methacholine chloride has been researched along with Asthma, Bronchial in 2375 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 319 (13.43) | 18.7374 |
| 1990's | 817 (34.40) | 18.2507 |
| 2000's | 739 (31.12) | 29.6817 |
| 2010's | 432 (18.19) | 24.3611 |
| 2020's | 68 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, Y; Liang, X; Xie, Y; Xu, H; Zheng, J | 1 |
| Burman, JI; Mäkelä, MJ; Remes, ST | 1 |
| Calco, GN; Fryer, AD; Jacoby, DB; Nie, Z; Proskocil, BJ | 1 |
| Bogs, T; Dreher, C; Ganschow, R; Reinsberg, M; Siebert, S; Yavuz, ST | 1 |
| Cannon, J; Feary, J; Fitzgerald, B; Kabir, T; Schofield, S; Szram, J | 1 |
| Ather, JL; Barup, MLT; Mank, MM; Poynter, ME; Reed, LF; Walton, CJ | 1 |
| Beqiraj-Zeqiraj, Q; Kovač, Z; Raffay, TM; Sahiti, F; Sopi, RB; Thaçi, Q | 1 |
| Henry, PJ; Landwehr, KR; Larcombe, AN; Mann, TS; Noble, PB; Shamsuddin, D; Wang, KCW | 1 |
| Antonelli, A; Brusasco, V; Dellacà, R; Gobbi, A; Gulotta, C; Pellegrino, GM; Pellegrino, R; Torchio, R | 1 |
| Chae, S; Choo, BK; Hwang, YH; Jang, S; Kim, HK; Kim, KM; Kim, SH; Kim, T; Kim, YH; Shim, KS; Song, HK; Yang, WK | 1 |
| Takeda, K | 1 |
| Arnold, LA; Emala, CW; Perez-Zoghbi, JF; Sajorda, DR; Webb, DA; Yocum, GT | 1 |
| Bégin, P; Boucher-Lafleur, AM; Boulet, LP; Laprise, C; Lavoie, ME; Madore, AM; Meloche, J; Morin, C | 1 |
| Enseki, M; Furuya, H; Imamura, T; Mochizuki, H; Murayama, Y | 1 |
| Calco, GN; Fryer, AD; Jacoby, DB; Maung, JN; Nie, Z | 1 |
| Bossé, Y; Boucher, M; Boulay, MÈ; Boulet, LP; Côté, A; Henry, C | 1 |
| Dokuni, R; Fukunaga, A; Kamiryo, H; Katsurada, N; Kiriu, T; Kobayashi, K; Nagano, T; Nishigori, C; Nishimura, Y; Yamamoto, M; Yoshioka, A | 1 |
| Cockcroft, DW; Davis, BE | 9 |
| Coates, AL | 1 |
| Feng, Y; Li, L; Li, Z; Liu, L; Ma, S; Wang, J; Wang, X; Wang, Z; Yang, K; Zhu, Y; Zhu, Z | 1 |
| Clayton, F; Deering-Rice, C; Heller, NM; Huecksteadt, T; Leung, D; Paine, R; Poole, JA; Reilly, C; Sanders, K; Trivedi, S; Venosa, A; Warren, KJ; Wyatt, TA | 1 |
| Finlay, P; Smith, E | 1 |
| Bourke, JE; Diao, J; Gregory, KJ; Lam, M; Leach, K | 1 |
| Mihatov Štefanović, I; Vrsalović, R | 1 |
| Bossé, Y; Boucher, M; Gill, R; Henry, C; Rojas-Ruiz, A | 1 |
| Ahn, S; Hegde, A; Kahsai, AW; Lefkowitz, RJ; Liu, S; Maarsingh, H; Sumajit, HC; Walker, JK | 1 |
| Bhutani, M; Brotto, AR; Fuhr, DP; Moore, LE; Rosychuk, RJ; Stickland, MK; Wong, E | 1 |
| Corrigan, C; Kayode, OS; Knock, GA; Maguire, TJA; Ortiz-Zapater, E; Siew, LQC; Till, S; Woszczek, G; Yung, S | 1 |
| Böll, S; Braunschweig, T; Hempel, P; Klein, V; Martin, C; Michely, A; Rieg, AD; Spillner, J; Tenbrock, K; Verjans, E; von Stillfried, S; Wagner, N | 1 |
| Blais, CM; Cockcroft, DW; Davis, BE; Okonkwo, CS | 1 |
| Einisman, HJ; Gaston, B; Lewis, SJ; Lewis, TH; Raffay, TM; Smith, LA; Wijers, C | 1 |
| Barben, J; de Jong, CCM; Goutaki, M; Kuehni, CE; Mozun, R; Pedersen, ESL; Trachsel, D | 1 |
| Batterman, S; Mentz, G; Naidoo, RN; Robins, TG | 1 |
| Bougard, N; Guissard, F; Henket, M; Louis, R; Paulus, V; Schleich, F | 1 |
| Beaudoin, J; Bossé, Y; Clavel, MA; Clisson, M; Gazzola, M; Khadangi, F | 1 |
| Chen, X; Guan, WJ; Guo, ZJ; Sun, BQ; Xia, S; Zhu, Z | 1 |
| Kaczyńska, K; Russjan, E | 1 |
| Padem, N; Saltoun, C | 1 |
| Dean, J; Disse, B; Endriss, V; Fowler, A; Gupta, A; Iacono, P; Khan, N; Singh, D | 1 |
| Chen, YB; Lin, L; Ouyang, WW; Xu, YJ; Yan, JL; Ye, CY; Ye, JL; Zhou, MJ | 1 |
| Alving, K; Janson, C; Kalm-Stephens, P; Malinovschi, A; Nordvall, L; Venge, P | 1 |
| Dong, L; Liu, SF; Nie, Q; Niu, Y; Song, D; Song, W; Wang, X; Wu, G; Zhang, J | 1 |
| Ahmadi, M; Aslani, MR; Ghobadi, H; Heidarzadeh, M; Khaksar, M; Panahpour, H | 1 |
| Chiba, Y; Fukuda, K; Haraguchi, R; Higashimoto, Y; Iwanaga, T; Nishiyama, O; Sano, A; Sano, H; Tohda, Y | 1 |
| Lee, J; Song, JU | 1 |
| Kotaniemi-Syrjänen, A; Lindahl, H; Lohi, J; Mäkelä, MJ; Malmberg, LP; Malmström, K; Pelkonen, AS; Sarna, S | 1 |
| Arakawa, M; Hasegawa, T; Hayashi, M; Kikuchi, T; Kimura, Y; Koya, T; Saito, A; Takeuchi, H; Tsukioka, K; Ueno, H; Watanabe, S | 1 |
| Kalliola, S; Kotaniemi-Syrjänen, A; Lajunen, KT; Mäkelä, MJ; Malmberg, LP; Pelkonen, AS | 1 |
| Cockcroft, DW; Davis, BE; Tollefson, G; Yurach Pikaluk, M | 1 |
| Boskabady, MH; Hadjzadeh, MA; Mokhtari-Zaer, A; Saadat, S | 1 |
| Abramson, MJ; de Klerk, NH; Del Monaco, A; Dennekamp, M; Dimitriadis, C; Fritschi, L; Gwini, SM; Mohebbi, M; Musk, AWB; Sim, MR | 1 |
| Aaron, SD; Ainslie, M; Alvarez, GG; Boulet, LP; Field, SK; FitzGerald, JM; Gupta, S; Hernandez, P; Lemière, C; Mallick, R; Mayers, I; McIvor, RA; Mulpuru, S; Pakhale, S; Selvanathan, J; Sykes, JR; Vandemheen, KL | 1 |
| Bougard, N; Donneau, AF; Guissard, F; Louis, R; Nekoee, H; Paulus, V; Schleich, F | 1 |
| Bowser, JE; Byars, P; Byrne, R; Hunter, CL; Moore, JW; Swiderski, CE; Wills, RW; Wilson, RM | 1 |
| Backer, V; Hvidtfeldt, M; Porsbjerg, C; Sverrild, A | 1 |
| Contaifer, D; Dileepan, M; Ge, XN; Greenberg, YG; Ha, SG; Rao, SP; Rastle-Simpson, S; Sriramarao, P; Wijesinghe, DS | 1 |
| Cockcroft, DW | 8 |
| Hirai, K; Homma, T; Ida, H; Jinno, M; Kashima, A; Kimura, T; Miyata, Y; Ohta, S; Sagara, H; Sato, H; Suganuma, H; Suzuki, S; Tanaka, A; Uno, T; Watanabe, Y; Yamamoto, M | 1 |
| Basu, S; Carlsten, C; Gauvreau, GM; Halayko, AJ; Jha, A; Kidane, B; Kindrachuk, J; O'Byrne, PM; Pascoe, CD; Ragheb, M; Ravandi, A; Ryu, MH; Srinathan, S; Stelmack, GL; Vaghasiya, J | 1 |
| Fu, Z; Gong, C; Liu, F; Liu, S; Qin, J | 1 |
| Chan, WM; Chen, J; Ko, KM; Leong, PK; Leung, HY; Yan, CTM | 1 |
| Bates, JHT; Bhatawadekar, S; Daphtary, N; Dixon, AE; Hodgdon, K; Kaminsky, DA; MacLean, ES; Peters, U | 1 |
| Jung, JH; Kim, GE; Kim, KW; Kim, MJ; Kim, SY; Kim, YH; Park, MR; Sohn, MH | 1 |
| Cui, J; Dong, J; Dong, M; Qin, J; Tang, W; Teng, F; Wang, S; Wang, W; Wei, Y; Wuniqiemu, T; Zhu, X | 1 |
| Abma, W; Adner, M; Alvarado-Vazquez, PA; Feyerabend, TB; Hallgren, J; Janson, C; Malinovschi, A; Mendez-Enriquez, E; Rodewald, HR; Rodin, S; Simonson, OE | 1 |
| Gao, J; Wu, F; Wu, H | 1 |
| Saad, HB | 1 |
| An, J; Li, J; Wang, H; Xie, Y; Zheng, J; Zhu, Z | 1 |
| Ansarin, K; Nazemiyah, M; Nouri-Vaskeh, M; Sadegi, T; Sharifi, A | 1 |
| Przybyłowski, T; Urbankowski, T | 1 |
| Cohn, J; Onn, A; Ovadya, D; Peled, M; Pullerits, T; Segel, MJ; Seluk, L | 1 |
| Kim, JH; Lim, DH; Samra, MS; Woo, H | 1 |
| Haverkamp, HC; Irvin, CG; Kaminsky, DA; McPherson, SM | 1 |
| Armoni Domany, K; Ater, D; Golan-Lagziel, T; Mandelberg, A; Wolfson, Y | 1 |
| Huprikar, NA; McCann, ET; Morris, MJ; Untisz, JR; Walter, RJ | 1 |
| Carballido Vázquez, AM; Muñiz, C; Pérez de Llano, LA | 1 |
| Coates, AL; Cockcroft, DW; Culver, BH; de Jongh, FHC; Diamant, Z; Gauvreau, G; Hall, GL; Hallstrand, TS; Horvath, I; Joos, G; Kaminsky, DA; Laube, BL; Leuppi, JD; Sterk, PJ; Wanger, J | 1 |
| Abid, A; Heldt, T; Krauss, BS; Mieloszyk, RJ; Verghese, GC | 1 |
| Boyce, JA; Cahill, KN; Castro, M; Chinchilli, VM; Crosby-Thompson, A; Cui, J; DiMango, E; Erzurum, S; Garofalo, D; Israel, E; Jarjour, N; Katz, HR; Kazani, S; Lai, J; Laidlaw, TM; Shenoy, K; Trevor, JL; Wechsler, ME | 1 |
| Capaldi, DPI; Eddy, RL; Guo, F; McCormack, DG; Nair, P; Parraga, G; Sheikh, K; Svenningsen, S | 1 |
| Carpaij, OA; Koppelman, GH; Nieuwenhuis, MAE; Postma, DS; van den Berge, M; Vonk, JM | 1 |
| Broström, EB; Ebersjö, C; Hedlin, G; James, A; Nordlund, B | 1 |
| Gauvreau, GM; Harris, JM; Kotwal, S; MacLean, J; Oliveria, JP; Salter, BM; Scheerens, H; Sehmi, R; Smith, A | 1 |
| Baek, HS; Baek, JH; Choi, SH; Han, MY; Kim, MA; Lee, SJ; Rha, YH; Sheen, YH; Yoon, JW | 1 |
| Davis, JS; Kho, AT; Lu, Q; Moore, KG; Sun, M; Sylvia, JM; Tantisira, KG; Weiss, ST | 1 |
| Blais, CM; Cockcroft, DW; Davis, BE | 3 |
| Bohadana, AB; Izbicki, G; Wild, P | 1 |
| Baudat, A; Bayat, S; Doras, C; Eigenmann, P; Habre, W; Petak, F; Von Garnier, C | 1 |
| Eslami-Behroozi, M; Javan, M; Raoufy, MR | 1 |
| Hong, JY; Kim, HR; Kim, JD; Kim, KW; Kim, MJ; Kim, MN; Kim, SY; Kim, YH; Lee, YJ; Sohn, MH; Sol, IS | 1 |
| Lands, LC; Mazi, A; Zielinski, D | 1 |
| Fu, T; Han, L; Sheng, B; Wang, L; Zeng, Q; Zhang, Y | 1 |
| Arıkoglu, T; Kuyucu, S; Unlu, A; Yıldırım, DD | 1 |
| Ahrens, RC; Singh, S; Wang, K; Zeng, Y | 1 |
| Jang, AS; Kim, BG; Kim, DJ; Lee, J; Lee, PH; Lee, SH; Park, CS; Park, JS; Park, SW; Seo, HJ | 1 |
| Kauppi, P; Mäkelä, MJ; Malmberg, LP | 1 |
| Amirav, I; Ater, D; Attias, M; Mandelberg, A; Nakash, E; Newhouse, MT | 1 |
| Chen, LC; Huang, JL; Huang, SJ; Lin, LL; Ou, LS; Tsao, KC; Yao, TC; Yeh, KW | 1 |
| Amaya, ED; Barranco, P; Coman, I; Domínguez-Ortega, J; Lluncor, M; López-Carrasco, V; Quirce, S | 1 |
| Cavalcante, FSÁ; Gomes, MDM; Leal-Cardoso, JH; Serra, DS | 1 |
| Bengtsson, T; Persson, T; Román, J | 1 |
| Albu, G; Bayat, S; Broche, L; Dégrugilliers, L; Fodor, GH; Habre, W; Peták, F; Porra, L; Sovijärvi, ARA; Strengell, S; Suhonen, H; Suortti, P | 1 |
| Bourque, G; Chiwara, V; de Sanctis, JB; Ho, B; Jeannotte, L; Kanagaratham, C; Moussette, S; Naumova, AK; Radzioch, D; Venuto, D; Youssef, M | 1 |
| Baek, HS; Baek, JH; Choi, SH; Ha, EK; Han, MY; Sheen, YH; Yoon, JW | 1 |
| Brégeon, F; Bues-Charbit, M; Cabon, E; Charpin, D; Del Volgo, MJ; Delliaux, S; Rey, F; Tissier-Ducamp, D | 1 |
| Katial, RK; Kraft, M; Lugogo, NL; Que, LG; Rodman, DM; Shoemaker, SA; Tighe, RM; Troha, JM; Yang, Z | 1 |
| Ilka, F; Javan, M; Raoufy, MR | 1 |
| Altieri, A; Basu, S; Halayko, AJ; Hemshekhar, M; Hiemstra, PS; Mookherjee, N; Piyadasa, H; van der Does, AM | 1 |
| Blais, CM; Cockcroft, DW; Davis, BE; Westbury, GLM | 1 |
| Beydon, N; Chambellan, A; Chenuel, B; Degano, B; Delclaux, C; Dewitte, JD; Dinh-Xuan, AT; Garcia, G; Kauffmann, C; Paris, C; Perez, T; Plantier, L; Poussel, M; Wuyam, B; Zerah-Lancner, F | 1 |
| Boskabady, MH; Eftekhar, N; Kaveh, M; Roshan, NM; Shakeri, F | 1 |
| Antimisiaris, D; Beatty, BL; Cavallazzi, R; Folz, RJ; Gopalraj, R; Jorayeva, A; Myers, J; Polivka, BJ | 1 |
| Taillé, C | 1 |
| Borak, J; Lefkowitz, RY; Linde, B | 1 |
| Aierken, A; Xu, P | 1 |
| Benedetti, A; Ijpma, G; Kachmar, L; Lauzon, AM; Martin, JG; Matusovsky, OS; Panariti, A | 1 |
| Carlsen, KH; Coates, AL; Cockcroft, DW; Culver, BH; de Jongh, FHC; Diamant, Z; Gauvreau, GM; Hall, GL; Hallstrand, TS; Horvath, I; Joos, G; Kaminsky, DA; Laube, BL; Leuppi, JD; Sterk, PJ; Wanger, J | 1 |
| Delecaris, A; Gunst, SJ; Hatch, J; Jalou, H; Krupp, N; Praca, E; Slaven, J; Tepper, RS | 1 |
| Chen, CM; Chiang, BL; Chou, HC; Lin, SC | 1 |
| Hur, J; Kang, JY; Kim, IK; Kim, YK; Lee, J; Lee, JH; Lee, SY; Rhee, CK; Yoon, HJ; Yoon, HK | 1 |
| Gracia-Tabuenca, J; Jauhiainen, M; Kotaniemi-Syrjänen, A; Mäkelä, M; Malmberg, LP; Malmström, K; Pelkonen, A; Seppä, VP; Viik, J | 1 |
| Kalliola, S; Mäkelä, MJ; Malmberg, LP; Malmström, K; Pelkonen, AS | 1 |
| Alipour, MR; Aslani, MR; Boskabady, MH; Ghobadi, H; Keyhanmanesh, R | 1 |
| Cho, HJ; Choi, YJ; Chung, HL; Hong, SJ; Jang, GC; Jung, JA; Jung, S; Kim, HY; Kim, JH; Kim, YH; Kook, MH; Kwon, JW; Lee, SY; Park, JS; Park, KS; Suh, DI; Sun, YH; Woo, HO; Woo, SI; Yang, SI; Yi, HR; Youn, YS | 1 |
| Farah, CS | 1 |
| Gounni, AS; Halayko, AJ; Mohammed, A; Movassagh, H; Ojo, OO; Shan, L | 1 |
| Bonta, PI; Chowdhury, S; Dijkhuis, A; Lutter, R; Ravi, A; Sterk, PJ | 1 |
| Geier, ET; Prisk, GK; Sá, RC; Theilmann, RJ | 1 |
| Wang, F; Yang, X | 1 |
| de Beer, R; de Vos, AF; Morgan, BP; Ramirez Moral, I; Roelofs, JJTH; van 't Veer, C; van der Poll, T; Yang, J | 1 |
| Choi, BS; Jee, HM; Kim, KE; Kim, KW; Lee, HH; Lee, YJ; Sohn, MH | 1 |
| Bacci, E; Bartoli, ML; Cianchetti, S; Costa, F; Dente, FL; Malagrinò, L; Novelli, F; Paggiaro, P; Vagaggini, B | 1 |
| Gauvreau, GM; Grasemann, H; Inman, MD; Khanna, N; North, ML; Scott, JA | 1 |
| Basu, S; Becker, AB; Guan, Q; Halayko, AJ; HayGlass, KT; Ma, AG; Ma, Y; Peng, Z; Warrington, RJ; Weiss, CR | 1 |
| Bernstein, DI; Boulet, LP; Cartier, A; Gautrin, D; Ho, SM; Lummus, ZL; Ouyang, B; Ying, J | 1 |
| Anderson, WJ; Lipworth, BJ; Manoharan, A | 1 |
| Dworski, R; Greenwald, R; Hoskins, A; Johnson, BA | 1 |
| Dinino, EK; Gartman, EJ; Koo, P; McCool, FD; Roberts, MB | 1 |
| Barreno, RX; Blackburn, MR; Cromar, KR; Hallberg, LM; Haque, IU; Hashmi, SS; Hernandez, CB; Johnston, RA; Nadas, AJ; Price, RE; Richards, JB; Schneider, DJ | 1 |
| Antó, J; Burney, P; Cerveri, I; de Marco, R; Heinrich, J; Janson, C; Jarvis, D; Leynaert, B; Marcon, A; Probst-Hensch, N; Svanes, C; Toren, K; Wjst, M | 1 |
| Arcidiacono, G; Caruso, M; Di Maria, GU; Folisi, C; Morjaria, JB; Polosa, R; Prosperini, G; Scuderi, V; Spicuzza, L | 1 |
| Ben-Dov, I; Rabinovich, E; Schwarz, Y; Segel, MJ | 1 |
| Antonelli, A; Brusasco, V; Crimi, C; Dellacà, RL; Dutto, L; Gobbi, A; Gulotta, C; Parola, P; Pellegrino, R; Pompilio, P; Torchio, R | 1 |
| Bikas, C; Dinapogias, E; Ganavias, L; Katsoulis, K; Kontakiotis, T; Kostikas, K; Loukides, S; Michailopoulos, P | 1 |
| Anderson, WJ; Lipworth, BJ; Morrison, AE; Palmer, C; Short, PM; Tavendale, R; Williamson, PA | 1 |
| Cloots, RH; de Theije, CC; Hakvoort, TB; Köhler, SE; Lamers, WH; Poynter, ME; Sankaranarayanan, S; Terwindt, E; van Dijk, P | 1 |
| Dayan, B; Goldberg, S; Joseph, L; Picard, E | 1 |
| Alam, R; Goplen, N; Hanifi, A; Matin, M; Salters, RE | 1 |
| Cheraghvandi, A; Fadaizadeh, L; Masjedi, MR; Taheri, SA | 1 |
| Furuhata, M; Ichijo, H; Mizuguchi, J; Nakae, S; Sudo, K; Takada, E | 1 |
| Hartney, JM; Robichaud, A | 1 |
| Coxson, HO; Kirby, M; McCormack, DG; Parraga, G; Paterson, NA; Starr, D; Svenningsen, S | 1 |
| Bossé, Y; Couture, C; Lee-Gosselin, A; Paré, PD; Pascoe, CD | 1 |
| Aizawa, H; Fukuyama, S; Inoue, H; Komori, M; Koto, H; Matsumoto, K; Takata, S; Yoshida, M | 1 |
| Amakye, DO; Cockcroft, DW; Davis, BE; Martin, AL; Peters, GE | 1 |
| Agus, HM; Berend, N; Brown, NJ; Chapman, DG; Horlyck, KR; Hulme, KM; King, GG; Salome, CM | 1 |
| Camiciottoli, G; Chellini, E; Fontana, GA; Lavorini, F; Magni, C; Pistolesi, M | 1 |
| Baek, JH; Chang, SJ; Choi, SH; Han, MY; Jee, HM; Kim, HY; Shin, YH; Yoon, JW | 1 |
| Backer, V; Garvey, LH; Kyvik, KO; Porsbjerg, C; Sverrild, A; Thomsen, SF; van der Sluis, S | 1 |
| Fei, F; Gong, D; Groffen, J; Heisterkamp, N; Lim, M; Yu, M | 1 |
| Bourdin, A; Chanez, P; Gamez, AS; Kacimi, D; Marin, G; Molinari, N; Paganin, F; Vachier, I | 1 |
| Chen, L; Lai, K; Zhong, N | 1 |
| Brackel, HJ; Hop, WC; Koopman, M; Vaessen-Verberne, AA; van der Ent, CK | 1 |
| Bastien, M; Boulet, LP; Gagnon-Audet, AA; Martin, J; Poirier, P; Simard, S; Turcotte, H | 1 |
| Chang, CH; Cohn, LA; Dodam, JR; Reinero, CR | 1 |
| Hattori, T; Hizawa, N; Huang, SK; Isada, A; Konno, S; Nishimura, M; Shijubo, N; Shimizu, K; Taniguchi, N | 1 |
| Armstrong, B; Chung, KF; Corris, PA; Cox, G; Laviolette, M; Niven, RM; Pavord, ID; Shargill, NS; Thomson, NC | 1 |
| Boudewijn, IM; Postma, DS; Schiphof, L; Telenga, ED; Ten Hacken, NH; van den Berge, M; van der Molen, T; van der Wiel, E | 1 |
| Noble, PB | 1 |
| Golding, J; Henderson, J; Miller, LL; Northstone, K; Pembrey, M | 1 |
| Boyd, RL; Heng, TS; Khong, SM; Mathias, LJ; Payne, NL; Siatskas, C; Spyroglou, L; Thorburn, AN | 1 |
| Barranco, P; Bobolea, I; Cancelliere, N; López-Carrasco, V; López-Serrano, C; Quirce, S | 1 |
| Leuppi, JD | 1 |
| Bourke, JE; Donovan, C; FitzPatrick, M | 1 |
| Bjermer, L; Svensson, H; Tufvesson, E | 1 |
| Carlier, V; De Vooght, V; Devos, FC; Haenen, S; Hoet, PH; Nemery, B; Vanoirbeek, JA; Verbeken, E | 1 |
| Lotz, MT; Moore, ML; Peebles, RS | 1 |
| Cardoso, WV; Chen, F; Cruikshank, WW; Fine, A; Kim, YK; Marquez, H; Qian, J; Quadro, L; Shao, F | 1 |
| Brueggemann, LI; Byron, KL; Cribbs, LL; Haick, JM; Neuburg, S; Randhawa, D; Tate, S | 1 |
| Balgoma, D; Billing, B; Daham, K; Dahlén, B; Dahlén, SE; FitzGerald, GA; Henriksson, E; James, A; Kupczyk, M; Lindeberg, A; Wheelock, CE | 1 |
| Cho, SH; Jung, JW; Kang, HR; Min, KU; Park, HK | 1 |
| Castro, M; Holbrook, JT; Irvin, CG; Kaminsky, DA; Shade, D; Sugar, EA; Sumino, K; Wei, CY; Wise, RA | 2 |
| Bush, A; Chaudry, RA; Crowley, S; Rosenthal, M | 2 |
| Gu, W; Mao, S; Shi, Y; Tan, Y | 1 |
| Alcorn, JF; Elloso, MM; Kolls, JK; Mandalapu, S; Manni, ML; Scheller, EV; Trudeau, JB; Wenzel, SE | 1 |
| Beppu, A; Broide, DH; Doherty, TA; Hoffman, HM; McGeough, MD; Miller, M; Mueller, JL; Niwa, M; Pena, CA; Rosenthal, P; Suzukawa, M; Tam, AB | 1 |
| Cho, SH; Jung, JW; Kang, HR; Kim, JY; Kim, SS; Lee, SH | 1 |
| Asai, K; Hirata, K; Kanazawa, H; Kyoh, S; Tochino, Y | 1 |
| Cockcroft, DW; Davis, BE; Martin, AL; Stewart, SL | 2 |
| Anderson, C; Cahir-Mcfarland, E; Carey, V; Damask, A; Duan, QL; Klanderman, BJ; Mariani, TJ; Niu, S; Qiu, W; Raby, BA; Rogers, AJ; Tantisira, KG; Tyagi, S | 1 |
| Bult, W; de Boer, AH; Frijlink, HW; Hagedoorn, P; Lexmond, AJ; ten Hacken, NH; van der Wiel, E | 1 |
| Fedulov, AV; Kobzik, L; Lim, R | 1 |
| Andreani, A; Businarolo, E; Cappiello, G; Giovannini, M; Melara, R; Ribuffo, V; Valli, M | 1 |
| Kajosaari, M; Kalliola, S; Mäkelä, MJ; Malmberg, LP; Mattila, PS; Pelkonen, AS | 1 |
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| Chervinsky, P; Crescenzi, KL; Kellerman, DJ; Liddle, R; Noonan, MJ; Wolfe, J | 1 |
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| Anthonisen, NR; Filuk, RB; Serrette, C | 1 |
| Cockcroft, DW; Gore, BP; Manning, P; Murdock, KY; O'Byrne, PM | 1 |
| Mi, JX | 1 |
| Coutts, C; Higenbottam, T; Jackson, M; Rashdi, T; Stewart, S; Wallwork, J | 1 |
| Boner, AL; De Stefano, G; Vallone, G | 1 |
| Ahmed, T; Ayala, LE | 1 |
| Barnes, PJ; Chung, KF; Nichol, GM; Nix, A | 1 |
| Casanova, JE; Kaufman, J; Riendl, P; Schlueter, DP | 1 |
| Casale, TB; Floerchinger, C; Hunninghake, GW; Richerson, HB; Wood, D; Zehr, BB | 1 |
| Easton, J; Goldberg, B; Lad, P; Meltzer, S | 1 |
| Chiesura-Corona, P; Crescioli, S; De Marzo, N; Fabbri, LM; Mapp, CE; Picotti, G; Tossin, L | 1 |
| Holgate, ST; Lai, CK; Twentyman, OP | 1 |
| Catterall, JR; Douglas, NJ; Flenley, DC; Parker, A; Stewart, IC | 1 |
| Carilli, A; Fairshter, RD; Lin, J; Pai, U; Soriano, A | 1 |
| Adkinson, NF; Eggleston, P; Weiss, ME; Wheeler, B | 1 |
| Larsen, GL; Smith, HR; Wenzel, SE; Westcott, JY | 1 |
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| Hida, W; Ichinose, M; Ishii, M; Sasaki, H; Suzuki, S; Takishima, T | 1 |
| Barnes, PJ; Chung, KF | 1 |
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| Georgopoulos, D; Giulekas, D; Papakosta, D; Sitis, V; Tsakalos, N; Vamvalis, C | 1 |
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| Cushley, MJ; Holgate, ST; Mann, JS | 1 |
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| Chiesura-Corona, P; Dal Vecchio, L; de Marzo, N; di Giacomo, GR; Fabbri, LM; Maestrelli, P; Mapp, CE; Zocca, E | 1 |
| Boschetto, P; Dal Vecchio, L; De Marzo, N; Fabbri, LM; Mapp, CE | 1 |
| Davis, PB; Paget, GL; Simpson, DM; Turi, V | 1 |
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| Brancatisano, M; Brusasco, V; Crimi, E; Crimi, P; Losurdo, E | 2 |
| Bacci, E; Lastrucci, L; Paggiaro, PL; Pardi, F; Rossi, O; Talini, D | 1 |
| Broseghini, C; Di Giacomo, GR; Fabbri, LM; Mapp, CE; Omini, C | 1 |
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| Casale, TB; Donnelly, AL; Rhodes, BJ; Weiler, JM | 1 |
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| Chan-Yeung, M; Lam, S; Leriche, J; Maclean, L | 1 |
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| de Jongste, JC; Kerrebijn, KF; Mons, H; Sterk, PJ; Timmers, MC; Willems, LN | 1 |
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| Ichinose, H; Mezawa, K; Miyamoto, M; Wakabayashi, T | 1 |
| Karvonen, J; Kellomaeki, L; Lahdensuo, A; Muittari, A; Nieminen, MM | 1 |
| Chung, KF; Jeyasingh, K; Snashall, PD | 1 |
| Chetta, A; Corbo, GM; Cuomo, A; Foresi, A; Garavaldi, G; Olivieri, D | 1 |
| Celi, A; Di Pede, F; Giuntini, C; Paggiaro, PL; Paoletti, P; Pistelli, G | 1 |
| Doizoe, T; Handa, M; Horiguchi, T; Konishi, Y; Saga, T; Sakakibara, H; Suetsugu, S; Suzuki, M; Tsuda, M; Umeda, H | 1 |
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| Georgopoulos, D; Giulekas, D; Papakosta, D; Riggos, D; Tsakalos, N; Vamvalis, C | 1 |
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| Bradding, P; Hardy, CC; Holgate, ST; Robinson, C | 2 |
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| Boschetto, P; Dal Vecchio, L; Fabbri, LM; Maestrelli, P; Mapp, CE | 1 |
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| Hopp, RJ; Townley, RJ | 1 |
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| Bonta, IL; de Jongste, JC; Kerrebijn, KF; Mons, H | 1 |
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| Kuroume, T; Mochizuki, H; Morikawa, A; Shigeta, M; Tajima, K; Tokuyama, K | 1 |
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| Chiang, CD; Chung, WC; Huang, WL; Jih, KS; King, SL; Lee, HJ; Lin, TM; Sheu, JY; Yiin, KT | 1 |
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| Barnes, PJ; Dixon, CM; Dollery, CT; Fuller, RW | 1 |
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| Gregg, I | 1 |
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| Austin, DR; Downes, H; Hirshman, CA; Parks, CM | 1 |
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| Fish, JE; Norman, PS | 1 |
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| Britton, J; Tattersfield, AE | 1 |
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| Ciappi, G; Corbo, GM; Foresi, A; Mattoli, S; Patalano, F; Valente, S | 1 |
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| Ciappi, G; Corbo, GM; Foresi, A; Mattoli, S; Sommaruga, A; Verga, A | 1 |
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79 review(s) available for methacholine chloride and Asthma, Bronchial
| Article | Year |
|---|---|
Classification of asthma.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cough; Diagnosis, Differential; Humans; Methacholine Chloride; Spirometry | 2019 |
Diagnostic comparison of methacholine and mannitol bronchial challenge tests for identifying bronchial hyperresponsiveness in asthma: a systematic review and meta-analysis.
Topics: Age Factors; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Humans; Mannitol; Methacholine Chloride; ROC Curve; Sensitivity and Specificity; Sex Factors | 2021 |
Bronchoprovocation tests in asthma: direct versus indirect challenges.
Topics: Asthma; Bronchial Provocation Tests; Histamine; Humans; Mannitol; Methacholine Chloride; Respiratory Hypersensitivity | 2014 |
[Pathophysiology, diagnosis and treatment of cough variant asthma].
Topics: Adrenal Cortex Hormones; Asthma; Cough; Humans; Leukotriene Antagonists; Methacholine Chloride; Prognosis | 2014 |
[Mechanisms of non-specific airway hyperresponsiveness: Methacholine-induced alterations in airway architecture].
Topics: Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Humans; Lung; Methacholine Chloride; Respiratory Hypersensitivity | 2016 |
The role of airway hyperresponsiveness measured by methacholine challenge test in defining asthma severity in asthma-obesity syndrome.
Topics: Animals; Asthma; Disease Progression; Humans; Immunization; Methacholine Chloride; Obesity; Outcome Assessment, Health Care; Severity of Illness Index; Weight Loss | 2016 |
Interpretation of the "positive" methacholine challenge.
Topics: Asthma; Autoimmune Diseases; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Diagnosis, Differential; False Positive Reactions; Gastrointestinal Diseases; Humans; Methacholine Chloride; Occupational Diseases; Respiratory Tract Infections; Sensitivity and Specificity | 2008 |
Small airways disease in asthma.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Aerosols; Airway Resistance; Asthma; Bronchioles; Bronchoconstrictor Agents; Eosinophils; Humans; Inflammation; Lymphocytes; Methacholine Chloride; Pulmonary Alveoli; Tomography, X-Ray Computed | 2008 |
Diagnostic and therapeutic value of airway challenges in asthma.
Topics: Adenosine Monophosphate; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Humans; Mannitol; Methacholine Chloride; Saline Solution, Hypertonic | 2009 |
Leukotriene E4: perspective on the forgotten mediator.
Topics: Animals; Aspirin; Asthma; Bronchial Hyperreactivity; Drug Hypersensitivity; Histamine; Humans; Leukotriene C4; Leukotriene D4; Leukotriene E4; Methacholine Chloride; Receptors, Leukotriene; Skin | 2009 |
Direct and indirect challenges in the clinical assessment of asthma.
Topics: Adenosine Monophosphate; Asthma; Bronchial Provocation Tests; Diagnosis, Differential; Exercise; Humans; Mannitol; Methacholine Chloride; Sensitivity and Specificity | 2009 |
Direct challenge tests: Airway hyperresponsiveness in asthma: its measurement and clinical significance.
Topics: Administration, Inhalation; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Forced Expiratory Volume; Humans; Methacholine Chloride; Predictive Value of Tests; Severity of Illness Index | 2010 |
Indirect challenge tests: Airway hyperresponsiveness in asthma: its measurement and clinical significance.
Topics: Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Exercise Test; Histamine; Humans; Methacholine Chloride; Reproducibility of Results; Severity of Illness Index | 2010 |
Bronchial provocation testing: the future.
Topics: Asthma; Asthma, Exercise-Induced; Bronchial Hyperreactivity; Bronchial Provocation Tests; Clinical Trials as Topic; Exercise Test; Humans; Inflammation Mediators; Mannitol; Methacholine Chloride | 2011 |
[Bronchial challenge tests].
Topics: Allergens; Alveolitis, Extrinsic Allergic; Asthma; Asthma, Occupational; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Contraindications; Humans; Isocyanates; Methacholine Chloride; Predictive Value of Tests; Respiratory Function Tests | 2011 |
Vocal cord dysfunction: what do we know?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Child; Child, Preschool; Diagnosis, Differential; Female; Humans; Infant; Infant, Newborn; Laryngeal Diseases; Laryngoscopy; Male; Methacholine Chloride; Middle Aged; Plethysmography; Pulmonary Medicine; Vocal Cords | 2011 |
Cough variant asthma: lessons learned from deep inspirations.
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cough; Eosinophils; Humans; Inflammation; Inhalation; Methacholine Chloride | 2012 |
Past, present and future uses of methacholine testing.
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; History, 20th Century; History, 21st Century; Humans; Lung; Methacholine Chloride; Predictive Value of Tests; Prognosis; Severity of Illness Index | 2012 |
Peripheral lung responsiveness assessed by forced oscillations through the wedged bronchoscope.
Topics: Asthma; Bronchoconstrictor Agents; Bronchoscopy; Chest Wall Oscillation; Humans; Lung; Methacholine Chloride; Pulmonary Wedge Pressure | 2003 |
Bronchoprovocation methods: direct challenges.
Topics: Administration, Inhalation; Asthma; Bronchial Provocation Tests; Histamine; Humans; Methacholine Chloride; Nebulizers and Vaporizers; Practice Guidelines as Topic; Sensitivity and Specificity | 2003 |
What evidence implicates airway smooth muscle in the cause of BHR?
Topics: Actins; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Elasticity; Histamine; Humans; Methacholine Chloride; Muscle, Smooth; Respiration | 2003 |
Airway hyperresponsiveness: a story of mice and men and cytokines.
Topics: Adrenergic beta-Agonists; Amino Acid Sequence; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Forced Expiratory Volume; Humans; Interleukin-1; Interleukin-13; Interleukin-13 Receptor alpha1 Subunit; Macrophages, Alveolar; Methacholine Chloride; Molecular Sequence Data; Mutation; Neutrophils; Polymorphism, Genetic; Receptors, Adrenergic, beta; Receptors, Interleukin; Receptors, Interleukin-13; Tumor Necrosis Factor-alpha | 2003 |
Bronchodilation and bronchoprotection by deep inspiration and their relationship to bronchial hyperresponsiveness.
Topics: Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Humans; Lung; Methacholine Chloride; Respiration; Rhinitis | 2003 |
Leukotriene C4 synthase polymorphisms and responsiveness to leukotriene antagonists in asthma.
Topics: Adenosine Monophosphate; Asthma; Bronchi; Bronchial Provocation Tests; Bronchodilator Agents; Cross-Over Studies; Forced Expiratory Volume; Glutathione Transferase; Humans; Leukotriene Antagonists; Methacholine Chloride; Polymorphism, Genetic; Randomized Controlled Trials as Topic; Retrospective Studies | 2003 |
Airway hyperresponsiveness in asthma: geometry is not everything!
Topics: Asthma; Biomechanical Phenomena; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Humans; Inflammation; Methacholine Chloride; Muscle, Smooth; Reproducibility of Results; Respiratory Mucosa; Severity of Illness Index | 2003 |
Cytokine-directed therapies for the treatment of chronic airway diseases.
Topics: Adrenal Cortex Hormones; Animals; Asthma; Chemokines; Cytokines; Humans; Inflammation; Interferons; Interleukin-10; Interleukin-12; Interleukin-13; Interleukin-4; Interleukin-5; Interleukin-9; Methacholine Chloride; Models, Biological; Neutrophils; Pulmonary Disease, Chronic Obstructive; Th2 Cells; Time Factors | 2003 |
Direct or indirect stimuli for bronchial challenge testing: what is the relevance for asthma epidemiology?
Topics: Adenosine; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Histamine; Humans; Methacholine Chloride; Predictive Value of Tests; Prevalence | 2004 |
Obesity, allergy and immunology.
Topics: Adult; Animals; Asthma; Body Weight; Bronchial Provocation Tests; Child; Cytokines; Female; Humans; Methacholine Chloride; Obesity | 2005 |
Investigative bronchoprovocation and bronchoscopy in airway diseases.
Topics: Asthma; Biopsy; Bronchi; Bronchial Provocation Tests; Bronchoalveolar Lavage; Bronchoconstrictor Agents; Bronchoscopy; Forced Expiratory Volume; Humans; Lung Diseases; Methacholine Chloride; Pulmonary Disease, Chronic Obstructive | 2005 |
Airbag asthma: a case report and review of the literature.
Topics: Accidents, Traffic; Air Bags; Asthma; Humans; Inhalation Exposure; Male; Methacholine Chloride; Middle Aged; Skin Tests | 2006 |
The bronchoprotective effect of inhaling methacholine by using total lung capacity inspirations has a marked influence on the interpretation of the test result.
Topics: Administration, Inhalation; Asthma; Bronchoconstrictor Agents; Humans; Methacholine Chloride; Reproducibility of Results; Total Lung Capacity | 2006 |
Non-invasive measurement of airway inflammation in asthma.
Topics: Adenosine Monophosphate; Asthma; Biomarkers; Breath Tests; Bronchial Hyperreactivity; Eosinophil Cationic Protein; Eosinophils; Exercise; Humans; Inflammation; Leukotrienes; Mannitol; Methacholine Chloride; Nitric Oxide | 2006 |
Cough and asthma.
Topics: Adrenal Cortex Hormones; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bronchodilator Agents; Cough; Disease Progression; Humans; Methacholine Chloride; Pneumonia | 2007 |
Methacholine challenge testing: identifying its diagnostic role, testing, coding, and reimbursement.
Topics: Asthma; Bronchial Provocation Tests; Forms and Records Control; Humans; Insurance, Health, Reimbursement; Methacholine Chloride; Sensitivity and Specificity; Spirometry | 2007 |
Provocative challenges to help diagnose and monitor asthma: exercise, methacholine, adenosine, and mannitol.
Topics: Adenosine; Adolescent; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Child, Preschool; Exercise; Humans; Mannitol; Methacholine Chloride; Respiratory Function Tests | 2008 |
Genetic differences in airway smooth muscle function.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Contractile Proteins; Genetic Predisposition to Disease; Humans; Methacholine Chloride; Muscle Contraction; Muscle Relaxation; Muscle, Smooth | 2008 |
When should a methacholine challenge be ordered for a patient with suspected asthma?
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Diagnosis, Differential; Health Status Indicators; Humans; Methacholine Chloride | 2008 |
Ventilatory control in asthma.
Topics: Adrenergic beta-Agonists; Aminophylline; Analgesics; Asthma; Bronchial Provocation Tests; Carbon Dioxide; Chemoreceptor Cells; Consciousness; Humans; Hypnotics and Sedatives; Mechanoreceptors; Methacholine Chloride; Methacholine Compounds; Pulmonary Gas Exchange; Respiration; Theophylline | 1984 |
The clinical value of pharmacologic bronchoprovocation challenge.
Topics: Adolescent; Adult; Asthma; Bronchi; Bronchial Provocation Tests; Child; Dose-Response Relationship, Drug; Forced Expiratory Volume; Histamine; Humans; Methacholine Chloride; Methacholine Compounds; Muscle, Smooth; Respiratory Sounds | 1984 |
Influence of leukotriene antagonists on baseline pulmonary function and asthmatic responses.
Topics: Antigens; Asthma; Bronchial Diseases; Cold Temperature; Constriction, Pathologic; Exercise; Histamine; Humans; Leukotriene Antagonists; Lung; Methacholine Chloride | 1994 |
[Non-allergenic bronchial hyperreactivity. Measurement methods and reproducibility].
Topics: Administration, Inhalation; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Calibration; Dose-Response Relationship, Drug; Evaluation Studies as Topic; Exercise; Histamine; Humans; Hyperventilation; Lung Volume Measurements; Methacholine Chloride; Reproducibility of Results; Sensitivity and Specificity | 1994 |
Is airways hyperreactivity selective or non-selective?
Topics: Allergens; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Histamine; Humans; Methacholine Chloride | 1993 |
[Methods of interpreting pulmonary gas exchange].
Topics: Animals; Asthma; Dogs; Humans; Methacholine Chloride; Methods; Pulmonary Gas Exchange; Ventilation-Perfusion Ratio | 1993 |
[Non-specific bronchial hyperreactivity: epidemiological aspects and clinical significance].
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Forced Expiratory Volume; Humans; Methacholine Chloride | 1993 |
Bronchial inhalation challenge procedures with allergens and other bronchoconstrictor substances.
Topics: Allergens; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Histamine; Humans; Methacholine Chloride; Time Factors | 1996 |
[Function testing of bronchial responsiveness].
Topics: Acetylcholine; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Histamine; Humans; Methacholine Chloride | 1996 |
[Function testing of bronchial responsiveness].
Topics: Acetylcholine; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Histamine; Humans; Methacholine Chloride | 1997 |
Bronchial challenge testing.
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Diagnosis, Differential; Female; Humans; Male; Methacholine Chloride; Sensitivity and Specificity | 1995 |
Testing airway responsiveness using inhaled methacholine or histamine.
Topics: Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Child, Preschool; Female; Histamine; Humans; Male; Methacholine Chloride; Reproducibility of Results; Sensitivity and Specificity | 1997 |
Long-acting inhaled beta 2-agonists and the loss of "bronchoprotective" efficacy.
Topics: Adrenergic beta-Agonists; Asthma; Bronchoconstrictor Agents; Bronchodilator Agents; Ethanolamines; Formoterol Fumarate; Humans; Methacholine Chloride; Terbutaline | 1998 |
Problems and progress in measuring methacholine bronchial reactivity.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Humans; Methacholine Chloride | 1998 |
Inhaled beta2-agonists and airway responses to allergen.
Topics: Adenosine Monophosphate; Administration, Inhalation; Adrenergic beta-Agonists; Albuterol; Allergens; Asthma; Bronchoconstriction; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Drug Tolerance; Forced Expiratory Volume; Humans; Methacholine Chloride; Randomized Controlled Trials as Topic; Salmeterol Xinafoate; Terbutaline; Time Factors | 1998 |
Effect of inhaled corticosteroids on bronchial responsiveness in patients with "corticosteroid naive" mild asthma: a meta-analysis.
Topics: Administration, Inhalation; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Drug Administration Schedule; Glucocorticoids; Histamine; Humans; Methacholine Chloride | 1999 |
Challenge tests to assess airway hyperresponsiveness and efficacy of drugs used in the treatment of asthma.
Topics: Aerosols; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Histamine; Humans; Methacholine Chloride; Saline Solution, Hypertonic | 1996 |
Airway inflammation in asthma and chronic obstructive pulmonary disease with special emphasis on the antigen-presenting dendritic cell: influence of treatment with fluticasone propionate.
Topics: Androstadienes; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dendritic Cells; Dose-Response Relationship, Drug; Fluticasone; Forced Expiratory Volume; Humans; Lung Diseases, Obstructive; Methacholine Chloride | 1999 |
New millennium bronchodilators for asthma: single-isomer beta agonists.
Topics: Adrenergic beta-Agonists; Albuterol; Asthma; Bronchi; Bronchoconstrictor Agents; Bronchodilator Agents; Eosinophils; Ethanolamines; Exudates and Transudates; Forced Expiratory Volume; Formoterol Fumarate; Histamine Release; Humans; Isomerism; Methacholine Chloride; Neutrophils; Proteins | 2000 |
Bronchial hyperresponsiveness and its relationship to asthma in childhood.
Topics: Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Child, Preschool; Disease Susceptibility; Environmental Exposure; Forced Expiratory Volume; Histamine; Humans; Hypersensitivity, Immediate; Infant; Methacholine Chloride; New Zealand; Prognosis; Reproducibility of Results; Respiratory System; Respiratory Tract Infections; Sensitivity and Specificity; Tidal Volume; Tobacco Smoke Pollution; Treatment Outcome | 1993 |
Spirometry and tests of bronchial hyperresponsiveness in population studies.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Histamine; Humans; Methacholine Chloride; Occupational Diseases; Respiratory Function Tests; Spirometry | 2000 |
Drug treatment of airway inflammation in asthma.
Topics: Administration, Inhalation; Airway Resistance; Allergens; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Humans; Methacholine Chloride; Muscle, Smooth | 2001 |
Tidal breathing affects airway responsiveness to methacholine.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Humans; Inflammation; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Tidal Volume | 2001 |
[Bronchodilator effect of salmeterol and inhibition of bronchial hyperreactivity].
Topics: Adrenergic beta-Agonists; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchodilator Agents; Clinical Trials as Topic; Humans; Methacholine Chloride; Salmeterol Xinafoate; Time Factors | 1992 |
Antihistamines and allergic asthma.
Topics: Asthma; Bronchial Spasm; Histamine H1 Antagonists; Humans; Methacholine Chloride; Physical Exertion; Receptors, Histamine H2 | 1991 |
Bronchoprovocation in children.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Cold Temperature; Exercise Test; Histamine; Humans; Hyperventilation; Methacholine Chloride; Nebulizers and Vaporizers; Sodium Chloride; Water | 1991 |
Sulphidopeptide leukotrienes in asthma.
Topics: Animals; Aspirin; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Guinea Pigs; Histamine; Humans; Leukotriene E4; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; SRS-A; Trachea | 1991 |
[Efficacy and long-term tolerance of beta-2 adrenergic stimulants].
Topics: Adrenergic beta-Agonists; Airway Obstruction; Asthma; Bronchodilator Agents; Drug Tolerance; Humans; Methacholine Chloride; Methacholine Compounds; Time Factors | 1990 |
Hyperresponsiveness as a determinant of the outcome in childhood asthma.
Topics: Asthma; Bronchi; Child; Child, Preschool; Forced Expiratory Volume; Humans; Methacholine Chloride; Prognosis; Time Factors | 1991 |
The clinical value of pharmacologic bronchoprovocation challenge.
Topics: Asthma; Bronchial Provocation Tests; Histamine; Humans; Methacholine Chloride; Methacholine Compounds | 1990 |
The relationship between mast cell-mediator release and bronchial reactivity in allergic asthma.
Topics: Adult; Airway Obstruction; Asthma; Bronchial Provocation Tests; Chemotaxis, Leukocyte; Forced Expiratory Volume; Histamine Release; Humans; Mast Cells; Methacholine Chloride; Methacholine Compounds; Neutrophils | 1987 |
[Calcium inhibitors in asthma].
Topics: Asthma; Asthma, Exercise-Induced; Calcium Channel Blockers; Histamine; Histamine Release; Humans; Methacholine Chloride; Methacholine Compounds; Receptors, Drug; Receptors, Immunologic | 1987 |
[Bronchial adrenergic receptors and asthma. Tachyphylaxis and its prevention].
Topics: Adrenal Cortex Hormones; Asthma; Bronchi; Humans; Ketotifen; Methacholine Chloride; Methacholine Compounds; Receptors, Adrenergic, beta; Sympathomimetics; Tachyphylaxis | 1988 |
Calcium, calcium channel blockade and airways function.
Topics: Adrenergic beta-Agonists; Allergens; Angina Pectoris; Animals; Asthma; Bronchi; Calcium; Calcium Channel Blockers; Cold Temperature; Drug Interactions; Histamine; Humans; Hypertension; In Vitro Techniques; Mast Cells; Methacholine Chloride; Methacholine Compounds; Mucus; Muscle Contraction; Muscle, Smooth; Physical Exertion; Respiratory Physiological Phenomena; Respiratory System | 1986 |
Anti-cholinergic agents and their use in asthma.
Topics: Allergens; Asthma; Atropine Derivatives; Bronchial Provocation Tests; Bronchial Spasm; Histamine; Humans; Ipratropium; Methacholine Chloride; Methacholine Compounds; Parasympatholytics; Physical Exertion | 1988 |
Bronchial hyperresponsiveness is not bronchial hyperresponsiveness is not bronchial asthma.
Topics: Acetylcholine; Adenosine; Airway Resistance; Animals; Asthma; Bronchi; Histamine; Humans; Methacholine Chloride; Methacholine Compounds; Neuropeptides | 1988 |
In-vivo and in-vitro responsiveness of bronchial smooth muscle.
Topics: Airway Resistance; Albuterol; Animals; Asthma; Atropine; Atropine Derivatives; Bronchi; Carbachol; Dose-Response Relationship, Drug; Histamine; Humans; In Vitro Techniques; Methacholine Chloride; Methacholine Compounds; Muscle Contraction; Muscle, Smooth; Serotonin; Trachea | 1986 |
Does measurement of bronchial hyperreactivity help in the clinical diagnosis of asthma?
Topics: Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Histamine; Humans; Lung Diseases, Obstructive; Methacholine Chloride; Methacholine Compounds; Reference Values; Smoking | 1986 |
Asthma and the role of inflammation.
Topics: Airway Resistance; Asthma; Humans; Inflammation; Methacholine Chloride; Methacholine Compounds; Muscle Contraction; Occupational Diseases; Seasons | 1986 |
The pathology of obstructive and inflammatory airway diseases.
Topics: Animals; Asthma; Bronchi; Bronchiectasis; Bronchiolitis, Viral; Bronchitis; Child; Dogs; Humans; Lung; Methacholine Chloride; Methacholine Compounds; Mucus; Status Asthmaticus; Sulfur Dioxide; Viscosity | 1986 |
The origin of airway hyperresponsiveness.
Topics: Allergens; Asthma; Autonomic Nervous System; Epithelium; Histamine; Humans; Methacholine Chloride; Methacholine Compounds; Muscle, Smooth; Permeability; Pulmonary Ventilation; Respiratory Hypersensitivity; Time Factors | 1986 |
Bronchial inhalation tests. I. Measurement of nonallergic bronchial responsiveness.
Topics: Administration, Intranasal; Aerosols; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Dose-Response Relationship, Drug; Histamine; Humans; Methacholine Chloride; Methacholine Compounds; Occupational Diseases | 1985 |
569 trial(s) available for methacholine chloride and Asthma, Bronchial
| Article | Year |
|---|---|
Bronchial provocation test measured by using the forced oscillation technique to assess airway responsiveness.
Topics: Asthma; Bronchial Provocation Tests; Forced Expiratory Volume; Humans; Methacholine Chloride; Respiratory System | 2021 |
Effect of daily dosing with tiotropium against methacholine induced bronchoconstriction in asthmatics.
Topics: Administration, Inhalation; Adult; Asthma; Bronchoconstriction; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Humans; Methacholine Chloride; Muscarinic Antagonists; Receptors, Muscarinic; Tiotropium Bromide | 2022 |
Impact of airway challenges on cardiovascular risk in asthma - a randomized controlled trial.
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstriction; Cardiovascular Diseases; Forced Expiratory Volume; Humans; Methacholine Chloride; Pulse Wave Analysis; Risk Factors | 2023 |
FEV
Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Anti-Asthmatic Agents; Asthma; Cross-Over Studies; Drug Delivery Systems; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Middle Aged | 2020 |
Airway hyperresponsiveness, remodeling and inflammation in infants with wheeze.
Topics: Airway Remodeling; Asthma; Eosinophils; Female; Humans; Infant; Inflammation; Male; Methacholine Chloride; Muscle, Smooth; Respiratory Sounds | 2020 |
[Leukotriene D4 bronchial provocation test for detection of airway hyper-responsiveness in children].
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Child; Humans; Leukotriene D4; Methacholine Chloride; Respiratory Hypersensitivity | 2020 |
Two-minute tidal breathing methacholine bronchial challenge: Comparison of two jet nebulisers.
Topics: Asthma; Bronchial Provocation Tests; Forced Expiratory Volume; Humans; Methacholine Chloride; Nebulizers and Vaporizers | 2021 |
KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cell Count; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Imatinib Mesylate; Male; Mast Cells; Methacholine Chloride; Middle Aged; Protein Kinase Inhibitors; Quality of Life; Tryptases | 2017 |
Clinical Implications of Oscillatory Lung Function during Methacholine Bronchoprovocation Testing of Preschool Children.
Topics: Asthma; Bronchial Provocation Tests; Child, Preschool; Female; Humans; Male; Methacholine Chloride; Respiratory Mechanics | 2017 |
Circulating microRNAs and association with methacholine PC20 in the Childhood Asthma Management Program (CAMP) cohort.
Topics: Asthma; Cell Proliferation; Cell Size; Child; Cohort Studies; Confidence Intervals; Female; Humans; Least-Squares Analysis; Linear Models; Lung; Male; Methacholine Chloride; MicroRNAs; Myocytes, Smooth Muscle; Reproducibility of Results; Software | 2017 |
The effect of glycopyrronium and indacaterol, as monotherapy and in combination, on the methacholine dose-response curve of mild asthmatics: a randomized three-way crossover study.
Topics: Adolescent; Adrenergic beta-2 Receptor Agonists; Adult; Aged; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Drug Combinations; Female; Forced Expiratory Volume; Glycopyrrolate; Humans; Indans; Lung; Male; Methacholine Chloride; Middle Aged; Muscarinic Antagonists; Quinolones; Saskatchewan; Severity of Illness Index; Time Factors; Treatment Outcome; Vital Capacity; Young Adult | 2017 |
The use of methacholine provocation when assessing therapeutic equivalence between two inhalers in asthmatic patients.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers; Outcome Assessment, Health Care; Therapeutic Equivalency | 2018 |
Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma.
Topics: Administration, Intravenous; Adult; Aldehyde Oxidoreductases; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Placebos; Proof of Concept Study; Pyrroles; S-Nitrosoglutathione; Treatment Outcome; Young Adult | 2018 |
Bronchoprotective effect of vilanterol against methacholine-induced bronchoconstriction in mild asthmatics: A randomized three-way crossover study.
Topics: Adrenergic beta-2 Receptor Agonists; Androstadienes; Asthma; Benzyl Alcohols; Bronchoconstriction; Bronchodilator Agents; Chlorobenzenes; Cross-Over Studies; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride | 2018 |
Airway responsiveness to adenosine after a single dose of fluticasone propionate discriminates asthma from COPD.
Topics: Adenosine Monophosphate; Administration, Inhalation; Adult; Aged; Androstadienes; Asthma; Bronchial Hyperreactivity; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Female; Fluticasone; Humans; Male; Methacholine Chloride; Middle Aged; Pulmonary Disease, Chronic Obstructive; Sensitivity and Specificity | 2014 |
Proof-of-concept evaluation of trough airway hyper-responsiveness following regular racemic or levosalbutamol in genotype-stratified steroid-treated persistent asthmatic patients.
Topics: Administration, Inhalation; Adolescent; Adrenergic beta-2 Receptor Agonists; Adult; Aged; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Female; Genotype; Humans; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Young Adult | 2014 |
Low-dose salbutamol suppresses airway responsiveness to histamine but not methacholine in subjects with asthma.
Topics: Administration, Inhalation; Adolescent; Adrenergic beta-2 Receptor Agonists; Adult; Aged; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Cross-Over Studies; Female; Histamine; Humans; Male; Methacholine Chloride; Middle Aged; Young Adult | 2013 |
Refractoriness to inhaled mannitol 3 hours after allergen challenge.
Topics: Administration, Inhalation; Adult; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Hypersensitivity; Male; Mannitol; Methacholine Chloride; Young Adult | 2013 |
Influence of cardiac dysfunction and systemic inflammation on pulmonary function and airway responsiveness in obese subjects.
Topics: Adult; Aged; Asthma; Blood Glucose; Bronchoconstrictor Agents; C-Reactive Protein; Female; Heart Diseases; Heart Rate; Humans; Inflammation; Lipids; Male; Methacholine Chloride; Middle Aged; Natriuretic Peptide, Brain; Obesity; Respiratory Function Tests | 2013 |
Comparison of direct and indirect bronchoprovocation testing using ventilator-acquired pulmonary mechanics in healthy cats and cats with experimental allergic asthma.
Topics: Adenosine Monophosphate; Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cat Diseases; Cats; Cross-Over Studies; Lung; Mannitol; Methacholine Chloride | 2013 |
Safety of bronchial thermoplasty in patients with severe refractory asthma.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Albuterol; Androstadienes; Asthma; Bronchi; Bronchodilator Agents; Bronchoscopy; Catheter Ablation; Female; Fluticasone; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Salmeterol Xinafoate; Young Adult | 2013 |
Effects of selective COX-2 inhibition on allergen-induced bronchoconstriction and airway inflammation in asthma.
Topics: Adult; Allergens; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Eosinophils; Etoricoxib; Female; Forced Expiratory Volume; Humans; Inflammation; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Prostaglandins; Pyridines; Sputum; Sulfones | 2014 |
Variability of methacholine bronchoprovocation and the effect of inhaled corticosteroids in mild asthma.
Topics: Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Androstadienes; Asthma; Bronchial Provocation Tests; Child; Cross-Over Studies; Diagnostic Errors; Disease Progression; Dose-Response Relationship, Drug; Female; Fluticasone; Humans; Male; Methacholine Chloride; Middle Aged; Reproducibility of Results; Young Adult | 2014 |
Low levels of fractional exhaled nitric oxide and deep inhalation bronchoprotection are associated with mannitol non-responsiveness in asthma.
Topics: Adolescent; Adult; Aged; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Inhalation; Male; Mannitol; Methacholine Chloride; Middle Aged; Nitric Oxide; Powders; Young Adult | 2014 |
Response--dose ratio is a surrogate of cumulative provocative dosage for bronchial provocation tests in asthma.
Topics: Adult; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchodilator Agents; China; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Leukotriene D4; Lung; Male; Methacholine Chloride; Middle Aged; Predictive Value of Tests; Vital Capacity | 2014 |
Dependence of bronchoconstrictor and bronchodilator responses on thoracic gas compression volume.
Topics: Adult; Aged; Albuterol; Asthma; Body Height; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Plethysmography; Pulmonary Disease, Chronic Obstructive; Reproducibility of Results; Sex Factors; Spirometry; Total Lung Capacity | 2014 |
Responsiveness to methacholine, but not leukotriene D4, correlates with fractional exhaled nitric oxide in asthma.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Female; Humans; Leukotriene D4; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Treatment Outcome | 2016 |
Provocative dose of methacholine causing a 20% drop in FEV1 should be used to interpret methacholine challenge tests with modern nebulizers.
Topics: Administration, Inhalation; Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Child, Preschool; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Nebulizers and Vaporizers | 2015 |
Airway responsiveness to mannitol 24 h after allergen challenge in atopic asthmatics.
Topics: Administration, Inhalation; Adult; Allergens; Asthma; Breath Tests; Bronchi; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Male; Mannitol; Methacholine Chloride; Nitric Oxide; Young Adult | 2015 |
Effects of weight loss on airway responsiveness in obese adults with asthma: does weight loss lead to reversibility of asthma?
Topics: Adult; Asthma; Body Mass Index; Bronchial Provocation Tests; Comorbidity; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Obesity; Prospective Studies; Quality of Life; Respiratory Hypersensitivity; Severity of Illness Index; Treatment Outcome; Vital Capacity; Weight Loss | 2015 |
Comparison of the provocative concentration of methacholine causing a 20% fall in FEV1 between the AeroEclipse II breath-actuated nebulizer and the wright nebulizer in adult subjects with asthma.
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Over Studies; Female; Humans; Male; Methacholine Chloride; Nebulizers and Vaporizers; Young Adult | 2015 |
Fluticasone propionate in clinically suspected asthma patients with negative methacholine challenge test.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Female; Fluticasone; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers; Nitric Oxide | 2017 |
Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways.
Topics: Adult; Airway Resistance; Antioxidants; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Gene Expression Regulation; Humans; Isothiocyanates; Lung; Lung Volume Measurements; Male; Methacholine Chloride; Middle Aged; NF-E2-Related Factor 2; Predictive Value of Tests; Sulfoxides; Time Factors; Tomography, Spiral Computed; Treatment Outcome; Young Adult | 2015 |
Bioassay of salmeterol in children using methacholine challenge with impulse oscillometry.
Topics: Administration, Inhalation; Airway Resistance; Asthma; Biological Assay; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Child, Preschool; Cross-Over Studies; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Oscillometry; Prospective Studies; Salmeterol Xinafoate; Single-Blind Method; Therapeutic Equivalency | 2016 |
Methacholine challenge testing is superior to the exercise challenge for detecting asthma in children.
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Exercise Test; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Predictive Value of Tests | 2015 |
A pilot randomized controlled trial of pioglitazone for the treatment of poorly controlled asthma in obesity.
Topics: Adult; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Double-Blind Method; Female; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Obesity; Pilot Projects; Pioglitazone; Risk Factors; Thiazolidinediones; Time Factors; Treatment Outcome; Vermont; Weight Gain | 2015 |
Impulse Oscillometry as a Predictor of Asthma Exacerbations in Young Children.
Topics: Asthma; Child; Child, Preschool; Cross-Sectional Studies; Female; Forced Expiratory Volume; Humans; Logistic Models; Male; Methacholine Chloride; Oscillometry; Predictive Value of Tests; Prospective Studies; Skin Tests; Symptom Flare Up; Vital Capacity | 2016 |
[The Safety and efficacy of airway-hyperresponsiveness test for asthma using by SK-1211 (Methacholine Chloride)].
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Child; Female; Humans; Male; Methacholine Chloride; Young Adult | 2016 |
Fluticasone/formoterol association favors long-lasting decrease in bronchial reactivity to methacholine and weekly PEF variability.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Adult; Asthma; Bronchoconstrictor Agents; Bronchodilator Agents; Female; Fluticasone; Formoterol Fumarate; Humans; Male; Methacholine Chloride; Peak Expiratory Flow Rate | 2016 |
Duration of bronchoprotection of the long-acting muscarinic antagonists tiotropium & glycopyrronium against methacholine-induced bronchoconstriction in mild asthmatics.
Topics: Adult; Aged; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Cholinergic Antagonists; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Glycopyrrolate; Guidelines as Topic; Humans; Male; Methacholine Chloride; Muscarinic Antagonists; Tiotropium Bromide | 2016 |
The interaction between bronchoconstriction and cough in asthma.
Topics: Adult; Asthma; Bronchoconstriction; Capsaicin; Cough; Cross-Over Studies; Female; Humans; Male; Methacholine Chloride; Single-Blind Method; Young Adult | 2017 |
The PD
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride | 2017 |
Comparison of the protective effect amongst anticholinergic drugs on methacholine-induced bronchoconstriction in asthma.
Topics: Administration, Inhalation; Adult; Analysis of Variance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cholinergic Antagonists; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Forced Expiratory Volume; Humans; Ipratropium; Male; Methacholine Chloride; Premedication; Probability; Reference Values; Respiratory Function Tests; Scopolamine Derivatives; Sensitivity and Specificity; Severity of Illness Index; Tiotropium Bromide; Treatment Outcome | 2008 |
Comparison of N-epsilon-(Carboxymethyl)Lysine levels and percentage of eosinophils in induced sputum for assessment of small airway involvements in asthma.
Topics: Adult; Aged; Asthma; Case-Control Studies; Eosinophils; Female; Forced Expiratory Volume; Humans; Lysine; Male; Methacholine Chloride; Middle Aged; Respiratory System; Sputum | 2008 |
Differences in the response to methacholine between the tidal breathing and dosimeter methods: influence of the dose of bronchoconstrictor agent delivered to the mouth.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cohort Studies; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Nebulizers and Vaporizers; Predictive Value of Tests; Tidal Volume | 2008 |
Breathing exercises for asthma: a randomised controlled trial.
Topics: Adult; Aged; Asthma; Breathing Exercises; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Hyperventilation; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Quality of Life; Single-Blind Method; Sputum; Treatment Outcome | 2009 |
Efficacy and safety of ciclesonide once daily and fluticasone propionate twice daily in children with asthma.
Topics: Androstadienes; Anti-Asthmatic Agents; Asthma; Bronchoconstrictor Agents; Child; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fluticasone; Forced Expiratory Volume; Humans; Hydrocortisone; Lung; Male; Methacholine Chloride; Pregnenediones; Quality of Life; Treatment Outcome | 2009 |
Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma.
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Child; Exercise Test; Female; Forced Expiratory Volume; Humans; Male; Mannitol; Methacholine Chloride; Middle Aged; Predictive Value of Tests; Sensitivity and Specificity; United States; Young Adult | 2009 |
Single-dose desloratadine and montelukast and allergen-induced late airway responses.
Topics: Acetates; Adult; Allergens; Analysis of Variance; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Cross-Over Studies; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Eosinophils; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Leukotriene Antagonists; Loratadine; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Placebos; Quinolines; Respiratory Function Tests; Sputum; Sulfides; Treatment Outcome | 2009 |
Effects of ciclesonide and fluticasone on cortisol secretion in patients with persistent asthma.
Topics: Adenosine; Adolescent; Adult; Aged; Albuterol; Analysis of Variance; Androstadienes; Anti-Allergic Agents; Area Under Curve; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Female; Fluticasone; Forced Expiratory Volume; Humans; Hydrocortisone; Least-Squares Analysis; Male; Methacholine Chloride; Middle Aged; Placebos; Pregnenediones; Salmeterol Xinafoate; Spirometry; Treatment Outcome | 2009 |
Maximal response plateau to adenosine 5'-monophosphate in asthma. Relationship with the response to methacholine, exhaled nitric oxide, and exhaled breath condensate pH.
Topics: Adenosine Monophosphate; Administration, Inhalation; Adult; Asthma; Breath Tests; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cohort Studies; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Hydrogen-Ion Concentration; Male; Maximum Tolerated Dose; Methacholine Chloride; Middle Aged; Nitric Oxide; Probability; Sensitivity and Specificity; Severity of Illness Index; Spirometry | 2009 |
The natural history of methacholine responsivenesss in the CAMP study: who becomes unresponsive?
Topics: Adolescent; Age Factors; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Follow-Up Studies; Humans; Methacholine Chloride; Patient Selection; Sex Factors; Young Adult | 2009 |
Effect of inhaled corticosteroids on small airways in asthma: investigation using impulse oscillometry.
Topics: Adrenal Cortex Hormones; Adult; Airway Resistance; Asthma; Beclomethasone; Chlorofluorocarbons; Double-Blind Method; Female; Humans; Hydrocarbons, Fluorinated; Lung Volume Measurements; Male; Methacholine Chloride; Middle Aged; Muscarinic Agonists; Nebulizers and Vaporizers; Oscillometry; Respiratory Function Tests; Respiratory System; Spirometry | 2009 |
The bronchial response to mannitol is attenuated by a previous methacholine test: but not vice versa.
Topics: Administration, Inhalation; Adolescent; Adult; Aged; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Humans; Interviews as Topic; Male; Mannitol; Methacholine Chloride; Middle Aged; Surveys and Questionnaires; Young Adult | 2009 |
Duration of bronchoprotection of inhaled ipratropium against inhaled methacholine.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Forced Expiratory Volume; Humans; Ipratropium; Male; Methacholine Chloride; Muscarinic Agonists; Muscarinic Antagonists; Time Factors | 2009 |
Methacholine challenge--comparison of an ATS protocol to a new rapid single concentration technique.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers; Regression Analysis; Young Adult | 2009 |
Time-dependent effects of inhaled corticosteroids on lung function, bronchial hyperresponsiveness, and airway inflammation in asthma.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Anti-Allergic Agents; Anti-Inflammatory Agents; Asthma; Breath Tests; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Hydrogen-Ion Concentration; Inflammation; Lung; Male; Methacholine Chloride; Middle Aged; Mometasone Furoate; Nitrates; Nitric Oxide; Pregnadienediols; Young Adult | 2009 |
Clinical application of exhaled breath condensate analysis in asthma: prediction of FEV1 improvement by steroid therapy.
Topics: Adrenergic beta-2 Receptor Agonists; Adult; Androstadienes; Asthma; Breath Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Cytokines; Fluticasone; Forced Expiratory Volume; Humans; Methacholine Chloride; Predictive Value of Tests | 2009 |
Comparison of methacholine and adenosine inhalation challenge in patients with suspected asthma.
Topics: Adenosine Monophosphate; Adult; Asthma; Bronchial Provocation Tests; Cross-Over Studies; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Prospective Studies; Single-Blind Method; Skin Tests; Vital Capacity | 2009 |
Asthma tests in the assessment of military conscripts.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Humans; Male; Mannitol; Methacholine Chloride; Military Personnel; Nitric Oxide; Predictive Value of Tests; Sensitivity and Specificity; Skin Tests; Surveys and Questionnaires; Switzerland; Young Adult | 2010 |
Treatment with a peroxisomal proliferator activated receptor gamma agonist has a modest effect in the allergen challenge model in asthma: a randomised controlled trial.
Topics: Adiponectin; Adolescent; Adult; Allergens; Anti-Inflammatory Agents; Asthma; Biomarkers; Breath Tests; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; PPAR gamma; Rosiglitazone; Thiazolidinediones; Young Adult | 2010 |
Prolonged bronchoprotection against inhaled methacholine by inhaled BI 1744, a long-acting beta(2)-agonist, in patients with mild asthma.
Topics: Administration, Inhalation; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Adult; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Methacholine Chloride | 2009 |
Vitamin D levels, lung function, and steroid response in adult asthma.
Topics: Administration, Inhalation; Adult; Asthma; Body Mass Index; Bronchial Hyperreactivity; Bronchodilator Agents; Cell Growth Processes; Cross-Sectional Studies; Dexamethasone; Drug Interactions; Dual Specificity Phosphatase 1; Female; Forced Expiratory Volume; Glucocorticoids; Humans; Interleukin-10; Lung; Male; Methacholine Chloride; Tumor Necrosis Factor-alpha; Vitamin D; Vitamin D Deficiency | 2010 |
Add-on montelukast to inhaled corticosteroids protects against excessive airway narrowing.
Topics: Acetates; Administration, Inhalation; Adrenal Cortex Hormones; Adult; Asthma; Bronchial Hyperreactivity; Cyclopropanes; Double-Blind Method; Female; Humans; Leukotriene Antagonists; Male; Methacholine Chloride; Middle Aged; Quinolines; Sulfides; Treatment Outcome; Young Adult | 2010 |
Relationships of methacholine and adenosine monophosphate responsiveness with serum vascular endothelial growth factor in children with asthma.
Topics: Adenosine Monophosphate; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cell Count; Cell Membrane Permeability; Child; Eosinophil Cationic Protein; Eosinophils; Female; Humans; Male; Methacholine Chloride; Respiratory Function Tests; Vascular Endothelial Growth Factor A | 2010 |
The effect of challenge method on methacholine-induced changes in sensitivity and air trapping.
Topics: Adult; Asthma; Bronchoconstrictor Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Respiratory Function Tests; Vital Capacity | 2011 |
Bronchial hyperresponsiveness to methacholine/AMP and the bronchodilator response in asthmatic children.
Topics: Adenosine Monophosphate; Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Respiratory Function Tests | 2011 |
Efficacy and safety of etanercept in moderate-to-severe asthma: a randomised, controlled trial.
Topics: Adolescent; Adult; Aged; Anti-Asthmatic Agents; Asthma; Disease Progression; Etanercept; Female; Forced Expiratory Volume; Humans; Immunoglobulin G; Male; Methacholine Chloride; Middle Aged; Quality of Life; Receptors, Tumor Necrosis Factor; Severity of Illness Index; Surveys and Questionnaires; Young Adult | 2011 |
Basophil allergen threshold sensitivity, CD-sens, is a measure of allergen sensitivity in asthma.
Topics: Adult; Allergens; Asthma; Basophils; Female; Humans; Immunologic Tests; Inhalation Exposure; Male; Methacholine Chloride; Middle Aged; Sensitivity and Specificity; Young Adult | 2011 |
Effect of bronchoconstriction on airway remodeling in asthma.
Topics: Adult; Albuterol; Animals; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoconstriction; Bronchodilator Agents; Bronchoscopy; Eosinophils; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Pyroglyphidae; Spirometry; Young Adult | 2011 |
Allergen inhalation challenge in smoking compared with non-smoking asthmatic subjects.
Topics: Administration, Inhalation; Adolescent; Adult; Allergens; Asthma; Cotinine; Humans; Methacholine Chloride; Middle Aged; Smoking; Sputum; Young Adult | 2011 |
Fluticasone/Salmeterol combination confers benefits in people with asthma who smoke.
Topics: Adult; Albuterol; Androstadienes; Asthma; Cross-Over Studies; Double-Blind Method; Drug Combinations; Female; Fluticasone-Salmeterol Drug Combination; Glucocorticoids; Humans; Male; Mannitol; Methacholine Chloride; Placebos; Smoking; Spirometry; Statistics, Nonparametric; Surveys and Questionnaires; Treatment Outcome | 2012 |
The effect of caffeinated coffee on airway response to methacholine and exhaled nitric oxide.
Topics: Adult; Asthma; Bronchial Provocation Tests; Caffeine; Coffee; Exhalation; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Nitric Oxide | 2011 |
Bronchodilator effect of Ipraterol on methacholine-induced bronchoconstriction in asthmatic patients.
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Child; Cross-Over Studies; Double-Blind Method; Drug Combinations; Female; Fenoterol; Forced Expiratory Volume; Humans; Ipratropium; Male; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers; Respiratory Function Tests; Spirometry; Treatment Outcome; Young Adult | 2011 |
RUNX transcription factors: association with pediatric asthma and modulated by maternal smoking.
Topics: Animals; Asthma; Child; Core Binding Factor Alpha 2 Subunit; Female; Fetus; Gene Expression; Genetic Testing; Humans; Male; Methacholine Chloride; Mice; Polymorphism, Single Nucleotide; Pregnancy; Prenatal Exposure Delayed Effects; Real-Time Polymerase Chain Reaction; Risk Factors; Smoking; Tobacco Smoke Pollution | 2011 |
Methacholine challenge as a clinical bioassay of pulmonary delivery of a long-acting β₂-adrenergic agonist.
Topics: Adrenergic beta-2 Receptor Agonists; Adult; Asthma; Bronchoconstrictor Agents; Bronchodilator Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Ethanolamines; Female; Forced Expiratory Volume; Formoterol Fumarate; Hospitals, University; Humans; Male; Methacholine Chloride; Middle Aged; Severity of Illness Index; Therapeutic Equivalency; Young Adult | 2011 |
Airway remodeling and inflammation in competitive swimmers training in indoor chlorinated swimming pools.
Topics: Airway Remodeling; Allergens; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cell Count; Chlorine; Eosinophils; Female; Humans; Inflammation; Male; Mast Cells; Methacholine Chloride; Mucins; Neutrophils; Nitric Oxide; Skin Tests; Spirometry; Swimming; Swimming Pools; T-Lymphocytes; Young Adult | 2012 |
Is methacholine challenge sufficient to rule out bronchial hyperresponsiveness in patients with suspected asthma?
Topics: Adenosine; Administration, Inhalation; Adolescent; Adult; Aged; Asthma; Breath Tests; Bronchial Hyperreactivity; Bronchial Provocation Tests; Diagnosis, Differential; Female; Humans; Male; Methacholine Chloride; Middle Aged; Predictive Value of Tests; Prognosis; Sensitivity and Specificity | 2012 |
Peripheral blood gene expression changes during allergen inhalation challenge in atopic asthmatic individuals.
Topics: Adult; Allergens; Asthma; Blood; Bronchial Provocation Tests; Cell Movement; Down-Regulation; Eukaryotic Initiation Factor-2; Female; Forced Expiratory Volume; Gene Expression Profiling; Globins; Hemoglobins; Humans; Inflammation; Interferons; Male; Methacholine Chloride; Middle Aged; Oligonucleotide Array Sequence Analysis; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; RNA; Signal Transduction; Up-Regulation; Young Adult | 2012 |
Effect of bariatric surgery on airway response and lung function in obese subjects with asthma.
Topics: Adult; Anti-Asthmatic Agents; Asthma; Bariatric Surgery; Body Mass Index; Bronchial Provocation Tests; Bronchoconstrictor Agents; C-Reactive Protein; Female; Humans; Inflammation; Male; Methacholine Chloride; Middle Aged; Obesity, Morbid; Prospective Studies; Respiratory Mechanics; Weight Loss; Young Adult | 2012 |
Efficacy and safety of sublingual immunotherapy with grass monomeric allergoid: comparison between two different treatment regimens.
Topics: Administration, Sublingual; Adult; Aged; Allergoids; Antigens, Plant; Asthma; Carbamates; Clinical Protocols; Conjunctivitis, Allergic; Desensitization, Immunologic; Female; Humans; Italy; Male; Methacholine Chloride; Middle Aged; Plant Extracts; Poaceae; Prospective Studies; Rhinitis, Allergic, Seasonal; Seasons; Treatment Outcome | 2011 |
Methacholine challenge test: diagnostic characteristics in asthmatic patients receiving controller medications.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Cohort Studies; Cross-Sectional Studies; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Predictive Value of Tests; Respiratory Function Tests; Sensitivity and Specificity; Treatment Outcome; Young Adult | 2012 |
The use of the peroxisome proliferator-activated receptors γ agonist rosiglitazone to treat airway hyperreactivity.
Topics: Adult; Animals; Asthma; Breath Tests; Bronchial Hyperreactivity; Cohort Studies; Confidence Intervals; Dose-Response Relationship, Drug; Feasibility Studies; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Mice; Middle Aged; Nitric Oxide; PPAR gamma; Rosiglitazone; Thiazolidinediones | 2012 |
Usefulness of impulse oscillometry and fractional exhaled nitric oxide in children with Eosinophilic bronchitis.
Topics: Asthma; Biomarkers; Bronchial Provocation Tests; Bronchitis; Bronchoconstrictor Agents; Bronchodilator Agents; Case-Control Studies; Child; Diagnosis, Differential; Eosinophils; Exhalation; Female; Humans; Leukocyte Count; Male; Methacholine Chloride; Nitric Oxide; Oscillometry; Pulmonary Eosinophilia; ROC Curve; Sensitivity and Specificity; Spirometry; Sputum | 2013 |
Use of continuous positive airway pressure reduces airway reactivity in adults with asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Continuous Positive Airway Pressure; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Nitric Oxide; Respiratory Function Tests; Spirometry; Stress, Mechanical; Time Factors; Treatment Outcome | 2013 |
Relief of methacholine-induced bronchospasm with extrafine beclomethasone dipropionate/formoterol in comparison with salbutamol in asthma.
Topics: Adult; Albuterol; Asthma; Beclomethasone; Bronchial Spasm; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Ethanolamines; Female; Forced Expiratory Volume; Formoterol Fumarate; Humans; Male; Methacholine Chloride; Middle Aged | 2012 |
Transient sputum eosinophilia may occur over time in non-eosinophilic asthma and this is not prevented by salmeterol.
Topics: Adult; Albuterol; Androstadienes; Asthma; Bronchodilator Agents; Eosinophilia; Female; Fluticasone; Humans; Male; Methacholine Chloride; Middle Aged; Neutrophils; Salmeterol Xinafoate; Sputum; Young Adult | 2012 |
Association of airway pentosidine levels with bronchodilator response mediated by salbutamol administration in asthmatic patients.
Topics: Adult; Airway Obstruction; Albuterol; Arginine; Asthma; Biomarkers; Bronchial Provocation Tests; Bronchodilator Agents; Case-Control Studies; Cross-Sectional Studies; Eosinophils; Female; Humans; Lysine; Male; Methacholine Chloride; Nitric Oxide; Sputum; Young Adult | 2012 |
Leukotriene D4 and methacholine bronchial provocation tests for identifying leukotriene-responsiveness subtypes.
Topics: Administration, Inhalation; Adult; Asthma; Bronchi; Bronchial Provocation Tests; Case-Control Studies; Cross-Over Studies; Humans; Leukotriene D4; Methacholine Chloride | 2013 |
Axial distribution of nitric oxide airway production in asthma patients.
Topics: Adenosine Monophosphate; Adrenal Cortex Hormones; Adult; Asthma; Breath Tests; Bronchi; Bronchoconstriction; Cross-Over Studies; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Muscarinic Agonists; Nitric Oxide; Pulmonary Ventilation; Single-Blind Method; Vital Capacity | 2013 |
Salbutamol tolerance to bronchoprotection: course of onset.
Topics: Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Drug Tolerance; Female; Forced Expiratory Volume; Humans; Ipratropium; Male; Methacholine Chloride; Middle Aged; Young Adult | 2012 |
Airway hyperresponsiveness and quality of life in Western red cedar asthmatics removed from exposure.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Demography; Environmental Exposure; Humans; Male; Methacholine Chloride; Middle Aged; Quality of Life; Spirometry; Surveys and Questionnaires; Thuja | 2012 |
Nebulized lidocaine blunts airway hyper-responsiveness in experimental feline asthma.
Topics: Airway Resistance; Allergens; Anesthetics, Local; Animals; Asthma; Bronchoconstrictor Agents; Cat Diseases; Cats; Cross-Over Studies; Cynodon; Eosinophilia; Female; Lidocaine; Male; Methacholine Chloride; Nebulizers and Vaporizers | 2013 |
Effect of inhaled fluticasone on bronchial responsiveness to neurokinin A in asthma.
Topics: Administration, Inhalation; Adolescent; Adult; Androstadienes; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Female; Fluticasone; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Neurokinin A | 2002 |
Inhaled sodium fluoride decreases airway responsiveness to acetylcholine analogs in vivo.
Topics: Acetylcholine; Administration, Inhalation; Adult; Airway Resistance; Animals; Asthma; Blood Pressure; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Calcium Channel Blockers; Carbachol; Female; Heart Rate; Humans; Male; Methacholine Chloride; Muscle, Smooth; Rats; Rats, Wistar; Sodium Fluoride; Verapamil | 2002 |
Benefits of immunotherapy with a standardized Dermatophagoides pteronyssinus extract in asthmatic children: a three-year prospective study.
Topics: Adolescent; Antigens, Dermatophagoides; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Desensitization, Immunologic; Female; Humans; Male; Methacholine Chloride; Prospective Studies; Respiratory Mechanics; Skin Tests | 2002 |
Airways hyper-responsiveness to bradykinin and methacholine: effects of inhaled fluticasone.
Topics: Administration, Inhalation; Adolescent; Adult; Analysis of Variance; Androstadienes; Asthma; Bradykinin; Bronchial Provocation Tests; Bronchoconstrictor Agents; Depression, Chemical; Double-Blind Method; Female; Fluticasone; Forced Expiratory Volume; Glucocorticoids; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Vasodilator Agents | 2002 |
Reduction in exhaled nitric oxide immediately after methacholine challenge in asthmatic children.
Topics: Adolescent; Asthma; Breath Tests; Bronchial Provocation Tests; Bronchodilator Agents; Child; Forced Expiratory Volume; Humans; Methacholine Chloride; Nitric Oxide | 2002 |
Effects of inhaled tumour necrosis factor alpha in subjects with mild asthma.
Topics: Adult; Asthma; Bronchodilator Agents; Carbon Monoxide; Cell Count; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Nitric Oxide; RNA, Messenger; Sputum; Tumor Necrosis Factor-alpha | 2002 |
Actions other than smooth muscle relaxation may play a role in the protective effects of formoterol on the allergen-induced late asthmatic reaction.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Allergens; Asthma; Bronchi; Bronchoconstrictor Agents; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Ethanolamines; Female; Forced Expiratory Volume; Formoterol Fumarate; Humans; Male; Methacholine Chloride; Muscle Relaxation; Muscle, Smooth; Time Factors | 2002 |
Airway and systemic effects of hydrofluoroalkane fluticasone and beclomethasone in patients with asthma.
