist, F; Carlsson, T; Mitra, R; Tobin, G; Winder, M1
Dodam, JR; Graham, A; Grobman, M; Outi, H; Reinero, CR1
Al-Salam, S; Ali, BH; Beegam, S; Nemmar, A; Yuvaraju, P1
Chan, TK; Cheng, C; Fong, CW; Ho, WE; Lim, AY; Ong, CN; Peh, HY; Seng, KY; Seow, AC; Wong, WS1
Essilfie, AT; Hansbro, PM; Harding, R; Horvat, JC; O'Reilly, M; Sozo, F1
Benedetti, A; Fereydoonzad, L; Martin, JG; McGovern, TK; Novali, M; Robichaud, A; Schuessler, TF; Shalaby, KH1
Bates, G; Benedetti, A; Ijpma, G; Kachmar, L; Lauzon, AM; Lavoie, JP; Matusovsky, OS; Zitouni, N1
Britt, RD; Faksh, A; Kuipers, I; Martin, RJ; Pabelick, CM; Prakash, YS; Sieck, GC; Thompson, MA; Vogel, ER1
Elverdin, JC; Fernández-Solari, J; Martinel Lamas, DJ; Medina, VA; Mohn, C; Perazzo, JC; Prestifilippo, JP; Rios, CE; Rivera, ES1
Aliyeva, MI; Ather, JL; Bates, JH; Chung, M; Daphtary, NA; Dixon, AE; Forgione, PM; Georgsdottir, A; Hoyt, LR; Irvin, CG; Poynter, ME; Randall, MJ; Russell, SR; Suratt, BT1
Dennery, PA; Ito, M; Namba, F; Ogawa, R; Tamura, M; Watanabe, T1
Bongianni, F; Cinelli, E; Iovino, L; Mutolo, D; Pantaleo, T1
Kelada, SN1
Bartsch, JW; Chen, J; Deng, L; Dreymüller, D; Duan, Y; Jiang, X; Koller, G; Lin, F; Long, J; Luo, M; Mao, L; Müller, B; Wang, Y1
Li, C; Luo, Z; Lv, S; Ming, M; Sun, Q1
Guo, H; Hao, Y; Hui, Y; Ren, F; Wang, X; Zhao, L1
August, A; Bonneau, RH; Bourne, RA; Caruso, MJ; Caulfield, JI; Cavigelli, SA; Chirichella, NR; Craig, T; Klein, LC; Michael, KC1
Bae, BR; Chang, YS; Cho, SH; Choi, SJ; Kang, HR; Kang, SY; Lee, HS; Lee, JW; Min, KU; Oh, WI; Park, DE; Park, HW; Sohn, KH; Song, WJ1
Castrop, H; Kunzelmann, K; Schreiber, R1
Bozanich, EM; Gualano, RC; Hantos, Z; Larcombe, AN; Sly, PD; Turner, DJ; Zosky, GR1
Campbell, H; Karmouty-Quintana, H; Martin, JG; McGovern, T; Ramos-Barbón, D; Tuck, SA1
Shore, SA; Williams, ES; Zhu, M1
Jancar, S; Landgraf, RG1
Belmonte, KE; Berlanga, M; Budzik, B; Burman, M; Foley, JJ; Jin, J; Lainé, DI; Moore, ML; Morrow, DM; Palovich, M; Rivero, RA; Salmon, M; Sarau, HM; Shi, D; Wan, Z; Wang, F; Wang, Y; Webb, EF; Xie, H; Zhu, C1
Freyschmidt, EJ; Mathias, CB; Oettgen, HC1
Hedenstierna, G; Hedenström, H; Hjoberg, J; Jonasson, S1
Bullens, D; El Bakkoury, M; Garcia, L; Jacquet, A; Marchand, C; Mattéotti, C; Vandenbranden, M; Walgraffe, D1
Bond, RA; Dickey, BF; Hanania, NA; Knoll, BJ; Lin, R; Nguyen, LP; Omoluabi, O; Parra, S; Tuvim, MJ1
Beume, R; Braun, A; Hoymann, HG; Korolewitz, R; Krug, N; Muller, M; Wollin, L1
Gombos, RB; Hemmings, DG; McDonald, K; Wolan, V1
Acciani, TH; Deutsch, GH; Hardie, WD; Khurana Hershey, GK; Korfhagen, TR; Kramer, EL; Le Cras, TD; Mushaben, EM; Pastura, PA; Whitsett, JA1
Chen, BT; Driehuys, B; Foster, WM; Potts, EN; Slipetz, DM; Thomas, AC1
Chaudhary, D; Deng, B; Goldman, S; Ho, MW; Kasaian, M; Krane, CM; Mason, L; McDonald, CA; Mutyam, V; Pazdziorko, S; Williams, C1
de Mora, F; Herrerias, A; Marco, A; Picado, C; Roca-Ferrer, J; Serra, M; Torres, R1
De Vooght, V; Hoet, PH; Nemery, B; Synhaeve, N; Vanoirbeek, JA1
Bai, Y; Sanderson, MJ1
Ki, SH; Kim, SG; Kim, YM; Lee, CH; Lee, SJ; Lee, WH1
De Vooght, V; Haenen, S; Hoet, PH; Nemery, B; Vanoirbeek, JA; Verbeken, E2
Burchell, JT; Holt, PG; Larcombe, AN; Sly, PD; Stumbles, PA; Turner, DJ; von Garnier, C; White, OJ; Wikstrom, ME; Zosky, GR1
Bayat, S; Habre, W; Hantos, Z; Janosi, TZ; Petak, F; Porra, L; Sovijärvi, AR; Strengell, S; Suhonen, H; Suortti, P1
Cataldo, DD; Crahay, C; Foidart, JM; Gueders, MM; Hacha, J; Louis, R; Noël, A; Paulissen, G; Quesada-Calvo, F; Tournoy, K; Van Hove, C1
Ishii, H; Kondo, T; Kondo, Y; Tanigaki, T; Tazaki, G; Tsuji, C1
Inoue, K; Ishii, T; Koike, E; Takano, H; Warabi, E; Yanagawa, T; Yanagisawa, R1
Hassan, M; Labonté, I; Lauzon, AM; Laviolette, M; Martin, JG; Risse, PA; Tsuchiya, K1
Adori, C; Komlósi, ZI; Kovács, L; Kozma, GT; Losonczy, G; Pállinger, E; Rusai, K; Szabó, A; Szebeni, B; Sziksz, E; Vannay, A1
Bánfi, A; Baráti, L; Bari, F; Novák, Z; Peták, F; Székely, E; Tóth-Szüki, V1
Bullens, DM; Cadot, P; Ceuppens, JL; Meyts, I; Vanaudenaerde, B; Vanoirbeek, JA1
Beghetti, M; Fontao, F; Habre, W; Janosi, TZ; Pache, JC; Peták, F; Regli, A; von Ungern-Sternberg, BS1
Cruz, MJ; De Vooght, V; Haenen, S; Hoet, PH; Morell, F; Muñoz, X; Nemery, B; Vanoirbeek, JA; Wijnhoven, K1
Bassett, D; Doyon-Reale, N; Gao, X; Hirata, F; Kannan, R; Kerr, J; Lieh-Lai, M; Wilson, S1
Gelfand, EW; Larsen, ST; Matsubara, S; McConville, G; Poulsen, SS1
Blacquière, MJ; Geerlings, M; Hylkema, MN; Melgert, BN; Postma, DS; Timens, W1
Bissonnette, EY; Careau, E; Lauzon-Joset, JF; Turmel, V1
Asano, T; Hasegawa, Y; Ito, S; Kume, H; Taki, F1
Hedenstierna, G; Hjoberg, J; Jonasson, S1
Gold, LG; Martin, JG; Robichaud, A; Schuessler, TF; Shalaby, KH1
Cleave, J; Gordon, JR; Town, J; Willson, PJ1
Chung, YJ; Copeland, LB; Doerfler, DL; Ward, MD1
Choi, JP; Choi, SJ; Elias, JA; Gho, YS; Jeon, SG; Kim, YK; Kim, YS; Lee, BJ; Lee, CG; Oh, S-; Zhu, Z1
Ab'Saber, AM; Abreu, SC; Antunes, MA; Capelozzi, VL; Ferreira, TP; Martins, MA; Parra-Cuentas, ER; Rocco, PR; Silva, AL; Silva, PM1
Foong, RE; Larcombe, AN; Sly, PD; Zosky, GR1
Inoue, K; Koike, E; Takano, H1
Clynen, E; De Vooght, V; Haenen, S; Hoet, PH; Maes, E; Nemery, B; Schoofs, L; Vanoirbeek, JA1
Chin, K; Sakai, R; Torii, K; Yoneda, J1
Ellis, R; Inman, MD; Labiris, NR; Turi, GJ; Wattie, JN1
Amer, M; Chiarenza, AP; Elverdin, JC; Fernández-Solari, J; Medina, VA; Vacas, MI1
Bauer, A; Gleason, AM; Golden, G; Kielian, T; Oldenburg, P; Poole, JA; Romberger, DJ; Sisson, JH; West, WW; Wyatt, TA1
Chu, X; Ci, X; Deng, X; Hua, S; Wei, D; Wei, M1
Borate, B; Brass, DM; Carpenter, DE; Collins, FS; Cook, DN; Evans, CM; Kelada, SN; Kubalanza, K; Maruoka, S; Olive, M; Roy, MG; Schwartz, DA; Tavarez, U; Whitehead, GS; Wilson, MS; Wynn, TA1
Basu, S; Fan, Y; Halayko, AJ; Kadkhoda, K; Qiu, H; Wang, S; Yang, X1
El-Osta, A; Karagiannis, TC; Li, X; Orlowski, C; Royce, SG; Tang, ML; Tang, MM1
Fehrenbach, H; Garn, H; Kerzel, S; Maier, RF; Preisser, K; Rogosch, T; Schroeder, HW; Wagner, J; Yildirim, AÖ; Zemlin, M1
Ellis, R; Feng, M; Inman, MD; Lu, WY; Wang, S; Wattie, J; Xiang, YY1
Butte, AJ; Eckart, MR; Galli, SJ; Morgan, AA; Mukai, K; Tsai, M; Yu, M1
Foster, MW; Michael Foster, W; Potts, EN; Que, LG; Yang, Z1
Ahn, KS; Jang, HY; Jeong, H; Kim, SM; Kwon, OK; Lee, HK; Oh, SR; Yuk, JE1
Bloksma, N; Maazi, H; Nawijn, MC; Shirinbak, S; van Oosterhout, AJ1
Debaun, MR; Feroah, TR; Hillery, CA; Holzhauer, SL; Hutchins, W; Nandedkar, SD; Pritchard, KA; Schulte, ML; Strunk, RC1
Barrett, EG; Day, KC; Gigliotti, AP; Mauderly, JL; McDonald, JD; Reed, MD; Seilkop, SK1
Bellusci, S; Belperio, J; Corral, J; Karadag, A; Li, Y; Rehan, VK; Sakurai, R; Torday, JS; Xue, YY1
Carter, L; Gelfand, EW; Hicken, E; Jackson, L; Jia, Y; Robinson, J; Shin, YS; Shiraishi, Y; Takeda, K; Wang, M; Wright, AD1
Batt, J; Correa, J; Khanna, N; North, ML; Plant, PJ; Scott, JA; Ward, A; Ward, M1
Barcham, G; Barker, D; Koumoundouros, E; Snibson, K; Van der Velden, J1
Driehuys, B; Foster, WM; Kaushik, SS; Nouls, J; Potts, EN; Slipetz, DM; Thomas, AC1
Cheng, C; Goh, FY; Guan, S; Leung, BP; Sethi, G; Shanmugam, MK; Upton, N; Wong, WS1
Borthwell, RM; Finkbeiner, WE; Hajighasemi-Ossareh, M; Lachowicz-Scroggins, ME; Modlin, S; Stevens, JE; Widdicombe, JH1
Aliyeva, M; Bates, JH; Lundblad, LK; Stevenson, CA1
Atabai, K; Bernstein, X; Chen, C; Engler, MB; Huang, KE; Huang, X; Kudo, M; Li, JT; Melton, AC; Ren, X; Sheppard, D; Wang, Y1
Cheon, HG; Kwak, HJ; Nam, JY; No, Z; Song, JS; Yang, SD1
Broadley, KJ; Ferrari, N; Ford, WR; Kidd, EJ; Nevin, B; Paquet, L; Renzi, P; Turner, Dl1
Bucht, A; Jonasson, S; Koch, B; Wigenstam, E1
Bauer, C; Gleason, AM; Oldenburg, PJ; Poole, JA; Romberger, DJ; Sisson, JH; West, WW; Wyatt, TA1
Aravamudan, B; Meuchel, LW; Pabelick, CM; Prakash, YS; Sieck, GC; Thompson, M; VanOosten, SK; Vohra, P1
Amatullah, H; Chow, CW; Cooper, J; Godri, K; Khanna, N; North, ML; Penton, PC; Scott, JA; Wang, X1
Chang, HY; Mitzner, W; Watson, J1
Ko, JL; Ku, MS; Lee, SS; Lee, YT; Lu, KH; Lue, KH; Sheu, JN; Sun, HL1
Dong, J; Duan, X; Jin, H; Li, B; Luo, Q; Lv, Y; Nurahmat, M; Wang, G; Wu, J; Zheng, Y1
Albu, G; Beghetti, M; Habre, W; Lele, E; Petak, F1
Howell, MD; Jean Meade, B; Weissman, DN1
Dey, RD; Fedan, JS; Satterfield, BE; Wu, ZX1
Aoki-Nagase, T; Kurihara, H; Kurihara, Y; Nagai, R; Nagase, T; Oh-Hashi, Y; Ohga, E; Ouchi, Y; Shindo, T; Tomita, T; Yamaguchi, Y; Yamamoto, H1
Benser, ME; Ideker, RE; Smith, WM; Walcott, GP; Zheng, X1
Bay, BH; Chua, KY; Duan, W; Kuo, IC; Selvarajan, S; Wong, WS1
Hattori, T; Ichinose, M; Ishigaki-Suzuki, S; Koarai, A; Kuramasu, A; Makabe-Kobayashi, Y; Ohtsu, H; Sakurai, E; Shirato, K; Sugiura, H; Watanabe, T; Yamagata, S1
Clerbaux, T; De Kock, M; Detry, B; Gianello, P; Jolliet, P; Liistro, G; Reynaert, M; Roeseler, J; Veriter, C; Watremez, C1
Chi, EY; Harlan, JM; Henderson, WR; Iwata, A; Nishio, K; Winn, RK1
Işlekel, H; Karaman, O; Kargi, A; Kavukçu, S; Ozkal, S; Soylu, A; Uzuner, N; Yilmaz, O1
Campbell, HR; Eidelman, DH; Gautrin, D; Hamid, Q; Iijima, H; Maghni, K; Malo, JL; Martin, JG1
Clerbaux, T; deKock, M; Detry, B; Gianello, P; Jolliet, P; Liistro, G; Reynaert, M; Roeseler, J; Watremez, C1
Folkerts, G; Hoekstra, MO; Nijkamp, FP; Schijf, MA; Smit, JJ; Van Loveren, H1
Amemiya, T; Fujimura, M; Ishiura, Y; Kurashima, K; Myou, S; Nobata, K; Nonomura, A1
Cui, ZH; Gelfand, EW; Joetham, A; Kanehiro, A; Takeda, K1
Broide, DH; Cho, JY; Ikeda, RK; McElwain, K; McElwain, S; Miller, M; Nayar, J; Raz, E; Walker, L1
Aronica, MA; Boothby, M; Goral, M; McCarthy, S; Mitchell, D; Sheller, JR; Swaidani, S1
Collins, RA; Herbert, C; Kumar, RK; Sly, PD; Turner, DJ1
Archer, AJ; Colasurdo, G; Cramton, JL; Holian, A; Pfau, JC1
Cannet, C; Ellis, KM; Fozard, JR; Mazzoni, L1
Harada, T; Mori, M; Tomioka, S; Tsukagoshi, H; Yoshimi, S1
Bissonnette, EY; Careau, E1
Foster, WM; Liao, G; Peltz, G; Savov, JD; Schwartz, DA; Usuka, J; Wang, J; Whitehead, GS1
Abraha, D; Agrawal, DK; Cho, SH; Oh, CK; Park, JM1
Aydintug, MK; Born, WK; Gelfand, EW; Hahn, YS; Kanehiro, A; Lahn, M; O'Brien, RL; Wands, JM1
Boskabady, MH; Zarei, A1
Ceuppens, JL; Hoet, PH; Nemery, B; Tarkowski, M; Vanoirbeek, JA; Verbeken, EK1
Morimoto, K; Mukaiyama, O; Nosaka, E; Takahashi, S; Yamashita, M2
Dakhama, A; Gelfand, EW; Kodama, T; Miyahara, N; Miyahara, S; Ott, VL; Swanson, BJ; Takeda, K; Taube, C1
Askenase, PW; Campos, RA; Fukui, M; Geba, GP; Homer, RJ; Iliopoulou, BP; Itakura, A; Kawikova, I; Paliwal, V; Pober, JS; Szczepanik, M; Tsuji, RF1
Holt, PG; Sly, PD; Stumbles, PA; Turner, DJ; von Garnier, C; Zosky, GR1
Das, M; Gangal, SV; Ghosh, B; Ram, A1
Flynt, L; Imrich, A; Johnston, RA; Mellema, MS; Schwartzman, IN; Shore, SA1
Fujimura, M; Nakao, S; Nishitsuji, M; Oribe, Y1
Chai, OH; Hwang, PH; Kim, JS; Lee, KS; Lee, MK; Lee, YC; Park, SJ; Song, CH; Yi, HK1
Huang, J; Ideker, RE; Smith, WM; Walcott, GP; Zheng, X1
Aburada, M; Kase, Y; Maruyama, H; Sasaki, T; Takeda, S1
Arantes-Costa, FM; Kasahara, DI; Lopes, FD; Martins, MA; Nunes, MP; Perini, A1
Adachi, M; Akabane, T; Asano, K; Honma, I; Ieki, K; Iwase, M; Kawaguchi, M; Kokubu, F; Kurokawa, M; Matsukura, S; Odaka, M; Suzuki, S; Takeuchi, H; Watanabe, S1
McCusker, CT; Wang, Y1
Choi, IW; Im, SY; Kim, JH; Kim, YS; Ko, HM; Lee, HK; Lee, JH; Lee, YC; Park, YM; You, HJ1
Bates, JH; Irvin, CG; Norton, RJ; Rinaldi, LM; Wagers, SS1
Bonacci, JV; Fernandes, DJ; Quan, L; Stewart, AG; Taylor, CC; Ward, JE1
Blaydon, C; Bonneau, O; Ferretti, S; Stevenson, CS; Trifilieff, A; Wyss, D1
Birolini, D; de Arruda, MJ; Fontes, B; Poggetti, RS; Souza, AL; Younes, RN1
Boothby, M; Davies, SS; Dworski, R; Mernaugh, R; Meyrick, B; Mitchell, D; Peebles, RS; Roberts, LJ; Sheller, JR; Talati, M1
Atkins, C; Colasurdo, GN; Elidemir, O; Fullmer, JJ; Khan, AM; Stark, JM1
Bissonnette, EY; Careau, E; Pouliot, P; Proulx, LI; Spahr, A; Turmel, V1
Lomask, M1
Ahn, K; Joung, H; Kim, DY; Kim, JH; Kwon, OK; Lee, HK; Lee, J; Lee, MY; Lee, S; Oh, SR; Park, BY1
Arata, S; Gabazza, EC; Homma, I; Iwase, M; Kimura, H; Miyamoto, K; Nyui, M; Sakai, Y1
Galli, SJ; Jones, C; Tam, SY; Tsai, M; Yu, M; Zehnder, J1
Deng, JF; Deng, YM; Ke, CK; Shao, CS; Xie, QM; Zhang, H1
Azoulay, E; Gil, FR; Lauzon, AM; Maghni, K; Zitouni, NB1
Ketonen, J; Leinonen, M; Paakkari, I; Saikku, P; Törmäkangas, L1
Guedes, AG; Kannan, MS; Kita, H; Lund, FE; Paulin, J; Rivero-Nava, L1
Adler, KB; Agrawal, A; Dickey, BF; Fahim, M; Ghosh, B; Ram, A; Rengarajan, S1
Chen, JQ; Deng, JF; Deng, YM; Sun, JG; Tang, HF; Xie, QM; Yang, SY1
Ceuppens, J; De Vooght, V; Hoet, PH; Mercier, CM; Nemery, B; Tarkowski, M; Vanhooren, HM; Vanoirbeek, JA1
Bates, JH; Haverkamp, HC; Irvin, CG; Norton, RJ; Sullivan, MJ; Thompson-Figueroa, JA; Wagers, SS1
Clarke, ZL; Lang, D; Lewis, MJ; Miller, AL; Moat, SJ; Randall, MD1
Demant, P; Groot, PC; Hofman, GA; Jeurink, PV; Piavaux, B; Van Oosterhout, AJ1
Bienenstock, J; Forsythe, P; Inman, MD1
Ansari, HR; Fan, M; Jamal Mustafa, S; Ledent, C; Nadeem, A1
Nickell, LE; Snyder, DW; Stengel, PW; Wolos, JA1
Bozanich, EM; Collins, RA; Hantos, Z; Jánosi, TZ; Sly, PD; Thamrin, C; Turner, DJ1
Alenius, H; Haapakoski, R; Husgafvel-Pursiainen, K; Lehto, M; Leino, M; Määttä, J; Savolainen, K; Tillander, S; Wolff, H1
Bonneau, O; Trifilieff, A; Wyss, D1
de Groot, AA; Mathy, MJ; Peters, SL; van Zwieten, PA1
Finlay-Jones, JJ; Gorman, S; Hart, PH; Larcombe, AN; McGlade, JP; Sly, PD; Turner, DJ; Zosky, GR1
Bergren, DR1
Guo, WK; Snyder, DW; Stengel, PW; Wolos, JA; Zeckner, DJ1
Chew, AD; Ellis, R; Hirota, JA; Inman, MD; Janssen, LJ; Wattie, J1
Bozza, M; Cagido, VR; Capelozzi, VL; Dolhnikoff, M; Morales, MM; Negri, EM; Passaro, CP; Rocco, PR; Silva, PL; Zin, WA1
Balhorn, A; Dakhama, A; Gelfand, EW; Joetham, A; Loader, JE; Matsubara, S; Miyahara, N; Ohnishi, H; Swasey, CH; Takeda, K1
Armstrong, SR; Briones, S; Hegde, SS; Horger, B; Jaw-Tsai, S; Richardson, CL1
Burchell, JT; Hantos, Z; Holt, PG; Janosi, TZ; Larcombe, AN; Sly, PD; Turner, DJ; White, OJ; Zosky, GR1
In, M; Iwashita, K; Kawasaki, H; Kuwabara, T; Mataki, Y; Sawada, M1
Ahn, MH; Jang, AS; Kwon, JH; Lee, SH; Lee, YM; Park, CS; Rhim, TY; Song, HM; Takizawa, H1
Carpenter, GH; Correia, PN; Osailan, SM; Paterson, KL; Proctor, GB1
Andersson, MC; Giglio, D; Tobin, G1
Johnston, RA; Lu, FL; Shore, SA; Terry, RD; Theman, TA; Williams, ES1
Broadley, KJ; Fernandez-Rodriguez, S; Ford, WR; Kidd, EJ1
Bates, JH; Cojocaru, A; Haverkamp, HC; Irvin, CG1
Gelfand, EW; Goya, S; Hamelmann, E; Pichavant, M; Umetsu, DT1
Ghosh, B; Mabalirajan, U; Ram, A; Singh, SK; Singh, VP1
Burton, MD; McKenzie, R; Royce, SG; Tang, ML1
Downes, H; Hirshman, CA; Leon, DA; Peters, JE1
Harada, N; Hata, T; Itoh, E; Kita, T1
Knippenberg, RW; Kudlacz, EM1
Fujimura, M; Matsuda, T; Mizuhashi, K; Saito, M; Songür, N; Xiu, QY1
Baur, X; Hoffarth, HP; Marek, W; Potthast, J; Ulmer, WT1
Folkerts, G; Nijkamp, FP; Omini, C; van der Linde, HJ1
Fukata, Y; Fukushima, H; Harada, K; Kaneta, S; Miwa, A; Ogawa, N1
Buikema, H; de Smet, BJ; Lie, KI; Scholtens, E; van Gilst, WH; van Veldhuisen, DJ; Wesseling, H1
Black, C; Curry, C; Emala, C; Hirshman, CA; Levine, MA1
Isono, T; Kohsaka, M; Koibuchi, Y; Mori, J; Ohtsuka, M; Ozaki, R; Sakai, S; Sato, N; Yamamoto, T1
Itoh, K; Mukaiyama, O; Satoh, Y; Takahashi, E; Yamaguchi, T2
Foster, PS; Hogan, SP; Matthaei, KI; Ramsay, AJ; Young, IG1
Marek, W; Ulmer, WT1
Bateman, RD; Beadle, RE; Guthrie, AJ; White, CE1
Andresen, CJ; Smith, WB; Turner, CR; Watson, JW1
Albert, RK; Chi, EY; Chiang, GK; Eriksen, P; Henderson, WR; Jonas, M; Jones, F; Lamm, WJ; Lewis, DB; Tien, YT; Zhang, Y1
Cernadas, M; Christiani, DC; De Sanctis, GT; Donovan, C; Finn, PW; Katona, I; Kobzik, L; Krinzman, SJ; Listman, J; Mark, D; Nassr, K; Perkins, DL; Wang, Y1
Elias, JA; Flavell, RA; Geba, GP; Homer, RJ; Kuhn, C; Ray, P; Tang, W; Zheng, T1
Hessel, EM; Hofman, G; Nijkamp, FP; Savelkoul, HF; Van Ark, I; Van Esch, B; Van Loveren, H; Van Oosterhout, AJ1
Gowski, DT; Hoffman, LA; Lutz, J; Miro, AM; Pinsky, MR; Sigler, DW; Tasota, FJ; Zullo, T1
Long, NC; Martin, JG; Pantano, R; Shore, SA1
Chan, B; Hofstra, CL; Jardieu, PM; Nijkamp, FP; Shields, R; Van Ark, I; Van Oosterhout, AJ1
Gelfand, EW; Hamelmann, E; Irvin, CG; Larsen, GL; Oshiba, A; Schwarze, J; Takeda, K1
Albert, RK; Chi, EY; Christie, PE; Chu, SJ; Harlan, JM; Henderson, WR; Jonas, M; Lamm, WJ; Rochon, Y1
Enhorning, G; van Schaik, SM; Vargas, I; Welliver, RC1
Sly, PD; Uhlig, T; Wildhaber, JH1
Bluestone, JA; Cattamanchi, A; Elliott, D; Herrmann, K; Li, X; Mathur, M; Padrid, PA; Qin, Y; Sperling, AI; Weinstock, J1
Bhan, AK; Brewer, JP; Geha, RS; Martin, TR; Mizoguchi, E; Spergel, JM1
Hall, GL; Peták, F; Sly, PD1
Hofman, G; Hofstra, CL; Kapsenberg, ML; Nijkamp, FP; Savelkoul, HF; Van Ark, I; Van Esch, B; Van Oosterhout, AJ; Weller, FR1
Ishikawa, T; Nishino, T; Sato, J; Shinozuka, N1
Hofman, G; Hofstra, CL; Jardieu, PM; Nijkamp, FP; Van Ark, I; Van Oosterhout, AJ1
De Sanctis, GT; Donovan, CE; Finn, PW; Kobzik, L; Krinzman, SJ; Lederer, J; Linsley, PS; Mark, DA; Perkins, DL; Sayegh, MH1
De Boer, J; Meurs, H; Pouw, FM; Zaagsma, J1
Broide, D; Gelfand, EW; Gifford, T; Malek, S; Martin-Orozco, E; Nguyen, MD; Raz, E; Schwarze, J; Tighe, H; Van Uden, J1
Berry, G; DeKruyff, RH; Hansen, G; Umetsu, DT1
Dawson, CA; Kelly, KJ; Krenz, GS; Kurup, VP; Rickaby, DA; Thakker, JC; Xia, JQ1
Agrawal, DK; Chong, BT; Romero, FA; Townley, RG1
Foster, PS; Hogan, SP; Kumar, RK; Shepherd, DP; Temelkovski, J1
De Sanctis, GT; Drazen, JM; Fabian, AJ; Grasemann, H; Hamada, K; Huang, PL; Jiao, A; Kobzik, L; MacLean, JA; Mehta, S; Scott, JA; Venugopal, CS; Wolyniec, WW; Yandava, CN1
Bice, DE; Collie, DD; Lipscomb, MF; Lyons, CR; Wilder, JA; Wilson, BS1
Baradaran-Hosseini, E; Puddington, L; Schramm, CM; Stengel, P; Thrall, RS; Whiteley, HE; Wolyniec, WW; Yiamouyiannis, CA1
Cooper, RA; Fotuhi, PC; Ideker, RE; Rollins, DL; Smith, WM; Sreenan, CM1
Denburg, JA; Ellis, R; Inman, MD; O'Byrne, PM; Wattie, J1
Angell, T; Bonnefoy, JY; Chvatchko, Y; Dasic, G; Graber, P; Herren, S; Juillard, P; Knowles, R; Kosco-Vilbois, MH1
Ross, DL; Thomas, SP1
Amemiya, T; Fujimura, M; Ishiura, Y; Liu, Q; Matsuda, T; Myou, S; Nobata, K; Tachibana, H1
Chi, EY; Henderson, WR; Maliszewski, CR1
Kohno, S; Mizutani, N; Nabe, T; Sasaki, K; Takenaka, H1
Alarie, Y; Braun, A; Daser, A; Glaab, T; Herz, U; Kips, J; Lommatzsch, M; Neuhaus-Steinmetz, U; Renz, H1
Hamada, H; Hiwada, K; Kohno, N; Sakai, K; Yokoyama, A; Zhao, GD1
Chi, EY; Dietsch, GN; Henderson, WR; Lu, J; Poole, KM1
Holt, PG; Sly, PD; Tulić, MK; Wale, JL1
Galli, SJ; Williams, CM1
Bochnowicz, S; Hart, T; Hay, DW; Louden, C; Luttmann, MA; Osborn, RR; Underwood, DC1
Collins, RD; Graham, BS; Jarzecka, K; Mitchell, DB; Peebles, RS; Sheller, JR1
Fujiwara, Y; Gerard, C; Gerard, NP; Humbles, AA; Israel, E; Lilly, C; Lu, B; Nilsson, CA1
Bouchard, P; Holbert, D; Sur, S; Van Scott, MR1
Bertrand, C; El-Hashim, A; Trifilieff, A1
George, CL; Jin, H; Kline, JN; O'Neill, ME; O'Shaughnessy, P; Phipps, JC; Schwartz, DA; Thorne, PS; Wohlford-Lenane, CL1
Broide, DH; Castaneda, D; Nayar, J; Sriramarao, P; Stachnick, G1
Feldman, S; Fu, SM; Kim, Y; Kuziel, WA; Rose, CE1
Han, SH; Peng, HJ; Su, YC; Tsai, JJ; Wang, SR1
Chu, HW; Harbeck, RJ; Honour, JM; Martin, RJ1
Fiscus, LC; Steeber, DA; Tang, ML; Tedder, TF; Van Herpen, J1
Buescher, H; Fozard, JR1
Doerschuk, CM; Le Blanc, B; Murthy, GG; Schwartzman, IN; Shore, SA1
Deurloo, DT; Hofstra, CL; Nijkamp, FP; van Esch, BC; van Oosterhout, AJ1
Chiang, BL; Hong, RL; Ku, PH; Lai, YL; Lee, YL; Wu, YL; Ye, YL; Yu, CI1
Ishii, S; Nagase, T; Ouchi, Y; Shimizu, T; Shindou, H1
Blease, K; Hogaboam, CM; Schuh, JM1
Foster, PS; Herbert, C; Kumar, RK; Yang, M1
Bates, JH; Irvin, CG; Lundblad, L; Moriya, HT; Wagers, S1
Go, K; Hata, T; Namimatsu, A; Okazaki, R1
Aghili, S; Garland, A; Glagov, S; Hernandez, C; Hershenson, MB; Punjabi, N; Ray, DW; Solway, J1
Adachi, M; Hoshino, H; Kobayashi, H; Kokubu, F; Konno, S; Minoguchi, K; Mita, S; Okazawa, A; Sunouchi, K; Takahashi, T1
Go, K; Hata, T; Namimatsu, A1
Castleman, WL; Lemanske, RF; McAllister, PK; Sorkness, RL1
Austin, DR; Hanifin, JM; Hirshman, CA; Hulbert, W; Klein, W1
Austin, DR; Downes, H; Hirshman, CA; Parks, CM1
Frick, OL; Gold, WM; Hartiala, J; Mapp, C; Shields, RL1