Topics: Adult; Androstadienes; Anti-Asthmatic Agents; Asthma; Beclomethasone; Bronchoconstrictor Agents; Bronchodilator Agents; Creatinine; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Fluticasone; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Hydrocarbons, Fluorinated; Hydrocortisone; Male; Methacholine Chloride | 2002 |
Ozone exposure increases eosinophilic airway response induced by previous allergen challenge.
Topics: Adolescent; Adult; Allergens; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Eosinophils; Forced Expiratory Volume; Humans; Interleukin-8; Leukocyte Count; Methacholine Chloride; Oxidants, Photochemical; Ozone; Respiratory Mechanics; Single-Blind Method; Sputum; Vital Capacity | 2002 |
Importance of drug delivery system in steroid aerosol therapy via nebulizer.
Topics: Adult; Albuterol; Animals; Anti-Asthmatic Agents; Asthma; Beclomethasone; Bronchoconstrictor Agents; Bronchodilator Agents; Drug Delivery Systems; Female; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Mites; Nebulizers and Vaporizers; Peak Expiratory Flow Rate; Spirometry | 2002 |
A methacholine challenge dose-response study for development of a pharmacodynamic bioequivalence methodology for albuterol metered- dose inhalers.
Topics: Administration, Inhalation; Adolescent; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bayes Theorem; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Metered Dose Inhalers; Methacholine Chloride; Sensitivity and Specificity | 2002 |
Changes in sputum counts and airway hyperresponsiveness after budesonide: monitoring anti-inflammatory response on the basis of surrogate markers of airway inflammation.
Topics: Adenosine Monophosphate; Adult; Asthma; Bronchial Hyperreactivity; Budesonide; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Sputum | 2002 |
Vascular component of airway remodeling in asthma is reduced by high dose of fluticasone.
Topics: Administration, Inhalation; Administration, Topical; Adolescent; Adult; Androstadienes; Anti-Inflammatory Agents; Asthma; Basement Membrane; Biopsy; Bronchi; Bronchoconstrictor Agents; Bronchodilator Agents; Double-Blind Method; Female; Fluticasone; Glucocorticoids; Humans; Inflammation; Male; Methacholine Chloride; Time Factors | 2003 |
Effect of candesartan, a type 1 angiotensin II receptor antagonist, on bronchial hyper-responsiveness to methacholine in patients with bronchial asthma.
Topics: Administration, Inhalation; Adult; Aged; Angiotensin II; Angiotensin Receptor Antagonists; Asthma; Benzimidazoles; Biphenyl Compounds; Bronchi; Bronchoconstrictor Agents; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Tetrazoles | 2002 |
Liposome-entrapped D. pteronyssinus vaccination in mild asthma patients: effect of 1-year double-blind, placebo-controlled trial on inflammation, bronchial hyperresponsiveness and immediate and late bronchial responses to the allergen.
Topics: Adult; Antigens, Dermatophagoides; Arthropod Proteins; Asthma; Blood Proteins; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cysteine Endopeptidases; Dermatophagoides pteronyssinus; Dose-Response Relationship, Drug; Double-Blind Method; Eosinophil Granule Proteins; Eosinophils; Female; Humans; Immunologic Tests; Immunotherapy; Intercellular Adhesion Molecule-1; Leukocyte Count; Liposomes; Male; Methacholine Chloride; Ribonucleases; Sputum; Statistics, Nonparametric | 2002 |
Fifty microg b.i.d. of inhaled fluticasone propionate (FP) are effective in stable asthmatics previously treated with a higher dose of FP.
Topics: Adult; Androstadienes; Asthma; Bronchoconstrictor Agents; Bronchodilator Agents; Dose-Response Relationship, Drug; Double-Blind Method; Eosinophils; Female; Fluticasone; Forced Expiratory Volume; Glucocorticoids; Humans; Male; Methacholine Chloride; Middle Aged; Recurrence; Sputum | 2003 |
A comparison of salmeterol and formoterol in attenuating airway responses to short-acting beta2-agonists.
Topics: Adrenergic beta-Agonists; Adult; Aged; Albuterol; Asthma; Bronchoconstrictor Agents; Bronchodilator Agents; Dose-Response Relationship, Drug; Double-Blind Method; Ethanolamines; Female; Formoterol Fumarate; Humans; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests; Salmeterol Xinafoate | 2003 |
Relations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthma.
Topics: Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Blood Proteins; Bronchoconstrictor Agents; Budesonide; Child; Child, Preschool; Cohort Studies; Eosinophil Granule Proteins; Eosinophils; Female; Forced Expiratory Volume; Humans; Hypersensitivity; Immunoglobulin E; Leukocyte Count; Male; Methacholine Chloride; Nedocromil; Nitric Oxide; Respiration; Respiratory Function Tests; Ribonucleases; Severity of Illness Index; Skin Tests; Spirometry; Statistics, Nonparametric | 2003 |
Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine.
Topics: Adult; Aged; Asthma; Bronchitis, Chronic; Bronchoconstriction; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Interleukin-17; Male; Methacholine Chloride; Middle Aged; Pulmonary Disease, Chronic Obstructive; Sputum; Vital Capacity | 2003 |
Effects of fluticasone vs. fluticasone/salmeterol on airway calibre and airway hyperresponsiveness in mild persistent asthma.
Topics: Adult; Albuterol; Androstadienes; Asthma; Bronchi; Bronchoconstrictor Agents; Bronchodilator Agents; Creatinine; Cross-Over Studies; Double-Blind Method; Female; Fluticasone; Forced Expiratory Volume; Humans; Hydrocortisone; Male; Methacholine Chloride; Nitric Oxide; Peak Expiratory Flow Rate; Salmeterol Xinafoate | 2003 |
Electrostatic charge on spacer devices and salbutamol response in young children.
Topics: Administration, Inhalation; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Child; Child, Preschool; Female; Humans; Hydrocarbons, Fluorinated; Inhalation Spacers; Male; Methacholine Chloride; Static Electricity | 2003 |
Association of body mass with pulmonary function in the Childhood Asthma Management Program (CAMP).
Topics: Age Distribution; Asthma; Body Mass Index; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Child; Child, Preschool; Cohort Studies; Cross-Sectional Studies; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Multivariate Analysis; Obesity; Regression Analysis; Vital Capacity | 2003 |
The effect of montelukast on bronchial provocation tests and exhaled nitric oxide levels in asthmatic patients.
Topics: Acetates; Adenosine; Administration, Oral; Adolescent; Adult; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Cyclopropanes; Exercise; Female; Humans; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Quinolines; Spirometry; Sulfides; Treatment Outcome; Vasodilator Agents | 2003 |
Deep breath reversal and exponential return of methacholine-induced obstruction in asthmatic and nonasthmatic subjects.
Topics: Adult; Airway Obstruction; Airway Resistance; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Respiratory Mechanics | 2004 |
Overall contribution of chest wall hyperinflation to breathlessness in asthma.
Topics: Adult; Asthma; Bronchoconstrictor Agents; Dyspnea; Functional Residual Capacity; Humans; Male; Methacholine Chloride; Middle Aged; Regression Analysis; Thoracic Wall | 2003 |
A probative approach for noninvasive evaluation of airway hyperresponsiveness and remodeling in adult asthmatics.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Airway Resistance; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Disease Models, Animal; Female; Humans; Male; Methacholine Chloride; Middle Aged; Models, Biological; Muscle, Smooth; Outcome and Process Assessment, Health Care; Practice Guidelines as Topic; Respiratory Function Tests; Treatment Outcome | 2004 |
Methacholine challenge testing: comparison of the two American Thoracic Society-recommended methods.
Topics: Administration, Inhalation; Adolescent; Adult; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Over Studies; Female; Humans; Male; Methacholine Chloride; Middle Aged; Probability; Prognosis; Pulmonary Gas Exchange; Respiratory Function Tests; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Societies, Medical | 2004 |
Increased responses to inhaled oxitropium bromide in asthmatic patients with active hepatitis C virus infection.
Topics: Administration, Inhalation; Asthma; Bronchial Hyperreactivity; Cross-Sectional Studies; Forced Expiratory Volume; Hepatitis C, Chronic; Humans; Interferons; Methacholine Chloride; Middle Aged; Parasympatholytics; Scopolamine Derivatives | 2004 |
Budesonide/formoterol in a single inhaler rapidly relieves methacholine-induced moderate-to-severe bronchoconstriction.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Albuterol; Androstadienes; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Budesonide; Budesonide, Formoterol Fumarate Drug Combination; Cross-Over Studies; Double-Blind Method; Drug Combinations; Ethanolamines; Female; Fluticasone-Salmeterol Drug Combination; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers | 2004 |
Clarithromycin reduces the severity of bronchial hyperresponsiveness in patients with asthma.
Topics: Adult; Anti-Bacterial Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Clarithromycin; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Spirometry; Time Factors; Treatment Outcome | 2004 |
Effect of viewing a humorous vs. nonhumorous film on bronchial responsiveness in patients with bronchial asthma.
Topics: Adult; Affect; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Catechin; Female; Humans; Laughter Therapy; Male; Methacholine Chloride; Reference Values; Respiratory Function Tests; Wit and Humor as Topic | 2004 |
Unevenness of ventilation assessed by the expired CO(2) gas volume versus V(T) curve in asthmatic patients.
Topics: Administration, Inhalation; Adult; Algorithms; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Carbon Dioxide; Exhalation; Female; Humans; Lung Volume Measurements; Male; Methacholine Chloride; Middle Aged; Pulmonary Ventilation; Respiratory Dead Space; Tidal Volume | 2004 |
Effects of hydrofluoroalkane formulations of ciclesonide 400 microg once daily vs fluticasone 250 microg twice daily on methacholine hyper-responsiveness in mild-to-moderate persistent asthma.
Topics: Administration, Inhalation; Androstadienes; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Female; Fluticasone; Forced Expiratory Volume; Humans; Hydrocarbons, Fluorinated; Male; Methacholine Chloride; Middle Aged; Pregnenediones; Vital Capacity | 2004 |
Effect of inspiratory flow on methacholine challenge in children.
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Female; Humans; Inhalation; Male; Methacholine Chloride; Pulmonary Ventilation; Reproducibility of Results; Spirometry | 2004 |
An effective strategy for diagnosing occupational asthma: use of induced sputum.
Topics: Adult; Asthma; Bronchial Provocation Tests; Cross-Over Studies; Eosinophils; Female; Humans; Leukocyte Count; Male; Methacholine Chloride; Occupational Diseases; Peak Expiratory Flow Rate; Prospective Studies; Sensitivity and Specificity; Sputum; Workplace | 2004 |
Relief of dyspnoea by beta2-agonists after methacholine-induced bronchoconstriction.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchoconstriction; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Dyspnea; Ethanolamines; Female; Forced Expiratory Volume; Formoterol Fumarate; Humans; Male; Methacholine Chloride; Nebulizers and Vaporizers; Salmeterol Xinafoate; Time Factors | 2004 |
Improved bronchodilator effect of deep inhalation after allergen avoidance in asthmatic children.
Topics: Administration, Inhalation; Adolescent; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Child; Dust; Eosinophils; Female; Humans; Male; Methacholine Chloride; Mites; Sputum; Treatment Outcome | 2004 |
Dosimeter methacholine challenge: comparison of maximal versus submaximal inhalations.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; False Negative Reactions; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers; Spirometry | 2004 |
Effectiveness of montelukast in the treatment of cough variant asthma.
Topics: Acetates; Adrenergic beta-Agonists; Adult; Aged; Anti-Asthmatic Agents; Antitussive Agents; Asthma; Bronchial Provocation Tests; Cough; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; Female; Forced Expiratory Volume; Humans; Leukotriene Antagonists; Male; Methacholine Chloride; Middle Aged; Monitoring, Ambulatory; Pilot Projects; Quinolines; Severity of Illness Index; Sulfides; Treatment Outcome | 2004 |
Morphometric changes after thermal and methacholine bronchoprovocations.
Topics: Adult; Anatomy, Cross-Sectional; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoconstriction; Bronchography; Female; Humans; Male; Methacholine Chloride; Middle Aged; Radiographic Image Interpretation, Computer-Assisted; Temperature | 2005 |
Differential effects of fluticasone and montelukast on allergen-induced asthma.
Topics: Acetates; Adult; Allergens; Androstadienes; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Cross-Over Studies; Cyclopropanes; Double-Blind Method; Eosinophils; Female; Fluticasone; Forced Expiratory Volume; Humans; Leukotriene Antagonists; Male; Methacholine Chloride; Quinolines; Sputum; Sulfides; Time Factors | 2005 |
Salbutamol pMDI gives less protection to methacholine induced airway obstruction than salbutamol via spacer or DPI.
Topics: Administration, Inhalation; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Female; Humans; Male; Metered Dose Inhalers; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers | 2005 |
Effect of budesonide and montelukast in asthmatic children exposed to relevant allergens.
Topics: Acetates; Allergens; Anti-Asthmatic Agents; Antigens, Dermatophagoides; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bronchodilator Agents; Budesonide; Child; Cyclopropanes; Eosinophils; Exhalation; Female; Humans; Lung; Male; Methacholine Chloride; Nitric Oxide; Quinolines; Respiratory Function Tests; Sputum; Sulfides | 2005 |
Comparison of sputum induction using inhaled methacholine or hypertonic saline.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cell Count; Coloring Agents; Eosinophils; Epithelial Cells; Female; Humans; Leukocyte Count; Lymphocyte Count; Lymphocytes; Macrophages; Male; Methacholine Chloride; Middle Aged; Neutrophils; Saline Solution, Hypertonic; Sputum | 2005 |
Relationship between airway responsiveness to neurokinin A and methacholine in asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Humans; Male; Methacholine Chloride; Middle Aged; Neurokinin A; Respiratory Function Tests | 2005 |
Formoterol used as needed in patients with intermittent or mild persistent asthma.
Topics: Administration, Inhalation; Adolescent; Adrenergic beta-Agonists; Adult; Aged; Aged, 80 and over; Asthma; Bronchodilator Agents; Child; Dose-Response Relationship, Drug; Double-Blind Method; Ethanolamines; Female; Formoterol Fumarate; Humans; Male; Methacholine Chloride; Middle Aged; Terbutaline; Treatment Outcome | 2005 |
Airway and systemic effects of hydrofluoroalkane formulations of high-dose ciclesonide and fluticasone in moderate persistent asthma.
Topics: Administration, Inhalation; Androstadienes; Asthma; Breath Tests; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Corticotropin-Releasing Hormone; Cross-Over Studies; Double-Blind Method; Female; Fluticasone; Humans; Hydrocortisone; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Peak Expiratory Flow Rate; Pregnenediones; Quality of Life; Spirometry | 2005 |
The effect of marimastat, a metalloprotease inhibitor, on allergen-induced asthmatic hyper-reactivity.
Topics: Adult; Antigens, Dermatophagoides; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Cross-Over Studies; Double-Blind Method; Female; Humans; Hydroxamic Acids; Male; Metalloproteases; Methacholine Chloride; Middle Aged; Pilot Projects; Tumor Necrosis Factor-alpha | 2005 |
Bronchoprotective and bronchodilator effects of an HFA pMDI vs. a CFC pMDI and a DPI containing formoterol in asthma patients.
Topics: Adult; Aerosol Propellants; Asthma; Blood Glucose; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Chlorofluorocarbons; Double-Blind Method; Drug Administration Schedule; Ethanolamines; Female; Forced Expiratory Volume; Formoterol Fumarate; Humans; Hydrocarbons, Fluorinated; Male; Metered Dose Inhalers; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers; Potassium; Powders | 2005 |
Effects of HFA- and CFC-beclomethasone dipropionate on the bronchial response to methacholine (MCh) in mild asthma.
Topics: Administration, Inhalation; Adult; Aerosol Propellants; Aged; Anti-Asthmatic Agents; Asthma; Beclomethasone; Bronchi; Bronchoconstrictor Agents; Chlorofluorocarbons; Cross-Over Studies; Double-Blind Method; Female; Humans; Hydrocarbons, Fluorinated; Male; Metered Dose Inhalers; Methacholine Chloride; Middle Aged; Respiratory Function Tests | 2005 |
Inhaled corticosteroids and the beneficial effect of deep inspiration in asthma.
Topics: Administration, Inhalation; Adult; Aged; Androstadienes; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Female; Fluticasone; Forced Expiratory Volume; Humans; Inhalation; Male; Methacholine Chloride; Middle Aged; Respiratory Mechanics; Respiratory Therapy; Severity of Illness Index; Vital Capacity | 2005 |
Methacholine bronchial provocation measured by spirometry versus wheeze detection in preschool children.
Topics: Asthma; Auscultation; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Child, Preschool; Dose-Response Relationship, Drug; Feasibility Studies; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Respiratory Sounds; Spirometry | 2005 |
Effect of a very late antigen-4 receptor antagonist on allergen-induced airway responses and inflammation in asthma.
Topics: Administration, Inhalation; Adolescent; Adult; Allergens; Asthma; Bronchi; Bronchial Provocation Tests; Bronchospirometry; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Imidazoles; Integrin alpha4beta1; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Propionates; Receptors, Very Late Antigen; Sputum | 2005 |
Bimosiamose, an inhaled small-molecule pan-selectin antagonist, attenuates late asthmatic reactions following allergen challenge in mild asthmatics: a randomized, double-blind, placebo-controlled clinical cross-over-trial.
Topics: Administration, Inhalation; Adult; Allergens; Anti-Asthmatic Agents; Asthma; Breath Tests; Bronchial Provocation Tests; Cross-Over Studies; Double-Blind Method; Forced Expiratory Volume; Hexanes; Humans; Leukocyte Count; Lymphocyte Count; Male; Mannose; Methacholine Chloride; Nitric Oxide; Treatment Outcome | 2006 |
The effect of reducing the fine-particle mass of salmeterol from metered-dose inhalers on bronchodilatation and bronchoprotection against methacholine challenge: a randomized, placebo-controlled, double-blind, crossover study.
Topics: Adult; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Metered Dose Inhalers; Methacholine Chloride; Middle Aged; Particle Size; Salmeterol Xinafoate | 2005 |
The effect of ipratropium nasal spray on bronchial methacholine challenge.
Topics: Adult; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Female; Humans; Ipratropium; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests | 2005 |
Lack of tachyphylaxis to methacholine at 24 h.
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Clinical Trials as Topic; Female; Humans; Male; Methacholine Chloride; Middle Aged; Retrospective Studies; Tachyphylaxis; Time Factors | 2005 |
Tolerance to bronchodilation during treatment with long-acting beta-agonists, a randomised controlled trial.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchodilator Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Ethanolamines; Female; Formoterol Fumarate; Humans; Male; Methacholine Chloride; Middle Aged; Treatment Outcome | 2005 |
Formoterol induces tolerance to the bronchodilating effect of Salbutamol following methacholine-provocation test in asthmatic children.
Topics: Adolescent; Albuterol; Asthma; Blood Cell Count; Bronchial Provocation Tests; Bronchodilator Agents; Child; Double-Blind Method; Drug Interactions; Drug Tolerance; Eosinophils; Ethanolamines; Female; Forced Expiratory Volume; Formoterol Fumarate; Humans; Male; Maximal Expiratory Flow Rate; Methacholine Chloride; Prospective Studies | 2006 |
Formoterol attenuates neutrophilic airway inflammation in asthma.
Topics: Adult; Asthma; Bronchodilator Agents; Double-Blind Method; Ethanolamines; Female; Forced Expiratory Volume; Formoterol Fumarate; Humans; Inflammation; Male; Methacholine Chloride; Middle Aged; Neutrophils; Nitric Oxide; Respiratory Function Tests; Vital Capacity | 2005 |
Glycopyrrolate causes prolonged bronchoprotection and bronchodilatation in patients with asthma.
Topics: Asthma; Bronchial Spasm; Bronchoconstrictor Agents; Cholinergic Agents; Cross-Over Studies; Double-Blind Method; Glycopyrrolate; Humans; Methacholine Chloride; Placebos | 2005 |
Assessment of different methods of inhalation from salbutamol metered dose inhalers by urinary drug excretion and methacholine challenge.
Topics: Administration, Inhalation; Adult; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Drug Administration Schedule; Forced Expiratory Volume; Humans; Metered Dose Inhalers; Methacholine Chloride | 2005 |
Bronchial responsiveness to methacholine and adenosine 5'-monophosphate (AMP) in young children with post-infectious bronchiolitis obliterans.
Topics: Adenosine Monophosphate; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchiolitis Obliterans; Case-Control Studies; Child; Child, Preschool; Female; Humans; Male; Methacholine Chloride; Oximetry; Respiratory Sounds | 2006 |
Effect of omalizumab on adenosine 5'-monophosphate responsiveness in subjects with allergic asthma.
Topics: Adenosine Monophosphate; Adolescent; Adult; Aged; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Female; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Omalizumab; Respiratory Hypersensitivity | 2006 |
Bronchial plasma exudation after adenosine monophosphate or methacholine challenge.
Topics: Adenosine Monophosphate; Adult; Asthma; Blood Proteins; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Exudates and Transudates; Female; Humans; Lung; Male; Methacholine Chloride; Sputum | 2005 |
Limited beta2-adrenoceptor haplotypes display different agonist mediated airway responses in asthmatics.
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Asthma; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fenoterol; Genetic Predisposition to Disease; Haplotypes; Humans; Lung; Male; Methacholine Chloride; Placebo Effect; Polymorphism, Single Nucleotide; Receptors, Adrenergic, beta-2 | 2006 |
Montelukast improves regional air-trapping due to small airways obstruction in asthma.
Topics: Acetates; Adolescent; Adult; Aged; Anti-Asthmatic Agents; Asthma; Cross-Over Studies; Cyclopropanes; Double-Blind Method; Female; Humans; Linear Models; Male; Methacholine Chloride; Middle Aged; Quinolines; Respiratory Function Tests; Statistics, Nonparametric; Sulfides; Tomography, X-Ray Computed; Treatment Outcome | 2006 |
Comparison of asthma treatment given in addition to inhaled corticosteroids on airway inflammation and responsiveness.
Topics: Acetates; Administration, Inhalation; Adult; Aged; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Budesonide; Cross-Over Studies; Cyclopropanes; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Eosinophils; Ethanolamines; Formoterol Fumarate; Glucocorticoids; Humans; Leukocyte Count; Lung Volume Measurements; Male; Methacholine Chloride; Middle Aged; Quinolines; Sputum; Sulfides | 2006 |
The structural basis of airways hyperresponsiveness in asthma.
Topics: Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Muscle, Smooth; Residual Volume; Respiratory Muscles; Tomography, X-Ray Computed; Total Lung Capacity; Vital Capacity | 2006 |
Evidence of a role of tumor necrosis factor alpha in refractory asthma.
Topics: ADAM Proteins; ADAM17 Protein; Adolescent; Adult; Aged; Asthma; Biomarkers; Bronchial Hyperreactivity; Case-Control Studies; Cross-Over Studies; Double-Blind Method; Etanercept; Female; Forced Expiratory Volume; Humans; Immunoglobulin G; Immunologic Factors; Male; Methacholine Chloride; Middle Aged; Monocytes; Pilot Projects; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Treatment Outcome; Tumor Necrosis Factor-alpha; Up-Regulation | 2006 |
A comparison of 2 extrafine hydrofluoroalkane-134a-beclomethasone formulations on methacholine hyperresponsiveness.
Topics: Adolescent; Adult; Aerosol Propellants; Aged; Anti-Asthmatic Agents; Asthma; Beclomethasone; Bronchi; Bronchial Provocation Tests; Bronchoconstrictor Agents; Creatine; Female; Humans; Hydrocarbons, Fluorinated; Hydrocortisone; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Spirometry; Therapeutic Equivalency; Treatment Outcome | 2006 |
Deep inhalation bronchoprotection in asthma: correlation with airway responsiveness.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Airway Resistance; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Female; Humans; Inhalation; Male; Methacholine Chloride; Total Lung Capacity | 2006 |
Symptom perception in childhood asthma: the role of anxiety and asthma severity.
Topics: Adolescent; Anxiety; Asthma; Bronchoconstrictor Agents; Child; Female; Humans; Male; Methacholine Chloride; Missouri; Severity of Illness Index; Surveys and Questionnaires | 2006 |
Low-dose endotoxin in allergic asthmatics: effect on bronchial and inflammatory response to cat allergen.
Topics: Adult; Allergens; Analysis of Variance; Animals; Asthma; Bronchi; Bronchial Provocation Tests; Cats; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Eosinophil Cationic Protein; Eosinophils; Female; Humans; Lipopolysaccharides; Male; Methacholine Chloride; Middle Aged; Sputum; Time Factors | 2006 |
Bronchial responsiveness to leukotriene D4 is resistant to inhaled fluticasone propionate.
Topics: Administration, Inhalation; Adult; Androstadienes; Asthma; Bronchi; Cross-Over Studies; Double-Blind Method; Female; Fluticasone; Humans; Leukotriene D4; Leukotriene E4; Male; Methacholine Chloride | 2006 |
Ding Chuan Tang, a Chinese herb decoction, could improve airway hyper-responsiveness in stabilized asthmatic children: a randomized, double-blind clinical trial.
Topics: Adolescent; Asthma; Child; Compliance; Double-Blind Method; Drugs, Chinese Herbal; Female; Humans; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Plant Extracts; Spirometry | 2006 |
Characteristics of asthma resistant to moderate dose inhaled corticosteroid treatment on bronchial hyperresponsiveness.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Androstadienes; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Eosinophils; Female; Fluticasone; Forced Expiratory Volume; Humans; Inflammation; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Respiratory Function Tests | 2006 |
Effect of challenge method on sensitivity, reactivity, and maximal response to methacholine.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Sensitivity and Specificity; Tidal Volume | 2006 |
Effects of inhaled ciclesonide on circulating T-helper type 1/T-helper type 2 cells in atopic asthmatics after allergen challenge.
Topics: Administration, Inhalation; Adult; Allergens; Analysis of Variance; Asthma; Biomarkers; Bronchial Provocation Tests; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Eosinophils; Female; Flow Cytometry; Glucocorticoids; Humans; Hypersensitivity; Interferon-gamma; Interleukin-4; Lymphocyte Count; Male; Methacholine Chloride; Pregnenediones; Sputum | 2006 |
The effects of inhaled budesonide and formoterol in combination and alone when given directly after allergen challenge.
Topics: Administration, Inhalation; Adolescent; Adult; Allergens; Asthma; Bronchial Hyperreactivity; Budesonide; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Ethanolamines; Female; Forced Expiratory Volume; Formoterol Fumarate; Humans; Male; Methacholine Chloride | 2007 |
Onset of relief of dyspnoea with budesonide/formoterol or salbutamol following methacholine-induced severe bronchoconstriction in adults with asthma: a double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Budesonide; Double-Blind Method; Drug Combinations; Dyspnea; Ethanolamines; Female; Formoterol Fumarate; Humans; Male; Methacholine Chloride; Middle Aged; Placebo Effect; Treatment Outcome | 2006 |
The variability of regional airflow obstruction within the lungs of patients with asthma: assessment with hyperpolarized helium-3 magnetic resonance imaging.
Topics: Adult; Airway Obstruction; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Helium; Humans; Lung; Magnetic Resonance Imaging; Methacholine Chloride; Middle Aged; Radioisotopes; Radiopharmaceuticals; Spirometry | 2007 |
Omeprazole reduces the response to capsaicin but not to methacholine in asthmatic patients with proximal reflux.
Topics: Adult; Airway Resistance; Analgesics, Non-Narcotic; Anti-Ulcer Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Capsaicin; Esophageal pH Monitoring; Female; Forced Expiratory Volume; Gastroesophageal Reflux; Humans; Hydrogen-Ion Concentration; Male; Methacholine Chloride; Middle Aged; Omeprazole; Treatment Outcome | 2007 |
Comparison of percentage fall in FVC at the provocative concentration of methacholine causing a 20% fall in FEV(1) between patients with asymptomatic bronchial hyperresponsiveness and mild asthma.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Dose-Response Relationship, Drug; Eosinophils; Female; Forced Expiratory Volume; Humans; Immunoglobulin E; Male; Methacholine Chloride; Retrospective Studies; Severity of Illness Index; Vital Capacity | 2007 |
Long-term asthma treatment guided by airway hyperresponsiveness in children: a randomised controlled trial.
Topics: Administration, Inhalation; Adolescent; Albuterol; Androstadienes; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Child; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Fluticasone; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Salmeterol Xinafoate; Treatment Outcome | 2007 |
Comparison of the dose response to levalbuterol with and without pretreatment with S-albuterol after methacholine-induced bronchoconstriction.
Topics: Adolescent; Adult; Albuterol; Area Under Curve; Asthma; Breath Tests; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Cholinergic Antagonists; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Antagonism; Forced Expiratory Volume; Humans; Ipratropium; Methacholine Chloride; Middle Aged; Nitric Oxide; Prospective Studies; Stereoisomerism | 2007 |
Relationship between airway reactivity induced by methacholine or ultrasonically nebulized distilled cold water and BAL fluid cellular constituents in patients with sulfur mustard gas-induced asthma.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Bronchoscopy; Chemical Warfare Agents; Cold Temperature; Cross-Over Studies; Eosinophils; Forced Expiratory Volume; Humans; Leukocyte Count; Methacholine Chloride; Mustard Gas; Nebulizers and Vaporizers; Ultrasonics; Veterans; Water | 2007 |
Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation.
Topics: Adrenal Cortex Hormones; Adult; Airway Resistance; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Female; Forced Expiratory Volume; Humans; London; Lung; Lung Volume Measurements; Male; Methacholine Chloride; Middle Aged; Phenotype; Severity of Illness Index; Spirometry; United States; Vital Capacity | 2008 |
Agreement between two methods for assessing bioequivalence of inhaled salbutamol.
Topics: Administration, Inhalation; Adolescent; Adult; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Metered Dose Inhalers; Methacholine Chloride; Powders; Spirometry; Therapeutic Equivalency | 2008 |
Relationship between airway responsiveness to mannitol and to methacholine and markers of airway inflammation, peak flow variability and quality of life in asthma patients.
Topics: Adolescent; Adult; Asthma; Biomarkers; Drug Therapy, Combination; Eosinophils; Female; Humans; Male; Mannitol; Methacholine Chloride; Middle Aged; Nitric Oxide; Quality of Life; Sputum | 2008 |
TBXA2R gene polymorphism and responsiveness to leukotriene receptor antagonist in children with asthma.
Topics: Asthma; Case-Control Studies; Child; Exercise; Female; Genotype; Humans; Immunoglobulin E; Leukotriene Antagonists; Male; Methacholine Chloride; Polymorphism, Genetic; Receptors, Thromboxane A2, Prostaglandin H2 | 2008 |
Does measuring BHR add to guideline derived clinical measures in determining treatment for patients with persistent asthma?
Topics: Administration, Inhalation; Adolescent; Adult; Aged; Aged, 80 and over; Albuterol; Androstadienes; Anti-Asthmatic Agents; Area Under Curve; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bronchodilator Agents; Child; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluticasone; Humans; Latin America; Latvia; Male; Metered Dose Inhalers; Methacholine Chloride; Middle Aged; Patient Selection; Practice Guidelines as Topic; Salmeterol Xinafoate; Treatment Outcome; United States | 2008 |
Effects of exercise training and montelukast in children with mild asthma.
Topics: Acetates; Anti-Asthmatic Agents; Asthma; Asthma, Exercise-Induced; Breath Tests; Bronchoconstriction; Bronchospirometry; Child; Cyclopropanes; Exercise Test; Exercise Therapy; Exhalation; Female; Humans; Italy; Male; Methacholine Chloride; Physical Fitness; Quinolines; Sulfides | 2008 |
Diagnosing asthma in children: what is the role for methacholine bronchoprovocation testing?
Topics: Area Under Curve; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Child; Cohort Studies; Female; Humans; Male; Manitoba; Methacholine Chloride; Predictive Value of Tests; ROC Curve; Sensitivity and Specificity; Sex Factors; Skin Tests | 2008 |
Methacholine vs adenosine on intra and extrathoracic airway hyperresponsiveness in patients with cough variant asthma.
Topics: Adenosine Monophosphate; Adult; Aged; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cough; Cross-Over Studies; Female; Humans; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests | 2008 |
Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history.
Topics: Adolescent; Age Factors; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchodilator Agents; Budesonide; Child; Child, Preschool; Cohort Studies; Disease Progression; Double-Blind Method; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Least-Squares Analysis; Male; Methacholine Chloride; Nedocromil; Prognosis; Prospective Studies; Puberty; Sex Ratio; Vital Capacity | 2008 |
Effects of 0.1 ppm nitrogen dioxide on airways of normal and asthmatic subjects.
Topics: Adolescent; Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Humans; Male; Methacholine Chloride; Methacholine Compounds; Nitrogen Dioxide; Respiratory System | 1983 |
Relationship between bronchial responsiveness to hyperventilation with cold and methacholine in asthma.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Cold Temperature; Female; Forced Expiratory Volume; Humans; Hyperventilation; Male; Maximal Voluntary Ventilation; Methacholine Chloride; Methacholine Compounds | 1983 |
The effect of troleandomycin and methylprednisolone alone and in combination on bronchial sensitivity to methacholine.
Topics: Adult; Asthma; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Methylprednisolone; Placebos; Respiratory Function Tests; Troleandomycin | 1983 |
Methacholine dose-response curves in normal and asthmatic man: effect of starting conductance and pharmacological antagonism.
Topics: Adult; Airway Resistance; Albuterol; Asthma; Atropine; Bronchi; Chlorpheniramine; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Plethysmography, Whole Body | 1984 |
Bronchial challenge with formaldehyde gas: lack of bronchoconstriction in 13 patients suspected of having formaldehyde-induced asthma.
Topics: Adolescent; Adult; Aged; Asthma; Bronchi; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Formaldehyde; Gases; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Occupational Diseases | 1984 |
Effects of theophylline on inhaled methacholine and histamine in asthmatic children.
Topics: Adolescent; Asthma; Bronchi; Bronchial Provocation Tests; Child; Female; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Respiratory Function Tests; Theophylline | 1984 |
A double-blind study comparing the effectiveness of cromolyn sodium and sustained-release theophylline in childhood asthma.
Topics: Adolescent; Asthma; Child; Child, Preschool; Clinical Trials as Topic; Cromolyn Sodium; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Patient Compliance; Patient Dropouts; Random Allocation; Respiratory Function Tests; Seasons; Theophylline | 1984 |
Dose-dependent inhibition of cold air-induced bronchoconstriction by atropine.
Topics: Adult; Airway Resistance; Asthma; Atropine; Bronchi; Cold Temperature; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds | 1982 |
Asthma induced by cold air and its relation to nonspecific bronchial responsiveness to methacholine.
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Cold Temperature; Forced Expiratory Volume; Humans; Methacholine Chloride; Methacholine Compounds; Respiration | 1982 |
Effects of inhaled substance P on airway responsiveness to methacholine in asthmatic subjects in vivo.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Synergism; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Substance P | 1994 |
Regular formoterol treatment in mild asthma. Effect on bronchial responsiveness during and after treatment.
Topics: Adrenergic beta-Agonists; Adult; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Double-Blind Method; Ethanolamines; Female; Forced Expiratory Volume; Formoterol Fumarate; Humans; Male; Methacholine Chloride; Time Factors | 1995 |
Effects of a PAF antagonist, Y-24180, on bronchial hyperresponsiveness in patients with asthma.
Topics: Adult; Analysis of Variance; Asthma; Azepines; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Platelet Activating Factor; Platelet Aggregation Inhibitors; Triazoles | 1995 |
Salbutamol in the treatment of asthma.
Topics: Albuterol; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Double-Blind Method; Forced Expiratory Volume; Humans; Methacholine Chloride; Stereoisomerism; Sympathomimetics | 1995 |
Comparison of airway reactivity induced by cold air and metacholine challenges in asthmatic children.
Topics: Administration, Inhalation; Adolescent; Air; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Cold Temperature; Female; Forced Expiratory Flow Rates; Humans; Male; Methacholine Chloride; Spirometry | 1995 |
Interaction of inhaled beta 2 agonist and inhaled corticosteroid on airway responsiveness to allergen and methacholine.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Allergens; Analysis of Variance; Asthma; Bronchi; Bronchial Provocation Tests; Bronchodilator Agents; Budesonide; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Methacholine Chloride; Middle Aged; Pregnenediones | 1995 |
Rhinovirus inhalation causes long-lasting excessive airway narrowing in response to methacholine in asthmatic subjects in vivo.
Topics: Adult; Analysis of Variance; Asthma; Bronchial Diseases; Bronchial Provocation Tests; Common Cold; Constriction, Pathologic; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Rhinovirus; Time Factors | 1995 |
Rapid onset of tolerance to the bronchoprotective effect of salmeterol.
Topics: Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Drug Tolerance; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Prospective Studies; Salmeterol Xinafoate; Time Factors | 1995 |
Inhaled lysine acetylsalicylate (L-ASA) attenuates the bronchoconstrictor response to adenosine 5'-monophosphate (AMP) in asthmatic subjects.
Topics: Adenosine Monophosphate; Administration, Inhalation; Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interactions; Female; Histamine; Humans; Lysine; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests | 1995 |
Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration.
Topics: Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Humans; Male; Methacholine Chloride; Middle Aged; Muscle Relaxation; Muscle, Smooth | 1995 |
Adenosine, methacholine, and exercise challenges in children with asthma or paediatric chronic obstructive pulmonary disease.
Topics: Adenosine Monophosphate; Adolescent; Adult; Asthma; Bronchial Provocation Tests; Child; Diagnosis, Differential; Double-Blind Method; Exercise Test; Female; Humans; Lung Diseases, Obstructive; Male; Methacholine Chloride; Predictive Value of Tests; Sensitivity and Specificity | 1995 |
The severity of breathlessness during challenges with inhaled methacholine and hypertonic saline in atopic asthmatic subjects. The relationship with deep breath-induced bronchodilation.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Cross-Over Studies; Dyspnea; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Saline Solution, Hypertonic; Severity of Illness Index | 1995 |
Perception of bronchial obstruction in asthmatic patients. Relationship with bronchial eosinophilic inflammation and epithelial damage and effect of corticosteroid treatment.
Topics: Adrenal Cortex Hormones; Adult; Aged; Asthma; Bradykinin; Bronchi; Bronchoconstriction; Eosinophils; Epithelium; Female; Humans; Inflammation; Male; Methacholine Chloride; Middle Aged; Perception | 1995 |
Oral clonidine in patients with asthma: no significant effect on airway reactivity.
Topics: Adult; Airway Resistance; Asthma; Blood Pressure; Bronchial Hyperreactivity; Clonidine; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Respiratory Function Tests; Respiratory System; Vital Capacity | 1995 |
Allergen-induced hyperresponsiveness to bradykinin is more pronounced than that to methacholine.
Topics: Adult; Allergens; Asthma; Bradykinin; Bronchial Hyperreactivity; Cough; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Spirometry | 1995 |
Comparison of adenosine 5'-monophosphate and methacholine for the differentiation of asthma from chronic airway diseases with the use of the auscultative method in very young children.
Topics: Adenosine Monophosphate; Asthma; Auscultation; Bronchial Provocation Tests; Child, Preschool; Diagnosis, Differential; Double-Blind Method; Humans; Lung Diseases, Obstructive; Methacholine Chloride; Sensitivity and Specificity | 1995 |
Inhaled loop diuretics and basal airway responsiveness in man: evidence of a role for cyclo-oxygenase products.
Topics: Administration, Inhalation; Administration, Oral; Adult; Aerosols; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bumetanide; Double-Blind Method; Female; Flurbiprofen; Forced Expiratory Volume; Furosemide; Humans; Male; Methacholine Chloride; Prostaglandins | 1995 |
Changes in bronchial responsiveness, circulating leucocytes and ex vivo cytokine production by blood monocytes after PAF inhalation in allergic asthmatics.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-1; Leukocyte Count; Leukocytes, Mononuclear; Male; Methacholine Chloride; Platelet Activating Factor; Single-Blind Method; Tumor Necrosis Factor-alpha | 1995 |
Aerosolized acetaldehyde induces histamine-mediated bronchoconstriction in asthmatics.
Topics: Acetaldehyde; Adult; Aerosols; Analysis of Variance; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Dose-Response Relationship, Drug; Double-Blind Method; Forced Expiratory Volume; Histamine Release; Humans; Male; Methacholine Chloride; Terfenadine | 1993 |
Effect of inhaled heparin on methacholine-induced bronchial hyperreactivity.
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Over Studies; Female; Forced Expiratory Volume; Heparin; Humans; Male; Methacholine Chloride; Middle Aged; Single-Blind Method | 1995 |
Lack of bronchodilator effect after administration of subanaesthetic concentration of isoflurane in mild asthmatic subjects challenged with methacholine.
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Isoflurane; Male; Methacholine Chloride; Prospective Studies; Vital Capacity | 1995 |
Oral slow-release theophylline does not prevent early and late asthmatic response to allergen in sensitized subjects.
Topics: Administration, Oral; Adult; Allergens; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Theophylline; Time Factors | 1995 |
The reversibility of airway obstruction to an inhaled beta 2-adrenergic agent is less satisfactory after methacholine testing in asthmatic subjects.
Topics: Adult; Aged; Airway Obstruction; Albuterol; Asthma; Bronchial Provocation Tests; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged | 1995 |
Effect of three different doses of a slow-release theophylline formulation on bronchial response to inhaled methacholine in asthmatic patients.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Delayed-Action Preparations; Female; Humans; Male; Methacholine Chloride; Middle Aged; Theophylline | 1995 |
[New approaches to evaluation of nonspecific inhalation provocation (dose-response relationship) in the comparative evaluation of bronchial hyperreactivity within the scope of clinical trials].
Topics: Aerosols; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Methacholine Chloride | 1994 |
Comparison of two epidemiological protocols for measuring airway responsiveness and allergic sensitivity in adults.
Topics: Adolescent; Adult; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Middle Aged; Skin Tests | 1994 |
Effect of inhaled budesonide on seasonal changes in sensitivity and maximal response to methacholine in pollen-sensitive asthmatic subjects.
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Budesonide; Double-Blind Method; Female; Humans; Male; Methacholine Chloride; Middle Aged; Pollen; Pregnenediones; Seasons; Sensitivity and Specificity | 1994 |
U46619-induced bronchoconstriction in asthmatic subjects is mediated by acetylcholine release.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Cross-Over Studies; Double-Blind Method; Female; Humans; Ipratropium; Male; Methacholine Chloride; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2; Vasoconstrictor Agents | 1995 |
Asthma symptoms and airway hyperresponsiveness are lower during treatment with nedocromil sodium than during treatment with regular inhaled albuterol.
Topics: Administration, Inhalation; Adolescent; Adult; Aged; Albuterol; Analysis of Variance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Nedocromil; Statistics, Nonparametric; Time Factors | 1995 |
The effect of immunotherapy on bronchial hyperresponsiveness in asthmatic children.
Topics: Adolescent; Animals; Antigens; Antigens, Dermatophagoides; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Glycoproteins; Humans; Immunotherapy; Male; Methacholine Chloride; Middle Aged; Mites; Respiratory Function Tests | 1994 |
Effect of eight weeks of treatment with salmeterol on bronchoalveolar lavage inflammatory indices in asthmatics.
Topics: Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Female; Flow Cytometry; Humans; Male; Methacholine Chloride; Middle Aged; Salmeterol Xinafoate; Statistics, Nonparametric; Time Factors | 1994 |
Bronchial responsiveness is not always increased after allergen challenge.
Topics: Adolescent; Adult; Allergens; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Mites; Predictive Value of Tests; Time Factors | 1994 |
Partial inhibition of the early and late asthmatic response by a single dose of salmeterol.
Topics: Adrenergic beta-Agonists; Adult; Albuterol; Animals; Antigens, Dermatophagoides; Asthma; Blood Proteins; Bronchial Provocation Tests; Circadian Rhythm; Double-Blind Method; Eosinophil Granule Proteins; Eosinophil-Derived Neurotoxin; Eosinophils; Female; Forced Expiratory Volume; Glycoproteins; Humans; Leukocyte Count; Male; Methacholine Chloride; Mites; Neurotoxins; Ribonucleases; Salmeterol Xinafoate | 1994 |
Hypodense eosinophil number relates to clinical severity, airway hyperresponsiveness and response to inhaled corticosteroids in asthmatic subjects.
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Blood Proteins; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Budesonide; Cell Separation; Double-Blind Method; Eosinophil Granule Proteins; Eosinophils; Female; Forced Expiratory Volume; Humans; Leukocyte Count; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Pregnenediones; Ribonucleases | 1994 |
Effect of inhaled bradykinin on indices of airway responsiveness in asthmatic subjects.
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Bradykinin; Bronchial Provocation Tests; Bronchoconstriction; Double-Blind Method; Female; Forced Expiratory Volume; Histamine; Humans; Male; Maximal Expiratory Flow Rate; Methacholine Chloride; Total Lung Capacity; Vital Capacity | 1994 |
Age-related changes in bronchial hyperreactivity during the adolescent period.
Topics: Adolescent; Adult; Aging; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Female; Humans; Male; Methacholine Chloride; Prognosis; Severity of Illness Index | 1994 |
Effect of inhaled atrial natriuretic peptide on methacholine induced bronchoconstriction in asthma.
Topics: Administration, Inhalation; Adult; Asthma; Atrial Natriuretic Factor; Bronchoconstriction; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged | 1994 |
Postallergen inhaled budesonide reduces late asthmatic response and inhibits the associated increase of airway responsiveness to methacholine in asthmatics.
Topics: Administration, Inhalation; Adolescent; Adult; Allergens; Analysis of Variance; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Budesonide; Double-Blind Method; Dust; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Delayed; Male; Methacholine Chloride; Mites; Pregnenediones; Severity of Illness Index; Skin Tests; Time Factors | 1994 |
Refractory period during provocation with eucapnic hyperventilation and methacholine.
Topics: Adult; Aged; Analysis of Variance; Asthma; Bias; Bronchial Provocation Tests; Carbon Dioxide; Constriction, Pathologic; Female; Forced Expiratory Volume; Humans; Hyperventilation; Male; Methacholine Chloride; Middle Aged; Sensitivity and Specificity; Time Factors; Vital Capacity | 1994 |
Delivery of salbutamol by metered dose inhaler and valved spacer to wheezy infants: effect on bronchial responsiveness.
Topics: Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Double-Blind Method; Equipment Design; Humans; Infant; Methacholine Chloride; Nebulizers and Vaporizers; Respiration | 1993 |
Effects of inhaled steroids on blood eosinophils in moderate asthma.
Topics: Administration, Inhalation; Adult; Asthma; Beclomethasone; Double-Blind Method; Eosinophils; Female; Humans; Leukocyte Count; Leukotriene C4; Male; Methacholine Chloride | 1994 |
Nonbronchodilator effects of inhaled beta 2 agonists. Greater protection against adenosine monophosphate- than methacholine-induced bronchoconstriction in asthma.
Topics: Adenosine Monophosphate; Administration, Inhalation; Adult; Asthma; Bronchi; Bronchoconstriction; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Mast Cells; Methacholine Chloride; Sulfites; Terbutaline | 1994 |
Protective effect of albuterol delivered via a spacer device (Babyhaler) against methacholine induced bronchoconstriction in young wheezy children.
Topics: Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Child, Preschool; Double-Blind Method; Female; Humans; Male; Methacholine Chloride; Nebulizers and Vaporizers; Respiratory Sounds | 1994 |
Lack of effect of cetirizine on early and late asthmatic response after allergen challenge.
Topics: Adolescent; Adult; Allergens; Animals; Antigens, Dermatophagoides; Asthma; Blood Proteins; Bronchial Provocation Tests; Cetirizine; Double-Blind Method; Eosinophil Granule Proteins; Eosinophils; Female; Forced Expiratory Volume; Glycoproteins; Humans; Lung; Male; Methacholine Chloride; Mites; Ribonucleases | 1994 |
Potentiating effect of inhaled acetaldehyde on bronchial responsiveness to methacholine in asthmatic subjects.
Topics: Acetaldehyde; Adult; Aged; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Double-Blind Method; Drug Synergism; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Terfenadine | 1994 |
Effect of an oral gold compound, auranofin, on non-specific bronchial hyperresponsiveness in mild asthma.
Topics: Adult; Asthma; Auranofin; Bronchial Hyperreactivity; Double-Blind Method; Humans; Methacholine Chloride; Middle Aged; Respiratory Function Tests; Time Factors | 1994 |
Effects of acute allergen exposure on posture-induced changes in airway responsiveness to methacholine in asthma.
Topics: Adult; Airway Obstruction; Allergens; Asthma; Bronchoconstriction; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Posture; Respiratory Physiological Phenomena; Respiratory System; Supine Position; Time Factors | 1994 |
Effect of a single dose of inhaled salmeterol on baseline airway caliber and methacholine-induced airway obstruction in asthmatic children.
Topics: Administration, Inhalation; Adolescent; Adrenergic beta-Agonists; Airway Obstruction; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Bronchodilator Agents; Child; Double-Blind Method; Female; Humans; Male; Methacholine Chloride; Respiratory Function Tests; Salmeterol Xinafoate; Survival Analysis | 1993 |
Leukotriene E4 and granulocytic infiltration into asthmatic airways.
Topics: Adult; Asthma; Bronchial Provocation Tests; Eosinophils; Female; Granulocytes; Humans; Leukotriene E4; Male; Methacholine Chloride; Middle Aged; Mucous Membrane; Neutrophils; SRS-A | 1993 |
The effect of H1-receptor blockade on the development of early- and late-phase bronchoconstriction and increased bronchial responsiveness in allergen-induced asthma.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Double-Blind Method; Female; Forced Expiratory Volume; Histamine; Histamine H1 Antagonists; Humans; Male; Methacholine Chloride; Phthalazines; Prostaglandin D2 | 1993 |
Regular inhaled salbutamol and airway responsiveness to allergen.
Topics: Administration, Inhalation; Adolescent; Adult; Albuterol; Allergens; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Double-Blind Method; Drug Tolerance; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged | 1993 |
Eucapnic voluntary hyperventilation as a bronchoprovocation technique. Comparison with methacholine inhalation in asthmatics.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Humans; Hyperventilation; Male; Methacholine Chloride; Prospective Studies; Sensitivity and Specificity | 1994 |
Effect of alterations of dietary sodium on the severity of asthma in men.
Topics: Adolescent; Adult; Aged; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Child; Double-Blind Method; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Sodium, Dietary | 1993 |
Peak flow variation in childhood asthma: a three-year analysis.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Child, Preschool; Cross-Sectional Studies; Double-Blind Method; Follow-Up Studies; Humans; Immunotherapy; Longitudinal Studies; Lung; Methacholine Chloride; Peak Expiratory Flow Rate | 1994 |
Relaxation and music therapies for asthma among patients prestabilized on asthma medication.
Topics: Adolescent; Adult; Aged; Asthma; Humans; Methacholine Chloride; Middle Aged; Music; Pulmonary Ventilation; Relaxation Therapy; Respiratory Function Tests; Self-Assessment; Spirometry; Treatment Outcome | 1994 |
The determinants of airway hyperresponsiveness to hypertonic saline in atopic asthma in vivo. Relationship with sub-populations of peripheral blood leucocytes.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dose-Response Relationship, Immunologic; Female; Humans; Leukocyte Count; Leukocytes; Male; Methacholine Chloride; Saline Solution, Hypertonic; T-Lymphocyte Subsets | 1993 |
Effect of multiple doses of nedocromil sodium given after allergen inhalation in asthma.
Topics: Adult; Allergens; Animals; Asthma; Bronchial Provocation Tests; Double-Blind Method; Drug Administration Schedule; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Mites; Nedocromil; Time Factors | 1993 |
Airway inflammation in symptomatic and asymptomatic children with methacholine hyperresponsiveness.
Topics: Administration, Inhalation; Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Budesonide; Child; Eosinophils; Female; Humans; Leukocyte Count; Male; Methacholine Chloride; Pregnenediones | 1993 |
Changes in methacholine induced bronchoconstriction with the long acting beta 2 agonist salmeterol in mild to moderate asthmatic patients.
Topics: Adult; Albuterol; Asthma; Bronchoconstriction; Bronchodilator Agents; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers; Salmeterol Xinafoate | 1993 |
Effect of inhaled prostaglandin E2 on allergen-induced asthma.
Topics: Administration, Inhalation; Adult; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dinoprostone; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Time Factors | 1993 |
Influence of posture on expiratory flows and airway responsiveness to methacholine in asthma.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Posture; Supine Position; Time Factors | 1993 |
Lack of short-term effect of the thromboxane synthetase inhibitor UK-38,485 on airway reactivity to methacholine in asthmatic subjects.
Topics: Adult; Asthma; Bronchial Provocation Tests; Double-Blind Method; Female; Humans; Imidazoles; Male; Methacholine Chloride; Middle Aged; Thromboxane A2; Thromboxane-A Synthase; Time Factors | 1993 |
Effects of inhaled beclomethasone on airway responsiveness in occupational asthma. Placebo-controlled study of subjects sensitized to toluene diisocyanate.
Topics: Adolescent; Adult; Asthma; Beclomethasone; Bronchial Hyperreactivity; Bronchial Provocation Tests; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Hydrocortisone; Hypoglycemia; Insulin; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Placebos; Toluene 2,4-Diisocyanate | 1993 |
Treatment of allergic rhinitis with intranasal corticosteroids in patients with mild asthma: effect on lower airway responsiveness.
Topics: Administration, Intranasal; Adolescent; Analysis of Variance; Asthma; Beclomethasone; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Circadian Rhythm; Double-Blind Method; Humans; Methacholine Chloride; Rhinitis, Allergic, Seasonal; Time Factors | 1993 |
Effect of inhaled amiloride on the bronchial response to methacholine and cold air hyperventilation challenges.
Topics: Administration, Inhalation; Adult; Amiloride; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Cold Temperature; Double-Blind Method; Forced Expiratory Volume; Humans; Hyperventilation; Male; Methacholine Chloride | 1993 |
Effect of inhaled corticosteroids on peripheral blood eosinophil counts and density profiles in asthma.
Topics: Administration, Inhalation; Adult; Aerosols; Asthma; Blood Cell Count; Bronchial Provocation Tests; Budesonide; Double-Blind Method; Eosinophils; Female; Humans; Male; Methacholine Chloride; Middle Aged; Pregnenediones | 1993 |
The effect of salbutamol controlled release on airways responsiveness to inhaled methacholine in mild asthmatic subjects.
Topics: Adult; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Delayed-Action Preparations; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride | 1993 |
Theophylline--an immunomodulatory role in asthma?
Topics: Adjuvants, Immunologic; Administration, Oral; Adolescent; Adult; Allergens; Animals; Asthma; Bronchial Provocation Tests; Delayed-Action Preparations; Double-Blind Method; Drug Evaluation; Dust; Forced Expiratory Volume; Humans; Leukocyte Count; Lung; Methacholine Chloride; Middle Aged; Mites; T-Lymphocyte Subsets; Theophylline | 1993 |
Should we monitor peak expiratory flow rates or record symptoms with a simple diary in the management of asthma?
Topics: Adult; Aged; Asthma; Bronchial Provocation Tests; Female; Humans; Male; Medical Records; Methacholine Chloride; Middle Aged; Monitoring, Physiologic; Patient Compliance; Peak Expiratory Flow Rate; Single-Blind Method; Spirometry | 1993 |
Minor acute effect of an inhaled corticosteroid (budesonide) on bronchial hyperresponsiveness to methacholine in children with asthma.
Topics: Aerosols; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Budesonide; Child; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Pregnenediones | 1993 |
Effect of an oral potassium channel activator, BRL 38227, on airway function and responsiveness in asthmatic patients: comparison with oral salbutamol.
Topics: Adult; Asthma; Benzopyrans; Bronchodilator Agents; Cromakalim; Double-Blind Method; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Middle Aged; Pyrroles; Time Factors; Vital Capacity | 1993 |
Regular inhaled beta agonist in asthma: effects on exacerbations and lung function.
Topics: Administration, Inhalation; Adolescent; Adult; Albuterol; Asthma; Bronchoconstriction; Double-Blind Method; Female; Fenoterol; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Terbutaline; Time Factors; Vital Capacity | 1993 |
Effect of a leukotriene antagonist, ONO-1078, on bronchial hyperresponsiveness in patients with asthma.
Topics: Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Chromones; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Middle Aged; SRS-A; Vital Capacity | 1993 |
Beclomethasone given after the early asthmatic response inhibits the late response and the increased methacholine responsiveness and cromolyn does not.
Topics: Adolescent; Adult; Asthma; Beclomethasone; Bronchial Provocation Tests; Cromolyn Sodium; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride | 1993 |
The effect of nedocromil sodium on childhood asthma during the viral season.
Topics: Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Child; Double-Blind Method; Female; Humans; Male; Methacholine Chloride; Nedocromil; Peak Expiratory Flow Rate; Respiratory Tract Infections; Virus Diseases | 1995 |
Long-term circadian effects of salmeterol in asthmatic children treated with inhaled corticosteroids.
Topics: Administration, Inhalation; Adolescent; Albuterol; Asthma; Beclomethasone; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Child; Circadian Rhythm; Double-Blind Method; Female; Forced Expiratory Volume; Glucocorticoids; Humans; Male; Methacholine Chloride; Salmeterol Xinafoate | 1995 |
The effect of ozone exposure on allergen responsiveness in subjects with asthma or rhinitis.
Topics: Adult; Air; Allergens; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Ozone; Physical Exertion; Respiration; Rhinitis, Allergic, Perennial; Time Factors | 1996 |
Rebound airway obstruction and responsiveness after cessation of terbutaline: effects of budesonide.
Topics: Administration, Inhalation; Administration, Topical; Adolescent; Adrenergic beta-Agonists; Adult; Aerosols; Anti-Inflammatory Agents; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Budesonide; Double-Blind Method; Female; Forced Expiratory Volume; Glucocorticoids; Humans; Ipratropium; Male; Methacholine Chloride; Middle Aged; Placebos; Pregnenediones; Terbutaline; Time Factors | 1996 |
Long term clinical comparison of single versus twice daily administration of inhaled budesonide in moderate asthma.
Topics: Administration, Inhalation; Adult; Aged; Asthma; Bronchodilator Agents; Budesonide; Double-Blind Method; Drug Administration Schedule; Female; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Pregnenediones; Spirometry; Time Factors | 1995 |
Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa.
Topics: Adult; Asthma; Biopsy; Bronchi; Bronchial Provocation Tests; Bronchoscopy; Chymases; Cytokines; Double-Blind Method; Eosinophils; Female; Gene Expression; Glucocorticoids; Humans; Immunohistochemistry; In Situ Hybridization; Inflammation Mediators; Interferon-gamma; Interleukin-4; Interleukin-5; Male; Mast Cells; Methacholine Chloride; Mucous Membrane; Prednisolone; RNA, Messenger; Serine Endopeptidases; T-Lymphocytes; Tryptases | 1996 |
Airway reactivity changes in asthmatic patients undergoing blinded food challenges.
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Child, Preschool; Double-Blind Method; Food Hypersensitivity; Forced Expiratory Volume; Humans; Methacholine Chloride; Skin Tests; Spirometry | 1996 |
Salbutamol-induced increased airway responsiveness to allergen and reduced protection versus methacholine: dose response.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Albuterol; Allergens; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Humans; Methacholine Chloride; Middle Aged | 1996 |
Effect of regular inhaled beclomethasone on exercise and methacholine airway responses in school children with recurrent wheeze.
Topics: Administration, Inhalation; Administration, Topical; Analysis of Variance; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Asthma, Exercise-Induced; Beclomethasone; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Double-Blind Method; Exercise; Female; Forced Expiratory Volume; Glucocorticoids; Humans; Male; Methacholine Chloride; Prospective Studies; Recurrence; Respiratory Mechanics; Respiratory Sounds | 1995 |
Angiotensin II potentiates methacholine-induced bronchoconstriction in human airway both in vitro and in vivo.
Topics: Adult; Analysis of Variance; Angiotensin II; Asthma; Bronchi; Bronchoconstriction; Bronchoconstrictor Agents; Double-Blind Method; Drug Synergism; Female; Humans; In Vitro Techniques; Male; Methacholine Chloride; Muscle, Smooth; Stimulation, Chemical | 1995 |
Reduced dose salbutamol in comparison with standard dosage for symptom relief in asthma.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Aged; Albuterol; Analysis of Variance; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate | 1995 |
Methacholine challenge does not affect bronchoalveolar fluid cell number and many indices of cell function in asthma.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Bronchoscopy; Cell Count; Female; Humans; Leukocytes; Macrophages; Male; Mast Cells; Methacholine Chloride; Middle Aged | 1995 |
Inhaled corticosteroids do not prevent the development of tolerance to the bronchoprotective effect of salmeterol.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Aged; Albuterol; Anti-Asthmatic Agents; Asthma; Beclomethasone; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Budesonide; Cross-Over Studies; Double-Blind Method; Drug Tolerance; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Placebos; Pregnenediones; Salmeterol Xinafoate; Tachyphylaxis | 1996 |
Effect of inhaled corticosteroids on bronchial hyperresponsiveness in patients with mild asthma.
Topics: Adult; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bronchodilator Agents; Budesonide; Double-Blind Method; Female; Humans; Male; Methacholine Chloride; Pregnenediones; Pulmonary Ventilation | 1995 |
Randomised double-blind placebo-controlled study of the effect of inhibition of nitric oxide synthesis in bradykinin-induced asthma.
Topics: Adult; Aerosols; Arginine; Asthma; Bradykinin; Bronchial Provocation Tests; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Lung Volume Measurements; Male; Methacholine Chloride; Middle Aged; Nitric Oxide Synthase; omega-N-Methylarginine | 1996 |
Prevalence and treatment of chronic airways obstruction in adults over the age of 45.
Topics: Aged; Aged, 80 and over; Asthma; Bronchitis; Bronchoconstrictor Agents; Bronchodilator Agents; England; Female; Forced Expiratory Volume; Humans; Lung Diseases, Obstructive; Male; Methacholine Chloride; Middle Aged; Prevalence; Spirometry; Vital Capacity | 1996 |
Effect of ethanol on airway caliber and nonspecific bronchial responsiveness in patients with alcohol-induced asthma.
Topics: Administration, Inhalation; Asthma; Bronchi; Bronchial Provocation Tests; Cross-Over Studies; Double-Blind Method; Ethanol; Forced Expiratory Volume; Humans; Methacholine Chloride; Placebos; Respiratory Function Tests; Sodium Chloride | 1996 |
Controlled-release theophylline inhibits early morning airway obstruction and hyperresponsiveness in asthmatic subjects.
Topics: Administration, Inhalation; Administration, Oral; Adult; Airway Obstruction; Asthma; Circadian Rhythm; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Female; Forced Expiratory Volume; Headache; Humans; Male; Methacholine Chloride; Middle Aged; Nausea; Theophylline; Tremor | 1996 |
The effect of inhaled heparin on bronchial reactivity to sodium metabisulphite and methacholine in patients with asthma.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fibrinolytic Agents; Forced Expiratory Volume; Heparin; Humans; Male; Methacholine Chloride; Muscle, Smooth; Nebulizers and Vaporizers; Sulfites | 1996 |
Inhaled lysine acetylsalicylate (L-ASA) attenuates histamine-induced bronchoconstriction in asthma.
Topics: Administration, Inhalation; Adult; Aspirin; Asthma; Bronchoconstriction; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine; Humans; Lysine; Male; Methacholine Chloride; Middle Aged | 1996 |
Changes in neurokinin A airway responsiveness with inhaled lysine-acetylsalicylate in asthma.
Topics: Administration, Inhalation; Adult; Aspirin; Asthma; Bronchial Provocation Tests; Constriction, Pathologic; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Humans; Lysine; Male; Methacholine Chloride; Middle Aged; Neurokinin A; Respiratory Function Tests | 1996 |
Involvement of thromboxane A2 in bronchial hyperresponsiveness of asthma. Kanazawa Asthma Research Group.
Topics: Adolescent; Adult; Airway Resistance; Asthma; Bridged Bicyclo Compounds; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Carbazoles; Cross-Over Studies; Double-Blind Method; Fatty Acids, Monounsaturated; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Prostaglandin Antagonists; Sulfonamides; Thromboxane A2 | 1995 |
Lung mechanics during induced bronchoconstriction.
Topics: Adenosine Triphosphate; Adult; Airway Resistance; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Constriction, Pathologic; Female; Forced Expiratory Volume; Histamine; Humans; Lung; Male; Methacholine Chloride; Respiratory Mechanics; Smoking; Spirometry; Tidal Volume; Total Lung Capacity | 1996 |
Serum eosinophil cationic protein (ECP) as a marker of disease activity and treatment efficacy in seasonal asthma.
Topics: Adult; Albuterol; Anti-Asthmatic Agents; Asthma; Beclomethasone; Biomarkers; Blood Proteins; Bronchial Provocation Tests; Bronchodilator Agents; Double-Blind Method; Eosinophil Granule Proteins; Eosinophils; Female; Forced Expiratory Volume; Humans; Leukocyte Count; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Pollen; Ribonucleases; Seasons; Skin Tests | 1996 |
Prolonged effect of tiotropium bromide on methacholine-induced bronchoconstriction in asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cholinergic Antagonists; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Methacholine Chloride; Scopolamine Derivatives; Time Factors; Tiotropium Bromide | 1996 |
Diurnal change of bronchial caliber and airway responsiveness in asthmatics during long-term treatment with long-acting beta 2-agonist salmeterol.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Analysis of Variance; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bronchodilator Agents; Circadian Rhythm; Drug Interactions; Female; Humans; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Salmeterol Xinafoate | 1996 |
Human airway narrowing measured using high resolution computed tomography.
Topics: Adult; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Bronchography; Humans; Methacholine Chloride; Middle Aged; Respiratory Function Tests; Tomography, X-Ray Computed | 1996 |
Effects of fluticasone propionate on methacholine dose-response curves in nonsmoking atopic asthmatics.
Topics: Administration, Topical; Adolescent; Adult; Androstadienes; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fluticasone; Forced Expiratory Volume; Glucocorticoids; Humans; Male; Methacholine Chloride; Middle Aged | 1996 |
Salmeterol tachyphylaxis in steroid treated asthmatic subjects.
Topics: Administration, Topical; Adult; Albuterol; Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Double-Blind Method; Female; Follow-Up Studies; Forced Expiratory Volume; Glucocorticoids; Humans; Male; Methacholine Chloride; Middle Aged; Salmeterol Xinafoate; Tachyphylaxis | 1996 |
An inhaled glucocorticoid does not prevent tolerance to the bronchoprotective effect of a long-acting inhaled beta 2-agonist.
Topics: Administration, Inhalation; Administration, Topical; Adrenergic beta-Agonists; Adult; Albuterol; Anti-Inflammatory Agents; Asthma; Bronchoconstriction; Bronchodilator Agents; Budesonide; Cross-Over Studies; Double-Blind Method; Drug Tolerance; Female; Forced Expiratory Volume; Glucocorticoids; Humans; Male; Methacholine Chloride; Pregnenediones; Salmeterol Xinafoate | 1996 |
Tolerance to the protective effect of salmeterol on allergen challenge.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Albuterol; Allergens; Asthma; Bronchial Provocation Tests; Drug Tolerance; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Salmeterol Xinafoate; Single-Blind Method | 1996 |
Effect of allergen challenge on airway responsiveness to histamine and sodium metabisulphite in mild asthma.
Topics: Adult; Allergens; Asthma; Bronchial Provocation Tests; Cross-Over Studies; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Random Allocation; Single-Blind Method; Sulfites | 1996 |
Effect of 3 hours' passive smoke exposure in the evening on airway tone and responsiveness until next morning.
Topics: Adult; Analysis of Variance; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Tobacco Smoke Pollution; Vital Capacity | 1997 |
Does ketotifen have a steroid-sparing effect in childhood asthma?
Topics: Administration, Inhalation; Administration, Topical; Adolescent; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Beclomethasone; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Budesonide; Child; Circadian Rhythm; Double-Blind Method; Female; Forced Expiratory Volume; Glucocorticoids; Histamine H1 Antagonists; Humans; Ketotifen; Lung; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Placebos; Pregnenediones | 1997 |
Effects of long-acting and short-acting beta-agonists on methacholine dose-response curves in asthmatics.
Topics: Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Salmeterol Xinafoate | 1997 |
The effectiveness of once-daily dosing of inhaled flunisolide in maintaining asthma control.
Topics: Administration, Inhalation; Adolescent; Adult; Albuterol; Anti-Inflammatory Agents; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Child; Double-Blind Method; Female; Fluocinolone Acetonide; Forced Expiratory Volume; Humans; Hydrocortisone; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate | 1997 |
Time course of changes in adenosine 5'-monophosphate airway responsiveness with inhaled heparin in allergic asthma.
Topics: Adenosine Monophosphate; Administration, Inhalation; Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Female; Forced Expiratory Volume; Heparin; Humans; Male; Methacholine Chloride; Radioallergosorbent Test; Skin Tests; Time Factors | 1997 |
Protective effect of inhaled budesonide against unlimited airway narrowing to methacholine in atopic patients with asthma.
Topics: Adult; Anti-Inflammatory Agents; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Budesonide; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Pregnenediones | 1997 |
The relationship between airway hyperreactivity (AHR) and sodium, potassium adenosine triphosphatase (Na+,K+ ATPase) enzyme inhibition.
Topics: Adult; Animals; Asthma; Blood Platelets; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dose-Response Relationship, Immunologic; Double-Blind Method; Dust; Enzyme Inhibitors; Forced Expiratory Volume; Humans; Methacholine Chloride; Mites; Ouabain; Pollen; Respiratory Hypersensitivity; Skin Tests; Sodium-Potassium-Exchanging ATPase | 1997 |
Reduced asthma symptoms with n-3 fatty acid ingestion are related to 5-series leukotriene production.
Topics: Adult; Asthma; Biomarkers; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Fatty Acids, Omega-3; Forced Expiratory Volume; Humans; Leukotrienes; Methacholine Chloride; Predictive Value of Tests; Respiration; Time Factors; Vital Capacity | 1997 |
Fluticasone propionate, salmeterol xinafoate, and their combination in the treatment of nocturnal asthma.
Topics: Adenosine Monophosphate; Administration, Inhalation; Administration, Topical; Adrenergic beta-Agonists; Adult; Albuterol; Androstadienes; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Circadian Rhythm; Double-Blind Method; Drug Therapy, Combination; Female; Fluticasone; Glucocorticoids; Humans; Male; Methacholine Chloride; Salmeterol Xinafoate | 1997 |
The effect of inhaled leukotriene D4 and methacholine on sputum cell differentials in asthma.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cell Count; Cross-Over Studies; Eosinophils; Female; Humans; Leukotriene D4; Male; Methacholine Chloride; Pulmonary Eosinophilia; Sputum | 1997 |
The effect of salmeterol on nocturnal symptoms, airway function, and inflammation in asthma.
Topics: Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Blood Proteins; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Bronchodilator Agents; Bronchoscopy; Cell Count; Circadian Rhythm; Cross-Over Studies; Double-Blind Method; Eosinophil Granule Proteins; Eosinophils; Female; Follow-Up Studies; Forced Expiratory Volume; Glycoproteins; Humans; Inflammation; Inflammation Mediators; Leukotriene B4; Lung; Lysophospholipase; Male; Methacholine Chloride; Placebos; Ribonucleases; Salmeterol Xinafoate; Sleep; Spirometry; Thromboxane B2 | 1997 |
Activity of inhaled lysine acetylsalicylate (L-ASA) on bradykinin-induced bronchoconstriction in asthmatics: evidence of contribution of prostaglandins.
Topics: Administration, Inhalation; Adult; Airway Resistance; Analysis of Variance; Aspirin; Asthma; Bradykinin; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Lysine; Male; Methacholine Chloride; Middle Aged; Prostaglandins | 1997 |
Speeds of action of single doses of formoterol and salbutamol compared with placebo in reversing methacholine-induced bronchoconstriction.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Albuterol; Asthma; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Ethanolamines; Female; Formoterol Fumarate; Humans; Male; Methacholine Chloride; Middle Aged; Placebos | 1996 |
Effect of acute alterations in inspired oxygen tension on methacholine induced bronchoconstriction in patients with asthma.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Double-Blind Method; Female; Forced Expiratory Volume; Heart Rate; Humans; Male; Methacholine Chloride; Oxygen | 1997 |
Inhibitory effects of an anti-IgE antibody E25 on allergen-induced early asthmatic response.
Topics: Adult; Allergens; Antibodies, Monoclonal; Asthma; Double-Blind Method; Female; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Male; Methacholine Chloride; Middle Aged | 1997 |
Effect of short-term treatment with low-dose inhaled fluticasone propionate on airway inflammation and remodeling in mild asthma: a placebo-controlled study.
Topics: Administration, Inhalation; Adolescent; Adult; Androstadienes; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchi; Bronchitis; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fluticasone; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Placebos; Time Factors | 1997 |
Attenuation of early and late phase allergen-induced bronchoconstriction in asthmatic subjects by a 5-lipoxygenase activating protein antagonist, BAYx 1005.
Topics: Adult; Area Under Curve; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Lipoxygenase Inhibitors; Male; Methacholine Chloride; Quinolines | 1997 |
Ineffectiveness of a four week treatment with the thromboxane synthetase inhibitor, imidazole salycilate, in reducing airway hyperresponsiveness to methacholine in asthmatics.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Female; Forced Expiratory Volume; Humans; Imidazoles; Male; Methacholine Chloride; Middle Aged; Thromboxane-A Synthase; Treatment Failure | 1997 |
Comparison of inflammatory cell counts in asthma: induced sputum vs bronchoalveolar lavage and bronchial biopsies.
Topics: Adolescent; Adult; Asthma; Biopsy; Bronchi; Bronchoalveolar Lavage Fluid; Female; Humans; Leukocyte Count; Leukocytes; Macrophages, Alveolar; Male; Methacholine Chloride; Sputum | 1997 |
Effect of pretreatment with heparin on pulmonary and cutaneous response.
Topics: Administration, Inhalation; Adolescent; Adult; Aged; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Calcium Channels; Cross-Over Studies; Dermatitis, Atopic; Double-Blind Method; Female; Heparin; Histamine; Humans; Injections, Intravenous; Inositol 1,4,5-Trisphosphate Receptors; Male; Methacholine Chloride; Middle Aged; Premedication; Receptors, Cytoplasmic and Nuclear; Respiratory Function Tests; Skin Tests | 1997 |
Evaluation of single-dose inhaled corticosteroid activity with an allergen challenge model.
Topics: Administration, Inhalation; Administration, Topical; Adult; Allergens; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Budesonide; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Female; Forced Expiratory Volume; Glucocorticoids; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride; Pregnenediones | 1997 |
Endothelin-1-induced bronchoconstriction in asthma.
Topics: Adult; Aerosols; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Double-Blind Method; Endothelin-1; Female; Humans; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests; Single-Blind Method; Statistics, Nonparametric; Time Factors | 1997 |
Effects of ketotifen on symptoms and on bronchial mucosa in patients with atopic asthma.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Anti-Allergic Agents; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Asthma; Biopsy; Blood Proteins; Bronchi; Bronchial Provocation Tests; Bronchoscopy; Cytarabine; Double-Blind Method; Doxorubicin; Eosinophil Granule Proteins; Female; Forced Expiratory Volume; Humans; Immunohistochemistry; Inflammation; Ketotifen; Leukocyte Elastase; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Ribonucleases; T-Lymphocytes | 1997 |
Interpretation of positive results of a methacholine inhalation challenge and 1 week of inhaled bronchodilator use in diagnosing and treating cough-variant asthma.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Aged; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Cough; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Metaproterenol; Methacholine Chloride; Middle Aged; Prospective Studies; Time Factors | 1997 |
Effect of regular salmeterol treatment on albuterol-induced bronchoprotection in mild asthma.
Topics: Adenosine Monophosphate; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Salmeterol Xinafoate | 1997 |
The effect of azelastine on the infiltration of inflammatory cells into the bronchial mucosa and clinical changes in patients with bronchial asthma.
Topics: Adolescent; Adult; Antigens, CD; Asthma; Bronchi; Bronchial Provocation Tests; Bronchodilator Agents; Double-Blind Method; Eosinophils; Female; Humans; Immunity, Mucosal; Immunohistochemistry; Leukocytes; Macrophages; Male; Mast Cells; Methacholine Chloride; Middle Aged; Mucous Membrane; Peak Expiratory Flow Rate; Phthalazines; T-Lymphocytes | 1997 |
Bronchial asthma and airway hyperresponsiveness at high altitude.
Topics: Adult; Altitude; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Humans; Male; Methacholine Chloride; Middle Aged; Muscarinic Antagonists; Prospective Studies | 1997 |
Effect of single doses of S-salbutamol, R-salbutamol, racemic salbutamol, and placebo on the airway response to methacholine.
Topics: Adult; Akathisia, Drug-Induced; Albuterol; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Methacholine Chloride; Pulse; Stereoisomerism | 1997 |
Effect of regular inhaled albuterol on allergen-induced late responses and sputum eosinophils in asthmatic subjects.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Allergens; Asthma; Blood Proteins; Bronchial Provocation Tests; Bronchoconstriction; Cross-Over Studies; Double-Blind Method; Eosinophil Granule Proteins; Eosinophils; Female; Forced Expiratory Volume; Humans; Inflammation Mediators; Male; Methacholine Chloride; Ribonucleases; Sputum | 1997 |
Neutral endopeptidase inhibition with inhaled phosphoramidon: no effect on bronchial responsiveness to adenosine 5'-monophosphate (AMP) in asthma.
Topics: Adenosine Monophosphate; Administration, Inhalation; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Double-Blind Method; Female; Glycopeptides; Humans; Male; Methacholine Chloride; Neprilysin; Protease Inhibitors | 1997 |
Pulmonary dysanapsis, methacholine airway responsiveness and sensitization to airborne antigen.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Air Pollutants; Airway Resistance; Antigens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Female; Humans; Hypersensitivity, Immediate; Immunization; Lung; Male; Methacholine Chloride; Middle Aged; Pedigree; Regression Analysis; Respiratory Function Tests; Sex Factors | 1997 |
Tolerance to the bronchoprotective effect of salmeterol 12 hours after starting twice daily treatment.
Topics: Administration, Inhalation; Adrenergic beta-Antagonists; Adult; Albuterol; Asthma; Bronchi; Bronchial Provocation Tests; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Drug Tolerance; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Salmeterol Xinafoate | 1998 |
Effect of once daily and twice daily sustained release theophylline formulations on daytime variation of bronchial hyperresponsiveness in asthmatic patients.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Administration Schedule; Female; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Spirometry; Theophylline | 1997 |
Dose equivalence and bronchoprotective effects of salmeterol and salbutamol in asthma.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Salmeterol Xinafoate | 1997 |
Breathing pattern variability during bronchial histamine and methacholine challenges in asthmatics.
Topics: Administration, Inhalation; Adolescent; Adult; Airway Resistance; Analysis of Variance; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Plethysmography; Reproducibility of Results; Respiratory Mechanics | 1996 |
Hyperventilation during bronchial challenges in asthmatics: reproducibility and assessment of contributing factors.
Topics: Administration, Inhalation; Adolescent; Airway Resistance; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Histamine; Humans; Hyperventilation; Linear Models; Male; Methacholine Chloride; Plethysmography; Reproducibility of Results; Risk Assessment | 1996 |
Differences in sensitivity, maximal response and position of the concentration-response curve to methacholine between asthmatics, patients with allergic rhinitis and healthy subjects.
Topics: Adult; Analysis of Variance; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Respiratory Function Tests; Rhinitis; Sensitivity and Specificity; Skin Tests | 1998 |
Posthyperventilation hypoxemia after methacholine inhalation.
Topics: Administration, Inhalation; Adult; Aged; Asthma; Bronchoconstrictor Agents; Carbon Dioxide; Female; Humans; Hyperventilation; Hypoxia; Male; Methacholine Chloride; Middle Aged; Oxygen; Pulmonary Gas Exchange; Time Factors | 1998 |
Dose-related response to inhaled fluticasone propionate in patients with methacholine-induced bronchial hyperresponsiveness: a double-blind, placebo-controlled study.
Topics: Administration, Inhalation; Administration, Topical; Adult; Androstadienes; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fluticasone; Glucocorticoids; Humans; Male; Methacholine Chloride; Respiratory Function Tests | 1998 |
Nebulized glucagon in the treatment of bronchospasm in asthmatic patients.
Topics: Administration, Inhalation; Adolescent; Adult; Anti-Asthmatic Agents; Asthma; Bronchial Spasm; Bronchoconstrictor Agents; Bronchospirometry; Child; Cross-Over Studies; Double-Blind Method; Female; Glucagon; Humans; Male; Methacholine Chloride; Time Factors; Treatment Outcome | 1998 |
Methacholine provocations do not reveal sensitivity to strong scents.
Topics: Adult; Asthma; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Nasal Provocation Tests; Perfume | 1998 |
A comparison of regular salmeterol vs 'as required' salbutamol therapy in asthmatic children.
Topics: Adolescent; Adrenergic beta-Agonists; Albuterol; Analysis of Variance; Asthma; Bronchoconstrictor Agents; Child; Double-Blind Method; Drug Administration Schedule; Female; Humans; Lung; Male; Methacholine Chloride; Nebulizers and Vaporizers; Peak Expiratory Flow Rate; Salmeterol Xinafoate | 1998 |
Effect of inhaled interleukin-4 on airway hyperreactivity in asthmatics.
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Eosinophils; Female; Humans; Interleukin-4; Leukocyte Count; Male; Methacholine Chloride; Middle Aged; Recombinant Proteins; Sputum | 1998 |
Effect of an inhaled glucocorticosteroid on mast cell and smooth muscle beta 2 adrenergic tolerance in mild asthma.
Topics: Adenosine Monophosphate; Administration, Inhalation; Administration, Topical; Adrenergic beta-Agonists; Adult; Anti-Inflammatory Agents; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Budesonide; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Drug Tolerance; Female; Glucocorticoids; Humans; Lung; Male; Mast Cells; Methacholine Chloride; Middle Aged; Muscle, Smooth; Terbutaline | 1998 |
Effects of treatment with formoterol on bronchoprotection against methacholine.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Anti-Inflammatory Agents; Asthma; Bronchoconstrictor Agents; Bronchodilator Agents; Double-Blind Method; Drug Therapy, Combination; Ethanolamines; Female; Forced Expiratory Volume; Formoterol Fumarate; Humans; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Steroids; Terbutaline; Time Factors | 1998 |
Tolerance to the protective effects of salmeterol on methacholine-induced bronchoconstriction: influence of inhaled corticosteroids.
Topics: Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchoconstrictor Agents; Cross-Over Studies; Double-Blind Method; Drug Tolerance; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Salmeterol Xinafoate | 1998 |
Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects.
Topics: Administration, Inhalation; Alanine; Area Under Curve; Arginine; Asthma; Breath Tests; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Nitric Oxide | 1998 |
[The anti-inflammatory action of an oral sustained-release theophylline preparation. Results of a clinical pilot study with low dosages].
Topics: Adult; Aged; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Delayed-Action Preparations; Eosinophils; Female; Humans; Male; Methacholine Chloride; Middle Aged; Pilot Projects; Respiratory Function Tests; Theophylline | 1998 |
Effects of skin cooling on airway reactivity in asthma.
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Female; Humans; Male; Methacholine Chloride; Reflex; Skin Temperature; Spirometry | 1998 |
Sensitivity of peak expiratory flow rate for diagnosing bronchial obstruction on methacholine inhalation challenge in school-aged asthmatic children.
Topics: Adolescent; Airway Obstruction; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Female; Humans; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Sensitivity and Specificity; Spirometry | 1998 |
Effect of chronic theophylline treatment on the methacholine dose-response curve in allergic asthmatic subjects.
Topics: Adult; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Forced Expiratory Volume; Humans; Long-Term Care; Male; Methacholine Chloride; Respiratory Hypersensitivity; Theophylline; Treatment Outcome | 1998 |
Influence of beclomethasone and salmeterol on the perception of methacholine-induced bronchoconstriction.
Topics: Administration, Inhalation; Adolescent; Adult; Albuterol; Asthma; Beclomethasone; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Female; Follow-Up Studies; Forced Expiratory Volume; Glucocorticoids; Humans; Male; Methacholine Chloride; Middle Aged; Perception; Salmeterol Xinafoate; Severity of Illness Index; Treatment Outcome | 1998 |
Potential masking effects of salmeterol on airway inflammation in asthma.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Anti-Asthmatic Agents; Asthma; Beclomethasone; Blood Proteins; Bronchial Provocation Tests; Bronchitis; Bronchoconstrictor Agents; Bronchodilator Agents; Budesonide; Cross-Over Studies; Disease Progression; Eosinophil Granule Proteins; Eosinophils; Female; Glucocorticoids; Humans; Inflammation Mediators; Leukocyte Count; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Placebos; Ribonucleases; Salmeterol Xinafoate; Spirometry; Sputum | 1998 |
Effect of exposure to low levels of ozone on the response to inhaled allergen in allergic asthmatic patients.
Topics: Administration, Inhalation; Adolescent; Adult; Air Pollutants; Allergens; Asthma; Bronchial Provocation Tests; Cross-Over Studies; Female; Forced Expiratory Volume; Humans; Hypersensitivity; Male; Methacholine Chloride; Middle Aged; Ozone; Prospective Studies; Single-Blind Method; Skin Tests; Vital Capacity | 1998 |
Exhaled nitric oxide and bronchial reactivity during and after inhaled beclomethasone in mild asthma.
Topics: Administration, Inhalation; Adult; Asthma; Beclomethasone; Breath Tests; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Over Studies; Female; Forced Expiratory Volume; Humans; Inflammation; Male; Methacholine Chloride; Nitric Oxide; Vital Capacity | 1998 |
Sputum eosinophilia is more closely associated with airway responsiveness to bradykinin than methacholine in asthma.
Topics: Adolescent; Adult; Analysis of Variance; Asthma; Bradykinin; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Eosinophilia; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Sensitivity and Specificity; Sputum | 1998 |
Comparison of 3 different doses of budesonide and placebo on the early asthmatic response to inhaled allergen.
Topics: Administration, Inhalation; Adult; Allergens; Anti-Inflammatory Agents; Asthma; Bronchoconstrictor Agents; Bronchodilator Agents; Budesonide; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride; Middle Aged; Placebos | 1998 |
Effect of angiotensin II receptor blockade on bronchial responsiveness in asthmatic subjects.
Topics: Administration, Oral; Adult; Angiotensin Receptor Antagonists; Antihypertensive Agents; Asthma; Bronchial Hyperreactivity; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Losartan; Male; Methacholine Chloride; Middle Aged; Placebos; Vital Capacity | 1998 |
Bronchial hyperresponsiveness, hypersensitivity to analgesics and urinary leukotriene E4 excretion in patients with aspirin-intolerant asthma.
Topics: Adult; Anti-Asthmatic Agents; Aspirin; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Chromatography, High Pressure Liquid; Cromolyn Sodium; Cross-Over Studies; Dipyrone; Double-Blind Method; Female; Humans; Leukotriene E4; Male; Methacholine Chloride; Middle Aged | 1998 |
Lack of interaction of hyperpnoea with methacholine and histamine in asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cold Temperature; Dose-Response Relationship, Drug; Drug Synergism; Exercise; Female; Forced Expiratory Volume; Histamine; Humans; Hyperventilation; Male; Methacholine Chloride | 1998 |
Severity of exercise-induced bronchoconstriction is related to airway eosinophilic inflammation in patients with asthma.
Topics: Adolescent; Adult; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Eosinophils; Exercise; Female; Humans; Inflammation; Male; Methacholine Chloride; Severity of Illness Index; Spirometry; Sputum; Statistics, Nonparametric | 1998 |
Clinical efficacy of low-dose inhaled budesonide once or twice daily in children with mild asthma not previously treated with steroids.