Reviews

1 review(s) available for methacholine chloride and Disease Models, Animal

ArticleYear
Further exploration of the Penh parameter.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2006, Volume: 57 Suppl 2

    Topics: Airway Resistance; Allergens; Animals; Bronchoconstriction; Disease Models, Animal; Methacholine Chloride; Mice; Physical Conditioning, Animal; Plethysmography, Whole Body; Respiratory Mechanics

2006

Trials

2 trial(s) available for methacholine chloride and Disease Models, Animal

ArticleYear
A probative approach for noninvasive evaluation of airway hyperresponsiveness and remodeling in adult asthmatics.
    Lung, 2004, Volume: 182, Issue:1

    Topics: Administration, Inhalation; Adrenal Cortex Hormones; Airway Resistance; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Disease Models, Animal; Female; Humans; Male; Methacholine Chloride; Middle Aged; Models, Biological; Muscle, Smooth; Outcome and Process Assessment, Health Care; Practice Guidelines as Topic; Respiratory Function Tests; Treatment Outcome

2004
A role for the C3a anaphylatoxin receptor in the effector phase of asthma.
    Nature, 2000, Aug-31, Volume: 406, Issue:6799

    Topics: Animals; Antigens, CD; Asthma; Complement C3a; Disease Models, Animal; Female; Humans; Hypersensitivity, Immediate; Lung; Male; Membrane Proteins; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Plethysmography; Receptor, Anaphylatoxin C5a; Receptors, Complement

2000

Other Studies

328 other study(ies) available for methacholine chloride and Disease Models, Animal

ArticleYear
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

2020
    BioMed research international, 2021, Volume: 2021

    Topics: Airway Remodeling; Animals; Anisakis; Antibody Specificity; Biomarkers; Bronchial Hyperreactivity; Cytokines; Disease Models, Animal; Inflammation Mediators; Lung; Methacholine Chloride; Mice, Inbred BALB C; Pneumonia; Th2 Cells

2021
Therapeutic ketosis decreases methacholine hyperresponsiveness in mouse models of inherent obese asthma.
    American journal of physiology. Lung cellular and molecular physiology, 2022, 02-01, Volume: 322, Issue:2

    Topics: 3-Hydroxybutyric Acid; Animals; Asthma; Bronchial Hyperreactivity; Diet, High-Fat; Diet, Ketogenic; Disease Models, Animal; Esters; Gastrointestinal Microbiome; Ketone Bodies; Ketosis; Male; Methacholine Chloride; Mice, Inbred C57BL; Obesity; Weight Loss

2022
Azithromycin inhibits mucin secretion, mucous metaplasia, airway inflammation, and airways hyperresponsiveness in mice exposed to house dust mite extract.
    American journal of physiology. Lung cellular and molecular physiology, 2022, 05-01, Volume: 322, Issue:5

    Topics: Adenosine Triphosphate; Allergens; Animals; Asthma; Azithromycin; Disease Models, Animal; Inflammation; Interleukin-13; Metaplasia; Methacholine Chloride; Mice; Mucins; Mucus; Pyroglyphidae

2022
Measurement of Airway Hyperresponsiveness in Mice.
    Methods in molecular biology (Clifton, N.J.), 2022, Volume: 2506

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Eosinophilia; Immunoglobulin E; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiration Disorders; Respiratory Hypersensitivity

2022
A retro-inverso modified peptide alleviated ovalbumin-induced asthma model by affecting glycerophospholipid and purine metabolism of immune cells.
    Pulmonary pharmacology & therapeutics, 2023, Volume: 78

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Immunoglobulin E; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Ovalbumin; Purines

2023
Tracheomalacia in bronchopulmonary dysplasia: Trachealis hyper-relaxant responses to S-nitrosoglutathione in a hyperoxic murine model.
    Pediatric pulmonology, 2019, Volume: 54, Issue:12

    Topics: Animals; Asthma; Bronchodilator Agents; Bronchopulmonary Dysplasia; Disease Models, Animal; Humans; Hyperoxia; Infant, Newborn; Methacholine Chloride; Mice; Muscle, Smooth; S-Nitrosoglutathione; Signal Transduction; Trachea; Tracheomalacia

2019
Exposure to lipopolysaccharide (LPS) reduces contractile response of small airways from GSTCD-/- mice.
    PloS one, 2019, Volume: 14, Issue:9

    Topics: Animals; Bronchioles; Disease Models, Animal; Female; Gene Knockout Techniques; Glutathione Transferase; Lipopolysaccharides; Male; Methacholine Chloride; Mice; Muscle Contraction; Tumor Necrosis Factor-alpha; Up-Regulation

2019
Beneficial Effects of Neurotensin in Murine Model of Hapten-Induced Asthma.
    International journal of molecular sciences, 2019, Oct-11, Volume: 20, Issue:20

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Gene Expression Regulation; Haptens; Humans; Injections, Intraperitoneal; Leukocytes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neurotensin; Pyrazoles; Quinolines

2019
Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch.
    Scientific reports, 2020, 02-06, Volume: 10, Issue:1

    Topics: Animals; Asthma; Bronchoconstrictor Agents; Cells, Cultured; Disease Models, Animal; Female; Glycolysis; Humans; Hydrogen; Lactic Acid; Leukocytes, Mononuclear; Lung; Male; Methacholine Chloride; Mice; Middle Aged; Ovalbumin; Oxidative Phosphorylation; Primary Cell Culture

2020
Airway Hyperresponsiveness Is Severe and Persistent in an Equine Model of Neutrophilic Asthma.
    American journal of respiratory cell and molecular biology, 2020, Volume: 62, Issue:6

    Topics: Airway Remodeling; Animals; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Disease Models, Animal; Horse Diseases; Horses; Humans; Methacholine Chloride; Neutrophils; Respiratory Hypersensitivity; Species Specificity

2020
Pulmonary delivery of ORMDL3 short hairpin RNA - a potential tool to regulate allergen-induced airway inflammation.
    Experimental lung research, 2020, Volume: 46, Issue:7

    Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Inflammation; Lung; Male; Membrane Proteins; Methacholine Chloride; Mice; Mice, Knockout; Mice, Transgenic; Pulmonary Eosinophilia; Respiratory Hypersensitivity; RNA Interference; RNA, Small Interfering

2020
The Effect of Bronchoconstriction by Methacholine Inhalation in a Murine Model of Asthma.
    International archives of allergy and immunology, 2020, Volume: 181, Issue:12

    Topics: Administration, Inhalation; Allergens; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Eosinophils; Female; Humans; Lung; Macrophages; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Transforming Growth Factor beta

2020
Anti-Inflammatory Effects of a
    Molecules (Basel, Switzerland), 2020, Sep-04, Volume: 25, Issue:18

    Topics: Animals; Anti-Inflammatory Agents; Asthma; beta-N-Acetylhexosaminidases; Body Weight; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Capsaicin; Cordyceps; Cytokines; Disease Models, Animal; Eosinophil Peroxidase; Female; Histamine Release; Immunization; Immunoglobulin E; Mast Cells; Methacholine Chloride; Mice, Inbred BALB C; Mycelium; Nasal Lavage; Ovalbumin; Rats, Sprague-Dawley; Rhinitis, Allergic; Skin; Spleen; Trachea

2020
Antioxidant MnTBAP does not protect adult mice from neonatal hyperoxic lung injury.
    Respiratory physiology & neurobiology, 2020, Volume: 282

    Topics: Animals; Animals, Newborn; Antioxidants; Bronchoconstrictor Agents; Bronchopulmonary Dysplasia; Disease Models, Animal; Female; Hyperoxia; Male; Metalloporphyrins; Methacholine Chloride; Mice; Mice, Inbred C57BL; Plethysmography, Whole Body; Pregnancy

2020
TMT-based quantitative proteomics reveals suppression of SLC3A2 and ATP1A3 expression contributes to the inhibitory role of acupuncture on airway inflammation in an OVA-induced mouse asthma model.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 134

    Topics: Acupuncture Therapy; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Fusion Regulatory Protein 1, Heavy Chain; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucus; Ovalbumin; Proteomics; Respiratory Hypersensitivity; Sodium-Potassium-Exchanging ATPase

2021
Mast cell-derived serotonin enhances methacholine-induced airway hyperresponsiveness in house dust mite-induced experimental asthma.
    Allergy, 2021, Volume: 76, Issue:7

    Topics: Animals; Asthma; Disease Models, Animal; Humans; Lung; Mast Cells; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pyroglyphidae; Serotonin

2021
Levosimendan prevents bronchoconstriction and adverse respiratory tissue mechanical changes in rabbits.
    American journal of physiology. Lung cellular and molecular physiology, 2017, Nov-01, Volume: 313, Issue:5

    Topics: Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchoconstriction; Cardiac Output; Disease Models, Animal; Glyburide; Hydrazones; KATP Channels; Lung; Male; Methacholine Chloride; Pyridazines; Rabbits; Simendan

2017
Lung responses in murine models of experimental asthma: Value of house dust mite over ovalbumin sensitization.
    Respiratory physiology & neurobiology, 2018, Volume: 247

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Lung; Methacholine Chloride; Mice, Inbred BALB C; Muscle, Smooth; Ovalbumin; Pneumonia; Pyroglyphidae; Respiratory Mechanics

2018
Effect of airway remodeling and hyperresponsiveness on complexity of breathing pattern in rat.
    Respiratory physiology & neurobiology, 2018, Volume: 247

    Topics: Airway Remodeling; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Inflammation; Male; Methacholine Chloride; Random Allocation; Rats, Sprague-Dawley; Respiration; Respiratory Hypersensitivity; Specific Pathogen-Free Organisms

2018
Role of prostaglandin E
    Pulmonary pharmacology & therapeutics, 2018, Volume: 48

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cough; Cysteine; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Epoprostenol; Guinea Pigs; Leukotrienes; Male; Methacholine Chloride; Receptors, Prostaglandin E

2018
Ghrelin Ameliorates Asthma by Inhibiting Endoplasmic Reticulum Stress.
    The American journal of the medical sciences, 2017, Volume: 354, Issue:6

    Topics: Animals; Anti-Asthmatic Agents; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Endoplasmic Reticulum; Ghrelin; Keratins; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Stress, Physiological

2017
Respiratory dysfunction progresses with age in Kcna1-null mice, a model of sudden unexpected death in epilepsy.
    Epilepsia, 2018, Volume: 59, Issue:2

    Topics: Animals; Apnea; Bronchoconstrictor Agents; Death, Sudden; Disease Models, Animal; Disease Progression; Epilepsy; Epilepsy, Temporal Lobe; Gene Expression; Hyperventilation; Hypoxia; Kv1.1 Potassium Channel; Methacholine Chloride; Mice; Mice, Knockout; Muscle, Smooth; Respiratory Insufficiency; Reverse Transcriptase Polymerase Chain Reaction; Tachypnea; Tidal Volume; Trachea

2018
Prophylactic effect of rosmarinic acid on tracheal responsiveness, white blood cell count and oxidative stress markers in lung lavage of sensitized rats.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Bronchoalveolar Lavage Fluid; Cinnamates; Depsides; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Leukocytes; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Ovalbumin; Oxidative Stress; Rats, Wistar; Respiratory Hypersensitivity; Rosmarinic Acid; Trachea

2018
Essential oil of Croton Zehntneri attenuates lung injury in the OVA-induced asthma model.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 2019, Volume: 56, Issue:1

    Topics: Animals; Asthma; Brazil; Croton; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Lung; Lung Injury; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Oils, Volatile; Ovalbumin; Phytotherapy; Plant Leaves; Respiratory Mechanics

2019
Quantitative Imaging of Regional Aerosol Deposition, Lung Ventilation and Morphology by Synchrotron Radiation CT.
    Scientific reports, 2018, 02-23, Volume: 8, Issue:1

    Topics: Administration, Inhalation; Aerosols; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Humans; Iodine; Lung; Methacholine Chloride; Multimodal Imaging; Pulmonary Ventilation; Rabbits; Synchrotrons; Tomography, X-Ray Computed

2018
Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion.
    Mammalian genome : official journal of the International Mammalian Genome Society, 2018, Volume: 29, Issue:3-4

    Topics: Animals; Asthma; Disease Models, Animal; DNA Methylation; Female; Gene Deletion; Gene Expression Regulation; Immunoglobulin E; Lipid Metabolism; Liver; Lung; Male; MAP Kinase Signaling System; Membrane Proteins; Methacholine Chloride; Mice, Inbred C57BL; Mice, Knockout; Organ Specificity; Phenotype; Promoter Regions, Genetic; Respiratory Hypersensitivity; Sex Characteristics; Sphingolipids; Transcriptome

2018
Variable ventilation decreases airway responsiveness and improves ventilation efficiency in a rat model of asthma.
    Respiratory physiology & neurobiology, 2018, Volume: 255

    Topics: Air Pressure; Animals; Asthma; Disease Models, Animal; Male; Methacholine Chloride; Oxygen; Plethysmography, Whole Body; Random Allocation; Rats, Sprague-Dawley; Respiration; Respiration, Artificial; Specific Pathogen-Free Organisms; Tidal Volume

2018
Immunomodulatory innate defence regulator (IDR) peptide alleviates airway inflammation and hyper-responsiveness.
    Thorax, 2018, Volume: 73, Issue:10

    Topics: Animals; Antimicrobial Cationic Peptides; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Cell Culture Techniques; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Female; Humans; Immunomodulation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pyroglyphidae; Respiratory Hypersensitivity

2018
Bacterial respiratory tract inflammation in neonatal rat model is attenuated by benzofuran through inhibition of GATA3.
    Microbial pathogenesis, 2018, Volume: 125

    Topics: Animals; Anti-Asthmatic Agents; Asthma; Benzofurans; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; GATA3 Transcription Factor; Histocytochemistry; Inflammation; Lung; Methacholine Chloride; Rats; Serum; Treatment Outcome

2018
Anti-thymic stromal lymphopoietin antibody suppresses airway remodeling in asthma through reduction of MMP and CTGF.
    Pediatric research, 2019, Volume: 86, Issue:2

    Topics: Airway Remodeling; Animals; Antibodies, Monoclonal; Asthma; Connective Tissue Growth Factor; Cytokines; Disease Models, Animal; Female; Immunoglobulin E; Inflammation; Lung; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Plethysmography; Thymic Stromal Lymphopoietin; Transforming Growth Factor beta

2019
Effect of nintedanib on airway inflammation in a mouse model of acute asthma.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 2020, Volume: 57, Issue:1

    Topics: Acute Disease; Administration, Inhalation; Administration, Oral; Airway Remodeling; Airway Resistance; Animals; Anti-Asthmatic Agents; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Glucocorticoids; Humans; Indoles; Inflammation Mediators; Methacholine Chloride; Mice; Ovalbumin

2020
Effect of High-fat Diet on Tracheal Responsiveness to Methacholine and Insulin Resistance Index in Ovalbumin-sensitized Male and Female Rats.
    Iranian journal of allergy, asthma, and immunology, 2019, Volume: 18, Issue:1

    Topics: Allergens; Animals; Asthma; Blood Glucose; Bronchoconstrictor Agents; Diet, High-Fat; Disease Models, Animal; Female; Insulin; Insulin Resistance; Male; Methacholine Chloride; Obesity; Ovalbumin; Rats, Wistar; Trachea

2019
Caveolin-1 scaffolding domain peptide prevents hyperoxia-induced airway remodeling in a neonatal mouse model.
    American journal of physiology. Lung cellular and molecular physiology, 2019, 07-01, Volume: 317, Issue:1

    Topics: Airway Remodeling; Animals; Animals, Newborn; Anti-Inflammatory Agents; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Caveolin 1; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Hyperoxia; Injections, Intraperitoneal; Lung; Male; Membrane Proteins; Methacholine Chloride; Mice; Oxygen; Peptide Fragments; RNA-Binding Proteins; Signal Transduction

2019
Genetic Deletion of Semaphorin 3E Aggravates Airway Contraction in a Mouse Model of Allergic Asthma.
    American journal of respiratory cell and molecular biology, 2019, Volume: 60, Issue:5

    Topics: Administration, Intranasal; Animals; Asthma; Bronchoconstriction; Cytoskeletal Proteins; Disease Models, Animal; Gene Deletion; Gene Expression; Lung; Membrane Proteins; Methacholine Chloride; Mice; Mice, Knockout; Microtomy; Pyroglyphidae; Recombinant Proteins; Semaphorins; Signal Transduction

2019
Complement factor C5 inhibition reduces type 2 responses without affecting group 2 innate lymphoid cells in a house dust mite induced murine asthma model.
    Respiratory research, 2019, Jul-24, Volume: 20, Issue:1

    Topics: Animals; Asthma; Complement C5a; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Immunity, Innate; Lymphocytes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pyroglyphidae; Th2 Cells

2019
Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma.
    American journal of respiratory cell and molecular biology, 2013, Volume: 48, Issue:6

    Topics: Adolescent; Adult; Animals; Asthma; Disease Models, Animal; Eflornithine; Female; Humans; Hypersensitivity; Inflammation; Lung; Male; Methacholine Chloride; Mice; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Ovalbumin; Polyamines; Spermine; Sputum; Young Adult

2013
Treatment responses of procaterol and CD38 inhibitors in an ozone-induced airway hyperresponsiveness mice model.
    Biological & pharmaceutical bulletin, 2013, Volume: 36, Issue:8

    Topics: ADP-ribosyl Cyclase 1; Animals; Anti-Asthmatic Agents; Benzoates; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Indoles; Leukocyte Count; Lung; Male; Membrane Glycoproteins; Methacholine Chloride; Mice; NF-kappa B; Ozone; Procaterol

2013
Assessment of airway hyperresponsiveness in mouse models of allergic lung disease using detailed measurements of respiratory mechanics.
    Methods in molecular biology (Clifton, N.J.), 2013, Volume: 1032

    Topics: Animals; Asthma; Disease Models, Animal; Humans; Hypersensitivity; Lung; Methacholine Chloride; Mice; Respiratory Mechanics

2013
Differential effects of allergen challenge on large and small airway reactivity in mice.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Airway Remodeling; Allergens; Animals; Antibody Specificity; Bronchial Hyperreactivity; Bronchial Provocation Tests; Calcium; Dinoprostone; Disease Models, Animal; Female; Immunoglobulin E; Inflammation; Methacholine Chloride; Mice; Ovalbumin

2013
Abr, a negative regulator of Rac, attenuates cockroach allergen-induced asthma in a mouse model.
    Journal of immunology (Baltimore, Md. : 1950), 2013, Nov-01, Volume: 191, Issue:9

    Topics: Adoptive Transfer; Allergens; Animals; Asthma; CD4-Positive T-Lymphocytes; Cell Movement; Chemokine CCL21; Disease Models, Animal; Eosinophils; GTPase-Activating Proteins; Immunoglobulin E; Interleukin-4; Interleukin-5; Lung; Methacholine Chloride; Mice; Mice, Knockout; rac GTP-Binding Proteins

2013
Re-challenge with ovalbumin failed to induce bronchial asthma in mice with eosinophilic bronchitis.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Administration, Intranasal; Aerosols; Animals; Asthma; Bronchial Hyperreactivity; Bronchitis; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Female; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Pulmonary Eosinophilia

2013
Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways.
    American journal of physiology. Lung cellular and molecular physiology, 2014, Volume: 306, Issue:2

    Topics: Animals; Bronchial Hyperreactivity; Bronchiectasis; Bronchoconstrictor Agents; Cilia; Ciliary Motility Disorders; Disease Models, Animal; Methacholine Chloride; Mice; Mice, Knockout; Mucociliary Clearance; Respiratory Mucosa; Tumor Suppressor Proteins

2014
B-lymphocytes as key players in chemical-induced asthma.
    PloS one, 2013, Volume: 8, Issue:12

    Topics: Animals; Asthma; B-Lymphocyte Subsets; B7-1 Antigen; B7-2 Antigen; Bronchoconstrictor Agents; CD40 Antigens; Disease Models, Animal; Immunoglobulin E; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, SCID; Toluene 2,4-Diisocyanate

2013
Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis.
    Respiratory research, 2013, Dec-24, Volume: 14

    Topics: Activating Transcription Factor 6; Animals; Apoptosis; Bronchi; Caspase 3; Cell Line; Cells, Cultured; Collagen; Disease Models, Animal; Endoplasmic Reticulum Stress; Epithelial Cells; Humans; In Vitro Techniques; Methacholine Chloride; Mice; Mice, Inbred BALB C; Protein Disulfide-Isomerases; Pulmonary Fibrosis; Pyroglyphidae; RNA, Small Interfering

2013
Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice.
    The Journal of clinical investigation, 2014, Volume: 124, Issue:2

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cell Differentiation; Diet; Disease Models, Animal; Female; Lung; Methacholine Chloride; Mice; Mice, Knockout; Muscle, Smooth; Oligonucleotide Array Sequence Analysis; Phenotype; Pregnancy; Signal Transduction; Tretinoin; Vitamin A; Vitamin A Deficiency

2014
Bronchial responsiveness in an elastase-induced mouse model of emphysema.
    Respiratory physiology & neurobiology, 2014, Apr-01, Volume: 194

    Topics: Animals; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Emphysema; Lung; Male; Methacholine Chloride; Mice; Pancreatic Elastase; Pulmonary Alveoli; Pulmonary Atelectasis; Respiration, Artificial; Respiratory Mechanics; Thorax

2014
Cyclophosphamide-induced alterations of the micturition reflex in a novel in situ urinary bladder model in the anesthetized rat.
    Neurourology and urodynamics, 2015, Volume: 34, Issue:4

    Topics: Adenosine Triphosphate; Afferent Pathways; Animals; Cyclophosphamide; Cystitis; Disease Models, Animal; Dose-Response Relationship, Drug; Efferent Pathways; Electric Stimulation; Male; Mechanotransduction, Cellular; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Pressure; Rats, Sprague-Dawley; Reflex; Time Factors; Urinary Bladder; Urination

2015
Neonatal oxygen exposure alters airway hyper-responsiveness but not the response to allergen challenge in adult mice.
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2014, Volume: 25, Issue:2

    Topics: Age Factors; Airway Resistance; Animals; Animals, Newborn; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Female; Hyperoxia; Lung; Lung Compliance; Male; Methacholine Chloride; Mice, Inbred C57BL; Molecular Sequence Data; Ovalbumin; Pneumonia; Risk Factors; Sex Factors

2014
Naringenin inhibits allergen‑induced airway remodeling in a murine model of asthma.
    Molecular medicine reports, 2014, Volume: 9, Issue:4

    Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Differentiation; Chronic Disease; Cytokines; Disease Models, Animal; Female; Fibrosis; Flavanones; Immunoglobulin E; Inflammation; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucus; Ovalbumin; Th2 Cells

2014
ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma.
    Journal of immunology (Baltimore, Md. : 1950), 2014, Apr-15, Volume: 192, Issue:8

    Topics: Activating Transcription Factor 6; Airway Remodeling; Allergens; Animals; Antibody Specificity; Asthma; Bronchial Hyperreactivity; Chemokines, CC; Chemokines, CXC; Cytokines; Disease Models, Animal; eIF-2 Kinase; Eosinophils; Gene Expression; Gene Order; Gene Targeting; Humans; Immunoglobulin E; Inflammation; Lung; Membrane Proteins; Methacholine Chloride; Mice; Mice, Transgenic; Ovalbumin; Th2 Cells; Transgenes; Unfolded Protein Response

2014
Superiority of pulmonary administration of mepenzolate bromide over other routes as treatment for chronic obstructive pulmonary disease.
    Scientific reports, 2014, Mar-28, Volume: 4

    Topics: Airway Resistance; Animals; Anti-Inflammatory Agents; Benzilates; Disease Models, Animal; Drug Administration Routes; Drug Monitoring; Heart Rate; Male; Methacholine Chloride; Mice; Piperidines; Pulmonary Disease, Chronic Obstructive

2014
Comprehensive multiplexed protein quantitation delineates eosinophilic and neutrophilic experimental asthma.
    BMC pulmonary medicine, 2014, Jul-04, Volume: 14

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Biomarkers; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Female; Hydrocortisone; Inflammation; Inflammation Mediators; Leukocyte Count; Lipopolysaccharides; Mass Spectrometry; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; Phenotype; Protein Array Analysis; Proteome; Respiratory Mechanics

2014
Steroids and antihistamines synergize to inhibit rat's airway smooth muscle contractility.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2015, Volume: 272, Issue:6

    Topics: Animals; Cetirizine; Cholinergic Agents; Disease Models, Animal; Drug Synergism; Electric Stimulation; Glucocorticoids; Histamine Antagonists; Humans; Lung Diseases, Obstructive; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Prednisolone; Rats; Rhinitis, Allergic; Trachea; Treatment Outcome

2015
Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis.
    Science (New York, N.Y.), 2014, Aug-15, Volume: 345, Issue:6198

    Topics: Animals; Animals, Newborn; Anions; Cilia; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Exocrine Glands; Lung; Methacholine Chloride; Mucociliary Clearance; Mucus; Respiratory Mucosa; Respiratory System; Swine; Trachea

2014
Angiogenesis and airway reactivity in asthmatic Brown Norway rats.
    Angiogenesis, 2015, Volume: 18, Issue:1

    Topics: Airway Resistance; Analysis of Variance; Animals; Asthma; Bronchial Arteries; Bronchial Hyperreactivity; Disease Models, Animal; DNA Primers; Fluorocarbons; Lung; Magnetic Resonance Imaging; Methacholine Chloride; Nanoparticles; Neovascularization, Pathologic; Pyroglyphidae; Rats; Real-Time Polymerase Chain Reaction; Silicone Elastomers; Time Factors

2015
Effects of inhaled L-arginine administration in a murine model of acute asthma.
    Iranian journal of allergy, asthma, and immunology, 2014, Volume: 13, Issue:5

    Topics: Acute Disease; Animals; Arginine; Asthma; Bronchoconstrictor Agents; Bronchodilator Agents; Budesonide; Disease Models, Animal; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nitric Oxide; Time Factors

2014
The orl rat is more responsive to methacholine challenge than wild type.
    Pulmonary pharmacology & therapeutics, 2014, Volume: 29, Issue:2

    Topics: Administration, Inhalation; Albuterol; Animals; Anti-Asthmatic Agents; Asthma; Bronchoconstrictor Agents; Cryptorchidism; Disease Models, Animal; Dose-Response Relationship, Drug; Interleukin-4; Interleukin-6; Lung; Male; Methacholine Chloride; Rats, Long-Evans; Tumor Necrosis Factor-alpha

2014
Effects of immunomodulatory supplementation with Lactobacillus rhamnosus on airway inflammation in a mouse asthma model.
    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 2016, Volume: 49, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Immunoglobulin E; Lacticaseibacillus rhamnosus; Lung; Matrix Metalloproteinase 9; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Probiotics

2016
Plp1 gene duplication inhibits airway responsiveness and induces lung inflammation.
    Pulmonary pharmacology & therapeutics, 2015, Volume: 30

    Topics: Albuterol; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gene Duplication; Interleukin-6; Male; Methacholine Chloride; Mice; Myelin Proteolipid Protein; Pelizaeus-Merzbacher Disease; Pneumonia; Respiratory Mechanics

2015
Syk mediates airway contractility independent of leukocyte function.
    Allergy, 2015, Volume: 70, Issue:4

    Topics: Air Pollutants; Airway Resistance; Animals; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Gene Deletion; Intracellular Signaling Peptides and Proteins; Leukocytes; Methacholine Chloride; Mice; Mice, Knockout; Particulate Matter; Phenotype; Protein-Tyrosine Kinases; Respiratory Hypersensitivity; Syk Kinase

2015
Delivered dose estimate to standardize airway hyperresponsiveness assessment in mice.
    American journal of physiology. Lung cellular and molecular physiology, 2015, Apr-15, Volume: 308, Issue:8

    Topics: Administration, Inhalation; Aerosols; Animals; Disease Models, Animal; Humans; Male; Methacholine Chloride; Mice; Nebulizers and Vaporizers; Reference Standards; Research Design; Respiratory Hypersensitivity

2015
The Effect of Zataria multiflora and its Constituent, Carvacrol, on Tracheal Responsiveness and Lung Pathology in Guinea Pig Model of COPD.
    Phytotherapy research : PTR, 2015, Volume: 29, Issue:5

    Topics: Animals; Cymenes; Dexamethasone; Disease Models, Animal; Female; Guinea Pigs; Lamiaceae; Lung; Male; Methacholine Chloride; Monoterpenes; Nicotiana; Plant Extracts; Pulmonary Disease, Chronic Obstructive; Smoke; Trachea

2015
Local Change in Urinary Bladder Contractility Following CNS Dopamine Denervation in the 6-OHDA Rat Model of Parkinson's Disease.
    Journal of Parkinson's disease, 2015, Volume: 5, Issue:2

    Topics: Adenosine Triphosphate; Animals; Corpus Striatum; Denervation; Disease Models, Animal; Dopaminergic Neurons; Electric Stimulation; Male; Methacholine Chloride; Muscarinic Agonists; Muscle Contraction; Oxidopamine; Parkinsonian Disorders; Purinergic Agents; Rats; Rats, Sprague-Dawley; Urinary Bladder

2015
Chronic neurokinin-1 receptor antagonism fails to ameliorate clinical signs, airway hyper-responsiveness or airway eosinophilia in an experimental model of feline asthma.
    Journal of feline medicine and surgery, 2016, Volume: 18, Issue:4

    Topics: Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cat Diseases; Cats; Disease Models, Animal; Eosinophilia; Methacholine Chloride; Neurokinin-1 Receptor Antagonists; Prospective Studies; Random Allocation; Receptors, Neurokinin-1

2016
Emodin mitigates diesel exhaust particles-induced increase in airway resistance, inflammation and oxidative stress in mice.
    Respiratory physiology & neurobiology, 2015, Aug-15, Volume: 215

    Topics: Airway Resistance; Animals; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Emodin; Glutathione; Lipid Peroxidation; Lung; Lung Diseases; Methacholine Chloride; Mice; Mice, Inbred BALB C; Muscarinic Agonists; Oxidative Stress; Particulate Matter; Pneumonia; Protein Kinase Inhibitors; Reactive Oxygen Species; Time Factors

2015
Vitamin E Isoform γ-Tocotrienol Downregulates House Dust Mite-Induced Asthma.
    Journal of immunology (Baltimore, Md. : 1950), 2015, Jul-15, Volume: 195, Issue:2

    Topics: Allergens; alpha-Tocopherol; Animals; Anti-Inflammatory Agents; Antioxidants; Asthma; Bronchoalveolar Lavage Fluid; Chromans; Cytokines; Dermatophagoides pteronyssinus; Disease Models, Animal; Eosinophils; Female; Gene Expression; Immunoglobulin E; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Prednisolone; Reactive Oxygen Species; Vitamin E

2015
Altered lung function at mid-adulthood in mice following neonatal exposure to hyperoxia.
    Respiratory physiology & neurobiology, 2015, Volume: 218

    Topics: Animals; Animals, Newborn; Body Weight; Bronchoconstrictor Agents; Disease Models, Animal; Female; Hyperoxia; Lung; Lung Volume Measurements; Male; Methacholine Chloride; Mice, Inbred C57BL; Sex Characteristics

2015
Mechanical consequences of allergic induced remodeling on mice airway resistance and compressibility.
    Respiratory physiology & neurobiology, 2015, Volume: 218

    Topics: Acute Disease; Airway Remodeling; Airway Resistance; Animals; Bronchoconstrictor Agents; Chronic Disease; Disease Models, Animal; Elasticity; Female; Goblet Cells; Methacholine Chloride; Mice, Inbred BALB C; Muscle, Smooth, Vascular; Ovalbumin; Pulmonary Ventilation; Random Allocation; Respiratory Hypersensitivity; Tidal Volume

2015
Peripheral Airway Smooth Muscle, but Not the Trachealis, Is Hypercontractile in an Equine Model of Asthma.
    American journal of respiratory cell and molecular biology, 2016, Volume: 54, Issue:5

    Topics: Actin Cytoskeleton; Animals; Asthma; Blotting, Western; Ca(2+) Mg(2+)-ATPase; Contractile Proteins; Disease Models, Animal; Female; Horse Diseases; Horses; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Myofibrils; Myosin Heavy Chains; Myosins; Respiratory Mechanics; Trachea

2016
Effects of antenatal lipopolysaccharide and postnatal hyperoxia on airway reactivity and remodeling in a neonatal mouse model.
    Pediatric research, 2016, Volume: 79, Issue:3

    Topics: Airway Remodeling; Animals; Animals, Newborn; Body Weight; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Elastin; Female; Hyperoxia; Inflammation; Lipopolysaccharides; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Oxygen; Pregnancy; Pregnancy, Animal; Respiration; Respiratory System

2016
Pharmacological targeting of histamine H4 receptor in periodontal disease.
    Oral diseases, 2016, Volume: 22, Issue:5

    Topics: Alveolar Bone Loss; Alveolar Process; Animals; Apoptosis; Disease Models, Animal; Gingiva; Histamine Antagonists; Indoles; Male; Methacholine Chloride; Molecular Targeted Therapy; Periodontal Diseases; Periodontitis; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Submandibular Gland

2016
Weight Loss Decreases Inherent and Allergic Methacholine Hyperresponsiveness in Mouse Models of Diet-Induced Obese Asthma.
    American journal of respiratory cell and molecular biology, 2016, Volume: 55, Issue:2

    Topics: Animals; Asthma; Bacteria; Bariatric Surgery; Bronchial Hyperreactivity; Cytokines; Diet; Disease Models, Animal; Hypersensitivity; Inflammation Mediators; Intestines; Male; Methacholine Chloride; Mice, Inbred C57BL; Mice, Obese; Obesity; Weight Loss

2016
Sex-related differences in long-term pulmonary outcomes of neonatal hyperoxia in mice.
    Experimental lung research, 2016, Volume: 42, Issue:2

    Topics: Animals; Animals, Newborn; Bronchioles; Bronchopulmonary Dysplasia; Disease Models, Animal; Female; Hyperoxia; Lung Compliance; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Oxygen; Pulmonary Alveoli; Receptors, Muscarinic; Respiratory Hypersensitivity; Respiratory Mucosa; Sex Characteristics

2016
Downregulation of the cough reflex by aclidinium and tiotropium in awake and anesthetized rabbits.
    Pulmonary pharmacology & therapeutics, 2016, Volume: 38

    Topics: Administration, Inhalation; Anesthesia; Animals; Antitussive Agents; Bronchoconstriction; Bronchodilator Agents; Cough; Delayed-Action Preparations; Disease Models, Animal; Male; Methacholine Chloride; Muscarinic Antagonists; Rabbits; Tiotropium Bromide; Tropanes; Wakefulness