Topics: Administration, Inhalation; Adolescent; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Budesonide; Child; Double-Blind Method; Drug Administration Schedule; Exercise; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Pulmonary Ventilation | 1998 |
Effect of inhaled budesonide on lung function and airway inflammation. Assessment by various inflammatory markers in mild asthma.
Topics: Administration, Inhalation; Adult; Asthma; Bronchi; Bronchitis; Bronchoconstrictor Agents; Bronchodilator Agents; Budesonide; Cross-Over Studies; Double-Blind Method; Eosinophils; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Peak Expiratory Flow Rate | 1999 |
Protective effects of inhaled PGE2 on allergen-induced airway responses and airway inflammation.
Topics: Administration, Inhalation; Adult; Allergens; Asthma; Bronchoconstrictor Agents; Cell Count; Cross-Over Studies; Dinoprostone; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Sputum | 1999 |
A high dose of albuterol does not overcome bronchoprotective subsensitivity in asthmatic subjects receiving regular salmeterol or formoterol.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchodilator Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Ethanolamines; Female; Formoterol Fumarate; Humans; Male; Methacholine Chloride; Salmeterol Xinafoate; Single-Blind Method; Spirometry; Time Factors | 1999 |
A double-blind placebo-controlled study of the effect of influenza vaccination on airway responsiveness in asthma.
Topics: Adult; Aged; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Influenza A virus; Influenza Vaccines; Influenza, Human; Male; Methacholine Chloride; Middle Aged; Vaccination; Vaccines, Inactivated | 1998 |
Mild experimental exacerbation of asthma induced by individualised low-dose repeated allergen exposure. A double-blind evaluation.
Topics: Adult; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cats; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Methacholine Chloride; Middle Aged | 1998 |
Mechanism of mosaic attenuation of the lungs on computed tomography in induced bronchospasm.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Hypoxia; Lung; Male; Methacholine Chloride; Oxygen Consumption; Tomography, X-Ray Computed; Vasoconstriction | 1999 |
Beta2-adrenoceptor polymorphism and bronchoprotective sensitivity with regular short- and long-acting beta2-agonist therapy.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Asthma; Bronchoconstrictor Agents; Bronchodilator Agents; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Ethanolamines; Female; Formoterol Fumarate; Humans; Male; Methacholine Chloride; Middle Aged; Polymorphism, Genetic; Receptors, Adrenergic, beta-2; Terbutaline | 1999 |
Relationships between duration of asthma and asthma severity among children in the Childhood Asthma Management Program (CAMP)
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Albuterol; Allergens; Anti-Asthmatic Agents; Antigens, Dermatophagoides; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Canada; Child; Child, Preschool; Cohort Studies; Cross-Sectional Studies; Female; Forced Expiratory Volume; Glycoproteins; Housing; Humans; Hypersensitivity, Immediate; Linear Models; Male; Methacholine Chloride; Multivariate Analysis; Severity of Illness Index; Skin Tests; Time Factors; Treatment Outcome; United States; Vital Capacity | 1999 |
Sustained bronchoprotection, bronchodilatation, and symptom control during regular formoterol use in asthma of moderate or greater severity. The Canadian FO/OD1 Study Group.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Albuterol; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchodilator Agents; Double-Blind Method; Ethanolamines; Female; Forced Expiratory Volume; Formoterol Fumarate; Humans; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Safety; Severity of Illness Index; Treatment Outcome | 1999 |
Levodropropizine (LD) activity in allergic asthmatic patients, challenged with ultrasonically nebulized distilled water, metacholine and allergen-induced bronchospasm.
Topics: Administration, Oral; Adolescent; Adult; Allergens; Antitussive Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchial Spasm; Cross-Over Studies; Double-Blind Method; Female; Humans; Hypersensitivity; Male; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers; Placebos; Propylene Glycols; Ultrasonic Therapy; Water | 1994 |
Effect of the leukotriene receptor antagonist pranlukast on cellular infiltration in the bronchial mucosa of patients with asthma.
Topics: Adrenergic beta-Agonists; Adult; Anti-Asthmatic Agents; Antigens, CD; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoconstrictor Agents; Chromones; Double-Blind Method; Eosinophils; Female; Forced Expiratory Volume; Humans; Leukotriene Antagonists; Male; Mast Cells; Methacholine Chloride; Mucous Membrane; Statistics, Nonparametric; T-Lymphocytes | 1998 |
Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group.
Topics: Administration, Inhalation; Administration, Topical; Adult; Anti-Inflammatory Agents; Asthma; Biopsy; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Female; Forced Expiratory Volume; Glucocorticoids; Humans; Inflammation; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Practice Guidelines as Topic; Prospective Studies; Single-Blind Method; Steroids | 1999 |
A comparison of the onset of action of salbutamol and formoterol in reversing methacholine-induced bronchoconstriction.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Airway Resistance; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Double-Blind Method; Ethanolamines; Female; Formoterol Fumarate; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests; Time Factors | 1998 |
Effect of single doses of inhaled lignocaine on FEV1 and bronchial reactivity in asthma.
Topics: Administration, Inhalation; Adult; Albuterol; Anesthetics, Local; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Forced Expiratory Volume; Humans; Lidocaine; Male; Methacholine Chloride; Middle Aged | 1998 |
Effect of inhaled leukotriene D4 on airway eosinophilia and airway hyperresponsiveness in asthmatic subjects.
Topics: Administration, Inhalation; Adult; Allergens; Asthma; Bronchoconstrictor Agents; Cross-Over Studies; Double-Blind Method; Eosinophilia; Female; Forced Expiratory Volume; Humans; Leukotriene D4; Male; Methacholine Chloride; Respiratory Hypersensitivity; Respiratory System; Spirometry; Sputum | 1999 |
Salbutamol pretreatment does not change eosinophil percentage and eosinophilic cationic protein concentration in hypertonic saline-induced sputum in asthmatic subjects.
Topics: Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Blood Proteins; Bronchial Provocation Tests; Bronchodilator Agents; Eosinophils; Histamine; Humans; Methacholine Chloride; Saline Solution, Hypertonic; Single-Blind Method; Specimen Handling; Sputum | 1999 |
Diagnosing occupational asthma: use of induced sputum.
Topics: Adult; Asthma; Biomarkers; Blood Proteins; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cross-Over Studies; Eosinophil Granule Proteins; Eosinophils; Female; Humans; Inflammation Mediators; Leukocyte Count; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Prospective Studies; Reference Values; Respiratory Function Tests; Ribonucleases; Sensitivity and Specificity; Software; Sputum | 1999 |
House dust mite avoidance for children with asthma in homes of low-income families.
Topics: Adolescent; Air Pollution, Indoor; Allergens; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Antigens; Asthma; Beclomethasone; Bronchial Hyperreactivity; Child; Cromolyn Sodium; Dust; Environmental Pollutants; Glycoproteins; Humans; Methacholine Chloride; Mites; Respiratory Function Tests; Socioeconomic Factors; Triamcinolone | 1999 |
Protection against methacholine bronchoconstriction to assess relative potency of inhaled beta2-agonist.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Therapeutic Equivalency; Vital Capacity | 1999 |
Comparison of formoterol, salbutamol and salmeterol in methacholine-induced severe bronchoconstriction.
Topics: Administration, Inhalation; Adult; Albuterol; Asthma; Bronchoconstriction; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Ethanolamines; Female; Formoterol Fumarate; Humans; Male; Methacholine Chloride; Salmeterol Xinafoate; Time Factors | 1999 |
Airway inflammation in asthma and chronic obstructive pulmonary disease with special emphasis on the antigen-presenting dendritic cell: influence of treatment with fluticasone propionate.
Topics: Androstadienes; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dendritic Cells; Dose-Response Relationship, Drug; Fluticasone; Forced Expiratory Volume; Humans; Lung Diseases, Obstructive; Methacholine Chloride | 1999 |
Effect of different inhaled bronchodilators on recovery from methacholine-induced bronchoconstriction in asthmatic children.
Topics: Administration, Inhalation; Adolescent; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Child; Child, Preschool; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Nebulizers and Vaporizers | 1999 |
Airway responsiveness to methacholine: effects of deep inhalations and airway inflammation.
Topics: Administration, Inhalation; Adolescent; Adult; Airway Resistance; Asthma; Bronchoconstrictor Agents; Cell Count; Dose-Response Relationship, Drug; Eosinophils; Female; Forced Expiratory Volume; Humans; Inflammation; Lung Volume Measurements; Male; Methacholine Chloride; Middle Aged; Plethysmography; Residual Volume; Respiration; Sputum | 1999 |
Maximal response plateau to methacholine as a reliable index for reducing inhaled budesonide in moderate asthma.
Topics: Administration, Inhalation; Adolescent; Adult; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Budesonide; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate | 1999 |
Bronchoprotective and bronchodilator effects of single doses of (S)-salbutamol, (R)-salbutamol and racemic salbutamol in patients with bronchial asthma.
Topics: Adenosine Monophosphate; Adult; Albuterol; Asthma; Bronchi; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Drug Hypersensitivity; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Spirometry; Stereoisomerism; Time Factors | 1999 |
Fluticasone propionate and bronchial hyperresponsiveness in childhood asthma.
Topics: Administration, Inhalation; Adolescent; Androstadienes; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Female; Fluticasone; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Treatment Outcome | 1999 |
Risk of asthma in the general Spanish population attributable to specific immunoresponse. Spanish Group of the European Community Respiratory Health Survey.
Topics: Adult; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Sectional Studies; Diagnosis, Differential; Female; Humans; Hypersensitivity, Immediate; Immunocompetence; Immunoglobulin E; Male; Methacholine Chloride; Prevalence; Skin Tests; Smoking; Spain; Surveys and Questionnaires | 1999 |
[Endothelin concentration in sera of patients with atopic bronchial asthma].
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Endothelin-1; Humans; Methacholine Chloride; Muscle, Smooth | 1999 |
Increased airway responsiveness to acetaldehyde in asthmatic subjects with alcohol-induced bronchoconstriction.
Topics: Acetaldehyde; Administration, Inhalation; Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cross-Over Studies; Diagnosis, Differential; Double-Blind Method; Drug Hypersensitivity; Ethanol; Female; Humans; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests | 1999 |
Effect of long-term salmeterol therapy compared with as-needed albuterol use on airway hyperresponsiveness.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Aerosols; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Double-Blind Method; Drug Administration Schedule; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Salmeterol Xinafoate | 1999 |
Dose versus concentration of methacholine.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Forced Expiratory Volume; Humans; Methacholine Chloride | 1999 |
Therapeutic equivalence of Spiros dry powder inhaler and Ventolin metered dose inhaler. A bioassay using methacholine.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Child; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers; Powders; Therapeutic Equivalency | 1999 |
Sputum cellular and cytokine responses to inhaled endothelin-1 in asthma.
Topics: Adult; Albumins; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cell Count; Cross-Over Studies; Cytokines; Double-Blind Method; Endothelin-1; Female; Humans; Interleukin-1; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Sputum; Tumor Necrosis Factor-alpha | 1999 |
Latanoprost and respiratory function in asthmatic patients: randomized, double-masked, placebo-controlled crossover evaluation.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Albuterol; Asthma; Bronchial Provocation Tests; Cross-Over Studies; Double-Blind Method; Female; Humans; Intraocular Pressure; Latanoprost; Lung; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Prostaglandins F, Synthetic; Respiratory Physiological Phenomena; Spirometry | 1999 |
Allergen-induced synthesis of F(2)-isoprostanes in atopic asthmatics. Evidence for oxidant stress.
Topics: Administration, Inhalation; Adult; Allergens; Asthma; Beclomethasone; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Forced Expiratory Volume; Glucocorticoids; Humans; Hypersensitivity, Immediate; Mass Spectrometry; Methacholine Chloride; Middle Aged; Oxidative Stress; Prostaglandins F; Reactive Oxygen Species; Skin Tests | 1999 |
Variability in lung deposition of inhaled drug, within and between asthmatic patients, with a pMDI and a dry powder inhaler, Turbuhaler.
Topics: Administration, Inhalation; Adult; Anti-Asthmatic Agents; Asthma; Bronchi; Bronchoconstrictor Agents; Bronchodilator Agents; Female; Histamine; Histamine Antagonists; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers; Powders; Terbutaline | 2000 |
Airway responsiveness to acetaldehyde in patients with asthma: relationship to methacholine responsiveness and peak expiratory flow variation.
Topics: Acetaldehyde; Adult; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Single-Blind Method | 2000 |
Ozone-induced inflammation assessed in sputum and bronchial lavage fluid from asthmatics: a new noninvasive tool in epidemiologic studies on air pollution and asthma.
Topics: Adult; Asthma; Biomarkers; Blood Proteins; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Eosinophil Granule Proteins; Eosinophils; Female; Humans; Inflammation; Interleukin-8; Leukocyte Count; Leukocyte Elastase; Male; Methacholine Chloride; Ozone; Placebos; Ribonucleases; Sputum | 1999 |
Comparison of two standardized methods of methacholine inhalation challenge in young adults.
Topics: Administration, Inhalation; Adult; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Reference Values | 2000 |
Effects of inhaled steroids on methacholine-induced bronchoconstriction and gas trapping in mild asthma.
Topics: Administration, Inhalation; Adult; Analysis of Variance; Androstadienes; Anti-Inflammatory Agents; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Chi-Square Distribution; Double-Blind Method; Drug Administration Schedule; Female; Fluticasone; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Probability; Pulmonary Gas Exchange; Reference Values; Sensitivity and Specificity; Treatment Outcome | 2000 |
Effects of terbutaline and budesonide on sputum cells and bronchial hyperresponsiveness in asthma.
Topics: Administration, Topical; Adolescent; Adrenergic beta-Agonists; Adult; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Budesonide; Cell Count; Cross-Over Studies; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Forced Expiratory Volume; Glucocorticoids; Humans; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Sodium Chloride; Sputum; Terbutaline | 2000 |
The protective effect of salbutamol inhaled using different devices on methacholine bronchoconstriction.
Topics: Adolescent; Adult; Aged; Airway Resistance; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Equipment Design; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers | 2000 |
Dose-responses over time to inhaled fluticasone propionate treatment of exercise- and methacholine-induced bronchoconstriction in children with asthma.
Topics: Administration, Inhalation; Adolescent; Androstadienes; Anti-Asthmatic Agents; Asthma; Asthma, Exercise-Induced; Bronchoconstriction; Child; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fluticasone; Humans; Male; Methacholine Chloride | 2000 |
Effect of pranlukast on bronchial inflammation in patients with asthma.
Topics: Adult; Anti-Asthmatic Agents; Asthma; Blood Proteins; Bronchial Provocation Tests; Bronchoconstriction; Chromones; Cross-Over Studies; Double-Blind Method; Eosinophil Granule Proteins; Eosinophils; Female; Humans; Leukocyte Count; Male; Methacholine Chloride; Middle Aged; Ribonucleases; Sputum | 2000 |
Comparison of allergen-induced changes in bronchial hyperresponsiveness and airway inflammation between mildly allergic asthma patients and allergic rhinitis patients.
Topics: Adult; Antigens, Dermatophagoides; Asthma; Blood Proteins; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cell Count; Chymases; Eosinophil Granule Proteins; Eosinophils; Female; Forced Expiratory Volume; Glycoproteins; Humans; Interleukin-5; Male; Methacholine Chloride; Pulmonary Eosinophilia; Rhinitis, Allergic, Perennial; Ribonucleases; Serine Endopeptidases; Serum Albumin; Sputum; Tryptases | 2000 |
Comparison of the effect on bronchial hyperresponsiveness of beclomethasone dipropionate administered via a novel multidose dry-powder inhaler or a conventional pressurised metered dose inhaler.
Topics: Administration, Inhalation; Adult; Analysis of Variance; Asthma; Beclomethasone; Bronchial Hyperreactivity; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Equipment Design; Female; Follow-Up Studies; Humans; Male; Methacholine Chloride; Nebulizers and Vaporizers; Respiratory Function Tests; Statistics, Nonparametric | 2000 |
Clarithromycin suppresses bronchial hyperresponsiveness associated with eosinophilic inflammation in patients with asthma.
Topics: Adult; Asthma; Blood Proteins; Bronchial Hyperreactivity; Bronchial Provocation Tests; Clarithromycin; Cross-Over Studies; Eosinophil Granule Proteins; Eosinophilia; Female; Forced Expiratory Volume; Humans; Inflammation; Inflammation Mediators; Male; Methacholine Chloride; Middle Aged; Ribonucleases; Sputum | 2000 |
Effect of losartan, a type 1 angiotensin II receptor antagonist, on bronchial hyperresponsiveness to methacholine in patients with bronchial asthma.
Topics: Adult; Aged; Angiotensin Receptor Antagonists; Asthma; Bronchi; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Losartan; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2 | 2000 |
Potent bronchoprotective effect of deep inspiration and its absence in asthma.
Topics: Adult; Aerosols; Allergens; Asthma; Bronchi; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Reference Values; Reproducibility of Results; Respiratory Function Tests; Respiratory Mechanics; Vital Capacity | 2000 |
Bronchial responsiveness to methacholine is increased in citrus red mite (Panonychus citri)-sensitive children without asthmatic symptoms.
Topics: Adolescent; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Citrus; Dose-Response Relationship, Immunologic; Female; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride; Rhinitis; Risk Factors; Skin Tests; Trombiculidae | 2000 |
[Effect of output from jet nebulizers on PC20 values in asthmatic children].
Topics: Adolescent; Asthma; Child; Cross-Over Studies; Equipment Design; Forced Expiratory Volume; Humans; Methacholine Chloride; Nebulizers and Vaporizers; Single-Blind Method | 2000 |
Functional antagonism with formoterol and salmeterol in asthmatic patients expressing the homozygous glycine-16 beta(2)-adrenoceptor polymorphism.
Topics: Administration, Inhalation; Adolescent; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Adult; Aged; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cross-Over Studies; Double-Blind Method; Ethanolamines; Female; Formoterol Fumarate; Glycine; Humans; Male; Methacholine Chloride; Middle Aged; Polymorphism, Genetic; Receptors, Adrenergic, beta-2; Salmeterol Xinafoate; Treatment Outcome | 2000 |
Low-dose inhaled budesonide once or twice daily for 27 months in children with mild asthma.
Topics: Administration, Inhalation; Adolescent; Anti-Inflammatory Agents; Asthma; Blood Proteins; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Budesonide; Child; Double-Blind Method; Drug Administration Schedule; Eosinophil Granule Proteins; Eosinophils; Exercise Test; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Patient Compliance; Placebos; Pulmonary Eosinophilia; Ribonucleases | 2000 |
Exercise, methacholine, and adenosine 5'-monophosphate challenges in children with asthma: relation to severity of the disease.
Topics: Adenosine Monophosphate; Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Exercise Test; Female; Humans; Male; Methacholine Chloride; Sensitivity and Specificity; Severity of Illness Index | 2000 |
A role for the C3a anaphylatoxin receptor in the effector phase of asthma.
Topics: Animals; Antigens, CD; Asthma; Complement C3a; Disease Models, Animal; Female; Humans; Hypersensitivity, Immediate; Lung; Male; Membrane Proteins; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Plethysmography; Receptor, Anaphylatoxin C5a; Receptors, Complement | 2000 |
[Analysis of bronchial hypersensitivity in patients with bronchial asthma].
Topics: Administration, Inhalation; Adolescent; Adult; Aged; Airway Resistance; Androstadienes; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Fluticasone; Humans; Male; Methacholine Chloride; Middle Aged; Regression Analysis; Severity of Illness Index | 2000 |
The effect of inhaled budesonide on symptoms, lung function, and cold air and methacholine responsiveness in 2- to 5-year-old asthmatic children.
Topics: Administration, Inhalation; Airway Resistance; Asthma; Bronchial Provocation Tests; Budesonide; Child, Preschool; Cold Temperature; Double-Blind Method; Female; Humans; Male; Methacholine Chloride | 2000 |
Bronchial hyperresponsiveness before and after the diagnosis of bronchial asthma in children.
Topics: Asthma; Child, Preschool; Female; Humans; Male; Methacholine Chloride; Respiratory Hypersensitivity | 2000 |
Effects of esophageal acid perfusion on airway hyperresponsiveness in patients with bronchial asthma.
Topics: Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Esophagus; Female; Forced Expiratory Volume; Gastroesophageal Reflux; Humans; Hydrochloric Acid; Hydrogen-Ion Concentration; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Vital Capacity | 2000 |
Inhaled mannitol shifts exhaled nitric oxide in opposite directions in asthmatics and healthy subjects.
Topics: Administration, Inhalation; Adult; Asthma; Female; Forced Expiratory Volume; Humans; Male; Mannitol; Methacholine Chloride; Nitric Oxide; Osmolar Concentration; Pulmonary Alveoli; Respiratory Function Tests | 2001 |
Effect of cetirizine on bronchial hyperresponsiveness in patients with seasonal allergic rhinitis and asthma.
Topics: Adult; Anti-Allergic Agents; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cetirizine; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 Antagonists; Humans; Male; Methacholine Chloride; Nasal Provocation Tests; Respiratory Function Tests; Rhinitis, Allergic, Seasonal | 2001 |
Regular inhaled salbutamol : effect on airway responsiveness to methacholine and adenosine 5'-monophosphate and tolerance to bronchoprotection.
Topics: Adenosine Monophosphate; Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Double-Blind Method; Humans; Methacholine Chloride | 2001 |
Bronchial hyperresponsiveness and exhaled nitric oxide in patients with cardiac disease.
Topics: Adult; Aged; Analysis of Variance; Angina Pectoris; Asthma; Bronchial Hyperreactivity; Cardiovascular Diseases; Female; Heart Failure; Humans; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Probability; Respiratory Function Tests; Sensitivity and Specificity; Statistics, Nonparametric | 2001 |
High-resolution computed tomographic evaluation of airway distensibility and the effects of lung inflation on airway caliber in healthy subjects and individuals with asthma.
Topics: Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Female; Humans; Lung; Lung Volume Measurements; Male; Methacholine Chloride; Probability; Pulmonary Alveoli; Reference Values; Respiratory Function Tests; Respiratory Mechanics; Tomography, X-Ray Computed | 2001 |
Three years of specific immunotherapy with house-dust-mite extracts in patients with rhinitis and asthma: significant improvement of allergen-specific parameters and of nonspecific bronchial hyperreactivity.
Topics: Adult; Animals; Asthma; Bronchial Hyperreactivity; Desensitization, Immunologic; Double-Blind Method; Dust; Female; Follow-Up Studies; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Male; Methacholine Chloride; Middle Aged; Mites; Rhinitis | 2001 |
Eosinophil markers in blood, serum, and urine for monitoring the clinical course in childhood asthma: impact of budesonide treatment and withdrawal.
Topics: Adolescent; Anti-Asthmatic Agents; Antigens, CD; Asthma; Biomarkers; Blood Proteins; Bronchial Hyperreactivity; Bronchial Provocation Tests; Budesonide; Child; Disease Progression; Double-Blind Method; Eosinophil Granule Proteins; Eosinophil Peroxidase; Eosinophil-Derived Neurotoxin; Eosinophils; Female; Forced Expiratory Volume; Humans; Inflammation; Leukocyte Count; Male; Membrane Glycoproteins; Methacholine Chloride; Peroxidase; Peroxidases; Ribonucleases; Skin Tests; Spirometry; Tetraspanin 29 | 2001 |
Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study.
Topics: Aged; Asthma; Biomarkers; Blood Proteins; Bronchial Provocation Tests; Bronchoconstrictor Agents; Eosinophil Granule Proteins; Eosinophils; Female; Forced Expiratory Volume; Humans; Inflammation; Leukocyte Count; Male; Methacholine Chloride; Predictive Value of Tests; Ribonucleases; Serine Endopeptidases; Severity of Illness Index; Sputum; Tryptases | 2001 |
Pulmonary gas exchange responses to histamine and methacholine challenges in mild asthma.
Topics: Adult; Airway Resistance; Asthma; Blood Gas Analysis; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Oxygen; Partial Pressure; Pulmonary Gas Exchange; Ventilation-Perfusion Ratio | 2001 |
PC(20) adenosine 5'-monophosphate is more closely associated with airway inflammation in asthma than PC(20) methacholine.
Topics: Adenosine Monophosphate; Adolescent; Adult; Asthma; Breath Tests; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Eosinophils; Female; Forced Expiratory Volume; Humans; Inflammation; Linear Models; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Predictive Value of Tests; Sputum | 2001 |
Decreased bronchodilating effect of salbutamol in relieving methacholine induced moderate to severe bronchoconstriction during high dose treatment with long acting beta2 agonists.
Topics: Administration, Inhalation; Adolescent; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Cross-Over Studies; Data Interpretation, Statistical; Double-Blind Method; Drug Tolerance; Ethanolamines; Forced Expiratory Volume; Formoterol Fumarate; Humans; Methacholine Chloride; Middle Aged; Salmeterol Xinafoate | 2001 |
Effects of candesartan on cough and bronchial hyperresponsiveness in mildly to moderately hypertensive patients with symptomatic asthma.
Topics: Adult; Aged; Antihypertensive Agents; Asthma; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Bronchial Hyperreactivity; Calcium Channel Blockers; Cough; Dihydropyridines; Female; Genetic Testing; Humans; Hypertension; Incidence; Male; Methacholine Chloride; Middle Aged; Nifedipine; Nitrobenzenes; Pain Measurement; Peptidyl-Dipeptidase A; Piperazines; Polymorphism, Genetic; Respiratory Function Tests; Tetrazoles; Treatment Outcome | 2001 |
Airway narrowing associated with inhibition of deep inspiration during methacholine inhalation in asthmatics.
Topics: Administration, Inhalation; Adult; Asthma; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Respiration | 2001 |
Dose-dependent effects of inhaled mometasone furoate on airway function and inflammation after allergen inhalation challenge.
Topics: Administration, Inhalation; Adolescent; Adult; Airway Resistance; Allergens; Anti-Inflammatory Agents; Asthma; Bronchoconstrictor Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Eosinophils; Female; Forced Expiratory Volume; Humans; Inflammation; Male; Methacholine Chloride; Middle Aged; Mometasone Furoate; Pregnadienediols; Severity of Illness Index; Sputum; Time Factors; Treatment Outcome | 2001 |
Regional expiratory flow limitation studied with Technegas in asthma.
Topics: Adult; Asthma; Bronchi; Bronchoconstriction; Bronchoconstrictor Agents; Diagnostic Imaging; Humans; Lung Volume Measurements; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Respiratory Function Tests; Respiratory Mechanics; Sodium Pertechnetate Tc 99m; Spirometry; Tomography, Emission-Computed, Single-Photon | 2001 |
Corticosteroid-induced improvement in the PC20 of adenosine monophosphate is more closely associated with reduction in airway inflammation than improvement in the PC20 of methacholine.
Topics: Adenosine Monophosphate; Adult; Androstadienes; Anti-Inflammatory Agents; Asthma; Female; Fluticasone; Forced Expiratory Volume; Glucocorticoids; Humans; Inflammation; Male; Methacholine Chloride; Multivariate Analysis; Prednisone | 2001 |
Low-dose theophylline does not exert its anti-inflammatory effects in mild asthma through upregulation of interleukin-10 in alveolar macrophages.
Topics: Adult; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Forced Expiratory Volume; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-10; Macrophages, Alveolar; Male; Methacholine Chloride; Severity of Illness Index; Theophylline; Treatment Outcome; Tumor Necrosis Factor-alpha; Up-Regulation | 2001 |
Comparison of airway conductance and FEV(1) as measures of airway responsiveness to methacholine. Discrimination of small differences in bronchial responsiveness with Gaw and FEV(1).
Topics: Adolescent; Adult; Aged; Air Pollution, Indoor; Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Dose-Response Relationship, Drug; Dust; Female; Forced Expiratory Volume; Housing, Animal; Humans; Male; Methacholine Chloride; Middle Aged; Models, Theoretical; Occupational Exposure; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Swine | 2001 |
Effect of apocynin on ozone-induced airway hyperresponsiveness to methacholine in asthmatics.
Topics: Acetophenones; Administration, Inhalation; Adult; Aerosols; Antioxidants; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; NADPH Oxidases; Ozone; Placebos | 2001 |
One-year treatment with different dosing schedules of fluticasone propionate in childhood asthma. Effects on hyperresponsiveness, lung function, and height.
Topics: Administration, Inhalation; Androstadienes; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Body Height; Breath Tests; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Chronic Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Fluticasone; Forced Expiratory Volume; Humans; Methacholine Chloride; Nitric Oxide; Time Factors | 2001 |
Therapeutic equivalence of three metered-dose inhalers containing salbutamol (Albuterol) in protecting against methacholine-induced bronchoconstriction in children with asthma.
Topics: Adolescent; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Child; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Nebulizers and Vaporizers; Particle Size; Spirometry; Therapeutic Equivalency | 2001 |
In search of childhood asthma: questionnaire, tests of bronchial hyperresponsiveness, and clinical evaluation.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Diagnosis, Differential; Exercise Test; Humans; Methacholine Chloride; Sensitivity and Specificity; Spirometry; Surveys and Questionnaires | 2002 |
Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study).
Topics: Adolescent; Asthma; Betula; Bronchial Provocation Tests; Child; Conjunctivitis, Allergic; Desensitization, Immunologic; Humans; Methacholine Chloride; Poaceae; Pollen; Rhinitis, Allergic, Seasonal; Seasons | 2002 |
Significant variability in response to inhaled corticosteroids for persistent asthma.
Topics: Administration, Inhalation; Adolescent; Adult; Androstadienes; Anti-Asthmatic Agents; Asthma; Beclomethasone; Chronic Disease; Female; Fluticasone; Forced Expiratory Volume; Humans; Hydrocortisone; Male; Methacholine Chloride; Middle Aged; Prospective Studies; Treatment Outcome | 2002 |
The relation between adrenal function and the severity of bronchial hyperresponsiveness in children as measured by the methacholine provocation test.
Topics: Adolescent; Adrenal Cortex Function Tests; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Chronic Disease; Female; Humans; Hydrocortisone; Male; Methacholine Chloride | 2002 |
[The effect of inhaled heparin on airway responsiveness to metacholine in asthmatic children].
Topics: Administration, Inhalation; Adolescent; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Cross-Over Studies; Double-Blind Method; Female; Heparin; Humans; Male; Methacholine Chloride; Time Factors; Treatment Outcome | 2001 |
Short-term acupuncture therapy is of no benefit in patients with moderate persistent asthma.
Topics: Acupuncture; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Double-Blind Method; Forced Expiratory Volume; Humans; Methacholine Chloride; Peak Expiratory Flow Rate; Spirometry; Treatment Outcome | 2002 |
Decreased peroxynitrite inhibitory activity in induced sputum in patients with bronchial asthma.
Topics: Adult; Asthma; Blood Proteins; Bronchi; Bronchial Provocation Tests; Eosinophil Granule Proteins; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Peroxynitrous Acid; Ribonucleases; Sputum | 2002 |
Contrasting effects of allergen challenge on airway responsiveness to cysteinyl leukotriene D(4) and methacholine in mild asthma.
Topics: Administration, Inhalation; Adult; Allergens; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Humans; Leukotriene D4; Male; Methacholine Chloride; Reproducibility of Results; Sensitivity and Specificity | 2002 |
[Effects of inhaled aerosol of platelet activating factor on pulmonary function and airway responsiveness in normal subjects].
Topics: Adult; Aerosols; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Chlorpheniramine; Double-Blind Method; Humans; Lung; Male; Methacholine Chloride; Platelet Activating Factor; Respiratory Function Tests | 1992 |
The effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responses to neurokinin A in normal humans in vivo.
Topics: Adult; Aerosols; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Double-Blind Method; Humans; Male; Methacholine Chloride; Neprilysin; Neurokinin A; Premedication; Thiorphan; Time Factors | 1992 |
The long-term effect of nedocromil sodium on the maximal degree of airway narrowing to methacholine in atopic asthmatic subjects.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchoconstriction; Double-Blind Method; Drug Resistance; Female; Humans; Male; Methacholine Chloride; Nedocromil; Quinolones; Respiratory Function Tests; Time Factors | 1992 |
The effect of repirinast on airway responsiveness to methacholine and allergen.
Topics: Adolescent; Adult; Allergens; Asthma; Bronchi; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Quinolones | 1992 |
Effect of indomethacin on leukotriene4-induced histamine hyperresponsiveness in asthmatic subjects.
Topics: Adult; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Histamine; Humans; Indomethacin; Leukotriene E4; Male; Methacholine Chloride; SRS-A | 1992 |
Betel-nut chewing and asthma.
Topics: Adult; Animals; Areca; Arecoline; Asthma; Bangladesh; Bronchial Provocation Tests; Bronchoconstriction; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Guinea Pigs; Hospitals, Special; Humans; London; Male; Methacholine Chloride; Middle Aged; Plants, Medicinal; Risk Factors | 1992 |
Effect of azelastine on the seasonal increase in non-specific bronchial responsiveness to methacholine in pollen allergic patients. A randomized, double-blind placebo-controlled, crossover study.
Topics: Administration, Oral; Adolescent; Adult; Allergens; Asthma; Bronchial Hyperreactivity; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 Antagonists; Humans; Immunization; Male; Methacholine Chloride; Phthalazines; Pollen; Rhinitis, Allergic, Seasonal; Skin Tests | 1992 |
Long-term effects of a long-acting beta 2-adrenoceptor agonist, salmeterol, on airway hyperresponsiveness in patients with mild asthma.
Topics: Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchodilator Agents; Double-Blind Method; Drug Tolerance; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Salmeterol Xinafoate | 1992 |
Tolerance to the nonbronchodilator effects of inhaled beta 2-agonists in asthma.
Topics: Adenosine Monophosphate; Administration, Inhalation; Adrenergic beta-Agonists; Adult; Asthma; Bronchi; Double-Blind Method; Drug Tolerance; Female; Humans; Male; Methacholine Chloride; Middle Aged; Terbutaline | 1992 |
Airway calibre as a confounder in interpreting bronchial responsiveness in asthma.
Topics: Adrenal Cortex Hormones; Adult; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Histamine H1 Antagonists; Humans; Male; Methacholine Chloride; Middle Aged | 1992 |
The protective effect of low-dose inhaled fenoterol against methacholine and exercise-induced bronchoconstriction in asthma: a dose-response study.
Topics: Adolescent; Adult; Aerosols; Asthma; Asthma, Exercise-Induced; Bronchoconstriction; Dose-Response Relationship, Drug; Female; Fenoterol; Humans; Male; Methacholine Chloride | 1992 |
The effect of GR32191 (a thromboxane receptor antagonist) on airway responsiveness in asthma.
Topics: Adult; Asthma; Biphenyl Compounds; Bronchial Hyperreactivity; Double-Blind Method; Female; Forced Expiratory Volume; Heptanoic Acids; Humans; Male; Methacholine Chloride; Middle Aged; Receptors, Thromboxane; Thromboxane A2 | 1992 |
Effect of inhaled platelet-activating factor on bronchial inflammation in atopic non-asthmatic subjects.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Cell Degranulation; Double-Blind Method; Eosinophils; Female; Humans; Male; Mast Cells; Methacholine Chloride; Placebos; Platelet Activating Factor | 1992 |
Modification of histamine- and methacholine-induced bronchoconstriction by calcium antagonist gallopamil in asthmatics.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Dose-Response Relationship, Drug; Drug Interactions; Female; Gallopamil; Histamine; Humans; Least-Squares Analysis; Male; Methacholine Chloride; Respiratory Function Tests | 1992 |
A trial of nebulized magnesium sulfate to reverse bronchospasm in asthmatic patients.
Topics: Adult; Asthma; Bronchial Spasm; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Magnesium Sulfate; Male; Methacholine Chloride; Nebulizers and Vaporizers | 1992 |
Effect of allergen inhalation on the maximal response plateau of the dose-response curve to methacholine.
Topics: Administration, Inhalation; Allergens; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Dose-Response Relationship, Immunologic; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Methacholine Chloride; Rhinitis; Single-Blind Method; Skin Tests; Time Factors | 1992 |
Greater effect of inhaled budesonide on adenosine 5'-monophosphate-induced than on sodium-metabisulfite-induced bronchoconstriction in asthma.
Topics: Adenosine Monophosphate; Administration, Inhalation; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchodilator Agents; Budesonide; Double-Blind Method; Drug Evaluation; Forced Expiratory Volume; Glucocorticoids; Humans; Methacholine Chloride; Pregnenediones; Sulfites | 1992 |
Changes in cross-sectional airway areas induced by methacholine, histamine, and LTC4 in asthmatic subjects.
Topics: Analysis of Variance; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Histamine; Humans; Methacholine Chloride; Respiratory Function Tests; Sound; SRS-A | 1992 |
Effect of inhaled ipratropium bromide on the airway response to methacholine, histamine, and exercise in patients with mild bronchial asthma.
Topics: Adult; Aerosols; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Exercise; Female; Histamine; Humans; Ipratropium; Male; Methacholine Chloride | 1992 |
Protective effects of inhaled ipratropium bromide on bronchoconstriction induced by adenosine and methacholine in asthma.
Topics: Adenosine; Administration, Inhalation; Adolescent; Adult; Asthma; Bronchoconstriction; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Ipratropium; Male; Methacholine Chloride; Middle Aged; Reflex; Vagus Nerve | 1992 |
Stability of the circadian alteration in lung function in asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Circadian Rhythm; Forced Expiratory Volume; Humans; Lung; Methacholine Chloride; Peak Expiratory Flow Rate; Theophylline; Time Factors | 1992 |
Comparison of bronchial reactivity and peak expiratory flow variability measurements for epidemiologic studies.
Topics: Adolescent; Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; England; Humans; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Rural Population; Skin Tests; Surveys and Questionnaires | 1992 |
Angiotensin-converting enzyme inhibitors in patients with bronchial responsiveness and asthma.
Topics: Adolescent; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cough; Double-Blind Method; Drug Tolerance; Enalapril; Female; Humans; Male; Methacholine Chloride; Middle Aged; Prospective Studies; Single-Blind Method | 1992 |
Single-dose effect of astemizole on bronchoconstriction induced by histamine in asthmatic subjects.
Topics: Adult; Aged; Astemizole; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Double-Blind Method; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Middle Aged; Skin Tests; Vital Capacity | 1992 |
[The nonspecific bronchial stimulation test with methacholine and an ultrasonic mist of distilled water: which is to be preferred in the military sphere?].
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Evaluation Studies as Topic; Humans; Italy; Methacholine Chloride; Military Personnel; Skin Tests; Water | 1992 |
Leukotrienes C4, D4, and E4 enhance histamine responsiveness in asthmatic airways.
Topics: Airway Resistance; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Histamine; Humans; Leukotriene E4; Methacholine Chloride; SRS-A; Time Factors | 1991 |
Lack of effect of 4 weeks of oral H1 antagonist on bronchial responsiveness.
Topics: Administration, Oral; Adult; Asthma; Bronchoconstriction; Chronic Disease; Double-Blind Method; Drug Evaluation; Female; Forced Expiratory Volume; Histamine H1 Antagonists; Humans; Male; Methacholine Chloride; Middle Aged; Terfenadine | 1991 |
Combined effect of nifedipine and diltiazem on methacholine-induced bronchoconstriction in asthmatic patients.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Diltiazem; Drug Therapy, Combination; Female; Humans; Male; Methacholine Chloride; Nifedipine; Spirometry | 1992 |
Changes in bronchial responsiveness following nasal provocation with allergen.
Topics: Adolescent; Adult; Allergens; Analysis of Variance; Asthma; Bronchial Hyperreactivity; Double-Blind Method; Female; Humans; Male; Methacholine Chloride; Nasal Provocation Tests; Respiratory Function Tests; Rhinitis, Allergic, Seasonal; Time Factors | 1992 |
Asthmatic responses to passive cigarette smoke: persistence of reactivity and effect of medications.
Topics: Adult; Albuterol; Asthma; Bronchial Provocation Tests; Cromolyn Sodium; Female; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests; Respiratory Hypersensitivity; Skin Tests; Tobacco Smoke Pollution | 1991 |
[The effect of an oral gold compound, auranofin, on bronchial responsiveness to inhaled methacholine in well-controlled bronchial asthma].
Topics: Adult; Aged; Asthma; Auranofin; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Double-Blind Method; Female; Humans; Male; Methacholine Chloride; Middle Aged | 1991 |
Effect of a thromboxane A2 receptor antagonist (AA-2414) on bronchial hyperresponsiveness to methacholine in subjects with asthma.
Topics: Adult; Aged; Asthma; Benzoquinones; Bronchi; Dose-Response Relationship, Drug; Drug Synergism; Female; Forced Expiratory Volume; Heptanoic Acids; Humans; Male; Methacholine Chloride; Middle Aged; Quinones; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Vital Capacity | 1991 |
Urinary leukotriene E4 concentrations increase after aspirin challenge in aspirin-sensitive asthmatic subjects.
Topics: Adult; Aspirin; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Leukotriene E4; Male; Methacholine Chloride; Middle Aged; SRS-A | 1991 |
The effect of nedocromil sodium on the early and late reaction and allergen-induced bronchial hyperresponsiveness.
Topics: Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchi; Bronchial Provocation Tests; Dust; Female; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Male; Methacholine Chloride; Mites; Nedocromil; Quinolones; Time Factors | 1991 |
The protective effect of a beta 2 agonist against excessive airway narrowing in response to bronchoconstrictor stimuli in asthma and chronic obstructive lung disease.
Topics: Adult; Aged; Airway Obstruction; Albuterol; Asthma; Bronchoconstriction; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Histamine; Humans; Lung Diseases, Obstructive; Male; Methacholine Chloride; Middle Aged | 1991 |
Transdermal delivery of the alpha 2-agonist clonidine does not alter airways responses to inhaled histamine or methacholine.
Topics: Administration, Cutaneous; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Clonidine; Double-Blind Method; Histamine; Humans; Methacholine Chloride | 1991 |
Effect of inhaled prostaglandin E2 on bronchial reactivity to sodium metabisulphite and methacholine in patients with asthma.
Topics: Adolescent; Adult; Asthma; Bronchoconstriction; Dinoprostone; Dose-Response Relationship, Drug; Double-Blind Method; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Random Allocation; Sulfites | 1991 |
Duration of the effect of astemizole on histamine-inhalation tests.
Topics: Administration, Inhalation; Adult; Aged; Astemizole; Asthma; Benzimidazoles; Bronchial Provocation Tests; Double-Blind Method; Female; Forced Expiratory Volume; Histamine; Histamine H1 Antagonists; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Peak Expiratory Flow Rate; Random Allocation; Skin Tests; Vital Capacity | 1990 |
The effect of inhaled corticosteroids on the maximal degree of airway narrowing to methacholine in asthmatic subjects.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchodilator Agents; Budesonide; Dose-Response Relationship, Drug; Double-Blind Method; Forced Expiratory Volume; Humans; Methacholine Chloride; Pregnenediones; Random Allocation | 1991 |
Reduction of budesonide after a year of increased use: a randomized controlled trial to evaluate whether improvements in airway responsiveness and clinical asthma are maintained.
Topics: Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Budesonide; Double-Blind Method; Follow-Up Studies; Forced Expiratory Volume; Humans; Methacholine Chloride; Pregnenediones; Pulmonary Ventilation; Remission Induction; Time Factors | 1991 |
Effect of inhaled beclomethasone dipropionate on bronchial hyperreactivity in asthmatic children during maximal allergen exposure.
Topics: Allergens; Asthma; Beclomethasone; Bronchial Provocation Tests; Bronchoconstriction; Child; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Nebulizers and Vaporizers | 1991 |
Local immunotherapy with Dermatophagoides extract in asthma.
Topics: Adolescent; Adult; Allergens; Antigens, Dermatophagoides; Asthma; Bronchial Provocation Tests; Double-Blind Method; Female; Humans; Immunotherapy; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate | 1991 |
Methacholine challenges in the management of young children.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Child; Child, Preschool; Chronic Disease; Diagnosis, Computer-Assisted; Female; Humans; Lung; Male; Methacholine Chloride; Respiration | 1991 |
Theophylline inhibits early and late asthmatic reactions induced by allergens in asthmatic subjects.
Topics: Administration, Oral; Adolescent; Adult; Allergens; Asthma; Bronchial Provocation Tests; Delayed-Action Preparations; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Theophylline | 1991 |
Bronchial responsiveness during regular fenoterol therapy: four months prospective study.
Topics: Adolescent; Adult; Aerosols; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Confidence Intervals; Female; Fenoterol; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Prospective Studies; Spirometry | 1991 |
Effects of PAF antagonist, BN52021, on the PAF-, methacholine-, and allergen-induced bronchoconstriction in asthmatic children.
Topics: Allergens; Asthma; Blood Cell Count; Bronchial Provocation Tests; Bronchoconstriction; Child; Diterpenes; Double-Blind Method; Female; Ginkgolides; Humans; Lactones; Male; Methacholine Chloride; Plant Extracts; Platelet Activating Factor | 1991 |
Effect of hyperoxia on bronchial response to inhaled methacholine.
Topics: Administration, Inhalation; Adult; Asthma; Asthma, Exercise-Induced; Bronchi; Bronchial Provocation Tests; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Oxygen; Random Allocation | 1991 |
An open-label study of high-dose intravenous immunoglobulin in severe childhood asthma.
Topics: Acute Disease; Adolescent; Asthma; Bronchial Provocation Tests; Child; Combined Modality Therapy; Humans; Immunization, Passive; Immunoglobulins; Infusions, Intravenous; Methacholine Chloride; Respiratory Function Tests; Skin Tests | 1991 |
Inhaled verapamil-induced bronchoconstriction in mild asthma.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Exercise Test; Female; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Single-Blind Method; Verapamil; Vital Capacity | 1991 |
Long-term effects of budesonide on airway responsiveness and clinical asthma severity in inhaled steroid-dependent asthmatics.
Topics: Administration, Inhalation; Adult; Asthma; Beclomethasone; Bronchodilator Agents; Budesonide; Double-Blind Method; Drug Evaluation; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Pregnenediones; Substance-Related Disorders; Time Factors | 1990 |
A double-blind, randomized study of sodium cromoglycate versus placebo in patients with cystic fibrosis and bronchial hyperreactivity.
Topics: Adolescent; Adult; Asthma; Bronchi; Bronchial Provocation Tests; Child; Cromolyn Sodium; Cystic Fibrosis; Double-Blind Method; Forced Expiratory Volume; Humans; Methacholine Chloride; Methacholine Compounds; Placebos; Randomized Controlled Trials as Topic; Respiratory Hypersensitivity; Time Factors | 1990 |
Adenosine-induced bronchoconstriction in human asthmatics: effects of pretreatment with indomethacin or atropine sulfate.
Topics: Adenosine; Administration, Inhalation; Administration, Oral; Adult; Asthma; Atropine; Bronchial Provocation Tests; Bronchoconstrictor Agents; Double-Blind Method; Humans; Indomethacin; Male; Methacholine Chloride | 1990 |
Comparison of the effect of loratadine on the airway and skin responses to histamine, methacholine, and allergen in subjects with asthma.
Topics: Adult; Allergens; Asthma; Bronchi; Bronchial Provocation Tests; Cyproheptadine; Female; Histamine; Histamine Antagonists; Humans; Loratadine; Methacholine Chloride; Middle Aged; Skin; Skin Tests | 1990 |
The long-term effects of nedocromil sodium and beclomethasone dipropionate on bronchial responsiveness to methacholine in nonatopic asthmatic subjects.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Beclomethasone; Bronchi; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Nedocromil; Quinolones; Skin Tests | 1990 |
Changes in airway resistance following nasal provocation.
Topics: Adult; Airway Resistance; Asthma; Bronchi; Double-Blind Method; Female; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Nasal Mucosa; Nasal Provocation Tests; Phenylephrine; Plethysmography; Prospective Studies; Random Allocation; Reflex; Rhinitis, Allergic, Seasonal | 1990 |
Effect of ketanserin, a new blocking agent of the 5-HT2 receptor, on airway responsiveness in asthma.
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Child; Dose-Response Relationship, Immunologic; Female; Forced Expiratory Volume; Humans; Ketanserin; Male; Methacholine Chloride; Methacholine Compounds; Serotonin Antagonists | 1990 |
Relationship of different serum levels of theophylline on methacholine sensitivity.
Topics: Adult; Asthma; Bronchial Provocation Tests; Drug Administration Schedule; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Theophylline | 1990 |
Comparative protective effect of the inhaled beta 2-agonist salbutamol (albuterol) on bronchoconstriction provoked by histamine, methacholine, and adenosine 5'-monophosphate in asthma.
Topics: Adenosine Monophosphate; Administration, Inhalation; Adolescent; Adult; Aerosols; Albuterol; Asthma; Bronchial Spasm; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1990 |
[Methodologic comparison of the polyfrequency oscillation method, transcutaneous oxygen pressure measurement and body plethysmography in bronchial provocation with methacholine].
Topics: Airway Resistance; Asthma; Blood Gas Monitoring, Transcutaneous; Bronchial Provocation Tests; Humans; Methacholine Chloride; Methacholine Compounds; Oscillometry; Plethysmography, Whole Body; Respiratory Hypersensitivity | 1990 |
Effect of low-dose troleandomycin on glucocorticoid pharmacokinetics and airway hyperresponsiveness in severely asthmatic children.
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Child; Dose-Response Relationship, Drug; Glucocorticoids; Humans; Methacholine Chloride; Methacholine Compounds; Methylprednisolone; Prednisolone; Respiratory Function Tests; Respiratory Hypersensitivity; Troleandomycin | 1990 |
Venous blood platelets decrease during allergen-induced asthmatic reactions.
Topics: Adolescent; Adult; Animals; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Leukocyte Count; Leukocytosis; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Mites; Platelet Count; Pollen; Thrombocytopenia | 1990 |
Inhibition of adenosine 5'-monophosphate- and methacholine-induced bronchoconstriction in asthma by inhaled frusemide.
Topics: Adenosine Monophosphate; Administration, Inhalation; Adult; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Double-Blind Method; Female; Forced Expiratory Volume; Furosemide; Humans; Male; Methacholine Chloride; Methacholine Compounds; Randomized Controlled Trials as Topic | 1990 |
The airways effects of inhaled chlorbutol in asthmatic subjects.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Chlorobutanol; Double-Blind Method; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Nebulizers and Vaporizers; Terbutaline | 1990 |
Effect of inhaled furosemide on metabisulfite- and methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects.
Topics: Administration, Inhalation; Adult; Amiloride; Asthma; Bronchi; Bronchial Provocation Tests; Double-Blind Method; Female; Furosemide; Humans; Male; Membrane Potentials; Methacholine Chloride; Methacholine Compounds; Nasal Mucosa; Randomized Controlled Trials as Topic; Sulfites | 1990 |
Endogenous opioids modulate the increase in ventilatory output and dyspnea during severe acute bronchoconstriction.
Topics: Acute Disease; Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Double-Blind Method; Dyspnea; Endorphins; Humans; Male; Methacholine Chloride; Middle Aged; Naloxone; Random Allocation; Respiration; Respiratory Mechanics | 1990 |
Comparison of the effects of inhaled corticosteroids on the airway response to histamine, methacholine, hyperventilation, and sulfur dioxide in subjects with asthma.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Airway Resistance; Albuterol; Asthma; Beclomethasone; Bronchi; Bronchial Provocation Tests; Histamine; Humans; Hyperventilation; Methacholine Chloride; Sulfur Dioxide | 1990 |
Immunotherapy for cat asthma.
Topics: Adult; Allergens; Animals; Asthma; Bronchial Provocation Tests; Cats; Desensitization, Immunologic; Drug Administration Schedule; Environmental Exposure; Female; Histamine Release; Humans; Immunoglobulin E; Immunoglobulin G; Injections, Intradermal; Leukocytes; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Serum Albumin; Skin Tests | 1988 |
Cromolyn sodium is effective in adult chronic asthmatics.
Topics: Adolescent; Adult; Aged; Asthma; Bronchodilator Agents; Chronic Disease; Clinical Trials as Topic; Cromolyn Sodium; Drug Therapy, Combination; Humans; Methacholine Chloride; Methacholine Compounds; Middle Aged; Pulmonary Ventilation | 1989 |
Theophylline does not inhibit allergen-induced increase in airway responsiveness to methacholine.
Topics: Adult; Airway Resistance; Allergens; Asthma; Bronchial Provocation Tests; Cromolyn Sodium; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Random Allocation; Theophylline | 1989 |
Is there loss of protective muscarinic receptor mechanism in asthma?
Topics: Adult; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Drug Interactions; Female; Histamine; Humans; Ipratropium; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Random Allocation; Receptors, Muscarinic; Respiratory Function Tests | 1989 |
Characterisation of bronchoconstrictor responses to sodium metabisulphite aerosol in atopic subjects with and without asthma.
Topics: Adult; Aerosols; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Ipratropium; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Pulmonary Ventilation; Sulfites; Time Factors | 1989 |
Ketotifen does not inhibit asthmatic reactions induced by toluene di-isocyanate in sensitized subjects.
Topics: Asthma; Cyanates; Double-Blind Method; Forced Expiratory Volume; Humans; Hypersensitivity, Delayed; Immunization; Ketotifen; Methacholine Chloride; Methacholine Compounds; Random Allocation; Toluene 2,4-Diisocyanate | 1989 |
Airway responsiveness to methacholine after inhalation of nebulized hypertonic saline in bronchial asthma.
Topics: Administration, Inhalation; Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Muscle, Smooth; Nebulizers and Vaporizers; Saline Solution, Hypertonic; Sodium Chloride | 1989 |
Anticholinergic blockade of beta-blocker-induced bronchoconstriction.
Topics: Adult; Asthma; Bronchi; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Isoproterenol; Male; Methacholine Chloride; Methacholine Compounds; Parasympatholytics; Propranolol; Pulmonary Ventilation; Random Allocation; Scopolamine Derivatives | 1989 |
[Effect of calcium channel blocking agents on methacholine-induced airway hyperreactivity in subjects with asthmatic bronchitis, asthma and cor pulmonale].
Topics: Adult; Aged; Asthma; Bronchi; Bronchial Provocation Tests; Bronchitis; Calcium Channel Blockers; Double-Blind Method; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Pulmonary Heart Disease; Respiratory Function Tests | 1989 |
Differential effects of nifedipine and diltiazem on methacholine-induced bronchospasm in allergic asthma.
Topics: Adult; Asthma; Blood Pressure; Bronchial Provocation Tests; Bronchial Spasm; Clinical Trials as Topic; Diltiazem; Female; Forced Expiratory Volume; Heart Rate; Humans; Male; Methacholine Chloride; Methacholine Compounds; Nifedipine; Placebos; Random Allocation | 1989 |
Effect of theophylline on airway responses to inhaled platelet-activating factor in man.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Double-Blind Method; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Platelet Activating Factor; Randomized Controlled Trials as Topic; Theophylline | 1989 |
Is a myogenic response involved in deep inspiration-induced bronchoconstriction in asthmatics?
Topics: Airway Resistance; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Humans; Methacholine Chloride; Methacholine Compounds; Muscle, Smooth; Nifedipine; Respiration; Trachea | 1989 |
Effect of nisoldipine (BAY k 5552) on methacholine-induced bronchoconstriction in patients with nonspecific bronchial hyperreactivity.
Topics: Asthma; Bronchi; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Methacholine Chloride; Methacholine Compounds; Nisoldipine; Randomized Controlled Trials as Topic; Respiratory Hypersensitivity; Rhinitis, Allergic, Perennial | 1989 |
Effect of theophylline and enprofylline on bronchial hyperresponsiveness.
Topics: Adult; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Bronchodilator Agents; Double-Blind Method; Drug Administration Schedule; Forced Expiratory Volume; Humans; Injections, Intravenous; Male; Methacholine Chloride; Methacholine Compounds; Theophylline; Xanthine; Xanthines | 1989 |
Changes in bronchial reactivity in asthmatic children after treatment with beclomethasone alone or in association with salbutamol.
Topics: Adolescent; Albuterol; Asthma; Beclomethasone; Bronchi; Child; Drug Combinations; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride | 1989 |
Protective effect of antiasthma drugs on late asthmatic reactions and increased airway responsiveness induced by toluene diisocyanate in sensitized subjects.
Topics: Asthma; Beclomethasone; Bronchial Provocation Tests; Clinical Trials as Topic; Cromolyn Sodium; Cyanates; Delayed-Action Preparations; Double-Blind Method; Forced Expiratory Volume; Humans; Immunization; Lung; Methacholine Chloride; Methacholine Compounds; Placebos; Random Allocation; Respiratory System; Theophylline; Time Factors; Toluene 2,4-Diisocyanate; Verapamil | 1987 |
[Bronchial adrenergic receptors and asthma. Tachyphylaxis and its prevention].
Topics: Adrenal Cortex Hormones; Asthma; Bronchi; Humans; Ketotifen; Methacholine Chloride; Methacholine Compounds; Receptors, Adrenergic, beta; Sympathomimetics; Tachyphylaxis | 1988 |
Relaxation decreases large-airway but not small-airway asthma.
Topics: Adult; Asthma; Biofeedback, Psychology; Bronchial Provocation Tests; Desensitization, Psychologic; Electromyography; Female; Forced Expiratory Flow Rates; Helium; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Oxygen; Relaxation Therapy; Spirometry | 1986 |
Duration of oral procaterol protection from methacholine-induced bronchial obstruction.
Topics: Adrenergic beta-Agonists; Airway Resistance; Albuterol; Asthma; Child; Ethanolamines; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Procaterol; Respiratory Function Tests | 1986 |
Terfenadine (Seldane) is a potent and selective histamine H1 receptor antagonist in asthmatic airways.
Topics: Adult; Asthma; Benzhydryl Compounds; Bronchi; Bronchial Provocation Tests; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Histamine; Histamine H1 Antagonists; Humans; Male; Methacholine Chloride; Methacholine Compounds; Terfenadine; Time Factors | 1987 |
Effect of terfenadine on methacholine-induced bronchoconstriction in asthma.
Topics: Adolescent; Adult; Asthma; Benzhydryl Compounds; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Forced Expiratory Volume; Histamine H1 Antagonists; Humans; Lung; Methacholine Chloride; Methacholine Compounds; Middle Aged; Random Allocation; Terfenadine | 1987 |
Effect of ipratropium bromide on repeated methacholine challenges.
Topics: Adult; Aerosols; Asthma; Atropine Derivatives; Bronchial Provocation Tests; Clinical Trials as Topic; Female; Humans; Ipratropium; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Placebos | 1985 |
Ipratropium bromide: bronchodilator action and effect on methacholine-induced bronchoconstriction.
Topics: Administration, Inhalation; Adolescent; Adult; Airway Resistance; Asthma; Atropine Derivatives; Bronchodilator Agents; Capsules; Double-Blind Method; Humans; Ipratropium; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Random Allocation | 1987 |
Respiratory dose-response study of normal and asthmatic volunteers exposed to sulfuric acid aerosol in the sub-micrometer size range.
Topics: Administration, Inhalation; Adolescent; Adult; Aerosols; Asthma; Dose-Response Relationship, Drug; Female; Humans; Irritants; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Particle Size; Physical Exertion; Random Allocation; Respiratory Function Tests; Sulfuric Acids | 1988 |
The effect of nifedipine on bronchial reactivity to inhaled histamine and methacholine: a comparative study in normal and asthmatic subjects.
Topics: Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Histamine; Humans; Lung; Male; Methacholine Chloride; Methacholine Compounds; Nifedipine | 1988 |
The inhibition of sulfur dioxide-induced bronchoconstriction in asthmatic subjects by cromolyn is dose dependent.
Topics: Adult; Airway Resistance; Asthma; Bronchial Spasm; Cromolyn Sodium; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Osmolar Concentration; Sulfur Dioxide | 1986 |
[Effect of fenoterol and disodium cromoglycate on the methacholine provocation test in bronchial asthma].
Topics: Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Cromolyn Sodium; Double-Blind Method; Female; Fenoterol; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds | 1986 |
Protective effect of disodium cromoglycate on allergen-induced bronchoconstriction and increased hyperresponsiveness: a double-blind placebo-controlled study.
Topics: Adolescent; Adrenal Cortex Hormones; Allergens; Asthma; Bronchi; Bronchial Provocation Tests; Child; Clinical Trials as Topic; Cromolyn Sodium; Double-Blind Method; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds | 1986 |
Intraesophageal perfusion of acid increases the bronchomotor response to methacholine and to isocapnic hyperventilation in asthmatic subjects.
Topics: Adolescent; Adult; Asthma; Atropine; Bronchi; Carbon Dioxide; Esophagus; Female; Gastroesophageal Reflux; Humans; Hydrochloric Acid; Hyperventilation; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Perfusion | 1986 |
Nebulised sodium cromoglycate and verapamil in methacholine induced asthma.
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Child; Cromolyn Sodium; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Nebulizers and Vaporizers; Respiratory System; Verapamil | 1987 |
Isotonic nebulized disodium cromoglycate provides better protection against methacholine- and exercise-induced bronchoconstriction.
Topics: Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Bronchial Spasm; Cromolyn Sodium; Forced Expiratory Volume; Humans; Hypotonic Solutions; Isotonic Solutions; Methacholine Chloride; Methacholine Compounds; Nebulizers and Vaporizers | 1988 |
Dosage and time effects of inhaled budesonide on bronchial hyperreactivity.
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Bronchi; Bronchial Provocation Tests; Budesonide; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Eosinophils; Female; Forced Expiratory Volume; Humans; Hydrocortisone; Leukocyte Count; Male; Methacholine Chloride; Methacholine Compounds; Pregnenediones; Random Allocation | 1988 |
Influence of infused adenosine on bronchial tone and bronchial reactivity in asthma.
Topics: Adenosine; Adult; Asthma; Blood Pressure; Bronchi; Bronchial Provocation Tests; Female; Heart Rate; Humans; Infusions, Intravenous; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Muscle, Smooth; Respiratory Function Tests | 1988 |
Re-examination of the late asthmatic response to exercise.
Topics: Adult; Air; Airway Obstruction; Asthma; Bronchial Provocation Tests; Cold Temperature; Female; Forced Expiratory Volume; Hot Temperature; Humans; Humidity; Male; Methacholine Chloride; Methacholine Compounds; Physical Exertion; Time Factors | 1988 |
Dose-response of inhaled diltiazem on airway reactivity to methacholine and exercise in subjects with mild asthma.
Topics: Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Diltiazem; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Physical Exertion; Random Allocation | 1988 |
Dose response of inhaled gallopamil (D600), a calcium channel blocker, in attenuating airway reactivity to methacholine and exercise.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Dose-Response Relationship, Drug; Double-Blind Method; Exercise Test; Female; Forced Expiratory Volume; Gallopamil; Humans; Male; Methacholine Chloride; Methacholine Compounds; Random Allocation | 1988 |
A comparison of histamine and methacholine bronchial challenges using the DeVilbiss 646 nebulizer and the Rosenthal-French dosimeter.
Topics: Adult; Asthma; Bronchial Provocation Tests; Clinical Trials as Topic; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1987 |
The effect of oral diltiazem on airway reactivity to methacholine and exercise in subjects with mild intermittent asthma.
Topics: Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Diltiazem; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Heart Rate; Humans; Male; Methacholine Chloride; Methacholine Compounds; Physical Exertion; Random Allocation | 1987 |
Airway responses to nitrogen dioxide in asthmatic subjects.
Topics: Adult; Air Pollutants; Asthma; Female; Humans; Lung; Male; Methacholine Chloride; Methacholine Compounds; Microclimate; Nitrogen Dioxide; Respiratory Function Tests; Respiratory System | 1987 |
Duration of protection by oxitropium bromide against cholinergic challenge.
Topics: Adolescent; Adult; Asthma; Bronchi; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Parasympatholytics; Parasympathomimetics; Respiratory Function Tests; Scopolamine Derivatives | 1987 |
Effects of the calcium channel blocker, verapamil, on asthmatic airway responses to muscarinic, histaminergic, and allergenic stimuli.
Topics: Adult; Allergens; Asthma; Calcium Channel Blockers; Forced Expiratory Volume; Histamine; Humans; Lung; Male; Methacholine Chloride; Methacholine Compounds; Verapamil | 1986 |
Effect of diltiazem on methacholine-induced bronchoconstriction in extrinsic asthmatics.
Topics: Adolescent; Adult; Airway Resistance; Asthma; Benzazepines; Bronchi; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1986 |
The combined effects of two pairs of mediators, adenosine with methacholine and prostaglandin D2 with histamine, on airway calibre in asthma.
Topics: Adenosine; Adult; Airway Resistance; Asthma; Bronchi; Dose-Response Relationship, Drug; Drug Synergism; Female; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Prostaglandins D; Time Factors | 1986 |
Evaluation of the asthmogenicity of propafenone, a new antiarrhythmic drug. Comparison of spirometry with methacholine challenge.
Topics: Adult; Asthma; Forced Expiratory Volume; Heart; Humans; Methacholine Chloride; Methacholine Compounds; Propafenone | 1986 |
Effect of nifedipine on arterial hypoxaemia occurring after methacholine challenge in asthma.
Topics: Adult; Airway Resistance; Asthma; Clinical Trials as Topic; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Nifedipine; Pulmonary Gas Exchange; Random Allocation; Vital Capacity | 1986 |
Effect of long-term treatment with inhaled corticosteroids and beta-agonists on the bronchial responsiveness in children with asthma.
Topics: Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Asthma; Bronchi; Budesonide; Child; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Pregnenediones; Respiratory Function Tests; Terbutaline; Time Factors | 1987 |
The effect of ketotifen on bronchial hyperreactivity in childhood asthma.
Topics: Adolescent; Asthma; Bronchial Spasm; Child; Female; Humans; Ketotifen; Male; Methacholine Chloride; Methacholine Compounds | 1985 |
Acute effect of ketotifen on the dose-response curve of histamine and methacholine in asthma.
Topics: Adolescent; Adult; Aged; Asthma; Bronchi; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Histamine; Humans; Ketotifen; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1985 |
Protective effect by UCB JO28 against histamine and methacholine induced bronchial hyperreactivity.
Topics: Adolescent; Adult; Asthma; Bronchial Spasm; Clinical Trials as Topic; Female; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Piperidines; Prospective Studies | 1985 |
1729 other study(ies) available for methacholine chloride and Asthma, Bronchial
| Article | Year |
|---|---|
Allergic sensitisation did not affect bronchial hyper-responsiveness in children without respiratory tract symptoms.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Female; Humans; Male; Methacholine Chloride; Respiratory System; Skin Tests | 2022 |
Metformin prevents airway hyperreactivity in rats with dietary obesity.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Diet, High-Fat; Female; Glucose; Hyperinsulinism; Hypoglycemic Agents; Male; Metformin; Methacholine Chloride; Obesity; Rats; Rats, Sprague-Dawley; Vagus Nerve; Weight Gain | 2021 |
Predictors of Airway Hyperresponsiveness in Symptomatic Children with Normal Spirometry and Suspicious of Possible Asthma.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Cough; Forced Expiratory Volume; Humans; Methacholine Chloride; Respiratory Hypersensitivity; Respiratory Sounds; Retrospective Studies; Spirometry | 2022 |
Assessment and outcomes of firefighter applicants with possible asthma.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Firefighters; Forced Expiratory Volume; Humans; Methacholine Chloride | 2022 |
Therapeutic ketosis decreases methacholine hyperresponsiveness in mouse models of inherent obese asthma.
Topics: 3-Hydroxybutyric Acid; Animals; Asthma; Bronchial Hyperreactivity; Diet, High-Fat; Diet, Ketogenic; Disease Models, Animal; Esters; Gastrointestinal Microbiome; Ketone Bodies; Ketosis; Male; Methacholine Chloride; Mice, Inbred C57BL; Obesity; Weight Loss | 2022 |
Rho-kinase inhibitors protect against neonatal hyperoxia-induced airway hyperreactivity in a rat pup model: Role of prostaglandin F
Topics: Animals; Animals, Newborn; Asthma; Humans; Hyperoxia; Methacholine Chloride; Prostaglandins; Prostaglandins F; Rats; rho-Associated Kinases | 2022 |
Azithromycin inhibits mucin secretion, mucous metaplasia, airway inflammation, and airways hyperresponsiveness in mice exposed to house dust mite extract.
Topics: Adenosine Triphosphate; Allergens; Animals; Asthma; Azithromycin; Disease Models, Animal; Inflammation; Interleukin-13; Metaplasia; Methacholine Chloride; Mice; Mucins; Mucus; Pyroglyphidae | 2022 |
Role of hyperpnea in the relaxant effect of inspired CO
Topics: Airway Resistance; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Carbon Dioxide; Humans; Hypercapnia; Hyperventilation; Methacholine Chloride | 2022 |
Ethanol extract of Veronica persica ameliorates house dust mite-induced asthmatic inflammation by inhibiting STAT-3 and STAT-6 activation.
Topics: Animals; Asthma; Cytokines; Ethanol; Immunoglobulin E; Inflammation; Lung; Methacholine Chloride; Mice; Pyroglyphidae; Veronica | 2022 |
Measurement of Airway Hyperresponsiveness in Mice.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Eosinophilia; Immunoglobulin E; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiration Disorders; Respiratory Hypersensitivity | 2022 |
Imidazobenzodiazepine PI320 Relaxes Mouse Peripheral Airways by Inhibiting Calcium Mobilization.
Topics: Animals; Asthma; Calcium; Calcium Signaling; Flumazenil; gamma-Aminobutyric Acid; Inositol; Ligands; Lung; Methacholine Chloride; Mice; Muscle Contraction; Muscle, Smooth; Picrotoxin | 2022 |
Longitudinal follow-up of the asthma status in a French-Canadian cohort.
Topics: Asthma; Canada; Follow-Up Studies; Forced Expiratory Volume; Humans; Methacholine Chloride | 2022 |
Characteristics of Breath Sounds During Methacholine-induced Bronchoconstriction in Children with Asthma.
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstriction; Child; Female; Humans; Male; Methacholine Chloride; Respiratory Sounds | 2022 |
Insulin increases sensory nerve density and reflex bronchoconstriction in obese mice.
Topics: Animals; Asthma; Bronchoconstriction; Hyperinsulinism; Insulin; Methacholine Chloride; Mice; Mice, Obese; Obesity; Receptor, Insulin; Reflex; Serotonin | 2022 |
The cumulative effect of methacholine on large and small airways when deep inspirations are avoided.
Topics: Airway Resistance; Asthma; Bronchial Provocation Tests; Forced Expiratory Volume; Humans; Lung Volume Measurements; Methacholine Chloride; Respiratory System | 2023 |
Cross-sectional study of cholinergic urticaria subtypes and bronchial hyperresponsiveness.
Topics: Asthma; Bronchial Hyperreactivity; Cholinergic Agents; Cross-Sectional Studies; Humans; Methacholine Chloride; Nitric Oxide; Urticaria | 2022 |
How does one get around many of the confounding factors influencing the response to methacholine?
Topics: Asthma; Bronchial Provocation Tests; Humans; Methacholine Chloride | 2023 |
A retro-inverso modified peptide alleviated ovalbumin-induced asthma model by affecting glycerophospholipid and purine metabolism of immune cells.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Immunoglobulin E; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Ovalbumin; Purines | 2023 |
Steady-state estradiol triggers a unique innate immune response to allergen resulting in increased airway resistance.
Topics: Airway Resistance; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Estradiol; Estrogens; Female; Immunity, Innate; Interleukin-13; Interleukin-33; Interleukin-5; Lung; Lymphocytes; Methacholine Chloride; Mice | 2023 |
Bronchial provocation testing: Should we look beyond FEV
Topics: Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Forced Expiratory Volume; Humans; Methacholine Chloride; Respiratory Function Tests | 2023 |
Calcium-Sensing Receptor Negative Allosteric Modulators Oppose Contraction of Mouse Airways.
Topics: Albuterol; Animals; Asthma; Bronchodilator Agents; Guinea Pigs; HEK293 Cells; Humans; Methacholine Chloride; Mice; Receptors, Calcium-Sensing; Spermine | 2023 |
Based on what parameters is safe to discontinuate inhaled corticosteroids in children with asthma?
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Child; Humans; Methacholine Chloride | 2023 |
More airway smooth muscle in males versus females in a mouse model of asthma: A blessing in disguise?
Topics: Animals; Asthma; Bronchoconstriction; Female; Lung; Male; Methacholine Chloride; Mice; Muscle, Smooth | 2023 |
Allosteric modulator potentiates β2AR agonist-promoted bronchoprotection in asthma models.
Topics: Animals; Asthma; Binding Sites; Guinea Pigs; Humans; Ligands; Lung; Methacholine Chloride; Mice; Receptors, Adrenergic, beta-2 | 2023 |
Sphingosine-1-phosphate induces airway smooth muscle hyperresponsiveness and proliferation.
Topics: Animals; Asthma; Cell Proliferation; Humans; Methacholine Chloride; Mice; Muscle, Smooth; Sphingosine-1-Phosphate Receptors | 2023 |
Amitriptyline inhibits bronchoconstriction and directly promotes dilatation of the airways.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Albuterol; Amitriptyline; Animals; Asthma; Bronchoconstriction; Bronchodilator Agents; Dilatation; Endothelins; Guinea Pigs; Histamine; Humans; Lung; Methacholine Chloride; Mice; Rats; Serotonin; Sympathomimetics; Thromboxanes | 2023 |
Short-term effect of once-daily fluticasone furoate on methacholine-induced bronchoconstriction in mild asthmatics.
Topics: Androstadienes; Asthma; Bronchoconstriction; Humans; Methacholine Chloride; Severity of Illness Index; Time Factors | 2019 |
Tracheomalacia in bronchopulmonary dysplasia: Trachealis hyper-relaxant responses to S-nitrosoglutathione in a hyperoxic murine model.
Topics: Animals; Asthma; Bronchodilator Agents; Bronchopulmonary Dysplasia; Disease Models, Animal; Humans; Hyperoxia; Infant, Newborn; Methacholine Chloride; Mice; Muscle, Smooth; S-Nitrosoglutathione; Signal Transduction; Trachea; Tracheomalacia | 2019 |
Diagnosis of asthma in children: the contribution of a detailed history and test results.
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Child; Exhalation; Female; Forced Expiratory Volume; Humans; Male; Mannitol; Medical History Taking; Methacholine Chloride; Nitric Oxide; Pollen; Respiratory Sounds; Skin Tests; Spirometry; Vital Capacity | 2019 |
Effect modifiers of lung function and daily air pollutant variability in a panel of schoolchildren.
Topics: Air Pollutants; Air Pollution; Animals; Asthma; Bronchoconstrictor Agents; Child; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Nitrogen Dioxide; Nitrogen Oxides; Particulate Matter; Schools; Severity of Illness Index; South Africa; Spirometry; Sulfur Dioxide; Time Factors | 2019 |
Bronchodilation Test with Inhaled Salbutamol Versus Bronchial Methacholine Challenge to Make an Asthma Diagnosis: Do They Provide the Same Information?
Topics: Albuterol; Asthma; Bronchial Provocation Tests; Forced Expiratory Volume; Humans; Methacholine Chloride; Retrospective Studies | 2020 |
Shortening of airway smooth muscle is modulated by prolonging the time without simulated deep inspirations in ovine tracheal strips.
Topics: Airway Resistance; Animals; Asthma; Bronchi; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Female; Inhalation; Isoproterenol; Male; Methacholine Chloride; Muscle, Smooth; Sheep; Trachea | 2019 |
Factors associated with exhaled nitric oxide in children with asthma and allergic rhinitis.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Bronchial Hyperreactivity; Case-Control Studies; Child; Child, Preschool; China; Drug Therapy, Combination; Eosinophils; Exhalation; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Nitric Oxide; Respiratory Function Tests; Rhinitis, Allergic; Skin Tests | 2020 |
Beneficial Effects of Neurotensin in Murine Model of Hapten-Induced Asthma.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Gene Expression Regulation; Haptens; Humans; Injections, Intraperitoneal; Leukocytes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neurotensin; Pyrazoles; Quinolines | 2019 |
Diagnostic value of the hypertonic saline bronchial provocation test in children with asthma using the high-power aerosol provocation system.
Topics: Aerosols; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Child, Preschool; Cough; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Respiratory Sounds; Saline Solution, Hypertonic | 2021 |
Concurrence of elevated FeNO and airway hyperresponsiveness in nonasthmatic adolescents.
Topics: Adolescent; Adult; Asthma; Biomarkers; Bronchial Hyperreactivity; Child; Eosinophils; Exhalation; Female; Follow-Up Studies; Humans; Leukocyte Count; Lipocalins; Male; Methacholine Chloride; Nitric Oxide; Respiratory System; Young Adult | 2020 |
Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch.
Topics: Animals; Asthma; Bronchoconstrictor Agents; Cells, Cultured; Disease Models, Animal; Female; Glycolysis; Humans; Hydrogen; Lactic Acid; Leukocytes, Mononuclear; Lung; Male; Methacholine Chloride; Mice; Middle Aged; Ovalbumin; Oxidative Phosphorylation; Primary Cell Culture | 2020 |
Modification of lung endoplasmic reticulum genes expression and NF-kB protein levels in obese ovalbumin-sensitized male and female rats.
Topics: Animals; Asthma; Diet, High-Fat; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Female; Gene Expression Regulation; HSP70 Heat-Shock Proteins; Leptin; Lung; Male; Membrane Proteins; Methacholine Chloride; NF-kappa B; Obesity; Ovalbumin; Rats; Rats, Wistar; Signal Transduction; Time Factors | 2020 |
Prefrontal cortex activation is associated with dyspnea during methacholine bronchial provocation tests in patients with bronchial asthma.
Topics: Asthma; Bronchial Provocation Tests; Dyspnea; Humans; Methacholine Chloride; Prefrontal Cortex | 2020 |
Cysteinyl Leukotriene Synthesis via Phospholipase A2 Group IV Mediates Exercise-induced Bronchoconstriction and Airway Remodeling.
Topics: Acetates; Airway Remodeling; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Cyclopropanes; Cysteine; Female; Group II Phospholipases A2; Leukotrienes; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Physical Conditioning, Animal; Quinolines; Respiratory Hypersensitivity; Sulfides | 2020 |
Predictive value of childhood airway hyper-responsiveness to indirect stimuli: 10-year longitudinal study.
Topics: Adolescent; Asthma; Breath Tests; Bronchial Provocation Tests; Child; Child, Preschool; Female; Humans; Longitudinal Studies; Male; Methacholine Chloride; Nitric Oxide; Prognosis; Respiratory Function Tests; Respiratory Hypersensitivity; Respiratory Sounds; Spirometry; Surveys and Questionnaires | 2020 |
Acute salbutamol bronchoprotection against methacholine: Asthma compared with chronic obstructive pulmonary disease.
Topics: Albuterol; Asthma; Bronchoconstrictor Agents; Disease Management; Female; Humans; Male; Methacholine Chloride; Pulmonary Disease, Chronic Obstructive; Treatment Outcome | 2020 |
Rosuvastatin Affects Tracheal Responsiveness, Bronchoalveolar Lavage Inflammatory Cells, and Oxidative Stress Markers in Hyperlipidemic and Asthmatic Rats.
Topics: Allergens; Animals; Anticholesteremic Agents; Asthma; Bronchoalveolar Lavage Fluid; Hyperlipidemias; Leukocyte Count; Lipids; Male; Methacholine Chloride; Ovalbumin; Oxidative Stress; Rats, Wistar; Rosuvastatin Calcium; Trachea | 2019 |
Predictive value of non-specific bronchial challenge testing for respiratory symptoms and lung function in aluminium smelter workers.
Topics: Adult; Aluminum; Asthma; Bronchial Provocation Tests; Cohort Studies; Cough; Female; Humans; Longitudinal Studies; Lung Diseases; Male; Metallurgy; Methacholine Chloride; Occupational Diseases; Respiratory Function Tests; Respiratory Sounds; Surveys and Questionnaires; Victoria | 2020 |
Performance Characteristics of Spirometry With Negative Bronchodilator Response and Methacholine Challenge Testing and Implications for Asthma Diagnosis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Cohort Studies; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Predictive Value of Tests; Spirometry; Young Adult | 2020 |
Assessment of diagnostic accuracy of lung function indices and FeNO for a positive methacholine challenge.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Asthmatic Agents; Asthma; Breath Tests; Bronchi; Female; Humans; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Plethysmography, Whole Body; Reproducibility of Results; Respiratory Function Tests | 2020 |
Airway Hyperresponsiveness Is Severe and Persistent in an Equine Model of Neutrophilic Asthma.
Topics: Airway Remodeling; Animals; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Disease Models, Animal; Horse Diseases; Horses; Humans; Methacholine Chloride; Neutrophils; Respiratory Hypersensitivity; Species Specificity | 2020 |
Airway hyperresponsiveness to mannitol improves in both type 2 high and type 2 low asthma after specialist management.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Ambulatory Care Facilities; Asthma; Eosinophils; Female; Humans; Male; Mannitol; Methacholine Chloride; Middle Aged; Nitric Oxide; Specialization; Sputum; Treatment Outcome; Young Adult | 2021 |
Pulmonary delivery of ORMDL3 short hairpin RNA - a potential tool to regulate allergen-induced airway inflammation.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Inflammation; Lung; Male; Membrane Proteins; Methacholine Chloride; Mice; Mice, Knockout; Mice, Transgenic; Pulmonary Eosinophilia; Respiratory Hypersensitivity; RNA Interference; RNA, Small Interfering | 2020 |
Methacholine Challenge Testing in the Diagnosis of Asthma.
Topics: Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Humans; Methacholine Chloride; Spirometry | 2020 |
The Effect of Bronchoconstriction by Methacholine Inhalation in a Murine Model of Asthma.
Topics: Administration, Inhalation; Allergens; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Eosinophils; Female; Humans; Lung; Macrophages; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Transforming Growth Factor beta | 2020 |
Allergen inhalation generates pro-inflammatory oxidised phosphatidylcholine associated with airway dysfunction.
Topics: Administration, Inhalation; Allergens; Animals; Asthma; Humans; Methacholine Chloride; Mice; Phosphatidylcholines | 2021 |
Anti-Inflammatory Effects of a
Topics: Animals; Anti-Inflammatory Agents; Asthma; beta-N-Acetylhexosaminidases; Body Weight; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Capsaicin; Cordyceps; Cytokines; Disease Models, Animal; Eosinophil Peroxidase; Female; Histamine Release; Immunization; Immunoglobulin E; Mast Cells; Methacholine Chloride; Mice, Inbred BALB C; Mycelium; Nasal Lavage; Ovalbumin; Rats, Sprague-Dawley; Rhinitis, Allergic; Skin; Spleen; Trachea | 2020 |
Altered airway mechanics in the context of obesity and asthma.
Topics: Asthma; Bronchial Provocation Tests; Forced Expiratory Volume; Humans; Methacholine Chloride; Obesity | 2021 |
Usefulness of extended nitric oxide analysis in children with allergic rhinitis.
Topics: Asthma; Bronchi; Bronchial Hyperreactivity; Child; Humans; Methacholine Chloride; Nitric Oxide; Rhinitis, Allergic | 2022 |
TMT-based quantitative proteomics reveals suppression of SLC3A2 and ATP1A3 expression contributes to the inhibitory role of acupuncture on airway inflammation in an OVA-induced mouse asthma model.
Topics: Acupuncture Therapy; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Fusion Regulatory Protein 1, Heavy Chain; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucus; Ovalbumin; Proteomics; Respiratory Hypersensitivity; Sodium-Potassium-Exchanging ATPase | 2021 |
Mast cell-derived serotonin enhances methacholine-induced airway hyperresponsiveness in house dust mite-induced experimental asthma.
Topics: Animals; Asthma; Disease Models, Animal; Humans; Lung; Mast Cells; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pyroglyphidae; Serotonin | 2021 |
Small airway dysfunction in patients with cough variant asthma: a retrospective cohort study.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cough; Dose-Response Relationship, Drug; Eosinophil Cationic Protein; Eosinophils; Female; Forced Expiratory Volume; Humans; Leukocyte Count; Male; Methacholine Chloride; Middle Aged; Multivariate Analysis; Retrospective Studies; Sputum | 2021 |
It is high time for the scholarly societies to standardize the bronchodilator responsiveness in children.
Topics: Albuterol; Asthma; Bronchodilator Agents; Child; Humans; Methacholine Chloride; Nitric Oxide; Spirometry | 2021 |
Comparison of spirometry and impulse oscillometry in methacholine challenge test for the detection of airway hyperresponsiveness in adults.
Topics: Adult; Airway Obstruction; Airway Resistance; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Oscillometry; Respiratory Function Tests; Respiratory Hypersensitivity; ROC Curve; Sensitivity and Specificity; Spirometry | 2021 |
Blood eosinophils, FeNO and small airways dysfunction in predicting airway hyperresponsiveness in patients with asthma-like symptoms.
Topics: Asthma; Bronchial Provocation Tests; Eosinophils; Forced Expiratory Volume; Humans; Methacholine Chloride; Nitric Oxide; Respiratory Hypersensitivity; Spirometry | 2022 |
Baseline spirometry parameters as predictors of airway hyperreactivity in adults with suspected asthma.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Sectional Studies; Female; Forced Expiratory Volume; Humans; Israel; Logistic Models; Male; Methacholine Chloride; Predictive Value of Tests; Retrospective Studies; ROC Curve; Spirometry; Vital Capacity; Young Adult | 2021 |
Current Asthma Prevalence Using Methacholine Challenge Test in Korean Children from 2010 to 2014.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Cross-Sectional Studies; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Prevalence; Republic of Korea; Respiratory Sounds; Surveys and Questionnaires | 2021 |
Spirometric Response to Bronchodilator and Eucapnic Voluntary Hyperpnea in Adults With Asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Retrospective Studies; Young Adult | 2021 |
Can bronchial challenge test with adenosine or methacholine at preschool age predict school-age asthma?
Topics: Adenosine; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Child, Preschool; Female; Humans; Infant; Male; Methacholine Chloride; Schools | 2021 |
Evaluation of Supranormal Spirometry Values With an Obstructive Ratio for Airway Hyperreactivity.
Topics: Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Forced Expiratory Volume; Humans; Methacholine Chloride; Oscillometry; Spirometry | 2022 |
Safety of suspending asthma treatment before performing a methacholine challenge test.
Topics: Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Humans; Male; Methacholine Chloride; Middle Aged; Sensitivity and Specificity; Spirometry; Withholding Treatment | 2017 |
ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests.
Topics: Administration, Inhalation; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Europe; Forced Expiratory Volume; Humans; Methacholine Chloride; Nebulizers and Vaporizers; Practice Guidelines as Topic; Societies, Medical; Total Lung Capacity | 2017 |
Model-Based Estimation of Respiratory Parameters from Capnography, With Application to Diagnosing Obstructive Lung Disease.
Topics: Adult; Area Under Curve; Asthma; Capnography; Discriminant Analysis; Female; Humans; Male; Methacholine Chloride; Middle Aged; Models, Biological; Models, Statistical; Pulmonary Disease, Chronic Obstructive; Respiration; Signal Processing, Computer-Assisted; Young Adult | 2017 |
Free-breathing Functional Pulmonary MRI: Response to Bronchodilator and Bronchoprovocation in Severe Asthma.
Topics: Adult; Albuterol; Asthma; Bronchoconstrictor Agents; Bronchodilator Agents; Female; Humans; Image Processing, Computer-Assisted; Lung; Magnetic Resonance Imaging; Male; Methacholine Chloride; Middle Aged; Plethysmography; Respiration; Respiratory Function Tests; Spirometry | 2017 |
Childhood factors associated with complete and clinical asthma remission at 25 and 49 years.