2016
Plethysmography Phenotype QTL in Mice Before and After Allergen Sensitization and Challenge.
    G3 (Bethesda, Md.), 2016, 09-08, Volume: 6, Issue:9

    Topics: Allergens; Animals; Asthma; Disease Models, Animal; Gene-Environment Interaction; Humans; Hypersensitivity; Immunization; Lung; Methacholine Chloride; Mice; Plethysmography; Pyroglyphidae; Quantitative Trait Loci

2016
A novel peptide ADAM8 inhibitor attenuates bronchial hyperresponsiveness and Th2 cytokine mediated inflammation of murine asthmatic models.
    Scientific reports, 2016, 07-26, Volume: 6

    Topics: ADAM Proteins; Animals; Antigens, CD; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Disease Models, Animal; Eosinophils; Gene Expression Regulation; Inflammation; Membrane Proteins; Methacholine Chloride; Mice, Inbred BALB C; Mice, Knockout; Peptides, Cyclic; Receptors, IgE; RNA, Messenger; Solubility; Th2 Cells

2016
The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma.
    Molecular medicine reports, 2017, Volume: 15, Issue:2

    Topics: Administration, Inhalation; Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Interleukin-17; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Mycobacterium phlei; Neutrophils; Ovalbumin; Receptors, Interleukin; Vaccines, Inactivated

2017
Oral administration of Lactobacillus paracasei L9 attenuates PM2.5-induced enhancement of airway hyperresponsiveness and allergic airway response in murine model of asthma.
    PloS one, 2017, Volume: 12, Issue:2

    Topics: Administration, Oral; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Eosinophils; Female; Hypersensitivity; Immunotherapy; Lacticaseibacillus paracasei; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; Particulate Matter; Probiotics; Th1 Cells; Th2 Cells

2017
Peri-adolescent asthma symptoms cause adult anxiety-related behavior and neurobiological processes in mice.
    Behavioural brain research, 2017, 05-30, Volume: 326

    Topics: Age Factors; Animals; Anxiety; Asthma; Behavior, Animal; Disease Models, Animal; Female; Gene Expression; Hippocampus; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Muscarinic Agonists; Pyroglyphidae; Sex Factors

2017
Immunologic regulatory effects of human umbilical cord blood-derived mesenchymal stem cells in a murine ovalbumin asthma model.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2017, Volume: 47, Issue:7

    Topics: Allergens; Animals; Asthma; Cytokines; Disease Models, Animal; Female; Fetal Blood; Humans; Immunization; Immunoglobulin E; Immunomodulation; Inflammation Mediators; Lymph Nodes; Mesenchymal Stem Cells; Methacholine Chloride; Mice; Ovalbumin; Spleen; T-Lymphocyte Subsets

2017
Allergen-induced airway hyperresponsiveness is absent in ecto-5'-nucleotidase (CD73)-deficient mice.
    Pflugers Archiv : European journal of physiology, 2008, Volume: 457, Issue:2

    Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine; Allergens; Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Chlorides; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mucociliary Clearance; Ovalbumin; Trachea

2008
Acute Influenza A infection induces bronchial hyper-responsiveness in mice.
    Respiratory physiology & neurobiology, 2008, Aug-31, Volume: 162, Issue:3

    Topics: Analysis of Variance; Animals; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cell Count; Cytokines; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Female; In Vitro Techniques; Influenza A virus; Influenza Vaccines; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections; Respiratory Hypersensitivity; Time Factors; Vascular Endothelial Growth Factor A

2008
Time course of airway remodelling after an acute chlorine gas exposure in mice.
    Respiratory research, 2008, Aug-14, Volume: 9

    Topics: Animals; Apoptosis; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Proliferation; Chlorine; Disease Models, Animal; Gases; Goblet Cells; Lung; Male; Methacholine Chloride; Mice; Proliferating Cell Nuclear Antigen; Toxicity Tests, Acute

2008
No effect of metformin on the innate airway hyperresponsiveness and increased responses to ozone observed in obese mice.
    Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 105, Issue:4

    Topics: Administration, Oral; Animals; Asthma; Blood Glucose; Body Weight; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Chemokines; Diabetes Mellitus; Disease Models, Animal; Female; Hypoglycemic Agents; Inflammation Mediators; Metformin; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Obese; Neutrophil Infiltration; Obesity; Ozone; Phenotype; Respiratory Mechanics

2008
Endothelin A receptor antagonist modulates lymphocyte and eosinophil infiltration, hyperreactivity and mucus in murine asthma.
    International immunopharmacology, 2008, Dec-20, Volume: 8, Issue:13-14

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Endothelin A Receptor Antagonists; Eosinophils; Lung; Lymphocyte Subsets; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mucus; Ovalbumin; Peptides, Cyclic

2008
Discovery of biphenyl piperazines as novel and long acting muscarinic acetylcholine receptor antagonists.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Administration, Intranasal; Animals; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Methacholine Chloride; Mice; Molecular Structure; Piperazines; Receptors, Muscarinic; Stereoisomerism; Structure-Activity Relationship

2008
Immunoglobulin E antibodies enhance pulmonary inflammation induced by inhalation of a chemical hapten.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2009, Volume: 39, Issue:3

    Topics: Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Count; Chemokine CCL2; Dinitrobenzenes; Disease Models, Animal; Eosinophils; Haptens; Immunization; Immunoglobulin E; Inflammation; Killer Cells, Natural; Lung; Metaplasia; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Natural Killer T-Cells; Occupational Diseases; T-Lymphocytes; Trinitrobenzenesulfonic Acid

2009
Comparisons of effects of intravenous and inhaled methacholine on airway physiology in a murine asthma model.
    Respiratory physiology & neurobiology, 2009, Feb-28, Volume: 165, Issue:2-3

    Topics: Administration, Inhalation; Airway Resistance; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Female; Injections, Intravenous; Lung Compliance; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ovalbumin; Pneumonia; Respiration, Artificial

2009
A hypoallergenic variant of Der p 1 as a candidate for mite allergy vaccines.
    The Journal of allergy and clinical immunology, 2009, Volume: 123, Issue:5

    Topics: Allergens; Animals; Antigens, Dermatophagoides; Arthropod Proteins; Basophils; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cell Line, Tumor; Cloning, Molecular; Cysteine Endopeptidases; Disease Models, Animal; Eosinophilia; Female; Humans; Hypersensitivity; Immunoglobulin E; Interferon-gamma; Interleukin-5; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pyroglyphidae; Rats; Recombinant Proteins; T-Lymphocytes; Vaccines

2009
Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model.
    Proceedings of the National Academy of Sciences of the United States of America, 2009, Feb-17, Volume: 106, Issue:7

    Topics: Alprenolol; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Epithelial Cells; Humans; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phenotype; Receptors, Adrenergic, beta-2; Signal Transduction

2009
Effects of the phosphodiesterase type 4 inhibitor roflumilast on early and late allergic response and airway hyperresponsiveness in Aspergillus-fumigatus-sensitized mice.
    Pharmacology, 2009, Volume: 83, Issue:3

    Topics: Aminopyridines; Animals; Antigens, Fungal; Aspergillus fumigatus; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cyclopropanes; Disease Models, Animal; Eosinophils; Female; Leukocyte Count; Lymphocytes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Phosphodiesterase 4 Inhibitors; Pneumonia; Respiratory Hypersensitivity; Respiratory Mechanics

2009
Impaired vascular function in mice with an active cytomegalovirus infection.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 296, Issue:4

    Topics: Animals; Arteries; beta-Galactosidase; Cytomegalovirus; Cytomegalovirus Infections; Disease Models, Animal; Female; Fetal Weight; Male; Mesentery; Methacholine Chloride; Mice; Mice, Inbred C57BL; Phenylephrine; Placenta; Pregnancy; Uterus; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents

2009
Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice.
    American journal of respiratory cell and molecular biology, 2009, Volume: 41, Issue:4

    Topics: Airway Resistance; Albuterol; Animals; Bronchial Hyperreactivity; Cells, Cultured; Disease Models, Animal; Early Growth Response Protein 1; ErbB Receptors; Fibroblasts; Humans; Hyperplasia; Lung; Lung Compliance; Methacholine Chloride; Mice; Mice, Knockout; Mice, Transgenic; Muscle, Smooth; Muscle, Smooth, Vascular; Pulmonary Artery; Pulmonary Fibrosis; Recombinant Fusion Proteins; Transforming Growth Factor alpha; Weight Loss

2009
A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI.
    NMR in biomedicine, 2009, Volume: 22, Issue:5

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cell Count; Disease Models, Animal; Drug Delivery Systems; Heart Rate; Helium; Imaging, Three-Dimensional; Infusion Pumps; Lung; Magnetic Resonance Imaging; Methacholine Chloride; Mice; Ovalbumin; Pulmonary Ventilation; Reproducibility of Results; Time Factors

2009
Altered regulation of aquaporin gene expression in allergen and IL-13-induced mouse models of asthma.
    Cytokine, 2009, Volume: 46, Issue:1

    Topics: Animals; Aquaporin 1; Aquaporin 4; Aquaporin 5; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Female; Gene Expression Regulation; Inflammation; Interleukin-13; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Models, Biological

2009
Subcutaneous prostaglandin E(2) restrains airway mast cell activity in vivo and reduces lung eosinophilia and Th(2) cytokine overproduction in house dust mite-sensitive mice.
    International archives of allergy and immunology, 2009, Volume: 149, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Chemokine CCL2; Cytokines; Dinoprostone; Disease Models, Animal; Eosinophils; Female; Infusions, Subcutaneous; Lung; Mast Cells; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pulmonary Eosinophilia; Pyroglyphidae; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Th2 Cells

2009
Is toluene diamine a sensitizer and is there cross-reactivity between toluene diamine and toluene diisocyanate?
    Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 109, Issue:2

    Topics: Animals; Antigens, CD; Asthma; Cells, Cultured; Cross Reactions; Cytokines; Disease Models, Animal; Immunoglobulins; Local Lymph Node Assay; Lymphocytes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Phenylenediamines; Statistics, Nonparametric; Toluene 2,4-Diisocyanate

2009
The contribution of Ca2+ signaling and Ca2+ sensitivity to the regulation of airway smooth muscle contraction is different in rats and mice.
    American journal of physiology. Lung cellular and molecular physiology, 2009, Volume: 296, Issue:6

    Topics: Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Calcium; Calcium Signaling; Disease Models, Animal; Male; Membrane Potentials; Methacholine Chloride; Mice; Mice, Inbred BALB C; Muscle, Smooth; Potassium Chloride; Protein Kinase C; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Serotonin; Species Specificity; Temperature; Trachea

2009
Galpha13 regulates methacholine-induced contraction of bronchial smooth muscle via phosphorylation of MLC20.
    Biochemical pharmacology, 2009, May-01, Volume: 77, Issue:9

    Topics: Airway Resistance; Animals; Bronchi; Bronchoconstrictor Agents; Calcium; Cells, Cultured; Disease Models, Animal; GTP-Binding Protein alpha Subunits, G12-G13; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Ovalbumin; Phosphorylation; Respiratory Hypersensitivity; Trachea

2009
Oropharyngeal aspiration: an alternative route for challenging in a mouse model of chemical-induced asthma.
    Toxicology, 2009, May-02, Volume: 259, Issue:1-2

    Topics: Administration, Intranasal; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; Eosinophils; Immunoglobulin E; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Respiratory Aspiration; Toluene 2,4-Diisocyanate; Up-Regulation

2009
Airway hyperresponsiveness is associated with activated CD4+ T cells in the airways.
    American journal of physiology. Lung cellular and molecular physiology, 2009, Volume: 297, Issue:2

    Topics: Airway Resistance; Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Disease Models, Animal; Female; Immunoglobulin E; Immunoglobulin G; Lectins, C-Type; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ovalbumin; Specific Pathogen-Free Organisms

2009
Methacholine and ovalbumin challenges assessed by forced oscillations and synchrotron lung imaging.
    American journal of respiratory and critical care medicine, 2009, Aug-15, Volume: 180, Issue:4

    Topics: Administration, Inhalation; Airway Resistance; Allergens; Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Image Processing, Computer-Assisted; Infusions, Intravenous; Lung; Lung Compliance; Methacholine Chloride; Oscillometry; Ovalbumin; Pulmonary Ventilation; Rabbits; Respiratory Mechanics; Synchrotrons; Tomography, X-Ray Computed

2009
Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2009, Volume: 58, Issue:12

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Humans; Immunoglobulin E; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ovalbumin

2009
Aerosolized methacholine-induced bronchoconstriction and pulmonary hyperinflation in rats.
    The journal of physiological sciences : JPS, 2009, Volume: 59, Issue:5

    Topics: Administration, Inhalation; Aerosols; Animals; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Functional Residual Capacity; Lung; Lung Volume Measurements; Male; Methacholine Chloride; Plethysmography, Whole Body; Rats; Rats, Wistar

2009
Peroxiredoxin I is a negative regulator of Th2-dominant allergic asthma.
    International immunopharmacology, 2009, Volume: 9, Issue:11

    Topics: Airway Resistance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Lung; Methacholine Chloride; Mice; Mice, Knockout; Nitric Oxide; Peroxiredoxins; T-Lymphocytes; Th2 Cells

2009
The effects of repeated allergen challenge on airway smooth muscle structural and molecular remodeling in a rat model of allergic asthma.
    American journal of physiology. Lung cellular and molecular physiology, 2009, Volume: 297, Issue:4

    Topics: Allergens; Animals; Asthma; Blotting, Western; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Disease Models, Animal; Male; Methacholine Chloride; Muscle, Smooth; Ovalbumin; Rats; Rats, Inbred BN; Receptor, Muscarinic M3; Respiratory System; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2009
Galectin-9 in allergic airway inflammation and hyper-responsiveness in mice.
    International archives of allergy and immunology, 2010, Volume: 151, Issue:4

    Topics: Allergens; Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cell Movement; Cytokines; Dexamethasone; Disease Models, Animal; Female; Galectins; Granulocytes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Ovalbumin; Respiratory Function Tests

2010
Airway responsiveness and bronchoalveolar lavage fluid profiling in individual rats: effects of different ovalbumin exposures.
    Respiratory physiology & neurobiology, 2010, Jan-31, Volume: 170, Issue:1

    Topics: Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Methacholine Chloride; Neutrophils; Ovalbumin; Rats; Rats, Wistar; Respiratory Mechanics; Time Factors

2010
Sensitization to inhaled ryegrass pollen by collateral priming in a murine model of allergic respiratory disease.
    International archives of allergy and immunology, 2010, Volume: 152, Issue:3

    Topics: Airway Resistance; Animals; Antigens, Plant; Blotting, Western; Bronchial Hyperreactivity; Bronchial Provocation Tests; Disease Models, Animal; Gene Expression; Immunization; Immunoglobulin E; Immunoglobulin G; Inflammation; Interleukin-13; Interleukin-4; Interleukin-5; Lolium; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Plant Extracts; Plant Proteins; Pollen; Respiratory Hypersensitivity; Th2 Cells

2010
Precapillary pulmonary hypertension leads to reversible bronchial hyperreactivity in rats.
    Experimental lung research, 2010, Volume: 36, Issue:3

    Topics: Airway Resistance; Animals; Aorta, Abdominal; Blood Pressure; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Disease Models, Animal; Hypertension, Pulmonary; Male; Methacholine Chloride; Models, Biological; Oscillometry; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Respiratory Mechanics; Time Factors; Vena Cava, Inferior

2010
Ammonium persulfate can initiate an asthmatic response in mice.
    Thorax, 2010, Volume: 65, Issue:3

    Topics: Ammonium Sulfate; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cell Proliferation; Cells, Cultured; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Immunoglobulin E; Lymph Nodes; Lymphocyte Activation; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C

2010
Reversal of methylprednisolone effects in allergen-exposed female BALB/c mice.
    Journal of toxicology and environmental health. Part A, 2010, Volume: 73, Issue:11

    Topics: Administration, Intranasal; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cyclosporine; Disease Models, Animal; Drug Antagonism; Female; Glucocorticoids; Immunosuppressive Agents; Injections, Intraperitoneal; Lung; Methacholine Chloride; Methylprednisolone; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Function Tests; Respiratory Hypersensitivity

2010
Ozone increases airway hyperreactivity and mucus hyperproduction in mice previously exposed to allergen.
    Journal of toxicology and environmental health. Part A, 2010, Volume: 73, Issue:11

    Topics: Air Pollutants; Allergens; Animals; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Interactions; Inhalation Exposure; Leukocyte Count; Leukocytes; Lung; Methacholine Chloride; Mice; Mucus; Ovalbumin; Ozone; Periodic Acid-Schiff Reaction; Respiratory Function Tests

2010
Airway inflammation and remodeling in two mouse models of asthma: comparison of males and females.
    International archives of allergy and immunology, 2010, Volume: 153, Issue:2

    Topics: Airway Remodeling; Animals; Asthma; Cytokines; Disease Models, Animal; Eosinophils; Female; Immunoglobulin E; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Pyroglyphidae; Sex Characteristics

2010
Alveolar macrophages reduce airway hyperresponsiveness and modulate cytokine levels.
    Experimental lung research, 2010, Volume: 36, Issue:5

    Topics: Allergens; Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cytokines; Disease Models, Animal; Interleukins; Macrophages, Alveolar; Male; Methacholine Chloride; Ovalbumin; Rats; Rats, Inbred BN; Rats, Sprague-Dawley; Time Factors; Tumor Necrosis Factor-alpha

2010
Thalidomide attenuates airway hyperresponsiveness and eosinophilic inflammation in a murine model of allergic asthma.
    Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Female; Goblet Cells; Hyperplasia; Inflammation; Interleukin-5; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Thalidomide; Tumor Necrosis Factor-alpha

2010
Concomitant administration of nitric oxide and glucocorticoids improves protection against bronchoconstriction in a murine model of asthma.
    Journal of applied physiology (Bethesda, Md. : 1985), 2010, Volume: 109, Issue:2

    Topics: Administration, Inhalation; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cyclic GMP; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Female; Glucocorticoids; Guanylate Cyclase; Hydrazines; Hydrocortisone; Injections, Intraperitoneal; Lipopolysaccharides; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Ovalbumin; Oxadiazoles; Pneumonia; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Receptors, Glucocorticoid; Respiration, Artificial; Respiratory Mechanics; Soluble Guanylyl Cyclase

2010
Combined forced oscillation and forced expiration measurements in mice for the assessment of airway hyperresponsiveness.
    Respiratory research, 2010, Jun-21, Volume: 11

    Topics: Adrenal Cortex Hormones; Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Dexamethasone; Disease Models, Animal; Female; Forced Expiratory Flow Rates; Forced Expiratory Volume; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Oscillometry; Ovalbumin; Respiratory Function Tests; Respiratory Mechanics; Time Factors; Vital Capacity

2010
Fractionation of swine barn dust and assessment of its impact on the respiratory tract following repeated airway exposure.
    Journal of toxicology and environmental health. Part A, 2010, Volume: 73, Issue:16

    Topics: Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chemokines; Cytokines; Disease Models, Animal; Dust; Enzyme-Linked Immunosorbent Assay; Housing, Animal; Inflammation; Inhalation Exposure; Interleukin-1beta; Interleukin-6; Methacholine Chloride; Mice; Plethysmography; Respiratory System; Risk Assessment; Swine; Time Factors; Tumor Necrosis Factor-alpha

2010
A comparison of the allergic responses induced by Penicillium chrysogenum and house dust mite extracts in a mouse model.
    Indoor air, 2010, Volume: 20, Issue:5

    Topics: Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dose-Response Relationship, Immunologic; Hypersensitivity; Immunoglobulin E; Intubation, Intratracheal; L-Lactate Dehydrogenase; Methacholine Chloride; Mice; Mice, Inbred BALB C; Penicillium chrysogenum; Pyroglyphidae

2010
IL-12-STAT4-IFN-gamma axis is a key downstream pathway in the development of IL-13-mediated asthma phenotypes in a Th2 type asthma model.
    Experimental & molecular medicine, 2010, Aug-31, Volume: 42, Issue:8

    Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Interferon-gamma; Interleukin-12; Interleukin-12 Receptor beta 2 Subunit; Interleukin-13; Interleukin-4; Methacholine Chloride; Mice; Mice, Transgenic; Models, Immunological; Organ Specificity; Pneumonia; Receptors, Cell Surface; Signal Transduction; STAT4 Transcription Factor; Th2 Cells

2010
Sex-specific lung remodeling and inflammation changes in experimental allergic asthma.
    Journal of applied physiology (Bethesda, Md. : 1985), 2010, Volume: 109, Issue:3

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Chronic Disease; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Matrix; Female; Inflammation Mediators; Interleukin-4; Interleukin-5; Lung; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Ovariectomy; Pneumonia; Sex Factors; Time Factors; Transforming Growth Factor beta

2010
No role for neutrophil elastase in influenza-induced cellular recruitment, cytokine production or airway hyperresponsiveness in mice.
    Respiratory physiology & neurobiology, 2010, Sep-30, Volume: 173, Issue:2

    Topics: Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Chemokine CXCL2; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Leukocyte Elastase; Lung; Methacholine Chloride; Mice; Mice, Knockout; Orthomyxoviridae Infections; Statistics, Nonparametric; Tumor Necrosis Factor-alpha

2010
Comprehensive analysis of elastase-induced pulmonary emphysema in mice: effects of ambient existing particulate matters.
    International immunopharmacology, 2010, Volume: 10, Issue:11

    Topics: Alkaline Phosphatase; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Hydro-Lyases; Interleukin-1beta; Lymphocytes; Macrophages; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Pancreatic Elastase; Particulate Matter; Pneumonia; Pulmonary Emphysema; Swine; Vehicle Emissions

2010
Proteome analysis of multiple compartments in a mouse model of chemical-induced asthma.
    Journal of proteome research, 2010, Nov-05, Volume: 9, Issue:11

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Inflammation; Mass Spectrometry; Methacholine Chloride; Mice; Neutrophils; Oxidative Stress; Proteome; Toluene 2,4-Diisocyanate

2010
Successful transfer of chemical-induced asthma by adoptive transfer of low amounts of lymphocytes in a mouse model.
    Toxicology, 2011, Jan-11, Volume: 279, Issue:1-3

    Topics: Adoptive Transfer; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Immunoglobulin E; Lymphocytes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Time Factors; Toluene 2,4-Diisocyanate

2011
Effects of oral monosodium glutamate in mouse models of asthma.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2011, Volume: 49, Issue:1