Topics: Adult; Age Factors; Asthma; Breast Feeding; Child; Dermatitis, Atopic; Disease-Free Survival; Family Health; Female; Follow-Up Studies; Health Status; Humans; Male; Methacholine Chloride; Middle Aged; Netherlands; Pulmonary Medicine; Recurrence; Remission Induction; Respiratory Function Tests; Respiratory Sounds; Risk Factors; Sex Factors; Skin Tests; Smoking Cessation; Surveys and Questionnaires | 2017 |
Differences and similarities between bronchopulmonary dysplasia and asthma in schoolchildren.
Topics: Allergens; Asthma; Bronchi; Bronchial Provocation Tests; Bronchopulmonary Dysplasia; Carbon Monoxide; Child; Cross-Sectional Studies; Exhalation; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Nitric Oxide; Respiratory Function Tests | 2017 |
Increased IgE
Topics: Allergens; Asthma; B-Lymphocytes; Bone Marrow; Bone Marrow Cells; Bronchial Provocation Tests; Bronchoconstrictor Agents; Forced Expiratory Volume; Humans; Immunoglobulin E; Lymphocyte Count; Methacholine Chloride; Palatine Tonsil; Sputum | 2017 |
Symptom evaluation during the methacholine test: Does it add to the interpretation of the test results based on the PC20FEV1?
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Incidence; Israel; Male; Methacholine Chloride; Surveys and Questionnaires; Symptom Assessment | 2018 |
Lung responses in murine models of experimental asthma: Value of house dust mite over ovalbumin sensitization.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Lung; Methacholine Chloride; Mice, Inbred BALB C; Muscle, Smooth; Ovalbumin; Pneumonia; Pyroglyphidae; Respiratory Mechanics | 2018 |
Effect of airway remodeling and hyperresponsiveness on complexity of breathing pattern in rat.
Topics: Airway Remodeling; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Inflammation; Male; Methacholine Chloride; Random Allocation; Rats, Sprague-Dawley; Respiration; Respiratory Hypersensitivity; Specific Pathogen-Free Organisms | 2018 |
Sputum TWEAK expression correlates with severity and degree of control in non-eosinophilic childhood asthma.
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Child; Child, Preschool; Cross-Sectional Studies; Cytokine TWEAK; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Methacholine Chloride; Oscillometry; Severity of Illness Index; Spirometry; Sputum | 2018 |
Methacholine challenge test: Comparison of tidal breathing and dosimeter methods in children.
Topics: Asthma; Bronchial Provocation Tests; Child; Female; Humans; Male; Methacholine Chloride; Parasympathomimetics; Respiration; Retrospective Studies; Spirometry | 2018 |
Ghrelin Ameliorates Asthma by Inhibiting Endoplasmic Reticulum Stress.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Endoplasmic Reticulum; Ghrelin; Keratins; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Stress, Physiological | 2017 |
Diversity of methacholine dose-response curves among asymptomatic non-asthmatics.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Diagnosis, Differential; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Middle Aged; Randomized Controlled Trials as Topic; Risk Factors; Symptom Assessment | 2017 |
The airway hyperresponsiveness to methacholine may be predicted by impulse oscillometry and plethysmography in children with well-controlled asthma.
Topics: Adolescent; Asthma; Breath Tests; Bronchial Provocation Tests; Child; Female; Humans; Male; Methacholine Chloride; Nitric Oxide; Oscillometry; Plethysmography; Respiratory Hypersensitivity; Sensitivity and Specificity; Spirometry | 2018 |
Effect of Study Design on Sample Size in Studies Intended to Evaluate Bioequivalence of Inhaled Short-Acting β-Agonist Formulations.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Asthma; Bronchoconstrictor Agents; Bronchodilator Agents; Clinical Trials as Topic; Costs and Cost Analysis; Humans; Methacholine Chloride; Monte Carlo Method; Research Design; Therapeutic Equivalency; United States; United States Food and Drug Administration | 2018 |
Methacholine bronchial provocation test in patients with asthma: serial measurements and clinical significance.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Reference Values; Retrospective Studies | 2018 |
Standardizing dose in dosimetric bronchial challenge tests.
Topics: Administration, Inhalation; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Drug Dosage Calculations; Equipment Design; Forced Expiratory Volume; Humans; Lung; Methacholine Chloride; Nebulizers and Vaporizers; Predictive Value of Tests; Reproducibility of Results | 2018 |
Evaluation of clinically and physiologically atypical asthma: If it doesn't wheeze it may still be asthma.
Topics: Adolescent; Asthma; Asymptomatic Diseases; Bronchial Provocation Tests; Child; Child, Preschool; Female; Humans; Male; Methacholine Chloride; Oxygen; Respiratory Function Tests; Respiratory Sounds; Spirometry | 2019 |
Prevalence of airway hyperresponsiveness and its seasonal variation in children with asthma.
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Prevalence; Retrospective Studies; Seasons; Taiwan | 2018 |
Relationship between upper airway diseases, exhaled nitric oxide, and bronchial hyperresponsiveness to methacholine.
Topics: Adult; Asthma; Asthma, Aspirin-Induced; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Sectional Studies; Female; Humans; Hypersensitivity; Male; Methacholine Chloride; Middle Aged; Nasal Polyps; Nitric Oxide; Prospective Studies; Rhinitis; Smoking; Spirometry | 2019 |
Essential oil of Croton Zehntneri attenuates lung injury in the OVA-induced asthma model.
Topics: Animals; Asthma; Brazil; Croton; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Lung; Lung Injury; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Oils, Volatile; Ovalbumin; Phytotherapy; Plant Leaves; Respiratory Mechanics | 2019 |
Quantitative Imaging of Regional Aerosol Deposition, Lung Ventilation and Morphology by Synchrotron Radiation CT.
Topics: Administration, Inhalation; Aerosols; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Humans; Iodine; Lung; Methacholine Chloride; Multimodal Imaging; Pulmonary Ventilation; Rabbits; Synchrotrons; Tomography, X-Ray Computed | 2018 |
Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion.
Topics: Animals; Asthma; Disease Models, Animal; DNA Methylation; Female; Gene Deletion; Gene Expression Regulation; Immunoglobulin E; Lipid Metabolism; Liver; Lung; Male; MAP Kinase Signaling System; Membrane Proteins; Methacholine Chloride; Mice, Inbred C57BL; Mice, Knockout; Organ Specificity; Phenotype; Promoter Regions, Genetic; Respiratory Hypersensitivity; Sex Characteristics; Sphingolipids; Transcriptome | 2018 |
Early detection of airway obstruction by impulse oscillometry system in methacholine challenge testing in preschool children.
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child, Preschool; Female; Humans; Male; Methacholine Chloride; Oscillometry; Respiratory Hypersensitivity | 2018 |
[Occurrence of delayed symptoms after a challenge test with methacholine].
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchial Spasm; Delayed Diagnosis; Female; Humans; Longitudinal Studies; Male; Methacholine Chloride; Middle Aged; Prevalence; Time Factors | 2018 |
Variable ventilation decreases airway responsiveness and improves ventilation efficiency in a rat model of asthma.
Topics: Air Pressure; Animals; Asthma; Disease Models, Animal; Male; Methacholine Chloride; Oxygen; Plethysmography, Whole Body; Random Allocation; Rats, Sprague-Dawley; Respiration; Respiration, Artificial; Specific Pathogen-Free Organisms; Tidal Volume | 2018 |
Immunomodulatory innate defence regulator (IDR) peptide alleviates airway inflammation and hyper-responsiveness.
Topics: Animals; Antimicrobial Cationic Peptides; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Cell Culture Techniques; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Female; Humans; Immunomodulation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pyroglyphidae; Respiratory Hypersensitivity | 2018 |
[Guidelines for methacholine provocation testing].
Topics: Asthma; Asthma, Exercise-Induced; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; France; Humans; Methacholine Chloride; Plethysmography; Respiratory Function Tests; Spirometry | 2018 |
Curcumin affects tracheal responsiveness and lung pathology in asthmatic rats.
Topics: Animals; Asthma; Curcumin; Dexamethasone; Dose-Response Relationship, Drug; Isometric Contraction; Lung; Male; Methacholine Chloride; Ovalbumin; Rats; Trachea | 2018 |
Predicting asthma in older adults on the basis of clinical history.
Topics: Adult; Age Factors; Aged; Allergens; Asthma; Cough; Cross-Sectional Studies; Female; Forecasting; Humans; Logistic Models; Male; Methacholine Chloride; Middle Aged; Pulmonary Ventilation; Respiratory Function Tests; Respiratory Sounds; Spirometry; Young Adult | 2018 |
[Metacholine challenge: The D-dimer of asthma diagnosis?]
Topics: Asthma; Bronchial Provocation Tests; Diagnosis, Differential; Fibrin Fibrinogen Degradation Products; Humans; Methacholine Chloride; Pulmonary Embolism; Respiratory Function Tests | 2018 |
Bronchial hyper-responsiveness: a technical update.
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Humans; Male; Methacholine Chloride; Nebulizers and Vaporizers; Total Lung Capacity | 2018 |
Bacterial respiratory tract inflammation in neonatal rat model is attenuated by benzofuran through inhibition of GATA3.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Benzofurans; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; GATA3 Transcription Factor; Histocytochemistry; Inflammation; Lung; Methacholine Chloride; Rats; Serum; Treatment Outcome | 2018 |
Contractile Properties of Intrapulmonary Airway Smooth Muscle in Cystic Fibrosis.
Topics: Adult; Asthma; Bronchoconstrictor Agents; Bronchodilator Agents; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Humans; Interleukin-13; Isoproterenol; Male; Methacholine Chloride; Middle Aged; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Respiratory Hypersensitivity; Respiratory System; Young Adult | 2019 |
ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing.
Topics: Adenosine; Advisory Committees; Asthma; Bronchial Provocation Tests; Europe; Humans; Mannitol; Methacholine Chloride; Respiratory Hypersensitivity; Societies, Medical | 2018 |
Effect of CPAP on airway reactivity and airway inflammation in children with moderate-severe asthma.
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Continuous Positive Airway Pressure; Female; Forced Expiratory Volume; Humans; Inflammation; Male; Methacholine Chloride | 2019 |
Anti-thymic stromal lymphopoietin antibody suppresses airway remodeling in asthma through reduction of MMP and CTGF.
Topics: Airway Remodeling; Animals; Antibodies, Monoclonal; Asthma; Connective Tissue Growth Factor; Cytokines; Disease Models, Animal; Female; Immunoglobulin E; Inflammation; Lung; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Plethysmography; Thymic Stromal Lymphopoietin; Transforming Growth Factor beta | 2019 |
Effect of nintedanib on airway inflammation in a mouse model of acute asthma.
Topics: Acute Disease; Administration, Inhalation; Administration, Oral; Airway Remodeling; Airway Resistance; Animals; Anti-Asthmatic Agents; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Glucocorticoids; Humans; Indoles; Inflammation Mediators; Methacholine Chloride; Mice; Ovalbumin | 2020 |
Tidal breathing flow volume profiles during sleep in wheezing infants measured by impedance pneumography.
Topics: Airway Obstruction; Asthma; Electric Impedance; Exhalation; Female; Functional Residual Capacity; Humans; Infant; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Respiration; Respiratory Function Tests; Respiratory Sounds; Respiratory System; Sleep; Tidal Volume | 2019 |
Airway hyperresponsiveness in young children with respiratory symptoms: A five-year follow-up.
Topics: Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Bronchoconstriction; Child; Child, Preschool; Exercise Test; Female; Follow-Up Studies; Humans; Infant; Male; Methacholine Chloride; Prospective Studies; Respiratory Hypersensitivity; Respiratory Sounds; Skin Tests | 2019 |
Effect of High-fat Diet on Tracheal Responsiveness to Methacholine and Insulin Resistance Index in Ovalbumin-sensitized Male and Female Rats.
Topics: Allergens; Animals; Asthma; Blood Glucose; Bronchoconstrictor Agents; Diet, High-Fat; Disease Models, Animal; Female; Insulin; Insulin Resistance; Male; Methacholine Chloride; Obesity; Ovalbumin; Rats, Wistar; Trachea | 2019 |
Profiles and characteristics of bronchial responsiveness in general 7-year-old children.
Topics: Allergens; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Respiratory Sounds; Skin Tests; Spirometry | 2019 |
Airways wide shut: A physiological phenotype of asthma?
Topics: Aged; Asthma; Humans; Methacholine Chloride; Obesity; Phenotype; Respiratory System | 2019 |
Genetic Deletion of Semaphorin 3E Aggravates Airway Contraction in a Mouse Model of Allergic Asthma.
Topics: Administration, Intranasal; Animals; Asthma; Bronchoconstriction; Cytoskeletal Proteins; Disease Models, Animal; Gene Deletion; Gene Expression; Lung; Membrane Proteins; Methacholine Chloride; Mice; Mice, Knockout; Microtomy; Pyroglyphidae; Recombinant Proteins; Semaphorins; Signal Transduction | 2019 |
Neutrophilic inflammation in asthma and defective epithelial translational control.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Albuterol; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage; Cell Line, Tumor; Cytoplasm; Epithelial Cells; Epithelium; Female; Forced Expiratory Volume; Humans; Inflammation; Interleukin-17; Interleukin-8; Lung; Male; Methacholine Chloride; Middle Aged; Neutrophils; Randomized Controlled Trials as Topic; Respiratory Function Tests; Smoking; Tumor Necrosis Factor-alpha; Young Adult | 2019 |
Regional airflow obstruction after bronchoconstriction and subsequent bronchodilation in subjects without pulmonary disease.
Topics: Administration, Inhalation; Adult; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Pulmonary Disease, Chronic Obstructive; Young Adult | 2019 |
The effect of astragaloside IV on JAK2-STAT6 signalling pathway in mouse model of ovalbumin-induced asthma.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Female; Gene Expression Regulation; Janus Kinase 2; Leukocytes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Parasympathomimetics; Saponins; Signal Transduction; STAT6 Transcription Factor; Triterpenes | 2019 |
Complement factor C5 inhibition reduces type 2 responses without affecting group 2 innate lymphoid cells in a house dust mite induced murine asthma model.
Topics: Animals; Asthma; Complement C5a; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Immunity, Innate; Lymphocytes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pyroglyphidae; Th2 Cells | 2019 |
Association between eosinophilic airway inflammation and persistent airflow limitation.
Topics: Asthma; Bronchial Provocation Tests; Case-Control Studies; Cell Count; Child; Eosinophil Cationic Protein; Eosinophils; Female; Humans; Inflammation; Male; Methacholine Chloride; Respiratory Function Tests; Sputum; Statistics, Nonparametric | 2013 |
Baseline airway inflammation may be a determinant of the response to ozone exposure in asthmatic patients.
Topics: Adult; Asthma; Atmosphere Exposure Chambers; Female; Forced Expiratory Volume; Glucocorticoids; Humans; Inflammation; Inhalation Exposure; Male; Methacholine Chloride; Neutrophils; Oxidants, Photochemical; Ozone; Sputum | 2013 |
Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma.
Topics: Adolescent; Adult; Animals; Asthma; Disease Models, Animal; Eflornithine; Female; Humans; Hypersensitivity; Inflammation; Lung; Male; Methacholine Chloride; Mice; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Ovalbumin; Polyamines; Spermine; Sputum; Young Adult | 2013 |
Sustained suppression of IL-13 by a vaccine attenuates airway inflammation and remodeling in mice.
Topics: Airway Remodeling; Airway Resistance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Collagen; Cytokines; Elasticity; Female; Interleukin-13; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Vaccination; Vaccines | 2013 |
Interferon-γ promoter is hypermethylated in blood DNA from workers with confirmed diisocyanate asthma.
Topics: Adult; Asthma; DNA; DNA Methylation; Epigenesis, Genetic; Female; Humans; Interferon-gamma; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Occupational Exposure; Promoter Regions, Genetic; Sensitivity and Specificity; Toluene 2,4-Diisocyanate; Young Adult | 2013 |
Influence of β(2)-adrenergic receptor polymorphism on methacholine hyperresponsiveness in asthmatic patients.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cohort Studies; Disease Progression; Female; Humans; Male; Methacholine Chloride; Middle Aged; Polymorphism, Genetic; Receptors, Adrenergic, beta-2; Retrospective Studies | 2013 |
Exhaled breath condensate formate after inhaled allergen provocation in atopic asthmatics in vivo.
Topics: Adult; Aldehyde Oxidoreductases; Allergens; Asthma; Breath Tests; Bronchial Provocation Tests; Bronchoconstrictor Agents; Exhalation; Female; Formates; Humans; Male; Methacholine Chloride; Young Adult | 2013 |
Methacholine-induced airway hyper-reactivity phenotypes.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Phenotype; Prospective Studies; Spirometry | 2013 |
Endogenous osteopontin promotes ozone-induced neutrophil recruitment to the lungs and airway hyperresponsiveness to methacholine.
Topics: Animals; Asthma; Bronchoalveolar Lavage; Bronchoconstrictor Agents; Female; Lung; Lung Injury; Macrophages, Alveolar; Methacholine Chloride; Mice; Mice, Mutant Strains; Neutrophil Infiltration; Neutrophils; Osteopontin; Oxidants, Photochemical; Ozone; Pneumonia | 2013 |
Can an airway challenge test predict respiratory diseases? A population-based international study.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Follow-Up Studies; Humans; Incidence; Male; Methacholine Chloride; Multicenter Studies as Topic; Predictive Value of Tests; Pulmonary Disease, Chronic Obstructive; Rhinitis, Allergic; Rhinitis, Allergic, Perennial; Sensitivity and Specificity; Spirometry | 2014 |
Methacholine challenge testing: improved patient comfort with a 2-tiered protocol.
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Reproducibility of Results; Retrospective Studies; Young Adult | 2013 |
Short-term variability in respiratory impedance and effect of deep breath in asthmatic and healthy subjects with airway smooth muscle activation and unloading.
Topics: Adult; Airway Resistance; Asthma; Bronchi; Electric Impedance; Humans; Methacholine Chloride; Muscle, Smooth | 2013 |
Exhaled nitric oxide as screening tool in subjects with suspected asthma without reversibility.
Topics: Adult; Asthma; Breath Tests; Bronchodilator Agents; Exhalation; Female; Humans; Male; Methacholine Chloride; Nitric Oxide; ROC Curve; Spirometry | 2013 |
Ablation of Arg1 in hematopoietic cells improves respiratory function of lung parenchyma, but not that of larger airways or inflammation in asthmatic mice.
Topics: Airway Resistance; Animals; Arginase; Asthma; Blotting, Western; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Chemokines; Cytokines; Dendritic Cells; Female; Gene Expression Profiling; Hypersensitivity; Immunoenzyme Techniques; Lung; Macrophages; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cells; Ovalbumin; Pneumonia; Real-Time Polymerase Chain Reaction; Respiratory System; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2013 |
Methacholine challenge test results in children are season dependent.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Asthma; Bronchial Provocation Tests; Child; Child, Preschool; Female; Forced Expiratory Volume; Humans; Incidence; Male; Methacholine Chloride; Middle Aged; Respiratory Hypersensitivity; Retrospective Studies; Seasons; Young Adult | 2013 |
A linear parametric approach for analysis of mouse respiratory impedance.
Topics: Algorithms; Animals; Asthma; Diagnosis, Computer-Assisted; Linear Models; Lung; Methacholine Chloride; Mice; Models, Theoretical; Oscillometry; Plethysmography, Impedance; Pressure; Reproducibility of Results; Respiration; Respiratory Function Tests; Signal Processing, Computer-Assisted; Stochastic Processes | 2012 |
Study of methacholine positivity in patients with chronic cough at Masih Daneshvari hospital, Tehran, 2007-2008.
Topics: Adolescent; Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Chronic Disease; Cough; Cross-Sectional Studies; Female; Humans; Iran; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests; Respiratory Sounds; Young Adult | 2013 |
Requirement of apoptosis-inducing kinase 1 for the induction of bronchial asthma following stimulation with ovalbumin.
Topics: Animals; Apoptosis; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Eosinophils; Goblet Cells; Immunoglobulin E; Inflammation; Interleukin-13; Interleukin-5; Lung; MAP Kinase Kinase Kinase 5; MAP Kinase Signaling System; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; Ovalbumin; Tumor Necrosis Factor-alpha | 2013 |
Assessment of airway hyperresponsiveness in mouse models of allergic lung disease using detailed measurements of respiratory mechanics.
Topics: Animals; Asthma; Disease Models, Animal; Humans; Hypersensitivity; Lung; Methacholine Chloride; Mice; Respiratory Mechanics | 2013 |
What are ventilation defects in asthma?
Topics: Adult; Airway Obstruction; Asthma; Bronchi; Bronchial Provocation Tests; Female; Helium; Humans; Lung; Magnetic Resonance Imaging; Male; Methacholine Chloride; Middle Aged; Plethysmography; Pulmonary Ventilation; Spirometry; Tomography, X-Ray Computed; Young Adult | 2014 |
Does the length dependency of airway smooth muscle force contribute to airway hyperresponsiveness?
Topics: Acetylcholine; Airway Remodeling; Asthma; Bronchi; Bronchial Hyperreactivity; Humans; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Potassium; Trachea | 2013 |
Deep inspiration volume and the impaired reversal of bronchoconstriction in asthma.
Topics: Adult; Analysis of Variance; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Female; Forced Expiratory Volume; Humans; Inspiratory Capacity; Male; Methacholine Chloride; Muscarinic Agonists; Young Adult | 2013 |
Different respiratory behaviors disclosed by induced bronchoconstriction in mild asthma patients.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Dyspnea; Electromyography; Female; Humans; Male; Methacholine Chloride; Plethysmography; Pulmonary Ventilation; Tidal Volume; Time Factors; Visual Analog Scale; Young Adult | 2013 |
Useful marker of oscillatory lung function in methacholine challenge test-comparison of reactance and resistance with dose-response slope.
Topics: Adolescent; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Child; Child, Preschool; Diagnosis, Differential; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Oscillometry; ROC Curve; Sensitivity and Specificity; Spirometry | 2014 |
Genetic factors account for most of the variation in serum tryptase--a twin study.
Topics: Adult; Allergens; Asthma; Body Mass Index; Bronchial Hyperreactivity; Dermatitis, Allergic Contact; Female; Humans; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Rhinitis; Skin Tests; Spirometry; Tryptases; Twins, Dizygotic; Twins, Monozygotic; Young Adult | 2013 |
Abr, a negative regulator of Rac, attenuates cockroach allergen-induced asthma in a mouse model.
Topics: Adoptive Transfer; Allergens; Animals; Asthma; CD4-Positive T-Lymphocytes; Cell Movement; Chemokine CCL21; Disease Models, Animal; Eosinophils; GTPase-Activating Proteins; Immunoglobulin E; Interleukin-4; Interleukin-5; Lung; Methacholine Chloride; Mice; Mice, Knockout; rac GTP-Binding Proteins | 2013 |
Distal airway impairment in obese normoreactive women.
Topics: Adult; Asthma; Body Mass Index; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Obesity; Overweight; Vital Capacity | 2013 |
Re-challenge with ovalbumin failed to induce bronchial asthma in mice with eosinophilic bronchitis.
Topics: Administration, Intranasal; Aerosols; Animals; Asthma; Bronchial Hyperreactivity; Bronchitis; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Female; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Pulmonary Eosinophilia | 2013 |
Evaluation of interrupter resistance in methacholine challenge testing in children.
Topics: Airway Resistance; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Sensitivity and Specificity | 2011 |
The CC16 A38G polymorphism is associated with asymptomatic airway hyper-responsiveness and development of late-onset asthma.
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Case-Control Studies; Female; Genetic Association Studies; Genotype; Humans; Inflammation; Male; Methacholine Chloride; Polymorphism, Single Nucleotide; Respiratory Hypersensitivity; Respiratory System; Surveys and Questionnaires; Uteroglobin; Young Adult | 2013 |
Less small airway dysfunction in asymptomatic bronchial hyperresponsiveness than in asthma.
Topics: Adult; Asthma; Asymptomatic Diseases; Body Mass Index; Bronchial Hyperreactivity; Cross-Sectional Studies; Female; Humans; Male; Methacholine Chloride; Middle Aged; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic; Young Adult | 2013 |
Disruption of the bronchodilatory response to deep inspiration in asthma--extrinsic or intrinsic to the airway smooth muscle?
Topics: Asthma; Bronchoconstriction; Female; Humans; Male; Methacholine Chloride; Muscarinic Agonists | 2013 |
Do grandmaternal smoking patterns influence the etiology of childhood asthma?
Topics: Asthma; Bronchial Provocation Tests; Child; Cohort Effect; Family Relations; Female; Humans; Longitudinal Studies; Lung; Male; Methacholine Chloride; Outcome Assessment, Health Care; Pregnancy; Prenatal Exposure Delayed Effects; Respiratory Function Tests; Risk Factors; Sex Factors; Smoking | 2014 |
Alveolar macrophages are critical for the inhibition of allergic asthma by mesenchymal stromal cells.
Topics: Adipose Tissue; Animals; Asthma; Bone Marrow Cells; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Clodronic Acid; Eosinophilia; Female; Genes, Reporter; Graft Survival; Heterografts; Humans; Immunization; Immunosuppression Therapy; Interleukin-10; Lung; Lymphokines; Macrophages, Alveolar; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Methacholine Chloride; Mice; Mice, Inbred BALB C; Organ Specificity; Ovalbumin; Species Specificity; Specific Pathogen-Free Organisms; Th2 Cells; Transduction, Genetic; Umbilical Cord | 2013 |
Comparative study of bronchial hyperresponsiveness to methacholine and mannitol in the initial diagnosis of asthma.
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Humans; Male; Mannitol; Methacholine Chloride; Middle Aged | 2013 |
Prostaglandin E2 elicits greater bronchodilation than salbutamol in mouse intrapulmonary airways in lung slices.
Topics: Adrenergic beta-2 Receptor Agonists; Albuterol; Animals; Asthma; Bronchodilator Agents; Calcium; Dinoprostone; Endothelin-1; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Serotonin | 2014 |
Exhaled breath temperature in asthmatics and controls after eucapnic voluntary hyperventilation and a methacholine challenge test.
Topics: Adult; Asthma; Body Temperature; Breath Tests; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Female; Humans; Hyperventilation; Male; Methacholine Chloride; Nitric Oxide; Oscillometry; Young Adult | 2014 |
B-lymphocytes as key players in chemical-induced asthma.
Topics: Animals; Asthma; B-Lymphocyte Subsets; B7-1 Antigen; B7-2 Antigen; Bronchoconstrictor Agents; CD40 Antigens; Disease Models, Animal; Immunoglobulin E; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, SCID; Toluene 2,4-Diisocyanate | 2013 |
Respiratory syncytial virus and reactive airway disease.
Topics: Adult; Animals; Asthma; Bronchial Provocation Tests; Bronchiolitis, Viral; Child; Humans; Infant; Methacholine Chloride; Mice; Respiratory Hypersensitivity; Respiratory Sounds; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Risk Factors | 2013 |
Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cell Differentiation; Diet; Disease Models, Animal; Female; Lung; Methacholine Chloride; Mice; Mice, Knockout; Muscle, Smooth; Oligonucleotide Array Sequence Analysis; Phenotype; Pregnancy; Signal Transduction; Tretinoin; Vitamin A; Vitamin A Deficiency | 2014 |
KCNQ (Kv7) potassium channel activators as bronchodilators: combination with a β2-adrenergic agonist enhances relaxation of rat airways.
Topics: Acetylcholine; Adrenergic beta-2 Receptor Agonists; Animals; Anthracenes; Asthma; Bronchi; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Carbamates; Ethanolamines; Formoterol Fumarate; KCNQ Potassium Channels; Keratolytic Agents; Male; Membrane Transport Modulators; Methacholine Chloride; Myocytes, Smooth Muscle; Organometallic Compounds; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Sulfonamides | 2014 |
What makes a difference in exercise-induced bronchoconstriction: an 8 year retrospective analysis.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Exercise; Exercise Test; Female; Humans; Humidity; Male; Methacholine Chloride; Retrospective Studies; Temperature; Young Adult | 2014 |
Reduced forced expiratory flow but not increased exhaled nitric oxide or airway responsiveness to methacholine characterises paediatric sickle cell airway disease.
Topics: Adolescent; Airway Obstruction; Anemia, Sickle Cell; Asthma; Breath Tests; Case-Control Studies; Child; Eosinophils; Female; Forced Expiratory Flow Rates; Humans; Hypersensitivity; Immunoglobulin E; Leukocyte Count; Lung; Male; Methacholine Chloride; Nitric Oxide; Spirometry; Statistics, Nonparametric | 2014 |
Naringenin inhibits allergen‑induced airway remodeling in a murine model of asthma.
Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Differentiation; Chronic Disease; Cytokines; Disease Models, Animal; Female; Fibrosis; Flavanones; Immunoglobulin E; Inflammation; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucus; Ovalbumin; Th2 Cells | 2014 |
The complex relationship between inflammation and lung function in severe asthma.
Topics: Adolescent; Adult; Age of Onset; Aged; Aged, 80 and over; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Child; Cytokines; Female; Humans; Inflammation; Lung; Male; Methacholine Chloride; Mice; Mice, Transgenic; Middle Aged; Severity of Illness Index; Sputum | 2014 |
ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma.
Topics: Activating Transcription Factor 6; Airway Remodeling; Allergens; Animals; Antibody Specificity; Asthma; Bronchial Hyperreactivity; Chemokines, CC; Chemokines, CXC; Cytokines; Disease Models, Animal; eIF-2 Kinase; Eosinophils; Gene Expression; Gene Order; Gene Targeting; Humans; Immunoglobulin E; Inflammation; Lung; Membrane Proteins; Methacholine Chloride; Mice; Mice, Transgenic; Ovalbumin; Th2 Cells; Transgenes; Unfolded Protein Response | 2014 |
Are asthmatic patients prone to bone loss?
Topics: Asthma; Body Mass Index; Bone Density; Bone Resorption; Bronchial Provocation Tests; Cross-Sectional Studies; Female; Femur; Humans; Lumbar Vertebrae; Male; Methacholine Chloride; Middle Aged; Osteoporosis; Radiography; Retrospective Studies | 2014 |
Potential role of pentosidine on susceptibility to small airway closure in elderly and smoking asthma.
Topics: Adult; Aged; Aging; Arginine; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Case-Control Studies; Female; Forced Expiratory Volume; Humans; Lysine; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests; Smoking; Sputum; Vital Capacity; Young Adult | 2014 |
Pharmacogenomics: novel loci identification via integrating gene differential analysis and eQTL analysis.
Topics: Asthma; Black or African American; Cell Line; Child; Child, Preschool; Dexamethasone; Gene Expression Regulation; Humans; Methacholine Chloride; Polymorphism, Single Nucleotide; Quantitative Trait Loci; White People | 2014 |
Adenosine dry powder inhalation for bronchial challenge testing, part 2: proof of concept in asthmatic subjects.
Topics: Adenosine; Adenosine Monophosphate; Administration, Inhalation; Adult; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dry Powder Inhalers; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Pilot Projects; Powders | 2014 |
Maternal stress during pregnancy increases neonatal allergy susceptibility: role of glucocorticoids.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Corticosterone; Disease Susceptibility; Female; Glucocorticoids; Methacholine Chloride; Metyrapone; Mice; Mice, Inbred BALB C; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Restraint, Physical; Stress, Psychological | 2014 |
Relationship between Methacholine Challenge Testing and exhaled nitric oxide in adult patients with suspected bronchial asthma.
Topics: Adult; Age Factors; Asthma; Biomarkers; Breath Tests; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Disease Progression; Exhalation; Female; Humans; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Predictive Value of Tests; Prognosis; Severity of Illness Index; Young Adult | 2014 |
Assessing direct and indirect airway hyperresponsiveness in children using impulse oscillometry.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchopulmonary Dysplasia; Child; Child, Preschool; Exercise; Female; Forced Expiratory Volume; Humans; Lung; Male; Mannitol; Methacholine Chloride; Oscillometry | 2014 |
Characterization of exhaled particles from the human lungs in airway obstruction.
Topics: Adult; Aerosols; Aged; Asthma; Biomarkers; Breath Tests; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Exhalation; Female; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Particle Size; Predictive Value of Tests; Prospective Studies; Pulmonary Disease, Chronic Obstructive; Reproducibility of Results; Smoking; Young Adult | 2015 |
Diagnostic properties of the methacholine and mannitol bronchial challenge tests: a comparison study.
Topics: Adult; Asthma; Bronchial Provocation Tests; Case-Control Studies; Dose-Response Relationship, Drug; Female; Humans; Lung; Male; Mannitol; Methacholine Chloride; Middle Aged; Prospective Studies; Republic of Korea; ROC Curve; Sensitivity and Specificity | 2014 |
Effects of sex hormones on bronchial reactivity during the menstrual cycle.
Topics: Adult; Asthma; Bronchial Provocation Tests; Carbon Monoxide; Cyclic AMP; Estradiol; Female; Follicle Stimulating Hormone; Follicular Phase; Forced Expiratory Volume; Humans; Luteal Phase; Luteinizing Hormone; Methacholine Chloride; Phosphoric Diester Hydrolases; Progesterone; Prolactin; Pulmonary Diffusing Capacity; Sputum; Testosterone; Young Adult | 2014 |
Comprehensive multiplexed protein quantitation delineates eosinophilic and neutrophilic experimental asthma.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Biomarkers; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Female; Hydrocortisone; Inflammation; Inflammation Mediators; Leukocyte Count; Lipopolysaccharides; Mass Spectrometry; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; Phenotype; Protein Array Analysis; Proteome; Respiratory Mechanics | 2014 |
Comprehensive efficacy of omalizumab for severe refractory asthma: a time-series observational study.
Topics: Adult; Anti-Asthmatic Agents; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Asthma; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Omalizumab; Peak Expiratory Flow Rate; Prospective Studies; Quality of Life; Respiratory Function Tests; Sputum; Surveys and Questionnaires; Treatment Outcome | 2014 |
Relationship between the baseline alveolar volume-to-total lung capacity ratio and airway responsiveness.
Topics: Adult; Aged; Airway Remodeling; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cohort Studies; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Pulmonary Diffusing Capacity; Spirometry; Total Lung Capacity | 2014 |
Effects of cigarette smoke on methacholine- and AMP-induced air trapping in asthmatics.
Topics: Adenosine Monophosphate; Adult; Asthma; Breath Tests; Bronchoconstrictor Agents; Female; Humans; Male; Methacholine Chloride; Middle Aged; Nicotiana; Nitric Oxide; Pulmonary Disease, Chronic Obstructive; Smoke; Smoking; Vital Capacity | 2015 |
Pulmonary vascular volumes and airways obstruction in SCD patients.
Topics: Anemia, Sickle Cell; Asthma; Female; Forced Expiratory Flow Rates; Humans; Immunoglobulin E; Male; Methacholine Chloride; Nitric Oxide | 2014 |
The preventive effects of natural adjuvants, G2 and G2F on tracheal responsiveness and serum IL-4 and IFN-γ (th1/th2 balance) in sensitized guinea pigs.
Topics: Adjuvants, Immunologic; Animals; Asthma; Bronchoconstrictor Agents; Female; Guinea Pigs; Immunization; Interferon-alpha; Interleukin-4; Male; Methacholine Chloride; Ovalbumin; Plant Oils; Pneumonia; Reproducibility of Results; Th1-Th2 Balance; Trachea | 2014 |
Letter to the editor in reply to 'pulmonary vascular volumes and airways obstruction in SCD patients'.
Topics: Anemia, Sickle Cell; Asthma; Female; Forced Expiratory Flow Rates; Humans; Immunoglobulin E; Male; Methacholine Chloride; Nitric Oxide | 2014 |
Effect of lowering methacholine challenge test cutoff in children.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Child, Preschool; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Retrospective Studies; Spirometry | 2014 |
Sputum adiponectin as a marker for western red cedar asthma.
Topics: Adiponectin; Adult; Antigens, Plant; Asthma; Body Mass Index; Bronchial Provocation Tests; Dust; Eosinophilia; Forced Expiratory Volume; Humans; Lignans; Male; Methacholine Chloride; Middle Aged; Naphthols; Occupational Diseases; Occupational Exposure; Sputum; Thuja; Young Adult | 2014 |
Angiogenesis and airway reactivity in asthmatic Brown Norway rats.
Topics: Airway Resistance; Analysis of Variance; Animals; Asthma; Bronchial Arteries; Bronchial Hyperreactivity; Disease Models, Animal; DNA Primers; Fluorocarbons; Lung; Magnetic Resonance Imaging; Methacholine Chloride; Nanoparticles; Neovascularization, Pathologic; Pyroglyphidae; Rats; Real-Time Polymerase Chain Reaction; Silicone Elastomers; Time Factors | 2015 |
Effects of inhaled L-arginine administration in a murine model of acute asthma.
Topics: Acute Disease; Animals; Arginine; Asthma; Bronchoconstrictor Agents; Bronchodilator Agents; Budesonide; Disease Models, Animal; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nitric Oxide; Time Factors | 2014 |
Tracheal section is an independent predictor of asthma in patients with nasal polyposis.
Topics: Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Multivariate Analysis; Nasal Polyps; Predictive Value of Tests; Prospective Studies; Trachea | 2014 |
Predictors of airway hyperresponsiveness in elite athletes.
Topics: Adult; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchial Provocation Tests; C-Reactive Protein; Cross-Sectional Studies; Female; Humans; Interleukin-6; Interleukin-8; Male; Mannitol; Methacholine Chloride; Physical Education and Training; Spirometry; Sports; Tumor Necrosis Factor-alpha; Young Adult | 2015 |
The orl rat is more responsive to methacholine challenge than wild type.
Topics: Administration, Inhalation; Albuterol; Animals; Anti-Asthmatic Agents; Asthma; Bronchoconstrictor Agents; Cryptorchidism; Disease Models, Animal; Dose-Response Relationship, Drug; Interleukin-4; Interleukin-6; Lung; Male; Methacholine Chloride; Rats, Long-Evans; Tumor Necrosis Factor-alpha | 2014 |
Vitamin D supplementation blocks pulmonary structural and functional changes in a rat model of perinatal vitamin D deficiency.
Topics: Alkaline Phosphatase; Animals; Asthma; Calcium; Cholecalciferol; Dietary Supplements; Epithelial-Mesenchymal Transition; Female; Lung; Methacholine Chloride; Pregnancy; Rats; Rats, Sprague-Dawley; Respiratory Function Tests; Vitamin D; Vitamin D Deficiency | 2014 |
The correlation between the bronchial hyperresponsiveness to methacholine and asthma like symptoms by GINA questionnaires for the diagnosis of asthma.
Topics: Adult; Aged; Aged, 80 and over; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dyspnea; Female; Humans; Male; Methacholine Chloride; Middle Aged; Respiratory Sounds; Sensitivity and Specificity; Surveys and Questionnaires; Young Adult | 2014 |
Evaluation of high-sensitivity serum CRP levels compared to markers of airway inflammation and allergy as predictors of methacholine bronchial hyper-responsiveness in children.
Topics: Adolescent; Age Factors; Area Under Curve; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; C-Reactive Protein; Chi-Square Distribution; Child; Diagnosis, Differential; Eosinophils; Female; Humans; Immunoglobulin E; Inflammation Mediators; Leukocyte Count; Logistic Models; Lung; Male; Methacholine Chloride; Nitric Oxide; Odds Ratio; Predictive Value of Tests; Prospective Studies; ROC Curve | 2015 |
Effects of immunomodulatory supplementation with Lactobacillus rhamnosus on airway inflammation in a mouse asthma model.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Immunoglobulin E; Lacticaseibacillus rhamnosus; Lung; Matrix Metalloproteinase 9; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Probiotics | 2016 |
Effect of ingested H₁ antihistamines on methacholine challenge.
Topics: Asthma; Bronchial Provocation Tests; Histamine H1 Antagonists; Humans; Methacholine Chloride; Practice Guidelines as Topic | 2015 |
The gain of smooth muscle's contractile capacity induced by tone on in vivo airway responsiveness in mice.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Asthma; Bronchodilator Agents; Female; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth; Respiratory Hypersensitivity; Respiratory System | 2015 |
Thymic stromal lymphopoietin and IL-33 modulate migration of hematopoietic progenitor cells in patients with allergic asthma.
Topics: Administration, Inhalation; Adult; Allergens; Asthma; Cell Movement; Chemokine CXCL12; Cytokines; Eosinophils; Forced Expiratory Volume; Gene Expression Regulation; Hematopoietic Stem Cells; Humans; Immunity, Innate; Interleukin-1 Receptor-Like 1 Protein; Interleukin-13; Interleukin-13 Receptor alpha1 Subunit; Interleukin-33; Interleukin-5; Interleukin-7 Receptor alpha Subunit; Interleukins; Male; Methacholine Chloride; Middle Aged; Primary Cell Culture; Receptors, Cell Surface; Receptors, Cytokine; Sputum; Thymic Stromal Lymphopoietin | 2015 |
The polymeric mucin Muc5ac is required for allergic airway hyperreactivity.
Topics: Allergens; Animals; Aspergillus oryzae; Asthma; Bronchial Hyperreactivity; Female; Immunohistochemistry; Inflammation; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Mucin 5AC; Mucus; Ovalbumin; Species Specificity | 2015 |
Human trachealis and main bronchi smooth muscle are normoresponsive in asthma.
Topics: Adult; Aged; Asthma; Bronchi; Bronchial Hyperreactivity; Female; Humans; Male; Methacholine Chloride; Middle Aged; Muscle Contraction; Muscle, Smooth; Trachea; Young Adult | 2015 |
Serum periostin levels correlate with airway hyper-responsiveness to methacholine and mannitol in children with asthma.
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Cell Adhesion Molecules; Child; Female; Forced Expiratory Volume; Humans; Male; Mannitol; Methacholine Chloride; Respiratory Hypersensitivity | 2015 |
Airway hyper-responsiveness and small airway function in children with well-controlled asthma.
Topics: Asthma; Asymptomatic Diseases; Bronchioles; Child; Humans; Methacholine Chloride; Oscillometry; Respiratory Hypersensitivity; Spirometry; Vital Capacity | 2015 |
Hyaluronan mediates airway hyperresponsiveness in oxidative lung injury.
Topics: Alpha-Globulins; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Chlorine; Enzyme Activation; Extracellular Matrix; Hyaluronic Acid; Inflammation; Lung Injury; Membrane Potentials; Methacholine Chloride; Mice; Mice, Inbred C57BL; Muscle Contraction; Myocytes, Smooth Muscle; Oxidative Stress; Patch-Clamp Techniques; Reactive Oxygen Species; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Trachea | 2015 |
Methacholine challenge. PD20 versus PC20.
Topics: Asthma; Bronchial Hyperreactivity; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride | 2015 |
Exhaled Nitric Oxide and Airway Hyperresponsiveness to Adenosine 5'-monophosphate and Methacholine in Children with Asthma.
Topics: Adenosine Monophosphate; Adolescent; Asthma; Breath Tests; Bronchial Provocation Tests; Child; Eosinophil Cationic Protein; Eosinophils; Female; Humans; Immunoglobulin E; Inflammation; Linear Models; Male; Methacholine Chloride; Nitric Oxide | 2015 |
Analysis of the contributing factors to airway hyperresponsiveness by a forced oscillation technique in patients with asthma.
Topics: Adult; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Case-Control Studies; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Predictive Value of Tests; Risk Factors; Spirometry; Vital Capacity | 2014 |
Bronchial Reactivity, Inflammatory and Allergic Parameters, and Vitamin D Levels in Children With Asthma.
Topics: Adolescent; Asthma; Biomarkers; Bronchial Provocation Tests; Bronchoconstrictor Agents; C-Reactive Protein; Child; Eosinophils; Female; Humans; Hypersensitivity; Immunoglobulin E; Inflammation Mediators; Leukocyte Count; Male; Methacholine Chloride; Nitric Oxide; Pulmonary Elimination; Spirometry; Vitamin D | 2015 |
Chronic neurokinin-1 receptor antagonism fails to ameliorate clinical signs, airway hyper-responsiveness or airway eosinophilia in an experimental model of feline asthma.
Topics: Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cat Diseases; Cats; Disease Models, Animal; Eosinophilia; Methacholine Chloride; Neurokinin-1 Receptor Antagonists; Prospective Studies; Random Allocation; Receptors, Neurokinin-1 | 2016 |
Plasma arginine metabolites reflect airway dysfunction in a murine model of allergic airway inflammation.
Topics: Animals; Arginase; Arginine; Asthma; Bronchoconstrictor Agents; Citrulline; Enzyme Inhibitors; Female; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase; Ornithine; Ovalbumin; Respiratory System | 2015 |
Association between asthma control test, pulmonary function tests and non-specific bronchial hyperresponsiveness in assessing the level of asthma control.
Topics: Adolescent; Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests; Young Adult | 2015 |
Vitamin E Isoform γ-Tocotrienol Downregulates House Dust Mite-Induced Asthma.
Topics: Allergens; alpha-Tocopherol; Animals; Anti-Inflammatory Agents; Antioxidants; Asthma; Bronchoalveolar Lavage Fluid; Chromans; Cytokines; Dermatophagoides pteronyssinus; Disease Models, Animal; Eosinophils; Female; Gene Expression; Immunoglobulin E; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Prednisolone; Reactive Oxygen Species; Vitamin E | 2015 |
Properdin Contributes to Allergic Airway Inflammation through Local C3a Generation.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Complement C3a; Eosinophils; Humans; Inflammation; Leukocyte Count; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Properdin; Th17 Cells; Th2 Cells | 2015 |
Usefulness of impulse oscillometry for the assessment of airway hyperresponsiveness in mild-to-moderate adult asthma.
Topics: Adrenal Cortex Hormones; Adult; Aged; Airway Resistance; Area Under Curve; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Double-Blind Method; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Middle Aged; Oscillometry; Randomized Controlled Trials as Topic; Retrospective Studies; Spirometry; Young Adult | 2015 |
Asthma-associated comorbidities in children with and without secondhand smoke exposure.
Topics: Adolescent; Asthma; Body Mass Index; Case-Control Studies; Child; Child, Preschool; Comorbidity; Exhalation; Female; Forced Expiratory Volume; Hospitalization; Humans; Influenza Vaccines; Inhalation Exposure; Male; Methacholine Chloride; Nitric Oxide; Obesity; Retrospective Studies; Risk Factors; Severity of Illness Index; Spirometry; Tobacco Smoke Pollution; Vaccination | 2015 |
Allergen extract vs. component sensitization and airway inflammation, responsiveness and new-onset respiratory disease.
Topics: Adult; Allergens; Animals; Asthma; Biomarkers; Bronchial Provocation Tests; Cats; Exhalation; Female; Follow-Up Studies; Health Surveys; Humans; Immunization; Immunoglobulin E; Inflammation; Inhalation Exposure; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Respiratory Tract Diseases; Rhinitis; Sweden | 2016 |
Exhaled nitric oxide as a better diagnostic indicator for evaluating wheeze and airway hyperresponsiveness in preschool children.
Topics: Asthma; Breath Tests; Bronchial Provocation Tests; Child; Child, Preschool; Cross-Sectional Studies; Female; Humans; Male; Methacholine Chloride; Nitric Oxide; Respiratory Function Tests; Respiratory Hypersensitivity; Respiratory Sounds | 2015 |
Greater parallel heterogeneity of airway narrowing and airway closure in asthma measured by high-resolution CT.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Female; Humans; Image Interpretation, Computer-Assisted; Male; Methacholine Chloride; Respiration; Supine Position; Tomography, X-Ray Computed; Young Adult | 2015 |
Do asthma patients with panic disorder really have worse asthma? A comparison of physiological and psychological responses to a methacholine challenge.
Topics: Adult; Aged; Anxiety; Asthma; Blood Pressure; Bronchial Provocation Tests; Dyspnea; Female; Forced Expiratory Volume; Heart Rate; Humans; Male; Methacholine Chloride; Middle Aged; Panic Disorder; Severity of Illness Index | 2015 |
Rosiglitazone elicits in vitro relaxation in airways and precision cut lung slices from a mouse model of chronic allergic airways disease.
Topics: Adrenergic beta-Agonists; Animals; Anti-Asthmatic Agents; Asthma; Drug Evaluation, Preclinical; Female; Guinea Pigs; Lung; Male; Methacholine Chloride; Mice, Inbred BALB C; Muscle Relaxation; Muscle, Smooth; Rosiglitazone; Thiazolidinediones; Trachea | 2015 |
Serum club cell protein 16 is associated with asymptomatic airway responsiveness in adults: Findings from the French epidemiological study on the genetics and environment of asthma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchial Provocation Tests; Case-Control Studies; Female; Forced Expiratory Volume; France; Humans; Male; Methacholine Chloride; Middle Aged; Uteroglobin; Vital Capacity; Young Adult | 2015 |
Bronchoconstriction induced by inhaled methacholine delays desflurane uptake and elimination in a piglet model.
Topics: Administration, Inhalation; Anesthetics, Inhalation; Animals; Asthma; Blood Chemical Analysis; Bronchoconstriction; Bronchoconstrictor Agents; Desflurane; Hemodynamics; Isoflurane; Mass Spectrometry; Methacholine Chloride; Prospective Studies; Respiration; Sus scrofa | 2016 |
Peripheral Airway Smooth Muscle, but Not the Trachealis, Is Hypercontractile in an Equine Model of Asthma.
Topics: Actin Cytoskeleton; Animals; Asthma; Blotting, Western; Ca(2+) Mg(2+)-ATPase; Contractile Proteins; Disease Models, Animal; Female; Horse Diseases; Horses; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Myofibrils; Myosin Heavy Chains; Myosins; Respiratory Mechanics; Trachea | 2016 |
High levels of physical activity are associated with poorer asthma control in young females but not in males.
Topics: Adolescent; Adult; Asthma; Breath Tests; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Female; Humans; Male; Methacholine Chloride; Motor Activity; Nitric Oxide; Sex Factors; Spirometry; Surveys and Questionnaires; Young Adult | 2016 |
The impact of food allergens on airway responsiveness in schoolchildren with asthma: A DBPCFC study.
Topics: Administration, Inhalation; Adolescent; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Double-Blind Method; Female; Food Hypersensitivity; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Spirometry | 2016 |
Regional Ventilation and Aerosol Deposition with Helium-Oxygen in Bronchoconstricted Asthmatic Lungs.
Topics: Administration, Inhalation; Adolescent; Aerosols; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Drug Carriers; Female; Gases; Helium; Humans; Imaging, Three-Dimensional; Inhalation; Isotonic Solutions; Lung; Male; Methacholine Chloride; Models, Biological; Nebulizers and Vaporizers; Oxygen; Positron Emission Tomography Computed Tomography; Pulmonary Ventilation; Sodium Chloride; Tissue Distribution; Young Adult | 2016 |
Neonatal pneumococcal colonisation caused by Influenza A infection alters lung function in adult mice.
Topics: Airway Resistance; Animals; Animals, Newborn; Asthma; Bronchoconstrictor Agents; Coinfection; Female; Histocytochemistry; Influenza A virus; Lung; Methacholine Chloride; Mice, Inbred C57BL; Orthomyxoviridae Infections; Pneumococcal Infections; Respiratory Function Tests; Streptococcus pneumoniae | 2016 |
Reduction in peripheral blood eosinophil counts after bronchial thermoplasty.
Topics: Anti-Asthmatic Agents; Asthma; Bronchi; Bronchial Thermoplasty; Drug Administration Schedule; Eosinophils; Humans; Leukocyte Count; Methacholine Chloride; Muscle, Smooth; Prednisolone; Retrospective Studies; Severity of Illness Index | 2016 |
[Effects and significance of methacholine bronchial provocation tests and salbutamol bronchial dilation test on measurements of fractional exhaled nitric oxide in patients with asthma].
Topics: Albuterol; Asthma; Breath Tests; Bronchial Provocation Tests; Exhalation; Humans; Methacholine Chloride; Nitric Oxide; Prospective Studies; Spirometry | 2016 |
Persisting long term benefits of smoking abstinence and reduction in asthmatic smokers who have switched to electronic cigarettes.
Topics: Adult; Asthma; Disease Progression; Electronic Nicotine Delivery Systems; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Respiratory Function Tests; Smoking; Surveys and Questionnaires; Time Factors; Vital Capacity | 2016 |
Weight Loss Decreases Inherent and Allergic Methacholine Hyperresponsiveness in Mouse Models of Diet-Induced Obese Asthma.
Topics: Animals; Asthma; Bacteria; Bariatric Surgery; Bronchial Hyperreactivity; Cytokines; Diet; Disease Models, Animal; Hypersensitivity; Inflammation Mediators; Intestines; Male; Methacholine Chloride; Mice, Inbred C57BL; Mice, Obese; Obesity; Weight Loss | 2016 |
Bronchodilator response following methacholine-induced bronchoconstriction predicts acute asthma exacerbations.
Topics: Administration, Inhalation; Aged; Asthma; Boston; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Child; Disease Progression; Female; Forced Expiratory Volume; Humans; Logistic Models; Male; Methacholine Chloride; Prospective Studies; Republic of Korea | 2016 |
Cost-Effectiveness Analysis of 3 Methacholine Challenge Tests: Importance of Simplified Protocols.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cost-Benefit Analysis; Female; Humans; Male; Methacholine Chloride; Middle Aged | 2016 |
Excessive variability in the performance and interpretation of the metacholine bronchial challenge test.
Topics: Allergy and Immunology; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Hospital Departments; Humans; Methacholine Chloride; Pulmonary Medicine; Reference Values; Reproducibility of Results; Spain; Surveys and Questionnaires | 2016 |
Bronchoconstriction-triggered cough in atopic cough: A retrospective study.
Topics: Adult; Aged; Asthma; Bronchoconstriction; Chronic Disease; Cough; Female; Humans; Male; Methacholine Chloride; Middle Aged; Retrospective Studies | 2016 |
Reversion of methacholine induced bronchoconstriction with inhaled diazepam in patients with asthma.
Topics: Administration, Inhalation; Adult; Anthropometry; Asthma; Benzodiazepines; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Diazepam; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Receptors, GABA-A; Reference Values; Reproducibility of Results; Time Factors; Vital Capacity | 2016 |
Plethysmography Phenotype QTL in Mice Before and After Allergen Sensitization and Challenge.
Topics: Allergens; Animals; Asthma; Disease Models, Animal; Gene-Environment Interaction; Humans; Hypersensitivity; Immunization; Lung; Methacholine Chloride; Mice; Plethysmography; Pyroglyphidae; Quantitative Trait Loci | 2016 |
A novel peptide ADAM8 inhibitor attenuates bronchial hyperresponsiveness and Th2 cytokine mediated inflammation of murine asthmatic models.
Topics: ADAM Proteins; Animals; Antigens, CD; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Disease Models, Animal; Eosinophils; Gene Expression Regulation; Inflammation; Membrane Proteins; Methacholine Chloride; Mice, Inbred BALB C; Mice, Knockout; Peptides, Cyclic; Receptors, IgE; RNA, Messenger; Solubility; Th2 Cells | 2016 |
Misdiagnosis of asthma in schoolchildren.
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Cohort Studies; Diagnostic Errors; Female; Humans; Male; Methacholine Chloride; Sensitivity and Specificity; Skin Tests; Spirometry | 2017 |
Evaluation of exhaled nitric oxide's ability to predict methacholine challenge in adults with nonobstructive spirometry.
Topics: Adult; Aged; Asthma; Breath Tests; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cough; Dyspnea; Exhalation; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Predictive Value of Tests; Retrospective Studies; ROC Curve; Spirometry | 2016 |
Comparison of diagnostic validity of mannitol and methacholine challenges and relationship to clinical status and airway inflammation in steroid-naïve asthmatic patients.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Cross-Sectional Studies; Female; Humans; Inflammation; Inflammation Mediators; Male; Mannitol; Methacholine Chloride; Middle Aged; Nitric Oxide; Respiratory Function Tests; Sensitivity and Specificity; Severity of Illness Index; Skin Tests | 2017 |
Indoleamine 2,3-Dioxygenase Is Not a Pivotal Regulator Responsible for Suppressing Allergic Airway Inflammation through Adipose-Derived Stem Cells.
Topics: Adipose Tissue; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell- and Tissue-Based Therapy; Cells, Cultured; Eosinophils; Female; Goblet Cells; Hyperplasia; Immunoglobulin E; Immunoglobulin G; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Interleukin-10; Interleukin-13; Interleukin-4; Interleukin-5; Lymphocyte Count; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; T-Lymphocytes, Regulatory; Transforming Growth Factor beta | 2016 |
Diagnostic accuracy of methacholine challenge tests assessing airway hyperreactivity in asthmatic patients - a multifunctional approach.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Area Under Curve; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Child; Databases, Factual; Dose-Response Relationship, Drug; Female; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Plethysmography, Whole Body; Predictive Value of Tests; Reproducibility of Results; Retrospective Studies; ROC Curve; Spirometry; Switzerland; Young Adult | 2016 |
Optimization of substituted imidazobenzodiazepines as novel asthma treatments.
Topics: Animals; Asthma; Benzodiazepines; Constriction, Pathologic; Deuterium; Drug Evaluation, Preclinical; Drug Stability; Guinea Pigs; Methacholine Chloride; Mice; Receptors, GABA-A; Respiratory Hypersensitivity; Structure-Activity Relationship; Sulfuric Acid Esters; Trachea | 2017 |
Glucagon-like peptide-1 receptor expression on human eosinophils and its regulation of eosinophil activation.
Topics: Adult; Allergens; Asthma; Bronchial Provocation Tests; Eosinophils; Female; Gene Expression; Glucagon-Like Peptide-1 Receptor; Humans; Immunomodulation; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests; Young Adult | 2017 |
The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma.
Topics: Administration, Inhalation; Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Interleukin-17; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Mycobacterium phlei; Neutrophils; Ovalbumin; Receptors, Interleukin; Vaccines, Inactivated | 2017 |
Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide in children with asthma.
Topics: Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Asthma; Australia; Breath Tests; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Child, Preschool; Eosinophils; Female; Humans; Immunoglobulin E; Male; Mannitol; Methacholine Chloride; Nitric Oxide; Spirometry | 2017 |
Heterogeneity of airway wall dimensions in humans: a critical determinant of lung function in asthmatics and nonasthmatics.
Topics: Adolescent; Adult; Asthma; Biomechanical Phenomena; Child; Child, Preschool; Demography; Electric Impedance; Female; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests; Young Adult | 2017 |
Detection of smoothly distributed spatial outliers, with applications to identifying the distribution of parenchymal hyperinflation following an airway challenge in asthmatics.
Topics: Adult; Asthma; Biostatistics; Bronchial Hyperreactivity; Bronchial Provocation Tests; Case-Control Studies; Computer Simulation; Female; Humans; Likelihood Functions; Male; Methacholine Chloride; Middle Aged; Models, Statistical; Normal Distribution; Respiratory Function Tests; Tomography, X-Ray Computed | 2017 |
Exhaled nitric oxide or FEF
Topics: Asthma; Breath Tests; Child; Exhalation; Female; Humans; Male; Methacholine Chloride; Nitric Oxide; Respiratory Tract Diseases; Uncertainty | 2017 |
Exhaled nitric oxide's ability to predict methacholine challenge: A matter of definition.
Topics: Asthma; Breath Tests; Exhalation; Humans; Methacholine Chloride; Nitric Oxide; Retrospective Studies | 2017 |
Oral administration of Lactobacillus paracasei L9 attenuates PM2.5-induced enhancement of airway hyperresponsiveness and allergic airway response in murine model of asthma.
Topics: Administration, Oral; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Eosinophils; Female; Hypersensitivity; Immunotherapy; Lacticaseibacillus paracasei; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; Particulate Matter; Probiotics; Th1 Cells; Th2 Cells | 2017 |
Different cutoff values of methacholine bronchial provocation test depending on age in children with asthma.
Topics: Adolescent; Age Factors; Asthma; Bronchial Provocation Tests; Child; Female; Humans; Male; Methacholine Chloride; Muscarinic Agonists | 2017 |
Peri-adolescent asthma symptoms cause adult anxiety-related behavior and neurobiological processes in mice.
Topics: Age Factors; Animals; Anxiety; Asthma; Behavior, Animal; Disease Models, Animal; Female; Gene Expression; Hippocampus; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Muscarinic Agonists; Pyroglyphidae; Sex Factors | 2017 |
Immunologic regulatory effects of human umbilical cord blood-derived mesenchymal stem cells in a murine ovalbumin asthma model.
Topics: Allergens; Animals; Asthma; Cytokines; Disease Models, Animal; Female; Fetal Blood; Humans; Immunization; Immunoglobulin E; Immunomodulation; Inflammation Mediators; Lymph Nodes; Mesenchymal Stem Cells; Methacholine Chloride; Mice; Ovalbumin; Spleen; T-Lymphocyte Subsets | 2017 |
Workplace-specific challenges as a contribution to the diagnosis of occupational asthma.
Topics: Adult; Asthma; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Occupational Exposure; Retrospective Studies; Spirometry; Time Factors; Treatment Outcome; Workplace | 2008 |
Magnitude of late asthmatic response to allergen in relation to baseline and allergen-induced sputum eosinophilia in mild asthmatic patients.
Topics: Adolescent; Adult; Allergens; Asthma; Bronchial Provocation Tests; Cell Count; Chemotaxis, Leukocyte; Eosinophil Cationic Protein; Eosinophilia; Eosinophils; Female; Forced Expiratory Volume; Humans; Leukocyte Count; Macrophages, Alveolar; Male; Methacholine Chloride; Neutrophils; Sputum | 2008 |
Airway responsiveness and inflammation in adolescent elite swimmers.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Sectional Studies; Female; Humans; Inflammation; Lung; Male; Methacholine Chloride; Nitric Oxide; Respiratory Function Tests; Spirometry; Swimming | 2008 |
Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation.
Topics: Airway Obstruction; Aminocaproates; Animals; Arginase; Asthma; Boron Compounds; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage; Guinea Pigs; Methacholine Chloride; Models, Animal; Nitric Oxide | 2008 |
Can bronchodilator response predict bronchial response to methacholine in preschool coughers?
Topics: Airway Resistance; Asthma; Bronchi; Bronchoconstriction; Bronchodilator Agents; Child; Child, Preschool; Cough; Female; Humans; Male; Methacholine Chloride; Severity of Illness Index; Time Factors | 2008 |
Physiology of the small airways: A gender difference?
Topics: Adolescent; Adult; Asthma; Breath Tests; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Humans; Male; Methacholine Chloride; Middle Aged; Multivariate Analysis; Nitric Oxide; Nitric Oxide Synthase Type III; Pulmonary Alveoli; Sex Factors; Statistics, Nonparametric; Tomography, X-Ray Computed | 2008 |
Dividing the FEV1 into its component parts.
Topics: Asthma; Bronchodilator Agents; Forced Expiratory Volume; Humans; Methacholine Chloride; Vital Capacity | 2008 |
Increased airway closure is a determinant of airway hyperresponsiveness.
Topics: Adult; Asthma; Body Mass Index; Bronchi; Bronchoconstriction; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Obesity; Spirometry | 2008 |
Methacholine challenge in children with sickle cell disease: a case series.
Topics: Adolescent; Anemia, Sickle Cell; Asthma; Child; Child, Preschool; Female; Humans; Male; Methacholine Chloride | 2008 |
Airway responses to eucapnic hyperpnea, exercise, and methacholine in elite swimmers.
Topics: Adolescent; Airway Resistance; Asthma; Bronchi; Bronchoconstrictor Agents; Exercise; Female; Humans; Hyperventilation; Methacholine Chloride; Swimming; Young Adult | 2008 |
Time course of airway remodelling after an acute chlorine gas exposure in mice.
Topics: Animals; Apoptosis; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Proliferation; Chlorine; Disease Models, Animal; Gases; Goblet Cells; Lung; Male; Methacholine Chloride; Mice; Proliferating Cell Nuclear Antigen; Toxicity Tests, Acute | 2008 |
No effect of metformin on the innate airway hyperresponsiveness and increased responses to ozone observed in obese mice.
Topics: Administration, Oral; Animals; Asthma; Blood Glucose; Body Weight; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Chemokines; Diabetes Mellitus; Disease Models, Animal; Female; Hypoglycemic Agents; Inflammation Mediators; Metformin; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Obese; Neutrophil Infiltration; Obesity; Ozone; Phenotype; Respiratory Mechanics | 2008 |
[Immunoregulatory effects of pertussis protein on allergic asthma in mouse].
Topics: Albumins; Animals; Asthma; Bacterial Proteins; Bacterial Toxins; Bronchoalveolar Lavage Fluid; Interferon-gamma; Interleukin-4; Male; Methacholine Chloride; Mice; Mice, Inbred ICR | 2008 |
Asthma symptoms and bronchial reactivity in school children sensitized to food allergens in infancy.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Case-Control Studies; Child; Egg Hypersensitivity; Female; Food Hypersensitivity; Humans; Male; Methacholine Chloride; Risk Factors; Seafood; Skin Tests; Spirometry | 2008 |
Usefulness of induced sputum in investigating occupational asthma with normal responsiveness to methacholine: a case report.
Topics: Adult; Asthma; Cyanoacrylates; Eosinophils; Humans; Industry; Inhalation Exposure; Male; Methacholine Chloride; Occupational Exposure; Skin Tests; Sputum | 2008 |
Endothelin A receptor antagonist modulates lymphocyte and eosinophil infiltration, hyperreactivity and mucus in murine asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Endothelin A Receptor Antagonists; Eosinophils; Lung; Lymphocyte Subsets; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mucus; Ovalbumin; Peptides, Cyclic | 2008 |
Enhanced airway dilation by positive-pressure inflation of the lungs compared with active deep inspiration in patients with asthma.
Topics: Adult; Airway Resistance; Artificial Organs; Asthma; Bronchi; Bronchodilator Agents; Chest Wall Oscillation; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Positive-Pressure Respiration; Respiration, Artificial; Respiratory Mechanics; Young Adult | 2008 |
Reduced vital capacity after methacholine challenge in early childhood--is it due to trapped air or loss of motivation.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Child, Preschool; Forced Expiratory Volume; Functional Residual Capacity; Humans; Lung; Lung Volume Measurements; Methacholine Chloride; Motivation; Plethysmography, Whole Body; Spirometry; Vital Capacity | 2009 |
Body mass index, respiratory function and bronchial hyperreactivity in allergic rhinitis and asthma.
Topics: Administration, Inhalation; Adult; Asthma; Body Mass Index; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Military Personnel; Rhinitis, Allergic, Perennial; Risk Assessment; Sex Factors; Skin Tests; Spirometry | 2009 |
The extracellular matrix protein mindin regulates trafficking of murine eosinophils into the airspace.
Topics: Animals; Asthma; Cell Adhesion; Cell Movement; Eosinophils; Extracellular Matrix Proteins; Hypersensitivity; Immunoglobulin E; In Vitro Techniques; Integrin alpha4beta1; Interleukin-13; Interleukin-4; Lung; Macrophage-1 Antigen; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ovalbumin | 2009 |
Methacholine challenge methods.
Topics: Administration, Inhalation; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Forced Expiratory Volume; Humans; Methacholine Chloride; Nebulizers and Vaporizers | 2008 |
Improvement in pulmonary function after anticholinergic agents in spontaneous and methacholine induced asthma.
Topics: Acetylcholine; Asthma; Cholinergic Antagonists; Lung; Methacholine Chloride | 1948 |
Clinical implications of the effect of various anticholinergic agents in modifying the pulmonary response of asthmatic subjects to injected methacholine.
Topics: Acetylcholine; Asthma; Cholinergic Antagonists; Humans; Methacholine Chloride | 1948 |
Correlation between airway inflammation and loss of deep-inhalation bronchoprotection in asthma.
Topics: Adult; Asthma; Breath Tests; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Eosinophils; Female; Humans; Inflammation; Male; Methacholine Chloride; Nitric Oxide; Sputum | 2008 |
Development of a 1-concentration-4-step dosimeter protocol for methacholine testing.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Randomized Controlled Trials as Topic; Young Adult | 2009 |
The difference in ventilation heterogeneity between asthmatic and healthy subjects quantified using hyperpolarized 3He MRI.
Topics: Adult; Anti-Asthmatic Agents; Asthma; Bronchoconstrictor Agents; Female; Helium; Humans; Magnetic Resonance Imaging; Male; Methacholine Chloride; Middle Aged; Pilot Projects; Pulmonary Ventilation; Respiratory Function Tests; Young Adult | 2009 |
Bronchial hyperresponsiveness in a population of north Finland with no previous diagnosis of asthma or chronic bronchitis assessed with histamine and methacholine tests.
Topics: Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Female; Finland; Histamine; Humans; Male; Methacholine Chloride; Middle Aged; Prevalence; Young Adult | 2008 |
Gender differences in the prevalence of airway hyperresponsiveness and asthma in athletes.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Chi-Square Distribution; Exercise; Family Practice; Female; Forced Expiratory Volume; Humans; Hypersensitivity; Male; Methacholine Chloride; Prevalence; Retrospective Studies; Sex Factors; Sports; Surveys and Questionnaires | 2009 |
Immunoglobulin E antibodies enhance pulmonary inflammation induced by inhalation of a chemical hapten.
Topics: Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Count; Chemokine CCL2; Dinitrobenzenes; Disease Models, Animal; Eosinophils; Haptens; Immunization; Immunoglobulin E; Inflammation; Killer Cells, Natural; Lung; Metaplasia; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Natural Killer T-Cells; Occupational Diseases; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2009 |
Lung function changes following methacholine inhalation in COPD.
Topics: Adult; Aged; Asthma; Bronchoconstrictor Agents; England; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Oscillometry; Pulmonary Disease, Chronic Obstructive; Residual Volume; Spirometry; Vital Capacity | 2009 |
Comparisons of effects of intravenous and inhaled methacholine on airway physiology in a murine asthma model.
Topics: Administration, Inhalation; Airway Resistance; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Female; Injections, Intravenous; Lung Compliance; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ovalbumin; Pneumonia; Respiration, Artificial | 2009 |
Multiple challenges in a mouse model of chemical-induced asthma lead to tolerance: ventilatory and inflammatory responses are blunted, immunologic humoral responses are not.
Topics: Administration, Intranasal; Animals; Antibody Formation; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Immune Tolerance; Immunoglobulin E; Immunoglobulin G; Inflammation; Lung; Lymph Nodes; Lymphocytes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Respiratory Mechanics | 2009 |
Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model.
Topics: Alprenolol; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Epithelial Cells; Humans; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phenotype; Receptors, Adrenergic, beta-2; Signal Transduction | 2009 |
Effects of the phosphodiesterase type 4 inhibitor roflumilast on early and late allergic response and airway hyperresponsiveness in Aspergillus-fumigatus-sensitized mice.
Topics: Aminopyridines; Animals; Antigens, Fungal; Aspergillus fumigatus; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cyclopropanes; Disease Models, Animal; Eosinophils; Female; Leukocyte Count; Lymphocytes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Phosphodiesterase 4 Inhibitors; Pneumonia; Respiratory Hypersensitivity; Respiratory Mechanics | 2009 |
Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica.
Topics: Adolescent; Anti-Inflammatory Agents; Asthma; Biomarkers; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Costa Rica; Eosinophils; Female; Forced Expiratory Volume; Hospitalization; Humans; Hypersensitivity; Immunoglobulin E; Leukocyte Count; Male; Methacholine Chloride; Multivariate Analysis; Severity of Illness Index; Spirometry; Vitamin D | 2009 |
How to interpret reduced forced expiratory volume in 1 s (FEV1)/vital capacity ratio with normal FEV1.
Topics: Adult; Analysis of Variance; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Chi-Square Distribution; Female; Forced Expiratory Volume; Humans; Linear Models; Lung Volume Measurements; Male; Methacholine Chloride; Pulmonary Disease, Chronic Obstructive; Rhinitis; Spirometry; Surveys and Questionnaires; Vital Capacity | 2009 |
A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cell Count; Disease Models, Animal; Drug Delivery Systems; Heart Rate; Helium; Imaging, Three-Dimensional; Infusion Pumps; Lung; Magnetic Resonance Imaging; Methacholine Chloride; Mice; Ovalbumin; Pulmonary Ventilation; Reproducibility of Results; Time Factors | 2009 |
Exhaled leukotrienes and bronchial responsiveness to methacholine in patients with seasonal allergic rhinitis.
Topics: Adult; Anti-Asthmatic Agents; Asthma; Bronchi; Exhalation; Female; Humans; Leukotriene B4; Leukotriene E4; Male; Methacholine Chloride; Middle Aged; Reference Standards; Rhinitis, Allergic, Seasonal; Young Adult | 2009 |
Altered regulation of aquaporin gene expression in allergen and IL-13-induced mouse models of asthma.
Topics: Animals; Aquaporin 1; Aquaporin 4; Aquaporin 5; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Female; Gene Expression Regulation; Inflammation; Interleukin-13; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Models, Biological | 2009 |
Diagnosing asthma in general practice with portable exhaled nitric oxide measurement--results of a prospective diagnostic study: FENO < or = 16 ppb better than FENO < or =12 ppb to rule out mild and moderate to severe asthma [added].
Topics: Adult; Aged; Asthma; Breath Tests; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Electrochemical Techniques; Equipment Design; Exhalation; Family Practice; Female; Forced Expiratory Volume; Germany; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Netherlands; Nitric Oxide; Predictive Value of Tests; Prospective Studies; Sensitivity and Specificity; Severity of Illness Index; Vital Capacity; Young Adult | 2009 |
Airway hyper-responsiveness in young adults with asthma that remitted either during or before adolescence.
Topics: Adolescent; Adult; Aging; Asthma; Bronchial Provocation Tests; Case-Control Studies; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Nitric Oxide; Recurrence; Remission, Spontaneous; Respiratory Function Tests; Respiratory Hypersensitivity; Risk Factors | 2009 |
Subcutaneous prostaglandin E(2) restrains airway mast cell activity in vivo and reduces lung eosinophilia and Th(2) cytokine overproduction in house dust mite-sensitive mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Chemokine CCL2; Cytokines; Dinoprostone; Disease Models, Animal; Eosinophils; Female; Infusions, Subcutaneous; Lung; Mast Cells; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pulmonary Eosinophilia; Pyroglyphidae; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Th2 Cells | 2009 |
Is toluene diamine a sensitizer and is there cross-reactivity between toluene diamine and toluene diisocyanate?
Topics: Animals; Antigens, CD; Asthma; Cells, Cultured; Cross Reactions; Cytokines; Disease Models, Animal; Immunoglobulins; Local Lymph Node Assay; Lymphocytes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Phenylenediamines; Statistics, Nonparametric; Toluene 2,4-Diisocyanate | 2009 |
The contribution of Ca2+ signaling and Ca2+ sensitivity to the regulation of airway smooth muscle contraction is different in rats and mice.
Topics: Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Calcium; Calcium Signaling; Disease Models, Animal; Male; Membrane Potentials; Methacholine Chloride; Mice; Mice, Inbred BALB C; Muscle, Smooth; Potassium Chloride; Protein Kinase C; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Serotonin; Species Specificity; Temperature; Trachea | 2009 |
Fms-like tyrosine kinase 3 ligand increases a lung DC subset with regulatory properties in allergic airway inflammation.
Topics: Animals; Asthma; Bronchial Hyperreactivity; CD11b Antigen; CD11c Antigen; Cytokines; Dendritic Cells; Female; Immunophenotyping; Lung; Lymphocyte Activation; Membrane Proteins; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; T-Lymphocytes; Th2 Cells | 2009 |
Predictive value of sGaw, FEF(25-75), and FEV1 for development of asthma after a negative methacholine challenge test.
Topics: Asthma; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Middle Aged; Predictive Value of Tests; Respiratory Function Tests; Retrospective Studies | 2009 |
Oropharyngeal aspiration: an alternative route for challenging in a mouse model of chemical-induced asthma.
Topics: Administration, Intranasal; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; Eosinophils; Immunoglobulin E; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Respiratory Aspiration; Toluene 2,4-Diisocyanate; Up-Regulation | 2009 |
The prone position results in smaller ventilation defects during bronchoconstriction in asthma.
Topics: Adult; Asthma; Bronchoconstriction; Female; Humans; Lung; Male; Methacholine Chloride; Nitrogen Radioisotopes; Prone Position; Pulmonary Gas Exchange; Pulmonary Ventilation; Respiratory Mechanics; Spirometry; Young Adult | 2009 |
Deep inspirations protect against airway closure in nonasthmatic subjects.
Topics: Administration, Inhalation; Adult; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Functional Residual Capacity; Humans; Inhalation; Male; Methacholine Chloride; Middle Aged; Vital Capacity; Young Adult | 2009 |
Relationship between amphiregulin and airway inflammation in children with asthma and eosinophilic bronchitis.
Topics: Amphiregulin; Analysis of Variance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Case-Control Studies; Child; EGF Family of Proteins; Enzyme-Linked Immunosorbent Assay; Eosinophils; Female; Glycoproteins; Humans; Immunoglobulin E; Inflammation; Intercellular Signaling Peptides and Proteins; Leukocyte Count; Male; Methacholine Chloride; Mucins; Prospective Studies; Sputum; Statistics, Nonparametric; Up-Regulation | 2009 |
[Measurement of airway resistance and reactivity in guinea pigs using double-chamber plethysmography].
Topics: Airway Resistance; Animals; Asthma; Bronchial Hyperreactivity; Guinea Pigs; Male; Methacholine Chloride; Plethysmography; Random Allocation | 2009 |
Effects of methacholine challenge on alveolar nitric oxide.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Humans; Methacholine Chloride; Nitric Oxide; Pulmonary Alveoli | 2009 |
Airway hyperresponsiveness is associated with activated CD4+ T cells in the airways.
Topics: Airway Resistance; Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Disease Models, Animal; Female; Immunoglobulin E; Immunoglobulin G; Lectins, C-Type; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ovalbumin; Specific Pathogen-Free Organisms | 2009 |
An evaluation of the use of bronchoconstriction induced by deep inspiration as a new epidemiological measure for asthma.
Topics: Adolescent; Adult; Aged; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Cross-Sectional Studies; Female; Humans; Incidence; Inhalation; Linear Models; Logistic Models; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Probability; Registries; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Young Adult | 2009 |
A MCh test pre-post esophageal acidification in detecting GER-related asthma.
Topics: Adult; Age Distribution; Area Under Curve; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Case-Control Studies; Comorbidity; Confidence Intervals; Esophageal pH Monitoring; Female; Forced Expiratory Volume; Gastroesophageal Reflux; Humans; Italy; Male; Manometry; Methacholine Chloride; Middle Aged; Prevalence; Prognosis; Reference Values; Respiratory Function Tests; Risk Assessment; ROC Curve; Severity of Illness Index; Sex Distribution | 2009 |
The FEF25-75 and its decline as a predictor of methacholine responsiveness in children.
Topics: Adolescent; Area Under Curve; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Chi-Square Distribution; Child; Child, Preschool; Cohort Studies; Disease Progression; Female; Forced Expiratory Flow Rates; Hospitals, Pediatric; Humans; Male; Methacholine Chloride; Prognosis; Retrospective Studies; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Spirometry; Statistics, Nonparametric; Vital Capacity | 2009 |
Modifications in forced vital capacity during adenosine monophosphate-induced bronchoconstriction in asthma: relationship with the response to methacholine and the effect of inhaled corticosteroids.
Topics: Adenosine Monophosphate; Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Vital Capacity; Young Adult | 2009 |
Effect of allergen challenge on the percentage of natural killer T cells in patients with atopic asthma.
Topics: Adult; Allergens; Asthma; Blood Cells; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Eosinophils; Female; Forced Expiratory Volume; Humans; Lymphocyte Count; Male; Methacholine Chloride; Natural Killer T-Cells; Neutrophils; Young Adult | 2009 |
The potential use of spirometry during methacholine challenge test in young children with respiratory symptoms.
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Child, Preschool; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; ROC Curve; Spirometry | 2009 |
Hospital admission for acute painful episode following methacholine challenge in an adolescent with sickle cell disease.
Topics: Adolescent; Anemia, Sickle Cell; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Chest Pain; Humans; Male; Methacholine Chloride | 2009 |
Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Humans; Immunoglobulin E; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ovalbumin | 2009 |
Aerosolized methacholine-induced bronchoconstriction and pulmonary hyperinflation in rats.
Topics: Administration, Inhalation; Aerosols; Animals; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Functional Residual Capacity; Lung; Lung Volume Measurements; Male; Methacholine Chloride; Plethysmography, Whole Body; Rats; Rats, Wistar | 2009 |
IL-18 in induced sputum and airway hyperresponsiveness in mild asthmatics: effect of smoking.
Topics: Adult; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cell Count; Humans; Interleukin-18; Methacholine Chloride; Middle Aged; Respiratory Function Tests; Smoking; Sputum | 2009 |
Vaccine-induced CD8+ T cell-dependent suppression of airway hyperresponsiveness and inflammation.
Topics: Adoptive Transfer; Animals; Asthma; Bronchial Hyperreactivity; Cations; CD8-Positive T-Lymphocytes; Cytokines; Epitopes, T-Lymphocyte; Female; H-2 Antigens; Humans; Immunosuppressive Agents; Inflammation Mediators; Liposomes; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovalbumin; Vaccines, DNA | 2009 |
Airway hyperresponsiveness: a comparative study of methacholine and exercise challenges in seasonal allergic rhinitis with or without asthma.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Exercise Test; Female; Humans; Male; Methacholine Chloride; Respiratory Function Tests; Rhinitis, Allergic, Seasonal; Skin Tests | 2009 |
Effect of bronchoconstriction on exhaled nitric oxide levels in healthy and asthmatic children.
Topics: Adolescent; Airway Resistance; Asthma; Biomarkers; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Child; Child, Preschool; Disease Progression; Exhalation; Female; Humans; Male; Methacholine Chloride; Nitric Oxide | 2009 |
Utility and limitations of objective measures of asthma.
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Exhalation; Humans; Methacholine Chloride; Nitric Oxide; Saline Solution, Hypertonic; Spirometry | 2009 |
Limitations of objective measures of asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Humans; Methacholine Chloride; Middle Aged; Nitric Oxide; Saline Solution, Hypertonic; Spirometry | 2009 |
Modulation of lung inflammation by vessel dilator in a mouse model of allergic asthma.
Topics: Administration, Intranasal; Animals; Asthma; Atrial Natriuretic Factor; Bronchoconstrictor Agents; Cell Line; Chitosan; Cytokines; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Humans; Luciferases; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nanoparticles; Ovalbumin; Peptide Fragments; Pneumonia; Receptors, Atrial Natriuretic Factor; Respiratory Hypersensitivity; Reverse Transcriptase Polymerase Chain Reaction; Th2 Cells; Transfection | 2009 |
Peroxiredoxin I is a negative regulator of Th2-dominant allergic asthma.
Topics: Airway Resistance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Lung; Methacholine Chloride; Mice; Mice, Knockout; Nitric Oxide; Peroxiredoxins; T-Lymphocytes; Th2 Cells | 2009 |
The effects of repeated allergen challenge on airway smooth muscle structural and molecular remodeling in a rat model of allergic asthma.
Topics: Allergens; Animals; Asthma; Blotting, Western; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Disease Models, Animal; Male; Methacholine Chloride; Muscle, Smooth; Ovalbumin; Rats; Rats, Inbred BN; Receptor, Muscarinic M3; Respiratory System; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2009 |
Specific conductance criteria for a positive methacholine challenge test: are the American Thoracic Society guidelines rather generous?
Topics: Adult; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Practice Guidelines as Topic; Predictive Value of Tests; ROC Curve | 2009 |
Bronchodilator response after negative methacholine challenge test predicts future diagnosis of asthma.
Topics: Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Predictive Value of Tests; ROC Curve; Sensitivity and Specificity; Young Adult | 2009 |
Two ATS recommended protocols for administration of methacholine are not equal.
Topics: Administration, Inhalation; Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Confounding Factors, Epidemiologic; False Negative Reactions; Female; Forced Expiratory Volume; Humans; Logistic Models; Male; Methacholine Chloride; Middle Aged; Odds Ratio; Vital Capacity | 2009 |
Resistance and reactance in oscillation lung function reflect basal lung function and bronchial hyperresponsiveness respectively.
Topics: Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Case-Control Studies; Child; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Oscillometry; Spirometry | 2009 |
Relationship between bronchial hyperreactivity and asthma remission during adolescence.
Topics: Adolescent; Adolescent Development; Age Factors; Asthma; Bronchoconstriction; Child; Child, Preschool; Female; Humans; Male; Methacholine Chloride; Puberty; Remission, Spontaneous; Vital Capacity; Young Adult | 2009 |
[Diagnostic value of peak flow variability in patients with suspected diagnosis of bronchial asthma in general practice].
Topics: Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Diagnosis, Differential; Family Practice; Humans; Methacholine Chloride; Peak Expiratory Flow Rate; Plethysmography, Whole Body; Predictive Value of Tests; Pulmonary Disease, Chronic Obstructive; Reference Standards; ROC Curve; Sensitivity and Specificity; Spirometry | 2009 |
Nitric oxide measurement in chronic cough.
Topics: Adrenal Cortex Hormones; Asthma; Biomarkers; Breath Tests; Bronchitis; Bronchoconstrictor Agents; Chronic Disease; Cough; Humans; Methacholine Chloride; Nitric Oxide; Pulmonary Eosinophilia | 2010 |
Galectin-9 in allergic airway inflammation and hyper-responsiveness in mice.
Topics: Allergens; Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cell Movement; Cytokines; Dexamethasone; Disease Models, Animal; Female; Galectins; Granulocytes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Ovalbumin; Respiratory Function Tests | 2010 |
Seasonal variability of the methacholine challenge test.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Retrospective Studies; Seasons; Young Adult | 2009 |
Effects of obesity on perceptual and mechanical responses to bronchoconstriction in asthma.
Topics: Adult; Asthma; Body Mass Index; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cross-Sectional Studies; Dose-Response Relationship, Drug; Dyspnea; Female; Forced Expiratory Volume; Humans; Illness Behavior; Inspiratory Capacity; Lung Volume Measurements; Male; Methacholine Chloride; Middle Aged; Obesity; Plethysmography; Respiratory Mechanics; Sex Factors; Spirometry; Young Adult | 2010 |
Nerve growth factor mediated SH2-Bbeta/Akt signal pathway activated in allergic airway challenge in mice.
Topics: Adaptor Proteins, Signal Transducing; Airway Resistance; Animals; Asthma; Bronchial Hyperreactivity; Constriction, Pathologic; Female; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nerve Growth Factor; Ovalbumin; Proto-Oncogene Proteins c-akt | 2010 |
β-2 agonists in sport: are the anti-doping rules meeting the needs of asthmatic athletes?
Topics: Adrenergic beta-2 Receptor Agonists; Airway Obstruction; Anti-Asthmatic Agents; Asthma; Body Height; Body Weight; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bronchodilator Agents; Doping in Sports; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Needs Assessment; Young Adult | 2011 |
Clinical and inflammatory features of occupational asthma caused by persulphate salts in comparison with asthma associated with occupational rhinitis.
Topics: Adult; Ammonium Sulfate; Asthma; Eosinophilia; Female; Humans; Inflammation; Male; Methacholine Chloride; Occupational Diseases; Retrospective Studies; Rhinitis; Young Adult | 2010 |
Exhaled nitric oxide and airway hyperresponsiveness in workers: a preliminary study in lifeguards.
Topics: Adult; Asthma; Bronchial Provocation Tests; Cross-Sectional Studies; Feasibility Studies; Female; Forced Expiratory Volume; Humans; Linear Models; Male; Methacholine Chloride; Nitric Oxide; Occupational Health; Predictive Value of Tests; Respiratory Hypersensitivity; Sensitivity and Specificity; Spirometry; Swimming | 2009 |
Bronchoconstriction-triggered cough is impaired in typical asthmatics.