    Topics: Administration, Oral; Animals; Asthma; Body Weight; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Eosinophils; Immunoglobulin E; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Sodium Glutamate; Trachea

2011
The effects of inhaled house dust mite on airway barrier function and sensitivity to inhaled methacholine in mice.
    American journal of physiology. Lung cellular and molecular physiology, 2011, Volume: 300, Issue:2

    Topics: Administration, Inhalation; Allergens; Animals; Antigens, Dermatophagoides; Dermatophagoides pteronyssinus; Disease Models, Animal; Female; Humans; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Models, Biological; Radiopharmaceuticals; Respiratory Hypersensitivity; Respiratory Mechanics; Technetium Tc 99m Pentetate; Tomography, Emission-Computed, Single-Photon

2011
Reduced methacholine-induced submandibular salivary secretion in rats with experimental periodontitis.
    Archives of oral biology, 2011, Volume: 56, Issue:5

    Topics: Animals; Dinoprostone; Disease Models, Animal; Male; Methacholine Chloride; Nitric Oxide Synthase Type II; Periodontitis; Random Allocation; Rats; Rats, Wistar; Saliva; Salivation; Submandibular Gland

2011
Toll-like receptor 2 regulates organic dust-induced airway inflammation.
    American journal of respiratory cell and molecular biology, 2011, Volume: 45, Issue:4

    Topics: Animal Husbandry; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Chemokines; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Dust; Housing, Animal; Inflammation Mediators; Inhalation Exposure; Lipopolysaccharides; Lung; Macrophages, Alveolar; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; Neutrophils; Nitric Oxide; Peptidoglycan; Pneumonia; Swine; Time Factors; Toll-Like Receptor 2

2011
Hesperidin suppresses ovalbumin-induced airway inflammation in a mouse allergic asthma model.
    Inflammation, 2012, Volume: 35, Issue:1

    Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Hesperidin; Immunoglobulin E; Inflammation; Interleukin-13; Interleukin-4; Interleukin-5; Leukocytes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory System; Th2 Cells

2012
Strain-dependent genomic factors affect allergen-induced airway hyperresponsiveness in mice.
    American journal of respiratory cell and molecular biology, 2011, Volume: 45, Issue:4

    Topics: Airway Resistance; Allergens; Animals; Antigens, Dermatophagoides; Arthropod Proteins; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cysteine Endopeptidases; Cytokines; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Genetic Predisposition to Disease; Immunoglobulin E; Immunoglobulin G; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mucins; Phenotype; Receptors, G-Protein-Coupled; Th2 Cells; Time Factors

2011
ICOS ligand expression is essential for allergic airway hyperresponsiveness.
    International immunology, 2011, Volume: 23, Issue:4

    Topics: Animals; Bronchial Hyperreactivity; Cells, Cultured; Cytokines; Disease Models, Animal; Female; Humans; Immunity, Humoral; Immunization; Immunoglobulin E; Inducible T-Cell Co-Stimulator Ligand; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovalbumin; Proteins; Respiratory Hypersensitivity; Th17 Cells

2011
Molecular model of naphthalene-induced DNA damage in the murine lung.
    Human & experimental toxicology, 2012, Volume: 31, Issue:1

    Topics: Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; DNA Breaks, Double-Stranded; Epithelial Cells; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mutagens; Naphthalenes

2012
A single DH gene segment is sufficient for the establishment of an asthma phenotype in a murine model of allergic airway inflammation.
    International archives of allergy and immunology, 2011, Volume: 156, Issue:3

    Topics: Allergens; Animals; Asthma; B-Lymphocytes; Bronchial Hyperreactivity; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hypersensitivity; Immunoglobulin E; Immunoglobulin G; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Ovalbumin

2011
Effects of furosemide on allergic asthmatic responses in mice.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2011, Volume: 41, Issue:10

    Topics: Allergens; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Furosemide; Goblet Cells; Hypersensitivity; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; T-Lymphocytes; Treatment Outcome

2011
Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma.
    The Journal of clinical investigation, 2011, Volume: 121, Issue:8

    Topics: Animals; Asthma; Bronchoalveolar Lavage; Chemokines; Disease Models, Animal; Gene Expression Regulation; Inflammation; Interferon-gamma; Lung; Mast Cells; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Biological; Oligonucleotide Array Sequence Analysis; Th1 Cells; Th2 Cells

2011
S-nitrosoglutathione supplementation to ovalbumin-sensitized and -challenged mice ameliorates methacholine-induced bronchoconstriction.
    American journal of physiology. Lung cellular and molecular physiology, 2011, Volume: 301, Issue:5

    Topics: Administration, Inhalation; Aerosols; Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Inflammation; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mucin 5AC; Ovalbumin; S-Nitrosoglutathione; Tracheotomy

2011
Capsicum annuum L. methanolic extract inhibits ovalbumin-induced airway inflammation and oxidative stress in a mouse model of asthma.
    Journal of medicinal food, 2011, Volume: 14, Issue:10

    Topics: Administration, Oral; Animals; Antioxidants; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Capsicum; Cytokines; Disease Models, Animal; Female; Fruit; Immunoglobulin E; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; NF-kappa B; Ovalbumin; Oxidative Stress; Plant Extracts; Reactive Oxygen Species; T-Lymphocytes, Helper-Inducer

2011
Iron administration reduces airway hyperreactivity and eosinophilia in a mouse model of allergic asthma.
    Clinical and experimental immunology, 2011, Volume: 166, Issue:1

    Topics: Allergens; Animals; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eosinophilia; Humans; Immunoglobulin E; Infant; Injections, Intraperitoneal; Iron; Iron-Dextran Complex; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phenanthrolines; Plethysmography

2011
Effects of experimental asthma on inflammation and lung mechanics in sickle cell mice.
    American journal of respiratory cell and molecular biology, 2012, Volume: 46, Issue:3

    Topics: Airway Resistance; Anemia, Sickle Cell; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Colorimetry; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eosinophils; Hemoglobin A; Hemoglobin, Sickle; Humans; Immunoglobulin E; Inflammation Mediators; L-Lactate Dehydrogenase; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ovalbumin; Pneumonia; Positive-Pressure Respiration; Vascular Endothelial Growth Factor A

2012
Effects of simulated downwind coal combustion emissions on pre-existing allergic airway responses in mice.
    Inhalation toxicology, 2011, Volume: 23, Issue:13

    Topics: Air Pollutants; Animals; Antibodies; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Coal; Cytokines; Disease Models, Animal; Eosinophils; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; Particulate Matter; Pneumonia; Power Plants; Respiratory Hypersensitivity

2011
Effects of maternal food restriction on offspring lung extracellular matrix deposition and long term pulmonary function in an experimental rat model.
    Pediatric pulmonology, 2012, Volume: 47, Issue:2

    Topics: Actins; Animals; Animals, Newborn; Caloric Restriction; Disease Models, Animal; Elastin; Extracellular Matrix; Female; Fetal Growth Retardation; Lung; Methacholine Chloride; Pregnancy; Prenatal Nutritional Physiological Phenomena; Rats; Rats, Sprague-Dawley

2012
Inhibition of Pim1 kinase activation attenuates allergen-induced airway hyperresponsiveness and inflammation.
    American journal of respiratory cell and molecular biology, 2012, Volume: 46, Issue:4

    Topics: Allergens; Animals; Bronchoalveolar Lavage Fluid; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Female; Goblet Cells; Hypersensitivity; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Pneumonia; Proto-Oncogene Proteins c-pim-1; Respiratory Hypersensitivity

2012
Hypertrophic airway smooth muscle mass correlates with increased airway responsiveness in a murine model of asthma.
    American journal of respiratory cell and molecular biology, 2012, Volume: 46, Issue:4

    Topics: Airway Resistance; Animals; Apoptosis; Asthma; Cell Proliferation; Disease Models, Animal; Female; Hypertrophy; Methacholine Chloride; Mice; Mice, Inbred BALB C; Muscle, Smooth; Ovalbumin; Respiratory Hypersensitivity

2012
Assessment of peripheral airway function following chronic allergen challenge in a sheep model of asthma.
    PloS one, 2011, Volume: 6, Issue:12

    Topics: Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Separation; Chronic Disease; Disease Models, Animal; Eosinophils; Female; Lung; Methacholine Chloride; Pyroglyphidae; Sheep

2011
Effects of corticosteroid treatment on airway inflammation, mechanics, and hyperpolarized ³He magnetic resonance imaging in an allergic mouse model.
    Journal of applied physiology (Bethesda, Md. : 1985), 2012, Volume: 112, Issue:9

    Topics: Adrenal Cortex Hormones; Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchoconstrictor Agents; Dexamethasone; Disease Models, Animal; Elasticity; Helium; Hypersensitivity; Isotopes; Lung; Magnetic Resonance Imaging; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Models, Biological; Ovalbumin; Pulmonary Ventilation; Respiratory Mechanics

2012
Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB.
    European journal of pharmacology, 2012, Mar-15, Volume: 679, Issue:1-3

    Topics: Airway Resistance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Adhesion Molecules; Cell Count; Chemokines; Chitinases; Cytokines; Disease Models, Animal; DNA-Binding Proteins; Dose-Response Relationship, Drug; Female; Flavonoids; Flavonols; Genes, Reporter; Inflammation; Inflammation Mediators; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucin 5AC; Mucus; NF-kappa B; Nitric Oxide Synthase Type II; Ovalbumin; Protein Transport; Tumor Necrosis Factor-alpha

2012
Chloride secretion by cultures of pig tracheal gland cells.
    American journal of physiology. Lung cellular and molecular physiology, 2012, May-15, Volume: 302, Issue:10

    Topics: Amiloride; Animals; Biomarkers; Calcium; Cells, Cultured; Chlorides; Cyclic AMP; Cystic Fibrosis; Diffusion Chambers, Culture; Disease Models, Animal; Electric Impedance; Epithelial Cells; Exocrine Glands; Humans; Ion Transport; Lactoferrin; Methacholine Chloride; Mucin-5B; Muramidase; Swine; Tight Junctions; Trachea

2012
Airway responsiveness depends on the diffusion rate of methacholine across the airway wall.
    Journal of applied physiology (Bethesda, Md. : 1985), 2012, Volume: 112, Issue:10

    Topics: Administration, Inhalation; Aerosols; Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Computer Simulation; Diffusion; Disease Models, Animal; Dose-Response Relationship, Drug; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Models, Biological; Muscle, Smooth; Ovalbumin; Permeability

2012
IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction.
    Nature medicine, 2012, Mar-04, Volume: 18, Issue:4

    Topics: Analysis of Variance; Animals; Asthma; CD11c Antigen; CD4 Antigens; Dendritic Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Humans; In Vitro Techniques; Integrin alphaV; Interleukin-17; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Ovalbumin; Potassium Chloride; Respiratory System; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Th17 Cells

2012
Discovery of a novel orally active PDE-4 inhibitor effective in an ovalbumin-induced asthma murine model.
    European journal of pharmacology, 2012, Jun-15, Volume: 685, Issue:1-3

    Topics: Administration, Oral; Animals; Anti-Asthmatic Agents; Asthma; Benzoates; Bronchial Hyperreactivity; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophil Peroxidase; Female; Ferrets; Guinea Pigs; Inhibitory Concentration 50; Lipopolysaccharides; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phosphodiesterase 4 Inhibitors; Pyrazoles; Rats; Rats, Sprague-Dawley

2012
Bronchoprotection in conscious guinea pigs by budesonide and the NO-donating analogue, TPI 1020, alone and combined with tiotropium or formoterol.
    British journal of pharmacology, 2012, Volume: 167, Issue:3

    Topics: Administration, Inhalation; Animals; Bronchoconstriction; Bronchodilator Agents; Budesonide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethanolamines; Formoterol Fumarate; Guinea Pigs; Histamine; Male; Methacholine Chloride; Respiratory Tract Diseases; Scopolamine Derivatives; Time Factors; Tiotropium Bromide

2012
Corticosteroid treatment inhibits airway hyperresponsiveness and lung injury in a murine model of chemical-induced airway inflammation.
    Toxicology, 2012, Nov-15, Volume: 301, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Collagen; Dexamethasone; Disease Models, Animal; Female; Glucocorticoids; Inflammation; Lung; Lung Injury; Macrophages; Melphalan; Methacholine Chloride; Mice; Mice, Inbred C57BL; Neutrophils; Time Factors

2012
Protein kinase C epsilon is important in modulating organic-dust-induced airway inflammation.
    Experimental lung research, 2012, Volume: 38, Issue:8

    Topics: Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Chemokines; Disease Models, Animal; Dust; Environmental Exposure; Enzyme Activation; Female; Inflammation Mediators; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; Protein Kinase C-epsilon; T-Lymphocytes

2012
Caveolin-1 knockout mice exhibit airway hyperreactivity.
    American journal of physiology. Lung cellular and molecular physiology, 2012, Oct-15, Volume: 303, Issue:8

    Topics: Animals; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Calcium; Caveolin 1; Disease Models, Animal; Methacholine Chloride; Mice; Mice, Inbred Strains; Mice, Knockout; Muscle, Smooth; Ovalbumin; Receptors, Cell Surface; Receptors, Tumor Necrosis Factor, Type I; Respiratory Mucosa

2012
Spleen tyrosine kinase inhibition attenuates airway hyperresponsiveness and pollution-induced enhanced airway response in a chronic mouse model of asthma.
    The Journal of allergy and clinical immunology, 2013, Volume: 131, Issue:2

    Topics: Air Pollutants; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cells, Cultured; Disease Models, Animal; Female; Humans; Inflammation; Intracellular Signaling Peptides and Proteins; Keratinocytes; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Respiratory Mucosa; Syk Kinase; Vascular Endothelial Growth Factor A

2013
Variation in airway responsiveness of male C57BL/6 mice from 5 vendors.
    Journal of the American Association for Laboratory Animal Science : JAALAS, 2012, Volume: 51, Issue:4

    Topics: Airway Resistance; Animal Feed; Animals; Animals, Laboratory; Asthma; Breeding; Bronchoconstrictor Agents; Commerce; Disease Models, Animal; Environment; Genetic Variation; Housing, Animal; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Species Specificity

2012
Effect of the fungal immunomodulatory protein FIP-fve on airway inflammation and cytokine production in mouse asthma model.
    Cytokine, 2013, Volume: 61, Issue:1

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Fungal Proteins; Inflammation; Inflammation Mediators; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory System; Th1 Cells; Th2 Cells

2013
CD4+CD25+Foxp3+ T cells contribute to the antiasthmatic effects of Astragalus membranaceus extract in a rat model of asthma.
    International immunopharmacology, 2013, Volume: 15, Issue:1

    Topics: Animals; Anti-Asthmatic Agents; Asthma; Astragalus propinquus; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Forkhead Transcription Factors; Male; Methacholine Chloride; Ovalbumin; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; RNA, Messenger; T-Lymphocytes, Regulatory

2013
Prevention of airway hyperresponsiveness induced by left ventricular dysfunction in rats.
    Respiratory research, 2012, Dec-13, Volume: 13

    Topics: Airway Resistance; Angiotensin-Converting Enzyme Inhibitors; Animals; Arterial Pressure; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Calcium Channel Blockers; Disease Models, Animal; Diuretics; Drug Therapy, Combination; Hypertension, Pulmonary; Lung; Lung Volume Measurements; Male; Methacholine Chloride; Myocardial Ischemia; Plethysmography; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Time Factors; Ventricular Dysfunction, Left; Ventricular Function, Left

2012
Latex sensitization by dermal exposure can lead to airway hyperreactivity.
    International archives of allergy and immunology, 2002, Volume: 128, Issue:3

    Topics: Administration, Cutaneous; Allergens; Animals; Bronchial Hyperreactivity; Disease Models, Animal; Female; Gloves, Protective; Immunoglobulin E; Latex; Latex Hypersensitivity; Methacholine Chloride; Mice; Mice, Inbred BALB C; Proteins

2002
Interleukin-1beta-induced airway hyperresponsiveness enhances substance P in intrinsic neurons of ferret airway.
    American journal of physiology. Lung cellular and molecular physiology, 2002, Volume: 283, Issue:5

    Topics: Acetylcholine; Animals; Bronchial Hyperreactivity; Disease Models, Animal; Electric Stimulation; Ferrets; Instillation, Drug; Interleukin-1; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Neurons; Substance P; Trachea

2002
Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice.
    American journal of physiology. Lung cellular and molecular physiology, 2002, Volume: 283, Issue:5

    Topics: Animals; Antigens; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Calcitonin Gene-Related Peptide; Crosses, Genetic; Disease Models, Animal; DNA; Female; Genomic Library; Genotype; Immunohistochemistry; Leukocyte Count; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovalbumin

2002
Reduction of the internal atrial defibrillation threshold with balanced orthogonal sequential shocks.
    Journal of cardiovascular electrophysiology, 2002, Volume: 13, Issue:9

    Topics: Animals; Atrial Fibrillation; Defibrillators, Implantable; Differential Threshold; Disease Models, Animal; Electric Countershock; Electric Impedance; Electrodes, Implanted; Heart Atria; Heart Conduction System; Methacholine Chloride; Models, Cardiovascular; Parasympathomimetics; Sheep; Treatment Outcome; Vena Cava, Superior

2002
Antiinflammatory effects of genistein, a tyrosine kinase inhibitor, on a guinea pig model of asthma.
    American journal of respiratory and critical care medicine, 2003, Jan-15, Volume: 167, Issue:2

    Topics: Analysis of Variance; Animals; Asthma; Blotting, Western; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Dexamethasone; Disease Models, Animal; Enzyme Inhibitors; Genistein; Guinea Pigs; Immunohistochemistry; Injections, Intraperitoneal; Male; Methacholine Chloride; Probability; Random Allocation; Reference Values; Trachea; Treatment Outcome

2003
Disruption of L-histidine decarboxylase reduces airway eosinophilia but not hyperresponsiveness.
    American journal of respiratory and critical care medicine, 2003, Mar-01, Volume: 167, Issue:5

    Topics: Administration, Inhalation; Airway Resistance; Animals; Asthma; Bone Marrow Cells; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eosinophilia; Eosinophils; Histamine; Histidine Decarboxylase; Immunoblotting; Interleukin-5; Leukocyte Count; Lung; Male; Methacholine Chloride; Mice; Mice, Knockout; Ovalbumin; Pulmonary Eosinophilia; Selectins; Time Factors

2003
An improved porcine model of stable methacholine-induced bronchospasm.
    Intensive care medicine, 2003, Volume: 29, Issue:1

    Topics: Animals; Asthma; Bronchial Spasm; Disease Models, Animal; Methacholine Chloride; Reproducibility of Results; Respiration, Artificial; Respiratory Mechanics; Swine; Ventilation-Perfusion Ratio

2003
A broad-spectrum caspase inhibitor attenuates allergic airway inflammation in murine asthma model.
    Journal of immunology (Baltimore, Md. : 1950), 2003, Mar-15, Volume: 170, Issue:6

    Topics: Aerosols; Allergens; Amino Acid Chloromethyl Ketones; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Caspase Inhibitors; Cell Movement; Cysteine Proteinase Inhibitors; Disease Models, Animal; Inflammation; Interleukin-4; Interleukin-5; Intubation, Intratracheal; Leukocytes; Lung; Lymphocyte Activation; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; T-Lymphocytes

2003
The role of L-carnitine in treatment of a murine model of asthma.
    Acta medica Okayama, 2002, Volume: 56, Issue:6

    Topics: Animals; Asthma; Carnitine; Disease Models, Animal; Leukotriene E4; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Oxygen

2002
Chlorine-induced injury to the airways in mice.
    American journal of respiratory and critical care medicine, 2003, Sep-01, Volume: 168, Issue:5

    Topics: Administration, Inhalation; Animals; Asthma; Bronchoconstrictor Agents; Chemical Warfare Agents; Chlorine; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Methacholine Chloride; Mice; Respiratory System; Severity of Illness Index; Time Factors

2003
Effects of helium-oxygen on respiratory mechanics, gas exchange, and ventilation-perfusion relationships in a porcine model of stable methacholine-induced bronchospasm.
    Intensive care medicine, 2003, Volume: 29, Issue:9

    Topics: Acute Disease; Animals; Asthma; Bronchial Spasm; Bronchoconstrictor Agents; Disease Models, Animal; Helium; Methacholine Chloride; Oxygen Inhalation Therapy; Pulmonary Gas Exchange; Respiration, Artificial; Respiratory Mechanics; Swine; Treatment Outcome; Ventilation-Perfusion Ratio

2003
Mycobacterium vaccae administration during allergen sensitization or challenge suppresses asthmatic features.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2003, Volume: 33, Issue:8

    Topics: Allergens; Animals; Asthma; Bacterial Vaccines; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; Immunoglobulins; Leukocyte Count; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mycobacterium; Ovalbumin; Pulmonary Eosinophilia

2003
Airway eosinophil accumulation on sensory neuropeptide release in a guinea pig model of distilled-water-induced bronchoconstriction.
    Journal of investigational allergology & clinical immunology, 2003, Volume: 13, Issue:2

    Topics: Aerosols; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Disease Models, Animal; Eosinophils; Guinea Pigs; Immunization, Passive; Male; Methacholine Chloride; Piperidines; Platelet Activating Factor; Quinuclidines; Substance P; Water

2003
Effects of fexofenadine on T-cell function in a murine model of allergen-induced airway inflammation and hyperresponsiveness.
    The Journal of allergy and clinical immunology, 2003, Volume: 112, Issue:4 Suppl

    Topics: Administration, Inhalation; Adoptive Transfer; Allergens; Animals; Anti-Allergic Agents; Antibody Specificity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Female; Histamine H1 Antagonists; Immunoglobulin E; Injections, Intraperitoneal; Leukocyte Count; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Hypersensitivity; Rhinitis, Allergic, Perennial; T-Lymphocytes; Terfenadine; Time Factors; Treatment Outcome

2003
Accumulation of peribronchial mast cells in a mouse model of ovalbumin allergen induced chronic airway inflammation: modulation by immunostimulatory DNA sequences.
    Journal of immunology (Baltimore, Md. : 1950), 2003, Nov-01, Volume: 171, Issue:9

    Topics: Adjuvants, Immunologic; Administration, Intranasal; Allergens; Animals; Bone Marrow Cells; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cell Aggregation; Cell Count; Cell Division; Chronic Disease; CpG Islands; Disease Models, Animal; DNA; DNA-Binding Proteins; Drug Administration Schedule; Female; Fluorescent Dyes; Growth Inhibitors; Immunoglobulin E; Inflammation; Injections, Subcutaneous; Interleukin-4; Interleukin-9; Lung; Mast Cells; Methacholine Chloride; Mice; Mice, Inbred BALB C; Oligodeoxyribonucleotides; Ovalbumin; Receptors, Cell Surface; Rhodamines; Toll-Like Receptor 9

2003
Recall helper T cell response: T helper 1 cell-resistant allergic susceptibility without biasing uncommitted CD4 T cells.
    American journal of respiratory and critical care medicine, 2004, Mar-01, Volume: 169, Issue:5

    Topics: Animals; Antigens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; CD4 Antigens; CD4-Positive T-Lymphocytes; Disease Models, Animal; Eosinophils; Female; Flow Cytometry; Genetic Predisposition to Disease; Hypersensitivity, Immediate; Immune Tolerance; Inflammation; Methacholine Chloride; Mice; Mice, Inbred BALB C; Receptors, Interleukin-2; Th1 Cells; Th2 Cells

2004
Site of inflammation influences site of hyperresponsiveness in experimental asthma.
    Respiratory physiology & neurobiology, 2003, Dec-16, Volume: 139, Issue:1

    Topics: Aerosols; Animals; Asthma; Bronchi; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Inflammation; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Function Tests; Respiratory Hypersensitivity; Time Factors; Vascular Resistance

2003
Airway responsiveness after acute exposure to urban particulate matter 1648 in a DO11.10 murine model.
    American journal of physiology. Lung cellular and molecular physiology, 2004, Volume: 286, Issue:2

    Topics: Air Pollutants; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Transgenic; Ovalbumin; Respiratory Hypersensitivity

2004
Airway hyperresponsiveness to bradykinin induced by allergen challenge in actively sensitised Brown Norway rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 2004, Volume: 369, Issue:2

    Topics: Adenosine; Adrenergic beta-1 Receptor Agonists; Adrenergic beta-2 Receptor Antagonists; Animals; Arachidonate 5-Lipoxygenase; Bradykinin; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Endopeptidases; Lung; Male; Mast Cells; Methacholine Chloride; Ovalbumin; Rats; Rats, Inbred BN; Receptors, Muscarinic; Tachykinins

2004
Adoptive transfer of alveolar macrophages abrogates bronchial hyperresponsiveness.
    American journal of respiratory cell and molecular biology, 2004, Volume: 31, Issue:1

    Topics: Adoptive Transfer; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Clodronic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Genetic Predisposition to Disease; Immunoglobulin E; Immunoglobulin G; Liposomes; Macrophages, Alveolar; Male; Methacholine Chloride; Ovalbumin; Rats; Rats, Sprague-Dawley; Reaction Time

2004
Ozone-induced acute pulmonary injury in inbred mouse strains.
    American journal of respiratory cell and molecular biology, 2004, Volume: 31, Issue:1

    Topics: Acute Disease; Animals; Bronchoalveolar Lavage Fluid; Cell Division; Chemotaxis, Leukocyte; Chromosome Mapping; Disease Models, Animal; Drug Resistance; Genetic Predisposition to Disease; Interleukin-6; Lung; Lung Diseases; Lymphocytes; Male; Methacholine Chloride; Mice; Mice, Inbred Strains; Neutrophils; Ozone; Phenotype; Plethysmography; Respiratory Mucosa; Species Specificity

2004
(S,S)-formoterol increases the production of IL-4 in mast cells and the airways of a murine asthma model.
    International archives of allergy and immunology, 2004, Volume: 133, Issue:4

    Topics: Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Disease Models, Animal; Ethanolamines; Formoterol Fumarate; Histamine Release; Histocytochemistry; Humans; Interleukin-4; Jurkat Cells; Lung; Male; Mast Cells; Methacholine Chloride; Mice; Mice, Inbred BALB C; Prostaglandin D2; Stereoisomerism; T-Lymphocytes

2004
Aerosolized anti-T-cell-receptor antibodies are effective against airway inflammation and hyperreactivity.
    International archives of allergy and immunology, 2004, Volume: 134, Issue:1

    Topics: Administration, Inhalation; Airway Resistance; Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibody Specificity; Bronchial Hyperreactivity; Bronchitis; Disease Models, Animal; Dose-Response Relationship, Drug; Flow Cytometry; Lung; Lymphocyte Count; Lymphocyte Depletion; Methacholine Chloride; Mice; Mice, Inbred C57BL; Ovalbumin; Receptors, Antigen, T-Cell; Receptors, Antigen, T-Cell, gamma-delta; Respiratory Hypersensitivity; T-Lymphocyte Subsets

2004
Increased tracheal responsiveness to beta-adrenergic agonist and antagonist in ovalbumin-sensitized guinea pigs.
    Pharmacology, 2004, Volume: 71, Issue:2

    Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aerosols; Animals; Bronchial Hyperreactivity; Disease Models, Animal; Guinea Pigs; Immunization; Injections, Intraperitoneal; Injections, Subcutaneous; Isoproterenol; Male; Methacholine Chloride; Ovalbumin; Propranolol; Trachea

2004
Respiratory response to toluene diisocyanate depends on prior frequency and concentration of dermal sensitization in mice.
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 80, Issue:2

    Topics: Administration, Intranasal; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Dermatitis, Allergic Contact; Disease Models, Animal; Immunoglobulin E; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Occupational Exposure; Plethysmography, Whole Body; Respiratory Mechanics; Toluene 2,4-Diisocyanate

2004
Greater involvement of neurokinins found in Guinea pig models of severe asthma compared with mild asthma.
    International archives of allergy and immunology, 2004, Volume: 134, Issue:4

    Topics: Administration, Inhalation; Airway Resistance; Allergens; Animals; Asthma; Biomarkers; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Capsaicin; Disease Models, Animal; Eosinophils; Guinea Pigs; Lung; Male; Methacholine Chloride; Neprilysin; Neurokinin A; Respiratory Hypersensitivity; Severity of Illness Index; Substance P

2004
Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness.
    Nature medicine, 2004, Volume: 10, Issue:8

    Topics: Adoptive Transfer; Allergens; Alum Compounds; Analysis of Variance; Animals; Bronchial Hyperreactivity; Bronchitis; Bronchoalveolar Lavage Fluid; CD8 Antigens; CD8-Positive T-Lymphocytes; Cells, Cultured; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Interleukin-13; Lung; Methacholine Chloride; Mice; Mice, Mutant Strains; Ovalbumin; T-Lymphocyte Subsets

2004
Involvement of enhanced neurokinin NK3 receptor expression in the severe asthma guinea pig model.
    European journal of pharmacology, 2004, Sep-13, Volume: 498, Issue:1-3

    Topics: Animals; Asthma; Benzamides; Binding, Competitive; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Lung; Male; Methacholine Chloride; Neurokinin B; Ovalbumin; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Substance P; Tritium

2004
Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma.
    Immunology, 2004, Volume: 113, Issue:2

    Topics: Animals; Asthma; B-Lymphocytes; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Complement C5a; Disease Models, Animal; Female; Haptens; Immunization; Immunoglobulin M; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Respiratory Function Tests; Respiratory System

2004
The pattern of methacholine responsiveness in mice is dependent on antigen challenge dose.
    Respiratory research, 2004, Sep-23, Volume: 5

    Topics: Animals; Antigens; Bronchi; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Disease Models, Animal; Female; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin

2004
Para-Bromophenacyl bromide alleviates airway hyperresponsiveness and modulates cytokines, IgE and eosinophil levels in ovalbumin-sensitized and -challenged mice.
    International immunopharmacology, 2004, Dec-15, Volume: 4, Issue:13

    Topics: Acetophenones; Administration, Inhalation; Aerosols; Airway Obstruction; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Eosinophils; Immunization; Immunoglobulin E; India; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phospholipases A

2004
Effect of leptin on allergic airway responses in mice.
    The Journal of allergy and clinical immunology, 2005, Volume: 115, Issue:1

    Topics: Administration, Cutaneous; Allergens; Animals; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Immunoglobulin E; Infusion Pumps, Implantable; Leptin; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Hypersensitivity; RNA, Messenger

2005
A guinea pig model for cough variant asthma and role of tachykinins.
    Experimental lung research, 2004, Volume: 30, Issue:8

    Topics: Airway Resistance; Allergens; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Cough; Disease Models, Animal; Guinea Pigs; Male; Methacholine Chloride; Ovalbumin; Peptides, Cyclic; Procaterol; Tachykinins

2004
PPAR-gamma modulates allergic inflammation through up-regulation of PTEN.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:8

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Female; Gene Expression; Gene Expression Regulation; Interleukin-13; Interleukin-4; Interleukin-5; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phosphatidylinositol 3-Kinases; Phosphorylation; Pioglitazone; PPAR gamma; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; Rosiglitazone; Thiazolidinediones; Trachea; Transfection

2005
Activation sequences following failed atrial defibrillation.
    Heart rhythm, 2004, Volume: 1, Issue:5

    Topics: Animals; Atrial Fibrillation; Disease Models, Animal; Electric Countershock; Electrodes; Electrophysiologic Techniques, Cardiac; Female; Heart Atria; Male; Methacholine Chloride; Parasympathomimetics; Sheep

2004
Antianginal effects of lercanidipine on the vasopressin or methacholine induced anginal model in rats.
    Biological & pharmaceutical bulletin, 2005, Volume: 28, Issue:5

    Topics: Angina Pectoris; Animals; Dihydropyridines; Disease Models, Animal; Male; Methacholine Chloride; Rats; Rats, Sprague-Dawley; Vasodilator Agents; Vasopressins

2005
Effect of salbutamol on pulmonary responsiveness in chronic pulmonary allergic inflammation in guinea pigs.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2005, Volume: 38, Issue:5

    Topics: Adrenergic beta-Agonists; Albuterol; Animals; Asthma; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Guinea Pigs; Male; Methacholine Chloride; Ovalbumin; Time Factors

2005
Effects of corticosteroid on the expression of thymus and activation-regulated chemokine in a murine model of allergic asthma.
    International archives of allergy and immunology, 2005, Volume: 137 Suppl 1

    Topics: Adrenal Cortex Hormones; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Count; Chemokine CCL17; Chemokines, CC; Dexamethasone; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Receptors, CCR4; Receptors, Chemokine; Receptors, CXCR3; Reverse Transcriptase Polymerase Chain Reaction; RNA

2005
Interleukin-13-dependent bronchial hyper-responsiveness following isolated upper-airway allergen challenge in a murine model of allergic rhinitis and asthma.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2005, Volume: 35, Issue:8

    Topics: Administration, Intranasal; Allergens; Animals; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Granulocytes; Humans; Immunoglobulin E; Immunoglobulin G; Interleukin-13; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Hypersensitivity

2005
TNF-alpha induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A(2) activation.
    The Journal of allergy and clinical immunology, 2005, Volume: 116, Issue:3

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytosol; Disease Models, Animal; Enzyme Activation; Histamine; Inflammation; Leukotriene B4; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Phospholipases A; Platelet Activating Factor; Pulmonary Eosinophilia; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha

2005
Exaggerated airway narrowing in mice treated with intratracheal cationic protein.
    Journal of applied physiology (Bethesda, Md. : 1985), 2006, Volume: 100, Issue:2

    Topics: Administration, Inhalation; Animals; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Cations; Disease Models, Animal; Dose-Response Relationship, Drug; Intubation, Intratracheal; Methacholine Chloride; Mice; Mice, Inbred BALB C; Muscle, Smooth; Polylysine; Proteins; Respiratory Mucosa; Respiratory System; Time Factors

2006
The PPARgamma ligand, rosiglitazone, reduces airways hyperresponsiveness in a murine model of allergen-induced inflammation.
    Pulmonary pharmacology & therapeutics, 2006, Volume: 19, Issue:1

    Topics: Allergens; Animals; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Goblet Cells; Guinea Pigs; Hyperplasia; In Vitro Techniques; Injections, Intraperitoneal; Ligands; Matrix Metalloproteinase 2; Methacholine Chloride; Mice; Mice, Inbred C57BL; Muscle Contraction; Ovalbumin; Pneumonia; PPAR gamma; Respiratory Hypersensitivity; Rosiglitazone; Thiazolidinediones; Time Factors; Trachea; Vasodilator Agents

2006
Effect of adenosine A2A receptor activation in murine models of respiratory disorders.
    American journal of physiology. Lung cellular and molecular physiology, 2006, Volume: 290, Issue:5

    Topics: Aerosols; Allergens; Animals; Bronchoconstriction; Disease Models, Animal; Female; Leukocyte Count; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pulmonary Disease, Chronic Obstructive; Receptor, Adenosine A2A; Respiratory Function Tests

2006
Intestinal ischemia/reperfusion induces bronchial hyperreactivity and increases serum TNF-alpha in rats.
    Clinics (Sao Paulo, Brazil), 2006, Volume: 61, Issue:1

    Topics: Animals; Bronchial Hyperreactivity; Disease Models, Animal; Intestines; Liver; Male; Methacholine Chloride; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar; Reperfusion Injury; Tumor Necrosis Factor-alpha

2006
Oxidant stress modulates murine allergic airway responses.
    Free radical biology & medicine, 2006, Apr-01, Volume: 40, Issue:7

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; F2-Isoprostanes; Female; Lipid Peroxidation; Lung; Macrophages, Alveolar; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Ovalbumin; Oxidative Stress; Specific Pathogen-Free Organisms; Spectrometry, Mass, Electrospray Ionization; Vitamin E; Vitamin E Deficiency

2006
Respiratory syncytial virus infection in a murine model of cystic fibrosis.
    Journal of medical virology, 2006, Volume: 78, Issue:5

    Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Inflammation; Lung; Lymphocytes; Methacholine Chloride; Mice; Mice, Inbred CFTR; Neutrophils; Nitrates; Nitric Oxide; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses

2006
Antigen sensitization modulates alveolar macrophage functions in an asthma model.
    American journal of physiology. Lung cellular and molecular physiology, 2006, Volume: 290, Issue:5

    Topics: Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Clodronic Acid; Disease Models, Animal; Lung; Macrophages, Alveolar; Male; Methacholine Chloride; Ovalbumin; Rats; Rats, Inbred BN; Tumor Necrosis Factor-alpha

2006
Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma.
    International immunopharmacology, 2006, Volume: 6, Issue:6

    Topics: Acetates; Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cyclopropanes; Disease Models, Animal; Female; Glucosides; Immunoglobulin E; Interleukin-13; Interleukin-4; Iridoid Glucosides; Iridoids; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Molecular Structure; Mucus; Ovalbumin; Plant Extracts; Pneumonia; Pulmonary Eosinophilia; Quinolines; Sulfides; Veronica

2006
Histamine type 1 receptor deficiency reduces airway inflammation in a murine asthma model.
    International archives of allergy and immunology, 2006, Volume: 140, Issue:3

    Topics: Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Histocytochemistry; Hypersensitivity; Immunoglobulin E; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovalbumin; Receptors, Histamine H1; Specific Pathogen-Free Organisms

2006
Mast cells can promote the development of multiple features of chronic asthma in mice.
    The Journal of clinical investigation, 2006, Volume: 116, Issue:6

    Topics: Animals; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Chronic Disease; Disease Models, Animal; Female; Humans; Hyperplasia; Mast Cells; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovalbumin; Proto-Oncogene Proteins c-kit; Receptors, IgG; Respiratory Mucosa

2006
Effects of cryptoporus polysaccharide on rat allergic rhinitis associated with inhibiting eotaxin mRNA expression.
    Journal of ethnopharmacology, 2006, Oct-11, Volume: 107, Issue:3

    Topics: Airway Resistance; Animals; Anti-Allergic Agents; Bronchial Hyperreactivity; Bronchial Provocation Tests; Chemokine CCL11; Chemokines, CC; Chemotaxis, Leukocyte; Disease Models, Animal; Eosinophils; Fruiting Bodies, Fungal; Gene Expression Regulation; Lung; Lung Compliance; Methacholine Chloride; Nasal Mucosa; Ovalbumin; Polyporaceae; Polysaccharides; Rats; Rats, Sprague-Dawley; Rhinitis, Allergic, Seasonal; RNA, Messenger

2006
Smooth muscle myosin isoform expression and LC20 phosphorylation in innate rat airway hyperresponsiveness.
    American journal of physiology. Lung cellular and molecular physiology, 2006, Volume: 291, Issue:5

    Topics: Actins; Animals; Blotting, Western; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Calmodulin-Binding Proteins; Disease Models, Animal; Isomerism; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Myosin Heavy Chains; Myosin Light Chains; Phosphorylation; Rats; Rats, Inbred F344; Rats, Inbred Lew; Reverse Transcriptase Polymerase Chain Reaction; Smooth Muscle Myosins

2006
Increased prostanoid dependency of arterial relaxation in Chlamydia pneumoniae-infected mice.
    Journal of medical microbiology, 2006, Volume: 55, Issue:Pt 8

    Topics: Animals; Aorta, Thoracic; Chlamydophila Infections; Chlamydophila pneumoniae; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Enzyme Inhibitors; Female; Methacholine Chloride; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Prostaglandins; Vasoconstrictor Agents; Vasodilation

2006
CD38-deficient mice have reduced airway hyperresponsiveness following IL-13 challenge.
    American journal of physiology. Lung cellular and molecular physiology, 2006, Volume: 291, Issue:6

    Topics: ADP-ribosyl Cyclase 1; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Interleukin-13; Kinetics; Membrane Glycoproteins; Methacholine Chloride; Mice; Mice, Knockout

2006
Inhibition of mucin secretion with MARCKS-related peptide improves airway obstruction in a mouse model of asthma.
    Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 102, Issue:1

    Topics: Airway Obstruction; Animals; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucins; Peptide Fragments

2007
Effects of ciclamilast, a new PDE 4 PDE4 inhibitor, on airway hyperresponsiveness, PDE4D expression and airway inflammation in a murine model of asthma.
    European journal of pharmacology, 2006, Oct-10, Volume: 547, Issue:1-3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Allergens; Animals; Anti-Inflammatory Agents; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchitis; Bronchoalveolar Lavage Fluid; Chemokines; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Eosinophilia; Female; Gene Expression; Isoenzymes; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Phosphodiesterase Inhibitors; Pyridines; RNA, Messenger

2006
Immunological determinants of ventilatory changes induced in mice by dermal sensitization and respiratory challenge with toluene diisocyanate.
    American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 292, Issue:1

    Topics: Airway Resistance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Immunoglobulins; In Vitro Techniques; Lymphocytes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, SCID; Skin; Toluene 2,4-Diisocyanate

2007
Intrinsic and antigen-induced airway hyperresponsiveness are the result of diverse physiological mechanisms.
    Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 102, Issue:1

    Topics: Administration, Inhalation; Animals; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Computer Simulation; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intravenous; Mathematics; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Muscle Contraction; Muscle, Smooth; Phenotype; Respiratory Hypersensitivity

2007
Differential effects of low and high dose folic acid on endothelial dysfunction in a murine model of mild hyperhomocysteinaemia.
    European journal of pharmacology, 2006, Dec-03, Volume: 551, Issue:1-3

    Topics: Animals; Clotrimazole; Cystathionine beta-Synthase; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Folic Acid; Homocysteine; Hyperhomocysteinemia; Mesenteric Arteries; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Transgenic; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Vasodilation; Vasodilator Agents

2006
Mouse genetic model for antigen-induced airway manifestations of asthma.
    Genes and immunity, 2007, Volume: 8, Issue:1

    Topics: Animals; Antigens; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Disease Models, Animal; Immunoglobulin E; Male; Methacholine Chloride; Mice; Mice, Congenic; Mice, Inbred BALB C; Mice, Inbred Strains; Ovalbumin; Respiratory System; Species Specificity

2007
Oral treatment with live Lactobacillus reuteri inhibits the allergic airway response in mice.
    American journal of respiratory and critical care medicine, 2007, Mar-15, Volume: 175, Issue:6

    Topics: Administration, Oral; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; DNA, Bacterial; Eosinophils; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Limosilactobacillus reuteri; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Probiotics; Toll-Like Receptor 9; Tryptophan

2007
Enhanced airway reactivity and inflammation in A2A adenosine receptor-deficient allergic mice.
    American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 292, Issue:6

    Topics: Ambrosia; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cyclic AMP; Disease Models, Animal; I-kappa B Proteins; Leukocytes; Lipid Peroxidation; Male; Methacholine Chloride; Mice; Mice, Inbred Strains; Mice, Knockout; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Phosphorylation; Plethysmography, Whole Body; Pneumonia; Reactive Nitrogen Species; Receptor, Adenosine A2A; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor RelA; Tyrosine

2007
Cessation of dexamethasone exacerbates airway responses to methacholine in asthmatic mice.
    European journal of pharmacology, 2007, Jun-01, Volume: 563, Issue:1-3

    Topics: Administration, Oral; Airway Resistance; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Dexamethasone; Disease Models, Animal; Drug Administration Schedule; Eosinophils; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; Pulmonary Eosinophilia; Recurrence

2007
Methacholine responsiveness in mice from 2 to 8 wk of age.
    Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 103, Issue:2

    Topics: Aging; Animals; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Infusions, Intravenous; Lung; Lung Volume Measurements; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pregnancy; Respiratory Mechanics

2007
Immunomodulatory effects of oak dust exposure in a murine model of allergic asthma.
    Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 99, Issue:1

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Chemokine CCL3; Chemokine CCL4; Chemokines, CC; Disease Models, Animal; Dust; Female; Inhalation Exposure; Interleukin-13; Leukocytes; Lung; Macrophage Inflammatory Proteins; Macrophages; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Ovalbumin; Quercus; RNA, Messenger; Tumor Necrosis Factor-alpha; Wood

2007
Synergistic effect of formoterol and mometasone in a mouse model of allergic lung inflammation.
    British journal of pharmacology, 2007, Volume: 152, Issue:1

    Topics: Administration, Intranasal; Adrenergic beta-Agonists; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Ethanolamines; Female; Formoterol Fumarate; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mometasone Furoate; Ovalbumin; Pregnadienediols; Respiratory Function Tests; Respiratory Hypersensitivity; Time Factors

2007
Vasodilator effects of nebivolol in a rat model of hypertension and a rabbit model of congestive heart failure.
    Journal of cardiovascular pharmacology, 2007, Volume: 50, Issue:1

    Topics: Animals; Aorta, Thoracic; Benzopyrans; Disease Models, Animal; Endothelium, Vascular; Ethanolamines; Heart Failure; Hypertension; Male; Methacholine Chloride; Muscarinic Agonists; Nebivolol; Rabbits; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation; Vasodilator Agents

2007
Suppression of the asthmatic phenotype by ultraviolet B-induced, antigen-specific regulatory cells.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2007, Volume: 37, Issue:9