Topics: Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Cough; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Vital Capacity; Young Adult | 2010 |
Impact of allergic rhinitis on asthma in children: effects on bronchial hyperreactivity.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Risk Factors; Time Factors | 2010 |
Quantitative analysis of hyperpolarized 3He ventilation changes in mice challenged with methacholine.
Topics: Administration, Inhalation; Algorithms; Animals; Asthma; Contrast Media; Helium; Image Enhancement; Isotopes; Magnetic Resonance Imaging; Methacholine Chloride; Mice; Mice, Inbred C57BL; Reproducibility of Results; Sensitivity and Specificity | 2010 |
Mannitol and AMP do not induce bronchoconstriction in eosinophilic bronchitis: further evidence for dissociation between airway inflammation and bronchial hyperresponsiveness.
Topics: Adenosine Monophosphate; Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Bronchoconstriction; Case-Control Studies; Eosinophilia; Eosinophils; Female; Histamine; Humans; Male; Mannitol; Methacholine Chloride; Middle Aged; Pneumonia; Sputum | 2010 |
Changes in the highest frequency of breath sounds without wheezing during methacholine inhalation challenge in children.
Topics: Administration, Inhalation; Adolescent; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoconstriction; Bronchodilator Agents; Child; Female; Humans; Male; Methacholine Chloride; Respiratory Mechanics; Respiratory Sounds; Retrospective Studies; Spirometry | 2010 |
Perimenstrual increase in bronchial hyperreactivity in premenopausal women: results from the population-based SAPALDIA 2 cohort.
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Cohort Studies; Contraceptives, Oral; Female; Humans; Menstruation; Methacholine Chloride; Middle Aged; Premenopause; Prevalence; Surveys and Questionnaires; Young Adult | 2010 |
Airway hyperresponsiveness, peak flow variability and inflammatory markers in non-asthmatic subjects with respiratory infections.
Topics: Adenosine; Adult; Aged; Air; Asthma; Biomarkers; Breath Tests; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cold Temperature; Common Cold; Eosinophil Cationic Protein; Humans; Inflammation; Methacholine Chloride; Middle Aged; Nitric Oxide; Peak Expiratory Flow Rate; Respiratory Sounds; Young Adult | 2007 |
Increased exhaled nitrite in children with allergic asthma is not related to nitric oxide formation.
Topics: Adolescent; Asthma; Breath Tests; Bronchial Provocation Tests; Case-Control Studies; Child; Cohort Studies; Eosinophils; Exhalation; Female; Humans; Inflammation Mediators; Male; Methacholine Chloride; Nitric Oxide; Nitrites; Probability; Reference Values; Sensitivity and Specificity; Severity of Illness Index; Spirometry; Statistics, Nonparametric | 2008 |
Airway hyperresponsiveness and airway inflammation in elite swimmers.
Topics: Adolescent; Adult; Asthma; Athletes; Breath Tests; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cohort Studies; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Incidence; Male; Methacholine Chloride; Nitric Oxide; Respiratory Function Tests; Sputum; Swimming; Young Adult | 2009 |
Ammonium persulfate can initiate an asthmatic response in mice.
Topics: Ammonium Sulfate; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cell Proliferation; Cells, Cultured; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Immunoglobulin E; Lymph Nodes; Lymphocyte Activation; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C | 2010 |
Mild asthma in overweight women: A new phenotype?
Topics: Adenosine Monophosphate; Adult; Aged; Asthma; Body Mass Index; Bronchoconstrictor Agents; Female; Humans; Methacholine Chloride; Middle Aged; Overweight; Phenotype; Respiratory Function Tests; Surveys and Questionnaires | 2010 |
[Asthma therapy in the doctor's office].
Topics: Adult; Anti-Asthmatic Agents; Asthma; Breath Tests; Bronchial Provocation Tests; Child; Child, Preschool; Humans; Methacholine Chloride; Nitric Oxide; Referral and Consultation | 2010 |
IgE production in allergic asthmatic patients with different asthma control status.
Topics: Adult; Aged; Asthma; Bronchial Provocation Tests; Eosinophils; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Middle Aged; Skin Tests; Spirometry | 2010 |
Reversal of methylprednisolone effects in allergen-exposed female BALB/c mice.
Topics: Administration, Intranasal; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cyclosporine; Disease Models, Animal; Drug Antagonism; Female; Glucocorticoids; Immunosuppressive Agents; Injections, Intraperitoneal; Lung; Methacholine Chloride; Methylprednisolone; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Function Tests; Respiratory Hypersensitivity | 2010 |
Ozone increases airway hyperreactivity and mucus hyperproduction in mice previously exposed to allergen.
Topics: Air Pollutants; Allergens; Animals; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Interactions; Inhalation Exposure; Leukocyte Count; Leukocytes; Lung; Methacholine Chloride; Mice; Mucus; Ovalbumin; Ozone; Periodic Acid-Schiff Reaction; Respiratory Function Tests | 2010 |
Airway inflammation and remodeling in two mouse models of asthma: comparison of males and females.
Topics: Airway Remodeling; Animals; Asthma; Cytokines; Disease Models, Animal; Eosinophils; Female; Immunoglobulin E; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Pyroglyphidae; Sex Characteristics | 2010 |
[The detection of biphasic reactivity of the airway by astograph].
Topics: Adult; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Humans; Methacholine Chloride | 2010 |
Increased expression of angiopoietins and Tie2 in the lungs of chronic asthmatic mice.
Topics: Angiopoietin-1; Angiopoietin-2; Animals; Asthma; Gene Expression Regulation; Hypersensitivity; Inflammation; Macrophages; Methacholine Chloride; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Models, Biological; Ovalbumin; Receptor Protein-Tyrosine Kinases; Receptor, TIE-2; Vascular Endothelial Growth Factor A | 2011 |
Histamine and methacholine challenge cut points.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Provocation Tests; Female; Histamine; Humans; Male; Methacholine Chloride; Sensitivity and Specificity | 2010 |
Increase in exhaled nitric oxide is associated with bronchial hyperresponsiveness among apprentices.
Topics: Adolescent; Asthma; Beauty Culture; Biomarkers; Breath Tests; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Exhalation; Female; Follow-Up Studies; Food-Processing Industry; Humans; Incidence; Inflammation; Inhalation Exposure; Male; Methacholine Chloride; Nitric Oxide; Occupational Diseases; Occupational Exposure; Surveys and Questionnaires | 2010 |
Thalidomide attenuates airway hyperresponsiveness and eosinophilic inflammation in a murine model of allergic asthma.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Female; Goblet Cells; Hyperplasia; Inflammation; Interleukin-5; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Thalidomide; Tumor Necrosis Factor-alpha | 2010 |
Eosinophils are required for the induction of bronchial hyperresponsiveness in a Th transfer model of BALB/c background.
Topics: Airway Resistance; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Count; Eosinophils; GATA1 Transcription Factor; Lymphocytes; Macrophages; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Monocytes; Neutrophils; Ovalbumin; T-Lymphocytes, Helper-Inducer | 2010 |
Ethnic differences in methacholine responsiveness and word descriptors in African Americans, Hispanic-Mexican Americans, Asian-Pacific Islanders, and Whites with mild asthma.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Cross-Cultural Comparison; Female; Humans; Language; Male; Methacholine Chloride; Middle Aged; Racial Groups; Respiratory Function Tests; Young Adult | 2010 |
Concomitant administration of nitric oxide and glucocorticoids improves protection against bronchoconstriction in a murine model of asthma.
Topics: Administration, Inhalation; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cyclic GMP; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Female; Glucocorticoids; Guanylate Cyclase; Hydrazines; Hydrocortisone; Injections, Intraperitoneal; Lipopolysaccharides; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Ovalbumin; Oxadiazoles; Pneumonia; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Receptors, Glucocorticoid; Respiration, Artificial; Respiratory Mechanics; Soluble Guanylyl Cyclase | 2010 |
Selective nasal allergen provocation induces substance P-mediated bronchial hyperresponsiveness.
Topics: Administration, Inhalation; Allergens; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Immunization; Leukocyte Count; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nasal Provocation Tests; Neurokinin-1 Receptor Antagonists; Ovalbumin; Receptors, Neurokinin-1; Substance P; Tryptophan; Up-Regulation | 2011 |
IL-12-STAT4-IFN-gamma axis is a key downstream pathway in the development of IL-13-mediated asthma phenotypes in a Th2 type asthma model.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Interferon-gamma; Interleukin-12; Interleukin-12 Receptor beta 2 Subunit; Interleukin-13; Interleukin-4; Methacholine Chloride; Mice; Mice, Transgenic; Models, Immunological; Organ Specificity; Pneumonia; Receptors, Cell Surface; Signal Transduction; STAT4 Transcription Factor; Th2 Cells | 2010 |
Sex-specific lung remodeling and inflammation changes in experimental allergic asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Chronic Disease; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Matrix; Female; Inflammation Mediators; Interleukin-4; Interleukin-5; Lung; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Ovariectomy; Pneumonia; Sex Factors; Time Factors; Transforming Growth Factor beta | 2010 |
Late asthmatic reaction induced by exposure to raw Swiss chard.
Topics: Asthma; Female; Humans; Hypersensitivity, Delayed; Immunoglobulin E; Methacholine Chloride; Middle Aged; Respiratory Function Tests; Skin Tests; Vegetables | 2010 |
Inhaled magnesium fluoride reverse bronchospasma.
Topics: Administration, Inhalation; Airway Resistance; Animals; Asthma; Bronchoconstriction; Bronchodilator Agents; Fluorides; Magnesium Compounds; Magnesium Sulfate; Male; Methacholine Chloride; Rats; Rats, Wistar; Sodium Fluoride | 2010 |
Association between obesity and the prevalence of allergic diseases, atopy, and bronchial hyperresponsiveness in Korean adolescents.
Topics: Adolescent; Asthma; Body Mass Index; Bronchial Hyperreactivity; Cross-Sectional Studies; Dermatitis, Atopic; Eosinophils; Female; Humans; Hypersensitivity; Immunoglobulin E; Leukocyte Count; Male; Methacholine Chloride; Obesity; Prevalence; Republic of Korea; Respiratory Function Tests; Respiratory Sounds; Sex Factors; Skin Tests | 2011 |
Avoiding deep inspirations increases the maximal response to methacholine without altering sensitivity in non-asthmatics.
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Respiratory Function Tests; Respiratory Mechanics; Vital Capacity | 2010 |
Respiratory symptoms and bronchial responsiveness in competitive swimmers.
Topics: Adolescent; Adult; Asthma; Athletes; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Sectional Studies; Female; Humans; Male; Methacholine Chloride; Prevalence; Respiratory Function Tests; Swimming; Young Adult | 2011 |
Occupational asthma caused by triglycidyl isocyanurate.
Topics: Adult; Antineoplastic Agents; Asthma; Breath Tests; Female; Humans; Inhalation Exposure; Methacholine Chloride; Occupational Diseases; Paint; Triazines | 2011 |
Airway hyperresponsiveness in children with sickle cell anemia.
Topics: Administration, Inhalation; Adolescent; Age Factors; Anemia, Sickle Cell; Asthma; Bronchial Provocation Tests; Child; Child, Preschool; Cohort Studies; Female; Humans; Immunoglobulin E; L-Lactate Dehydrogenase; Linear Models; Lung; Male; Methacholine Chloride; Prevalence; Prospective Studies; Respiratory Function Tests; Risk Factors; Young Adult | 2011 |
Annexin 1-derived peptide Ac2-26 inhibits eosinophil recruitment in vivo via decreasing prostaglandin D₂.
Topics: Animals; Annexin A1; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Dinoprostone; Dose-Response Relationship, Immunologic; Eosinophils; Female; Immunoglobulin E; Immunohistochemistry; Male; Methacholine Chloride; Peptides; Plethysmography; Rats; Rats, Wistar; Specific Pathogen-Free Organisms; Statistics, Nonparametric | 2011 |
Bronchial reactivity indices are determinants of health-related quality of life in patients with stable asthma.
Topics: Adolescent; Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Health Status; Humans; Male; Methacholine Chloride; Middle Aged; Psychometrics; Quality of Life; Respiratory Function Tests; Vital Capacity; Young Adult | 2010 |
Airway responsiveness to inhaled aspirin is influenced by airway hyperresponsiveness in asthmatic patients.
Topics: Administration, Inhalation; Adolescent; Adult; Aspirin; Asthma; Asthma, Aspirin-Induced; Bronchial Hyperreactivity; Bronchial Provocation Tests; Drug Hypersensitivity; Female; Humans; Male; Methacholine Chloride; Retrospective Studies; Young Adult | 2010 |
Bronchial hyperreactivity to methacholine in atopic versus nonatopic asthmatic schoolchildren and preschoolers.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Chi-Square Distribution; Child; Child, Preschool; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride; Retrospective Studies; Skin Tests | 2010 |
Proinflammatory doses of diesel exhaust in healthy subjects fail to elicit equivalent or augmented airway inflammation in subjects with asthma.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchoscopy; Epidemiologic Methods; Female; Forced Expiratory Volume; Humans; Inflammation Mediators; Inhalation Exposure; Male; Methacholine Chloride; Neutrophil Infiltration; Nitric Oxide; Peak Expiratory Flow Rate; Vehicle Emissions; Young Adult | 2011 |
A nocturnal decline of salivary pH associated with airway hyperresponsiveness in asthma.
Topics: Adult; Asthma; Buffers; Case-Control Studies; Circadian Rhythm; Female; Gastroesophageal Reflux; Humans; Hydrogen-Ion Concentration; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests; Respiratory Hypersensitivity; Saliva; Vagus Nerve | 2010 |
Proteome analysis of multiple compartments in a mouse model of chemical-induced asthma.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Inflammation; Mass Spectrometry; Methacholine Chloride; Mice; Neutrophils; Oxidative Stress; Proteome; Toluene 2,4-Diisocyanate | 2010 |
Problematic severe asthma: a proposed approach to identifying children who are severely resistant to therapy.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Cross-Sectional Studies; Exhalation; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Nitric Oxide; Respiratory Function Tests; Rhinitis; Severity of Illness Index; Spirometry; Surveys and Questionnaires | 2011 |
Successful transfer of chemical-induced asthma by adoptive transfer of low amounts of lymphocytes in a mouse model.
Topics: Adoptive Transfer; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Immunoglobulin E; Lymphocytes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Time Factors; Toluene 2,4-Diisocyanate | 2011 |
Methacholine is more sensitive than mannitol for evaluation of bronchial hyperresponsiveness in children with asthma.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Female; Humans; Male; Mannitol; Methacholine Chloride; Respiratory Function Tests | 2010 |
Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide: a random-sample population study.
Topics: Adolescent; Area Under Curve; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Sectional Studies; Exhalation; Female; Humans; Male; Mannitol; Methacholine Chloride; Nitric Oxide; ROC Curve; Sensitivity and Specificity; Young Adult | 2010 |
Medical surveillance programme for diisocyanate exposure.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Humans; Isocyanates; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Occupational Exposure; Population Surveillance; Prognosis; Program Evaluation; Prospective Studies; Workers' Compensation | 2011 |
Airway hyperresponsiveness to methacholine in 7-year-old children: sensitivity and specificity for pediatric allergist-diagnosed asthma.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Cohort Studies; Female; Humans; Male; Methacholine Chloride; Sensitivity and Specificity | 2011 |
Tidal airway closure during bronchoconstriction in asthma: usefulness of lung volume measurements.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Female; Functional Residual Capacity; Humans; Lung Volume Measurements; Male; Methacholine Chloride; Oxyhemoglobins; Plethysmography, Whole Body; Pulmonary Ventilation; Residual Volume; Tidal Volume; Vital Capacity | 2011 |
Effects of oral monosodium glutamate in mouse models of asthma.
Topics: Administration, Oral; Animals; Asthma; Body Weight; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Eosinophils; Immunoglobulin E; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Sodium Glutamate; Trachea | 2011 |
Bronchodilation response to deep inspirations in asthma is dependent on airway distensibility and air trapping.
Topics: Adolescent; Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Female; Humans; Inhalation; Male; Methacholine Chloride; Middle Aged; Young Adult | 2011 |
Diagnostic value of exhaled nitric oxide in childhood asthma and allergy.
Topics: Asthma; Breath Tests; Child; Exhalation; Feasibility Studies; Female; Follow-Up Studies; Humans; Hypersensitivity; Immunization; Male; Methacholine Chloride; Nitric Oxide; Sensitivity and Specificity; Skin Tests | 2010 |
Negative methacholine challenge tests in subjects who report physician-diagnosed asthma.
Topics: Adolescent; Adult; Aged; Asthma; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Middle Aged; Physicians; Young Adult | 2011 |
Association of bronchial reactivity to occupational agents with methacholine reactivity, sputum cells and immunoglobulin E-mediated reactivity.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Eosinophils; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Neutrophils; Occupational Diseases; Predictive Value of Tests; Retrospective Studies; Sputum | 2011 |
Maximal degree of airway narrowing induced by methacholine and adenosine monophosphate: relationship with the decrease in forced vital capacity.
Topics: Adenosine Monophosphate; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Female; Humans; Male; Methacholine Chloride; Middle Aged; Pollen; Rhinitis, Allergic, Perennial; Vital Capacity | 2010 |
Comparison of central and peripheral airway involvement before and during methacholine, mannitol and eucapnic hyperventilation challenges in mild asthmatics.
Topics: Administration, Inhalation; Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Cross-Sectional Studies; Female; Humans; Male; Mannitol; Methacholine Chloride; Middle Aged; Nitric Oxide; Oscillometry; Spirometry; Statistics, Nonparametric | 2011 |
Confirmation of asthma diagnosis in the community.
Topics: Algorithms; Asthma; Bronchial Hyperreactivity; Diagnostic Errors; Humans; Methacholine Chloride; Pulmonary Medicine; Spirometry; Steroids | 2011 |
Confirmation of asthma diagnosis in the community.
Topics: Algorithms; Asthma; Bronchial Hyperreactivity; Diagnostic Errors; Humans; Methacholine Chloride; Pulmonary Medicine; Regression Analysis; Spirometry; Steroids | 2011 |
Bronchial hyperresponsiveness to methacholine and adenosine 5'-monophosphate, and the presence and degree of atopy in young children with asthma.
Topics: Adenosine Monophosphate; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Child, Preschool; Humans; Hypersensitivity, Immediate; Methacholine Chloride; Retrospective Studies; Skin Tests | 2011 |
Bronchodilator responsiveness following a negative methacholine challenge test.
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Diagnosis, Differential; Follow-Up Studies; Humans; Male; Methacholine Chloride; Middle Aged | 2011 |
Hesperidin suppresses ovalbumin-induced airway inflammation in a mouse allergic asthma model.
Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Hesperidin; Immunoglobulin E; Inflammation; Interleukin-13; Interleukin-4; Interleukin-5; Leukocytes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory System; Th2 Cells | 2012 |
Control maintenance can be predicted by exhaled NO monitoring in asthmatic patients.
Topics: Adult; Albuterol; Anti-Inflammatory Agents; Asthma; Biomarkers; Dyspnea; Exhalation; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Nitric Oxide; Predictive Value of Tests; Prospective Studies; Respiratory Function Tests | 2011 |
Methacholine and adenosine 5'-monophosphate (AMP) responsiveness, and the presence and degree of atopy in children with asthma.
Topics: Adenosine Monophosphate; Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Eosinophils; Female; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride; Skin Tests; Spirometry | 2011 |
Quality-of-life, psychological, and cost outcomes 2 years after diagnosis of occupational asthma.
Topics: Adult; Asthma; Bronchoconstrictor Agents; Cost of Illness; Cross-Sectional Studies; Female; Humans; Longitudinal Studies; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Psychiatric Status Rating Scales; Quality of Life; Quebec; Severity of Illness Index; Skin Tests; Socioeconomic Factors; Spirometry; Sputum; Surveys and Questionnaires; Workers' Compensation | 2011 |
Inhibition of airway inflammation, hyperresponsiveness and remodeling by soy isoflavone in a murine model of allergic asthma.
Topics: Airway Remodeling; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chemokine CCL11; Collagen; Eosinophils; Female; Glycine max; Hypersensitivity; Inflammation; Interferon-gamma; Interleukin-4; Interleukin-5; Isoflavones; Lung; Matrix Metalloproteinase 9; Methacholine Chloride; Mice; Mice, Inbred ICR; Mucus; Ovalbumin; Peroxidase; Respiratory System; Superoxide Dismutase; Tissue Inhibitor of Metalloproteinase-1 | 2011 |
PPARγ agonist rosiglitazone prevents perinatal nicotine exposure-induced asthma in rat offspring.
Topics: Animals; Animals, Newborn; Asthma; Female; Methacholine Chloride; Nicotine; PPAR gamma; Pregnancy; Rats; Rats, Sprague-Dawley; Respiratory Function Tests; Rosiglitazone; Thiazolidinediones; Trachea | 2011 |
Strain-dependent genomic factors affect allergen-induced airway hyperresponsiveness in mice.
Topics: Airway Resistance; Allergens; Animals; Antigens, Dermatophagoides; Arthropod Proteins; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cysteine Endopeptidases; Cytokines; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Genetic Predisposition to Disease; Immunoglobulin E; Immunoglobulin G; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mucins; Phenotype; Receptors, G-Protein-Coupled; Th2 Cells; Time Factors | 2011 |
Bronchoprovocation testing in asthma: effect on exhaled monoxides.
Topics: Adult; Allergens; Asthma; Breath Tests; Bronchial Provocation Tests; Bronchoconstrictor Agents; Carbon Monoxide; Cohort Studies; Exhalation; Female; Humans; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Spirometry | 2010 |
Adenosine 5'-monophosphate challenge elicits a more peripheral airway response than methacholine challenge.
Topics: Adenosine Monophosphate; Adult; Asthma; Female; Humans; Lung; Male; Methacholine Chloride; Pulmonary Ventilation; Respiratory Function Tests | 2011 |
Recruitment of asthmatic ethnic minorities into a methacholine research study: factors influencing participation.
Topics: Adult; Asthma; Bronchoconstrictor Agents; Ethnicity; Female; Humans; Male; Methacholine Chloride; Patient Participation; Patient Selection; Research Design | 2011 |
Sputum inflammatory cells and allergen-induced airway responses in allergic asthmatic subjects.
Topics: Allergens; Asthma; Bronchoconstrictor Agents; Eosinophils; Humans; Inflammation; Methacholine Chloride; Sputum | 2011 |
Predictors of airway hyperresponsiveness differ between old and young patients with asthma.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Sectional Studies; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Risk Factors | 2011 |
Sensitivity to environmental irritants and capsaicin cough reaction in patients with a positive methacholine provocation test before and after treatment with inhaled corticosteroids.
Topics: Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Capsaicin; Case-Control Studies; Confidence Intervals; Environmental Pollutants; Female; Follow-Up Studies; Humans; Irritants; Linear Models; Male; Methacholine Chloride; Middle Aged; Prospective Studies; Risk Assessment; Severity of Illness Index; Spirometry; Statistics, Nonparametric; Treatment Outcome; Young Adult | 2011 |
Comparison of bronchial hyperresponsiveness to methacholine and adenosine and airway inflammation markers in patients with suspected asthma.
Topics: Adenosine; Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Biomarkers; Breath Tests; Bronchi; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Eosinophils; Exhalation; Female; Humans; Inflammation; Leukocyte Count; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Sensitivity and Specificity; Sputum; Young Adult | 2011 |
Relationships of methacholine and adenosine 5'-monophosphate (AMP) responsiveness to the postbronchodilator FEV₁/FVC ratio in children with asthma.
Topics: Adenosine Monophosphate; Airway Remodeling; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bronchodilator Agents; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Spirometry; Vital Capacity | 2011 |
Airway refractoriness to inhaled mannitol after repeated challenge.
Topics: Administration, Inhalation; Adolescent; Asthma; Child; Female; Forced Expiratory Volume; Humans; Male; Mannitol; Methacholine Chloride | 2011 |
Predictive factors for airway hyperresponsiveness in children with respiratory symptoms.
Topics: Adolescent; Age Factors; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Cough; Dyspnea; Eosinophilia; Female; Forced Expiratory Volume; Humans; Logistic Models; Male; Methacholine Chloride; Retrospective Studies; Risk Factors | 2011 |
Physical forces and airway remodeling in asthma.
Topics: Asthma; Bronchi; Bronchoconstriction; Eosinophils; Humans; Methacholine Chloride | 2011 |
Relationship between bronchial hyperreactivity and bronchodilation in patients with allergic rhinitis.
Topics: Adult; Albuterol; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Cross-Sectional Studies; Female; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Inflammation; Male; Methacholine Chloride; Middle Aged; Rhinitis, Allergic, Perennial; Risk Factors; Spirometry; Vital Capacity; Young Adult | 2011 |
Evaluation of impulse oscillometry during bronchial challenge testing in children.
Topics: Asthma; Bronchial Provocation Tests; Child; Cough; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Oscillometry; Retrospective Studies; Rhinitis, Allergic, Perennial; ROC Curve; Sensitivity and Specificity | 2011 |
Role of prostaglandin D2 receptor CRTH2 in sustained eosinophil accumulation in the airways of mice with chronic asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Eosinophils; Goblet Cells; Interleukin-13; Interleukin-5; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Mucins; Ovalbumin; Pulmonary Eosinophilia; Receptors, Immunologic; Receptors, Prostaglandin; Vaccination | 2011 |
A single DH gene segment is sufficient for the establishment of an asthma phenotype in a murine model of allergic airway inflammation.
Topics: Allergens; Animals; Asthma; B-Lymphocytes; Bronchial Hyperreactivity; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hypersensitivity; Immunoglobulin E; Immunoglobulin G; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Ovalbumin | 2011 |
Lack of transient receptor potential vanilloid-1 enhances Th2-biased immune response of the airways in mice receiving intranasal, but not intraperitoneal, sensitization.
Topics: Administration, Intranasal; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Immunoglobulin E; Injections, Intraperitoneal; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovalbumin; Pyroglyphidae; Respiratory Hypersensitivity; Th2 Cells; TRPV Cation Channels | 2011 |
Effects of furosemide on allergic asthmatic responses in mice.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Furosemide; Goblet Cells; Hypersensitivity; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; T-Lymphocytes; Treatment Outcome | 2011 |
Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma.
Topics: Animals; Asthma; Bronchoalveolar Lavage; Chemokines; Disease Models, Animal; Gene Expression Regulation; Inflammation; Interferon-gamma; Lung; Mast Cells; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Biological; Oligonucleotide Array Sequence Analysis; Th1 Cells; Th2 Cells | 2011 |
Airway resistance at maximum inhalation as a marker of asthma and airway hyperresponsiveness.
Topics: Adolescent; Airway Resistance; Albuterol; Asthma; Boston; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Case-Control Studies; Female; Forced Expiratory Volume; Humans; Inhalation; Lung; Male; Maximal Midexpiratory Flow Rate; Methacholine Chloride; Predictive Value of Tests; Severity of Illness Index; Spirometry; Vital Capacity; Young Adult | 2011 |
Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation.
Topics: Adult; Asthma; Bariatric Surgery; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; CD4-Positive T-Lymphocytes; Cross-Sectional Studies; Female; Humans; Inflammation; Male; Methacholine Chloride; Middle Aged; Obesity; Prospective Studies; Respiratory Function Tests; Treatment Outcome; Weight Loss | 2011 |
NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Anti-Inflammatory Agents; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cell Fractionation; Cell Separation; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Histamine; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Isoenzymes; Methacholine Chloride; Middle Aged; Muscle Proteins; Myosin-Light-Chain Phosphatase; p38 Mitogen-Activated Protein Kinases; Phosphodiesterase 4 Inhibitors; Phosphoprotein Phosphatases; Pneumonia; Rolipram; Tissue Culture Techniques; Tumor Necrosis Factor-alpha; Vasoconstrictor Agents | 2011 |
Parent-reported ISAAC written questionnaire may underestimate the prevalence of asthma in children aged 10-12 years.
Topics: Adolescent; Asthma; Bronchoconstrictor Agents; Child; Humans; Methacholine Chloride; Parents; Predictive Value of Tests; Prevalence; Reproducibility of Results; Surveys and Questionnaires | 2012 |
Capsicum annuum L. methanolic extract inhibits ovalbumin-induced airway inflammation and oxidative stress in a mouse model of asthma.
Topics: Administration, Oral; Animals; Antioxidants; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Capsicum; Cytokines; Disease Models, Animal; Female; Fruit; Immunoglobulin E; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; NF-kappa B; Ovalbumin; Oxidative Stress; Plant Extracts; Reactive Oxygen Species; T-Lymphocytes, Helper-Inducer | 2011 |
Iron administration reduces airway hyperreactivity and eosinophilia in a mouse model of allergic asthma.
Topics: Allergens; Animals; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eosinophilia; Humans; Immunoglobulin E; Infant; Injections, Intraperitoneal; Iron; Iron-Dextran Complex; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phenanthrolines; Plethysmography | 2011 |
Characterization of the methacholine PC15.
Topics: Asthma; Bronchial Provocation Tests; Forced Expiratory Volume; Humans; Methacholine Chloride; Retrospective Studies | 2011 |
Relationships between airway hyperresponsiveness, inflammation, and calibre in asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Exhalation; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Nitric Oxide; Pneumonia; Regression Analysis; Respiratory Function Tests; Respiratory Hypersensitivity; Retrospective Studies; Severity of Illness Index; Spirometry | 2011 |
Lactobacillus gasseri suppresses Th17 pro-inflammatory response and attenuates allergen-induced airway inflammation in a mouse model of allergic asthma.
Topics: Animals; Antibodies; Antigens, Dermatophagoides; Asthma; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation; Immunoglobulin E; Immunoglobulin G; Inflammation; Lactobacillus; Methacholine Chloride; Mice; Mice, Inbred BALB C; Probiotics; Th17 Cells | 2012 |
Early postnatal exposure of mice to side-steam tobacco smoke increases neuropeptide Y in lung.
Topics: Age Factors; Airway Resistance; Animals; Animals, Newborn; Asthma; Carbazoles; Indole Alkaloids; Methacholine Chloride; Mice; Mice, Inbred ICR; Muscle, Smooth; Nerve Fibers; Nerve Growth Factor; Neuropeptide Y; Protein-Tyrosine Kinases; Tobacco Smoke Pollution; Trachea | 2012 |
Effects of experimental asthma on inflammation and lung mechanics in sickle cell mice.
Topics: Airway Resistance; Anemia, Sickle Cell; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Colorimetry; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eosinophils; Hemoglobin A; Hemoglobin, Sickle; Humans; Immunoglobulin E; Inflammation Mediators; L-Lactate Dehydrogenase; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ovalbumin; Pneumonia; Positive-Pressure Respiration; Vascular Endothelial Growth Factor A | 2012 |
Clinical, physiological and anti-inflammatory effect of montelukast in patients with cough variant asthma.
Topics: Acetates; Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cohort Studies; Cough; Cyclopropanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Leukotriene Antagonists; Linear Models; Male; Methacholine Chloride; Middle Aged; Multivariate Analysis; Odds Ratio; Prospective Studies; Quinolines; Respiratory Function Tests; Risk Assessment; Severity of Illness Index; Sulfides; Treatment Outcome | 2012 |
Hypertrophic airway smooth muscle mass correlates with increased airway responsiveness in a murine model of asthma.
Topics: Airway Resistance; Animals; Apoptosis; Asthma; Cell Proliferation; Disease Models, Animal; Female; Hypertrophy; Methacholine Chloride; Mice; Mice, Inbred BALB C; Muscle, Smooth; Ovalbumin; Respiratory Hypersensitivity | 2012 |
Alcohol reduces airway hyperresponsiveness (AHR) and allergic airway inflammation in mice.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchoconstrictor Agents; Calcitonin Gene-Related Peptide; Cell Count; Cell Line; Cytokines; Eosinophils; Ethanol; Goblet Cells; Immunoglobulin E; Inflammation; Lung; Male; Metaplasia; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; PPAR gamma; Th2 Cells | 2012 |
Validation study of asthma screening criteria based on subjective symptoms and fractional exhaled nitric oxide.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Breath Tests; Bronchial Provocation Tests; Eosinophilia; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Prospective Studies; Reproducibility of Results; Respiratory Function Tests; Sensitivity and Specificity; Sputum; Young Adult | 2011 |
Assessment of peripheral airway function following chronic allergen challenge in a sheep model of asthma.
Topics: Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Separation; Chronic Disease; Disease Models, Animal; Eosinophils; Female; Lung; Methacholine Chloride; Pyroglyphidae; Sheep | 2011 |
Bronchial hyperresponsiveness, word descriptors, and ethnicity: women with mild asthma.
Topics: Adolescent; Adult; Analysis of Variance; Asian People; Asthma; Black or African American; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cohort Studies; Female; Forced Expiratory Volume; Hispanic or Latino; Humans; Methacholine Chloride; Middle Aged; Prognosis; Prospective Studies; Risk Assessment; Severity of Illness Index; Skin Tests; White People; Young Adult | 2012 |
Neonatal epithelial hypoxia inducible factor-1α expression regulates the response of the lung to experimental asthma.
Topics: Airway Resistance; Animals; Animals, Newborn; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cell Count; Cytokines; Eosinophil Major Basic Protein; Eosinophils; Female; Gene Expression; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Immunity, Innate; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Transgenic; Ovalbumin; Random Allocation | 2012 |
IL-33 induces Th17-mediated airway inflammation via mast cells in ovalbumin-challenged mice.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cell Count; Cell Differentiation; Cytokines; Eosinophils; Female; Gene Expression; Inflammation; Interleukin-1 Receptor-Like 1 Protein; Interleukin-33; Interleukins; Lung; Mast Cells; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Ovalbumin; Receptors, Interleukin; Th17 Cells; Th2 Cells | 2012 |
Anti-cholinergic effect of singulair on isolated rat's tracheal smooth muscle.
Topics: Acetates; Animals; Anti-Asthmatic Agents; Asthma; Bronchoconstrictor Agents; Cholinergic Antagonists; Cyclopropanes; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Methacholine Chloride; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Quinolines; Rats; Sulfides; Trachea | 2012 |
Effects of corticosteroid treatment on airway inflammation, mechanics, and hyperpolarized ³He magnetic resonance imaging in an allergic mouse model.
Topics: Adrenal Cortex Hormones; Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchoconstrictor Agents; Dexamethasone; Disease Models, Animal; Elasticity; Helium; Hypersensitivity; Isotopes; Lung; Magnetic Resonance Imaging; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Models, Biological; Ovalbumin; Pulmonary Ventilation; Respiratory Mechanics | 2012 |
Is FENO50 useful diagnostic tool in suspected asthma?
Topics: Adult; Asthma; Breath Tests; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Prospective Studies; ROC Curve; Vital Capacity | 2012 |
Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB.
Topics: Airway Resistance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Adhesion Molecules; Cell Count; Chemokines; Chitinases; Cytokines; Disease Models, Animal; DNA-Binding Proteins; Dose-Response Relationship, Drug; Female; Flavonoids; Flavonols; Genes, Reporter; Inflammation; Inflammation Mediators; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucin 5AC; Mucus; NF-kappa B; Nitric Oxide Synthase Type II; Ovalbumin; Protein Transport; Tumor Necrosis Factor-alpha | 2012 |
Hypoxia response in asthma: differential modulation on inflammation and epithelial injury.
Topics: Airway Remodeling; Animals; Apoptosis; Asthma; Cell Hypoxia; CX3C Chemokine Receptor 1; Hydroxybenzoates; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Procollagen-Proline Dioxygenase; Receptors, Chemokine; Respiratory Mucosa; RNA Interference; RNA, Small Interfering; Signal Transduction | 2012 |
Methacholine challenge in young children as evaluated by spirometry and impulse oscillometry.
Topics: Airway Resistance; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Child, Preschool; Cross-Sectional Studies; Feasibility Studies; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Oscillometry; Spirometry; Vital Capacity | 2012 |
IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction.
Topics: Analysis of Variance; Animals; Asthma; CD11c Antigen; CD4 Antigens; Dendritic Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Humans; In Vitro Techniques; Integrin alphaV; Interleukin-17; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Agonists; Muscle Contraction; Muscle, Smooth; Ovalbumin; Potassium Chloride; Respiratory System; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Th17 Cells | 2012 |
Asthma control test (ACT): comparison with clinical, functional, and biological markers of asthma control.
Topics: Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Adult; Albuterol; Asthma; Biomarkers; Breath Tests; Bronchial Provocation Tests; Eosinophils; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Neutrophils; Nitric Oxide; Peak Expiratory Flow Rate; Sputum; Surveys and Questionnaires | 2012 |
Resting and post bronchial challenge testing carbon dioxide partial pressure in individuals with and without asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Carbon Dioxide; Female; Humans; Male; Methacholine Chloride; Middle Aged; Partial Pressure; Young Adult | 2012 |
The p110δ subunit of PI3K regulates bone marrow-derived eosinophil trafficking and airway eosinophilia in allergen-challenged mice.
Topics: Adenine; Animals; Asthma; Bone Marrow Cells; Cell Adhesion; Cell Movement; Chemokine CCL11; Class I Phosphatidylinositol 3-Kinases; Eosinophilia; Eosinophils; Hypersensitivity; Intercellular Adhesion Molecule-1; Macrophage-1 Antigen; Methacholine Chloride; Mice; Mice, Inbred BALB C; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Respiratory System; RNA Interference; RNA, Small Interfering; Vascular Cell Adhesion Molecule-1 | 2012 |
Spirometry and forced oscillations in the detection of airway hyperreactivity in asthmatic children.
Topics: Adolescent; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Child; Child, Preschool; Female; Histamine; Humans; Male; Methacholine Chloride; Oscillometry; Sensitivity and Specificity; Severity of Illness Index; Spirometry | 2012 |
The tyrosine kinase inhibitor masitinib blunts airway inflammation and improves associated lung mechanics in a feline model of chronic allergic asthma.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Asthma; Benzamides; Bronchoalveolar Lavage Fluid; Cats; Chronic Disease; Cynodon; Eosinophils; Immunoglobulin E; Inflammation; Lung; Male; Methacholine Chloride; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Thiazoles | 2012 |
Utility of fractional exhaled nitric oxide (F(E)NO) measurements in diagnosing asthma.
Topics: Adolescent; Asthma; Breath Tests; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride; Nitric Oxide; Prospective Studies; Sensitivity and Specificity; Skin Tests; Spirometry; Vital Capacity | 2012 |
Integrated effect of EGFR and PAR-1 signaling crosstalk on airway hyperresponsiveness.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; ErbB Receptors; Female; Haplotypes; Humans; Lung; Male; Methacholine Chloride; Polymorphism, Single Nucleotide; Receptor Cross-Talk; Receptor, PAR-1; Young Adult | 2012 |
Discovery of a novel orally active PDE-4 inhibitor effective in an ovalbumin-induced asthma murine model.
Topics: Administration, Oral; Animals; Anti-Asthmatic Agents; Asthma; Benzoates; Bronchial Hyperreactivity; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophil Peroxidase; Female; Ferrets; Guinea Pigs; Inhibitory Concentration 50; Lipopolysaccharides; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phosphodiesterase 4 Inhibitors; Pyrazoles; Rats; Rats, Sprague-Dawley | 2012 |
Population-based study of multiplexed IgE sensitization in relation to asthma, exhaled nitric oxide, and bronchial responsiveness.
Topics: Adult; Allergens; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchial Provocation Tests; Environment; Exhalation; Female; Food Hypersensitivity; Health Surveys; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Pollen; Respiratory Function Tests; Risk Factors; Sweden | 2012 |
Heightened cough response to bronchoconstriction in cough variant asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Adult; Aged; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Cough; Drug Therapy, Combination; Female; Humans; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests; Severity of Illness Index; Young Adult | 2012 |
Relationship of mannitol challenge to methacholine challenge and inflammatory markers in persistent asthmatics receiving inhaled corticosteroids.
Topics: Adrenal Cortex Hormones; Anti-Asthmatic Agents; Asthma; Breath Tests; Bronchial Hyperreactivity; Bronchial Provocation Tests; Eosinophil Cationic Protein; Female; Humans; Male; Mannitol; Methacholine Chloride; Middle Aged; Nitric Oxide; Saliva; Severity of Illness Index | 2012 |
Correlation between eosinophil count and methacholine challenge test in asymptomatic subjects.
Topics: Adolescent; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Eosinophils; Female; Humans; Leukocyte Count; Male; Methacholine Chloride; Neutrophils; Respiratory Function Tests; Retrospective Studies | 2012 |
Deep inhalation bronchoprotection.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cohort Studies; Forced Expiratory Volume; Humans; Inhalation; Methacholine Chloride | 2012 |
Quantitative analysis of dynamic airway changes after methacholine and salbutamol inhalation on xenon-enhanced chest CT.
Topics: Administration, Inhalation; Adult; Aged; Albuterol; Asthma; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Inhalation; Male; Methacholine Chloride; Middle Aged; Respiration; Respiratory Function Tests; Respiratory System; Tomography, X-Ray Computed; Xenon | 2012 |
Methacholine test and the diagnosis of asthma.
Topics: Adrenal Cortex Hormones; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride | 2012 |
Effects of exercise training on airway closure in asthmatics.
Topics: Adult; Asthma; Bronchoconstrictor Agents; Exercise; Exercise Therapy; Female; Forced Expiratory Volume; Humans; Inspiratory Capacity; Male; Methacholine Chloride; Spirometry; Young Adult | 2012 |
Bronchodilator responses after methacholine and adenosine 5'-monophosphate (AMP) challenges in children with asthma: their relationships with eosinophil markers.
Topics: Adenosine Monophosphate; Adolescent; Asthma; Bronchial Provocation Tests; Child; Eosinophil Cationic Protein; Eosinophils; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride | 2012 |
Resistin-like molecule-β is induced following bronchoconstriction of asthmatic airways.
Topics: Adolescent; Adult; Aged; Airway Remodeling; Allergens; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoscopy; Humans; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Methacholine Chloride; Middle Aged; Young Adult | 2012 |
IL-13-induced changes in endogenous glucocorticoid metabolism in the lung regulate the proasthmatic response.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; Asthma; Bronchoconstrictor Agents; Carbenoxolone; Chemokines, CC; Cortisone; Gene Expression; Glucocorticoids; Hydrocortisone; Interleukin-13; Isoenzymes; Lung; Methacholine Chloride; Muscle, Smooth; Pneumonia; Rabbits; Respiratory Mucosa; Trachea | 2012 |
Does bronchial hyperresponsiveness in childhood predict active asthma in adolescence?
Topics: Adolescent; Age Factors; Asthma; Asthma, Exercise-Induced; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Cohort Studies; Disease Progression; Exercise Test; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Methacholine Chloride; Multivariate Analysis; Odds Ratio; Predictive Value of Tests; Prevalence; Prospective Studies; Respiratory Function Tests; Risk Assessment; ROC Curve; Sex Factors; Surveys and Questionnaires; Time Factors | 2012 |
Methacholine is more sensitive than mannitol for evaluation of bronchial hyper-responsiveness in youth athletes with exercise-induced bronchoconstriction.
Topics: Asthma; Bronchial Hyperreactivity; Female; Humans; Male; Mannitol; Methacholine Chloride | 2012 |
Methacholine challenge test as an adjunctive investigative tool in patients with asthma-like symptoms: the Sabah experience.
Topics: Adolescent; Adult; Aged; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Malaysia; Male; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers; Predictive Value of Tests; Spirometry | 2012 |
Airway closure on imaging relates to airway hyperresponsiveness and peripheral airway disease in asthma.
Topics: Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Computer Simulation; Female; Forced Expiratory Volume; Humans; Linear Models; Lung; Lung Volume Measurements; Male; Methacholine Chloride; Middle Aged; Models, Biological; Predictive Value of Tests; Pulmonary Ventilation; Severity of Illness Index; Spirometry; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Vital Capacity; Young Adult | 2012 |
Sputum cell counts and methacholine hyperresponsiveness as asthma outcomes.
Topics: Asthma; Bronchial Provocation Tests; Cell Count; Humans; Methacholine Chloride; Sputum | 2012 |
Regional pulmonary response to a methacholine challenge using hyperpolarized (3)He magnetic resonance imaging.
Topics: Adult; Airway Resistance; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Female; Helium; Humans; Lung; Magnetic Resonance Imaging; Male; Methacholine Chloride; Middle Aged; Pulmonary Ventilation; Respiratory Function Tests; Young Adult | 2012 |
Nebulized anti-IL-13 monoclonal antibody Fab' fragment reduces allergen-induced asthma.
Topics: Administration, Inhalation; Airway Remodeling; Airway Resistance; Allergens; Animals; Anti-Asthmatic Agents; Antibodies, Monoclonal, Murine-Derived; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Immunoglobulin Fab Fragments; Inflammation Mediators; Interleukin-13; Lung; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nebulizers and Vaporizers; Ovalbumin; STAT6 Transcription Factor | 2012 |
Associations between airway hyperresponsiveness, obesity and lipoproteins in a longitudinal cohort.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cholesterol, HDL; Cholesterol, LDL; Cohort Studies; Female; Humans; Lipoproteins; Longitudinal Studies; Male; Methacholine Chloride; Muscle, Smooth; Obesity; Risk Factors; Young Adult | 2013 |
Bronchial inflammation and hyperresponsiveness in well controlled asthma.
Topics: Adolescent; Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Sectional Studies; Eosinophils; Female; Humans; Hypersensitivity, Immediate; Inflammation; Male; Methacholine Chloride; Middle Aged; Neutrophils; Spirometry; Sputum; Young Adult | 2012 |
A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma.
Topics: Amino Alcohols; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cells, Cultured; Chemokine CCL2; Female; Goblet Cells; Humans; Hyperplasia; Immunoglobulin E; Inflammation; Interferon-gamma; Interleukins; Lung; Lysophospholipids; Mast Cells; Methacholine Chloride; Mice; Mice, Inbred C57BL; NF-kappa B; Ovalbumin; Phosphotransferases (Alcohol Group Acceptor); Sphingosine; Tumor Necrosis Factor-alpha | 2013 |
Spleen tyrosine kinase inhibition attenuates airway hyperresponsiveness and pollution-induced enhanced airway response in a chronic mouse model of asthma.
Topics: Air Pollutants; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cells, Cultured; Disease Models, Animal; Female; Humans; Inflammation; Intracellular Signaling Peptides and Proteins; Keratinocytes; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Respiratory Mucosa; Syk Kinase; Vascular Endothelial Growth Factor A | 2013 |
The effect of lung stretch during sleep on airway mechanics in overweight and obese asthma.
Topics: Adolescent; Adult; Aged; Airway Resistance; Analysis of Variance; Asthma; Body Mass Index; Female; Humans; Lung Compliance; Lung Volume Measurements; Male; Methacholine Chloride; Middle Aged; Muscarinic Agonists; Obesity; Overweight; Positive-Pressure Respiration; Sleep; Wakefulness; Young Adult | 2013 |
Variation in airway responsiveness of male C57BL/6 mice from 5 vendors.
Topics: Airway Resistance; Animal Feed; Animals; Animals, Laboratory; Asthma; Breeding; Bronchoconstrictor Agents; Commerce; Disease Models, Animal; Environment; Genetic Variation; Housing, Animal; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Species Specificity | 2012 |
Respiratory syncytial virus reverses airway hyperresponsiveness to methacholine in ovalbumin-sensitized mice.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Female; Melitten; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Receptor, Muscarinic M3; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses | 2012 |
Xenon-enhanced dual-energy CT of patients with asthma: dynamic ventilation changes after methacholine and salbutamol inhalation.
Topics: Administration, Inhalation; Adult; Albuterol; Analysis of Variance; Asthma; Bronchoconstrictor Agents; Bronchodilator Agents; Case-Control Studies; Female; Humans; Male; Methacholine Chloride; Middle Aged; Radiographic Image Interpretation, Computer-Assisted; Respiratory Function Tests; Tomography, X-Ray Computed; Xenon | 2012 |
Increased levels of osteopontin in sputum supernatant of smoking asthmatics.
Topics: Asthma; Bronchial Hyperreactivity; Female; Humans; Inflammation Mediators; Interleukin-13; Interleukin-8; Male; Methacholine Chloride; Middle Aged; Neutrophils; Osteopontin; Respiratory Function Tests; Smoking; Sputum; Transforming Growth Factor beta1 | 2013 |
Effect of the fungal immunomodulatory protein FIP-fve on airway inflammation and cytokine production in mouse asthma model.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Fungal Proteins; Inflammation; Inflammation Mediators; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory System; Th1 Cells; Th2 Cells | 2013 |
Peripheral resistance: a link between global airflow obstruction and regional ventilation distribution.
Topics: Adult; Airway Obstruction; Airway Resistance; Analysis of Variance; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Case-Control Studies; Computer Simulation; Female; Forced Expiratory Volume; Humans; Kinetics; Lung; Male; Methacholine Chloride; Models, Anatomic; Models, Biological; Multidetector Computed Tomography; Positron-Emission Tomography; Pressure; Pulmonary Ventilation; Vital Capacity; Young Adult | 2013 |
The neonatal susceptibility window for inhalant allergen sensitization in the atopically predisposed canine asthma model.
Topics: Administration, Inhalation; Allergens; Ambrosia; Animals; Animals, Newborn; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Desensitization, Immunologic; Dogs; Eosinophilia; Female; Glucosamine; Immune Tolerance; Immunoglobulin E; Immunologic Factors; Inflammation; Methacholine Chloride; Organophosphorus Compounds; Time Factors; Toll-Like Receptor 4 | 2013 |
The DNA methylation inhibitor 5-azacytidine increases regulatory T cells and alleviates airway inflammation in ovalbumin-sensitized mice.
Topics: Animals; Asthma; Azacitidine; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; CD4 Antigens; DNA Methylation; Eosinophilia; Forkhead Transcription Factors; Immunoglobulin E; Immunoglobulin G; Interleukin-13; Interleukin-2 Receptor alpha Subunit; Interleukin-4; Interleukin-5; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory System; Spleen; T-Lymphocytes, Regulatory | 2013 |
CD4+CD25+Foxp3+ T cells contribute to the antiasthmatic effects of Astragalus membranaceus extract in a rat model of asthma.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Astragalus propinquus; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Forkhead Transcription Factors; Male; Methacholine Chloride; Ovalbumin; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; RNA, Messenger; T-Lymphocytes, Regulatory | 2013 |
Dok adaptors play anti-inflammatory roles in pulmonary homeostasis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; DNA-Binding Proteins; Fibrosis; Homeostasis; Hyperplasia; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphoproteins; Pneumonia; Respiratory Mucosa; RNA-Binding Proteins; Th2 Cells | 2013 |
Development of asthmatic inflammation in mice following early-life exposure to ambient environmental particulates and chronic allergen challenge.
Topics: Allergens; Animals; Animals, Newborn; Antioxidants; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Environmental Exposure; Epithelial Cells; Female; Gene Expression Regulation; Immunization; Methacholine Chloride; Mice; Mice, Inbred BALB C; Oxidative Stress; Particulate Matter; Pneumonia; RNA, Messenger; Weaning | 2013 |
Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite.
Topics: Airway Remodeling; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Dendritic Cells; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; GATA3 Transcription Factor; Homeostasis; Hypersensitivity; Inflammation; Interleukin-13; Interleukin-4; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pyroglyphidae; Th2 Cells; Thymic Stromal Lymphopoietin | 2013 |
Bronchial allergen challenges in children - safety and predictors.
Topics: Adolescent; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Child, Preschool; Exhalation; Female; Humans; Hypersensitivity; Immunoglobulin E; Male; Methacholine Chloride; Nitric Oxide; Predictive Value of Tests; Pyroglyphidae; Respiratory Function Tests; Retrospective Studies; ROC Curve; Sensitivity and Specificity | 2013 |
Prophylactic vaccination with adjuvant monophosphoryl lipid a prevents Th2-mediated murine asthmatic responses.
Topics: Adjuvants, Immunologic; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Female; Immunoglobulin E; Interferon-gamma; Interleukin-4; Lipid A; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Statistics, Nonparametric; Th2 Cells | 2013 |
Comparison of changes in lung function measured by plethymography and IOS after bronchoprovocation.
Topics: Adult; Airway Resistance; Allergens; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Oscillometry; Plethysmography, Whole Body; Sensitivity and Specificity; Spirometry; Young Adult | 2013 |
Recurring BALB/c mouse lung inflammatory responses to episodic allergen exposure.
Topics: Aerosols; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Count; Chronic Disease; Collagen; Female; Fibrosis; Inhalation Exposure; Leukocytes; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Monocyte-Macrophage Precursor Cells; Ovalbumin; Recurrence; Respiratory Function Tests; Time Factors | 2013 |
Protocatechuic acid suppresses ovalbumin-induced airway inflammation in a mouse allergic asthma model.
Topics: Administration, Inhalation; Animals; Anti-Asthmatic Agents; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Cytokines; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Hydroxybenzoates; Immunoglobulin E; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Hypersensitivity | 2013 |
Effect of methacholine on peripheral lung mechanics and ventilation heterogeneity in asthma.
Topics: Adolescent; Adult; Aged; Airway Resistance; Analysis of Variance; Asthma; Breath Tests; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Functional Residual Capacity; Humans; Inspiratory Capacity; Lung; Male; Maximal Midexpiratory Flow Rate; Methacholine Chloride; Middle Aged; Oscillometry; Predictive Value of Tests; Pulmonary Ventilation; Respiratory Mechanics; Spirometry; Young Adult | 2013 |
Methacholine PC20 in African Americans and whites with asthma with homozygous genotypes at ADRB2 codon 16.
Topics: Acetates; Adolescent; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Adult; Anti-Asthmatic Agents; Asthma; Black or African American; Bronchial Hyperreactivity; Bronchodilator Agents; Cyclopropanes; Female; Genotype; Histamine Antagonists; Humans; Ipratropium; Male; Methacholine Chloride; Middle Aged; Quinolines; Receptors, Adrenergic, beta-2; Respiratory Function Tests; Sulfides; White People; Young Adult | 2013 |
TLR-2 activation induces regulatory T cells and long-term suppression of asthma manifestations in mice.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Immunoglobulin E; Lipoproteins; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; T-Lymphocytes, Regulatory; Toll-Like Receptor 2 | 2013 |
Supramaximal flow in asthmatic patients.
Topics: Adult; Albuterol; Asthma; Bronchoconstrictor Agents; Bronchodilator Agents; Forced Expiratory Volume; Humans; Methacholine Chloride; Middle Aged; Vital Capacity | 2002 |
Dyspnoea perception during clinical remission of atopic asthma.
Topics: Adenosine Monophosphate; Adult; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cross-Sectional Studies; Dyspnea; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Perception; Remission, Spontaneous | 2002 |
A study of the association between exercise-induced wheeze and exercise versus methacholine-induced bronchoconstriction in adolescents.
Topics: Adolescent; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Bronchoconstriction; Female; Humans; Male; Methacholine Chloride; Nitric Oxide; Respiratory Sounds | 2002 |
Variable FEV1 following methacholine inhalation.
Topics: Administration, Inhalation; Aged; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Methacholine Chloride; Spirometry; Time | 2002 |
Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4).
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchitis; Chemokine CCL11; Chemokines, CC; Eosinophils; Hydroxyeicosatetraenoic Acids; Interleukin-13; Interleukin-5; Leukotrienes; Lipoxins; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Transgenic; Prostaglandins; Receptors, Cell Surface; Receptors, Formyl Peptide; Receptors, Lipoxin | 2002 |
Effect of deep inhalations after a bronchial methacholine provocation in asthmatic and non-asthmatic subjects.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Respiration | 2002 |
Serum eosinophil cationic protein (S-ECP) in a population with low prevalence of atopy.
Topics: Adult; Asthma; Blood Proteins; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Chi-Square Distribution; Eosinophil Granule Proteins; Female; Humans; Hypersensitivity; Immunoglobulin E; Linear Models; Male; Methacholine Chloride; Prevalence; Ribonucleases | 2002 |
Influence of lipopolysaccharide exposure on airway function and allergic responses in developing mice.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cell Count; Cytokines; Dose-Response Relationship, Drug; Endotoxins; Inflammation; Lipopolysaccharides; Lymphocytes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; Reference Values | 2002 |
CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Cell Line; Cytokines; Dose-Response Relationship, Drug; Genetic Therapy; Inflammation; Interleukin-10; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, SCID; Ovalbumin; Protein Engineering; Pulmonary Eosinophilia; T-Lymphocytes, Helper-Inducer; Th2 Cells; Transduction, Genetic | 2002 |
Clinical and immunologic factors associated with the presence or absence of airways hyper-responsiveness in childhood asthma.
Topics: Animals; Animals, Domestic; Asthma; Birth Weight; Breast Feeding; Breath Tests; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cell Adhesion Molecules; Child; Concanavalin A; Female; Glucocorticoids; Humans; Hypersensitivity, Immediate; Interferon-gamma; Interleukin-10; Interleukin-4; Interleukin-5; Leukocytes, Mononuclear; Logistic Models; Lymphocyte Activation; Male; Methacholine Chloride; Nitric Oxide; Respiratory Function Tests; Smoking; Unnecessary Procedures | 2002 |
Predictors of methacholine responsiveness in a general population.
Topics: Adolescent; Adult; Air Pollution; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Reference Values; Respiratory Hypersensitivity; Smoking; Switzerland; Urban Population | 2002 |
Value of a negative aeroallergen skin-prick test result in the diagnosis of asthma in young adults: correlative study with methacholine challenge testing.
Topics: Adolescent; Adult; Algorithms; Allergens; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Female; Humans; Intradermal Tests; Male; Methacholine Chloride; Predictive Value of Tests; Respiratory Hypersensitivity | 2002 |
Gastroesophageal reflux and bronchial responsiveness: correlation and the effect of fundoplication.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Fundoplication; Gastroesophageal Reflux; Humans; Male; Mathematics; Methacholine Chloride; Middle Aged; Severity of Illness Index; Treatment Outcome | 2002 |
Deep breaths, methacholine, and airway narrowing in healthy and mild asthmatic subjects.
Topics: Adult; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Functional Residual Capacity; Humans; Male; Methacholine Chloride; Pulmonary Ventilation; Reference Values; Residual Volume; Respiratory Mechanics; Respiratory Physiological Phenomena; Severity of Illness Index; Time Factors; Vital Capacity | 2002 |
Sputum eosinophil count in a large population of patients with mild to moderate steroid-naive asthma: distribution and relationship with methacholine bronchial hyperresponsiveness.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Eosinophils; Female; Forced Expiratory Volume; Humans; Leukocyte Count; Male; Methacholine Chloride; Middle Aged; Predictive Value of Tests; Prospective Studies; Severity of Illness Index; Sputum; Vital Capacity | 2002 |
Role of tumor necrosis factor in toluene diisocyanate asthma.
Topics: Allergens; Animals; Antigens, CD; Asthma; B7-2 Antigen; Cytokines; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Immunoglobulin E; Immunoglobulin G; Interferon-gamma; Interleukin-4; Lymph Nodes; Membrane Glycoproteins; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Occupational Exposure; Receptors, Tumor Necrosis Factor; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleases; Time Factors; Toluene 2,4-Diisocyanate; Tumor Necrosis Factor-alpha | 2002 |
Risk factors for bronchial hyperresponsiveness in late childhood and early adolescence.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Child, Preschool; Cross-Sectional Studies; Female; Humans; Hypersensitivity; Male; Methacholine Chloride; Prevalence; Prospective Studies; Puberty; Quebec; Residence Characteristics; Risk Factors; Skin Tests | 2002 |
Airway obstruction induced by inhaled acetaldehyde in asthma: repeatability relationship to adenosine 5'-monophosphate responsiveness.
Topics: Acetaldehyde; Adenosine Monophosphate; Administration, Inhalation; Adolescent; Adult; Airway Obstruction; Albuterol; Asthma; Blood Pressure; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Reproducibility of Results; Statistics as Topic | 2002 |
Lower airway inflammatory responses to repeated very-low-dose allergen challenge in allergic rhinitis and asthma.
Topics: Adolescent; Adult; Allergens; Analysis of Variance; Asthma; Bronchoconstrictor Agents; Dose-Response Relationship, Immunologic; Eosinophils; Female; Humans; Immunization Schedule; Male; Methacholine Chloride; Middle Aged; Multivariate Analysis; Rhinitis, Allergic, Perennial; Spirometry; Sputum | 2002 |
Maximal airway response in adolescents with long-term asthma remission and persisting airway hypersensitivity: its profile and the effect of inhaled corticosteroids.
Topics: Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Airway Obstruction; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Budesonide; Case-Control Studies; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Probability; Prognosis; Reference Values; Remission, Spontaneous; Respiratory Function Tests; Sampling Studies; Sensitivity and Specificity; Severity of Illness Index; Statistics, Nonparametric | 2002 |
Handgrip-induced airway dilation in asthmatic patients with bronchoconstriction induced by MCh inhalation.
Topics: Administration, Inhalation; Adult; Airway Resistance; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Cardiovascular System; Control Groups; Female; Hand Strength; Humans; Male; Methacholine Chloride; Norepinephrine; Periodicity; Recovery of Function; Respiratory System; Time Factors | 2002 |
Long-lived Th2 memory in experimental allergic asthma.
Topics: Acute Disease; Aerosols; Animals; Asthma; Bronchial Hyperreactivity; Cytokines; Female; Immunoglobulins; Immunologic Memory; Inflammation; Lung; Lymph Nodes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucus; Ovalbumin; Spleen; Th2 Cells; Time Factors | 2002 |
Dysfunction and remodeling of the mouse airway persist after resolution of acute allergen-induced airway inflammation.
Topics: Actins; Airway Resistance; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage; Bronchoconstriction; Eosinophils; Extracellular Matrix; Female; Inflammation; Interleukin-13; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucins; Muscle, Smooth; Ovalbumin | 2002 |
Effects of bronchial obstruction on lower esophageal sphincter motility and gastroesophageal reflux in patients with asthma.
Topics: Adult; Airway Obstruction; Asthma; Bronchial Diseases; Bronchoconstrictor Agents; Esophageal Motility Disorders; Esophagogastric Junction; Female; Gastroesophageal Reflux; Humans; Male; Methacholine Chloride; Respiratory Function Tests; Risk Factors; Severity of Illness Index | 2002 |
Antiinflammatory effects of genistein, a tyrosine kinase inhibitor, on a guinea pig model of asthma.
Topics: Analysis of Variance; Animals; Asthma; Blotting, Western; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Dexamethasone; Disease Models, Animal; Enzyme Inhibitors; Genistein; Guinea Pigs; Immunohistochemistry; Injections, Intraperitoneal; Male; Methacholine Chloride; Probability; Random Allocation; Reference Values; Trachea; Treatment Outcome | 2003 |
Apparent but not real increase in asthma prevalence during the 1990s.
Topics: Adolescent; Adult; Age Distribution; Aged; Asthma; Bronchial Provocation Tests; Chi-Square Distribution; Child; Female; Humans; Linear Models; Logistic Models; Male; Methacholine Chloride; Middle Aged; Population Surveillance; Prevalence; Probability; Respiratory Function Tests; Risk Factors; Severity of Illness Index; Sex Distribution; Surveys and Questionnaires; United Kingdom | 2002 |
Perception of intrinsic and extrinsic respiratory loads in children with life-threatening asthma.
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Case-Control Studies; Child; Female; Hand Strength; Humans; Male; Methacholine Chloride; Perception; Respiratory Mechanics; Spirometry | 2002 |
Understanding how asthmatics perceive symptom distress during a methacholine challenge.
Topics: Adult; Asthma; Bronchoconstrictor Agents; Cross-Sectional Studies; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Perception | 2002 |
Childhood farm environment and asthma and sensitization in young adulthood.
Topics: Adolescent; Adult; Animals; Animals, Domestic; Antibody Specificity; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Environmental Exposure; Female; Finland; Forced Expiratory Volume; Humans; Immunization; Immunoglobulin E; Male; Methacholine Chloride; Radioallergosorbent Test; Respiratory Function Tests; School Health Services; Severity of Illness Index; Skin Tests; Surveys and Questionnaires | 2002 |
The importance of maximal airway response to methacholine in the prediction of wheezing development in patients with cough-variant asthma.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Child Welfare; Cough; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Korea; Male; Methacholine Chloride; Predictive Value of Tests; Prevalence; Respiratory Sounds; Respiratory System; Risk Factors; Severity of Illness Index | 2002 |
Asthma and asthma-like disorder, a 5-year follow-up study.
Topics: Adolescent; Adult; Aged; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Diagnosis, Differential; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Pulmonary Disease, Chronic Obstructive; Skin Tests | 2002 |
Disruption of L-histidine decarboxylase reduces airway eosinophilia but not hyperresponsiveness.
Topics: Administration, Inhalation; Airway Resistance; Animals; Asthma; Bone Marrow Cells; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eosinophilia; Eosinophils; Histamine; Histidine Decarboxylase; Immunoblotting; Interleukin-5; Leukocyte Count; Lung; Male; Methacholine Chloride; Mice; Mice, Knockout; Ovalbumin; Pulmonary Eosinophilia; Selectins; Time Factors | 2003 |
Relationship between nasal and bronchial responsiveness in perennial allergic rhinitic patients with asthma.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Histamine Release; Humans; Male; Methacholine Chloride; Nasal Mucosa; Nasal Provocation Tests; Rhinitis, Allergic, Perennial | 2002 |
Frequency dependence of respiratory system mechanics during induced constriction in a murine model of asthma.
Topics: Airway Resistance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchoconstrictor Agents; Lung Compliance; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Mechanics | 2003 |
Longitudinal changes in airflow limitation and airway hyperresponsiveness in patients with stable asthma.
Topics: Adult; Airway Obstruction; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Female; Forced Expiratory Volume; Humans; Immunoglobulin E; Japan; Longitudinal Studies; Male; Methacholine Chloride; Middle Aged; Models, Biological; Regression Analysis; Spirometry | 2002 |
Bronchodilator response in asthmatic children is significantly reduced when measured immediately after methacholine challenge.
Topics: Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Child; Child Welfare; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Netherlands; Statistics as Topic; Time Factors; Treatment Outcome | 2002 |
src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation.
Topics: Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; CD4-Positive T-Lymphocytes; Cell Differentiation; Cross-Linking Reagents; Dose-Response Relationship, Drug; Dose-Response Relationship, Immunologic; Enzyme-Linked Immunosorbent Assay; Eosinophils; Flow Cytometry; Heterozygote; Hypersensitivity; Immunoblotting; Inflammation; Interleukin-13; Interleukin-6; Intracellular Signaling Peptides and Proteins; Mast Cells; Methacholine Chloride; Mice; Mice, Inbred C3H; Microscopy, Fluorescence; Mutation; Phenotype; Precipitin Tests; Protein Structure, Tertiary; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Receptors, Interleukin-4; Signal Transduction; src Homology Domains; T-Lymphocytes; Th1 Cells; Th2 Cells; Time Factors | 2003 |
An improved porcine model of stable methacholine-induced bronchospasm.
Topics: Animals; Asthma; Bronchial Spasm; Disease Models, Animal; Methacholine Chloride; Reproducibility of Results; Respiration, Artificial; Respiratory Mechanics; Swine; Ventilation-Perfusion Ratio | 2003 |
[The effect of leukotriene antagonist on the parameters of dose-response curve obtained after methacholine challenge test].
Topics: Adult; Anti-Asthmatic Agents; Area Under Curve; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Female; Humans; Leukotriene Antagonists; Male; Methacholine Chloride; Middle Aged | 2001 |
Metalloproteinase-9 is increased after toluene diisocyanate exposure in the induced sputum from patients with toluene diisocyanate-induced asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Female; Gelatinases; Humans; Irritants; Lung; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Methacholine Chloride; Middle Aged; Occupational Diseases; Sputum; Tissue Inhibitor of Metalloproteinase-1; Toluene 2,4-Diisocyanate | 2003 |
[Measurement of the parameters of dose-response curve obtained after the methacholine challenge test].
Topics: Adult; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Middle Aged; Reference Values; Respiratory Function Tests | 2001 |
Relationship of house-dust mite allergen exposure in children's bedrooms in infancy to bronchial hyperresponsiveness and asthma diagnosis by age 6 to 7.
Topics: Adult; Air Pollution, Indoor; Allergens; Antigens, Dermatophagoides; Arthropod Proteins; Asthma; Bedding and Linens; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child Welfare; Child, Preschool; Cohort Studies; Cysteine Endopeptidases; Environmental Exposure; Female; Fetal Blood; Follow-Up Studies; Humans; Immunoglobulin A; Immunoglobulin E; Infant; Infant Welfare; Infant, Newborn; Male; Maternal Welfare; Methacholine Chloride; Skin Tests; Statistics as Topic | 2003 |
Discriminant analysis in allergic rhinitis and asthma: methacholine dose-response slope allows a good differentiation between mild asthma and rhinitis.
Topics: Adult; Allergens; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dermatophagoides pteronyssinus; Discriminant Analysis; Female; Humans; Male; Methacholine Chloride; Rhinitis, Allergic, Perennial; Sensitivity and Specificity | 2003 |
Enhanced serum neutrophil chemotactic activity was noted in both early and late asthmatic responses during lysine-aspirin bronchoprovocation test in ASA-sensitive asthmatic patients.
Topics: Adult; Aged; Aspirin; Asthma; Bronchial Provocation Tests; Chemotactic Factors; Chemotaxis; Female; Histamine; Humans; Interleukin-8; Lysine; Male; Mast Cells; Methacholine Chloride; Middle Aged; Monocytes; Neutrophils; Time Factors | 2003 |
Treatment of experimental asthma by long-term gene therapy directed against IL-4 and IL-13.
Topics: Animals; Asthma; Dependovirus; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Eosinophils; Female; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Immunohistochemistry; Interleukin-13; Interleukin-4; Methacholine Chloride; Mice; Mice, Inbred BALB C; Plasmids; Receptors, Interleukin-4; Recombinant Proteins; Th2 Cells; Time Factors | 2003 |
A broad-spectrum caspase inhibitor attenuates allergic airway inflammation in murine asthma model.
Topics: Aerosols; Allergens; Amino Acid Chloromethyl Ketones; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Caspase Inhibitors; Cell Movement; Cysteine Proteinase Inhibitors; Disease Models, Animal; Inflammation; Interleukin-4; Interleukin-5; Intubation, Intratracheal; Leukocytes; Lung; Lymphocyte Activation; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; T-Lymphocytes | 2003 |
High prevalence of current asthma and active smoking effect among the elderly.
Topics: Adult; Age Distribution; Aged; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Humans; Hypersensitivity, Immediate; Korea; Logistic Models; Lung; Male; Methacholine Chloride; Middle Aged; Prevalence; Rural Health; Skin Tests; Smoking; Urban Health | 2002 |
Concentrations of exhaled nitric oxide in asthmatics and subjects with allergic rhinitis sensitized to the same pollen allergen.
Topics: Adenosine Monophosphate; Adult; Allergens; Asthma; Breath Tests; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Nitric Oxide; Parietaria; Pollen; Rhinitis, Allergic, Seasonal; Vital Capacity | 2002 |
Dissociation by steroids of eosinophilic inflammation from airway hyperresponsiveness in murine airways.
Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Dexamethasone; Dose-Response Relationship, Drug; Eosinophilia; Immunization; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin | 2003 |
Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma.
Topics: Allergens; Androstadienes; Animals; Asthma; Blood Proteins; Blotting, Western; Bronchoalveolar Lavage Fluid; Cations; Cells, Cultured; Chromones; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eosinophil Granule Proteins; Female; Genetic Vectors; Immunohistochemistry; Inflammation; Interleukin-4; Interleukin-5; Lac Operon; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Morpholines; Phenotype; Phosphatidylinositol 3-Kinases; Phosphoric Monoester Hydrolases; Phosphorylation; PTEN Phosphohydrolase; Ribonucleases; Time Factors; Tumor Suppressor Proteins; Wortmannin | 2003 |
Effect of theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of progenitor cells in bronchial asthma.
Topics: Albuterol; Animals; Antigens, CD34; Apoptosis; Asthma; Cell Division; Female; Humans; Male; Methacholine Chloride; Phosphodiesterase Inhibitors; Rolipram; Stem Cells; Theophylline; Time Factors | 2003 |
The role of L-carnitine in treatment of a murine model of asthma.
Topics: Animals; Asthma; Carnitine; Disease Models, Animal; Leukotriene E4; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Oxygen | 2002 |
Asthma exacerbations and sputum eosinophil counts.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Drug Therapy, Combination; Eosinophils; Humans; Leukocyte Count; Methacholine Chloride; Sputum | 2003 |
Serum interferon-gamma is associated with longitudinal decline in lung function among asthmatic patients: the Normative Aging Study.
Topics: Aged; Aged, 80 and over; Aging; Asthma; Boston; Bronchial Provocation Tests; Cohort Studies; Female; Forced Expiratory Volume; Humans; Interferon-gamma; Interleukin-5; Interleukins; Longitudinal Studies; Lung; Male; Methacholine Chloride; Middle Aged; Prospective Studies; Skin Tests; Smoking; Spirometry; Surveys and Questionnaires; Vital Capacity | 2003 |
Chlorine-induced injury to the airways in mice.
Topics: Administration, Inhalation; Animals; Asthma; Bronchoconstrictor Agents; Chemical Warfare Agents; Chlorine; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Methacholine Chloride; Mice; Respiratory System; Severity of Illness Index; Time Factors | 2003 |
Luteolin alleviates bronchoconstriction and airway hyperreactivity in ovalbumin sensitized mice.
Topics: Airway Resistance; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Expectorants; Flavonoids; Immunoglobulin E; Interferon-gamma; Interleukin-4; Interleukin-5; Luteolin; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Muscarinic Agonists; Ovalbumin | 2003 |
Modulation of airway hyperresponsiveness by thiols in a murine in vivo model of allergic asthma.
Topics: Acetylcysteine; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Expectorants; Glutathione; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Muscarinic Agonists; Ovalbumin; Sulfhydryl Compounds | 2003 |
Exhaled nitric oxide: a useful aide in pediatric asthma management?
Topics: Anti-Asthmatic Agents; Asthma; Bronchoconstrictor Agents; Child, Preschool; Forced Expiratory Volume; Humans; Hypersensitivity; Immunoglobulin E; Infant; Methacholine Chloride; Nitric Oxide; Skin Tests | 2003 |
Effects of helium-oxygen on respiratory mechanics, gas exchange, and ventilation-perfusion relationships in a porcine model of stable methacholine-induced bronchospasm.
Topics: Acute Disease; Animals; Asthma; Bronchial Spasm; Bronchoconstrictor Agents; Disease Models, Animal; Helium; Methacholine Chloride; Oxygen Inhalation Therapy; Pulmonary Gas Exchange; Respiration, Artificial; Respiratory Mechanics; Swine; Treatment Outcome; Ventilation-Perfusion Ratio | 2003 |
Long-term follow-up of toluene diisocyanate-induced asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Female; Follow-Up Studies; Humans; Logistic Models; Longitudinal Studies; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Occupational Diseases; Occupational Exposure; Prognosis; Respiratory Function Tests; Toluene 2,4-Diisocyanate | 2003 |
Persistence of bronchial reactivity to occupational agents after removal from exposure and identification of associated factors.
Topics: Asthma; Bronchi; Bronchial Hyperreactivity; Histamine; Humans; Immunization; Methacholine Chloride; Occupational Diseases; Occupational Exposure | 2003 |
Results of an inner-city school-based asthma and allergy screening pilot study: a combined approach using written questionnaires and step testing.
Topics: Asthma; Child; Exercise Test; Humans; Mass Screening; Methacholine Chloride; Pilot Projects; Predictive Value of Tests; Prevalence; Rhinitis, Allergic, Perennial; Schools; Sensitivity and Specificity; Skin Tests; Spirometry; Surveys and Questionnaires; Texas; Urban Population | 2003 |
Determinants of airway hyperresponsiveness in mild asthma.
Topics: Adult; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Retrospective Studies; Skin Tests; Spirometry | 2003 |
Imaging the lungs in asthmatic patients by using hyperpolarized helium-3 magnetic resonance: assessment of response to methacholine and exercise challenge.
Topics: Adolescent; Adult; Asthma; Bronchoconstrictor Agents; Exercise Test; Helium; Humans; Lung; Magnetic Resonance Imaging; Methacholine Chloride | 2003 |
Absence of deep inspiration-induced bronchoprotection against inhaled allergen.
Topics: Adult; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Inspiratory Capacity; Male; Methacholine Chloride; Middle Aged; Respiratory Mechanics; Rhinitis, Allergic, Perennial; Severity of Illness Index; Skin Tests; Surveys and Questionnaires | 2003 |
Bronchial responsiveness to adenosine-5'-monophosphate and methacholine as predictors for nasal symptoms due to newly introduced allergens. A follow-up study among laboratory animal workers and bakery apprentices.
Topics: Adenosine Monophosphate; Adolescent; Adult; Allergens; Animal Technicians; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Eosinophilia; Female; Flour; Follow-Up Studies; Food Handling; Humans; Male; Methacholine Chloride; Occupational Diseases; Prognosis; Rhinitis; Risk; Skin Tests | 2003 |
Steroid-naive adolescents with mild intermittent allergic asthma have airway hyperresponsiveness and elevated exhaled nitric oxide levels.
Topics: Adolescent; Asthma; Breath Tests; Bronchial Hyperreactivity; Bronchial Provocation Tests; Case-Control Studies; Female; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride; Nitric Oxide; Prevalence; Pyroglyphidae; Respiratory Function Tests; Skin Tests | 2003 |
Assessment of breathlessness perception by Borg scale in asthmatic patients: reproducibility and applicability to different stimuli.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Dyspnea; Female; Humans; Male; Methacholine Chloride; Middle Aged; Perception; Prospective Studies; Reproducibility of Results; Water | 2003 |
Effects of low dose fluticasone/salmeterol combination on surrogate inflammatory markers in moderate persistent asthma.
Topics: Administration, Inhalation; Adolescent; Adult; Aged; Albuterol; Androstadienes; Anti-Asthmatic Agents; Asthma; Beclomethasone; Biomarkers; Blood Proteins; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Budesonide; Chlorofluorocarbons; Dose-Response Relationship, Drug; Drug Therapy, Combination; Eosinophil Granule Proteins; Eosinophils; Fluticasone; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Methacholine Chloride; Middle Aged; Predictive Value of Tests; Ribonucleases; Salmeterol Xinafoate; Severity of Illness Index; Spirometry; Sputum; Treatment Outcome | 2003 |
Rhinoconjunctivitis, bronchial responsiveness, and atopy as determinants for incident non-work-related asthma symptoms in apprentices exposed to high-molecular-weight allergens.
Topics: Adolescent; Adult; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Conjunctivitis, Allergic; Exercise; Female; Follow-Up Studies; Health Personnel; Humans; Hypersensitivity, Immediate; Incidence; Lung; Male; Methacholine Chloride; Molecular Weight; Multivariate Analysis; Occupational Exposure; Prospective Studies; Rhinitis, Allergic, Perennial; Skin Tests; Statistics as Topic; Surveys and Questionnaires | 2003 |
Relationship of airway wall thickness to airway sensitivity and airway reactivity in asthma.
Topics: Adrenergic beta-Agonists; Aged; Airway Resistance; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Beclomethasone; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Eosinophils; Female; Forced Expiratory Volume; Humans; Hyperplasia; Hypertrophy; Inflammation; Leukocyte Count; Male; Methacholine Chloride; Middle Aged; Severity of Illness Index; Sputum; Tomography, X-Ray Computed | 2003 |
Childhood cough variant asthma and its relationship to classic asthma.
Topics: Administration, Inhalation; Adolescent; Age Factors; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Child Welfare; Child, Preschool; Chronic Disease; Cough; Female; Follow-Up Studies; Humans; Infant; Infant Welfare; Male; Methacholine Chloride; Oxygen; Severity of Illness Index; Statistics as Topic; Surveys and Questionnaires | 2003 |
Asthmatic airway inflammation is more closely related to airway hyperresponsiveness to hypertonic saline than to methacholine.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Humans; Male; Methacholine Chloride; Saline Solution, Hypertonic | 2003 |
Lung function in asthma: relation to clinics, challenge tests and immunotherapy.
Topics: Adolescent; Adult; Allergens; Asthma; Bronchial Provocation Tests; Desensitization, Immunologic; Female; Forced Expiratory Volume; Histamine; Humans; Lung; Lung Compliance; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Skin Tests; Treatment Outcome; Vital Capacity | 2003 |
Airway re-narrowing following deep inspiration in asthmatic and nonasthmatic subjects.
Topics: Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Inspiratory Capacity; Linear Models; Male; Methacholine Chloride; Middle Aged; Muscle, Smooth; Spirometry; Tidal Volume | 2003 |
Histamine deficiency in gene-targeted mice strongly reduces antigen-induced airway hyper-responsiveness, eosinophilia and allergen-specific IgE.
Topics: Analysis of Variance; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Chemokines; Cytokines; Data Interpretation, Statistical; Enzyme-Linked Immunosorbent Assay; Eosinophilia; Eosinophils; Female; Gene Expression Profiling; Histamine; Histidine Decarboxylase; Histocytochemistry; Immunization; Immunoglobulin E; Interferon-gamma; Interleukin-4; Leukocyte Count; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Neutrophils; Oligonucleotide Array Sequence Analysis; Ovalbumin; Plethysmography | 2003 |
Polymorphisms in the beta2 adrenergic receptor and bronchodilator response, bronchial hyperresponsiveness, and rate of decline in lung function in smokers.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Genotype; Heterozygote; Humans; Isoproterenol; Lung Diseases; Male; Methacholine Chloride; Middle Aged; Polymorphism, Genetic; Randomized Controlled Trials as Topic; Receptors, Adrenergic, beta-2; Regression Analysis; Smoking | 2003 |
Mycobacterium vaccae administration during allergen sensitization or challenge suppresses asthmatic features.
Topics: Allergens; Animals; Asthma; Bacterial Vaccines; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; Immunoglobulins; Leukocyte Count; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mycobacterium; Ovalbumin; Pulmonary Eosinophilia | 2003 |
Truncating the dose range for methacholine challenge tests: three occupational studies.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Clinical Protocols; Dose-Response Relationship, Drug; Female; Healthy Worker Effect; Humans; Industry; Male; Metallurgy; Methacholine Chloride; Motor Vehicles; Occupational Diseases; United States; Workforce | 2003 |
Linkage and association studies of QTL for nuclear families by mixed models.
Topics: Asthma; Bronchoconstrictor Agents; Child; Female; Genetic Linkage; Humans; Male; Methacholine Chloride; Models, Genetic; Models, Statistical; Nuclear Family; Quantitative Trait Loci | 2003 |
Beta-arrestin-2 regulates the development of allergic asthma.
Topics: Animals; Arrestins; Asthma; beta-Arrestin 2; beta-Arrestins; Bronchoconstrictor Agents; CD3 Complex; CD4 Antigens; CD4-Positive T-Lymphocytes; Cell Membrane; Chemotaxis; Cytokines; Endotoxins; Female; Genotype; Immunoglobulin E; Immunoglobulin G; Inflammation; Lipopolysaccharides; Lung; Lymphocytes; Macrophages; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Transgenic; Protein Structure, Tertiary; T-Lymphocytes; Th2 Cells; Time Factors | 2003 |
Rhinovirus-induced interferon-gamma and airway responsiveness in asthma.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Interferon-gamma; Interleukin-5; Male; Methacholine Chloride; Middle Aged; Rhinovirus | 2003 |
Green tea-induced asthma: relationship between immunological reactivity, specific and non-specific bronchial responsiveness.
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Catechin; Female; Food-Processing Industry; Humans; Male; Methacholine Chloride; Middle Aged; Molecular Weight; Occupational Diseases; Occupational Exposure; Protease Inhibitors; Skin; Skin Tests; Tea | 2003 |
Cardiac arrhythmia monitoring during bronchial provocation test with methacholine.
Topics: Adult; Asthma; Blood Gas Analysis; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cholinergic Agonists; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Male; Methacholine Chloride; Middle Aged; Potassium; Risk Assessment; Tachycardia, Supraventricular; Tachycardia, Ventricular | 2003 |
Bronchial hyperresponsiveness in adolescents with long-term asthma remission: importance of a Family history of bronchial hyperresponsiveness.
Topics: Adolescent; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Genetic Predisposition to Disease; Humans; Male; Methacholine Chloride; Remission Induction; Risk Factors | 2003 |
Nitric oxide and vasoactive intestinal peptide as co-transmitters of airway smooth-muscle relaxation: analysis in neuronal nitric oxide synthase knockout mice.
Topics: Airway Resistance; Animals; Asthma; Culture Techniques; Dose-Response Relationship, Drug; Methacholine Chloride; Mice; Mice, Inbred C57BL; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Reference Values; Trachea; Vasoactive Intestinal Peptide | 2003 |
Airway reactivity and diving in healthy and atopic subjects.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Diving; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride | 2003 |
METHACHOLINE AEROSOL AS TEST FOR BRONCHIAL ASTHMA.
Topics: Adolescent; Aerosols; Anaphylaxis; Asthma; Bronchiectasis; Bronchitis; Child; Geriatrics; Humans; Hyperventilation; Lung Diseases; Methacholine Chloride; Methacholine Compounds; Pharmacology; Pulmonary Emphysema; Respiratory Function Tests; Respiratory Tract Infections; Rhinitis, Allergic, Seasonal | 1965 |
Validity of methods to predict the respiratory sensitizing potential of chemicals: A study with a piperidinyl chlorotriazine derivative that caused an outbreak of occupational asthma.
Topics: Adjuvants, Immunologic; Administration, Cutaneous; Allergens; Animals; Asthma; Bronchoalveolar Lavage; Dermatitis, Allergic Contact; Dose-Response Relationship, Drug; Female; Immunoglobulin E; Local Lymph Node Assay; Lung; Lymph Nodes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Occupational Exposure; Oxazolone; Piperidines; Predictive Value of Tests; Structure-Activity Relationship; Toluene 2,4-Diisocyanate; Triazines | 2003 |
Mechanical stretch activates nuclear factor-kappaB, activator protein-1, and mitogen-activated protein kinases in lung parenchyma: implications in asthma.
Topics: Animals; Asthma; Bronchoconstrictor Agents; Culture Techniques; DNA; Enzyme Activation; Free Radicals; I-kappa B Kinase; I-kappa B Proteins; Lung; Macromolecular Substances; Membrane Transport Proteins; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NF-kappa B; NF-KappaB Inhibitor alpha; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Stress, Mechanical; Transcription Factor AP-1 | 2003 |
Absence of association of peripheral blood eosinophilia or increased eosinophil cationic protein with bronchial hyperresponsiveness during asthma remission.
Topics: Adolescent; Asthma; Blood Proteins; Bronchial Hyperreactivity; Bronchial Provocation Tests; Eosinophil Granule Proteins; Eosinophils; Female; Humans; Leukocyte Count; Male; Methacholine Chloride; Remission, Spontaneous; Ribonucleases | 2003 |
Development of a methacholine challenge method to minimize methacholine waste.
Topics: Adult; Asthma; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Middle Aged | 2003 |
The perception of dyspnea after bronchoconstriction and bronchodilation in patients with asthma.
Topics: Adrenergic beta-2 Receptor Antagonists; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Dyspnea; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Perception | 2003 |
Airway inflammation after cessation of exposure to agents causing occupational asthma.
Topics: Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Cohort Studies; Female; Follow-Up Studies; Humans; Inflammation; Inflammation Mediators; Interleukin-8; Logistic Models; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Occupational Exposure; Peroxidase; Probability; Respiratory Function Tests; Risk Assessment; Sampling Studies; Sputum; Time Factors | 2004 |
Exhaled nitric oxide as a simple assessment of airway hyperresponsiveness in bronchial asthma and chronic cough patients.
Topics: Adult; Asthma; Breath Tests; Bronchial Hyperreactivity; Bronchial Provocation Tests; Case-Control Studies; Chronic Disease; Cough; Female; Humans; Luminescent Measurements; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Spirometry | 2003 |
International Study of Asthma and Allergies in Childhood (ISAAC), in conjunction with step testing is not adequate as a screening for asthma.
Topics: Asthma; Child; Exercise Test; Humans; Mass Screening; Methacholine Chloride; Surveys and Questionnaires; Urban Population | 2003 |
Allergen-specific IgG and IgA in serum and bronchoalveolar lavage fluid in a model of experimental feline asthma.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cat Diseases; Cats; Cynodon; Enzyme-Linked Immunosorbent Assay; Immunoglobulin A; Immunoglobulin G; Methacholine Chloride; Respiratory Function Tests | 2003 |
Opposing effects of short- and long-term stress on airway inflammation.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cytokines; Inflammation; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mifepristone; Receptors, Steroid; Stress, Physiological | 2004 |
Nasal inflammation and bronchial reactivity to methacholine in atopic children with respiratory symptoms.
Topics: Adolescent; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Child, Preschool; Conjunctivitis, Allergic; Eosinophils; Female; Humans; Immunoglobulin E; Inflammation; Intercellular Adhesion Molecule-1; Male; Methacholine Chloride; Nasal Mucosa; Pyroglyphidae; Respiratory Mechanics; Rhinitis, Allergic, Perennial; Skin Tests | 2003 |
Recall helper T cell response: T helper 1 cell-resistant allergic susceptibility without biasing uncommitted CD4 T cells.
Topics: Animals; Antigens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; CD4 Antigens; CD4-Positive T-Lymphocytes; Disease Models, Animal; Eosinophils; Female; Flow Cytometry; Genetic Predisposition to Disease; Hypersensitivity, Immediate; Immune Tolerance; Inflammation; Methacholine Chloride; Mice; Mice, Inbred BALB C; Receptors, Interleukin-2; Th1 Cells; Th2 Cells | 2004 |
Effect of ascorbic acid on airway responsiveness in ovalbumin sensitized guinea pigs.
Topics: Analysis of Variance; Animals; Antioxidants; Ascorbic Acid; Asthma; Bronchial Hyperreactivity; Drug Administration Schedule; Guinea Pigs; Male; Methacholine Chloride; Ovalbumin; Trachea | 2003 |
Exhaled nitric oxide continues to reflect airway hyperresponsiveness and disease activity in inhaled corticosteroid-treated adult asthmatic patients.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Aged; Anti-Asthmatic Agents; Asthma; Beclomethasone; Biomarkers; Bronchial Hyperreactivity; Cross-Sectional Studies; Drug Monitoring; Eosinophils; Female; Humans; Linear Models; Male; Methacholine Chloride; Middle Aged; Multivariate Analysis; Nitric Oxide; Severity of Illness Index; Sputum; Statistics, Nonparametric | 2003 |
Sputum CD34+IL-5Ralpha+ cells increase after allergen: evidence for in situ eosinophilopoiesis.
Topics: Allergens; Analysis of Variance; Antigens, CD34; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Eosinophils; Flow Cytometry; Forced Expiratory Volume; Hematopoiesis; Hematopoietic Stem Cells; Humans; Hypersensitivity, Immediate; Interleukin-5; Leukocyte Count; Methacholine Chloride; Pulmonary Eosinophilia; Respiratory Hypersensitivity; Sputum; Time Factors | 2004 |
Site of inflammation influences site of hyperresponsiveness in experimental asthma.
Topics: Aerosols; Animals; Asthma; Bronchi; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Inflammation; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Function Tests; Respiratory Hypersensitivity; Time Factors; Vascular Resistance | 2003 |
Airway responsiveness after acute exposure to urban particulate matter 1648 in a DO11.10 murine model.
Topics: Air Pollutants; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Transgenic; Ovalbumin; Respiratory Hypersensitivity | 2004 |
Provocation with adenosine 5'-monophosphate, but not methacholine, induces sputum eosinophilia.
Topics: Adenosine Monophosphate; Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Eosinophilia; Female; Glucocorticoids; Humans; Male; Methacholine Chloride; Sputum; Statistics, Nonparametric | 2004 |
Lung function, bronchial responsiveness, and asthma in a community cohort of 6-year-old children.
Topics: Age Factors; Asthma; Australia; Body Height; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Child; Cohort Studies; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Multivariate Analysis; Reference Values; Regression Analysis; ROC Curve; Sensitivity and Specificity; Sex Factors; Spirometry | 2004 |
Relating maximum airway dilation and subsequent reconstriction to reactivity in human lungs.
Topics: Adult; Airway Resistance; Asthma; Bronchi; Bronchoconstriction; Bronchoconstrictor Agents; Case-Control Studies; Female; Humans; Inhalation; Lung Compliance; Male; Methacholine Chloride; Respiratory Mechanics; Total Lung Capacity | 2004 |
Adoptive transfer of alveolar macrophages abrogates bronchial hyperresponsiveness.
Topics: Adoptive Transfer; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Clodronic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Genetic Predisposition to Disease; Immunoglobulin E; Immunoglobulin G; Liposomes; Macrophages, Alveolar; Male; Methacholine Chloride; Ovalbumin; Rats; Rats, Sprague-Dawley; Reaction Time | 2004 |
Exaggerated bronchoconstriction due to inhalation challenges with occupational agents.
Topics: Administration, Inhalation; Air Pollutants, Occupational; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Dust; Flour; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Isocyanates; Methacholine Chloride; Occupational Diseases; Predictive Value of Tests; Retrospective Studies | 2004 |
Expression of nitric oxide synthase-2 in the lungs decreases airway resistance and responsiveness.
Topics: Airway Resistance; Animals; Asthma; Blotting, Northern; Blotting, Western; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; DNA, Complementary; Doxycycline; Immunohistochemistry; Lung; Methacholine Chloride; Mice; Mice, Transgenic; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Respiratory Mechanics; Respiratory Mucosa; Reverse Transcriptase Polymerase Chain Reaction; Tetracycline; Trans-Activators; Transgenes; Uteroglobin | 2004 |
Inhibition of stem cell factor reduces pulmonary cytokine levels during allergic airway responses.
Topics: Allergens; Animals; Antibodies, Monoclonal; Asthma; Chemokines; Chloride Channels; Cytokines; Eosinophilia; Lung; Methacholine Chloride; Mice; Mice, Inbred CBA; Mucoproteins; Stem Cell Factor | 2004 |
(S,S)-formoterol increases the production of IL-4 in mast cells and the airways of a murine asthma model.
Topics: Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Disease Models, Animal; Ethanolamines; Formoterol Fumarate; Histamine Release; Histocytochemistry; Humans; Interleukin-4; Jurkat Cells; Lung; Male; Mast Cells; Methacholine Chloride; Mice; Mice, Inbred BALB C; Prostaglandin D2; Stereoisomerism; T-Lymphocytes | 2004 |
The diagnosis of asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Airway Obstruction; Asthma; Bronchodilator Agents; Diagnostic Errors; Humans; Methacholine Chloride; Spirometry | 2004 |
Overdiagnosis of asthma in the community.
Topics: Adrenal Cortex Hormones; Adult; Asthma; Community Health Services; Diagnostic Errors; Female; Humans; Male; Methacholine Chloride; Nova Scotia; Prevalence; Respiratory Function Tests; Spirometry | 2004 |
Proximal airway mucous cells of ovalbumin-sensitized and -challenged Brown Norway rats accumulate the neuropeptide calcitonin gene-related peptide.
Topics: Allergens; Animals; Asthma; Bronchoconstrictor Agents; Calcitonin Gene-Related Peptide; Cell Division; Deoxyuridine; Eosinophils; Male; Methacholine Chloride; Microscopy, Confocal; Mucins; Ovalbumin; Rats; Rats, Inbred BN; Respiratory Mucosa; Thymidine | 2004 |
Recovery of methacholine responsiveness after end of exposure in occupational asthma.
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Inhalation Exposure; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Occupational Exposure; Predictive Value of Tests; Recovery of Function; Sex Factors | 2004 |
Bronchial hyperresponsiveness to methacholine is associated with increased common carotid intima-media thickness in men.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; C-Reactive Protein; Carotid Artery, Common; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Inflammation; Male; Methacholine Chloride; Middle Aged; Sex Factors; Single-Blind Method; Smoking; Tunica Intima | 2004 |
Respiratory response to toluene diisocyanate depends on prior frequency and concentration of dermal sensitization in mice.
Topics: Administration, Intranasal; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Dermatitis, Allergic Contact; Disease Models, Animal; Immunoglobulin E; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Occupational Exposure; Plethysmography, Whole Body; Respiratory Mechanics; Toluene 2,4-Diisocyanate | 2004 |
Geographic and gender variability in the prevalence of bronchial responsiveness in Canada.
Topics: Adult; Asthma; Bronchi; Bronchoconstrictor Agents; Canada; Female; Humans; Male; Methacholine Chloride; Prevalence; Sex Factors | 2004 |
Irritable bowel syndrome and bronchial hyperresponsiveness: is there a link?
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Humans; Irritable Bowel Syndrome; Male; Methacholine Chloride; Prevalence; Prospective Studies; Stress, Psychological | 2004 |
Acute and chronic changes of vascular endothelial growth factor (VEGF) in induced sputum of toluene diisocyanate (TDI)-induced asthma patients.
Topics: Adult; Asthma; Bronchi; Enzyme-Linked Immunosorbent Assay; Exercise; Humans; Methacholine Chloride; Middle Aged; Placebos; Sputum; Time Factors; Toluene 2,4-Diisocyanate; Vascular Endothelial Growth Factor A | 2004 |
Greater involvement of neurokinins found in Guinea pig models of severe asthma compared with mild asthma.
Topics: Administration, Inhalation; Airway Resistance; Allergens; Animals; Asthma; Biomarkers; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Capsaicin; Disease Models, Animal; Eosinophils; Guinea Pigs; Lung; Male; Methacholine Chloride; Neprilysin; Neurokinin A; Respiratory Hypersensitivity; Severity of Illness Index; Substance P | 2004 |
Oscillation mechanics of the human lung periphery in asthma.
Topics: Adult; Airway Resistance; Asthma; Bronchoconstrictor Agents; Bronchoscopy; Case-Control Studies; Dose-Response Relationship, Drug; Elasticity; Female; Humans; Lung; Lung Compliance; Male; Methacholine Chloride; Models, Biological; Respiratory Mechanics | 2004 |
Effect of intranasal triamcinolone acetonide on bronchial hyper-responsiveness in children with seasonal allergic rhinitis and comparison of perceptional nasal obstruction with acoustic rhinometric assessment.
Topics: Administration, Intranasal; Adolescent; Allergens; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Case-Control Studies; Child; Female; Humans; Immunosuppressive Agents; Male; Methacholine Chloride; Nasal Obstruction; Pollen; Respiratory Function Tests; Rhinitis, Allergic, Seasonal; Rhinometry, Acoustic; Spirometry; Triamcinolone Acetonide | 2004 |
[Studies on airway hyperresponsiveness by the Astograph(r) method in asthmatics and young adult non-asthmatic asymptomatics].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Bronchial Hyperreactivity; Female; Humans; Male; Methacholine Chloride; Middle Aged | 2004 |
Adenosine 5'-monophosphate increases levels of leukotrienes in breath condensate in asthma.
Topics: Adenosine Monophosphate; Adult; Asthma; Biomarkers; Breath Tests; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cysteine; Female; Forced Expiratory Volume; Histamine Release; Humans; Inflammation Mediators; Leukotrienes; Male; Methacholine Chloride; Vital Capacity | 2004 |
Inhibition of murine allergic airway disease by Bordetella pertussis.
Topics: Animals; Asthma; Bordetella pertussis; Bronchoconstrictor Agents; DNA, Bacterial; Down-Regulation; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Ovalbumin; Pertussis Vaccine; Pulmonary Eosinophilia; Respiratory Hypersensitivity; Th1 Cells; Th2 Cells | 2004 |
Effects of primary and secondary low-grade respiratory syncytial virus infections in a murine model of asthma.
Topics: Animals; Antigens, Dermatophagoides; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Interferon-gamma; Interleukin-5; Lung; Lymph Nodes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Models, Animal; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes | 2004 |
alpha-Lipoic acid inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; DNA; Immunoglobulin E; Inflammation; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; NF-kappa B; Oxidative Stress; Thioctic Acid | 2004 |
Heterogeneity of narrowing in normal and asthmatic airways measured by HRCT.
Topics: Adult; Airway Resistance; Analysis of Variance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Case-Control Studies; Humans; Image Interpretation, Computer-Assisted; Lung Volume Measurements; Male; Methacholine Chloride; Middle Aged; Probability; Reference Values; Respiratory Function Tests; Tomography, X-Ray Computed | 2004 |
Sputum eosinophil counts and eosinophil cationic protein levels in cough-variant asthma and in classic asthma, and their relationships to airway hypersensitivity or maximal airway response to methacholine.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Cough; Dose-Response Relationship, Drug; Eosinophil Cationic Protein; Eosinophils; Female; Forced Expiratory Volume; Humans; Leukocyte Count; Male; Methacholine Chloride; Sputum | 2004 |
Involvement of enhanced neurokinin NK3 receptor expression in the severe asthma guinea pig model.
Topics: Animals; Asthma; Benzamides; Binding, Competitive; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Lung; Male; Methacholine Chloride; Neurokinin B; Ovalbumin; Peptide Fragments; Piperidines; Receptors, Neurokinin-3; Substance P; Tritium | 2004 |
Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma.
Topics: Animals; Asthma; B-Lymphocytes; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Complement C5a; Disease Models, Animal; Female; Haptens; Immunization; Immunoglobulin M; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Respiratory Function Tests; Respiratory System | 2004 |
The effect of dihydroergocornine on the pulmonary response to methacholine and histamine in subjects with bronchial asthma.
Topics: Asthma; Choline; Dihydroergocornine; Ergot Alkaloids; Histamine; Humans; Methacholine Chloride | 1950 |
ACTH therapy in bronchial asthma; histamine and methacholine tolerance in the acute experiment and during prolonged treatment.
Topics: Adrenocorticotropic Hormone; Asthma; Choline; Drug Tolerance; Histamine; Humans; Immune Tolerance; Methacholine Chloride | 1950 |
[Association between the forced midexpiratory flow/forced vital capacity ratio and bronchial hyperresponsiveness].
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchitis, Chronic; Confidence Intervals; Cross-Sectional Studies; Dyspnea; Female; Forced Expiratory Flow Rates; Humans; Immunoglobulin E; Male; Methacholine Chloride; Odds Ratio; Skin Tests; Smoking; Spirometry; Surveys and Questionnaires; Vital Capacity | 2004 |
Methacholine and macrolides.
Topics: Anti-Inflammatory Agents; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Clarithromycin; Humans; Macrolides; Methacholine Chloride | 2004 |
Increased levels of IgG to cytokeratin 19 in sera of patients with toluene diisocyanate-induced asthma.
Topics: Adult; Allergens; Antibody Specificity; Asthma; Autoantibodies; Autoantigens; Bronchi; Bronchial Provocation Tests; Cell Line, Transformed; Cells, Cultured; Coculture Techniques; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Female; Gene Expression Profiling; Humans; Immunoconjugates; Immunoglobulin E; Immunoglobulin G; Keratins; Male; Methacholine Chloride; Middle Aged; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Serum Albumin; Toluene 2,4-Diisocyanate | 2004 |
Monitoring the adjustment of antiasthma medications with adenosine monophosphate bronchoprovocation.
Topics: Adenosine Monophosphate; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Forced Expiratory Volume; Humans; Methacholine Chloride; Monitoring, Physiologic | 2004 |
Pulmonary outcome in adolescents of extreme preterm birth: a regional cohort study.
Topics: Adolescent; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchopulmonary Dysplasia; Cohort Studies; Female; Forced Expiratory Volume; Humans; Infant, Newborn; Infant, Premature; Infant, Very Low Birth Weight; Lung; Lung Diseases, Obstructive; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Plethysmography; Prevalence; Spirometry | 2004 |
Comparative cutoff points for adenosine monophosphate and methacholine challenge testing.
Topics: Acetates; Adenosine Monophosphate; Administration, Inhalation; Adrenal Cortex Hormones; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cyclopropanes; Forced Expiratory Volume; Humans; Methacholine Chloride; Quinolines; Retrospective Studies; Sulfides | 2004 |
The links between allergen skin test sensitivity, airway responsiveness and airway response to allergen.
Topics: Adult; Allergens; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Hypersensitivity; Male; Methacholine Chloride; Models, Biological; Retrospective Studies; Skin Tests | 2005 |
Airway reactivity is a determinant of bronchodilator responsiveness after methacholine-induced bronchoconstriction.
Topics: Administration, Inhalation; Adolescent; Adult; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Ipratropium; Linear Models; Male; Metaproterenol; Methacholine Chloride; Middle Aged; Probability; Respiratory Function Tests; Retrospective Studies; Sensitivity and Specificity; Severity of Illness Index; Treatment Outcome | 2004 |
Fractional exhaled nitric oxide (FENO), lung function and airway hyperresponsiveness in naïve atopic asthmatic children.
Topics: Adolescent; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Exhalation; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Nitric Oxide; Predictive Value of Tests; Probability; Prognosis; Respiratory Function Tests; Sampling Studies; Sensitivity and Specificity; Severity of Illness Index | 2004 |
Omalizumab and changes in airway hyperresponsiveness.
Topics: Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Humans; Immunoglobulin E; Inflammation; Methacholine Chloride; Omalizumab | 2005 |
Mucosal symptoms elicited by fragrance products in a population-based sample in relation to atopy and bronchial hyper-reactivity.
Topics: Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Case-Control Studies; Chi-Square Distribution; Eosinophil Cationic Protein; Eye; Eye Diseases; Forced Expiratory Volume; Humans; Methacholine Chloride; Mucous Membrane; Multiple Chemical Sensitivity; Perfume; Skin Tests | 2005 |
Variants in the vitamin D receptor gene and asthma.
Topics: Asthma; Bronchial Hyperreactivity; DNA Mutational Analysis; Family Health; Humans; Inheritance Patterns; Methacholine Chloride; Molecular Epidemiology; Pedigree; Polymorphism, Single Nucleotide; Receptors, Calcitriol | 2005 |
Parasympathetic airway response and heart rate variability before and at the end of methacholine challenge.
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Heart; Heart Rate; Humans; Male; Methacholine Chloride; Middle Aged; Parasympathetic Nervous System; Parasympathomimetics | 2005 |
Deep inspiration avoidance and methacholine response in normal subjects and patients with asthma.
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Spirometry | 2005 |
A new mouse model of lung allergy induced by the spores of Alternaria alternata and Cladosporium herbarum molds.
Topics: Alternaria; Animals; Ascomycota; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Chemokines; Eosinophils; Female; Leukocytes; Lung; Lung Diseases, Fungal; Methacholine Chloride; Mice; Mice, Inbred BALB C; Models, Animal; Receptors, Chemokine; RNA, Messenger | 2005 |
Circulating adhesion molecules in allergic and non-allergic asthma.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cell Adhesion Molecules; E-Selectin; Female; Forced Expiratory Volume; Humans; Intercellular Adhesion Molecule-1; Male; Methacholine Chloride; Middle Aged; Respiratory Hypersensitivity; Vascular Cell Adhesion Molecule-1; Vital Capacity | 2005 |
Latex allergen exposure increases exhaled nitric oxide in symptomatic healthcare workers.
Topics: Adult; Asthma; Chi-Square Distribution; Exhalation; Female; Health Personnel; Humans; Latex; Latex Hypersensitivity; Male; Methacholine Chloride; Nitric Oxide; Occupational Diseases; Occupational Exposure; Respiratory Function Tests; Sensitivity and Specificity; Skin Tests; Statistics, Nonparametric | 2005 |
A guinea pig model for cough variant asthma and role of tachykinins.
Topics: Airway Resistance; Allergens; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchodilator Agents; Capsaicin; Cough; Disease Models, Animal; Guinea Pigs; Male; Methacholine Chloride; Ovalbumin; Peptides, Cyclic; Procaterol; Tachykinins | 2004 |
Dosimeter: what is the dose?
Topics: Asthma; Humans; Methacholine Chloride; Nebulizers and Vaporizers; Respiratory Function Tests | 2005 |
Importance of dosimeter calibration method on nebulizer output.
Topics: Adult; Asthma; Calibration; Humans; Methacholine Chloride; Nebulizers and Vaporizers; Prospective Studies; Respiratory Function Tests | 2005 |
The use of sterically stabilized liposomes to treat asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Bronchodilator Agents; Budesonide; Child; Eosinophil Peroxidase; Humans; Immunoglobulin E; Liposomes; Lung; Methacholine Chloride; Mice | 2005 |
Dose-dependent allergic responses to an extract of Penicillium chrysogenum in BALB/c mice.
Topics: Allergens; Animals; Antigens, Fungal; Asthma; Bronchoalveolar Lavage Fluid; Dose-Response Relationship, Immunologic; Female; Humans; Hypersensitivity; Immunoglobulin E; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Penicillium chrysogenum | 2005 |
Histamine and indirect bronchoprovocation with adenosine monophosphate in asthma.
Topics: Adenosine Monophosphate; Asthma; Breath Tests; Bronchodilator Agents; Cysteine; Histamine; Humans; Leukotrienes; Methacholine Chloride | 2005 |
Methacholine challenge: comparison of two methods.
Topics: Adult; Aged; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Total Lung Capacity | 2005 |
Prenatal lipopolysaccharide-exposure prevents allergic sensitization and airway inflammation, but not airway responsiveness in a murine model of experimental asthma.
Topics: Animals; Animals, Newborn; Antibodies, Monoclonal; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Environmental Exposure; Female; Immunoglobulin G; Immunologic Factors; Injections, Intraperitoneal; Interferon-gamma; Lipopolysaccharides; Maternal-Fetal Exchange; Methacholine Chloride; Mice; Mice, Inbred BALB C; Models, Animal; Ovalbumin; Pregnancy; Prenatal Exposure Delayed Effects | 2005 |
PPAR-gamma modulates allergic inflammation through up-regulation of PTEN.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Female; Gene Expression; Gene Expression Regulation; Interleukin-13; Interleukin-4; Interleukin-5; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phosphatidylinositol 3-Kinases; Phosphorylation; Pioglitazone; PPAR gamma; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; Rosiglitazone; Thiazolidinediones; Trachea; Transfection | 2005 |
Peak expiratory flow variability and exercise responsiveness in methacholine-hyperresponsive adolescents with asthma remission.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Exercise Tolerance; Humans; Methacholine Chloride; Peak Expiratory Flow Rate; Remission, Spontaneous | 2005 |
Respiratory morbidity in office workers in a water-damaged building.
Topics: Adult; Allergens; Asthma; Facility Design and Construction; Female; Humans; Male; Methacholine Chloride; Morbidity; New England; Quality of Life; Respiration Disorders; Skin Tests; Spirometry; Surveys and Questionnaires; Workplace | 2005 |
Rapid onset of tolerance to beta-agonist bronchodilation.
Topics: Adrenergic beta-Agonists; Adult; Albuterol; Analysis of Variance; Area Under Curve; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Dose-Response Relationship, Drug; Drug Tolerance; Ethanolamines; Female; Forced Expiratory Volume; Formoterol Fumarate; Humans; Male; Methacholine Chloride; Middle Aged; Time Factors | 2005 |
Recovery time following bronchial challenge.
Topics: Adrenergic beta-Agonists; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Humans; Methacholine Chloride; Time Factors | 2005 |
Exhaled nitric oxide in the diagnosis of asthma: comparison with bronchial provocation tests.
Topics: Adenosine Monophosphate; Adult; Asthma; Breath Tests; Bronchial Provocation Tests; Bronchoconstrictor Agents; Exercise Test; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Nitric Oxide; Retrospective Studies; Statistics, Nonparametric; Vital Capacity | 2005 |
Different profiles of T-cell IFN-gamma and IL-12 in allergen-induced early and dual responders with asthma.
Topics: Allergens; Asthma; Bronchial Provocation Tests; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Flow Cytometry; Humans; Interferon-gamma; Interleukin-12; Lymphocyte Count; Methacholine Chloride; Sputum; Time Factors | 2005 |
Predictors for typical asthma onset from cough variant asthma.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cough; Eosinophils; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Middle Aged; Predictive Value of Tests; Prospective Studies; Risk Factors; Spirometry | 2005 |
Rhinitis and asthma co-morbidity in respiratory allergy due to house dust mite: results of an observational open controlled parallel group study in real-life setting.
Topics: Adolescent; Adult; Animals; Anti-Allergic Agents; Asthma; Bronchial Provocation Tests; Child; Combined Modality Therapy; Comorbidity; Desensitization, Immunologic; Disease Progression; Drug Hypersensitivity; Female; Follow-Up Studies; Humans; Incidence; Infections; Italy; Male; Methacholine Chloride; Middle Aged; Pyroglyphidae; Respiratory Function Tests; Respiratory Hypersensitivity; Rhinitis, Allergic, Perennial; Severity of Illness Index | 2005 |
Effect of salbutamol on pulmonary responsiveness in chronic pulmonary allergic inflammation in guinea pigs.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Asthma; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Guinea Pigs; Male; Methacholine Chloride; Ovalbumin; Time Factors | 2005 |
Protection from experimental asthma by an endogenous bronchodilator.
Topics: Adrenergic beta-Agonists; Alcohol Dehydrogenase; Allergens; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchodilator Agents; Female; Glutathione Reductase; Homeostasis; Imines; Isoproterenol; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Ovalbumin; S-Nitrosoglutathione; S-Nitrosothiols; Trachea | 2005 |
Effects of corticosteroid on the expression of thymus and activation-regulated chemokine in a murine model of allergic asthma.
Topics: Adrenal Cortex Hormones; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Count; Chemokine CCL17; Chemokines, CC; Dexamethasone; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Receptors, CCR4; Receptors, Chemokine; Receptors, CXCR3; Reverse Transcriptase Polymerase Chain Reaction; RNA | 2005 |
Evaluation of the relationship between cockroach sensitivity and house-dust-mite sensitivity in Turkish asthmatic patients.
Topics: Adult; Allergens; Animals; Antigens, Dermatophagoides; Asthma; Bronchial Provocation Tests; Cockroaches; Dermatophagoides pteronyssinus; Eosinophils; Female; Humans; Immunoglobulin E; Leukocyte Count; Male; Methacholine Chloride; Middle Aged; Pollen; Rural Health; Severity of Illness Index; Skin Tests; Turkey; Urban Health | 2005 |
The prevalence of reversible airflow obstruction and/or methacholine hyperreactivity in random adult asthma patients identified by administrative data.
Topics: Adult; Airway Obstruction; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Female; Humans; Male; Methacholine Chloride; Middle Aged; Prevalence | 2005 |
Bronchial responsiveness and serum eosinophil cationic protein levels in preschool children with recurrent wheezing.
Topics: Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Child; Child, Preschool; Eosinophil Cationic Protein; Female; Humans; Male; Methacholine Chloride; Recurrence; Respiratory Sounds | 2005 |
Socioeconomic risk factors for asthma in Chilean young adults.
Topics: Adult; Age Factors; Asthma; Chile; Female; Humans; Male; Methacholine Chloride; Prevalence; Respiratory Sounds; Risk Factors; Rural Health; Social Class; Socioeconomic Factors; Surveys and Questionnaires | 2005 |
[Bronchial exudate of serum proteins during asthma attack].
Topics: Acute Disease; Adolescent; Adult; alpha-Macroglobulins; Asthma; Blood Cell Count; Blood Proteins; Bronchi; Bronchial Provocation Tests; Capillary Permeability; Eosinophils; Exudates and Transudates; Female; Forced Expiratory Volume; Humans; Macrophages; Male; Methacholine Chloride; Middle Aged; Nephelometry and Turbidimetry; Neutrophils; Serum Albumin; Sputum | 2005 |
Acute inhibition of inducible nitric oxide synthase but not its absence suppresses asthma-like responses.
Topics: Animals; Antigens; Antigens, Ly; Antigens, Surface; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; CD4 Antigens; CD8 Antigens; Enzyme Inhibitors; Eosinophils; Flow Cytometry; Guanidines; Lectins, C-Type; Leukocyte Common Antigens; Leukocyte Count; Lung; Lymphocyte Count; Lymphocytes; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; NK Cell Lectin-Like Receptor Subfamily B; Ovalbumin; Proteins | 2005 |
Low prevalence of asthma in westernizing countries-myth or reality? Prevalence of asthma in Estonia--a report from the "FinEsS" study.
Topics: Adolescent; Adult; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Estonia; Humans; Interviews as Topic; Methacholine Chloride; Middle Aged; Prevalence; Skin Tests; Surveys and Questionnaires | 2005 |
Relation between bronchial responsiveness to inhaled leukotriene D4 and markers of leukotriene biosynthesis.
Topics: Adult; Asthma; Biomarkers; Bronchi; Bronchoconstrictor Agents; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Ionophores; Leukotriene D4; Leukotrienes; Male; Methacholine Chloride | 2005 |
Is forced oscillation technique useful in the diagnosis of occupational asthma?
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; France; Humans; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; ROC Curve; Smoking; Surveys and Questionnaires | 2005 |
Interleukin-13-dependent bronchial hyper-responsiveness following isolated upper-airway allergen challenge in a murine model of allergic rhinitis and asthma.
Topics: Administration, Intranasal; Allergens; Animals; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Granulocytes; Humans; Immunoglobulin E; Immunoglobulin G; Interleukin-13; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Hypersensitivity | 2005 |
Soluble guanylyl cyclase expression is reduced in allergic asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Enzyme Inhibitors; Guanylate Cyclase; Homeostasis; Hypersensitivity; Isoenzymes; Methacholine Chloride; Mice; Ovalbumin; Oxadiazoles; Quinoxalines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Soluble Guanylyl Cyclase | 2006 |
TNF-alpha induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A(2) activation.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytosol; Disease Models, Animal; Enzyme Activation; Histamine; Inflammation; Leukotriene B4; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Phospholipases A; Platelet Activating Factor; Pulmonary Eosinophilia; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2005 |
Follow-up of the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA 2) 1991-2003: methods and characterization of participants.
Topics: Adult; Aged; Air Pollutants, Occupational; Air Pollution; Asthma; Bronchial Provocation Tests; Cohort Studies; Cross-Sectional Studies; Environmental Monitoring; Epidemiological Monitoring; Female; Follow-Up Studies; Humans; Male; Methacholine Chloride; Middle Aged; Population Surveillance; Prospective Studies; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests; Respiratory Hypersensitivity; Risk Factors; Switzerland; Topography, Medical | 2005 |
Immunostimulatory CpG oligonucleotides abrogate allergic susceptibility in a murine model of maternal asthma transmission.
Topics: Adjuvants, Immunologic; Animals; Asthma; CpG Islands; Disease Susceptibility; Dose-Response Relationship, Drug; Female; Infectious Disease Transmission, Vertical; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Oligodeoxyribonucleotides; Pregnancy; Respiratory Hypersensitivity | 2005 |
Prevalence of asthma, allergic rhinoconjunctivitis and allergic sensitization in Mongolia.
Topics: Adolescent; Adult; Allergens; Asthma; Bronchial Provocation Tests; Child; Conjunctivitis, Allergic; Female; Humans; Immunization; Male; Methacholine Chloride; Middle Aged; Mongolia; Prevalence; Rhinitis, Allergic, Perennial; Risk Factors; Skin Tests; Spirometry; Surveys and Questionnaires; Urbanization | 2005 |
Influence of epithelium and isoprenaline incubation on responsiveness of guinea-pig trachea to methacholine.
Topics: Adrenergic beta-Agonists; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bronchodilator Agents; Epithelium; Guinea Pigs; In Vitro Techniques; Isoproterenol; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Trachea | 2006 |
Untreated asthma, final height and sitting height/leg length ratio in Chile.
Topics: Adult; Allergens; Asthma; Body Height; Body Size; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Chile; Cross-Sectional Studies; Female; Humans; Hypersensitivity, Immediate; Longitudinal Studies; Male; Methacholine Chloride; Regression Analysis; Skin Tests | 2006 |
Perception of dyspnea in asthmatics with normal lung function.
Topics: Adolescent; Adult; Age Factors; Aged; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Data Interpretation, Statistical; Dyspnea; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Perception; Sex Factors; Spirometry | 2005 |
Bronchial sensitivity and bronchial reactivity in children with cough variant asthma.
Topics: Administration, Inhalation; Adolescent; Asthma; Bronchial Hyperreactivity; Child; Child, Preschool; Chronic Disease; Cough; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride | 2005 |
A case-control study of bronchial asthma associated with ulcerative colitis: role of airway microvascular permeability.
Topics: Adult; Asthma; Bronchial Provocation Tests; Capillary Permeability; Colitis, Ulcerative; Eosinophils; Female; Humans; Leukocyte Count; Male; Methacholine Chloride; Microcirculation; Nitric Oxide; Respiratory System; Sputum; Vascular Endothelial Growth Factor A | 2005 |
Allergic rhinitis with or without concomitant asthma: difference in perception of dyspnoea and levels of fractional exhaled nitric oxide.
Topics: Adult; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dyspnea; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Pollen; Rhinitis, Allergic, Seasonal; Seasons | 2005 |
Female mice are more susceptible to the development of allergic airway inflammation than male mice.
Topics: Animals; Asthma; B-Lymphocytes; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; CD4 Antigens; Chemokine CCL5; Eosinophils; Female; Immunoglobulin E; Interleukins; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Receptors, Interleukin-2; Sex Factors; T-Lymphocytes; Th2 Cells | 2005 |
Occupational asthma in apprentice adolescent car painters.
Topics: Adolescent; Adult; Asthma; Automobiles; Bronchial Provocation Tests; Humans; Male; Methacholine Chloride; Occupational Diseases; Occupational Exposure; Paint; Peak Expiratory Flow Rate; Prevalence; Respiratory Function Tests; Surveys and Questionnaires; Turkey | 2005 |
Feasibility of shortened methacholine challenge in preschool children.
Topics: Administration, Inhalation; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Child; Child, Preschool; Dose-Response Relationship, Drug; Feasibility Studies; Humans; Methacholine Chloride; Nebulizers and Vaporizers; Oxygen Consumption | 2006 |
Maximal airway response to methacholine in cough-variant asthma: comparison with classic asthma and its relationship to peak expiratory flow variability.
Topics: Age Factors; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Case-Control Studies; Child; Child, Preschool; Cough; Female; Humans; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Probability; Prognosis; Reference Values; Risk Factors; Sensitivity and Specificity; Severity of Illness Index | 2005 |
Difference between dosimeter and tidal breathing methacholine challenge: contributions of dose and deep inspiration bronchoprotection.
Topics: Administration, Inhalation; Adolescent; Adult; Analysis of Variance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Metered Dose Inhalers; Methacholine Chloride; Probability; Respiratory Mechanics; Sensitivity and Specificity; Severity of Illness Index; Spirometry; Tidal Volume | 2005 |
A comparison of 2 methods of continuous aerosol administration during methacholine challenge testing.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Total Lung Capacity | 2006 |
Conflicting methacholine challenge tests.
Topics: Androstadienes; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Child; False Positive Reactions; Fluticasone; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Predictive Value of Tests | 2006 |
Methacholine and adenosine 5'-monophosphate challenges in children with post-infectious bronchiolitis obliterans.
Topics: Adenosine Monophosphate; Analysis of Variance; Asthma; Bronchial Provocation Tests; Bronchiolitis Obliterans; Case-Control Studies; Chi-Square Distribution; Child; Female; Humans; Male; Methacholine Chloride | 2006 |
Anti-tumor necrosis factor-alpha antibody treatment reduces pulmonary inflammation and methacholine hyper-responsiveness in a murine asthma model induced by house dust.
Topics: Allergens; Animals; Antibodies, Monoclonal; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cockroaches; Cytokines; Dust; Endotoxins; Female; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Models, Animal; Tumor Necrosis Factor-alpha | 2006 |
Inter-relationships between airway inflammation, reticular basement membrane thickening and bronchial hyper-reactivity to methacholine in asthma; a systematic bronchoalveolar lavage and airway biopsy analysis.
Topics: Asthma; Basement Membrane; Biopsy; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Case-Control Studies; Humans; Hypersensitivity; Methacholine Chloride; Regression Analysis; Reticulin; Spirometry | 2005 |
The effect of beta2-adrenoceptor haplotypes on bronchial hyper-responsiveness in patients with asthma.
Topics: Adenosine Monophosphate; Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Haplotypes; Humans; Male; Methacholine Chloride; Middle Aged; Polymorphism, Genetic; Receptors, Adrenergic, beta-2; Retrospective Studies | 2006 |
Increase in exhaled nitric oxide (eNO) after work-related isocyanate exposure.
Topics: Asthma; Bronchial Provocation Tests; Exhalation; Germany; Humans; Isocyanates; Methacholine Chloride; Nitric Oxide; Occupational Exposure | 2006 |
Methacholine challenge tests: sample sizes required in crossover trials.
Topics: Algorithms; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Over Studies; Humans; Methacholine Chloride; Practice Guidelines as Topic; Predictive Value of Tests; Sample Size | 2006 |
Early decrease in nasal eosinophil proportion after nasal allergen challenge correlates with baseline bronchial reactivity to methacholine in children sensitized to house dust mites.
Topics: Allergens; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Case-Control Studies; Child; Eosinophils; Female; HLA-DR Antigens; Humans; Immunoglobulin E; Intercellular Adhesion Molecule-1; Leukocyte Count; Male; Methacholine Chloride; Nasal Mucosa; Nasal Provocation Tests; Neutrophils; Pyroglyphidae; Rhinitis, Allergic, Perennial | 2005 |
Involvement of reduced sensitivity to Ca in beta-adrenergic action on airway smooth muscle.
Topics: Adrenergic beta-Agonists; Amides; Animals; Asthma; Bucladesine; Calcium; Calcium Channel Blockers; Colforsin; Cyclic AMP Receptor Protein; Cyclic AMP-Dependent Protein Kinases; Depression, Chemical; Fura-2; Guinea Pigs; Imidazoles; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Isoproterenol; Male; Maleimides; Marine Toxins; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Phosphatase; Oxazoles; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Trachea | 2006 |
Respiratory syncytial virus infection reversed anti-asthma effect of neonatal Bacillus Calmette-Guerin vaccination in BALB/c mice.
Topics: Animals; Animals, Newborn; Asthma; BCG Vaccine; Bronchi; Bronchoalveolar Lavage Fluid; Female; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pregnancy; Respiratory Syncytial Virus Infections | 2006 |
Role of macrophage migration inhibitory factor in ovalbumin-induced airway inflammation in rats.
Topics: Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Enzyme-Linked Immunosorbent Assay; Eosinophils; Interleukin-13; Leukocyte Count; Macrophage Migration-Inhibitory Factors; Male; Methacholine Chloride; Ovalbumin; Rats; Rats, Inbred BN; Respiratory Mucosa | 2006 |
Effect of body mass index on response to methacholine bronchial provocation in healthy and asthmatic adolescents.
Topics: Adolescent; Asthma; Body Mass Index; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Humans; Linear Models; Methacholine Chloride; Vital Capacity | 2006 |
Percentage fall in FVC at the provocative concentration of methacholine causing a 20% fall in FEV1 in symptomatic asthma and clinical remission during adolescence.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Vital Capacity | 2006 |
Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model.
Topics: Adenine; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Adhesion Molecules; Chemokines; Chemotaxis, Leukocyte; Class I Phosphatidylinositol 3-Kinases; Cytokines; Eosinophilia; Female; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Models, Animal; Mucus; Ovalbumin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Quinazolines | 2006 |
Evaluation of bronchial hyperresponsiveness by monitoring of transcutaneous oxygen tension and arterial oxygen saturation during methacholine challenge in asthmatic children.
Topics: Asthma; Blood Gas Monitoring, Transcutaneous; Bronchial Hyperreactivity; Child; Child, Preschool; Female; Humans; Male; Methacholine Chloride; Oxygen | 2006 |
G protein-coupled receptor 154 gene polymorphism is associated with airway hyperresponsiveness to methacholine in a Chinese population.
Topics: Adolescent; Adult; Asian People; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Child; Female; Genetic Predisposition to Disease; Genotype; Humans; Male; Methacholine Chloride; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Receptors, G-Protein-Coupled | 2006 |
Safety of methacholine challenges in a multicenter pediatric asthma study.
Topics: Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Humans; Methacholine Chloride; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Treatment Outcome | 2006 |
Sensitivity of bronchial responsiveness measurements in young infants.
Topics: Asthma; Blood Gas Monitoring, Transcutaneous; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Infant; Male; Methacholine Chloride; Tidal Volume | 2006 |
Oxidant stress modulates murine allergic airway responses.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; F2-Isoprostanes; Female; Lipid Peroxidation; Lung; Macrophages, Alveolar; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Ovalbumin; Oxidative Stress; Specific Pathogen-Free Organisms; Spectrometry, Mass, Electrospray Ionization; Vitamin E; Vitamin E Deficiency | 2006 |
Mechanisms of dyspnoea and its language in patients with asthma.
Topics: Administration, Inhalation; Adult; Aged; Airway Obstruction; Asthma; Bronchial Provocation Tests; Dyspnea; Exercise Test; Female; Humans; Lung Volume Measurements; Male; Methacholine Chloride; Middle Aged; Physical Exertion; Psychophysics; Sick Role; Spirometry | 2006 |
Bronchial hyperresponsiveness is a common feature in patients with chronic urticaria.
Topics: Adult; Aged; Aged, 80 and over; Asthma; Bronchial Hyperreactivity; Case-Control Studies; Chronic Disease; Female; Humans; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests; Urticaria | 2006 |
Inhibition of pan neurotrophin receptor p75 attenuates diesel particulate-induced enhancement of allergic airway responses in C57/B16J mice.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Immunoglobulin E; Interleukin-13; Interleukin-4; Interleukin-5; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Ovalbumin; Receptor, Nerve Growth Factor; Vehicle Emissions | 2006 |
Antigen sensitization modulates alveolar macrophage functions in an asthma model.
Topics: Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Clodronic Acid; Disease Models, Animal; Lung; Macrophages, Alveolar; Male; Methacholine Chloride; Ovalbumin; Rats; Rats, Inbred BN; Tumor Necrosis Factor-alpha | 2006 |
[Methacholine challenge testing in olympic athletes].
Topics: Adrenergic beta-Agonists; Asthma; Humans; Methacholine Chloride; Sports | 2006 |
Determinants of airway responsiveness to adenosine 5'-monophosphate in school-age children with asthma.
Topics: Adenosine Monophosphate; Adolescent; Age Factors; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Cross-Sectional Studies; Exercise Tolerance; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Logistic Models; Male; Methacholine Chloride; Retrospective Studies; Skin Tests | 2006 |
Bronchial responsiveness to methacholine and adenosine 5'-monophosphate in preschool children with bronchopulmonary dysplasia.
Topics: Adenosine Monophosphate; Asthma; Blood Cell Count; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchopulmonary Dysplasia; Child; Child, Preschool; Eosinophils; Female; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Infant, Newborn; Male; Methacholine Chloride; Oximetry; Oxygen; Respiratory Sounds | 2006 |
Reduced airway hyperresponsiveness and tracheal responses during allergic asthma in mice lacking tyrosine kinase inducible T-cell kinase.
Topics: Acetylcholine; Adoptive Transfer; Animals; Asthma; Bronchial Hyperreactivity; Carbachol; CD4-Positive T-Lymphocytes; Cytokines; In Vitro Techniques; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovalbumin; Protein-Tyrosine Kinases; Th2 Cells; Trachea | 2006 |
Airway inflammation in occupational asthma caused by styrene.
Topics: Adult; Air Pollutants, Occupational; Asthma; Bronchial Provocation Tests; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Occupational Diseases; Occupational Exposure; Sputum; Styrene | 2006 |
Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma.
Topics: Acetates; Animals; Anti-Asthmatic Agents; Asthma; Bronchoalveolar Lavage Fluid; Cyclopropanes; Disease Models, Animal; Female; Glucosides; Immunoglobulin E; Interleukin-13; Interleukin-4; Iridoid Glucosides; Iridoids; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Molecular Structure; Mucus; Ovalbumin; Plant Extracts; Pneumonia; Pulmonary Eosinophilia; Quinolines; Sulfides; Veronica | 2006 |
Severe airway hyperresponsiveness in school-aged boys with a high body mass index.
Topics: Age Factors; Asthma; Body Mass Index; Bronchial Hyperreactivity; Child; Comorbidity; Female; Health Surveys; Humans; Hypersensitivity, Immediate; Korea; Male; Methacholine Chloride; Obesity; Risk Factors; Schools; Sex Factors; Surveys and Questionnaires | 2006 |
Histamine type 1 receptor deficiency reduces airway inflammation in a murine asthma model.
Topics: Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Histocytochemistry; Hypersensitivity; Immunoglobulin E; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovalbumin; Receptors, Histamine H1; Specific Pathogen-Free Organisms | 2006 |
Regional pulmonary perfusion, inflation, and ventilation defects in bronchoconstricted patients with asthma.
Topics: Adult; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Female; Humans; Male; Methacholine Chloride; Nitrogen Radioisotopes; Positron-Emission Tomography; Pulmonary Circulation; Pulmonary Ventilation; Ventilation-Perfusion Ratio | 2006 |
Mast cells can promote the development of multiple features of chronic asthma in mice.
Topics: Animals; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Chronic Disease; Disease Models, Animal; Female; Humans; Hyperplasia; Mast Cells; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovalbumin; Proto-Oncogene Proteins c-kit; Receptors, IgG; Respiratory Mucosa | 2006 |
Prevalence and risk factors for work related asthma in young adults.
Topics: Adult; Asthma; Brazil; Bronchial Provocation Tests; Cohort Studies; Cross-Sectional Studies; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride; Occupational Diseases; Odds Ratio; Prevalence; Risk Factors; Skin Tests | 2006 |
Sensitization to aeroallergens and airway hyperresponsiveness at 7 years of age.
Topics: Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Cohort Studies; Humans; Hypersensitivity, Immediate; Inhalation Exposure; Methacholine Chloride; Risk Assessment; Skin Tests | 2006 |
Are risk factors of childhood asthma predicting disease persistence in early adulthood different in the developing world?
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Child; Developing Countries; Eosinophils; Female; Forced Expiratory Volume; Humans; Immunoglobulin E; Leukocyte Count; Male; Methacholine Chloride; Retrospective Studies; Risk Factors; Sex Factors; Skin Tests; Spirometry; Turkey; Vital Capacity | 2006 |
HLA DRB1*15-DPB1*05 haplotype: a susceptible gene marker for isocyanate-induced occupational asthma?
Topics: Adult; Asthma; Biomarkers; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Female; Haplotypes; HLA-DP Antigens; HLA-DP beta-Chains; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Korea; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Occupational Exposure; Skin Tests; Toluene 2,4-Diisocyanate | 2006 |
Airway hyperreactivity in exacerbation of chronic asthma is independent of eosinophilic inflammation.
Topics: Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Chronic Disease; Cytokines; Eosinophils; Female; GATA1 Transcription Factor; Humans; Inflammation; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Ovalbumin | 2006 |
Testing of pulmonary function in a professional cycling team.
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Adult; Asthma; Asthma, Exercise-Induced; Bicycling; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Exercise Test; Follow-Up Studies; Forced Expiratory Flow Rates; Forced Expiratory Volume; France; Humans; Longitudinal Studies; Lung; Male; Maximal Midexpiratory Flow Rate; Methacholine Chloride; Oxygen Consumption; Spirometry | 2006 |
Influence of allergy on the symptoms and treatment of nasal polyposis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Beclomethasone; Bronchial Provocation Tests; Comorbidity; Cross-Sectional Studies; Drug Hypersensitivity; Follow-Up Studies; Forced Expiratory Volume; Humans; Immunoglobulin E; Methacholine Chloride; Nasal Obstruction; Nasal Polyps; Olfaction Disorders; Prednisolone; Prospective Studies; Rhinitis, Allergic, Perennial | 2006 |
A prospective longitudinal study of clinical characteristics, laboratory findings, diagnostic spectrum and outcomes of specific therapy in adult patients with chronic cough in a general respiratory clinic.
Topics: Adolescent; Adult; Aged; Asthma; Bronchial Provocation Tests; Bronchitis, Chronic; Bronchoconstrictor Agents; Chronic Disease; Cough; Female; Gastroesophageal Reflux; Humans; Hydrogen-Ion Concentration; Male; Methacholine Chloride; Middle Aged; Prospective Studies; Pulmonary Disease, Chronic Obstructive; Spirometry; Treatment Outcome | 2006 |
Forced expiratory volume in 1 second percentage improves the classification of severity among children with asthma.
Topics: Albuterol; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Budesonide; Child; Child, Preschool; Cohort Studies; Double-Blind Method; Emergency Service, Hospital; Ethnicity; Female; Follow-Up Studies; Forced Expiratory Volume; Hospitalization; Humans; Male; Methacholine Chloride; Models, Theoretical; Multicenter Studies as Topic; Nedocromil; Randomized Controlled Trials as Topic; Risk; Severity of Illness Index; Spirometry; Treatment Outcome | 2006 |
Intercellular adhesion molecule 1 and tumor necrosis factor alpha in asthma and persistent allergic rhinitis: relationship with disease severity.
Topics: Adolescent; Adult; Aged; Asthma; Biomarkers; Blood Vessels; Bronchial Hyperreactivity; Bronchial Provocation Tests; Comorbidity; Female; Humans; Intercellular Adhesion Molecule-1; Male; Methacholine Chloride; Middle Aged; Nasal Mucosa; Prevalence; Rhinitis, Allergic, Perennial; Severity of Illness Index; Tumor Necrosis Factor-alpha | 2006 |
Is there a link between the qualitative descriptors and the quantitative perception of dyspnea in asthma?
Topics: Administration, Inhalation; Adult; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Dyspnea; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Incidence; Male; Methacholine Chloride; Prognosis; Severity of Illness Index | 2006 |
Magnitude of bronchoprotection of albuterol vs methacholine: relationship to baseline airway caliber.
Topics: Adrenergic beta-Agonists; Albuterol; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Forced Expiratory Volume; Humans; Methacholine Chloride; Muscle, Smooth; Severity of Illness Index | 2006 |
Airway hyper-responsiveness to adenosine 5'-monophosphate in preschool-age children with asthma.
Topics: Adenosine Monophosphate; Asthma; Blood Gas Monitoring, Transcutaneous; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child, Preschool; Eosinophils; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Skin Tests | 2006 |
The structural basis of airways hyperresponsiveness in asthma.
Topics: Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Muscle, Smooth; Residual Volume; Respiratory Muscles; Tomography, X-Ray Computed; Total Lung Capacity; Vital Capacity | 2006 |
Occupational asthma from dried flowers of Carthamus tinctorious (safflower) and Achillea millefolium (yarrow).
Topics: Achillea; Adult; Asthma; Bronchial Provocation Tests; Carthamus tinctorius; Female; Flowers; Forced Expiratory Volume; Humans; Immunoglobulin E; Methacholine Chloride; Occupational Diseases; Plant Extracts; Skin Tests; Urticaria; Water | 2006 |
Inhibition of mucin secretion with MARCKS-related peptide improves airway obstruction in a mouse model of asthma.
Topics: Airway Obstruction; Animals; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucins; Peptide Fragments | 2007 |
Association of excess weight and degree of airway responsiveness in asthmatics and non-asthmatics.
Topics: Adult; Aged; Asthma; Body Mass Index; Bronchial Hyperreactivity; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Obesity; Retrospective Studies | 2006 |
Dyspnea perception and reversibility of methacholine-induced unlimited airway narrowing in asthmatics.
Topics: Adolescent; Adult; Albuterol; Asthma; Bronchi; Bronchoconstriction; Dyspnea; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Perception | 2006 |
Effects of ciclamilast, a new PDE 4 PDE4 inhibitor, on airway hyperresponsiveness, PDE4D expression and airway inflammation in a murine model of asthma.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Allergens; Animals; Anti-Inflammatory Agents; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchitis; Bronchoalveolar Lavage Fluid; Chemokines; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Eosinophilia; Female; Gene Expression; Isoenzymes; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Phosphodiesterase Inhibitors; Pyridines; RNA, Messenger | 2006 |
Immunological determinants of ventilatory changes induced in mice by dermal sensitization and respiratory challenge with toluene diisocyanate.
Topics: Airway Resistance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Immunoglobulins; In Vitro Techniques; Lymphocytes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, SCID; Skin; Toluene 2,4-Diisocyanate | 2007 |
Simulated obesity-related changes in lung volume increases airway responsiveness in lean, nonasthmatic subjects.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Expiratory Reserve Volume; Forced Expiratory Volume; Functional Residual Capacity; Humans; Lung; Lung Volume Measurements; Methacholine Chloride; Models, Biological; Obesity; Physical Stimulation; Pulmonary Ventilation; Random Allocation; Respiratory Function Tests | 2006 |
Inhaled formaldehyde exposure: effect on bronchial response to mite allergen in sensitized asthma patients.
Topics: Adult; Air Pollutants; Animals; Antigens, Dermatophagoides; Arthropod Proteins; Asthma; Bronchi; Cysteine Endopeptidases; Dermatophagoides pteronyssinus; Eosinophil Cationic Protein; Female; Formaldehyde; Humans; Inhalation Exposure; Male; Methacholine Chloride; Sputum | 2006 |
Intrinsic and antigen-induced airway hyperresponsiveness are the result of diverse physiological mechanisms.
Topics: Administration, Inhalation; Animals; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Computer Simulation; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intravenous; Mathematics; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Muscle Contraction; Muscle, Smooth; Phenotype; Respiratory Hypersensitivity | 2007 |
Role of intercellular adhesion molecule-1 in a murine model of toluene diisocyanate-induced asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Chemokine CXCL2; Chemokines; Immunoglobulin E; Immunoglobulin G; Immunohistochemistry; Intercellular Adhesion Molecule-1; Interferon-gamma; Interleukin-4; Interleukin-5; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Occupational Diseases; Time Factors; Toluene 2,4-Diisocyanate; Tumor Necrosis Factor-alpha | 2006 |
High vascular endothelial growth factor levels in NZW mice do not correlate with collagen deposition in allergic asthma.
Topics: Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Collagen; Eosinophil Peroxidase; Eosinophilia; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ovalbumin; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A | 2007 |
Significant linkage to airway responsiveness on chromosome 12q24 in families of children with asthma in Costa Rica.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Bronchoconstrictor Agents; Child; Chromosome Mapping; Chromosomes, Human, Pair 12; Costa Rica; Family Health; Female; Genetic Linkage; Genome, Human; Humans; Lod Score; Male; Methacholine Chloride; Microsatellite Repeats; Middle Aged; Respiratory System | 2007 |
Peak inspiratory flow rate after methacholine challenge in asthmatic patients and its impact on the effect of formoterol via different inhalers.
Topics: Administration, Inhalation; Adolescent; Adult; Aged; Aged, 80 and over; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Child; Ethanolamines; Female; Forced Expiratory Volume; Formoterol Fumarate; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers; Peak Expiratory Flow Rate | 2006 |
Dynamic hyperinflation during bronchoconstriction in asthma: implications for symptom perception.
Topics: Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Dose-Response Relationship, Drug; Dyspnea; Female; Humans; Inhalation; Lung; Lung Compliance; Lung Volume Measurements; Male; Methacholine Chloride; Plethysmography; Spirometry; Statistics as Topic; Work of Breathing | 2006 |
Deep inspiration-induced changes in lung volume decrease with severity of asthma.
Topics: Adolescent; Adult; Aged; Albuterol; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Drug Administration Schedule; Female; Forced Expiratory Volume; Humans; Inhalation; Male; Methacholine Chloride; Middle Aged; Severity of Illness Index; Vital Capacity | 2007 |
Effect of aging on the relationship between asthma severity and bronchial hyperresponsiveness in children with asthma.
Topics: Adolescent; Adult; Age Factors; Analysis of Variance; Asthma; Blood Gas Monitoring, Transcutaneous; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Oscillometry; Severity of Illness Index | 2006 |
Avoidance therapy in reactive dye-induced occupational asthma: long-term follow-up.
Topics: Asthma; Coloring Agents; Follow-Up Studies; Humans; Immunoglobulin E; Korea; Methacholine Chloride; Occupational Diseases; Prognosis; Risk Reduction Behavior; Treatment Outcome | 2006 |
Mouse genetic model for antigen-induced airway manifestations of asthma.
Topics: Animals; Antigens; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Disease Models, Animal; Immunoglobulin E; Male; Methacholine Chloride; Mice; Mice, Congenic; Mice, Inbred BALB C; Mice, Inbred Strains; Ovalbumin; Respiratory System; Species Specificity | 2007 |
Family relational factors in pediatric depression and asthma: pathways of effect.
Topics: Adolescent; Anxiety; Asthma; Bronchoconstrictor Agents; Child; Depression; Expressed Emotion; Family; Family Relations; Female; Humans; Male; Methacholine Chloride; Severity of Illness Index; Social Environment; Surveys and Questionnaires | 2006 |
Features of severe asthma in school-age children: Atopy and increased exhaled nitric oxide.
Topics: Adolescent; Allergens; Asthma; Biomarkers; Bronchial Provocation Tests; Child; Cohort Studies; Diagnosis, Differential; Exhalation; Female; Humans; Hypersensitivity, Immediate; Immunization; Male; Methacholine Chloride; Nitric Oxide; Spirometry | 2006 |
Increased leukotriene E4 in the exhaled breath condensate of children with mild asthma.
Topics: Adolescent; Asthma; Biomarkers; Breath Tests; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Female; Forced Expiratory Volume; Humans; Leukotriene E4; Male; Methacholine Chloride; Reference Values; Statistics as Topic | 2006 |
Multiple measures of magnesium status are comparable in mild asthma and control subjects.
Topics: Adult; Asthma; Body Mass Index; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Diet; Erythrocytes; Female; Humans; Infusions, Intravenous; Ions; Lung; Magnesium; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests; Severity of Illness Index | 2006 |
[Alteration of bronchomotor tone after deep inhalation. Mechanisms and pediatric data].
Topics: Asthma; Asthma, Exercise-Induced; Bronchial Hyperreactivity; Child; Exercise; Humans; Inflammation; Methacholine Chloride; Respiratory Function Tests; Respiratory Therapy | 2007 |
Oral treatment with live Lactobacillus reuteri inhibits the allergic airway response in mice.
Topics: Administration, Oral; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; DNA, Bacterial; Eosinophils; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Limosilactobacillus reuteri; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Probiotics; Toll-Like Receptor 9; Tryptophan | 2007 |
Response to mannitol in asymptomatic subjects with airway hyper-responsiveness to methacholine.
Topics: Adult; Asthma; Breath Tests; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Diuretics, Osmotic; Dose-Response Relationship, Drug; Eosinophilia; Female; Forced Expiratory Volume; Humans; Male; Mannitol; Methacholine Chloride; Middle Aged; Nitric Oxide; Sensitivity and Specificity; Smoking | 2007 |
Validated safety predictions of airway responses to house dust mite in asthma.
Topics: Adult; Animals; Antigens, Dermatophagoides; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Clinical Trials as Topic; Dermatophagoides pteronyssinus; Dose-Response Relationship, Immunologic; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Regression Analysis; Retrospective Studies; Safety; Skin Tests | 2007 |
Association of airway hyperresponsiveness with reduced quality of life in patients with moderate to severe asthma.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Forced Expiratory Volume; Humans; Methacholine Chloride; Quality of Life; Spirometry | 2007 |
The i.v. infusion of mannitol decreases airway responsiveness to methacholine in asthma.
Topics: Airway Resistance; Asthma; Bronchoconstrictor Agents; Diuretics; Humans; Infusions, Intravenous; Male; Mannitol; Methacholine Chloride; Middle Aged; Osmotic Pressure; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests; Respiratory Mechanics | 2007 |
Enhanced airway reactivity and inflammation in A2A adenosine receptor-deficient allergic mice.
Topics: Ambrosia; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cyclic AMP; Disease Models, Animal; I-kappa B Proteins; Leukocytes; Lipid Peroxidation; Male; Methacholine Chloride; Mice; Mice, Inbred Strains; Mice, Knockout; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; Phosphorylation; Plethysmography, Whole Body; Pneumonia; Reactive Nitrogen Species; Receptor, Adenosine A2A; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor RelA; Tyrosine | 2007 |
Comparison of deltaFVC between patients with allergic rhinitis with airway hypersensitivity and patients with mild asthma.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Female; Humans; Male; Methacholine Chloride; Rhinitis; Vital Capacity | 2007 |
Diagnostic classification of persistent rhinitis and its relationship to exhaled nitric oxide and asthma: a clinical study of a consecutive series of patients.
Topics: Adolescent; Adult; Aged; Asthma; Breath Tests; Bronchial Provocation Tests; Child; Chronic Disease; Confidence Intervals; Cross-Sectional Studies; Female; Humans; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Pneumonia; Prevalence; Rhinitis; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Risk Factors; Severity of Illness Index; Sinusitis | 2007 |
Catalase overexpression fails to attenuate allergic airways disease in the mouse.
Topics: Animals; Asthma; Bronchoconstrictor Agents; Catalase; Gene Expression Regulation; Hydrogen Peroxide; Inflammation; Inflammation Mediators; Lung; Methacholine Chloride; Mice; Mice, Transgenic; Ovalbumin; Oxidative Stress; Species Specificity | 2007 |
The characteristics of different diagnostic tests in adult mild asthmatic patients: comparison with patients with asthma-like symptoms by gastro-oesophageal reflux.
Topics: Adult; Asthma; Biomarkers; Bronchial Provocation Tests; Bronchoconstrictor Agents; Diagnosis, Differential; Eosinophil Cationic Protein; Eosinophils; Epidemiologic Methods; Female; Forced Expiratory Volume; Gastroesophageal Reflux; Humans; Leukocyte Count; Male; Methacholine Chloride; Middle Aged; Spirometry; Sputum; Vital Capacity | 2007 |
Perception of dyspnea in mild smoking asthmatics.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Dyspnea; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Perception; Smoking; Vital Capacity | 2007 |
Eosinophil cationic protein (ECP) polymorphisms and association with asthma, s-ECP levels and related phenotypes.
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Eosinophil Cationic Protein; Female; Forced Expiratory Flow Rates; Genotype; Humans; Immunoglobulin E; Male; Methacholine Chloride; Netherlands; Norway; Phenotype; Polymorphism, Single Nucleotide; Skin Tests | 2007 |
Cessation of dexamethasone exacerbates airway responses to methacholine in asthmatic mice.
Topics: Administration, Oral; Airway Resistance; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Dexamethasone; Disease Models, Animal; Drug Administration Schedule; Eosinophils; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; Pulmonary Eosinophilia; Recurrence | 2007 |
[Bronchial hyperresponsiveness to methacholine assessed by means of tracheal auscultation of healthy children aged under 4 years].
Topics: Asthma; Auscultation; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child, Preschool; Disease Susceptibility; Female; Humans; Infant; Male; Methacholine Chloride; Oxygen; Reference Values; Respiratory Sounds; Tidal Volume; Trachea | 2007 |
Short-term variability of airway caliber-a marker of asthma?
Topics: Adolescent; Adult; Aged; Airway Resistance; Asthma; Australia; Bronchial Hyperreactivity; Bronchial Provocation Tests; Case-Control Studies; Child; Circadian Rhythm; Cohort Studies; Equipment Design; Histamine; Humans; Methacholine Chloride; Middle Aged; Oscillometry; Peak Expiratory Flow Rate; Reproducibility of Results; Respiratory System; Severity of Illness Index; Supine Position; Time Factors | 2007 |
Methacholine responsiveness in mice from 2 to 8 wk of age.
Topics: Aging; Animals; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Infusions, Intravenous; Lung; Lung Volume Measurements; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pregnancy; Respiratory Mechanics | 2007 |
Anthocyanins inhibit airway inflammation and hyperresponsiveness in a murine asthma model.
Topics: Animals; Anthocyanins; Anti-Asthmatic Agents; Antioxidants; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Count; Cyclooxygenase 2; Immunohistochemistry; Interleukins; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Oxidative Stress; RNA, Messenger; Tumor Necrosis Factor-alpha | 2007 |
The use of oscillometry as a measure of airway responsiveness in asthmatic children after histamine and methacholine bronchoprovocation with dosimeter-MedicAid and DeVilbiss nebulizers.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Female; Histamine; Humans; Male; Methacholine Chloride; Nebulizers and Vaporizers; Oscillometry; Spirometry | 2007 |
Safety and tolerability of three consecutive bronchoscopies after allergen challenge in volunteers with mild asthma.
Topics: Adult; Allergens; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchoscopy; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged | 2007 |
Persistent airway inflammation and bronchial hyperresponsiveness in patients with totally controlled asthma.
Topics: Adult; Aged; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchitis; Bronchoconstrictor Agents; Case-Control Studies; Eosinophil Cationic Protein; Female; Humans; Interleukin-5; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Prospective Studies; Sputum | 2008 |
Bronchial responsiveness to methacholine and adenosine 5'-monophosphate in young children with asthma: their relationship with blood eosinophils and serum eosinophil cationic protein.
Topics: Adenosine Monophosphate; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Child; Child, Preschool; Eosinophil Cationic Protein; Eosinophils; Female; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride | 2007 |
Immunomodulatory effects of oak dust exposure in a murine model of allergic asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Chemokine CCL3; Chemokine CCL4; Chemokines, CC; Disease Models, Animal; Dust; Female; Inhalation Exposure; Interleukin-13; Leukocytes; Lung; Macrophage Inflammatory Proteins; Macrophages; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Ovalbumin; Quercus; RNA, Messenger; Tumor Necrosis Factor-alpha; Wood | 2007 |
Cysteinyl-leukotriene levels in sputum differentiate asthma from rhinitis patients with or without bronchial hyperresponsiveness.
Topics: Adult; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cysteine; Diagnosis, Differential; Eosinophil Cationic Protein; Female; Forced Expiratory Volume; Humans; Hyaluronic Acid; Leukotrienes; Male; Methacholine Chloride; Middle Aged; Reproducibility of Results; Rhinitis, Allergic, Seasonal; Skin Tests; Sputum | 2007 |
Wheeze detection as a measure of bronchial challenge in young children with cough-variant asthma and with classic asthma.
Topics: Asthma; Auscultation; Blood Gas Analysis; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child, Preschool; Female; Humans; Male; Methacholine Chloride; Reproducibility of Results; Respiratory Sounds; Retrospective Studies; Sensitivity and Specificity | 2007 |
[Comparison of sensitivity and specifity of two bronchial provocation tests with methacholine and hypertonic saline in bronchial hyperreactivity evaluation in asthmatics].
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Reproducibility of Results; Saline Solution, Hypertonic; Sensitivity and Specificity; Spirometry | 2007 |
Lower respiratory tract complications during nasal provocation: nonspecific stimulant or specific allergen?
Topics: Asthma; Bronchoconstrictor Agents; Female; Humans; Lung; Male; Methacholine Chloride; Nasal Provocation Tests; Olea; Plant Extracts; Respiratory Function Tests; Rhinitis, Allergic, Seasonal; Skin Tests | 2007 |
Impulse oscillometry for estimation of airway obstruction and bronchodilation in adults with mild obstructive asthma.
Topics: Adult; Airway Obstruction; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Humans; Male; Methacholine Chloride; Middle Aged; Oscillometry; Respiratory Function Tests; Sensitivity and Specificity | 2007 |
Analysis of longitudinal changes in the psychological status of patients with asthma.
Topics: Anxiety; Asthma; Bronchoconstrictor Agents; Depressive Disorder; Female; Health Status; Humans; Longitudinal Studies; Male; Methacholine Chloride; Middle Aged; Quality of Life; Respiratory Function Tests; Time Factors; Treatment Outcome | 2007 |
Severity of obstructive airways disease by age 2 years predicts asthma at 10 years of age.
Topics: Age Factors; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Case-Control Studies; Child; Cohort Studies; Female; Follow-Up Studies; Humans; Infant; Lung Diseases, Obstructive; Male; Methacholine Chloride; Prognosis; Risk Factors; Severity of Illness Index | 2008 |
Relationships of methacholine and AMP responsiveness with peak expiratory flow variability in children with asthma.
Topics: Adenosine Monophosphate; Adolescent; Asthma; Bronchial Provocation Tests; Child; Female; Follow-Up Studies; Humans; Male; Methacholine Chloride; Muscarinic Agonists; Peak Expiratory Flow Rate; Reproducibility of Results | 2007 |
Exposure to substances in the workplace and new-onset asthma: an international prospective population-based study (ECRHS-II).
Topics: Adult; Asthma; Bronchoconstrictor Agents; Female; Humans; Male; Methacholine Chloride; Occupational Exposure; Occupations; Population Surveillance; Risk Factors; Smoking | 2007 |
Peripheral nitric oxide is increased in rhinitic patients with asthma compared to bronchial hyperresponsiveness.
Topics: Adolescent; Adult; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Case-Control Studies; Female; Humans; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Rhinitis, Allergic, Seasonal; Seasons | 2007 |
Changes in beta 2-adrenoceptor and other signaling proteins produced by chronic administration of 'beta-blockers' in a murine asthma model.
Topics: Adrenergic beta-Antagonists; Airway Resistance; Animals; Asthma; Blotting, Western; Bronchial Provocation Tests; Drug Administration Schedule; Fluorescent Antibody Technique; Intracellular Signaling Peptides and Proteins; Male; Methacholine Chloride; Metoprolol; Mice; Mice, Inbred BALB C; Nadolol; Ovalbumin; Propanolamines; Receptors, Adrenergic, beta-2 | 2008 |
Bronchial responsiveness in bakery workers: relation to airway symptoms, IgE sensitization, nasal indices of inflammation, flour dust exposure and smoking.
Topics: Adolescent; Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Sectional Studies; Dust; Eosinophils; Flour; Food-Processing Industry; Forced Expiratory Volume; Humans; Immunoglobulin E; Interviews as Topic; Methacholine Chloride; Middle Aged; Nasal Lavage Fluid; Norway; Occupational Diseases; Rhinitis; Risk Factors; Smoking; Surveys and Questionnaires; Time Factors | 2007 |
Methacholine challenge in pre-school children--which outcome measure?
Topics: Airway Resistance; Asthma; Auscultation; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Child, Preschool; Cough; Female; Humans; Male; Methacholine Chloride; Oximetry; Oxygen; Predictive Value of Tests; Respiratory Sounds | 2007 |
Methacholine and adenosine 5'-monophosphate challenges in preschool children with cough-variant and classic asthma.
Topics: Adenosine Monophosphate; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Child, Preschool; Cough; Diagnosis, Differential; Female; Humans; Male; Methacholine Chloride; Prospective Studies | 2007 |
Effects of Ecklonia cava ethanolic extracts on airway hyperresponsiveness and inflammation in a murine asthma model: role of suppressor of cytokine signaling.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Eosinophil Peroxidase; Ethanol; Female; Immunoglobulin E; Matrix Metalloproteinase 3; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phaeophyceae; Phytotherapy; Plant Extracts; Solvents; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins | 2008 |
Suppression of the asthmatic phenotype by ultraviolet B-induced, antigen-specific regulatory cells.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Immunity, Cellular; Immunization; Immunoglobulin E; Lymph Nodes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phenotype; Rats; Rats, Sprague-Dawley; Ultraviolet Rays; Ultraviolet Therapy | 2007 |
Asthma definitions, relative validity and impact on known risk factors in young Brazilians.
Topics: Adult; Asthma; Brazil; Bronchial Hyperreactivity; Cohort Studies; Cross-Sectional Studies; Dyspnea; Female; Forced Expiratory Volume; Health Surveys; Humans; Male; Methacholine Chloride; Prevalence; Respiratory Sounds; Risk Factors; Severity of Illness Index; Skin Tests; Surveys and Questionnaires | 2007 |
Occupational Medicine Forum.
Topics: Asthma; Humans; Methacholine Chloride; Occupational Diseases; Parasympathomimetics; Respiratory Function Tests; Syndrome | 2007 |
Methacholine-induced pulmonary gas trapping in a mouse model of allergic asthma: effect of inhaled budesonide and ciglitazone.
Topics: Administration, Inhalation; Airway Obstruction; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchodilator Agents; Budesonide; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophils; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; PPAR gamma; Thiazolidinediones | 2008 |
Methacholine-induced asthma symptoms correlate with impulse oscillometry but not spirometry.
Topics: Adolescent; Adult; Airway Resistance; Asthma; Bronchoconstrictor Agents; Female; Humans; Linear Models; Male; Methacholine Chloride; Middle Aged; Oscillometry; Spirometry; Treatment Outcome | 2008 |
Heightened bronchial hyperresponsiveness in the absence of heightened atopy in children with current wheezing and low income status.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Chile; Female; Humans; Hypersensitivity, Immediate; Income; Male; Methacholine Chloride; Prevalence; Respiratory Sounds; Risk Factors; Skin Tests; Socioeconomic Factors; Spirometry | 2008 |
Bronchial hyperresponsiveness in skiers: field test versus methacholine provocation?
Topics: Adult; Asthma; Asthma, Exercise-Induced; Bronchial Hyperreactivity; Exhalation; Female; Humans; Male; Methacholine Chloride; Norway; Skiing | 2007 |
Dietary supplementation with specific oligosaccharide mixtures decreases parameters of allergic asthma in mice.
Topics: Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Count; Dietary Carbohydrates; Dietary Supplements; Fructans; Galactans; Immunization; Immunoglobulin E; Immunologic Factors; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Oligosaccharides; Ovalbumin; Pectins; Respiratory Hypersensitivity | 2007 |
Diagnostic potential in state space parameters of lung sounds.
Topics: Adolescent; Adult; Asthma; Auscultation; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Female; Forced Expiratory Volume; Heart Sounds; Humans; Male; Methacholine Chloride; Respiratory Sounds; Signal Processing, Computer-Assisted; Young Adult | 2008 |
Airways are more reactive to histamine than to methacholine in patients with mild airway hyperresponsiveness, regardless of atopy.
Topics: Adult; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Eosinophils; Female; Histamine; Humans; Immunoglobulin E; Male; Methacholine Chloride; Severity of Illness Index; Skin Tests | 2007 |
Adrenergic responsiveness: FEV1 and symptom differences in Whites and African Americans with mild asthma.
Topics: Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Black or African American; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Nebulizers and Vaporizers; White People | 2007 |
Heterogeneity of bronchoconstriction does not distinguish mild asthmatic subjects from healthy controls when supine.
Topics: Adolescent; Adult; Airway Resistance; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Case-Control Studies; Female; Forced Expiratory Volume; Humans; Inhalation; Male; Methacholine Chloride; Respiratory Function Tests; Severity of Illness Index; Spirometry; Supine Position; Tomography, X-Ray Computed | 2008 |
Paternal asthma, mold exposure, and increased airway responsiveness among children with asthma in Costa Rica.
Topics: Adolescent; Asthma; Child; Costa Rica; Cross-Sectional Studies; Family Health; Female; Fungi; Humans; Inhalation Exposure; Male; Methacholine Chloride; Multivariate Analysis; Respiratory Hypersensitivity | 2008 |
Effects of allergen on airway narrowing dynamics as assessed by lung-slice technique.
Topics: Airway Resistance; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Disease Models, Animal; Image Processing, Computer-Assisted; Methacholine Chloride; Mice; Mice, Inbred BALB C; Microscopy, Video; Muscle, Smooth; Ovalbumin | 2008 |
Effects of L-arginine and phosphodiesterase-5 inhibitor, sildenafil, on inflammation and airway responsiveness of sensitized BP2 mice.
Topics: Animals; Arginine; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cyclic GMP; Eosinophilia; Eosinophils; Lung; Male; Methacholine Chloride; Mice; Nitric Oxide; Ovalbumin; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Plethysmography, Whole Body; Purines; Sildenafil Citrate; Sulfones | 2007 |
Allergic rhinitis with hyper-responsiveness differ from asthma in degree of peripheral obstruction during metacholine challenge test.
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Case-Control Studies; Female; Humans; Linear Models; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests; Rhinitis, Allergic, Seasonal; Skin Tests; Statistics, Nonparametric | 2008 |
Impact of lung remodelling on respiratory mechanics in a model of severe allergic inflammation.
Topics: Animals; Asthma; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperplasia; Hypertrophy; Methacholine Chloride; Mice; Mice, Inbred BALB C; Microscopy, Electron; Muscarinic Agonists; Muscle, Smooth; Ovalbumin; Pulmonary Alveoli; Pulmonary Eosinophilia; Respiratory Hypersensitivity; Respiratory Mechanics | 2008 |
Glutathione S-transferase genotype increases risk of progression from bronchial hyperresponsiveness to asthma in adults.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cohort Studies; Disease Progression; Female; Genotype; Glutathione Transferase; Humans; Male; Methacholine Chloride; Polymorphism, Single Nucleotide; Prospective Studies; Risk Factors | 2008 |
Ovalbumin-sensitized mice are good models for airway hyperresponsiveness but not acute physiological responses to allergen inhalation.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Female; Humans; Immunoglobulin E; Immunoglobulin G; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Time Factors | 2008 |
A comparative study of the action of various sympathomimetic amine aerosols in counteracting the dyspnea and bronchospasm induced by histamine and by acetyl-beta-methylcholine.
Topics: Adrenal Glands; Aerosols; Asthma; Bronchial Spasm; Choline; Dyspnea; Histamine; Histamine Agents; Methacholine Chloride; Sympathomimetics; Tissue Extracts | 1949 |
Prevalence of work-related symptoms and serum-specific antibodies to wheat flour in exposed workers in the bakery industry.
Topics: Adult; Asthma; Bread; Bronchial Provocation Tests; Bronchoconstrictor Agents; Electrophoresis, Polyacrylamide Gel; Female; Flour; Humans; Immunoblotting; Immunoglobulin E; Immunoglobulin G; Industry; Korea; Male; Methacholine Chloride; Occupational Diseases; Occupational Exposure; Prevalence; Respiratory Hypersensitivity; Secale; Skin Tests; Triticum | 2008 |
Factor analysis in the Genetics of Asthma International Network family study identifies five major quantitative asthma phenotypes.
Topics: Adolescent; Adult; Allergens; Asthma; Bronchoconstrictor Agents; Child; Factor Analysis, Statistical; Female; Forced Expiratory Volume; Humans; Hypersensitivity; Immunoglobulin E; Male; Methacholine Chloride; Phenotype; Respiratory Function Tests; Rhinitis; Severity of Illness Index; Skin Tests; Vital Capacity | 2008 |
Shortening of the induction period of allergic asthma in cynomolgus monkeys by Ascaris suum and house dust mite.
Topics: Administration, Inhalation; Administration, Oral; Airway Resistance; Allergens; Androstadienes; Animals; Anti-Asthmatic Agents; Antigens, Dermatophagoides; Ascaris suum; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cells, Cultured; Disease Models, Animal; Fluticasone; Helminth Proteins; Immunoglobulin E; Injections, Intramuscular; Injections, Intraperitoneal; Interleukin-4; Interleukin-5; Intradermal Tests; Leukocytes, Mononuclear; Macaca fascicularis; Male; Methacholine Chloride; Prednisolone; Receptors, CCR4; T-Lymphocytes, Helper-Inducer; Time Factors | 2008 |
Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokines.
Topics: Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Computational Biology; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Humans; Inflammation; Male; Methacholine Chloride; Phenotype; Severity of Illness Index | 2008 |
Ym1 and Ym2 expression in a mouse model exposed to diesel exhaust particles.
Topics: Air Pollutants; Animals; Asthma; beta-N-Acetylhexosaminidases; Bronchoalveolar Lavage Fluid; Chitinases; Disease Models, Animal; Environmental Monitoring; Female; Gasoline; Gene Expression; Inhalation Exposure; Interleukin-4; Lectins; Methacholine Chloride; Mice; Mice, Inbred BALB C; Particle Size; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Specific Pathogen-Free Organisms; Vehicle Emissions | 2008 |
Blood lead levels and increased bronchial responsiveness.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Cross-Sectional Studies; Female; Humans; Korea; Lead; Male; Methacholine Chloride; Middle Aged | 2008 |
Adenosine 5'-monophosphate in asthma: gas exchange and sputum cellular responses.
Topics: Adenosine Monophosphate; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cohort Studies; Female; Forced Expiratory Volume; Humans; Hypoxia; Male; Methacholine Chloride; Pulmonary Gas Exchange; Sputum | 2008 |
Acute effects of Asian dust events on respiratory symptoms and peak expiratory flow in children with mild asthma.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Child; Dust; Female; Humans; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Respiration Disorders | 2008 |
Temporal variability in the responses of individual canine airways to methacholine.
Topics: Animals; Asthma; Bronchodilator Agents; Data Interpretation, Statistical; Dogs; Image Processing, Computer-Assisted; Infusions, Intravenous; Methacholine Chloride; Regression Analysis; Respiratory System; Time Factors; Tomography, X-Ray Computed | 2008 |
Establishing the phenotype in novel acute and chronic murine models of allergic asthma.
Topics: Acute Disease; Administration, Inhalation; Allergens; Animals; Antibodies; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cell Count; Chronic Disease; Disease Models, Animal; Hypersensitivity; Immunoglobulin E; Immunoglobulin G; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phenotype; Plethysmography, Whole Body; Pneumonia; Respiratory Function Tests | 2008 |
Sam So Eum, a herb extract, as the remedy for allergen-induced asthma in mice.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Antibodies; Asthma; Body Weight; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Female; Immunoglobulins; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Plant Extracts; Plethysmography | 2008 |
Effects of combined BCG and DHEA treatment in preventing the development of asthma.
Topics: Animals; Asthma; Bronchial Provocation Tests; Dehydroepiandrosterone; Female; Humans; Immunoglobulin E; Injections, Subcutaneous; Interferon-gamma; Interleukin-4; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Models, Animal; Mycobacterium bovis; Ovalbumin; Sex Factors | 2008 |
Frequency of atopy and allergic disorders among adults with Type 1 diabetes mellitus in the southern Marmara region of Turkey.
Topics: Adult; Asthma; Diabetes Mellitus, Type 1; Female; Humans; Hypersensitivity; Hypersensitivity, Immediate; Male; Methacholine Chloride; Respiratory Function Tests; Skin Tests; Surveys and Questionnaires; Turkey | 2008 |
Computational assessment of airway wall stiffness in vivo in allergically inflamed mouse models of asthma.
Topics: Airway Resistance; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Computer Simulation; Disease Models, Animal; Elasticity; Female; Inflammation; Injections, Intravenous; Methacholine Chloride; Mice; Mice, Inbred BALB C; Models, Biological; Ovalbumin; Time Factors | 2008 |
Animal models of airway sensitization.
Topics: Airway Resistance; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cell Count; Cell Proliferation; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunity, Cellular; Immunization; Lung Compliance; Methacholine Chloride; Mice; Ovalbumin; Plethysmography, Whole Body | 2007 |
A case of occupational rhinitis caused by porcine pancreatic extract developing into occupational asthma.
Topics: Adult; Animals; Asthma; Bronchial Provocation Tests; Female; Gastrointestinal Agents; Humans; Immunoglobulin E; Methacholine Chloride; Occupational Diseases; Pancreatic Extracts; Powders; Rhinitis; Skin Tests; Swine | 2008 |
Mepacrine alleviates airway hyperresponsiveness and airway inflammation in a mouse model of asthma.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cysteine; Cytokines; Disease Models, Animal; Eosinophils; Immunoglobulin E; Inflammation; Leukotrienes; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Phospholipases A2, Secretory; Quinacrine | 2008 |
Attenuated methacholine airway response following repeat testing in a murine model of allergic airways disease.
Topics: Animals; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Female; Inflammation; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin | 2008 |
Retention of mild asthmatics in the navy (REMAIN): a low-risk approach to giving mild asthmatics an opportunity for military service.
Topics: Adolescent; Adult; Asthma; Case-Control Studies; Female; Health Status; Health Surveys; Humans; Male; Methacholine Chloride; Military Personnel; Naval Medicine; Occupational Health; Organizational Policy; Prospective Studies; Risk Assessment; Severity of Illness Index; Surveys and Questionnaires; United States | 2008 |
Tolerance and rebound with zafirlukast in patients with persistent asthma.
Topics: Adult; Aged; Asthma; Dinoprostone; Double-Blind Method; Female; Humans; Indoles; Leukotriene Antagonists; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Peak Expiratory Flow Rate; Phenylcarbamates; Placebos; Receptors, Adrenergic, beta-2; Sulfonamides; Tosyl Compounds | 2008 |
Asp-Tyr-Leu-Lys tetrapeptide inhibits airway inflammation in toluene-2,4-diisocyanate-induced asthma mice.
Topics: Actins; Animals; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cattle; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Immunohistochemistry; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucin 5AC; Mucins; Oligopeptides; Proliferating Cell Nuclear Antigen; Statistics, Nonparametric; Toluene 2,4-Diisocyanate; Trachea; Vascular Endothelial Growth Factor A | 2008 |
Occupational asthma without bronchial hyperresponsiveness.
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Occupational Diseases; Peak Expiratory Flow Rate; Pulmonary Ventilation; Toluene 2,4-Diisocyanate | 1984 |
In vitro responses of human asthmatic airway and pulmonary vascular smooth muscle.
Topics: Allergens; Asthma; Bronchi; Capsaicin; Histamine; Humans; In Vitro Techniques; Leukotriene B4; Methacholine Chloride; Methacholine Compounds; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Poaceae; Pulmonary Artery; Pulmonary Veins; Serotonin | 1984 |
Do amines induce occupational asthma in workers manufacturing polyurethane foams?
Topics: Amines; Asthma; Chemical Industry; Humans; Methacholine Chloride; Methacholine Compounds; Occupational Diseases; Phenylenediamines; Polyurethanes; Toluene 2,4-Diisocyanate | 1984 |
Basenji-greyhound dog model of asthma: pulmonary responses after beta-adrenergic blockade.
Topics: Adrenergic beta-Antagonists; Aerosols; Airway Resistance; Animals; Asthma; Citrates; Citric Acid; Disease Models, Animal; Dogs; Heart Rate; Lung Compliance; Methacholine Chloride; Methacholine Compounds; Respiration | 1981 |
A comparison of late reactions to antigen and exercise.
Topics: Albuterol; Antigens; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Chemotactic Factors; Cromolyn Sodium; Forced Expiratory Volume; Histamine Release; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Interleukin-8; Mast Cells; Methacholine Chloride; Methacholine Compounds; Respiratory Hypersensitivity; Skin Tests; Theophylline | 1984 |
Time course of the bronchoconstriction induced by inhaled histamine and methacholine.
Topics: Adolescent; Adult; Aerosols; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Functional Residual Capacity; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Time Factors | 1983 |
Role of mediators in allergic and nonallergic asthma in dogs with hyperreactive airways.
Topics: Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Chromones; Citrates; Citric Acid; Dogs; Guinea Pigs; Histamine; Hypersensitivity; Lung Compliance; Methacholine Chloride; Methacholine Compounds; Muscle Contraction; Respiratory Tract Diseases; Tissue Extracts | 1983 |
Baker's asthma. Clinical and immunological studies.
Topics: Adult; Asthma; Bronchial Provocation Tests; Flour; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Occupational Diseases; Radioallergosorbent Test; Secale; Skin Tests; Smoking; Triticum | 1983 |
Relationship between types of asthmatic reaction, nonspecific bronchial reactivity, and specific IgE antibodies in patients with red cedar asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Forced Expiratory Volume; Humans; Immunoglobulin E; Lignans; Methacholine Chloride; Methacholine Compounds; Middle Aged; Naphthols; Radioallergosorbent Test; Time Factors | 1983 |
Methods for assessing bronchial reactivity.