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Immunity, Cellular; Immunization; Immunoglobulin E; Lymph Nodes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phenotype; Rats; Rats, Sprague-Dawley; Ultraviolet Rays; Ultraviolet Therapy

2007
Effect of TRFK-5 on airway responsiveness in ovalbumin-treated guinea pigs exposed to tobacco smoke.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 2007, Volume: 44, Issue:7

    Topics: Animals; Antibodies, Monoclonal; Bronchial Hyperreactivity; Capsaicin; Cell Movement; Disease Models, Animal; Eosinophils; Guinea Pigs; Histamine; Interleukin-5; Male; Methacholine Chloride; Ovalbumin; Tobacco Smoke Pollution

2007
Methacholine-induced pulmonary gas trapping in a mouse model of allergic asthma: effect of inhaled budesonide and ciglitazone.
    European journal of pharmacology, 2008, Jan-06, Volume: 578, Issue:1

    Topics: Administration, Inhalation; Airway Obstruction; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchodilator Agents; Budesonide; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; PPAR gamma; Thiazolidinediones

2008
Effects of allergen on airway narrowing dynamics as assessed by lung-slice technique.
    The European respiratory journal, 2008, Volume: 31, Issue:3

    Topics: Airway Resistance; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Disease Models, Animal; Image Processing, Computer-Assisted; Methacholine Chloride; Mice; Mice, Inbred BALB C; Microscopy, Video; Muscle, Smooth; Ovalbumin

2008
Impact of lung remodelling on respiratory mechanics in a model of severe allergic inflammation.
    Respiratory physiology & neurobiology, 2008, Feb-29, Volume: 160, Issue:3

    Topics: Animals; Asthma; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperplasia; Hypertrophy; Methacholine Chloride; Mice; Mice, Inbred BALB C; Microscopy, Electron; Muscarinic Agonists; Muscle, Smooth; Ovalbumin; Pulmonary Alveoli; Pulmonary Eosinophilia; Respiratory Hypersensitivity; Respiratory Mechanics

2008
Estrogen determines sex differences in airway responsiveness after allergen exposure.
    American journal of respiratory cell and molecular biology, 2008, Volume: 38, Issue:5

    Topics: Allergens; Animals; Bronchial Hyperreactivity; Disease Models, Animal; Estradiol; Estrogen Receptor Modulators; Estrogens; Female; Fulvestrant; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neurokinin A; Neurokinin-1 Receptor Antagonists; Ovalbumin; Sex Characteristics

2008
Pharmacological analysis of the interaction of antimuscarinic drugs at M(2) and M(3) muscarinic receptors in vivo using the pithed rat assay.
    Naunyn-Schmiedeberg's archives of pharmacology, 2008, Volume: 376, Issue:5

    Topics: Animals; Blood Pressure; Bradycardia; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Infusions, Intravenous; Methacholine Chloride; Muscarinic Antagonists; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3

2008
Ovalbumin-sensitized mice are good models for airway hyperresponsiveness but not acute physiological responses to allergen inhalation.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2008, Volume: 38, Issue:5

    Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Female; Humans; Immunoglobulin E; Immunoglobulin G; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Time Factors

2008
Shortening of the induction period of allergic asthma in cynomolgus monkeys by Ascaris suum and house dust mite.
    Journal of pharmacological sciences, 2008, Volume: 106, Issue:1

    Topics: Administration, Inhalation; Administration, Oral; Airway Resistance; Allergens; Androstadienes; Animals; Anti-Asthmatic Agents; Antigens, Dermatophagoides; Ascaris suum; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cells, Cultured; Disease Models, Animal; Fluticasone; Helminth Proteins; Immunoglobulin E; Injections, Intramuscular; Injections, Intraperitoneal; Interleukin-4; Interleukin-5; Intradermal Tests; Leukocytes, Mononuclear; Macaca fascicularis; Male; Methacholine Chloride; Prednisolone; Receptors, CCR4; T-Lymphocytes, Helper-Inducer; Time Factors

2008
Ym1 and Ym2 expression in a mouse model exposed to diesel exhaust particles.
    Environmental toxicology, 2008, Volume: 23, Issue:1

    Topics: Air Pollutants; Animals; Asthma; beta-N-Acetylhexosaminidases; Bronchoalveolar Lavage Fluid; Chitinases; Disease Models, Animal; Environmental Monitoring; Female; Gasoline; Gene Expression; Inhalation Exposure; Interleukin-4; Lectins; Methacholine Chloride; Mice; Mice, Inbred BALB C; Particle Size; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Specific Pathogen-Free Organisms; Vehicle Emissions

2008
Acute salivary gland hypofunction in the duct ligation model in the absence of inflammation.
    Oral diseases, 2008, Volume: 14, Issue:6

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Dexamethasone; Disease Models, Animal; Glucocorticoids; Ligation; Macrophages; Methacholine Chloride; Neutrophils; Parasympathomimetics; Peroxidase; Potentiometry; Rats; Rats, Wistar; Saliva; Salivary Ducts; Salivary Proteins and Peptides; Secretory Rate; Sialadenitis; Submandibular Gland; Submandibular Gland Diseases; Time Factors; Xerostomia

2008
Cholinergic nitric oxide release from the urinary bladder mucosa in cyclophosphamide-induced cystitis of the anaesthetized rat.
    British journal of pharmacology, 2008, Volume: 153, Issue:7

    Topics: Animals; Cyclophosphamide; Cystitis; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Methacholine Chloride; Mucous Membrane; Muscarinic Agonists; Muscarinic Antagonists; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M3; Receptor, Muscarinic M5; Urinary Bladder; Urothelium

2008
Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation.
    Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 104, Issue:6

    Topics: Airway Resistance; Animals; Body Weight; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Inflammation Mediators; Injections, Intravenous; Lung Compliance; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Obesity; Ozone; Phenotype; Pneumonia; Pulmonary Edema; Respiratory Mechanics

2008
Establishing the phenotype in novel acute and chronic murine models of allergic asthma.
    International immunopharmacology, 2008, Volume: 8, Issue:5

    Topics: Acute Disease; Administration, Inhalation; Allergens; Animals; Antibodies; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cell Count; Chronic Disease; Disease Models, Animal; Hypersensitivity; Immunoglobulin E; Immunoglobulin G; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phenotype; Plethysmography, Whole Body; Pneumonia; Respiratory Function Tests

2008
Computational assessment of airway wall stiffness in vivo in allergically inflamed mouse models of asthma.
    Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 104, Issue:6

    Topics: Airway Resistance; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Computer Simulation; Disease Models, Animal; Elasticity; Female; Inflammation; Injections, Intravenous; Methacholine Chloride; Mice; Mice, Inbred BALB C; Models, Biological; Ovalbumin; Time Factors

2008
Animal models of airway sensitization.
    Current protocols in immunology, 2007, Volume: Chapter 15

    Topics: Airway Resistance; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cell Count; Cell Proliferation; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunity, Cellular; Immunization; Lung Compliance; Methacholine Chloride; Mice; Ovalbumin; Plethysmography, Whole Body

2007
Mepacrine alleviates airway hyperresponsiveness and airway inflammation in a mouse model of asthma.
    International immunopharmacology, 2008, Volume: 8, Issue:6

    Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cysteine; Cytokines; Disease Models, Animal; Eosinophils; Immunoglobulin E; Inflammation; Leukotrienes; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phospholipases A2, Secretory; Quinacrine

2008
Attenuated methacholine airway response following repeat testing in a murine model of allergic airways disease.
    Experimental lung research, 2008, Volume: 34, Issue:5

    Topics: Animals; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Female; Inflammation; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin

2008
Basenji-greyhound dog model of asthma: pulmonary responses after beta-adrenergic blockade.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1981, Volume: 51, Issue:6

    Topics: Adrenergic beta-Antagonists; Aerosols; Airway Resistance; Animals; Asthma; Citrates; Citric Acid; Disease Models, Animal; Dogs; Heart Rate; Lung Compliance; Methacholine Chloride; Methacholine Compounds; Respiration

1981
[The abnormal ECG and the appearance of methacholine-induced arrhythmias in SART mice and effects of beta-blockers, oxprenolol, propranolol, and carteolol].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1984, Volume: 83, Issue:5

    Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System Diseases; Carteolol; Disease Models, Animal; Electrocardiography; Male; Methacholine Chloride; Methacholine Compounds; Mice; Oxprenolol; Propanolamines; Propranolol

1984
Parainfluenza virus type-3 infection attenuates the respiratory effects of antigen challenge in sensitized guinea pigs.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995, Volume: 44, Issue:3

    Topics: Aerosols; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Dyspnea; Eosinophils; Guinea Pigs; Histamine Release; In Vitro Techniques; Male; Methacholine Chloride; Ovalbumin; Parainfluenza Virus 3, Human; Paramyxoviridae Infections

1995
Involvement of thromboxane A2 in propranolol-induced bronchoconstriction after allergic bronchoconstriction in guinea pigs.
    American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:6

    Topics: Administration, Inhalation; Analysis of Variance; Animals; Asthma; Bridged Bicyclo Compounds; Bronchial Provocation Tests; Constriction, Pathologic; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Guinea Pigs; Hypersensitivity; Inflammation; Injections, Intravenous; Male; Methacholine Chloride; Premedication; Propranolol; Receptors, Prostaglandin; Thromboxane A2; Time Factors

1994
[Nonspecific inhalative provocation in the sheep as an asthma model--correlation of respiratory and cardiovascular effects].
    Pneumologie (Stuttgart, Germany), 1994, Volume: 48, Issue:6

    Topics: Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Carbon Dioxide; Disease Models, Animal; Dose-Response Relationship, Drug; Lung Volume Measurements; Methacholine Chloride; Oxygen; Pulmonary Wedge Pressure; Sheep; Ventilation-Perfusion Ratio

1994
Virus-induced airway inflammation and hyperresponsiveness in the guinea-pig is inhibited by levodropropizine.
    Naunyn-Schmiedeberg's archives of pharmacology, 1993, Volume: 348, Issue:2

    Topics: Animals; Antitussive Agents; Bronchial Hyperreactivity; Bronchitis; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Guinea Pigs; Histamine; Leukocytes; Male; Methacholine Chloride; Parainfluenza Virus 3, Human; Paramyxoviridae Infections; Premedication; Propylene Glycols; Specific Pathogen-Free Organisms

1993
Effect of KRN2391, a novel vasodilator, on various experimental anginal models in rats.
    Japanese journal of pharmacology, 1993, Volume: 63, Issue:1

    Topics: Angina Pectoris; Animals; Disease Models, Animal; Electrocardiography; Injections, Intravenous; Isoproterenol; Male; Methacholine Chloride; Niacinamide; Nicorandil; Nifedipine; Pyridines; Rats; Rats, Wistar; Vasodilator Agents

1993
Endothelium dependent relaxation in two different models of chronic heart failure and the effect of ibopamine.
    Cardiovascular research, 1993, Volume: 27, Issue:12

    Topics: Animals; Aortic Valve Stenosis; Culture Techniques; Deoxyepinephrine; Disease Models, Animal; Endothelium, Vascular; Epinephrine; Heart Failure; Male; Methacholine Chloride; Myocardial Infarction; Norepinephrine; Phenylephrine; Rats; Rats, Wistar; Vasodilator Agents

1993
Impaired beta-adrenergic receptor activation of adenylyl cyclase in airway smooth muscle in the basenji-greyhound dog model of airway hyperresponsiveness.
    American journal of respiratory cell and molecular biology, 1993, Volume: 8, Issue:6

    Topics: Adenylyl Cyclases; Analysis of Variance; Animals; Bronchial Hyperreactivity; Bucladesine; Cholera Toxin; Colforsin; Dinoprostone; Disease Models, Animal; Dogs; Enzyme Activation; Immunoblotting; Isoproterenol; Lung; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Radioimmunoassay; Receptors, Adrenergic, beta; Trachea

1993
Effect of FK409, a novel nitric oxide donor, on acute experimental myocardial ischemia.
    Japanese journal of pharmacology, 1993, Volume: 62, Issue:3

    Topics: Animals; Coronary Circulation; Coronary Vessels; Dipyridamole; Disease Models, Animal; Dogs; Electric Stimulation; Electrocardiography; Female; In Vitro Techniques; Male; Methacholine Chloride; Myocardial Ischemia; Nitric Oxide; Nitro Compounds; Nitroglycerin; Rats; Vasodilation; Vasodilator Agents

1993
Effects of a thromboxane synthase inhibitor (CS-518) on the eosinophil-dependent late asthmatic response and airway hyperresponsiveness in guinea pigs.
    International archives of allergy and immunology, 1996, Volume: 109, Issue:1

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Chemotaxis, Leukocyte; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eosinophils; Guinea Pigs; Male; Methacholine Chloride; Ovalbumin; Pulmonary Eosinophilia; Thiophenes; Thromboxane-A Synthase

1996
Relationship between airway eosinophilia and airway hyperresponsiveness in a late asthmatic model of guinea pigs.
    International archives of allergy and immunology, 1996, Volume: 109, Issue:1

    Topics: Animals; Antibodies; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Eosinophils; Guinea Pigs; Histamine; Interleukin-5; Leukocyte Count; Leukotriene C4; Male; Methacholine Chloride; Ovalbumin; Passive Cutaneous Anaphylaxis; Pulmonary Eosinophilia; Thromboxane B2; Time Factors

1996
Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.
    The Journal of experimental medicine, 1996, Jan-01, Volume: 183, Issue:1

    Topics: Aerosols; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophilia; Interleukin-5; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Ovalbumin; Respiratory System

1996
Methacholine-induced histamine liberation during airway challenge tests in Ascaris skin-sensitive sheep.
    Respiration; international review of thoracic diseases, 1995, Volume: 62, Issue:6

    Topics: Aerosols; Airway Obstruction; Airway Resistance; Allergens; Animals; Ascaris; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Dermatitis, Allergic Contact; Disease Models, Animal; Elasticity; Electric Stimulation; Histamine; Histamine Release; Inhalation; Intubation, Intratracheal; Methacholine Chloride; Pressure; Reproducibility of Results; Respiratory Mechanics; Respiratory Muscles; Sheep; Vagotomy; Vagus Nerve

1995
The effects of three models of airway disease on tidal breathing flow-volume loops of thoroughbred horses.
    Veterinary research communications, 1995, Volume: 19, Issue:6

    Topics: Administration, Inhalation; Aerosols; Airway Resistance; Animals; Bronchoconstrictor Agents; Disease Models, Animal; Expiratory Reserve Volume; Female; Histamine; Horse Diseases; Horses; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Random Allocation; Respiratory System; Respiratory Tract Diseases; Tidal Volume

1995
Characterization of a primate model of asthma using anti-allergy/anti-asthma agents.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45, Issue:5

    Topics: Albuterol; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Antigens; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Cetirizine; Dexamethasone; Disease Models, Animal; Leukocytes; Macaca fascicularis; Male; Methacholine Chloride; Pyrilamine; Salmeterol Xinafoate

1996
The importance of leukotrienes in airway inflammation in a mouse model of asthma.
    The Journal of experimental medicine, 1996, Oct-01, Volume: 184, Issue:4

    Topics: 5-Lipoxygenase-Activating Proteins; Allergens; Animals; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Carrier Proteins; Disease Models, Animal; Female; Immunoglobulin E; Inflammation; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Membrane Proteins; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucus; Ovalbumin; Pulmonary Eosinophilia; Respiratory Function Tests; Respiratory System

1996
Inhibition of T cell costimulation abrogates airway hyperresponsiveness in a murine model.
    The Journal of clinical investigation, 1996, Dec-15, Volume: 98, Issue:12

    Topics: Airway Resistance; Animals; Bronchoalveolar Lavage; Bronchoconstrictor Agents; CD28 Antigens; Cell Division; Disease Models, Animal; Flow Cytometry; Histocytochemistry; Hypersensitivity; Immunoglobulin E; Immunoglobulin G; Immunohistochemistry; Inflammation; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; T-Lymphocytes

1996
Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction.
    The Journal of clinical investigation, 1996, Dec-15, Volume: 98, Issue:12

    Topics: Airway Obstruction; Airway Resistance; Animals; Blotting, Northern; Blotting, Southern; Cloning, Molecular; Disease Models, Animal; Gene Expression Regulation; Histocytochemistry; Immunohistochemistry; Interleukin-11; Lung; Methacholine Chloride; Mice; Mice, Transgenic; Microscopy, Electron; Promoter Regions, Genetic; Proteins; Pulmonary Fibrosis; Uteroglobin

1996
Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration.
    American journal of respiratory cell and molecular biology, 1997, Volume: 16, Issue:3

    Topics: Administration, Inhalation; Aerosols; Animals; Antibodies, Monoclonal; Antigens; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophil Peroxidase; Eosinophils; Interferon-gamma; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Peroxidases

1997
Tracheal gas insufflation improves ventilatory efficiency during metacholine-induced bronchospasm.
    Journal of critical care, 1997, Volume: 12, Issue:1

    Topics: Animals; Bronchial Spasm; Bronchoconstrictor Agents; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Hemodynamics; Insufflation; Methacholine Chloride; Oxygen Inhalation Therapy; Pulmonary Gas Exchange; Respiration, Artificial; Trachea

1997
Airway hyperresponsiveness in a rat model of chronic bronchitis: role of C fibers.
    American journal of respiratory and critical care medicine, 1997, Volume: 155, Issue:4

    Topics: Animals; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Bronchoconstrictor Agents; Capsaicin; Disease Models, Animal; Female; Methacholine Chloride; Nerve Fibers; Rats; Rats, Sprague-Dawley; Respiratory Mechanics; Sulfur Dioxide; Trachea

1997
Murine CTLA4-IgG treatment inhibits airway eosinophilia and hyperresponsiveness and attenuates IgE upregulation in a murine model of allergic asthma.
    American journal of respiratory cell and molecular biology, 1997, Volume: 17, Issue:3

    Topics: Abatacept; Administration, Inhalation; Animals; Antigens, CD; Antigens, Differentiation; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoconstrictor Agents; CTLA-4 Antigen; Cytokines; Disease Models, Animal; Eosinophilia; Immunoconjugates; Immunoglobulin E; Immunoglobulin G; Immunosuppressive Agents; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Protein Binding; Pulmonary Alveoli; Specific Pathogen-Free Organisms; Spleen; Up-Regulation

1997
Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography.
    American journal of respiratory and critical care medicine, 1997, Volume: 156, Issue:3 Pt 1

    Topics: Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Disease Models, Animal; Female; Humans; Hypersensitivity; Methacholine Chloride; Mice; Mice, Inbred BALB C; Plethysmography, Whole Body; Reproducibility of Results

1997
Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma.
    The Journal of clinical investigation, 1997, Dec-15, Volume: 100, Issue:12

    Topics: Allergens; Animals; Antibodies, Monoclonal; Antigens, CD; Asthma; Bronchoconstrictor Agents; Cell Movement; Disease Models, Animal; Eosinophils; Female; Humans; Integrin alpha4; Leukocytes; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Hypersensitivity; Th2 Cells

1997
Respiratory syncytial virus affects pulmonary function in BALB/c mice.
    The Journal of infectious diseases, 1998, Volume: 177, Issue:2

    Topics: Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cells, Cultured; Disease Models, Animal; Leukocyte Count; Lymphocyte Count; Lymphocytes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Plethysmography, Whole Body; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Weight Loss

1998
Partitioning of alterations in pulmonary mechanics due to vascular engorgement in piglets.
    Pediatric pulmonology, 1998, Volume: 25, Issue:1

    Topics: Airway Resistance; Analysis of Variance; Animals; Animals, Newborn; Blood Volume; Bronchial Provocation Tests; Catheterization; Disease Models, Animal; Methacholine Chloride; Pulmonary Circulation; Reference Values; Respiratory Mechanics

1998
CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma.
    American journal of respiratory cell and molecular biology, 1998, Volume: 18, Issue:4

    Topics: Abatacept; Airway Resistance; Animals; Antibodies, Helminth; Antigens, CD; Antigens, Differentiation; Antigens, Helminth; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; CTLA-4 Antigen; Culture Media, Conditioned; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophilia; Female; Humans; Immunoconjugates; Immunoglobulin E; Immunosuppressive Agents; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Recombinant Fusion Proteins; Schistosoma mansoni; T-Lymphocytes; Th1 Cells; Th2 Cells

1998
Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice.
    The Journal of clinical investigation, 1998, Apr-15, Volume: 101, Issue:8

    Topics: Administration, Cutaneous; Aerosols; Allergens; Animals; Antibody Specificity; Asthma; Base Sequence; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Dermatitis, Atopic; Disease Models, Animal; DNA Primers; Eosinophilia; Female; Immunization; Immunoglobulin E; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; RNA, Messenger; Skin

1998
Repeated measurements of airway and parenchymal mechanics in rats by using low-frequency oscillations.
    Journal of applied physiology (Bethesda, Md. : 1985), 1998, Volume: 84, Issue:5

    Topics: Aerosols; Airway Resistance; Animals; Disease Models, Animal; Hypersensitivity; Lung; Male; Methacholine Chloride; Rats; Respiratory Mechanics; Thorax

1998
Allergen immunotherapy inhibits airway eosinophilia and hyperresponsiveness associated with decreased IL-4 production by lymphocytes in a murine model of allergic asthma.
    American journal of respiratory cell and molecular biology, 1998, Volume: 19, Issue:4

    Topics: Alveolitis, Extrinsic Allergic; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Desensitization, Immunologic; Disease Models, Animal; Immunoglobulin E; Immunoglobulin G; Interferon-gamma; Interleukin-4; Lymph Nodes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Pulmonary Eosinophilia; Specific Pathogen-Free Organisms; T-Lymphocytes

1998
Inhalation anaesthetics produce asynchronous reversal of ventilation inhomogeneity and increased lung resistance in a canine model of bronchial asthma.
    British journal of anaesthesia, 1998, Volume: 80, Issue:6

    Topics: Airway Resistance; Anesthetics, Inhalation; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Methacholine Chloride; Respiratory Mechanics

1998
Differential effects of endogenous and exogenous interferon-gamma on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma.
    American journal of respiratory cell and molecular biology, 1998, Volume: 19, Issue:5

    Topics: Administration, Inhalation; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II; Hypersensitivity; Immunoglobulin E; Injections, Intraperitoneal; Interferon-gamma; Leukocytes; Lymph Nodes; Macrophages, Alveolar; Methacholine Chloride; Mice; Mice, Knockout; Ovalbumin; Spleen; T-Lymphocytes

1998
Both CD80 and CD86 co-stimulatory molecules regulate allergic pulmonary inflammation.
    International immunology, 1998, Volume: 10, Issue:11