Topics: Allergens; Asthma; Bronchi; Bronchial Provocation Tests; Dinoprost; Gases; Histamine; Humans; Methacholine Chloride; Methacholine Compounds; Physical Stimulation; Prostaglandins F; Respiration; Respiratory Function Tests; Respiratory Hypersensitivity | 1983 |
Comparison of the tussive effects of histamine and methacholine in humans.
Topics: Adult; Aged; Asthma; Bronchial Spasm; Chronic Disease; Cough; Female; Histamine; Humans; Male; Metaproterenol; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1983 |
[Diagnosis of the hyperreacting bronchial system].
Topics: Asthma; Bronchial Provocation Tests; Humans; Methacholine Chloride; Methacholine Compounds; Occupational Diseases; Respiratory Hypersensitivity | 1983 |
Decreased sensitivity and response of isolated tracheal muscle to methacholine and histamine without changing the activity of pulmonary muscarinic receptors in the egg albumin-sensitized guinea pig.
Topics: Animals; Asthma; Guinea Pigs; Histamine; Immunization; Lung; Methacholine Chloride; Methacholine Compounds; Muscle, Smooth; Ovalbumin; Receptors, Muscarinic; Trachea | 1983 |
Comparison of airway reactivity induced by histamine, methacholine, and isocapnic hyperventilation in normal and asthmatic subjects.
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Cold Temperature; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Respiration | 1983 |
Bronchial responsiveness to methacholine and effects of respiratory maneuvers.
Topics: Asthma; Bronchi; Bronchial Provocation Tests; Bronchial Spasm; Forced Expiratory Volume; Humans; Maximal Midexpiratory Flow Rate; Methacholine Chloride; Methacholine Compounds; Respiration | 1984 |
Effect of prior bronchoconstriction on the airway response to histamine in normal subjects.
Topics: Adult; Aerosols; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Sodium Chloride; Time Factors | 1984 |
Comparison of responsiveness to methacholine, histamine, and exercise in subgroups of asthmatic children.
Topics: Adolescent; Airway Resistance; Asthma; Bronchial Provocation Tests; Child; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Physical Exertion | 1984 |
Effect of inspiratory flow rate on bronchomotor tone in normal and asthmatic subjects.
Topics: Adult; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Bronchospirometry; Female; Humans; Lidocaine; Lung Volume Measurements; Male; Methacholine Chloride; Methacholine Compounds; Pulmonary Ventilation | 1984 |
Methacholine challenge test.
Topics: Asthma; Bronchial Provocation Tests; Diagnosis, Differential; Dose-Response Relationship, Drug; Humans; Methacholine Chloride; Methacholine Compounds; Spirometry | 1984 |
Airway responses in offspring of dogs with and without airway hyperreactivity.
Topics: Airway Resistance; Animals; Asthma; Bronchi; Citrates; Citric Acid; Dogs; Female; Lung Compliance; Male; Methacholine Chloride; Methacholine Compounds; Phenotype; Respiratory Hypersensitivity | 1984 |
A method for comparing the peak intensity and duration of action of aerosolized bronchodilators using bronchoprovocation with methacholine.
Topics: Adolescent; Adult; Aerosols; Asthma; Bronchi; Bronchial Provocation Tests; Bronchodilator Agents; Female; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Isoetharine; Male; Metaproterenol; Methacholine Chloride; Methacholine Compounds; Time Factors | 1984 |
[Airway response to inhaled methacholine and to exercise in adult asthmatics].
Topics: Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Female; Humans; Lung Volume Measurements; Male; Methacholine Chloride; Methacholine Compounds; Physical Exertion | 1983 |
Methodological aspects of assessment of non-specific bronchial hyperreactivity.
Topics: Adult; Aged; Airway Resistance; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Respiratory Hypersensitivity | 1984 |
Application of a new direct-writing recorder device, the "Astograph," to the evaluation of methacholine-induced bronchoconstriction in asthmatic children.
Topics: Adolescent; Adult; Asthma; Bronchi; Bronchial Provocation Tests; Bronchography; Child; Evaluation Studies as Topic; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Peak Expiratory Flow Rate; Vital Capacity | 1984 |
[Bronchial reactivity assessed by the methacholine test].
Topics: Adult; Asthma; Bronchi; Bronchitis; Dyspnea; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Mucous Membrane | 1984 |
[Study of bronchial hyperreactivity by inhalation of measured aerosol sprays of methacholine].
Topics: Adolescent; Adult; Aged; Asthma; Bronchial Provocation Tests; Child; Humans; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1984 |
Inhalation challenge testing for asthma. Role of bronchial provocation tests in clinical practice.
Topics: Aerosols; Air; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Cold Temperature; Forced Expiratory Volume; Histamine; Humans; Medical History Taking; Methacholine Chloride; Methacholine Compounds; Physical Examination; Water | 1984 |
Leukocyte activation in allergen-induced late-phase asthmatic reactions.
Topics: Adult; Allergens; Asthma; Bronchial Provocation Tests; Chemotaxis, Leukocyte; Female; Forced Expiratory Volume; Humans; Leukocytes; Male; Methacholine Chloride; Methacholine Compounds; Monocytes; Neutrophils; Rosette Formation | 1984 |
Cold air as a bronchial provocation technique. Reproducibility and comparison with histamine and methacholine inhalation.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Cold Temperature; Female; Histamine; Humans; Lung; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1984 |
Response of nasal blood flow to neurohormones as measured by laser-Doppler velocimetry.
Topics: Adolescent; Adult; Asthma; Female; Humans; Imidazoles; Male; Methacholine Chloride; Methacholine Compounds; Microcirculation; Middle Aged; Nasal Mucosa; Nasal Provocation Tests; Oxymetazoline; Phenylephrine; Rheology; Rhinitis, Allergic, Seasonal | 1984 |
The relationship between bronchial hyperresponsiveness to methacholine and airway smooth muscle structure and reactivity.
Topics: Adult; Aged; Asthma; Bronchi; Carbachol; Female; Forced Expiratory Volume; Histamine; Humans; In Vitro Techniques; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Muscle Contraction; Muscle, Smooth; Respiration; Smoking; Vital Capacity | 1984 |
Calcium channel blocking agents in bronchial hyperreactivity.
Topics: Airway Resistance; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Bronchial Spasm; Calcium Channel Blockers; Cold Temperature; Histamine; Humans; Methacholine Chloride; Methacholine Compounds; Nifedipine; Verapamil | 1984 |
Clinical application of inhalation tests in patients with airway allergy.
Topics: Adolescent; Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Respiratory Hypersensitivity; Rhinitis, Allergic, Perennial | 1984 |
Sodium cromoglycate in histamine and methacholine reactivity in asthma.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Cromolyn Sodium; Histamine; Humans; Methacholine Chloride; Methacholine Compounds | 1984 |
Gas exchange responses to bronchodilators following methacholine challenge in dogs.
Topics: Animals; Asthma; Bronchodilator Agents; Carbon Dioxide; Catecholamines; Dogs; Hemodynamics; Lung; Methacholine Chloride; Methacholine Compounds; Oxygen; Oxygen Consumption; Pulmonary Gas Exchange; Ventilation-Perfusion Ratio | 1984 |
[Bronchial provocation tests in children: their practical performance].
Topics: Acetylcholine; Allergens; Asthma; Bronchial Provocation Tests; Carbachol; Child; Dose-Response Relationship, Immunologic; Humans; Methacholine Chloride; Methacholine Compounds; Solvents; Time Factors | 1981 |
Clinical applicability of a methacholine inhalational challenge.
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Child; Female; Humans; Methacholine Chloride; Methacholine Compounds; Middle Aged; Respiratory Function Tests; Respiratory Sounds | 1981 |
Evaluation and expression of bronchial provocation tests.
Topics: Adolescent; Adult; Aged; Antigens; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Histamine; Humans; Methacholine Chloride; Methacholine Compounds; Middle Aged; Reference Standards | 1981 |
Drug-induced changes in airways obstruction reflected by forced expiratory flows and airway resistance measured with an oscillometric method using quiet breathing.
Topics: Adult; Aged; Airway Resistance; Albuterol; Asthma; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Occupational Diseases; Oscillometry; Phenylephrine; Vital Capacity | 1981 |
A new diagnostic test to assess airway reactivity in asthmatics.
Topics: Adolescent; Adult; Aerosols; Asthma; Bronchial Provocation Tests; Child; Female; Humans; Hyperventilation; Lung Volume Measurements; Male; Methacholine Chloride; Methacholine Compounds | 1981 |
Airway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptoms of asthma.
Topics: Adolescent; Adult; Aged; Albuterol; Asthma; Bronchi; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1981 |
Effect of aerosol and oral fenoterol on histamine and methacholine challenge in asthmatic subjects.
Topics: Administration, Oral; Adult; Aerosols; Asthma; Bronchi; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Ethanolamines; Female; Fenoterol; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds | 1981 |
[Bronchial provocation tests by inhalation of non-allergenic agents].
Topics: Aerosols; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Histamine; Humans; Maximal Expiratory Flow-Volume Curves; Methacholine Chloride; Methacholine Compounds | 1982 |
Linkage of high-affinity IgE receptor gene with bronchial hyperreactivity, even in absence of atopy.
Topics: Adult; Alleles; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Chromosome Mapping; Chromosomes, Human, Pair 11; Female; Genes, Immunoglobulin; Genetic Linkage; Heterozygote; Humans; Hypersensitivity; Introns; Male; Methacholine Chloride; Microsatellite Repeats; Middle Aged; Mutation; Phenotype; Polymorphism, Genetic; Receptors, IgE | 1995 |
Maternal asthma and idiopathic preterm labor.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Case-Control Studies; Female; Forced Expiratory Volume; Humans; Hypersensitivity; Medical History Taking; Methacholine Chloride; Obstetric Labor, Premature; Pregnancy; Pregnancy Complications; Spirometry | 1995 |
Occupational IgE-mediated sensitization and asthma caused by clam and shrimp.
Topics: Adult; Animals; Asthma; Bivalvia; Bronchial Provocation Tests; Bronchoconstrictor Agents; Decapoda; Environmental Monitoring; Female; Food Hypersensitivity; Food-Processing Industry; Forced Expiratory Volume; Humans; Immunoglobulin E; Male; Methacholine Chloride; Occupational Diseases; Prevalence; Radioallergosorbent Test; Seafood; Skin Tests; Surveys and Questionnaires | 1995 |
Defect in potentiation of adenylyl cyclase correlates with bronchial hyperreactivity.
Topics: Adenylyl Cyclases; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Calcimycin; Cyclic AMP; Drug Synergism; Female; Humans; Ionophores; Isoproterenol; Leukocytes, Mononuclear; Male; Methacholine Chloride; Phytohemagglutinins; Signal Transduction | 1995 |
IgE-mediated allergic reaction in drug-induced asthma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Candida albicans; Child; Child, Preschool; Drug Hypersensitivity; Dust; Female; Histamine Release; Humans; Immunoglobulin E; Immunoglobulin M; Leukotriene B4; Male; Methacholine Chloride; Middle Aged; Radioallergosorbent Test; Retrospective Studies; Skin Tests | 1993 |
Chemical mediator and cellular reaction in the bronchoalveolar lavage fluid of patients with steroid-dependent intractable asthma (SDIA).
Topics: Adult; Aged; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Female; Glucocorticoids; Histamine Release; Humans; Leukotriene C4; Male; Methacholine Chloride; Middle Aged; Substance-Related Disorders | 1993 |
Neutrophil elastase inhibitor reduces asthmatic responses in allergic sheep.
Topics: Airway Resistance; Animals; Antigens; Asthma; Benzoquinones; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Calcimycin; Glycine; Heterocyclic Compounds; Leukocyte Elastase; Leukocytes; Leukotriene B4; Masoprocol; Methacholine Chloride; Pancreatic Elastase; Polycyclic Compounds; Sheep; Sulfonamides; Thromboxane B2 | 1995 |
Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice.
Topics: Analysis of Variance; Animals; Asthma; Chromosome Mapping; Crosses, Genetic; DNA; Female; Genetic Linkage; Genotype; Humans; Kidney; Lod Score; Lung; Male; Mammals; Methacholine Chloride; Mice; Mice, Inbred A; Mice, Inbred C57BL; Parasympathomimetics; Phenotype; Plethysmography; Polymerase Chain Reaction; Respiratory Function Tests | 1995 |
Relation of the course of bronchial responsiveness from age 9 to age 15 to allergy.
Topics: Adolescent; Aging; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Cohort Studies; Cross-Sectional Studies; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Male; Methacholine Chloride; Sex Factors; Skin Tests; Spirometry | 1995 |
Work-related late asthmatic response induced by latex allergy.
Topics: Adult; Asthma; Bronchial Provocation Tests; Female; Follow-Up Studies; Gloves, Surgical; Humans; Hypersensitivity; Hypersensitivity, Delayed; Immunoglobulin E; Latex; Male; Methacholine Chloride; Occupational Diseases; Peak Expiratory Flow Rate; Respiration; Skin Tests; Time Factors | 1995 |
Peak expiratory flow variation and bronchial hyperresponsiveness in asthmatic children during periods of antigen avoidance and reexposure.
Topics: Adolescent; Allergens; Altitude; Animals; Antigens; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Child; Dust; Female; Humans; Male; Methacholine Chloride; Mites; Peak Expiratory Flow Rate | 1995 |
Standardization of methacholine inhalation challenge by a reservoir method.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Chronic Disease; Cough; Dose-Response Relationship, Drug; Female; Humans; Lung Diseases, Obstructive; Male; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers; Reference Standards; Rhinitis, Allergic, Seasonal | 1994 |
Asthma and bronchial reactivity: a contribution from multivariate analysis.
Topics: Adolescent; Adult; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cluster Analysis; Humans; Immunoglobulin E; Italy; Male; Methacholine Chloride; Military Personnel; Multivariate Analysis; Pollen; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Skin Tests | 1995 |
Comparison of dose-response slopes obtained by simultaneous assessment of changes in FEV1 and transcutaneous oxygen partial pressure during methacholine challenges in asthmatic patients.
Topics: Adult; Asthma; Blood Gas Monitoring, Transcutaneous; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride | 1995 |
The effect of size and age of subject on airway responsiveness in children.
Topics: Adolescent; Aging; Asthma; Body Constitution; Body Height; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Child; Child, Preschool; Cohort Studies; Female; Forced Expiratory Volume; Functional Residual Capacity; Humans; Longitudinal Studies; Male; Methacholine Chloride; Respiratory Sounds; Sex Factors; Spirometry; Total Lung Capacity | 1995 |
[Experimental determination of equivalent percentage changes in measurement parameters of dose-response relations with the inhaled methacholine provocation test].
Topics: Adolescent; Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Humans; Lung Volume Measurements; Male; Methacholine Chloride; Respiratory Hypersensitivity | 1995 |
Effects of diurnal variation and prolonged refractoriness on repeated measurements of airways responsiveness to methacholine.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Case-Control Studies; Circadian Rhythm; Confounding Factors, Epidemiologic; Epidemiologic Methods; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Reproducibility of Results; Retrospective Studies; Time Factors | 1995 |
Age-related changes in bronchial hyperreactivity to methacholine in asthmatic children.
Topics: Adolescent; Age Factors; Aging; Asthma; Blood Gas Monitoring, Transcutaneous; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Child, Preschool; Female; Humans; Male; Matched-Pair Analysis; Methacholine Chloride | 1995 |
Measuring the prevalence of bronchial hyper-responsiveness in children.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Epidemiologic Methods; Female; Humans; Male; Methacholine Chloride; Predictive Value of Tests; Prevalence; Respiratory Sounds; Sensitivity and Specificity; Surveys and Questionnaires; Video Recording | 1995 |
Bronchial asthma caused by two unrelated vegetables.
Topics: Antibodies; Asthma; Bronchial Provocation Tests; Fabaceae; Female; Food Hypersensitivity; Forced Expiratory Volume; Histamine Release; Humans; Immunoglobulin E; Leukocytes; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Plants, Medicinal; Skin Tests; Vegetables | 1993 |
Gas trapping as a predictor of positive methacholine challenge in patients with normal spirometry results.
Topics: Adolescent; Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Female; Gases; Humans; Male; Methacholine Chloride; Middle Aged; Predictive Value of Tests; Respiratory Function Tests; Retrospective Studies; Sensitivity and Specificity; Spirometry | 1995 |
Influence of lung volume on collateral resistance during methacholine-induced bronchospasm.
Topics: Adult; Airway Resistance; Asthma; Bronchial Spasm; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride | 1994 |
Effect of nasal continuous positive airway pressure on methacholine-induced bronchoconstriction.
Topics: Acute Disease; Adult; Aged; Albuterol; Asthma; Combined Modality Therapy; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Middle Aged; Muscle, Smooth; Positive-Pressure Respiration | 1995 |
Circulating interleukin-6 levels in patients with bronchial asthma.
Topics: Adult; Aged; Allergens; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Interleukin-6; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate | 1995 |
Association of Glu 27 beta 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects.
Topics: Adult; Asthma; Base Sequence; Bronchial Hyperreactivity; Genotype; Humans; Methacholine Chloride; Molecular Sequence Data; Polymerase Chain Reaction; Polymorphism, Genetic; Receptors, Adrenergic, beta-2 | 1995 |
Asthmatic symptoms, airway responsiveness and recognition of bronchoconstriction.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Surveys and Questionnaires | 1995 |
Changes in sensitivity to methacholine after inhalation with distilled water: the role of the bronchoconstrictive response.
Topics: Adolescent; Aerosols; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Case-Control Studies; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Reproducibility of Results; Water | 1995 |
The effect of methacholine-induced acute airway narrowing on lung sounds in normal and asthmatic subjects.
Topics: Adult; Asthma; Auscultation; Bronchial Provocation Tests; Bronchoconstriction; Case-Control Studies; Humans; Male; Methacholine Chloride; Pulmonary Ventilation; Reproducibility of Results; Respiratory Sounds; Signal Processing, Computer-Assisted; Spirometry | 1995 |
Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide.
Topics: Adult; Allergens; Asthma; Breath Tests; Bronchial Hyperreactivity; Bronchial Provocation Tests; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Nitric Oxide; Skin Tests; Time Factors | 1995 |
Effects of allergen challenge on eosinophils, eosinophil cationic protein, and granulocyte-macrophage colony-stimulating factor in mild asthma.
Topics: Adult; Allergens; Asthma; Biopsy; Blood Proteins; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoscopy; Eosinophil Granule Proteins; Eosinophils; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunohistochemistry; Inflammation Mediators; Lymphocyte Activation; Male; Methacholine Chloride; Ribonucleases; Skin Tests | 1995 |
Bronchial responsiveness and symptoms in 5-6 year old children: a comparison of a direct and indirect challenge.
Topics: Asthma; Bronchi; Bronchial Provocation Tests; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Methacholine Chloride; Respiratory Sounds; Saline Solution, Hypertonic | 1995 |
Beta 2 adrenergic receptor gene restriction fragment length polymorphism and bronchial asthma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Albuterol; Alleles; Asthma; Bronchi; Bronchial Provocation Tests; Child; Cyclic AMP; Female; Humans; Incidence; Japan; Male; Methacholine Chloride; Middle Aged; Monocytes; Pedigree; Polymorphism, Restriction Fragment Length; Receptors, Adrenergic, beta-2 | 1995 |
The measurement of methacholine responsiveness in 5 year old children: three methods compared.
Topics: Airway Resistance; Asthma; Auscultation; Blood Gas Monitoring, Transcutaneous; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child, Preschool; Feasibility Studies; Female; Humans; Male; Methacholine Chloride; Reproducibility of Results; Respiratory Sounds | 1995 |
Airway response to acid instillation in esophagus in bronchial asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Case-Control Studies; Esophagus; Female; Gastric Acid; Gastroesophageal Reflux; Humans; Male; Methacholine Chloride; Spirometry | 1995 |
Aspecific bronchial hyperreactivity in pulmonary sarcoidosis.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Prednisone; Sarcoidosis, Pulmonary; Smoking | 1994 |
[Bronchial hyperresponsiveness and relaxability in patients with mitral stenosis].
Topics: Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Middle Aged; Mitral Valve Stenosis; Muscle Relaxation | 1994 |
Postnatal maternal smoking increases the prevalence of asthma but not of bronchial hyperresponsiveness or atopy in their children.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Cross-Sectional Studies; Fathers; Female; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride; Mothers; Odds Ratio; Pregnancy; Prenatal Exposure Delayed Effects; Skin Tests; Tobacco Smoke Pollution | 1995 |
Lack of significant bronchial reactivity to inhaled normal saline in subjects with a positive methacholine challenge test.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Retrospective Studies; Sodium Chloride; Spirometry | 1995 |
Inspiratory fall in systolic pressure in normal and asthmatic subjects.
Topics: Adult; Asthma; Blood Pressure; Blood Pressure Monitors; Bronchial Provocation Tests; Cardiac Catheterization; Female; Humans; Lung Volume Measurements; Male; Methacholine Chloride; Middle Aged; Posture; Respiration; Spirometry; Systole | 1995 |
[Current use, methodology and evaluation of nonspecific bronchial provocation tests in our country].
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Follow-Up Studies; Humans; Methacholine Chloride; Spain; Surveys and Questionnaires | 1995 |
Relationship between serum IgE and airway responsiveness in adults with asthma.
Topics: Administration, Inhalation; Adolescent; Adult; Airway Obstruction; Asthma; Bronchial Provocation Tests; Cross-Sectional Studies; Female; Forced Expiratory Volume; Humans; Immunoglobulin E; Male; Methacholine Chloride; Middle Aged; Skin Tests | 1995 |
Prospective study of occupational asthma to laboratory animal allergens: stability of airway responsiveness to methacholine challenge for one year.
Topics: Adult; Allergens; Animals; Animals, Laboratory; Asthma; Bronchial Provocation Tests; Humans; Methacholine Chloride; Occupational Diseases; Prospective Studies; Risk Factors; Skin Tests; Time Factors | 1995 |
Beta-agonists and asthma.
Topics: Albuterol; Asthma; Bronchoconstriction; Bronchodilator Agents; Humans; Methacholine Chloride; Salmeterol Xinafoate | 1993 |
Inhalation of nitric oxide modulates adult human bronchial tone.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Airway Resistance; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Functional Residual Capacity; Humans; Lung Diseases, Obstructive; Male; Methacholine Chloride; Methemoglobinemia; Middle Aged; Nitric Oxide; Oxygen | 1993 |
Bronchial asthma and hyperreactivity after early childhood bronchiolitis or pneumonia. An 8-year follow-up study.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchiolitis; Child; Follow-Up Studies; Humans; Infant; Methacholine Chloride; Pneumonia; Risk Factors | 1994 |
Bronchial hyperresponsiveness can improve while spirometry plateaus two to three years after repeated exposure to chlorine causing respiratory symptoms.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Canada; Chlorine; Humans; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Occupational Exposure; Paper; Spirometry; Time Factors | 1994 |
Nonspecific and specific bronchial responsiveness in occupational asthma caused by platinum salts after allergen avoidance.
Topics: Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Humans; Methacholine Chloride; Multivariate Analysis; Occupational Diseases; Occupational Exposure; Platinum Compounds; Skin Tests; Time Factors | 1994 |
Acute bronchial and hematologic effects following inhalation of a single dose of PAF. Comparison between asthmatics and normal subjects.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Leukocyte Count; Male; Methacholine Chloride; Monocytes; Neutrophils; Platelet Activating Factor; Time Factors | 1994 |
Clinical and functional characteristics of patients two years after being affected by the soybean asthma epidemic in Barcelona.
Topics: Asthma; Bronchial Provocation Tests; Case-Control Studies; Disease Outbreaks; Dust; Female; Follow-Up Studies; Glycine max; Humans; Hypersensitivity; Immunoglobulin E; Lung; Male; Methacholine Chloride; Middle Aged; Spain; Spirometry | 1994 |
Effect of posture on bronchial reactivity to inhaled methacholine in patients with mitral valve stenosis.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dyspnea, Paroxysmal; Female; Humans; Male; Methacholine Chloride; Middle Aged; Mitral Valve Stenosis; Respiratory Function Tests; Supine Position; Time Factors | 1994 |
Bronchial asthma, rhinoconjunctivitis, and contact dermatitis caused by onion.
Topics: Adult; Allium; Asthma; Bronchial Provocation Tests; Conjunctivitis; Dermatitis, Contact; Female; Forced Expiratory Volume; Humans; Immunoglobulin E; Male; Methacholine Chloride; Middle Aged; Nasal Provocation Tests; Plant Extracts; Rhinitis | 1994 |
Methacholine inhalation challenge.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Contraindications; Forced Expiratory Volume; Humans; Methacholine Chloride | 1994 |
Perception of airflow obstruction and associated breathlessness in normal and asthmatic subjects: correlation with anxiety and bronchodilator needs.
Topics: Adult; Airway Obstruction; Anxiety; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Perception | 1994 |
The bronchial response, but not the pulmonary response to inhaled methacholine is dependent on the aerosol deposition pattern.
Topics: Adult; Aerosols; Airway Resistance; Asthma; Blood Gas Analysis; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Humans; Lung; Male; Methacholine Chloride; Pulmonary Gas Exchange; Radionuclide Imaging; Technetium Tc 99m Pentetate; Ventilation-Perfusion Ratio | 1994 |
Tracheal wheezes during methacholine airway challenge (MAC) in workers exposed to occupational hazards.
Topics: Adult; Asthma; Auscultation; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dust; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Occupational Diseases; Predictive Value of Tests; Respiratory Sounds; Sensitivity and Specificity; Spirometry; Tracheal Diseases | 1994 |
[Relations between nonspecific bronchial hyperreactivity, diurnal variation of peak expiratory flow and medication requirements in patients with mild asthma].
Topics: Adolescent; Adult; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchodilator Agents; Circadian Rhythm; Female; Humans; Male; Methacholine Chloride; Peak Expiratory Flow Rate | 1994 |
Dietary sodium intake, airway responsiveness, and cellular sodium transport.
Topics: Adolescent; Adult; Analysis of Variance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Case-Control Studies; Confounding Factors, Epidemiologic; Furosemide; Humans; Intracellular Fluid; Leukocytes; Likelihood Functions; Male; Methacholine Chloride; Regression Analysis; Risk Factors; Sodium; Sodium-Potassium-Exchanging ATPase; Sodium, Dietary; Time Factors | 1994 |
Effective allergen avoidance at high altitude reduces allergen-induced bronchial hyperresponsiveness.
Topics: Allergens; Altitude; Analysis of Variance; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Cohort Studies; Dust; Environmental Monitoring; Epidemiological Monitoring; Exercise Test; Forced Expiratory Volume; Histamine; Humans; Hypersensitivity; Immunoglobulin E; Methacholine Chloride; Mites; Peak Expiratory Flow Rate; Primary Prevention; Recurrence; Residence Characteristics; Residential Facilities; Seasons; Skin Tests; Time Factors | 1994 |
Involvement of thromboxane A2 in propranolol-induced bronchoconstriction after allergic bronchoconstriction in guinea pigs.
Topics: Administration, Inhalation; Analysis of Variance; Animals; Asthma; Bridged Bicyclo Compounds; Bronchial Provocation Tests; Constriction, Pathologic; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Guinea Pigs; Hypersensitivity; Inflammation; Injections, Intravenous; Male; Methacholine Chloride; Premedication; Propranolol; Receptors, Prostaglandin; Thromboxane A2; Time Factors | 1994 |
Airway inflammation in symptomatic and asymptomatic children with methacholine hyperresponsiveness.
Topics: Adult; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Humans; Methacholine Chloride | 1994 |
Measurement of bronchial responsiveness by forced oscillation technique in occupational epidemiology.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Sectional Studies; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Occupational Diseases; Respiratory Function Tests; ROC Curve; Sensitivity and Specificity; Tunisia | 1994 |
Virus-induced airway obstruction and parasympathetic hyperresponsiveness in adult rats.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Electric Stimulation; Gallamine Triethiodide; Male; Methacholine Chloride; Muscarinic Antagonists; Parainfluenza Virus 1, Human; Paramyxoviridae Infections; Parasympathetic Nervous System; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Respiratory Mechanics; Respiratory Tract Infections; Vagus Nerve | 1994 |
Prognostic value of methacholine challenge in patients with respiratory symptoms.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Prognosis; Respiratory Hypersensitivity; Surveys and Questionnaires; Vital Capacity | 1994 |
Changes in residual volume during induced bronchoconstriction in healthy and asthmatic subjects.
Topics: Adult; Allergens; Animals; Antigens, Dermatophagoides; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Female; Forced Expiratory Flow Rates; Forced Expiratory Volume; Glycoproteins; Humans; Male; Methacholine Chloride; Residual Volume; Vital Capacity | 1994 |
Acute pulmonary response of asthmatics to aerosols and gases generated by airbag deployment.
Topics: Adolescent; Adult; Aerosols; Air Bags; Airway Resistance; Asthma; Bronchial Provocation Tests; Female; Functional Residual Capacity; Gases; Humans; Male; Methacholine Chloride; Middle Aged; Particle Size; Total Lung Capacity | 1994 |
Extrapolation of methacholine log-dose response curves with a Cumulative Gaussian Distribution function.
Topics: Adult; Asthma; Bronchial Provocation Tests; Female; Humans; Linear Models; Male; Methacholine Chloride; Middle Aged; Models, Biological; Normal Distribution | 1994 |
[Nonspecific inhalative provocation in the sheep as an asthma model--correlation of respiratory and cardiovascular effects].
Topics: Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Carbon Dioxide; Disease Models, Animal; Dose-Response Relationship, Drug; Lung Volume Measurements; Methacholine Chloride; Oxygen; Pulmonary Wedge Pressure; Sheep; Ventilation-Perfusion Ratio | 1994 |
Perceived symptoms and discomfort during induced bronchospasm: the role of temporal adaptation and anxiety.
Topics: Adaptation, Psychological; Adult; Anxiety; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Sick Role | 1994 |
Comparison of circadian variations using FEV1 and peak expiratory flow rates among normal and asthmatic subjects.
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Child; Circadian Rhythm; Dose-Response Relationship, Drug; Forced Expiratory Volume; Humans; Lung; Methacholine Chloride; Peak Expiratory Flow Rate | 1994 |
Quantitative analysis of peripheral allergen-specific B lymphocytes in asthma.
Topics: Administration, Inhalation; Adolescent; Adult; Allergens; Animals; Asthma; B-Lymphocytes; Bronchial Provocation Tests; Culture Techniques; Dust; Female; Herpesvirus 4, Human; Humans; Immunoglobulin E; Lymphocyte Activation; Male; Methacholine Chloride; Mites; Neutrophils; Radioallergosorbent Test; Reaction Time; Respiratory Function Tests | 1994 |
The FEF25-75% and the clinical diagnosis of asthma.
Topics: Adolescent; Adult; Aged; Asthma; Bronchi; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Maximal Midexpiratory Flow Rate; Methacholine Chloride; Middle Aged; Predictive Value of Tests; Sensitivity and Specificity; Spirometry | 1994 |
Bronchoprovocation test by forced oscillation technique: airway hyperresponsiveness in chronic cough and psychogenic dyspnea subjects.
Topics: Adult; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Chronic Disease; Cough; Dyspnea; High-Frequency Ventilation; Humans; Methacholine Chloride | 1993 |
Comparison of bronchial reactivity to ultrasonically nebulized distilled water, exercise and methacholine challenge test in asthmatic children.
Topics: Administration, Inhalation; Adolescent; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Child; Exercise; Female; Humans; Male; Methacholine Chloride; Water | 1994 |
Outcome of wheeze in childhood. Symptoms and pulmonary function 25 years later.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Case-Control Studies; Child; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Odds Ratio; Prognosis; Respiratory Sounds; Respiratory Tract Infections; Sex Factors; Smoking; Sputum | 1994 |
Inhaled beclomethasone dipropionate downregulates airway lymphocyte activation in atopic asthma.
Topics: Administration, Inhalation; Adult; Asthma; Beclomethasone; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Female; HLA-DR Antigens; Humans; Hypersensitivity, Immediate; Immunophenotyping; Leukocyte Count; Lymphocyte Activation; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Receptors, Interleukin-2; Regression Analysis; Severity of Illness Index; T-Lymphocytes | 1994 |
Evaluation of peak expiratory flow variability in an adolescent population sample. The Odense Schoolchild Study.
Topics: Adolescent; Analysis of Variance; Asthma; Bronchial Provocation Tests; Denmark; Dose-Response Relationship, Drug; Exercise Test; Female; Humans; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Population Surveillance; Prospective Studies; Reproducibility of Results; Risk Factors; Sampling Studies; Sensitivity and Specificity | 1994 |
Predictive value of airways hyperresponsiveness and circulating IgE for identifying types of responses to toluene diisocyanate inhalation challenge.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Chi-Square Distribution; Female; Forced Expiratory Volume; Humans; Immunoglobulin E; Immunoglobulin G; Male; Methacholine Chloride; Occupational Diseases; Predictive Value of Tests; Reproducibility of Results; Skin Tests; Toluene 2,4-Diisocyanate | 1994 |
Relationship of plasma epinephrine and circulating eosinophils to nocturnal asthma.
Topics: Adult; Airway Obstruction; Analysis of Variance; Asthma; Bronchial Provocation Tests; Circadian Rhythm; Eosinophils; Epinephrine; Female; Forced Expiratory Volume; Histamine; Humans; Hydrocortisone; Leukocyte Count; Male; Methacholine Chloride; Severity of Illness Index | 1994 |
Asthma caused by live fish bait.
Topics: Adolescent; Adult; Animals; Asthma; Conjunctivitis, Allergic; Diptera; Fishes; Forced Expiratory Volume; Humans; Larva; Male; Methacholine Chloride; Middle Aged; Moths; Occupational Exposure; Peak Expiratory Flow Rate; Radioallergosorbent Test; Rhinitis, Allergic, Perennial; Skin Tests; Tenebrio; Urticaria | 1994 |
Bronchial hyperresponsiveness and toluene diisocyanate. Long-term change in sensitized asthmatic subjects.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Time Factors; Toluene 2,4-Diisocyanate | 1993 |
Normal range of methacholine responsiveness in relation to prechallenge pulmonary function. The Normative Aging Study.
Topics: Adult; Aged; Aging; Asthma; Bronchial Provocation Tests; Cohort Studies; Forced Expiratory Volume; Humans; Linear Models; Longitudinal Studies; Male; Methacholine Chloride; Middle Aged; Reference Values; Sensitivity and Specificity; Vital Capacity | 1994 |
Peripheral mononuclear leucocyte beta adrenoceptors and non-specific bronchial responsiveness to methacholine in young and elderly normal subjects and asthmatic patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Asthma; Bronchi; Bronchial Provocation Tests; Epinephrine; Female; Forced Expiratory Flow Rates; Humans; Immunoglobulin E; Leukocytes, Mononuclear; Male; Methacholine Chloride; Middle Aged; Norepinephrine; Receptors, Adrenergic, beta | 1994 |
Persistence of airway obstruction and hyperresponsiveness in subjects with asthma remission.
Topics: Adolescent; Adult; Aged; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Female; Forced Expiratory Volume; Humans; Lung Volume Measurements; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Vital Capacity | 1994 |
Retrospective analyses of methacholine inhalation challenges.
Topics: Adolescent; Adult; Aged; Asthma; Bronchial Provocation Tests; Child; Female; Humans; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests; Respiratory Mechanics; Retrospective Studies; Sensitivity and Specificity | 1994 |
Occupational asthma caused by milk proteins: report on a case.
Topics: Asthma; Bronchial Provocation Tests; Forced Expiratory Volume; Humans; Immunoglobulin E; Male; Methacholine Chloride; Middle Aged; Milk Hypersensitivity; Milk Proteins; Occupational Diseases; Radioallergosorbent Test; Skin Tests | 1994 |
Cough variant asthma: a case study with antigen, histamine and methacholine inhalation challenge tests.
Topics: Asthma; Bronchial Provocation Tests; Child; Cough; Dust; Female; Histamine; Humans; Methacholine Chloride | 1994 |
Airway responsiveness to methacholine and risk of asthma in patients with allergic rhinitis.
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Rhinitis, Allergic, Perennial; Risk Factors | 1994 |
Pronounced bronchial hyper-responsiveness and asthma severity.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Middle Aged; Prognosis; Prospective Studies; Retrospective Studies; Spirometry | 1994 |
Transcutaneous partial oxygen tension and lung mechanics during methacholine inhaled challenge.
Topics: Adult; Asthma; Blood Gas Monitoring, Transcutaneous; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Respiratory Mechanics | 1994 |
Cough variant asthma is associated with a higher wheezing threshold than classic asthma.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Child; Cough; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Respiratory Sounds; Sensory Thresholds | 1993 |
Bronchoprovocation challenge. A clinical test whose time has come.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Humans; Methacholine Chloride | 1993 |
Bronchoconstrictive responses to inhaled ultrasonically nebulized distilled water and airway inflammation in asthma.
Topics: Adult; Asthma; Biopsy; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoscopy; Female; Forced Expiratory Volume; Histocytochemistry; Humans; Immunohistochemistry; Male; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers; Peak Expiratory Flow Rate; Ultrasonics; Water | 1993 |
Effects of inhaled capsaicin in heart-lung transplant patients and asthmatic subjects.
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Bronchi; Bronchial Provocation Tests; Capsaicin; Forced Expiratory Volume; Heart-Lung Transplantation; Humans; Methacholine Chloride; Middle Aged | 1993 |
Breathlessness during acute bronchoconstriction in asthma. Pathophysiologic mechanisms.
Topics: Acute Disease; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Dyspnea; Female; Humans; Male; Methacholine Chloride; Pulmonary Ventilation; Spirometry | 1993 |
Neutral endopeptidase activity and airway hyperresponsiveness to neurokinin A in asthmatic subjects in vivo.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Double-Blind Method; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Neprilysin; Neurokinin A; Thiorphan | 1993 |
Bronchial responsiveness to inhaled metabisulfite in asthmatic children increases with age.
Topics: Adolescent; Adult; Age Factors; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Child; Child, Preschool; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Sulfites | 1993 |
Effect of calcium channel antagonists on cholinergic bronchial responsiveness in asthma.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Calcium Channel Blockers; Diltiazem; Humans; Methacholine Chloride; Nifedipine | 1993 |
Predictors of longitudinal change in methacholine airway responsiveness among middle-aged and older men: the Normative Aging Study.
Topics: Aged; Aging; Asthma; Basophils; Boston; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cohort Studies; Humans; Linear Models; Longitudinal Studies; Male; Methacholine Chloride; Middle Aged; Smoking; Time Factors | 1994 |
Airway responsiveness in young black and white women.
Topics: Adult; Analysis of Variance; Asthma; Black People; Boston; Bronchi; Bronchial Provocation Tests; Case-Control Studies; Chi-Square Distribution; Female; Humans; Immunoglobulin E; Methacholine Chloride; Postpartum Period; Pregnancy; Prognosis; Smoking; Socioeconomic Factors; Spirometry; White People | 1993 |
Diagnostic value of the bronchial provocation test with methacholine in asthma. A Bayesian analysis approach.
Topics: Adult; Asthma; Bayes Theorem; Bronchial Provocation Tests; Bronchitis; Chronic Disease; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Probability; Rhinitis; ROC Curve; Sensitivity and Specificity; Smoking | 1993 |
Evaluation of a worker with possible formaldehyde-induced asthma.
Topics: Asthma; Bronchial Provocation Tests; Bronchial Spasm; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Formaldehyde; Humans; Immunoglobulin E; Immunoglobulin G; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Skin Tests; Time Factors | 1993 |
Atrial natriuretic peptide and bronchial hyperresponsiveness in patients with mitral stenosis.
Topics: Adult; Asthma; Atrial Natriuretic Factor; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Middle Aged; Mitral Valve Stenosis | 1993 |
Responses of plasma vasoactive intestinal polypeptide to methacholine and exercise loading in children and adolescents with bronchial asthma.
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Child; Exercise; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Vasoactive Intestinal Peptide | 1993 |
Relationships among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cytokines; Female; Humans; In Situ Hybridization; Male; Methacholine Chloride; RNA, Messenger | 1993 |
[Bronchial provocation test in bronchial asthma].
Topics: Aspirin; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cough; Humans; Methacholine Chloride | 1993 |
Does baseline airway caliber affect measurements of airway responsiveness to histamine.
Topics: Adult; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoconstriction; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride | 1993 |
Factors contributing to dyspnoea during bronchoconstriction and exercise in asthmatic subjects.
Topics: Adult; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Bronchoconstriction; Dyspnea; Exercise Test; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Respiratory Muscles | 1993 |
Tracheal size is a determinant of the bronchoconstrictive response to inhaled methacholine.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Cross-Sectional Studies; Humans; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Smoking; Trachea | 1993 |
Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects.
Topics: Adult; Aged; Amino Acid Sequence; Asthma; Cell Membrane; Genetic Carrier Screening; Humans; Methacholine Chloride; Middle Aged; Models, Structural; Molecular Sequence Data; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Protein Conformation; Receptors, Adrenergic, beta; Reference Values | 1993 |
Cysteinyl leukotrienes overproduction and mast cell activation in aspirin-provoked bronchospasm in asthma.
Topics: Adult; Aspirin; Asthma; Blood Proteins; Bronchial Provocation Tests; Bronchoconstriction; Chymases; Eosinophil Granule Proteins; Eosinophils; Female; Humans; Leukotriene E4; Male; Mast Cells; Methacholine Chloride; Middle Aged; Ribonucleases; Serine Endopeptidases; SRS-A; Thromboxane B2; Tryptases | 1993 |
Increased LTB4 metabolites and PGD2 in BAL fluid after methacholine challenge in asthmatic subjects.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoscopy; Eosinophils; Female; Humans; Leukocyte Count; Leukotriene B4; Male; Methacholine Chloride; Prostaglandin D2; Time Factors | 1993 |
Response to isocyanates: effect of concentration, duration of exposure, and dose.
Topics: Adult; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Toluene 2,4-Diisocyanate | 1993 |
Bronchial responsiveness to ultrasonic fog in occupational asthma due to toluene diisocyanate.
Topics: Adult; Aerosols; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Occupational Diseases; Sensitivity and Specificity; Toluene 2,4-Diisocyanate; Ultrasonics; Water | 1993 |
Acoustic vs. spirometric assessment of bronchial responsiveness to methacholine in children.
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Child; Diagnosis, Computer-Assisted; Female; Humans; Male; Methacholine Chloride; Regression Analysis; Respiratory Sounds; Spirometry | 1993 |
Lung function and bronchial response to methacholine in young adults who had asthma in childhood.
Topics: Adolescent; Adult; Asthma; Bronchi; Family Health; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Rhinitis | 1993 |
Predictors of the new onset of wheezing among middle-aged and older men. The Normative Aging Study.
Topics: Adult; Aged; Aged, 80 and over; Aging; Asthma; Boston; Humans; Immunoglobulin E; Male; Methacholine Chloride; Middle Aged; Prognosis; Prospective Studies; Regression Analysis; Respiratory Sounds; Risk Factors; Skin Tests; Spirometry; Surveys and Questionnaires | 1993 |
Circadian variation in airway responsiveness to methacholine, propranolol, and AMP in atopic asthmatic subjects.
Topics: Adenosine Monophosphate; Adult; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Circadian Rhythm; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Propranolol; Prospective Studies; Spirometry; Time Factors | 1993 |
Airway responsiveness to adenosine 5'-monophosphate in chronic obstructive pulmonary disease is determined by smoking.
Topics: Adenosine Monophosphate; Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Lung Diseases, Obstructive; Male; Methacholine Chloride; Middle Aged; Smoking | 1993 |
Bronchial responsiveness to inhaled propranolol in asthmatic children and adults.
Topics: Administration, Inhalation; Adult; Aerosols; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Propranolol; Reproducibility of Results | 1993 |
Assessment of therapeutic benefit in asthmatic patients. The International Clinical Respiratory Group.
Topics: Asthma; Bronchial Provocation Tests; Evaluation Studies as Topic; Exercise Test; Humans; Lung; Methacholine Chloride; Self Concept | 1993 |
Methacholine reactivity and asthma. Report from the Northern Sweden Obstructive Lung Disease Project.
Topics: Adult; Aged; Asthma; Bronchial Provocation Tests; Humans; Methacholine Chloride; Middle Aged | 1993 |
Modifications of PC20 and maximal degree of airway narrowing to methacholine after pollen season in pollen sensitive asthmatic patients.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Pollen | 1993 |
Mite asthma in childhood: a study of the relationship between exposure to house dust mites and disease activity.
Topics: Adolescent; Animals; Asthma; Child; Dust; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Mites | 1993 |
Influence of natural antigenic exposure on expiratory flows, methacholine responsiveness, and airway inflammation in mild allergic asthma.
Topics: Adult; Antigens; Asthma; Biopsy; Bronchi; Bronchitis; Bronchoalveolar Lavage Fluid; Female; Humans; Male; Maximal Expiratory Flow Rate; Methacholine Chloride; Microscopy, Electron | 1993 |
Altered platelet function associated with the bronchial hyperresponsiveness accompanying nocturnal asthma.
Topics: Adult; Asthma; beta-Thromboglobulin; Bronchi; Circadian Rhythm; Female; Humans; Male; Methacholine Chloride; Platelet Activation; Platelet Count; Platelet Factor 4 | 1993 |
Late phase bronchoconstriction and eosinophilia as well as methacholine hyperresponsiveness in Ascaris-sensitive rhesus monkeys were reversed by oral administration of U-83836E.
Topics: Animals; Ascaris; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Chromans; Eosinophilia; Female; Macaca mulatta; Methacholine Chloride; Piperazines | 1993 |
Changes in transcutaneous oxygen partial pressure as an index of response to inhaled methacholine in asthmatic patients.
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Oxygen; Partial Pressure | 1993 |
Changing patterns of aerosol deposition during methacholine bronchoprovocation.
Topics: Administration, Inhalation; Adolescent; Adult; Aerosols; Asthma; Bronchial Provocation Tests; Bronchospirometry; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Treatment Outcome | 1993 |
Respiratory symptoms and bronchial responsiveness are related to dietary salt intake and urinary potassium excretion in male children.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Cross-Sectional Studies; Humans; Male; Methacholine Chloride; Natriuresis; Potassium; Potassium, Dietary; Prevalence; Sodium, Dietary | 1993 |
Correlation of nonspecific bronchial responsiveness to baseline pulmonary function in patients with asthma and sinobronchial syndrome.
Topics: Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Sinusitis; Syndrome | 1993 |
Measurement of airway responsiveness to methacholine: relative importance of the precision of drug delivery and the method of assessing response.
Topics: Adolescent; Adult; Aged; Asthma; Bronchial Provocation Tests; Drug Delivery Systems; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Reproducibility of Results | 1993 |
Is the allergen-inhalation challenge predictive of the severity of seasonal asthmatic exacerbations?
Topics: Adolescent; Adult; Allergens; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Immunoglobulin E; Male; Methacholine Chloride; Pollen; Rhinitis, Allergic, Seasonal | 1993 |
[Ozone, respiratory function and bronchial reactivity. Study of a group of pre-Alpine agricultural workers].
Topics: Adult; Aged; Agriculture; Altitude; Asthma; Bronchial Provocation Tests; Humans; Male; Methacholine Chloride; Middle Aged; Ozone; Respiratory Function Tests; Spirometry | 1993 |
Peripheral airways responsiveness to cool, dry air in normal and asthmatic individuals.
Topics: Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoscopy; Cold Temperature; Forced Expiratory Volume; Humans; Humidity; Methacholine Chloride; Respiration | 1995 |
Effects of a thromboxane synthase inhibitor (CS-518) on the eosinophil-dependent late asthmatic response and airway hyperresponsiveness in guinea pigs.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Chemotaxis, Leukocyte; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eosinophils; Guinea Pigs; Male; Methacholine Chloride; Ovalbumin; Pulmonary Eosinophilia; Thiophenes; Thromboxane-A Synthase | 1996 |
Relationship between airway eosinophilia and airway hyperresponsiveness in a late asthmatic model of guinea pigs.
Topics: Animals; Antibodies; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Eosinophils; Guinea Pigs; Histamine; Interleukin-5; Leukocyte Count; Leukotriene C4; Male; Methacholine Chloride; Ovalbumin; Passive Cutaneous Anaphylaxis; Pulmonary Eosinophilia; Thromboxane B2; Time Factors | 1996 |
Effect of dietary sodium on airways responsiveness and its importance in the epidemiology of asthma: an evaluation in three areas of northern England.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; England; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Regression Analysis; Respiratory System; Sodium; Sodium, Dietary | 1995 |
Maximal bronchoconstriction in humans. Relationship to deep inhalation and airway sensitivity.
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Data Interpretation, Statistical; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Models, Biological; Muscle Contraction; Muscle, Smooth; Respiration; Respiratory Function Tests | 1996 |
Inhaled nitric oxide. A bronchodilator in mild asthmatics with methacholine-induced bronchospasm.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Bronchoconstrictor Agents; Bronchodilator Agents; Female; Forced Expiratory Volume; Humans; Isoproterenol; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Respiratory Function Tests; Spirometry | 1996 |
Airway responsiveness to bradykinin is related to eosinophilic inflammation in asthma.
Topics: Adult; Aged; Asthma; Biopsy; Bradykinin; Bronchi; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoscopy; Data Interpretation, Statistical; Eosinophils; Female; Humans; Lymphocytes; Macrophages; Male; Methacholine Chloride; Middle Aged; Neutrophils | 1996 |
Asthmatic risk factors and bronchial reactivity in non-diagnosed asthmatic adults.
Topics: Adult; Aged; Arizona; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Disease Progression; Disease Susceptibility; Female; Follow-Up Studies; Forecasting; Humans; Immunoglobulin E; Longitudinal Studies; Lung; Lung Diseases, Obstructive; Male; Methacholine Chloride; Middle Aged; Respiratory Sounds; Risk Factors | 1995 |
Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.
Topics: Aerosols; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophilia; Interleukin-5; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Ovalbumin; Respiratory System | 1996 |
[Chronic course of reactive bronchial dysfunction syndrome. Apropos of 6 further cases].
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Chlorine; Female; Humans; Irritants; Male; Methacholine Chloride; Middle Aged; Occupational Diseases | 1995 |
Detection of excessive bronchoconstriction in asthma.
Topics: Adult; Aged; Aged, 80 and over; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Middle Aged; Reproducibility of Results; Retrospective Studies; Spirometry; Vital Capacity | 1996 |
Airway hyper- or hyporeactivity to inhaled spasmogens 24 h after ovalbumin challenge of sensitized guinea-pigs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine; Administration, Inhalation; Airway Resistance; Animals; Asthma; Atropine; Bronchial Spasm; Bronchoconstrictor Agents; Bronchodilator Agents; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Male; Methacholine Chloride; Ovalbumin; Plethysmography, Whole Body; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1995 |
Increased peak flow variability in children with asymptomatic hyperresponsiveness.
Topics: Adolescent; Airway Obstruction; Asthma; Bronchial Hyperreactivity; Child; Circadian Rhythm; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Rhinitis | 1995 |
Allergy and the development of asthma and bronchial hyperresponsiveness.
Topics: Adult; Arizona; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Cohort Studies; Female; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Male; Methacholine Chloride; Middle Aged; New Zealand; Risk Factors; Skin Tests | 1995 |
Collaborative study on the genetics of asthma in Germany.
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Child, Preschool; Forced Expiratory Volume; Germany; Humans; Immunoglobulin E; Methacholine Chloride; Peak Expiratory Flow Rate; Pilot Projects; Polymerase Chain Reaction; Skin Tests | 1995 |
Concentrations of methacholine for bronchial responsiveness according to symptoms, smoking and immunoglobulin E in a population-based study in Spain. Spanish Group of the European Asthma Study.
Topics: Adult; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Immunoglobulin E; Life Tables; Male; Methacholine Chloride; Smoking; Spain | 1996 |
Prior diagnosis and treatment of patients with normal results of methacholine challenge and unexplained respiratory symptoms.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Diagnosis, Differential; Humans; Methacholine Chloride; Retrospective Studies | 1996 |
Bronchoprovocation tests in the diagnosis of isocyanate-induced asthma.
Topics: Asthma; Bronchial Provocation Tests; Humans; Isocyanates; Methacholine Chloride; Occupational Diseases; Peak Expiratory Flow Rate | 1996 |
Influence of allergen avoidance on the eosinophil phase of airway inflammation in children with allergic asthma.
Topics: Adolescent; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Environmental Exposure; Eosinophils; Female; Humans; Male; Methacholine Chloride; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sputum | 1996 |
In vitro and in vivo characterization of MDL 105,212A, a nonpeptide NK-1/NK-2 tachykinin receptor antagonist.
Topics: Amino Acid Sequence; Animals; Asthma; Bronchoconstriction; Capillary Permeability; Guinea Pigs; Humans; Inositol Phosphates; Male; Methacholine Chloride; Mice; Molecular Sequence Data; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrrolidines; Rats; Receptors, Neurokinin-2; Respiration; Species Specificity; Substance P | 1996 |
A longitudinal evaluation of bronchial responsiveness to methacholine in children: role of baseline lung function, gender, and change in atopic status.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Cohort Studies; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Hypersensitivity; Logistic Models; Longitudinal Studies; Lung; Male; Maximal Midexpiratory Flow Rate; Methacholine Chloride; Multivariate Analysis; Sex Characteristics; Skin Tests; Vital Capacity | 1996 |
Bronchial responsiveness to distilled water and methacholine and its relationship to inflammation and remodeling of the airways in asthma.
Topics: Adolescent; Adult; Asthma; Basement Membrane; Biopsy; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Bronchoconstrictor Agents; Eosinophils; Epithelium; Female; Forced Expiratory Volume; Humans; Inflammation; Leukocyte Count; Male; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers; Peak Expiratory Flow Rate; Water | 1996 |
Peroxynitrite induces airway hyperresponsiveness in guinea pigs in vitro and in vivo.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Eosinophils; Epithelium; Germ-Free Life; Guinea Pigs; Histamine; Inflammation Mediators; Male; Methacholine Chloride; Mucous Membrane; Nitrates; Time Factors; Trachea | 1996 |
Antigen-induced generation of lyso-phospholipids in human airways.
Topics: Adult; Asthma; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Dinoprost; Female; Gas Chromatography-Mass Spectrometry; Humans; Hypersensitivity; Lysophospholipids; Male; Methacholine Chloride; Prostaglandin D2; Reference Values; Rhinitis; Time Factors | 1996 |
Usual dietary salt intake and asthma in children: a case-control study.
Topics: Adolescent; Asthma; Bronchi; Bronchoconstrictor Agents; Case-Control Studies; Child; Child, Preschool; Diet Records; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Prevalence; Sodium Chloride, Dietary | 1996 |
Increased exhaled nitric oxide in asthma is mainly derived from the lower respiratory tract.
Topics: Adult; Analysis of Variance; Asthma; Breath Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Luminescent Measurements; Male; Methacholine Chloride; Nitric Oxide; Respiratory Function Tests; Respiratory System | 1996 |
Asthma on Tristan da Cunha: looking for the genetic link. The University of Toronto Genetics of Asthma Research Group.
Topics: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Allergens; Asthma; Atlantic Ocean; Bronchoconstrictor Agents; Child; Child, Preschool; Consanguinity; Female; Forced Expiratory Volume; Founder Effect; Genetic Linkage; Humans; Male; Methacholine Chloride; Middle Aged; Prevalence; Sex Distribution; Skin Tests | 1996 |
Effect of allergen avoidance at high altitude on direct and indirect bronchial hyperresponsiveness and markers of inflammation in children with allergic asthma.
Topics: Adenosine Monophosphate; Adolescent; Allergens; Altitude; Asthma; Blood Proteins; Bronchial Hyperreactivity; Child; Eosinophil Granule Proteins; Eosinophils; Female; Forced Expiratory Volume; Humans; Immunoglobulin E; Leukocyte Count; Male; Methacholine Chloride; Ribonucleases | 1996 |
Determination of post-salbutamol methacholine dose shift.
Topics: Adrenergic beta-Agonists; Albuterol; Asthma; Bronchial Provocation Tests; Humans; Methacholine Chloride | 1996 |
Asthma, airways responsiveness and air pollution in two contrasting districts of northern England.
Topics: Adult; Air Pollution; Asthma; Bronchoconstriction; Cross-Sectional Studies; England; Humans; Logistic Models; Male; Methacholine Chloride; Respiratory Sounds; Rural Health; Skin Tests; Socioeconomic Factors; Spirometry; Urban Health | 1996 |
Measurement of lung function in awake 2-4-year-old asthmatic children during methacholine challenge and acute asthma: a comparison of the impulse oscillation technique, the interrupter technique, and transcutaneous measurement of oxygen versus whole-body
Topics: Acute Disease; Airway Resistance; Asthma; Blood Gas Monitoring, Transcutaneous; Bronchial Provocation Tests; Bronchodilator Agents; Child, Preschool; Dose-Response Relationship, Drug; Humans; Methacholine Chloride; Oscillometry; Plethysmography, Whole Body; Respiratory Function Tests; Terbutaline | 1996 |
Prevalence of asthma in young cross-country skiers in central Scandinavia: differences between Norway and Sweden.
Topics: Adolescent; Adrenergic beta-Agonists; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Female; Humans; Male; Methacholine Chloride; Norway; Physical Endurance; Prevalence; Respiratory Hypersensitivity; Skiing; Spirometry; Sweden | 1996 |
Characterization of a primate model of asthma using anti-allergy/anti-asthma agents.
Topics: Albuterol; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Antigens; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Cetirizine; Dexamethasone; Disease Models, Animal; Leukocytes; Macaca fascicularis; Male; Methacholine Chloride; Pyrilamine; Salmeterol Xinafoate | 1996 |
The relationship between wheezing and lung mechanics during methacholine-induced bronchoconstriction in asthmatic subjects.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Fourier Analysis; Humans; Maximal Expiratory Flow-Volume Curves; Methacholine Chloride; Pulmonary Ventilation; Respiratory Mechanics; Respiratory Sounds; Signal Processing, Computer-Assisted; Tidal Volume | 1996 |
The effect of lifestyle on wheeze, atopy, and bronchial hyperreactivity in Asian and white children.
Topics: Asian People; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Diet; England; Female; Humans; Hypersensitivity, Immediate; Life Style; Male; Methacholine Chloride; Prevalence; Respiratory Sounds; Risk Factors; Skin Tests; Surveys and Questionnaires; White People | 1996 |
Methacholine inhaled challenge: study of correlation among different indices expressing the result.
Topics: Adult; Airway Resistance; Asthma; Blood Gas Monitoring, Transcutaneous; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Case-Control Studies; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Hypoxia; Male; Methacholine Chloride | 1996 |
Comparative influence of a single allergen exposure on the different components of airway response to methacholine.
Topics: Administration, Inhalation; Adult; Allergens; Asthma; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Respiratory Mechanics; Vital Capacity | 1996 |
Ventilatory response to continuous incremental changes in respiratory resistance in patients with mild asthma.
Topics: Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Female; Humans; Male; Methacholine Chloride; Oxygen; Plethysmography; Respiratory Mechanics | 1996 |
Absence of relationship between degree of nonspecific and specific bronchial responsiveness in occupational asthma due to platinum salts.
Topics: Adolescent; Adult; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Humans; Immunoglobulin E; Lung; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Occupational Exposure; Patch Tests; Platinum Compounds; Regression Analysis | 1996 |
Separation of airway and tissue properties by transfer respiratory impedance and thoracic gas volume in reversible airway obstruction.
Topics: Adolescent; Adult; Airway Obstruction; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Child; Electric Impedance; Humans; Lung Volume Measurements; Methacholine Chloride; Middle Aged; Pulmonary Ventilation | 1996 |
Use of tracheal auscultation for the assessment of bronchial responsiveness in asthmatic children.
Topics: Adolescent; Asthma; Auscultation; Bronchi; Bronchial Provocation Tests; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Respiratory Sounds | 1996 |
Comparison of early and late asthmatic responses between patients with allergic rhinitis and mild asthma.
Topics: Adolescent; Adult; Analysis of Variance; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Chi-Square Distribution; Dust; Female; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Male; Methacholine Chloride; Middle Aged; Pollen; Rhinitis, Allergic, Perennial; Surveys and Questionnaires | 1996 |
Respiratory sensation during bronchial challenge testing with methacholine, sodium metabisulphite, and adenosine monophosphate.
Topics: Adenosine Monophosphate; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Sensation; Sulfites; Surveys and Questionnaires | 1996 |
High-resolution computed tomography of airway changes after induced bronchoconstriction and bronchodilation in asthmatic volunteers.
Topics: Adult; Albuterol; Asthma; Bronchi; Bronchial Diseases; Bronchoconstrictor Agents; Bronchodilator Agents; Constriction, Pathologic; Dilatation; Female; Humans; Male; Methacholine Chloride; Respiratory Function Tests; Tomography, X-Ray Computed | 1996 |
Metaproterenol responsiveness after methacholine- and histamine-induced bronchoconstriction.
Topics: Adrenergic beta-Agonists; Analysis of Variance; Anthropometry; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Histamine; Humans; Metaproterenol; Methacholine Chloride | 1996 |
Exhaled nitric oxide during acute changes of airways calibre in asthma.
Topics: Adult; Airway Resistance; Albuterol; Analysis of Variance; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Female; Humans; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Reference Values; Respiration; Respiratory Function Tests | 1996 |
Comparison of respiratory inductance plethysmography with thoracoabdominal compression in bronchial challenges in infants and young children.
Topics: Airway Resistance; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Humans; Infant; Male; Maximal Expiratory Flow Rate; Maximal Expiratory Flow-Volume Curves; Methacholine Chloride; Peak Expiratory Flow Rate; Plethysmography; Pressure | 1996 |
Nonspecific bronchial hyperresponsiveness and development of asthma in children with hay fever.
Topics: Asthma; Bronchial Hyperreactivity; Child; Female; Follow-Up Studies; Humans; Immunoglobulin E; Male; Methacholine Chloride; Pollen; Predictive Value of Tests; Rhinitis, Allergic, Seasonal | 1995 |
Evaluation of a new interrupter device for measuring bronchial responsiveness and the response to bronchodilator in 3 year old children.
Topics: Airway Resistance; Albuterol; Asthma; Blood Gas Monitoring, Transcutaneous; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Child, Preschool; Evaluation Studies as Topic; Female; Humans; Male; Methacholine Chloride; Reproducibility of Results; Respiratory Function Tests | 1996 |
Acute bronchial obstruction following inhalation of PAF in asthmatic and normal subjects: comparison with methacholine.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Platelet Activating Factor; Tachyphylaxis | 1996 |
Hypersensitivity pneumonitis-like reaction and occupational asthma associated with 1,3-bis(isocyanatomethyl) cyclohexane pre-polymer.
Topics: Adult; Alveolitis, Extrinsic Allergic; Arthralgia; Asthma; Automobiles; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Chest Pain; Cough; Cyclohexanes; Dyspnea; Female; Humans; Isocyanates; Male; Methacholine Chloride; Middle Aged; Muscular Diseases; Nausea; Occupational Diseases; Paint; Polymers; Prevalence; Respiratory Sounds; Shivering | 1996 |
Repeatability of a rapid dosimetric method for methacholine challenge using a pocket turbine spirometer for FEV1 measurements.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers; Reproducibility of Results; Spirometry | 1996 |
Effect of age, height, and prechallenge respiratory resistance on bronchial hyperresponsiveness in childhood asthma using the forced oscillation technique.
Topics: Administration, Inhalation; Adolescent; Age Factors; Airway Resistance; Analysis of Variance; Asthma; Body Height; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Female; High-Frequency Ventilation; Humans; Male; Methacholine Chloride; Regression Analysis; Risk Factors | 1996 |
Respiratory system reactance as an indicator of the intrathoracic airway response to methacholine in children.
Topics: Adolescent; Airway Resistance; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Prognosis; Respiratory Function Tests; Sensitivity and Specificity | 1996 |
Eosinophil peroxidase: a new serum marker of atopy and bronchial hyper-responsiveness.
Topics: Adult; Asthma; Biomarkers; Bronchial Hyperreactivity; Eosinophil Peroxidase; Eosinophils; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Peroxidases; Sensitivity and Specificity; Skin Tests | 1996 |
Factors affecting oxygen saturation during methacholine challenge in a mixed population.
Topics: Adult; Aged; Aged, 80 and over; Asthma; Bronchial Provocation Tests; Bronchitis; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Lung; Lung Diseases; Male; Methacholine Chloride; Middle Aged; Oxygen; Regression Analysis; Smoking | 1996 |
Increased variability in bronchial responsiveness in aluminum potroom workers with work-related asthma-like symptoms.
Topics: Adult; Aluminum; Analysis of Variance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Sectional Studies; Humans; Longitudinal Studies; Male; Methacholine Chloride; Middle Aged; Occupational Diseases | 1996 |
The importance of leukotrienes in airway inflammation in a mouse model of asthma.
Topics: 5-Lipoxygenase-Activating Proteins; Allergens; Animals; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Carrier Proteins; Disease Models, Animal; Female; Immunoglobulin E; Inflammation; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Membrane Proteins; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucus; Ovalbumin; Pulmonary Eosinophilia; Respiratory Function Tests; Respiratory System | 1996 |
Total serum IgE is associated with asthma independently of specific IgE levels. The Spanish Group of the European Study of Asthma.
Topics: Adult; Age Factors; Allergens; Animals; Animals, Domestic; Antibodies; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cohort Studies; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Fungi; Humans; Hypersensitivity; Immunoglobulin E; Male; Methacholine Chloride; Mites; Respiratory Sounds; Sex Factors; Smoking; Spain; Spirometry; Surveys and Questionnaires | 1996 |
Magnitude and determinants of short-term tachyphylaxis to methacholine in subjects with symptomatic or asymptomatic airway hyperresponsiveness and in normal controls.
Topics: Asthma; Bronchoconstrictor Agents; Eosinophils; Female; Humans; Immunoglobulin E; Leukocyte Count; Male; Methacholine Chloride; Respiratory Hypersensitivity; Skin Tests; Tachyphylaxis | 1996 |
Differences in the effect of allergen avoidance on bronchial hyperresponsiveness as measured by methacholine, adenosine 5'-monophosphate, and exercise in asthmatic children.
Topics: Adenosine Monophosphate; Adolescent; Allergens; Altitude; Animals; Asthma; Asthma, Exercise-Induced; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Environment, Controlled; Exercise Test; Female; Humans; Male; Methacholine Chloride; Mites | 1996 |
Increased prevalence of sleep disturbances and daytime sleepiness in subjects with bronchial asthma: a population study of young adults in three European countries.
Topics: Adult; Asthma; Belgium; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Confounding Factors, Epidemiologic; European Union; Humans; Iceland; Interviews as Topic; Methacholine Chloride; Middle Aged; Odds Ratio; Peak Expiratory Flow Rate; Population; Prevalence; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Skin Tests; Sleep Stages; Sleep Wake Disorders; Snoring; Surveys and Questionnaires; Sweden; Wakefulness | 1996 |
Effects of lung volume and thoracic gas compression on maximal and partial flow-volume curves.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Inhalation; Linear Models; Lung; Lung Volume Measurements; Maximal Expiratory Flow-Volume Curves; Methacholine Chloride; Middle Aged; Mouth; Plethysmography; Respiratory Mechanics; Thorax; Vital Capacity | 1996 |
BAL neutrophilia in asthmatic patients. A by-product of eosinophil recruitment?
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cell Count; Cell Movement; Cilia; Eosinophilia; Eosinophils; Epithelium; Female; Humans; Hypersensitivity; Leukocytosis; Lung; Male; Methacholine Chloride; Middle Aged; Neutrophil Activation; Neutrophils; Peroxidase | 1996 |
Bronchial responsiveness to ultrasonic "fog" in occupational asthma due to low molecular weight chemicals.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Methacholine Chloride; Molecular Weight; Nebulizers and Vaporizers; Occupational Diseases; Pharmaceutical Preparations; Respiratory Function Tests | 1996 |
Deficiency of nitric oxide in allergen-induced airway hyperreactivity to contractile agonists after the early asthmatic reaction: an ex vivo study.
Topics: Allergens; Animals; Asthma; Guinea Pigs; In Vitro Techniques; Methacholine Chloride; Muscle Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Trachea | 1996 |
In vitro T-lymphocyte response and house dust mite-induced bronchoconstriction.
Topics: Animals; Asthma; Bronchial Provocation Tests; Bronchoconstriction; CD4-Positive T-Lymphocytes; Cells, Cultured; Dust; Forced Expiratory Volume; Hypersensitivity, Immediate; Lymphocyte Activation; Lymphokines; Methacholine Chloride; Mites; Receptors, Interleukin-2 | 1996 |
Airway responsiveness and atopy in families of patients with asthma.
Topics: Adult; Allergens; Asthma; Eosinophils; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Leukocyte Count; Male; Methacholine Chloride; Skin Tests | 1996 |
Effect of dexamethasone and endogenous corticosterone on airway hyperresponsiveness and eosinophilia in the mouse.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Corticosterone; Dexamethasone; Eosinophilia; Immunoglobulin E; In Vitro Techniques; Male; Methacholine Chloride; Metyrapone; Mice; Mice, Inbred BALB C; Ovalbumin | 1996 |
Bronchial responsiveness of aged asthmatic patients to bronchodilator and methacholine.
Topics: Adult; Aging; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchodilator Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Vital Capacity | 1996 |
Comparison between hypertonic and isotonic saline-induced sputum in the evaluation of airway inflammation in subjects with moderate asthma.
Topics: Adolescent; Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Isotonic Solutions; Leukocyte Count; Leukocytes; Male; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers; Saline Solution, Hypertonic; Sodium Chloride; Sputum | 1996 |
Phospholipase A2 and arachidonate increase in bronchoalveolar lavage fluid after inhaled antigen challenge in asthmatics.
Topics: Arachidonic Acid; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Gas Chromatography-Mass Spectrometry; Humans; Methacholine Chloride; Phospholipases A; Phospholipases A2; Respiratory Function Tests | 1997 |
Chest surface mapping of lung sounds during methacholine challenge.
Topics: Adolescent; Analysis of Variance; Asthma; Bronchial Provocation Tests; Child; Forced Expiratory Volume; Humans; Linear Models; Male; Methacholine Chloride; Reference Values; Respiratory Sounds; Sensitivity and Specificity; Signal Processing, Computer-Assisted; Sound Spectrography | 1997 |
Factors relating to the severity of symptoms at 5 yrs in children with severe wheeze in the first 2 yrs of life.
Topics: Acute Disease; Airway Resistance; Asthma; Bronchial Provocation Tests; Child, Preschool; Female; Follow-Up Studies; Hospitalization; Humans; Hypersensitivity; Male; Methacholine Chloride; Prospective Studies; Regression Analysis; Respiratory Sounds | 1997 |
Bronchial reactivity and dietary antioxidants.
Topics: Adult; Antioxidants; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cross-Sectional Studies; Diet; Diet Surveys; Energy Intake; Female; Humans; Hypersensitivity; Male; Methacholine Chloride; Minerals; Odds Ratio; Rural Population; Scotland; Skin Tests; Vitamins | 1997 |
Blood markers of early and late airway responses to allergen in asthmatic subjects. Relationship with functional findings.
Topics: Adolescent; Adult; Allergens; Asthma; Biomarkers; Blood Proteins; Bronchial Provocation Tests; Chemotaxis, Leukocyte; Eosinophil Granule Proteins; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Middle Aged; Neutrophils; Respiratory Function Tests; Ribonucleases | 1997 |
Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration.
Topics: Administration, Inhalation; Aerosols; Animals; Antibodies, Monoclonal; Antigens; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophil Peroxidase; Eosinophils; Interferon-gamma; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Peroxidases | 1997 |
[Tachyphylaxis of airway response to inhaled bradykinin over several days].
Topics: Aerosols; Asthma; Bradykinin; Bronchial Provocation Tests; Bronchoconstriction; Drug Administration Schedule; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride | 1996 |
Comparison between peak expiratory flow and forced expiratory volume in one second (FEV1) during bronchoconstriction induced by different stimuli.
Topics: Allergens; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Exercise Test; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Nebulizers and Vaporizers; Peak Expiratory Flow Rate; Regression Analysis; Sensitivity and Specificity; Toluene 2,4-Diisocyanate; Water | 1997 |
T lymphocytes: setting the tone of the airways.
Topics: Animals; Asthma; Bone Marrow Transplantation; Methacholine Chloride; Mice; Mice, Inbred C57BL; Respiratory System; Species Specificity; T-Lymphocytes | 1997 |
T-lymphocytes regulate genetically determined airway hyperresponsiveness in mice.
Topics: Adoptive Transfer; Airway Resistance; Animals; Asthma; Bone Marrow Transplantation; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Lymphocyte Depletion; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Models, Biological; Respiratory System; Species Specificity; T-Lymphocytes; Thymectomy | 1997 |
Hyperpnea-induced changes in parenchymal lung mechanics in normal subjects and in asthmatics.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Case-Control Studies; Female; Humans; Male; Methacholine Chloride; Muscle, Smooth; Pulmonary Ventilation; Respiratory Mechanics | 1997 |
Airways remodeling is a distinctive feature of asthma and is related to severity of disease.
Topics: Adolescent; Adult; Asthma; Biopsy; Bronchi; Bronchial Provocation Tests; Bronchoscopy; Epithelium; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Regression Analysis; Severity of Illness Index | 1997 |
A short protocol for methacholine provocation testing adapted to the Rosenthal-Chai dosimeter technique.
Topics: Adult; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride | 1997 |
Priming of eosinophil adhesion in patients with birch pollen allergy during pollen season: effect of immunotherapy.
Topics: Adult; Asthma; Bronchial Provocation Tests; Cell Adhesion; Conjunctivitis, Allergic; Desensitization, Immunologic; Double-Blind Method; E-Selectin; Eosinophils; Female; Humans; Intercellular Adhesion Molecule-1; Male; Methacholine Chloride; Pollen; Rhinitis, Allergic, Seasonal; Vascular Cell Adhesion Molecule-1 | 1997 |
Prevalence of bronchial hyperreactivity as determined by several methods among Estonian schoolchildren.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Estonia; Exercise Test; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Methacholine Chloride; Peak Expiratory Flow Rate; Schools; Skin Tests; Surveys and Questionnaires | 1996 |
Lung auscultation in airway challenge testing.
Topics: Adolescent; Adult; Asthma; Auscultation; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Observer Variation; Respiratory Sounds; Spirometry; Stethoscopes | 1997 |
Repeatability of methacholine challenges in 2- to 4-year-old children with asthma, using a new technique for quantitative delivery of aerosol.
Topics: Aerosols; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child, Preschool; Female; Humans; Male; Methacholine Chloride; Reproducibility of Results; Terbutaline | 1997 |
Lung epithelial permeability and bronchial responsiveness in subjects with stable asthma.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Epithelium; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Permeability; Pulmonary Alveoli; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Pentetate | 1997 |
Augmentation of parasympathetic nerve function in patients with extrinsic bronchial asthma--evaluation by coefficiency of variance of R-R interval with modified long-term ECG monitoring system.
Topics: Adult; Asthma; Bronchial Provocation Tests; Electrocardiography, Ambulatory; Female; Humans; Male; Methacholine Chloride; Middle Aged; Parasympathetic Nervous System | 1996 |
[Study of spontaneous resolution of bronchial spasm after methacholine challenge. Comparison of patients with different degree of hyperreactivity].
Topics: Adult; Analysis of Variance; Asthma; Bronchial Hyperreactivity; Bronchial Spasm; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Time Factors | 1997 |
Asthma, bronchial hyperreactivity and mediator release in children with birch pollinosis. ECP and EPX levels are not related to bronchial hyperreactivity.
Topics: Adolescent; Asthma; Blood Proteins; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Chymases; Conjunctiva; Eosinophil Granule Proteins; Eosinophil-Derived Neurotoxin; Female; Humans; Inflammation; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Peroxidase; Pollen; Ribonucleases; Seasons; Serine Endopeptidases; Skin Tests; Trees; Tryptases | 1997 |
Comparison of the ISAAC video questionnaire (AVQ3.0) with the ISAAC written questionnaire for estimating asthma associated with bronchial hyperreactivity.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; China; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Prevalence; Respiratory Sounds; Sensitivity and Specificity; Severity of Illness Index; Surveys and Questionnaires; Videotape Recording | 1997 |
Vital capacities in acute and chronic airway obstruction: dependence on flow and volume histories.
Topics: Acute Disease; Asthma; Bronchial Provocation Tests; Forced Expiratory Volume; Humans; Lung Diseases, Obstructive; Lung Volume Measurements; Methacholine Chloride; Middle Aged; Pulmonary Ventilation; Residual Volume; Vital Capacity | 1997 |
Methacholine dose-response slopes from maximal bronchial challenge tests in asthmatic children: methodological aspects.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Least-Squares Analysis; Male; Methacholine Chloride; Predictive Value of Tests | 1997 |
Bronchial subepithelial fibrosis correlates with airway responsiveness to methacholine.
Topics: Adult; Asthma; Biopsy; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Chronic Disease; Collagen; Cough; Female; Fibrosis; Humans; Male; Methacholine Chloride; Occupational Diseases; Rhinitis, Allergic, Perennial | 1997 |
Methacholine challenge testing: safety of low starting FEV1. Asthma Clinical Research Network (ACRN).
Topics: Adrenergic beta-Agonists; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Retrospective Studies; Safety | 1997 |
Sensitization to cat allergen is associated with asthma in older men and predicts new-onset airway hyperresponsiveness. The Normative Aging Study.
Topics: Aged; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Case-Control Studies; Cats; Humans; Immunoglobulin E; Logistic Models; Longitudinal Studies; Male; Methacholine Chloride; Middle Aged | 1997 |
Improvement of bronchial hyperresponsiveness in asthmatic children treated for concomitant sinusitis.
Topics: Administration, Intranasal; Adolescent; Anti-Infective Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Prednisolone; Sinusitis; Sodium Chloride; Sulfamethoxazole; Trimethoprim | 1997 |
Prevalence of childhood asthma based on questionnaires and methacholine bronchial provocation test in Korea.
Topics: Adolescent; Adult; Allergens; Asthma; Child; Female; Humans; Hypersensitivity, Immediate; Korea; Male; Methacholine Chloride; Prevalence; Surveys and Questionnaires | 1997 |
The role of the methacholine inhalation challenge in adult patients presenting with chronic cough.
Topics: Administration, Inhalation; Adult; Asthma; Chronic Disease; Cough; Diagnosis, Differential; Female; Humans; Male; Methacholine Chloride; Middle Aged | 1997 |
Relationship between serum heat-stable neutrophil chemotactic activity during early airway reaction to allergen and the pattern of airway response (early versus late reactions) in asthmatic subjects.
Topics: Adolescent; Adult; Allergens; Asthma; Bronchial Provocation Tests; Chemotaxis, Leukocyte; Female; Forced Expiratory Volume; Hot Temperature; Humans; Male; Methacholine Chloride; Neutrophils; Time Factors | 1997 |
Eosinophils, mast cells, and basophils in induced sputum from patients with seasonal allergic rhinitis and perennial asthma: relationship to methacholine responsiveness.
Topics: Adult; Asthma; Basophils; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cell Count; Eosinophils; Female; Humans; Immunohistochemistry; Male; Mast Cells; Methacholine Chloride; Rhinitis, Allergic, Seasonal; Sputum | 1997 |
Asymptomatic airway hyperresponsiveness: a three-year follow-up.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Follow-Up Studies; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride; Middle Aged; Sex Characteristics; Surveys and Questionnaires; Time Factors | 1997 |
Occupational asthma caused by fish inhalation.
Topics: Adult; Animals; Antigens, Dermatophagoides; Asthma; Bronchial Provocation Tests; Environmental Monitoring; Female; Fishes; Glycoproteins; Humans; Immunoglobulin E; Male; Methacholine Chloride; Occupational Diseases; Peak Expiratory Flow Rate; Skin Tests | 1997 |
[Relation between asthma and atopy markers in children and young adults].
Topics: Adolescent; Adult; Age Factors; Asthma; Bronchial Hyperreactivity; Child; Data Interpretation, Statistical; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Male; Methacholine Chloride; Sensitivity and Specificity; Skin Tests | 1997 |
Citric acid-induced cough thresholds in normal subjects, patients with bronchial asthma, and smokers.
Topics: Administration, Inhalation; Adult; Aged; Asthma; Citric Acid; Cough; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Reference Values; Reflex; Smoking | 1997 |
Murine CTLA4-IgG treatment inhibits airway eosinophilia and hyperresponsiveness and attenuates IgE upregulation in a murine model of allergic asthma.
Topics: Abatacept; Administration, Inhalation; Animals; Antigens, CD; Antigens, Differentiation; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoconstrictor Agents; CTLA-4 Antigen; Cytokines; Disease Models, Animal; Eosinophilia; Immunoconjugates; Immunoglobulin E; Immunoglobulin G; Immunosuppressive Agents; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Protein Binding; Pulmonary Alveoli; Specific Pathogen-Free Organisms; Spleen; Up-Regulation | 1997 |
Occupational asthma in an isothiazolinone manufacturing plant.
Topics: Anti-Infective Agents; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Chemical Industry; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Occupational Diseases | 1997 |
Changes of soluble ICAM-1 levels in serum and bronchoalveolar lavage fluid from patients with atopic bronchial asthma after allergen challenge.
Topics: Adolescent; Adult; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Female; Forced Expiratory Volume; Humans; Intercellular Adhesion Molecule-1; Lung; Male; Methacholine Chloride; Middle Aged; Mites; Skin Tests; Up-Regulation | 1997 |
Aspirin-induced asthma as a risk factor for asthma mortality.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Respiratory Hypersensitivity; Risk Factors; Severity of Illness Index; Sex Factors | 1997 |
Is bronchial hyperresponsiveness more frequent in women than in men? A population-based study.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Confidence Intervals; Female; Forced Expiratory Volume; France; Humans; Hypersensitivity, Immediate; Logistic Models; Male; Methacholine Chloride; Odds Ratio; Risk Factors; Sex Characteristics; Sex Factors; Vital Capacity | 1997 |
Circulating levels of soluble interleukin-6 receptor in patients with bronchial asthma.
Topics: Adult; Aged; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Middle Aged; Receptors, Interleukin-6; Solubility | 1997 |
Induced sputum to assess airway inflammation: a study of reproducibility.
Topics: Adult; Allergens; Asthma; Blood Proteins; Bronchi; Bronchial Provocation Tests; Eosinophil Granule Proteins; Eosinophils; Epithelial Cells; Female; Forced Expiratory Volume; Humans; Inflammation; Leukocyte Count; Lymphocyte Count; Macrophages; Male; Methacholine Chloride; Middle Aged; Neutrophils; Reproducibility of Results; Rhinitis, Allergic, Seasonal; Ribonucleases; Skin Tests; Sputum; Vital Capacity | 1997 |
Prognostic factors for toluene diisocyanate-induced occupational asthma after removal from exposure.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Environmental Exposure; Female; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Longitudinal Studies; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Prognosis; Smoking; Steroids; Toluene 2,4-Diisocyanate | 1997 |
Effects of ozone on normal and potentially sensitive human subjects. Part I: Airway inflammation and responsiveness to ozone in normal and asthmatic subjects.
Topics: Adolescent; Adult; Airway Resistance; Asthma; Biopsy; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoscopy; Data Interpretation, Statistical; Female; Forced Expiratory Volume; Humans; Immunohistochemistry; Inflammation; Interleukin-8; Lung; Male; Methacholine Chloride; Middle Aged; Ozone; Physical Exertion; Therapeutic Irrigation; Time Factors; Vital Capacity | 1997 |
Effects of beta-agonists on dose-response curves.
Topics: Adrenergic beta-Agonists; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Drug Interactions; Humans; Methacholine Chloride; Randomized Controlled Trials as Topic; Respiratory Function Tests | 1997 |
Variation in nebulizer output and weight output from Mefar dosimeter: implications for multicentre studies.
Topics: Aerosols; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Calibration; Consumer Product Safety; Humans; Methacholine Chloride; Multicenter Studies as Topic; Nebulizers and Vaporizers | 1997 |
Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma.
Topics: Allergens; Animals; Antibodies, Monoclonal; Antigens, CD; Asthma; Bronchoconstrictor Agents; Cell Movement; Disease Models, Animal; Eosinophils; Female; Humans; Integrin alpha4; Leukocytes; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Hypersensitivity; Th2 Cells | 1997 |
Comparison of four different measures of bronchial responsiveness in asthmatic children.
Topics: Adolescent; Asthma; Asthma, Exercise-Induced; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Time Factors | 1997 |
Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS).
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Europe; European Union; Female; Health Surveys; Humans; Male; Methacholine Chloride; Nebulizers and Vaporizers; Prevalence; Random Allocation; Sampling Studies; Surveys and Questionnaires | 1997 |
Annual variability in methacholine responsiveness in nonasthmatic working adults.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Female; Humans; Longitudinal Studies; Male; Methacholine Chloride; Occupational Diseases; Occupational Exposure; Reference Values; Reproducibility of Results; Time Factors | 1997 |
Defining the asthma phenotype for the purpose of genetic analysis.
Topics: Adolescent; Adult; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Female; Forced Expiratory Volume; Humans; Immunoglobulin E; Male; Methacholine Chloride; Middle Aged; Pedigree; Skin Tests; Smoking; Spirometry; Surveys and Questionnaires | 1997 |
Relation between occupational asthma case history, bronchial methacholine challenge, and specific challenge test in patients with suspected occupational asthma.
Topics: Adult; Allied Health Personnel; Asthma; Beauty Culture; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Food Handling; Humans; Isocyanates; Methacholine Chloride; Occupational Diseases; Occupational Exposure; Sensitivity and Specificity; Time Factors | 1998 |
Changes in bone marrow inflammatory cell progenitors after inhaled allergen in asthmatic subjects.
Topics: Administration, Inhalation; Adult; Allergens; Asthma; Basophils; Bone Marrow Examination; Bronchial Provocation Tests; Bronchoconstrictor Agents; Eosinophils; Female; Forced Expiratory Volume; Hematopoietic Stem Cells; Humans; Male; Methacholine Chloride; Sputum; Time Factors | 1998 |
Personality profiles and breathlessness perception in outpatients with different gradings of asthma.
Topics: Adolescent; Adult; Asthma; Attitude to Health; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dyspnea; Female; Forced Expiratory Volume; Humans; Hypochondriasis; Methacholine Chloride; Middle Aged; MMPI; Personality; Severity of Illness Index | 1998 |
Occupational asthma specific to amoxicillin.
Topics: Administration, Inhalation; Administration, Oral; Amoxicillin; Asthma; Bronchial Provocation Tests; Female; Humans; Immunoglobulin E; Methacholine Chloride; Middle Aged; Occupational Diseases; Penicillins; Skin Tests | 1998 |
Variability of peak expiratory flow rate in allergic rhinitis and mild asthma: relationship to maximal airway narrowing.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Respiratory Function Tests; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 1998 |
Skin sensitivity to allergen does not accurately predict airway response to allergen.
Topics: Administration, Inhalation; Adult; Allergens; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dermatitis, Allergic Contact; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride; Middle Aged; Predictive Value of Tests; Respiratory Function Tests; Sensitivity and Specificity; Skin; Skin Tests | 1998 |
A case series of 71 patients referred to a hospital-based occupational and environmental medicine clinic for occupational asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Cross-Sectional Studies; Female; Humans; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Peak Expiratory Flow Rate; Spirometry | 1998 |
A seven-year follow-up study of lung function and methacholine responsiveness in sensitized and non-sensitized workers handling laboratory animals.