    Topics: Animals; Antigens, CD; Asthma; B7-1 Antigen; B7-2 Antigen; Bronchial Hyperreactivity; Cytokines; Disease Models, Animal; Eosinophilia; Lung; Lymphocyte Activation; Male; Membrane Glycoproteins; Methacholine Chloride; Mice; Mice, Inbred BALB C; Respiratory Hypersensitivity; T-Lymphocytes; Th2 Cells

1998
Effects of endogenous superoxide anion and nitric oxide on cholinergic constriction of normal and hyperreactive guinea pig airways.
    American journal of respiratory and critical care medicine, 1998, Volume: 158, Issue:6

    Topics: Administration, Inhalation; Aerosols; Allergens; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bronchodilator Agents; Cholinergic Fibers; Disease Models, Animal; Enzyme Inhibitors; Free Radical Scavengers; Guinea Pigs; Immunization; Methacholine Chloride; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ovalbumin; Parasympathomimetics; Superoxide Dismutase; Superoxides; Trachea

1998
Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice.
    Journal of immunology (Baltimore, Md. : 1950), 1998, Dec-15, Volume: 161, Issue:12

    Topics: Adjuvants, Immunologic; Administration, Intranasal; Allergens; Animals; Anti-Inflammatory Agents; Bone Marrow; Bronchial Hyperreactivity; Bronchial Provocation Tests; CpG Islands; Desensitization, Immunologic; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Eosinophils; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Hypereosinophilic Syndrome; Interferon-gamma; Interleukin-3; Interleukin-5; Methacholine Chloride; Mice; Mice, Inbred BALB C; Oligodeoxyribonucleotides; Ovalbumin; Plethysmography, Whole Body; Pulmonary Eosinophilia; Th2 Cells; Trachea

1998
Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation.
    The Journal of clinical investigation, 1999, Volume: 103, Issue:2

    Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Cytokines; Disease Models, Animal; Eosinophils; Histocytochemistry; Hypersensitivity; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, SCID; Mice, Transgenic; Ovalbumin; Th1 Cells; Th2 Cells

1999
A murine model of latex allergy-induced airway hyperreactivity.
    Lung, 1999, Volume: 177, Issue:2

    Topics: Airway Resistance; Animals; Antibody Specificity; Bronchial Hyperreactivity; Disease Models, Animal; Eosinophils; Immunoglobulin E; Immunoglobulin G; Injections, Intraperitoneal; Latex; Latex Hypersensitivity; Methacholine Chloride; Mice; Mice, Inbred BALB C; Respiratory Mechanics

1999
An in vivo model of beta-adrenoceptor desensitization.
    Journal of pharmacological and toxicological methods, 1998, Volume: 40, Issue:2

    Topics: Administration, Inhalation; Adrenergic beta-Agonists; Albuterol; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Guinea Pigs; Interleukin-1; Intubation, Intratracheal; Isoproterenol; Male; Methacholine Chloride; Respiratory Hypersensitivity

1998
An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen.
    Thorax, 1998, Volume: 53, Issue:10

    Topics: Aerosols; Allergens; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Eosinophils; Epithelium; Female; Immunoglobulin E; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Specific Pathogen-Free Organisms; Trachea

1998
Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma.
    The Journal of experimental medicine, 1999, May-17, Volume: 189, Issue:10

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Calcium; Disease Models, Animal; Gene Targeting; Histocytochemistry; Humans; Isoenzymes; Lung; Methacholine Chloride; Mice; Mice, Knockout; Nitric Oxide Synthase; Ovalbumin; Plethysmography; Pneumonia

1999
Dissociation of airway hyperresponsiveness from immunoglobulin E and airway eosinophilia in a murine model of allergic asthma.
    American journal of respiratory cell and molecular biology, 1999, Volume: 20, Issue:6

    Topics: Animals; Asthma; Bronchoconstrictor Agents; Cell Movement; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophilia; Humans; Immunoglobulin E; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ovalbumin; Respiratory Hypersensitivity

1999
Shifts in lung lymphocyte profiles correlate with the sequential development of acute allergic and chronic tolerant stages in a murine asthma model.
    The American journal of pathology, 1999, Volume: 154, Issue:6

    Topics: Airway Resistance; Animals; Asthma; B-Lymphocytes; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fluorescent Antibody Technique; Hypersensitivity; Immunoglobulin E; Lymphocytes; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Ovalbumin; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes; Time Factors

1999
Can early timed internal atrial defibrillation shocks reduce the atrial defibrillation threshold?
    Pacing and clinical electrophysiology : PACE, 1999, Volume: 22, Issue:8

    Topics: Animals; Atrial Fibrillation; Defibrillators, Implantable; Disease Models, Animal; Electric Countershock; Electrocardiography; Female; Heart Atria; Heart Rate; Infusions, Intravenous; Male; Maximum Allowable Concentration; Methacholine Chloride; Parasympathomimetics; Reproducibility of Results; Sheep; Time Factors

1999
Allergen-induced increase in airway responsiveness, airway eosinophilia, and bone-marrow eosinophil progenitors in mice.
    American journal of respiratory cell and molecular biology, 1999, Volume: 21, Issue:4

    Topics: Allergens; Animals; Asthma; Bone Marrow; Bronchial Hyperreactivity; Colony-Forming Units Assay; Disease Models, Animal; Dogs; Eosinophilia; Eosinophils; Hematopoiesis; Hematopoietic Stem Cells; Humans; Interleukin-5; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin

1999
Critical role of CD23 in allergen-induced bronchoconstriction in a murine model of allergic asthma.
    European journal of immunology, 1999, Volume: 29, Issue:9

    Topics: Allergens; Animals; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Eosinophils; Female; Immunoglobulin E; Macrophages, Alveolar; Methacholine Chloride; Mice; Mice, Congenic; Mice, Inbred BALB C; Mice, Inbred C57BL; Ovalbumin; Receptors, Fc; Receptors, IgE; Time Factors

1999
Induction of atrial fibrillation and flutter in dogs using methacholine.
    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 1999, Volume: 3, Issue:4

    Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Atrial Fibrillation; Atrial Flutter; Cardiac Pacing, Artificial; Disease Models, Animal; Dogs; Forecasting; Halothane; Methacholine Chloride; Propofol; Refractory Period, Electrophysiological

1999
In vivo airway eosinophil accumulation does not enhance antigen- or propranolol-induced bronchoconstriction in guinea pigs.
    Prostaglandins & other lipid mediators, 1999, Volume: 58, Issue:5-6

    Topics: Administration, Inhalation; Administration, Intranasal; Animals; Antigens; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Eosinophils; Guinea Pigs; Lipids; Male; Methacholine Chloride; Mice; Polymyxin B; Propranolol; Respiratory System

1999
Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthma.
    Journal of immunology (Baltimore, Md. : 1950), 2000, Jan-15, Volume: 164, Issue:2

    Topics: Administration, Intranasal; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Movement; Disease Models, Animal; Eosinophils; Female; Humans; Immunoglobulin E; Injections, Intraperitoneal; Leukocytes, Mononuclear; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucus; Ovalbumin; Receptors, Interleukin-4; Solubility

2000
Nasal hyperresponsiveness to histamine induced by repetitive exposure to cedar pollen in guinea-pigs.
    The European respiratory journal, 1999, Volume: 14, Issue:6

    Topics: Administration, Inhalation; Airway Resistance; Allergens; Animals; Atropine; Disease Models, Animal; Guinea Pigs; Histamine; Immunization; Male; Methacholine Chloride; Naphazoline; Nasal Cavity; Pollen; Pyrilamine; Reference Values; Respiratory Hypersensitivity; Rhinitis, Allergic, Perennial; Sensitivity and Specificity; Trees

1999
Sequential development of airway hyperresponsiveness and acute airway obstruction in a mouse model of allergic inflammation.
    International archives of allergy and immunology, 2000, Volume: 121, Issue:1

    Topics: Airway Obstruction; Airway Resistance; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Immunoglobulin E; Immunoglobulin G; Maximal Expiratory Flow Rate; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Plethysmography, Whole Body; Tidal Volume

2000
Effect of suplatast tosilate (IPD-1151T) on a mouse model of asthma: inhibition of eosinophilic inflammation and bronchial hyperresponsiveness.
    International archives of allergy and immunology, 2000, Volume: 121, Issue:2

    Topics: Animals; Anti-Allergic Agents; Arylsulfonates; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Eosinophilia; Female; Immunoglobulin E; Immunoglobulin G; Lung; Methacholine Chloride; Mice; Ovalbumin; Sulfonium Compounds

2000
Recombinant human platelet-activating factor-acetylhydrolase inhibits airway inflammation and hyperreactivity in mouse asthma model.
    Journal of immunology (Baltimore, Md. : 1950), 2000, Mar-15, Volume: 164, Issue:6

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Movement; Disease Models, Animal; Eosinophils; Female; Humans; Interleukin-5; Lung; Macrophages; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucus; Phospholipases A; Platelet Activating Factor; Recombinant Proteins

2000
Differential effects of nitric oxide synthase inhibitors in an in vivo allergic rat model.
    The European respiratory journal, 2000, Volume: 15, Issue:5

    Topics: Animals; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Citrulline; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Hypersensitivity; Male; Methacholine Chloride; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Thiourea

2000
Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice.
    The Journal of experimental medicine, 2000, Aug-07, Volume: 192, Issue:3

    Topics: Allergens; Animals; Asthma; Disease Models, Animal; Mast Cells; Methacholine Chloride; Mice; Ovalbumin; Respiratory Hypersensitivity; Sodium Chloride

2000
Differences in time-related cardiopulmonary responses to hypoxia in three rat strains.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2000, Volume: 22, Issue:5

    Topics: Altitude; Animals; Carbachol; Disease Models, Animal; Endothelin-1; Endothelins; Hypertension, Pulmonary; Hypertrophy; Hypertrophy, Right Ventricular; Hypoxia; In Vitro Techniques; Male; Methacholine Chloride; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Rats, Wistar; Species Specificity; Trachea; Vasoconstriction; Vasodilation

2000
Respiratory syncytial virus (RSV)-induced airway hyperresponsiveness in allergically sensitized mice is inhibited by live RSV and exacerbated by formalin-inactivated RSV.
    The Journal of infectious diseases, 2000, Volume: 182, Issue:3

    Topics: Administration, Intranasal; Animals; Disease Models, Animal; Female; Formaldehyde; Methacholine Chloride; Mice; Mice, Inbred BALB C; Respiratory Hypersensitivity; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Vaccines, Inactivated; Viral Vaccines

2000
Mucosal IL-12 inhibits airway reactivity to methacholine and respiratory failure in murine asthma.
    Experimental lung research, 2000, Volume: 26, Issue:6

    Topics: Adjuvants, Immunologic; Allergens; Asthma; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Interleukin-12; Intubation, Intratracheal; Methacholine Chloride; Pollen; Respiratory Insufficiency; Respiratory Mucosa

2000
Time course of inflammatory and remodeling events in a murine model of asthma: effect of steroid treatment.
    American journal of physiology. Lung cellular and molecular physiology, 2000, Volume: 279, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cell Division; Dexamethasone; Disease Models, Animal; Eosinophils; Epithelial Cells; Fibronectins; Immunoglobulin E; Interleukin-4; Interleukin-5; Leukocyte Count; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mucus; Ovalbumin; Plasma; Pulmonary Alveoli; Respiratory Mucosa; Species Specificity; Time Factors

2000
Endotoxin responsiveness and subchronic grain dust-induced airway disease.
    American journal of physiology. Lung cellular and molecular physiology, 2001, Volume: 280, Issue:2

    Topics: Actins; Acute Disease; Administration, Inhalation; Aerosols; Airway Resistance; Animals; Bronchoalveolar Lavage Fluid; Collagen; Crosses, Genetic; Disease Models, Animal; Dust; Endotoxins; Genetic Predisposition to Disease; Immunohistochemistry; Lung Diseases, Obstructive; Methacholine Chloride; Mice; Mice, Inbred C3H; Neutrophils; Pneumonia; Species Specificity; Zea mays

2001
Inhibition of eosinophilic inflammation in allergen-challenged TNF receptor p55/p75--and TNF receptor p55-deficient mice.
    American journal of respiratory cell and molecular biology, 2001, Volume: 24, Issue:3

    Topics: Allergens; Animals; Antigens, CD; Bronchoalveolar Lavage Fluid; Cell Adhesion; Disease Models, Animal; Endothelium, Vascular; Eosinophils; Inflammation; Interleukin-5; Lung; Methacholine Chloride; Mice; Mice, Knockout; Mice, Transgenic; Microcirculation; Ovalbumin; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Splanchnic Circulation; Tumor Necrosis Factor-alpha

2001
Enhanced airway Th2 response after allergen challenge in mice deficient in CC chemokine receptor-2 (CCR2).
    Journal of immunology (Baltimore, Md. : 1950), 2001, Apr-15, Volume: 166, Issue:8

    Topics: Administration, Inhalation; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Chemokine CCL2; Disease Models, Animal; Eosinophilia; Immunoglobulin E; Immunoglobulin G; Injections, Intraperitoneal; Lung; Lymphocyte Activation; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Ovalbumin; Receptors, CCR2; Receptors, Chemokine; Th2 Cells

2001
Effects of BCG on ovalbumin-induced bronchial hyperreactivity in a guinea pig asthma model.
    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 2001, Volume: 34, Issue:1

    Topics: Animals; Asthma; BCG Vaccine; Biopsy; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Disease Models, Animal; Flow Cytometry; Guinea Pigs; Immunoglobulin G; Immunohistochemistry; Lung; Lymphocyte Subsets; Male; Methacholine Chloride; Nebulizers and Vaporizers; Ovalbumin; Skin; Time Factors

2001
Airway inflammation and bronchial hyperresponsiveness after Mycoplasma pneumoniae infection in a murine model.
    American journal of respiratory cell and molecular biology, 2001, Volume: 24, Issue:5

    Topics: Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation; Interferon-gamma; Leukocyte Count; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mycoplasma pneumoniae; Pneumonia, Mycoplasma; RNA, Messenger

2001
L-Selectin is required for the development of airway hyperresponsiveness but not airway inflammation in a murine model of asthma.
    The Journal of allergy and clinical immunology, 2001, Volume: 107, Issue:6

    Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Flow Cytometry; Humans; Immunoglobulin E; Inflammation; L-Selectin; Leukocyte Count; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Ovalbumin

2001
Comparison of the anti-bronchoconstrictor activities of inhaled formoterol, its (R,R)- and (S,S)-enantiomers and salmeterol in the rhesus monkey.
    Pulmonary pharmacology & therapeutics, 2001, Volume: 14, Issue:4

    Topics: Administration, Inhalation; Airway Resistance; Albuterol; Animals; Bronchial Spasm; Bronchoconstrictor Agents; Bronchodilator Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanolamines; Formoterol Fumarate; Macaca mulatta; Male; Methacholine Chloride; Salmeterol Xinafoate; Tachycardia

2001
Tumor necrosis factor receptor 2 contributes to ozone-induced airway hyperresponsiveness in mice.
    American journal of respiratory and critical care medicine, 2001, Aug-15, Volume: 164, Issue:4

    Topics: Administration, Inhalation; Animals; Animals, Wild; Antigens, CD; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Environmental Exposure; Leukocyte Count; Methacholine Chloride; Mice; Mice, Knockout; Neutrophils; Oxidants, Photochemical; Ozone; Plethysmography, Whole Body; Pulmonary Ventilation; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Time Factors

2001
CTLA4-IgG reverses asthma manifestations in a mild but not in a more "severe" ongoing murine model.
    American journal of respiratory cell and molecular biology, 2001, Volume: 25, Issue:6

    Topics: Abatacept; Aerosols; Allergens; Aluminum Hydroxide; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Antigens, CD; Antigens, Differentiation; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cells, Cultured; CTLA-4 Antigen; Cytokines; Dexamethasone; Disease Models, Animal; Emulsions; Eosinophils; Immunization; Immunoconjugates; Immunoglobulin E; Immunosuppressive Agents; Interleukin-5; Leukocyte Count; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nasal Provocation Tests; Ovalbumin; Specific Pathogen-Free Organisms; T-Lymphocyte Subsets

2001
Construction of single-chain interleukin-12 DNA plasmid to treat airway hyperresponsiveness in an animal model of asthma.
    Human gene therapy, 2001, Nov-20, Volume: 12, Issue:17

    Topics: Allergens; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; COS Cells; Disease Models, Animal; Female; Genetic Therapy; Immunotherapy; Inflammation; Interleukin-12; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Plasmids; Transfection; Vaccines, DNA

2001
Airway hyperresponsiveness in transgenic mice overexpressing platelet activating factor receptor is mediated by an atropine-sensitive pathway.
    American journal of respiratory and critical care medicine, 2002, Jan-15, Volume: 165, Issue:2

    Topics: Animals; Atropine; Bronchial Diseases; Bronchoconstrictor Agents; Bronchodilator Agents; Disease Models, Animal; Free Radical Scavengers; Methacholine Chloride; Mice; Mice, Transgenic; Muscle, Smooth; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Muscarinic; Respiratory System; Serotonin; Signal Transduction

2002
CXCR2 is necessary for the development and persistence of chronic fungal asthma in mice.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Feb-01, Volume: 168, Issue:3

    Topics: Animals; Aspergillus fumigatus; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Movement; Chemokine CCL11; Chemokine CCL4; Chemokine CCL5; Chemokine CXCL10; Chemokines, CC; Chemokines, CXC; Chronic Disease; Disease Models, Animal; Eosinophils; Female; Immunity, Innate; Immunoglobulin E; Interferon-gamma; Interleukin-12; Interleukin-4; Interleukin-5; Lung; Macrophage Inflammatory Proteins; Methacholine Chloride; Mice; Mice, Knockout; Neutrophils; Peroxidase; Receptors, Interleukin-8B; Spores, Fungal; T-Lymphocytes

2002
CD4(+) T-lymphocytes regulate airway remodeling and hyper-reactivity in a mouse model of chronic asthma.
    Laboratory investigation; a journal of technical methods and pathology, 2002, Volume: 82, Issue:4

    Topics: Allergens; Animals; Antibodies, Monoclonal; Asthma; Bronchi; Bronchial Hyperreactivity; CD4-Positive T-Lymphocytes; Chronic Disease; Disease Models, Animal; Female; Image Processing, Computer-Assisted; Immunization; Immunoglobulin G; Immunohistochemistry; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Specific Pathogen-Free Organisms

2002
Nonlinearity of respiratory mechanics during bronchoconstriction in mice with airway inflammation.
    Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 92, Issue:5

    Topics: Administration, Inhalation; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cell Count; Disease Models, Animal; Female; Lung Volume Measurements; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nonlinear Dynamics; Ovalbumin; Pneumonia; Positive-Pressure Respiration; Respiration, Artificial; Respiratory Mechanics

2002
Relationship between density of muscarinic receptors and nasal hypersecretion in a nasal allergic model.
    Japanese journal of pharmacology, 1992, Volume: 59, Issue:4

    Topics: Animals; Autonomic Nervous System; Disease Models, Animal; Guinea Pigs; Immunoglobulin E; Immunoglobulin G; Male; Methacholine Chloride; Nasal Mucosa; Nasal Provocation Tests; Ovalbumin; Parasympathetic Nervous System; Quinuclidinyl Benzilate; Receptors, Muscarinic; Respiratory Hypersensitivity; Tritium

1992
Hyperoxia-induced airway hyperresponsiveness and remodeling in immature rats.
    The American journal of physiology, 1992, Volume: 262, Issue:3 Pt 1

    Topics: Aerosols; Animals; Bronchi; Bronchial Hyperreactivity; Disease Models, Animal; Epithelium; Methacholine Chloride; Muscle, Smooth; Oxygen; Rats; Rats, Inbred Strains

1992
[The mechanism of airway hyperresponsiveness following immediate bronchial response in ovalbumin (OA)-sensitized guinea pigs].
    Arerugi = [Allergy], 1991, Volume: 40, Issue:2

    Topics: Animals; Asthma; Bronchi; Bronchoconstriction; Disease Models, Animal; Guinea Pigs; Male; Methacholine Chloride; Ovalbumin; Receptors, Adrenergic, beta

1991
Nasal mucosal hypersensitivity in guinea pigs intermittently exposed to cold.
    International archives of allergy and applied immunology, 1991, Volume: 96, Issue:2

    Topics: Animals; Cold Temperature; Disease Models, Animal; Guinea Pigs; Histamine; Immune Sera; Male; Methacholine Chloride; Nasal Mucosa; Nasal Provocation Tests; Ovalbumin; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Histamine H1; Receptors, Muscarinic; Respiratory Hypersensitivity; Stress, Physiological

1991
Viral bronchiolitis during early life induces increased numbers of bronchiolar mast cells and airway hyperresponsiveness.
    The American journal of pathology, 1990, Volume: 137, Issue:4

    Topics: Animals; Bronchiolitis; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Eosinophils; Immunization; Mast Cells; Methacholine Chloride; Microscopy, Electron; Neutrophils; Ovalbumin; Parainfluenza Virus 1, Human; Paramyxoviridae Infections; Rats; Respiratory System; Staining and Labeling

1990
Increased metachromatic cells and lymphocytes in bronchoalveolar lavage fluid of dogs with airway hyperreactivity.
    The American review of respiratory disease, 1986, Volume: 133, Issue:3

    Topics: Animals; Body Fluids; Bronchi; Bronchial Provocation Tests; Bronchial Spasm; Citrates; Citric Acid; Cytoplasmic Granules; Disease Models, Animal; Dog Diseases; Dogs; Histamine; Leukocyte Count; Leukocytes; Mast Cells; Methacholine Chloride; Methacholine Compounds; Pulmonary Alveoli; Staining and Labeling; Therapeutic Irrigation

1986
Comparison of drug responses in vivo and in vitro in airways of dogs with and without airway hyperresponsiveness.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:1

    Topics: Aerosols; Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Disease Models, Animal; Dogs; Histamine; In Vitro Techniques; Isoproterenol; Methacholine Chloride; Methacholine Compounds; Muscle Contraction; Muscle, Smooth

1986
Airway responsiveness to inhaled antigen, histamine, and methacholine in inbred, ragweed-sensitized dogs.
    The American review of respiratory disease, 1985, Volume: 132, Issue:2

    Topics: Animals; Asthma; Bronchial Provocation Tests; Disease Models, Animal; Dogs; Female; Histamine; Immunization; Immunoglobulin E; Male; Methacholine Chloride; Methacholine Compounds; Pollen; Radioallergosorbent Test; Skin Tests

1985