Topics: Adult; Airway Resistance; Animals; Animals, Laboratory; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dermatitis, Contact; Female; Follow-Up Studies; Health Status; Humans; Male; Methacholine Chloride; Middle Aged; Occupational Exposure; Respiratory Function Tests; Rhinitis; Surveys and Questionnaires | 1998 |
Multiple regression analysis of airway responsiveness in adult asthmatic patients.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Humans; Immunoglobulin E; Logistic Models; Male; Methacholine Chloride; Middle Aged; Predictive Value of Tests; Regression Analysis; Retrospective Studies; Spirometry | 1998 |
A rapid dosimetric methacholine challenge in asthma diagnostics: a clinical study of 230 patients with dyspnoea, wheezing or a cough of unknown cause.
Topics: Adult; Asthma; Bayes Theorem; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Predictive Value of Tests; Regression Analysis; Sensitivity and Specificity; Spirometry | 1998 |
Chronic cough resembles asthma with IL-5 and granulocyte-macrophage colony-stimulating factor gene expression in bronchoalveolar cells.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Chronic Disease; Cough; DNA Primers; DNA, Complementary; Female; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Inflammation; Interleukin-5; Male; Methacholine Chloride; Middle Aged; Polymerase Chain Reaction; RNA, Messenger; Skin Tests; Spirometry | 1998 |
Environmental and clinical study of latex allergy in a textile factory.
Topics: Air Pollution, Indoor; Allergens; Animals; Asthma; Bronchial Provocation Tests; Humans; Immunoglobulin E; Latex; Methacholine Chloride; Mites; Occupational Diseases; Radioallergosorbent Test; Respiratory Hypersensitivity; Rhinitis, Allergic, Perennial; Skin Tests; Talc | 1998 |
The utility of methacholine airway responsiveness measurements in evaluating anti-asthma drugs.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Albuterol; Allergens; Anti-Asthmatic Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Drug Monitoring; Forced Expiratory Volume; Humans; Methacholine Chloride; Reproducibility of Results | 1998 |
CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma.
Topics: Abatacept; Airway Resistance; Animals; Antibodies, Helminth; Antigens, CD; Antigens, Differentiation; Antigens, Helminth; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; CTLA-4 Antigen; Culture Media, Conditioned; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophilia; Female; Humans; Immunoconjugates; Immunoglobulin E; Immunosuppressive Agents; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Recombinant Fusion Proteins; Schistosoma mansoni; T-Lymphocytes; Th1 Cells; Th2 Cells | 1998 |
Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice.
Topics: Administration, Cutaneous; Aerosols; Allergens; Animals; Antibody Specificity; Asthma; Base Sequence; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Dermatitis, Atopic; Disease Models, Animal; DNA Primers; Eosinophilia; Female; Immunization; Immunoglobulin E; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; RNA, Messenger; Skin | 1998 |
Diurnal variation of peak expiratory flow in children with cough variant asthma.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Child; Circadian Rhythm; Cough; Female; Humans; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Respiratory Sounds | 1998 |
Acute bronchodilatory effect of salmeterol on methacholine-induced bronchoconstriction in childhood asthma.
Topics: Adolescent; Albuterol; Asthma; Bronchoconstriction; Bronchodilator Agents; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Salmeterol Xinafoate | 1998 |
Bronchial reactivity to cigarette smoke in smokers: repeatability, relationship to methacholine reactivity, smoking and atopy.
Topics: Asthma; Bronchial Provocation Tests; Bronchitis; Bronchoconstriction; Bronchoconstrictor Agents; Cross-Sectional Studies; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Linear Models; Male; Methacholine Chloride; Middle Aged; Reproducibility of Results; Respiratory Function Tests; Smoke; Smoking | 1998 |
A 3-year follow-up of asthmatic patients participating in a 10-week rehabilitation program with emphasis on physical training.
Topics: Adult; Ambulatory Care; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Exercise Test; Exercise Therapy; Female; Follow-Up Studies; Heart Function Tests; Humans; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Physical Education and Training; Respiratory Function Tests; Surveys and Questionnaires | 1998 |
Airway eosinophilic inflammation and bronchial hyperresponsiveness after allergen inhalation challenge in asthma.
Topics: Adolescent; Adult; Allergens; Asthma; Blood Proteins; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Bronchoscopy; Case-Control Studies; Eosinophil Granule Proteins; Eosinophils; Female; Humans; Inflammation Mediators; Male; Methacholine Chloride; Pulmonary Eosinophilia; Ribonucleases | 1998 |
Repeated aerosol exposure to small doses of allergen. A model for chronic allergic asthma.
Topics: Adolescent; Adult; Aerosols; Allergens; Animals; Antigens, Dermatophagoides; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Chronic Disease; Environmental Exposure; Female; Forced Expiratory Volume; Glycoproteins; Humans; Male; Methacholine Chloride; Middle Aged; Mites | 1998 |
[Cough variant asthma among patients with chronic persistent cough and its clinical outcome].
Topics: Asthma; Bronchial Hyperreactivity; Chronic Disease; Cough; Female; Humans; Male; Methacholine Chloride; Middle Aged | 1998 |
Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma.
Topics: Adult; Asthma; Biomarkers; Blood Proteins; Breath Tests; Bronchial Provocation Tests; Cross-Sectional Studies; Eosinophil Granule Proteins; Eosinophils; Female; Humans; Leukocyte Count; Luminescent Measurements; Lung; Male; Methacholine Chloride; Nitric Oxide; Predictive Value of Tests; Respiratory Function Tests; Ribonucleases; Sputum; Statistics, Nonparametric | 1998 |
Investigating the asthma phenotype.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Genetic Linkage; Humans; Immunoglobulin E; Methacholine Chloride; Phenotype; Radioallergosorbent Test | 1998 |
Mite-antigen avoidance can reduce bronchial epithelial shedding in allergic asthmatic children.
Topics: Adolescent; Allergens; Altitude; Animals; Antigens; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Dust; Endopeptidases; Eosinophils; Epithelial Cells; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Mites; Sputum | 1998 |
Airway hyperresponsiveness in asthma. Not just a problem of smooth muscle relaxation with inspiration.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Forced Expiratory Volume; Humans; Methacholine Chloride; Muscle Relaxation; Muscle, Smooth; Respiratory Function Tests | 1998 |
Bronchial and cutaneous responses in atopic dermatitis patients after allergen inhalation challenge.
Topics: Adolescent; Adult; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dermatitis, Atopic; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests | 1997 |
Non-specific airway hyperresponsiveness in mono-sensitive Sicilian patients with allergic rhinitis. Its relationship to total serum IgE levels and blood eosinophils during and out of the pollen season.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Eosinophils; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Pollen; Respiratory Function Tests; Rhinitis, Allergic, Seasonal; Seasons; Sicily; Skin Tests; Statistics, Nonparametric | 1997 |
Bronchial reactivity and intracellular magnesium: a possible mechanism for the bronchodilating effects of magnesium in asthma.
Topics: Adult; Analysis of Variance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Erythrocytes; Female; Humans; Hypersensitivity, Immediate; Intracellular Fluid; Magnesium; Male; Methacholine Chloride; Pollen | 1998 |
Airway hyperreactivity: assessment with helical thin-section CT.
Topics: Adolescent; Adult; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Functional Residual Capacity; Humans; Male; Methacholine Chloride; Residual Volume; Spirometry; Tomography, X-Ray Computed | 1998 |
Clinical differences among women with and without self-reported perimenstrual asthma.
Topics: Adolescent; Adult; Asthma; Female; Forced Expiratory Volume; Humans; Menstruation; Methacholine Chloride; Middle Aged; Prospective Studies | 1998 |
Modulation of airway hyperresponsiveness and eosinophilia by selective histamine and 5-HT receptor antagonists in a mouse model of allergic asthma.
Topics: Airway Resistance; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Eosinophilia; Histamine Antagonists; Immunoglobulin E; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Serotonin Antagonists; Succinimides | 1998 |
Worsening of hypoxemia with nitric oxide inhalation during bronchospasm in humans.
Topics: Administration, Inhalation; Adult; Asthma; Dose-Response Relationship, Drug; Female; Humans; Hypoxia; Lung Diseases, Obstructive; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Pulmonary Gas Exchange | 1998 |
Mechanism of methacholine dose-response plateaus in normal subjects.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Reference Values; Respiratory Mechanics | 1998 |
High prevalence of bronchial hyperresponsiveness and asthma in ice hockey players.
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Sectional Studies; Dose-Response Relationship, Drug; Forced Expiratory Volume; Hockey; Humans; Incidence; Male; Methacholine Chloride; Risk; Switzerland | 1998 |
Neurokinin A is the predominant tachykinin in human bronchoalveolar lavage fluid in normal and asthmatic subjects.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Calcitonin Gene-Related Peptide; Chromatography, High Pressure Liquid; Female; Humans; Male; Methacholine Chloride; Neurokinin A; Radioimmunoassay; Statistics, Nonparametric; Substance P | 1998 |
Activation of B-lymphocytes during pollen season. Effect of immunotherapy.
Topics: Adult; Allergens; Antigens, CD19; Asthma; B-Lymphocytes; CD40 Antigens; Cell Count; Double-Blind Method; Female; Flow Cytometry; HLA-DR Antigens; Humans; Hypersensitivity; Immunotherapy; Lymphocyte Activation; Male; Methacholine Chloride; Middle Aged; Pollen; Receptors, IgE; Seasons; Trees | 1998 |
Follow-up of occupational asthma after removal from or diminution of exposure to the responsible agent: relevance of the length of the interval from cessation of exposure.
Topics: Adult; Air Pollutants, Occupational; Asthma; Bronchial Provocation Tests; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Occupational Diseases; Occupational Exposure; Retrospective Studies; Severity of Illness Index; Spirometry; Surveys and Questionnaires; Time Factors | 1998 |
Bronchial responsiveness and angiotensin-converting enzyme gene polymorphism in sarcoidosis patients.
Topics: Adult; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Cough; DNA; DNA Primers; Female; Genotype; Humans; Male; Methacholine Chloride; Middle Aged; Peptidyl-Dipeptidase A; Polymerase Chain Reaction; Polymorphism, Genetic; Sarcoidosis, Pulmonary | 1998 |
Exhaled nitric oxide is higher both at day and night in subjects with nocturnal asthma.
Topics: Adolescent; Adult; Airway Obstruction; Asthma; Bronchial Provocation Tests; Bronchitis; Bronchoconstrictor Agents; Circadian Rhythm; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Peak Expiratory Flow Rate; Regression Analysis; Respiration | 1998 |
Allergen immunotherapy inhibits airway eosinophilia and hyperresponsiveness associated with decreased IL-4 production by lymphocytes in a murine model of allergic asthma.
Topics: Alveolitis, Extrinsic Allergic; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Desensitization, Immunologic; Disease Models, Animal; Immunoglobulin E; Immunoglobulin G; Interferon-gamma; Interleukin-4; Lymph Nodes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Pulmonary Eosinophilia; Specific Pathogen-Free Organisms; T-Lymphocytes | 1998 |
Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Eosinophils; Female; Forced Expiratory Volume; Free Radical Scavengers; Humans; Hydrogen Peroxide; Male; Methacholine Chloride; Nitric Oxide; Oxidants; Oxidative Stress; Respiration; Sputum | 1998 |
Impaired perception of dyspnea in patients with severe asthma. Relation to sputum eosinophils.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Dyspnea; Eosinophilia; Eosinophils; Female; Forced Expiratory Volume; Humans; Leukocyte Count; Male; Methacholine Chloride; Middle Aged; Perception; Recurrence; Regression Analysis; Risk Factors; Saline Solution, Hypertonic; Sputum; Status Asthmaticus | 1998 |
Inhalation anaesthetics produce asynchronous reversal of ventilation inhomogeneity and increased lung resistance in a canine model of bronchial asthma.
Topics: Airway Resistance; Anesthetics, Inhalation; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Methacholine Chloride; Respiratory Mechanics | 1998 |
Differential effects of endogenous and exogenous interferon-gamma on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma.
Topics: Administration, Inhalation; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II; Hypersensitivity; Immunoglobulin E; Injections, Intraperitoneal; Interferon-gamma; Leukocytes; Lymph Nodes; Macrophages, Alveolar; Methacholine Chloride; Mice; Mice, Knockout; Ovalbumin; Spleen; T-Lymphocytes | 1998 |
In vivo function of an interleukin 2 receptor beta chain (IL-2Rbeta)/IL-4Ralpha cytokine receptor chimera potentiates allergic airway disease.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Flow Cytometry; Humans; Hypersensitivity; Immunization; Immunoglobulin E; Immunoglobulin G; Methacholine Chloride; Mice; Mice, Transgenic; Ovalbumin; Receptors, Interleukin-2; Receptors, Interleukin-4; Recombinant Fusion Proteins; Signal Transduction; STAT6 Transcription Factor; T-Lymphocytes; Th2 Cells; Trans-Activators | 1998 |
Prostaglandins E2 and F2alpha reduce exhaled nitric oxide in normal and asthmatic subjects irrespective of airway caliber changes.
Topics: Administration, Inhalation; Adult; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Dinoprost; Dinoprostone; Enzyme Inhibitors; Female; Forced Expiratory Volume; Humans; Luminescent Measurements; Male; Methacholine Chloride; Nitric Oxide; Nitric Oxide Synthase | 1998 |
Benefits of high-dose i.v. immunoglobulin in patients with severe steroid-dependent asthma.
Topics: Administration, Oral; Adolescent; Adult; Asthma; Bone Density; Bronchial Provocation Tests; Child; Female; Forced Expiratory Volume; Glucocorticoids; Humans; Immunoglobulins, Intravenous; Infusions, Intravenous; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Vital Capacity | 1998 |
The myth of maximal airway responsiveness in vivo.
Topics: Aerosols; Airway Resistance; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Dogs; Dose-Response Relationship, Drug; Humans; Methacholine Chloride; Respiratory System; Tomography, X-Ray Computed | 1998 |
Effects of thromboxane A2 antagonist on airway hyperresponsiveness, exhaled nitric oxide, and induced sputum eosinophils in asthmatics.
Topics: Anti-Asthmatic Agents; Asthma; Benzoquinones; Bronchial Hyperreactivity; Eosinophils; Female; Forced Expiratory Volume; Heptanoic Acids; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Prostaglandin Antagonists; Respiration; Sputum; Thromboxane A2 | 1998 |
Both CD80 and CD86 co-stimulatory molecules regulate allergic pulmonary inflammation.
Topics: Animals; Antigens, CD; Asthma; B7-1 Antigen; B7-2 Antigen; Bronchial Hyperreactivity; Cytokines; Disease Models, Animal; Eosinophilia; Lung; Lymphocyte Activation; Male; Membrane Glycoproteins; Methacholine Chloride; Mice; Mice, Inbred BALB C; Respiratory Hypersensitivity; T-Lymphocytes; Th2 Cells | 1998 |
Effects of endogenous superoxide anion and nitric oxide on cholinergic constriction of normal and hyperreactive guinea pig airways.
Topics: Administration, Inhalation; Aerosols; Allergens; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bronchodilator Agents; Cholinergic Fibers; Disease Models, Animal; Enzyme Inhibitors; Free Radical Scavengers; Guinea Pigs; Immunization; Methacholine Chloride; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ovalbumin; Parasympathomimetics; Superoxide Dismutase; Superoxides; Trachea | 1998 |
Association of persistent bronchial hyperresponsiveness with beta2-adrenoceptor (ADRB2) haplotypes. A population study.
Topics: Adolescent; Adult; Allergens; Amino Acid Sequence; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Confounding Factors, Epidemiologic; Environment; Genetic Predisposition to Disease; Genetic Variation; Glutamine; Glycine; Haplotypes; Humans; Immunoglobulin E; Male; Methacholine Chloride; Polymorphism, Genetic; Population Surveillance; Receptors, Adrenergic, beta-2; Risk Factors | 1998 |
Perception of respiratory symptoms after methacholine-induced bronchoconstriction in a general population.
Topics: Adult; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Dyspnea; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Respiratory Sounds; Sensation; Surveys and Questionnaires | 1998 |
Change in airway responsiveness among apprentices exposed to metalworking fluids.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Environmental Exposure; Female; Forced Expiratory Volume; Humans; Longitudinal Studies; Male; Metallurgy; Methacholine Chloride; Occupational Diseases; Prospective Studies; Reference Values; Time Factors; Vital Capacity | 1999 |
Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Cytokines; Disease Models, Animal; Eosinophils; Histocytochemistry; Hypersensitivity; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, SCID; Mice, Transgenic; Ovalbumin; Th1 Cells; Th2 Cells | 1999 |
Asthma-like symptoms, atopy, and bronchial responsiveness in furniture workers.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Cross-Sectional Studies; Female; Genetic Predisposition to Disease; Humans; Interior Design and Furnishings; Italy; Male; Methacholine Chloride; Middle Aged; Occupational Exposure; Risk Factors; Smoking; Spirometry; Surveys and Questionnaires | 1998 |
Increase in non-specific bronchial hyperresponsiveness without specific response to isocyanate in isocyanate-induced asthma: a pilot study.
Topics: Adult; Air Pollutants, Occupational; Analysis of Variance; Asthma; Bronchial Hyperreactivity; Female; Humans; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Parasympathomimetics; Pilot Projects; Predictive Value of Tests; Statistics, Nonparametric; Toluene 2,4-Diisocyanate | 1998 |
Vbeta8+ T lymphocytes are essential in the regulation of airway hyperresponsiveness and bronchoalveolar eosinophilia but not in allergen-specific IgE in a murine model of allergic asthma.
Topics: Animals; Antibody Specificity; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Enzyme-Linked Immunosorbent Assay; Eosinophilia; Immunoglobulin E; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Receptors, Antigen, T-Cell, alpha-beta; Spleen; T-Lymphocytes | 1998 |
Occupational asthma and IgE sensitization to cellulase in a textile industry worker.
Topics: Adult; Antibodies, Fungal; Antibody Specificity; Asthma; Bronchial Provocation Tests; Cellulase; Fungal Proteins; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Immunoglobulin G; Male; Methacholine Chloride; Occupational Diseases; Skin Tests; Textile Industry | 1999 |
New occupational allergen in citrus farmers: citrus red mite (Panonychus citri).
Topics: Adult; Aged; Agricultural Workers' Diseases; Allergens; Animals; Antibody Specificity; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Citrus; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Middle Aged; Mites; Respiratory Function Tests; Rhinitis, Allergic, Perennial; Skin Tests | 1999 |
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production.
Topics: Airway Resistance; Animals; Asthma; Bronchi; Bronchoconstrictor Agents; Chemokine CCL11; Chemokines, CC; Collagen; Cytokines; Epithelial Cells; Histocytochemistry; Interleukin-13; Lung; Methacholine Chloride; Mice; Mice, Transgenic; Mucus; Pneumonia; Pulmonary Fibrosis; Respiratory System | 1999 |
Genetically transmitted cholinergic hyperresponsiveness predisposes to experimental asthma.
Topics: Airway Obstruction; Animals; Asthma; Autonomic Nervous System Diseases; Bronchoalveolar Lavage Fluid; Cell Count; Female; Lung; Male; Methacholine Chloride; Ovalbumin; Parasympathetic Nervous System; Parasympathomimetics; Rats; Rats, Sprague-Dawley; Respiratory Mechanics | 1998 |
Vascularity in asthmatic airways: relation to inhaled steroid dose.
Topics: Administration, Inhalation; Adult; Asthma; Basement Membrane; Beclomethasone; Bronchi; Bronchoconstrictor Agents; Bronchoscopy; Case-Control Studies; Collagen; Drug Administration Schedule; Female; Glucocorticoids; Humans; Hypersensitivity; Immunohistochemistry; Male; Methacholine Chloride; Middle Aged; Neovascularization, Pathologic | 1999 |
An in vivo model of beta-adrenoceptor desensitization.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Albuterol; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Guinea Pigs; Interleukin-1; Intubation, Intratracheal; Isoproterenol; Male; Methacholine Chloride; Respiratory Hypersensitivity | 1998 |
Selective airway responsiveness in asthma.
Topics: Albuterol; Animals; Asthma; Bradykinin; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Bronchodilator Agents; Humans; Leukotriene C4; Methacholine Chloride | 1999 |
Deposition patterns of nebulized drugs: is the pattern important?
Topics: Aerosols; Asthma; Cyclosporins; Cystic Fibrosis; Dose-Response Relationship, Drug; Gentamicins; Humans; Lung; Lung Transplantation; Methacholine Chloride; Pentamidine; Pneumonia, Pneumocystis | 1994 |
Do respiratory symptoms predict chronic airflow obstruction and bronchial hyperresponsiveness in older adults?
Topics: Age Factors; Aged; Aged, 80 and over; Airway Obstruction; Asthma; Bronchial Hyperreactivity; Bronchitis; Bronchoconstrictor Agents; Chronic Disease; Cough; Dyspnea; Female; Forced Expiratory Volume; Forecasting; Humans; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Respiration; Respiratory Sounds; Smoking; Spirometry; Sputum; Surveys and Questionnaires; Vital Capacity | 1999 |
An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen.
Topics: Aerosols; Allergens; Animals; Asthma; Bronchoconstrictor Agents; Disease Models, Animal; Eosinophils; Epithelium; Female; Immunoglobulin E; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Specific Pathogen-Free Organisms; Trachea | 1998 |
Repeatability of lung function tests during methacholine challenge in wheezy infants.
Topics: Asthma; Bronchoconstrictor Agents; Child, Preschool; Evaluation Studies as Topic; Female; Humans; Infant; Male; Methacholine Chloride; Oxygen; Partial Pressure; Recurrence; Reproducibility of Results; Respiratory Function Tests; Respiratory Sounds | 1998 |
Eosinophils in the bronchial mucosa in relation to methacholine dose-response curves in atopic asthma.
Topics: Adult; Asthma; Biopsy; Bronchi; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Eosinophils; Female; Forced Expiratory Volume; Humans; Immunohistochemistry; Male; Methacholine Chloride; Middle Aged; Mucous Membrane; Regression Analysis | 1999 |
Increased perception of airway narrowing in patients with mild asthma.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cough; Dyspnea; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Perception; Respiratory Sounds; Smoking | 1998 |
Airway cough sensitivity to inhaled capsaicin and bronchial responsiveness to methacholine in asthmatic and bronchitic subjects.
Topics: Administration, Inhalation; Analysis of Variance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Bronchoconstrictor Agents; Capsaicin; Chronic Disease; Cough; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers; Regression Analysis; Vital Capacity | 1998 |
Airway inflammation, exhaled nitric oxide, and severity of asthma in patients with western red cedar asthma.
Topics: Adult; Asthma; Bronchoconstrictor Agents; Cell Count; Eosinophils; Female; Forced Expiratory Volume; Humans; Inflammation; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Respiration; Respiratory System; Severity of Illness Index; Sputum; Trees | 1999 |
Increased muscarinic receptor blockade by atropine in tracheal chains of ovalbumin-sensitized guinea pigs.
Topics: Animals; Asthma; Atropine; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Guinea Pigs; Male; Methacholine Chloride; Muscarinic Antagonists; Ovalbumin; Receptors, Muscarinic; Trachea | 1999 |
Absence of diurnal variability of airway reactivity and hypoxic ventilatory drive in adolescents with stable asthma.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Circadian Rhythm; Female; Forced Expiratory Volume; Humans; Hypoxia; Male; Methacholine Chloride; Severity of Illness Index; Vagus Nerve | 1999 |
Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Calcium; Disease Models, Animal; Gene Targeting; Histocytochemistry; Humans; Isoenzymes; Lung; Methacholine Chloride; Mice; Mice, Knockout; Nitric Oxide Synthase; Ovalbumin; Plethysmography; Pneumonia | 1999 |
Dissociation of airway hyperresponsiveness from immunoglobulin E and airway eosinophilia in a murine model of allergic asthma.
Topics: Animals; Asthma; Bronchoconstrictor Agents; Cell Movement; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophilia; Humans; Immunoglobulin E; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ovalbumin; Respiratory Hypersensitivity | 1999 |
The respiratory burst activity of activated eosinophils in atopic asthmatics.
Topics: Administration, Inhalation; Antibodies, Monoclonal; Asthma; Blood Proteins; Bronchial Hyperreactivity; Bronchial Provocation Tests; Eosinophil Granule Proteins; Eosinophils; Flow Cytometry; Fluoresceins; Fluorescent Antibody Technique; Humans; Immunoglobulin E; Leukocyte Count; Methacholine Chloride; Respiratory Burst; Respiratory Function Tests; Ribonucleases | 1999 |
Effect of methacholine challenge on cellular composition of sputum induction.
Topics: Adolescent; Adult; Asthma; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Sputum; Vital Capacity | 1999 |
Occupational asthma in Europe and other industrialised areas: a population-based study. European Community Respiratory Health Survey Study Group.
Topics: Adult; Asthma; Bronchoconstrictor Agents; Confidence Intervals; Europe; Female; Humans; Male; Methacholine Chloride; Occupational Diseases; Occupations; Odds Ratio; Prevalence; Risk Factors; Spirometry; Surveys and Questionnaires | 1999 |
Shifts in lung lymphocyte profiles correlate with the sequential development of acute allergic and chronic tolerant stages in a murine asthma model.
Topics: Airway Resistance; Animals; Asthma; B-Lymphocytes; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fluorescent Antibody Technique; Hypersensitivity; Immunoglobulin E; Lymphocytes; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Ovalbumin; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes; Time Factors | 1999 |
Exhaled nitric oxide, sensitization, and exposure to allergens in patients with asthma who are not taking inhaled steroids.
Topics: Adolescent; Adult; Airway Resistance; Allergens; Animals; Asthma; Breath Tests; Bronchial Provocation Tests; Cats; Dogs; Female; Humans; Immunoglobulin E; Intradermal Tests; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Respiratory Hypersensitivity; Systemic Inflammatory Response Syndrome | 1999 |
Markers of inflammation and bronchial reactivity in children with asthma, exposed to animal dander in school dust.
Topics: Adolescent; Allergens; Animals; Antigens, Plant; Asthma; Biomarkers; Blood Proteins; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cats; Child; Dogs; Dust; Eosinophil Peroxidase; Eosinophil-Derived Neurotoxin; Eosinophils; Female; Glycoproteins; Humans; Leukotriene E4; Male; Methacholine Chloride; Nasal Lavage Fluid; Peroxidase; Peroxidases; Ribonucleases; Sputum | 1999 |
Wheezing in school children is not always asthma.
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Dose-Response Relationship, Drug; Female; Humans; Hypersensitivity, Immediate; Lung Volume Measurements; Male; Methacholine Chloride; Random Allocation; Respiratory Sounds; Skin Tests | 1999 |
Comparison of two methacholine challenge methods using Spira-2 or Mefar dosimeter.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Evaluation Studies as Topic; Female; Forced Expiratory Volume; Humans; Linear Models; Male; Methacholine Chloride; Nebulizers and Vaporizers | 1999 |
Simple forced oscillatory technique and spirometry in assessment of bronchial responsiveness in non-asthmatic and asthmatic subjects.
Topics: Adolescent; Adult; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Female; Forced Expiratory Flow Rates; High-Frequency Ventilation; Humans; Male; Methacholine Chloride; Predictive Value of Tests; Sensitivity and Specificity; Spirometry | 1999 |
Citrus red mite (Panonychus citri) is the most common sensitizing allergen of asthma and rhinitis in citrus farmers.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Agricultural Workers' Diseases; Animals; Asthma; Bronchial Provocation Tests; Citrus; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Middle Aged; Mites; Rhinitis, Allergic, Perennial; Skin Tests; Surveys and Questionnaires | 1999 |
Methacholine-induced fall in forced vital capacity as a marker of asthma severity.
Topics: Adrenal Cortex Hormones; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Sectional Studies; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Respiratory Therapy; Retrospective Studies; Severity of Illness Index; Vital Capacity | 1999 |
[The diagnostic role of the methacholine inhalation challenge in adult patients with chronic persistent cough].
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Chronic Disease; Cough; Diagnosis, Differential; Female; Humans; Infections; Male; Methacholine Chloride | 1999 |
Methacholine challenge and sputum induction.
Topics: Asthma; Blood Proteins; Bronchoconstrictor Agents; Eosinophil Granule Proteins; Humans; Methacholine Chloride; Ribonucleases; Sputum | 1999 |
Difference in airway reactivity in children with atopic vs nonatopic asthma.
Topics: Adolescent; Adrenergic beta-Agonists; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Child; Female; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride | 1999 |
[Clinical evaluation and significance of measurement of airway hyperresponsiveness in COPD].
Topics: Adult; Aged; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Contraindications; Female; Forced Expiratory Volume; Humans; Lung Diseases, Obstructive; Male; Methacholine Chloride; Middle Aged; Prognosis | 1999 |
Bronchial reactivity to inhaled methacholine in infants with asthma and age-matched controls.
Topics: Age Factors; Asthma; Blood Gas Monitoring, Transcutaneous; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child, Preschool; Female; Humans; Infant; Male; Methacholine Chloride; Reference Values | 1999 |
Allergen-induced increase in airway responsiveness, airway eosinophilia, and bone-marrow eosinophil progenitors in mice.
Topics: Allergens; Animals; Asthma; Bone Marrow; Bronchial Hyperreactivity; Colony-Forming Units Assay; Disease Models, Animal; Dogs; Eosinophilia; Eosinophils; Hematopoiesis; Hematopoietic Stem Cells; Humans; Interleukin-5; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin | 1999 |
Asthma in tunnel workers exposed to synthetic resins.
Topics: Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Sectional Studies; Humans; Methacholine Chloride; Middle Aged; Occupational Diseases; Occupational Exposure; Resins, Synthetic; Respiratory Function Tests | 1999 |
Critical role of CD23 in allergen-induced bronchoconstriction in a murine model of allergic asthma.
Topics: Allergens; Animals; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Eosinophils; Female; Immunoglobulin E; Macrophages, Alveolar; Methacholine Chloride; Mice; Mice, Congenic; Mice, Inbred BALB C; Mice, Inbred C57BL; Ovalbumin; Receptors, Fc; Receptors, IgE; Time Factors | 1999 |
Functional screening of an asthma QTL in YAC transgenic mice.
Topics: Animals; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Chromosomes, Artificial, Yeast; Flow Cytometry; Gene Expression; Genetic Testing; Humans; Immunoglobulin E; Interleukin-13; Interleukin-4; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phenotype; Quantitative Trait, Heritable; RNA; T-Lymphocytes; Th2 Cells | 1999 |
Dynamic hyperinflation and flow limitation during methacholine-induced bronchoconstriction in asthma.
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstriction; Dose-Response Relationship, Drug; Expiratory Reserve Volume; Female; Forced Expiratory Volume; Humans; Inspiratory Capacity; Lung Volume Measurements; Male; Methacholine Chloride; Peak Expiratory Flow Rate; Plethysmography, Whole Body; Spirometry | 1999 |
Development of wheezing in patients with cough variant asthma during an increase in airway responsiveness.
Topics: Adolescent; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Cough; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Prospective Studies; Respiratory Sounds | 1999 |
Neutrophil activation following TDI bronchial challenges to the airway secretion from subjects with TDI-induced asthma.
Topics: Adult; Asthma; Bronchi; Bronchoconstrictor Agents; Female; Humans; Interleukin-8; Male; Methacholine Chloride; Middle Aged; Neutrophil Activation; Occupational Diseases; Peroxidase; Sputum; Toluene 2,4-Diisocyanate | 1999 |
Amalgam allergy associated with exacerbation of aspirin-intolerant asthma.
Topics: Adult; Aspirin; Asthma; Bronchial Hyperreactivity; Dental Amalgam; Dipyrone; Female; Humans; Methacholine Chloride; Skin Tests | 1999 |
Beta2-adrenergic receptor polymorphisms affect airway responsiveness to salbutamol in asthmatics.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Dose-Response Relationship, Drug; Forced Expiratory Volume; Genotype; Homozygote; Humans; Methacholine Chloride; Middle Aged; Polymorphism, Genetic; Receptors, Adrenergic, beta-2 | 1999 |
Effect of different sensitizing doses of antigen in a murine model of atopic asthma.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cells, Cultured; Dose-Response Relationship, Drug; Eosinophils; Female; Hypersensitivity, Immediate; Immunoglobulin E; Immunoglobulin G; Interferon-gamma; Interleukins; Leukocytes, Mononuclear; Lung; Lymphocyte Activation; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin | 1999 |
Sensitivity to the house dust mite and airway hyperresponsiveness in a young adult population.
Topics: Adult; Allergens; Animals; Antigens, Dermatophagoides; Aspergillus fumigatus; Asthma; Blood Proteins; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cats; Dogs; Dust; Eosinophil Granule Proteins; Eosinophilia; Female; Forced Expiratory Volume; Glycoproteins; Hair; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Japan; Male; Methacholine Chloride; Mites; Pollen; Radioallergosorbent Test; Ribonucleases; Spirometry | 1999 |
Exhaled nitric oxide and its relationship to airway responsiveness and atopy in asthma. BHR-Study Group.
Topics: Adolescent; Adult; Asthma; Bronchoconstrictor Agents; Female; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Peak Expiratory Flow Rate | 1999 |
Cut-off points defining normal and asthmatic bronchial reactivity to exercise and inhalation challenges in children and young adults.
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Child; Child, Preschool; Diagnosis, Differential; Exercise; Forced Expiratory Flow Rates; Histamine; Humans; Methacholine Chloride; Retrospective Studies; ROC Curve; Severity of Illness Index | 1999 |
Vernal keratoconjunctivitis in a Stockholm ophthalmic centre--epidemiological, functional, and immunologic investigations.
Topics: Adolescent; Africa; Asia; Asthma; Biomarkers; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Child; Child, Preschool; Chlamydia; Ethnicity; Female; Humans; Hypersensitivity; Keratoconjunctivitis; Male; Methacholine Chloride; Retrospective Studies; Seasons; Sweden | 1999 |
Relationship of cellular transmigration and airway response after allergen challenge.
Topics: Allergens; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoscopy; Cell Count; Cell Movement; Eosinophils; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Leukocyte Count; Male; Methacholine Chloride; Neutrophils; Pulmonary Alveoli; Skin Tests | 1999 |
Role of L-arginine in the deficiency of nitric oxide and airway hyperreactivity after the allergen-induced early asthmatic reaction in guinea-pigs.
Topics: Allergens; Animals; Arginine; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Methacholine Chloride; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ovalbumin; Trachea | 1999 |
Hypoxemia in young asthmatics with mild airway obstruction by methacholine challenge.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Humans; Hypoxia; Male; Methacholine Chloride; Military Personnel | 1999 |
Non-invasive evaluation of lower airway inflammation in hyper-responsive elite cross-country skiers and asthmatics.
Topics: Adenosine Monophosphate; Adolescent; Adult; Analysis of Variance; Asthma; Biomarkers; Breath Tests; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Case-Control Studies; Female; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Skiing; Statistics, Nonparametric | 1999 |
Effect of interleukin-16-blocking peptide on parameters of allergic asthma in a murine model.
Topics: Administration, Intranasal; Airway Resistance; Amino Acid Sequence; Animals; Anti-Asthmatic Agents; Antibodies, Blocking; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Separation; Chemotaxis, Leukocyte; Eosinophils; In Vitro Techniques; Interleukin-16; Methacholine Chloride; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Muscarinic Agonists; Oligopeptides; Ovalbumin; Peptide Fragments | 1999 |
Asthma-related work disability in Sweden. The impact of workplace exposures.
Topics: Adult; Asthma; Bronchial Provocation Tests; Disability Evaluation; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Linear Models; Male; Methacholine Chloride; Occupational Diseases; Occupational Exposure; Risk Factors; Skin Tests; Surveys and Questionnaires; Sweden | 1999 |
In vivo airway eosinophil accumulation does not enhance antigen- or propranolol-induced bronchoconstriction in guinea pigs.
Topics: Administration, Inhalation; Administration, Intranasal; Animals; Antigens; Asthma; Bronchoconstriction; Bronchoconstrictor Agents; Disease Models, Animal; Eosinophils; Guinea Pigs; Lipids; Male; Methacholine Chloride; Mice; Polymyxin B; Propranolol; Respiratory System | 1999 |
Airway inflammation and altered alveolar macrophage phenotype pattern after repeated low-dose allergen exposure of atopic asthmatic subjects.
Topics: Adult; Allergens; Antibodies, Monoclonal; Asthma; Blood Proteins; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Eosinophil Granule Proteins; Eosinophils; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Inflammation; Macrophages, Alveolar; Male; Methacholine Chloride; Poaceae; Pollen; Ribonucleases; Trees | 1999 |
Value of immunoglobulin E density in predicting nasal and bronchial response to inhaled allergens in rhinitic and asthmatic subjects with multiple sensitizations.
Topics: Administration, Inhalation; Adolescent; Adult; Allergens; Asthma; Bronchi; Bronchial Provocation Tests; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Middle Aged; Nose; Predictive Value of Tests; Radioallergosorbent Test; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 1999 |
A descriptive analysis of asthma in the U.S. Navy Submarine Force.
Topics: Adult; Asthma; Bronchoconstrictor Agents; Disability Evaluation; Humans; Mass Screening; Methacholine Chloride; Military Personnel; Prevalence; Racial Groups; Retrospective Studies; Risk Factors; Sensitivity and Specificity; Severity of Illness Index; Skin Tests; Socioeconomic Factors; Spirometry; Submarine Medicine; United States | 1999 |
Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Chromosome Mapping; Chromosomes; Genetic Linkage; Genotype; Male; Methacholine Chloride; Mice; Mice, Inbred A; Mice, Inbred C3H; Quantitative Trait, Heritable | 1999 |
Do subjects with asthma have greater perception of acute bronchoconstriction than smokers with airflow limitation?
Topics: Aged; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Cross-Sectional Studies; Female; Health Knowledge, Attitudes, Practice; Humans; Male; Methacholine Chloride; Middle Aged; Regression Analysis; Respiratory Function Tests; Severity of Illness Index; Smoking | 1999 |
Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999.
Topics: Administration, Inhalation; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Exercise Test; Humans; Methacholine Chloride; Nebulizers and Vaporizers; Respiratory Function Tests | 2000 |
Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthma.
Topics: Administration, Intranasal; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Movement; Disease Models, Animal; Eosinophils; Female; Humans; Immunoglobulin E; Injections, Intraperitoneal; Leukocytes, Mononuclear; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucus; Ovalbumin; Receptors, Interleukin-4; Solubility | 2000 |
Use of peak flow variability and methacholine responsiveness in predicting changes from pre-test diagnosis of asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Confidence Intervals; Disease Progression; Female; Humans; Male; Methacholine Chloride; Middle Aged; Odds Ratio; Peak Expiratory Flow Rate; Predictive Value of Tests; Probability; Retrospective Studies; Sensitivity and Specificity | 1999 |
Ventilation inhomogeneity assessed by nitrogen washout and ventilation-perfusion mismatch by capnography in stable and induced airway obstruction.
Topics: Adolescent; Adult; Asthma; Breath Tests; Bronchial Provocation Tests; Bronchoconstrictor Agents; Capnography; Child; Cystic Fibrosis; Forced Expiratory Volume; Humans; Methacholine Chloride; Nitrogen; Ventilation-Perfusion Ratio; Vital Capacity | 2000 |
Sequential development of airway hyperresponsiveness and acute airway obstruction in a mouse model of allergic inflammation.
Topics: Airway Obstruction; Airway Resistance; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Immunoglobulin E; Immunoglobulin G; Maximal Expiratory Flow Rate; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Plethysmography, Whole Body; Tidal Volume | 2000 |
Early increase in urinary leukotriene E4 (LTE4) is dependent on allergen dose inhaled during bronchial challenge in asthmatic subjects.
Topics: Adolescent; Adult; Allergens; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Leukotriene E4; Male; Methacholine Chloride; Middle Aged | 1999 |
Late asthmatic reaction with airway inflammation but without airway hyperresponsiveness.
Topics: Acrylates; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchopneumonia; Eosinophilia; Eosinophils; Forced Expiratory Volume; Humans; Intradermal Tests; Leukocyte Count; Lung; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Occupational Exposure; Sputum | 2000 |
Effect of suplatast tosilate (IPD-1151T) on a mouse model of asthma: inhibition of eosinophilic inflammation and bronchial hyperresponsiveness.
Topics: Animals; Anti-Allergic Agents; Arylsulfonates; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Eosinophilia; Female; Immunoglobulin E; Immunoglobulin G; Lung; Methacholine Chloride; Mice; Ovalbumin; Sulfonium Compounds | 2000 |
Increased eosinophil cation protein level in sensitized nonasthmatics is linked to subsequent hyperresponsiveness to methacholine. The Odense Schoolchild Study.
Topics: Adolescent; Adult; Allergens; Asthma; Blood Proteins; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Eosinophil Granule Proteins; Eosinophils; Female; Humans; Hypersensitivity; Immunoglobulin E; Leukocyte Count; Male; Methacholine Chloride; Prospective Studies; Ribonucleases; Skin Tests; Surveys and Questionnaires | 2000 |
Baseline airway hyperresponsiveness and its reversible component: role of airway inflammation and airway calibre.
Topics: Administration, Inhalation; Adult; Anti-Asthmatic Agents; Asthma; Beclomethasone; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Fenoterol; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Nitric Oxide; Sputum | 2000 |
Differences in airway responsiveness to acetaldehyde and methacholine in asthma and chronic bronchitis.
Topics: Acetaldehyde; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Bronchoconstrictor Agents; Diagnosis, Differential; Female; Humans; Lung Diseases, Obstructive; Male; Methacholine Chloride; Middle Aged; Sensitivity and Specificity; Smoking | 2000 |
Recombinant human platelet-activating factor-acetylhydrolase inhibits airway inflammation and hyperreactivity in mouse asthma model.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Movement; Disease Models, Animal; Eosinophils; Female; Humans; Interleukin-5; Lung; Macrophages; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucus; Phospholipases A; Platelet Activating Factor; Recombinant Proteins | 2000 |
Too hot to handle: an unusual exposure of HDI in specialty painters.
Topics: Adult; Air Pollutants, Occupational; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cost of Illness; Cross-Linking Reagents; Cyanates; Dermatitis, Contact; Dyspnea; Exanthema; Follow-Up Studies; Hot Temperature; Humans; Isocyanates; Male; Methacholine Chloride; Occupational Diseases; Occupational Exposure; Paint; Spirometry; Volatilization | 2000 |
Bronchial hyperresponsiveness in children and adolescents with Crohn's disease.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Crohn Disease; Female; Humans; Male; Methacholine Chloride; Respiratory Hypersensitivity; Risk Factors | 2000 |
Inhaled mannitol identifies methacholine-responsive children with active asthma.
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Diuretics, Osmotic; Female; Forced Expiratory Volume; Humans; Male; Mannitol; Methacholine Chloride; Nebulizers and Vaporizers; Oxygen; Powders; Time Factors | 2000 |
Airway distensibility in healthy and asthmatic subjects: effect of lung volume history.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Carbon Dioxide; Female; Humans; Lung Compliance; Lung Volume Measurements; Male; Methacholine Chloride; Reference Values; Regression Analysis; Reproducibility of Results; Respiratory Mechanics | 2000 |
Different airway responsiveness profiles in atopic asthma, nonatopic asthma, and Sjögren's syndrome. BHR Study Group. Bronchial hyperresponsiveness.
Topics: Adenosine Monophosphate; Adolescent; Adult; Aged; Asthma; Blood Proteins; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cold Temperature; Dose-Response Relationship, Drug; Eosinophil Granule Proteins; Eosinophil Peroxidase; Eosinophils; Female; Humans; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Peroxidases; Ribonucleases; Sjogren's Syndrome | 2000 |
Ethnic differences: word descriptors used by African-American and white asthma patients during induced bronchoconstriction.
Topics: Administration, Inhalation; Adult; Asthma; Black People; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cross-Cultural Comparison; Cross-Sectional Studies; Dyspnea; Female; Forced Expiratory Volume; Humans; Language; Male; Methacholine Chloride; Surveys and Questionnaires; White People | 2000 |
Atopy in childhood. II. Relationship to airway responsiveness, hay fever and asthma.
Topics: Adolescent; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cats; Cohort Studies; Comorbidity; Female; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride; Mites; New Zealand; Respiratory Sounds; Rhinitis, Allergic, Seasonal; Skin Tests; Spirometry; Surveys and Questionnaires | 1993 |
Airway inflammation in asthma and perennial allergic rhinitis. Relationship with nonspecific bronchial responsiveness and maximal airway narrowing.
Topics: Adolescent; Adult; Allergens; Animals; Antigens, Dermatophagoides; Asthma; Blood Proteins; Bronchial Hyperreactivity; Bronchial Provocation Tests; Chymases; Eosinophil Granule Proteins; Eosinophils; Female; Glycoproteins; Humans; Immunoglobulin E; Inflammation Mediators; Interleukin-5; Leukocyte Count; Male; Methacholine Chloride; Mites; Rhinitis, Allergic, Perennial; Ribonucleases; Serine Endopeptidases; Sputum; Tryptases | 2000 |
Effect of aerosolized administration of KF19514, a phosphodiesterase 4 inhibitor, on bronchial hyperresponsiveness and airway inflammation induced by antigen inhalation in guinea-pigs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Inhalation; Aerosols; Animals; Antigens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Guinea Pigs; Imidazoles; Male; Methacholine Chloride; Naphthyridines; Ovalbumin; Phosphodiesterase Inhibitors; Pyridones | 2000 |
Increased numbers of both airway basophils and mast cells in sputum after allergen inhalation challenge of atopic asthmatics.
Topics: Adult; Allergens; Asthma; Basophils; Bronchial Provocation Tests; Cell Count; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Male; Mast Cells; Methacholine Chloride; Middle Aged; Sputum | 2000 |
Factors related to methacholine airway responsiveness in children.
Topics: Age Factors; Asthma; Body Height; Bronchial Provocation Tests; Child; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Maximal Midexpiratory Flow Rate; Methacholine Chloride; Respiratory Sounds; Spirometry; Vital Capacity | 2000 |
Racial differences in physiologic parameters related to asthma among middle-class children.
Topics: Asthma; Black People; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Cross-Sectional Studies; Female; Forced Expiratory Volume; Humans; Immunoglobulin E; Male; Methacholine Chloride; Michigan; Pregnancy; Respiratory Hypersensitivity; White People | 2000 |
Irritant-induced asthma: clinical and functional aspects.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Environmental Exposure; Female; Humans; Irritants; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Respiratory Function Tests; Skin Tests; Sputum | 2000 |
Exhaled nitric oxide, serum ECP and airway responsiveness in mild asthmatic children.
Topics: Adolescent; Asthma; Blood Proteins; Bronchoconstrictor Agents; Child; Cross-Sectional Studies; Eosinophil Granule Proteins; Forced Expiratory Volume; Humans; Methacholine Chloride; Nitric Oxide; Respiration; Ribonucleases; Severity of Illness Index | 2000 |
Combined use of exhaled nitric oxide and airway hyperresponsiveness in characterizing asthma in a large population survey.
Topics: Adolescent; Adult; Asthma; Bronchoconstrictor Agents; Female; Humans; Male; Methacholine Chloride; Nitric Oxide; Respiration; Respiratory Hypersensitivity | 2000 |
Relationship between increased airway responsiveness and asthma severity in the childhood asthma management program.
Topics: Adolescent; Asthma; Bronchoconstrictor Agents; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Program Development; Severity of Illness Index | 2000 |
Effects of pranlukast, a cysteinyl leukotriene antagonist, on bronchial responsiveness to methacholine in aspirin-intolerant asthmatics treated with corticosteroids.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aspirin; Asthma; Bronchial Hyperreactivity; Chromones; Drug Tolerance; Female; Humans; Leukotriene Antagonists; Male; Methacholine Chloride; Middle Aged | 2000 |
Ventilatory support by tracheal gas insufflation and chest vibration during bronchoconstriction.
Topics: Animals; Asthma; Bronchoconstriction; Dogs; Electrocardiography; Hemodynamics; Insufflation; Intubation, Intratracheal; Male; Methacholine Chloride; Pulmonary Gas Exchange; Respiration, Artificial; Vibration | 2000 |
Environmental exposure to air pollution and allergens and peak flow changes.
Topics: Adult; Aged; Air Pollutants; Allergens; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Lung Diseases, Obstructive; Male; Methacholine Chloride; Middle Aged; Nitrogen Dioxide; Ozone; Peak Expiratory Flow Rate; Pollen; Spores, Fungal | 2000 |
Quality of dyspnea in bronchoconstriction differs from external resistive loads.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Dyspnea; Female; Humans; Male; Methacholine Chloride; Sensation; Surveys and Questionnaires | 2000 |
Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice.
Topics: Allergens; Animals; Asthma; Disease Models, Animal; Mast Cells; Methacholine Chloride; Mice; Ovalbumin; Respiratory Hypersensitivity; Sodium Chloride | 2000 |
Effect of TEI-9874, an inhibitor of immunoglobulin E production, on allergen-induced asthmatic model in rats.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Asthma; Benzeneacetamides; Benzoates; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Enzyme-Linked Immunosorbent Assay; Immunoglobulin E; Immunoglobulin G; Indicators and Reagents; Methacholine Chloride; Naphthalenes; Ovalbumin; Rats; Rats, Inbred BN; Respiratory Mechanics | 2000 |
Suppression of neural activity of bronchial irritant receptors by surface-active phospholipid in comparison with topical drugs commonly prescribed for asthma.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Anti-Inflammatory Agents; Asthma; Bronchi; Bronchial Provocation Tests; Chemoreceptor Cells; Hydrocortisone; Male; Methacholine Chloride; Phospholipids; Pulmonary Surfactants; Rats; Rats, Wistar; Respiratory Mucosa; Vagus Nerve | 2000 |
Efficacy and safety of methacholine bronchial challenge performed by auscultation in young asthmatic children.
Topics: Adolescent; Adult; Asthma; Auscultation; Bronchial Provocation Tests; Child; Child, Preschool; Female; Humans; Male; Methacholine Chloride; Predictive Value of Tests; Respiratory Sounds | 2000 |
International assessment of the internal consistency of respiratory symptoms. European Community Respiratory Health Study (ECRHS).
Topics: Adult; Asthma; Bronchial Provocation Tests; Cross-Cultural Comparison; Factor Analysis, Statistical; Female; Humans; International Cooperation; Male; Methacholine Chloride; Respiratory Hypersensitivity; Respiratory Sounds; Sickness Impact Profile; Surveys and Questionnaires | 2000 |
Adolescents in clinical remission of atopic asthma have elevated exhaled nitric oxide levels and bronchial hyperresponsiveness.
Topics: Adenosine Monophosphate; Adolescent; Adult; Asthma; Breath Tests; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cross-Sectional Studies; Female; Humans; Male; Methacholine Chloride; Nitric Oxide; Remission, Spontaneous; Respiratory Hypersensitivity | 2000 |
Assessment of magnesium status in patients with bronchial asthma.
Topics: Adolescent; Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Humans; Magnesium; Magnesium Deficiency; Male; Methacholine Chloride; Middle Aged; Risk Factors | 2000 |
Borg scores before and after challenge with adenosine 5'-monophosphate and methacholine in subjects with COPD and asthma.
Topics: Adenosine Monophosphate; Adolescent; Adult; Aged; Asthma; Bronchial Provocation Tests; Dyspnea; Female; Forced Expiratory Volume; Humans; Lung Diseases, Obstructive; Male; Methacholine Chloride; Middle Aged; Smoking | 2000 |
Screening for bronchial hyperresponsiveness using methacholine and adenosine monophosphate. Relationship to asthma severity and beta(2)-receptor genotype.
Topics: Adenosine Monophosphate; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Genotype; Humans; Male; Mass Screening; Methacholine Chloride; Middle Aged; Polymorphism, Genetic; Predictive Value of Tests; Receptors, Adrenergic, beta-2; Retrospective Studies | 2000 |
Mucosal IL-12 inhibits airway reactivity to methacholine and respiratory failure in murine asthma.
Topics: Adjuvants, Immunologic; Allergens; Asthma; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Interleukin-12; Intubation, Intratracheal; Methacholine Chloride; Pollen; Respiratory Insufficiency; Respiratory Mucosa | 2000 |
Poor perception of airway obstruction in children with asthma.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Case-Control Studies; Child; Dyspnea; Female; Humans; Male; Methacholine Chloride; Pain Measurement; Perception; Risk Factors; Severity of Illness Index | 2000 |
Application of an algorithm for the diagnosis of asthma in Chinese families: limitations and alternatives for the phenotypic assessment of asthma in family-based genetic studies.
Topics: Adolescent; Adult; Algorithms; Asthma; Bronchial Provocation Tests; China; Female; Humans; Male; Methacholine Chloride; Middle Aged; Netherlands; Phenotype; Skin Tests; Spirometry | 2000 |
Exhaled nitric oxide following leukotriene E(4) and methacholine inhalation in patients with asthma.
Topics: Administration, Inhalation; Adult; Airway Resistance; Asthma; Breath Tests; Bronchial Provocation Tests; Cell Count; Eosinophils; Female; Humans; Leukotriene E4; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Sputum | 2000 |
Bronchial hyperresponsiveness in subjects with gastroesophageal reflux.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Case-Control Studies; Female; Gastroesophageal Reflux; Humans; Male; Methacholine Chloride; Middle Aged; Prevalence | 2000 |
Time course of inflammatory and remodeling events in a murine model of asthma: effect of steroid treatment.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Cell Division; Dexamethasone; Disease Models, Animal; Eosinophils; Epithelial Cells; Fibronectins; Immunoglobulin E; Interleukin-4; Interleukin-5; Leukocyte Count; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mucus; Ovalbumin; Plasma; Pulmonary Alveoli; Respiratory Mucosa; Species Specificity; Time Factors | 2000 |
Enhancement of goblet cell hyperplasia and airway hyperresponsiveness by salbutamol in a rat model of atopic asthma.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Anti-Inflammatory Agents; Asthma; Bronchoconstrictor Agents; Eosinophils; Goblet Cells; Hyperplasia; Male; Methacholine Chloride; Methylprednisolone; Models, Animal; Rats; Respiratory Hypersensitivity | 2001 |
Natural exposure to pollen reduces the threshold but does not change the pattern of response to the allergen in allergic subjects.
Topics: Adolescent; Adult; Allergens; Analysis of Variance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Humans; Male; Methacholine Chloride; Pollen; Seasons | 2000 |
Low physical fitness in childhood is associated with the development of asthma in young adulthood: the Odense schoolchild study.
Topics: Asthma; Bronchi; Bronchial Provocation Tests; Child; Exercise Test; Female; Health Surveys; Humans; Male; Methacholine Chloride; Odds Ratio; Physical Fitness; Prospective Studies; Risk Factors | 2000 |
Oilseed rape flour: another allergen causing occupational asthma among farmers.
Topics: Adult; Agriculture; Allergens; Asthma; Blood Proteins; Brassica; Bronchial Provocation Tests; Bronchoconstrictor Agents; Eosinophil Granule Proteins; Eosinophils; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Ribonucleases; Skin Tests; Sputum; Time Factors | 2001 |
Linkage between bronchial responsiveness to methacholine and gene markers of IL-4 cytokine gene cluster and T-cell receptor alpha/delta gene complex in Korean nuclear families.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Child; Child, Preschool; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 5; Female; Genetic Linkage; Humans; Immunoglobulin E; Interleukin-4; Korea; Male; Methacholine Chloride; Nuclear Family; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Antigen, T-Cell, gamma-delta; Skin | 2001 |
The lack of the bronchoprotective and not the bronchodilatory ability of deep inspiration is associated with airway hyperresponsiveness.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Female; Forced Expiratory Volume; Humans; Inhalation; Male; Methacholine Chloride; Middle Aged; Reference Values; Rhinitis, Allergic, Perennial; Risk Factors | 2001 |
Perception of methacholine-induced airway obstruction in asthmatics.
Topics: Adolescent; Adult; Aged; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Female; Humans; Male; Methacholine Chloride; Middle Aged | 2000 |
Relationship between bronchial hyperresponsiveness and development of asthma in wheezy infants.
Topics: Asthma; Blood Gas Monitoring, Transcutaneous; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchiolitis; Bronchitis; Bronchoconstrictor Agents; Case-Control Studies; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Male; Methacholine Chloride; Respiratory Sounds; Time Factors | 2001 |
Association of airway responsiveness with asthma and persistent wheeze in a Chinese population.
Topics: Adolescent; Adult; Aged; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Child; China; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Prevalence; Respiratory Sounds; ROC Curve; Sensitivity and Specificity | 2001 |
Methacholine challenge testing in Reserve Officer Training Corps cadets.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Case-Control Studies; Cohort Studies; False Positive Reactions; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Military Personnel; Prevalence; Prospective Studies; United States | 2001 |
[The experimental and clinical study of heliox in treating bronchial asthma].
Topics: Adult; Aged; Airway Resistance; Animals; Asthma; Bronchoconstriction; Dogs; Helium; Humans; Lung Compliance; Male; Methacholine Chloride; Middle Aged; Oxygen; Random Allocation; Respiration, Artificial; Respiratory Function Tests | 1998 |
Respiratory effects of a single dive to 50 meters in sport divers with asymptomatic respiratory atopy.
Topics: Adult; Airway Resistance; Asthma; Bronchoconstrictor Agents; Diving; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride; Respiratory Function Tests; Respiratory Tract Diseases | 2001 |
Incidence and host determinants of probable occupational asthma in apprentices exposed to laboratory animals.
Topics: Adult; Allergens; Animal Husbandry; Animal Technicians; Animals; Animals, Laboratory; Asthma; Bronchial Provocation Tests; Case-Control Studies; Cohort Studies; Female; Humans; Incidence; Male; Methacholine Chloride; Mice; Multivariate Analysis; Occupational Diseases; Patch Tests; Proportional Hazards Models; Prospective Studies; Rabbits; Rats; Risk Factors | 2001 |
Correlation between airway hyperresponsiveness and airway inflammation in a young adult population: eosinophil, ECP, and cytokine levels in induced sputum.
Topics: Adult; Animals; Antigens, Dermatophagoides; Asthma; Blood Proteins; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cytokines; Eosinophil Granule Proteins; Eosinophils; Female; Glycoproteins; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunoglobulin E; Male; Methacholine Chloride; Pulmonary Eosinophilia; Radioallergosorbent Test; Respiratory Function Tests; Ribonucleases; Sputum; Tumor Necrosis Factor-alpha | 2001 |
Enhanced airway Th2 response after allergen challenge in mice deficient in CC chemokine receptor-2 (CCR2).
Topics: Administration, Inhalation; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Chemokine CCL2; Disease Models, Animal; Eosinophilia; Immunoglobulin E; Immunoglobulin G; Injections, Intraperitoneal; Lung; Lymphocyte Activation; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Ovalbumin; Receptors, CCR2; Receptors, Chemokine; Th2 Cells | 2001 |
The effect of immunotherapy on nonspecific bronchial hyperresponsiveness in bronchial asthma and allergic rhinitis.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Humans; Immunoglobulin E; Immunotherapy; Methacholine Chloride; Middle Aged; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 2001 |
Mild exacerbations and eosinophilic inflammation in patients with stable, well-controlled asthma after 1 year of follow-up.
Topics: Administration, Inhalation; Administration, Topical; Adolescent; Adrenergic beta-Agonists; Adult; Aged; Anti-Inflammatory Agents; Asthma; Blood Proteins; Bronchial Provocation Tests; Bronchodilator Agents; Budesonide; Eosinophil Granule Proteins; Eosinophils; Follow-Up Studies; Forced Expiratory Volume; Glucocorticoids; Humans; Inflammation; Leukocyte Count; Longitudinal Studies; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Ribonucleases; Risk Factors | 2001 |
Comparisons of peak diurnal expiratory flow variation, postbronchodilator FEV(1) responses, and methacholine inhalation challenges in the evaluation of suspected asthma.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Child; Circadian Rhythm; Forced Expiratory Volume; Humans; Methacholine Chloride; Peak Expiratory Flow Rate; Predictive Value of Tests; Prospective Studies; Radiography, Thoracic; Respiratory Function Tests; Sensitivity and Specificity; Spirometry | 2001 |
Methacholine inhalation challenge: a shorter, cheaper and safe approach.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Retrospective Studies; Vital Capacity | 2001 |
Bronchoconstriction induced by inhaled adenosine 5'-monophosphate in subjects with allergic rhinitis.
Topics: Adenosine Monophosphate; Administration, Inhalation; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Rhinitis; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Vital Capacity | 2001 |
Effects of BCG on ovalbumin-induced bronchial hyperreactivity in a guinea pig asthma model.
Topics: Animals; Asthma; BCG Vaccine; Biopsy; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Disease Models, Animal; Flow Cytometry; Guinea Pigs; Immunoglobulin G; Immunohistochemistry; Lung; Lymphocyte Subsets; Male; Methacholine Chloride; Nebulizers and Vaporizers; Ovalbumin; Skin; Time Factors | 2001 |
Allergen-induced changes in airway responsiveness are not related to indices of airway edema.
Topics: Airway Resistance; Allergens; Asthma; Blood Proteins; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoscopy; Cytokines; Edema; Eosinophil Granule Proteins; Fibrinogen; Gene Expression Profiling; Humans; Hypersensitivity, Immediate; Interferon-gamma; Interleukin-2; Interleukin-4; Interleukin-5; Methacholine Chloride; Respiratory Tract Diseases; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleases; RNA, Messenger; Th2 Cells | 2001 |
Normally suppressing CD40 coregulatory signals delivered by airway macrophages to TH2 lymphocytes are defective in patients with atopic asthma.
Topics: Antibodies, Monoclonal; Antigens, CD; Asthma; B7-1 Antigen; B7-2 Antigen; Bronchial Provocation Tests; Bronchoscopy; CD40 Antigens; Coculture Techniques; HLA-DR Antigens; Humans; Hypersensitivity, Immediate; Interferon-gamma; Interleukin-12; Interleukin-5; Macrophages, Alveolar; Membrane Glycoproteins; Methacholine Chloride; Recombinant Proteins; Signal Transduction; Th2 Cells | 2001 |
Validation of a new questionnaire on asthma, allergic rhinitis, and conjunctivitis in young adults.
Topics: Adolescent; Adult; Age Distribution; Asthma; Conjunctivitis, Allergic; Female; Finland; Forced Expiratory Volume; Humans; Immunoglobulin E; Intradermal Tests; Male; Mass Screening; Methacholine Chloride; Rhinitis, Allergic, Perennial; Sensitivity and Specificity; Students; Surveys and Questionnaires; Universities | 2001 |
Occupational asthma caused by exposure to cyanoacrylate.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cyanoacrylates; Environmental Monitoring; Eosinophils; Female; Forced Expiratory Volume; Humans; Intradermal Tests; Methacholine Chloride; Middle Aged; Occupational Diseases; Occupational Exposure; Peak Expiratory Flow Rate; Sputum; Time Factors | 2001 |
Relationship between bronchial hyperresponsiveness and development of asthma in children with chronic cough.
Topics: Administration, Inhalation; Adolescent; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Child; Child, Preschool; Chronic Disease; Cough; Female; Humans; Infant; Male; Methacholine Chloride; Respiratory Tract Infections; Risk Factors | 2001 |
L-Selectin is required for the development of airway hyperresponsiveness but not airway inflammation in a murine model of asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Flow Cytometry; Humans; Immunoglobulin E; Inflammation; L-Selectin; Leukocyte Count; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Ovalbumin | 2001 |
Changes in sputum cell counts after exposure to occupational agents: what do they mean?
Topics: Adult; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cats; Edible Grain; Eosinophils; Female; Flour; Guinea Pigs; Humans; Isocyanates; Leukocyte Count; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Occupational Exposure; Sputum | 2001 |
Changes in FVC during methacholine-induced bronchoconstriction in elderly patients with asthma: bronchial hyperresponsiveness and aging.
Topics: Adult; Aged; Aging; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Vital Capacity | 2001 |
How best to measure airway responsiveness.
Topics: Adenosine Monophosphate; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Humans; Inflammation; Methacholine Chloride | 2001 |
Acute changes in bronchoconstriction influences exhaled nitric oxide level.
Topics: Adult; Albuterol; Asthma; Breath Tests; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Humans; Male; Methacholine Chloride; Nitric Oxide; Respiration | 2001 |
Airway responsiveness as a direct factor contributing to the dyspnoea perception in asthma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Attitude to Health; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Dyspnea; Female; Forced Expiratory Volume; Humans; Linear Models; Male; Methacholine Chloride; Middle Aged; Regression Analysis; Severity of Illness Index | 2001 |
Asthma severity and inflammation markers in children.
Topics: Adolescent; Adult; Asthma; Biomarkers; Blood Proteins; Breath Tests; Bronchial Provocation Tests; Bronchitis; Bronchoconstrictor Agents; Child; Cross-Sectional Studies; Eosinophil Granule Proteins; Eosinophils; Female; Humans; Leukocyte Count; Male; Methacholine Chloride; Nitric Oxide; Ribonucleases; Sputum | 2001 |
Age-dependent relationship between bronchial hyperresponsiveness to methacholine and total serum IgE level in asthmatic children.
Topics: Administration, Inhalation; Adolescent; Age Factors; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Child; Child, Preschool; Female; Food Hypersensitivity; Humans; Immunoglobulin E; Infant; Male; Methacholine Chloride; Milk; Ovalbumin; Oxygen; Partial Pressure; Radioallergosorbent Test | 2001 |
The feasibility of airways hyperresponsiveness as an inclusion criterion for studies on childhood asthma.
Topics: Androstadienes; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Clinical Trials as Topic; Feasibility Studies; Female; Fluticasone; Humans; Long-Term Care; Male; Methacholine Chloride; Patient Selection; Substance Withdrawal Syndrome | 2001 |
Role of nitric oxide and superoxide in allergen-induced airway hyperreactivity after the late asthmatic reaction in guinea-pigs.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Guinea Pigs; Histamine; Methacholine Chloride; NG-Nitroarginine Methyl Ester; Nitric Oxide; Ovalbumin; Perfusion; Respiration; Superoxide Dismutase; Superoxides; Trachea | 2001 |
Inflammatory and mechanical factors of allergen-induced bronchoconstriction in mild asthma and rhinitis.
Topics: Adult; Allergens; Asthma; Basement Membrane; Biopsy; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Bronchoconstrictor Agents; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Regression Analysis; Rhinitis; Vital Capacity | 2001 |
On the functional consequences of bronchial basement membrane thickening.
Topics: Adult; Asthma; Basement Membrane; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Eosinophils; Female; Forced Expiratory Volume; Humans; Male; Mast Cells; Methacholine Chloride; Pulmonary Disease, Chronic Obstructive; Respiratory Mucosa; Rhinitis, Allergic, Perennial; Vital Capacity | 2001 |
Homeokinesis and short-term variability of human airway caliber.
Topics: Adolescent; Adult; Aged; Airway Obstruction; Airway Resistance; Asthma; Bronchi; Bronchoconstrictor Agents; Entropy; Female; Homeostasis; Humans; Male; Methacholine Chloride; Middle Aged; Models, Biological; Muscle, Smooth; Posture; Trachea | 2001 |
Low-attenuation areas of the lungs on high-resolution computed tomography in asthma.
Topics: Administration, Inhalation; Aged; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Female; Humans; Immunoglobulin E; Lung Diseases, Obstructive; Male; Methacholine Chloride; Middle Aged; Spirometry; Tomography, X-Ray Computed | 2001 |
A new asthma severity index: a predictor of near-fatal asthma?
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Predictive Value of Tests; Risk Factors; Severity of Illness Index; Vital Capacity | 2001 |
Mycobacterial antigens attenuate late phase response, airway hyperresponsiveness, and bronchoalveolar lavage eosinophilia in a mouse model of bronchial asthma.
Topics: Algorithms; Animals; Antigens, Bacterial; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Eosinophilia; Interleukin-12; Interleukin-4; Methacholine Chloride; Mice; Mice, Inbred BALB C; Muscarinic Agonists; Mycobacterium; Mycobacterium bovis | 2001 |
Cockroach allergen-induced eosinophilic airway inflammation in HLA-DQ/human CD4(+) transgenic mice.
Topics: Allergens; Animals; Antigen Presentation; Antigens, Plant; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; CD4 Antigens; Cockroaches; Cytokines; HLA-DQ Antigens; Humans; Immunoglobulin E; Lung; Methacholine Chloride; Mice; Mice, Transgenic; Pulmonary Eosinophilia; Respiratory Hypersensitivity | 2001 |
CCSP modulates airway dysfunction and host responses in an Ova-challenged mouse model.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Chemokine CXCL2; Chemokines; Enzyme Inhibitors; Female; Histocytochemistry; Humans; Inflammation; Lung; Methacholine Chloride; Mice; Mice, Knockout; Neutrophils; Ovalbumin; Peroxidase; Proteins; Uteroglobin | 2001 |
Increased level of bronchial responsiveness in inactive children with asthma.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Case-Control Studies; Child; Cross-Sectional Studies; Dose-Response Relationship, Drug; Exercise; Female; Forced Expiratory Volume; Humans; Linear Models; Male; Methacholine Chloride | 2001 |
A genomewide search for quantitative-trait loci underlying asthma.
Topics: Adult; Allergens; Animals; Antigens, Dermatophagoides; Asthma; Bronchoconstrictor Agents; China; Chromosome Mapping; Chromosomes, Human; Chromosomes, Human, Pair 2; Cockroaches; Eosinophils; Female; Forced Expiratory Volume; Genetic Linkage; Glycoproteins; Humans; Immunoglobulin E; Leukocyte Count; Male; Methacholine Chloride; Phenotype; Quantitative Trait, Heritable; Skin Tests; Vital Capacity | 2001 |
Immunostimulatory DNA sequences inhibit respiratory syncytial viral load, airway inflammation, and mucus secretion.
Topics: Adjuvants, Immunologic; Animals; Asthma; Bronchial Hyperreactivity; Bronchitis; Bronchoconstrictor Agents; Cell Line; DNA; Female; Interferon-gamma; Interferons; Interleukin-13; Lung; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mucus; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Viral Load; Virus Replication | 2001 |
Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma.
Topics: Adult; Age Factors; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Linear Models; Lung Diseases, Obstructive; Male; Methacholine Chloride; Middle Aged; Neutrophil Infiltration; Pulmonary Eosinophilia; Retrospective Studies; Sputum | 2001 |
Immunostimulatory DNA mediates inhibition of eosinophilic inflammation and airway hyperreactivity independent of natural killer cells in vivo.
Topics: Adjuvants, Immunologic; Animals; Asthma; Bone Marrow Diseases; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cells, Cultured; DNA; Eosinophilia; Female; Interferon-gamma; Killer Cells, Natural; Lymphocyte Depletion; Methacholine Chloride; Mice; Mice, Inbred C57BL; Ovalbumin; Pulmonary Eosinophilia | 2001 |
Relationship between bronchial responsiveness and clinical evolution in infants who wheeze: a four-year prospective study.
Topics: Asthma; Bronchi; Bronchoconstrictor Agents; Child, Preschool; Disease Progression; Female; Follow-Up Studies; Humans; Infant; Male; Methacholine Chloride; Prospective Studies; Respiratory Sounds; Time Factors | 2001 |
Flt3 ligand: a novel cytokine prevents allergic asthma in a mouse model.
Topics: Airway Resistance; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cell Differentiation; Dendritic Cells; Drug Administration Schedule; Female; Immunization; Immunoglobulin E; Interferon-gamma; Interleukin-12; Interleukin-4; Interleukin-5; Membrane Proteins; Methacholine Chloride; Mice; Mice, Inbred BALB C; Models, Animal; Ovalbumin; Pulmonary Eosinophilia; Th2 Cells | 2001 |
CTLA4-IgG reverses asthma manifestations in a mild but not in a more "severe" ongoing murine model.
Topics: Abatacept; Aerosols; Allergens; Aluminum Hydroxide; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Antigens, CD; Antigens, Differentiation; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cells, Cultured; CTLA-4 Antigen; Cytokines; Dexamethasone; Disease Models, Animal; Emulsions; Eosinophils; Immunization; Immunoconjugates; Immunoglobulin E; Immunosuppressive Agents; Interleukin-5; Leukocyte Count; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nasal Provocation Tests; Ovalbumin; Specific Pathogen-Free Organisms; T-Lymphocyte Subsets | 2001 |
Summarizing methacholine challenges in clinical research.
Topics: Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Humans; Methacholine Chloride | 2001 |
Body mass index and asthma in adults in families of subjects with asthma in Anqing, China.
Topics: Adult; Age Distribution; Asthma; Body Mass Index; Bronchial Provocation Tests; Bronchoconstrictor Agents; China; Cross-Sectional Studies; Female; Humans; Logistic Models; Male; Methacholine Chloride; Multivariate Analysis; Obesity; Odds Ratio; Pedigree; Residence Characteristics; Rural Health; Sex Distribution; Smoking; Thinness | 2001 |
Streamlining methacholine challenge testing.
Topics: Asthma; Bronchial Provocation Tests; Diagnosis, Differential; Dose-Response Relationship, Drug; Forced Expiratory Volume; Humans; Methacholine Chloride; Retrospective Studies | 2001 |
Methacholine challenge: test-shortening procedures.
Topics: Adolescent; Adult; Aged; Asthma; Bronchial Provocation Tests; Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Methacholine Chloride; Middle Aged; Predictive Value of Tests | 2001 |
Construction of single-chain interleukin-12 DNA plasmid to treat airway hyperresponsiveness in an animal model of asthma.
Topics: Allergens; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; COS Cells; Disease Models, Animal; Female; Genetic Therapy; Immunotherapy; Inflammation; Interleukin-12; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Plasmids; Transfection; Vaccines, DNA | 2001 |
Modulation of airway responsiveness by anionic and cationic polyelectrolyte substances.
Topics: Airway Resistance; Animals; Asthma; Bronchoconstriction; Female; Guinea Pigs; Heparin, Low-Molecular-Weight; Male; Methacholine Chloride; Ovalbumin; Polyglutamic Acid; Polylysine | 2002 |
[The changes of protein kinase C activity in peripheral blood lymphocytes in asthmatic patients].
Topics: Adult; Asthma; Cells, Cultured; Female; Histamine; Humans; Leukocytes, Mononuclear; Lung; Lymphocytes; Male; Methacholine Chloride; Muscarinic Agonists; Protein Kinase C; Receptors, Interleukin-2 | 1999 |
Response of asthma-related voice dysfunction to allergen immunotherapy: a case report of confirmation by methacholine challenge.
Topics: Adult; Albuterol; Asthma; Bronchoconstrictor Agents; Bronchodilator Agents; Desensitization, Immunologic; Dust; Female; Humans; Methacholine Chloride; Pollen; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Voice Disorders | 2001 |
Core 2 oligosaccharides mediate eosinophil and neutrophil peritoneal but not lung recruitment.
Topics: Animals; Asthma; Bone Marrow; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Cell Movement; Eosinophils; Female; Gene Expression; Golgi Apparatus; Lung; Methacholine Chloride; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Acetylglucosaminyltransferases; Neutrophils; Oligosaccharides; Peritoneum; Peritonitis; Pneumonia; Reverse Transcriptase Polymerase Chain Reaction | 2002 |
Duration of steroid therapy determines dose-response effect.
Topics: Asthma; Beclomethasone; Breath Tests; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Methacholine Chloride; Nasal Provocation Tests; Nitric Oxide | 2002 |
[A study of airway reactivity and nature of chronic asthmatic bronchitis].
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis, Chronic; Bronchoconstrictor Agents; Eosinophil Cationic Protein; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Middle Aged | 1999 |
CXCR2 is necessary for the development and persistence of chronic fungal asthma in mice.
Topics: Animals; Aspergillus fumigatus; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Movement; Chemokine CCL11; Chemokine CCL4; Chemokine CCL5; Chemokine CXCL10; Chemokines, CC; Chemokines, CXC; Chronic Disease; Disease Models, Animal; Eosinophils; Female; Immunity, Innate; Immunoglobulin E; Interferon-gamma; Interleukin-12; Interleukin-4; Interleukin-5; Lung; Macrophage Inflammatory Proteins; Methacholine Chloride; Mice; Mice, Knockout; Neutrophils; Peroxidase; Receptors, Interleukin-8B; Spores, Fungal; T-Lymphocytes | 2002 |
Airway responsiveness and peak flow variability in the diagnosis of asthma for epidemiological studies.
Topics: Adult; Aged; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Epidemiologic Methods; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Prognosis; Respiratory Function Tests | 2001 |
[Computer analysis of respiratory sounds in bronchial obstruction evaluation in small children that do not collaborate with spirometry tests].
Topics: Asthma; Auscultation; Blood Gas Monitoring, Transcutaneous; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Child, Preschool; Female; Humans; Male; Methacholine Chloride; Respiratory Sounds; Signal Processing, Computer-Assisted | 2001 |
PC(20) adenosine 5'-monophosphate is more closely associated with airway inflammation in asthma than PC(20) methacholine.
Topics: Adenosine Monophosphate; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Forced Expiratory Volume; Humans; Methacholine Chloride; Predictive Value of Tests | 2002 |
[Agreement between tracheal auscultation and pulmonary function in methacholine bronchial inhalation challenge in asthmatic children].
Topics: Adolescent; Age Factors; Asthma; Auscultation; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Data Interpretation, Statistical; Forced Expiratory Volume; Humans; Methacholine Chloride; Models, Biological; Nebulizers and Vaporizers; Respiratory Sounds; Spirometry; Trachea | 2002 |
Vitamin A deficiency promotes bronchial hyperreactivity in rats by altering muscarinic M(2) receptor function.
Topics: Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Consciousness; Female; Methacholine Chloride; Radiopharmaceuticals; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptors, Muscarinic; Respiratory Mucosa; Specific Pathogen-Free Organisms; Technetium Tc 99m Pentetate; Vitamin A Deficiency | 2002 |
A comparison of the validity of different diagnostic tests in adults with asthma.
Topics: Adolescent; Adult; Aged; Airway Resistance; Albuterol; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Cross-Sectional Studies; Diagnosis, Differential; Eosinophils; Female; Forced Expiratory Volume; Humans; Leukocyte Count; Male; Methacholine Chloride; Middle Aged; Spirometry; Vital Capacity | 2002 |
CD4(+) T-lymphocytes regulate airway remodeling and hyper-reactivity in a mouse model of chronic asthma.
Topics: Allergens; Animals; Antibodies, Monoclonal; Asthma; Bronchi; Bronchial Hyperreactivity; CD4-Positive T-Lymphocytes; Chronic Disease; Disease Models, Animal; Female; Image Processing, Computer-Assisted; Immunization; Immunoglobulin G; Immunohistochemistry; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Specific Pathogen-Free Organisms | 2002 |
Nonlinearity of respiratory mechanics during bronchoconstriction in mice with airway inflammation.
Topics: Administration, Inhalation; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cell Count; Disease Models, Animal; Female; Lung Volume Measurements; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nonlinear Dynamics; Ovalbumin; Pneumonia; Positive-Pressure Respiration; Respiration, Artificial; Respiratory Mechanics | 2002 |
Airway responsiveness to inhaled acetaldehyde in subjects with allergic rhinitis: relationship to methacholine responsiveness.
Topics: Acetaldehyde; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Female; Humans; Hypersensitivity; Male; Methacholine Chloride; Rhinitis; Spirometry | 2002 |
A detailed genetic map of the chromosome 7 bronchial hyper-responsiveness locus.
Topics: Adolescent; Adult; Asthma; Bronchi; Centromere; Child; Chromosome Mapping; Chromosomes, Human, Pair 7; Dose-Response Relationship, Drug; Eosinophils; Genetic Linkage; Genetic Markers; Humans; Methacholine Chloride; Microsatellite Repeats; Middle Aged; Models, Genetic; Polymorphism, Genetic | 2002 |
Diagnosis of flour-induced occupational asthma in a cross-sectional study.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Cross-Sectional Studies; Female; Flour; Humans; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Skin Tests | 2002 |
Role of TNF-alpha and its 55 and 75 kDa receptors in bronchial hyperreactivity.
Topics: Adolescent; Adult; Antigens, CD; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Child, Preschool; Female; Humans; Male; Methacholine Chloride; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Statistics, Nonparametric; Tumor Necrosis Factor-alpha | 2002 |
The importance of maximal airway response to methacholine in the prediction of asthma development in patients with allergic rhinitis.
Topics: Adolescent; Airway Resistance; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Child Welfare; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Immunoglobulin E; Korea; Male; Methacholine Chloride; Predictive Value of Tests; Prevalence; Prospective Studies; Rhinitis, Allergic, Perennial; Sensitivity and Specificity; Skin Tests | 2002 |
Pulmonary function characteristics in patients with different patterns of methacholine airway hyperresponsiveness.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Prospective Studies | 2002 |
Airway and tissue mechanics in a murine model of asthma: alveolar capsule vs. forced oscillations.
Topics: Administration, Inhalation; Airway Resistance; Algorithms; Animals; Asthma; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Elasticity; Female; Inflammation; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pulmonary Alveoli; Respiration, Artificial; Respiratory Function Tests; Respiratory Mechanics; Respiratory System | 2002 |
Relationship of wheezing to airflow obstruction in asthmatic children and a history of cough-variant asthma.
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Cough; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Pulmonary Disease, Chronic Obstructive; Respiratory Sounds; Severity of Illness Index | 2002 |
Genetic analysis using DNA polymorphism of the linkage between chromosome 11q13 and atopy and bronchial hyperresponsiveness to methacholine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibody Specificity; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Child, Preschool; Chromosomes, Human, Pair 11; DNA; Female; Genetic Linkage; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Lod Score; Male; Methacholine Chloride; Middle Aged; Pedigree; Polymorphism, Restriction Fragment Length; Repetitive Sequences, Nucleic Acid; Skin Tests | 1992 |
Validity of methods used to test airway responsiveness in children.
Topics: Adolescent; Aerosols; Aging; Asthma; Body Weight; Bronchial Hyperreactivity; Child; Child, Preschool; Humans; Infant; Methacholine Chloride; Respiratory System | 1992 |
[Bronchial hyperreactivity in young patients with asthma].
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Respiratory Function Tests | 1992 |
Maximal airway narrowing in a general population.
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstriction; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Middle Aged; Respiratory Sounds; Sensitivity and Specificity; Smoking; Western Australia | 1992 |
A discriminant analysis applied to methacholine bronchoprovocation testing improves classification of patients as normal, asthma, or COPD.
Topics: Adult; Asthma; Bronchial Provocation Tests; Discriminant Analysis; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Lung Diseases, Obstructive; Methacholine Chloride; Middle Aged; Predictive Value of Tests; Sensitivity and Specificity; Vital Capacity | 1992 |
Unimodal distribution of bronchial hyperresponsiveness to methacholine in asthmatic patients.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Vital Capacity | 1992 |
Influence of short-term passive smoking on symptoms, lung mechanics and airway responsiveness in asthmatic subjects and healthy controls.
Topics: Adolescent; Adult; Aged; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Case-Control Studies; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Tobacco Smoke Pollution | 1992 |
Inhaled steroids modify bronchial responses to hyperosmolar saline.
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Beclomethasone; Bronchi; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Osmolar Concentration; Pilot Projects; Sodium Chloride | 1992 |
Associations between atopy, asthma history, respiratory function and non-specific bronchial hyperresponsiveness in unselected young asthmatics.
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Male; Maximal Midexpiratory Flow Rate; Methacholine Chloride; Rhinitis; Skin Tests | 1992 |
Effect of methacholine induced bronchoconstriction on the spectral characteristics of breath sounds in asthma.
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstriction; Forced Expiratory Volume; Humans; Methacholine Chloride; Reproducibility of Results; Respiratory Sounds | 1992 |
Partitioning of pulmonary responses to inhaled methacholine in subjects with asymptomatic asthma.
Topics: Adult; Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Catheterization; Dogs; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Respiratory Function Tests; Respiratory System; Vital Capacity | 1992 |
Risk factors for increased airway responsiveness to methacholine challenge among laboratory animal workers.
Topics: Adolescent; Adult; Animals; Animals, Laboratory; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Humans; Hypersensitivity; Male; Medical Laboratory Personnel; Methacholine Chloride; Middle Aged; Occupational Diseases; Risk Factors; Skin Tests | 1992 |
Repeatability of methacholine challenge in asthmatic children measured by change in transcutaneous oxygen tension.
Topics: Asthma; Blood Gas Monitoring, Transcutaneous; Bronchi; Bronchial Provocation Tests; Child; Dose-Response Relationship, Drug; Forced Expiratory Volume; Humans; Methacholine Chloride; Reproducibility of Results | 1992 |
Calibration of aerosol output from the Mefar dosimeter: implications for epidemiological studies.
Topics: Administration, Inhalation; Aerosols; Asthma; Bronchial Provocation Tests; Calibration; Epidemiologic Methods; Humans; Methacholine Chloride; Nebulizers and Vaporizers; Temperature; Weights and Measures | 1992 |
Changes in interleukin-1 and tumor necrosis factor production by peripheral blood monocytes after specific bronchoprovocation test in occupational asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Evaluation Studies as Topic; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Interleukin-1; Leukocyte Count; Methacholine Chloride; Middle Aged; Molecular Weight; Monocytes; Occupational Diseases; T-Lymphocyte Subsets; Time Factors; Tumor Necrosis Factor-alpha | 1992 |
Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma. Relationship to symptoms and bronchial responsiveness.
Topics: Adult; Asthma; Biopsy; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Eosinophils; Evaluation Studies as Topic; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Immunohistochemistry; Macrophages; Male; Methacholine Chloride; Middle Aged; Mucous Membrane; Neutrophils; Severity of Illness Index; T-Lymphocyte Subsets; T-Lymphocytes | 1992 |
Airway responsiveness: new concepts and concerns.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Humans; Infant; Inflammation; Methacholine Chloride | 1992 |
The effects of airway hyperresponsiveness, wheezing, and atopy on longitudinal pulmonary function in children: a 6-year follow-up study.
Topics: Adolescent; Age Factors; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Child, Preschool; Female; Forced Expiratory Volume; Humans; Longitudinal Studies; Lung; Male; Methacholine Chloride; Respiratory Sounds; Sex Factors; Skin Tests; Vital Capacity | 1992 |
Reduced subjective awareness of bronchoconstriction provoked by methacholine in elderly asthmatic and normal subjects as measured on a simple awareness scale.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Asthma; Awareness; Bronchoconstriction; Forced Expiratory Volume; Humans; Lung; Methacholine Chloride; Middle Aged | 1992 |
Bronchial responsiveness and work-related asthma in aluminium potroom workers: effect of removal from exposure.
Topics: Adult; Aluminum; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Eosinophils; Female; Forced Expiratory Volume; Humans; Leukocyte Count; Male; Methacholine Chloride; Occupational Diseases; Occupational Exposure | 1992 |
Development of increased airway responsiveness in two nurses performing methacholine and histamine challenge tests.
Topics: Adult; Aerosols; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Histamine; Humans; Methacholine Chloride; Nurses; Occupational Diseases; Respiratory Function Tests | 1992 |
Bronchodilator testing "confidence intervals" based on the level of bronchial responsiveness.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodilator Agents; Confidence Intervals; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Reference Values; Spirometry; Terminology as Topic; Vital Capacity | 1992 |
Distilled water challenges in asthmatic children. Comparison of different protocols.
Topics: Aerosols; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Child; Cold Temperature; Female; Humans; Male; Methacholine Chloride; Nebulizers and Vaporizers; Respiratory Function Tests; Sensitivity and Specificity; Water | 1992 |
Repeated methacholine challenge produces tolerance in normal but not in asthmatic subjects.
Topics: Adaptation, Physiological; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Drug Tolerance; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Tachyphylaxis | 1992 |
[Two cases of vocal cord dysfunction and bronchial asthma indicated contrary course of bronchial responsiveness based on astography].
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Diagnosis, Differential; Female; Humans; Laryngeal Diseases; Male; Methacholine Chloride; Vocal Cords | 1992 |
Perception of bronchoconstriction in chronic asthma.
Topics: Aerosols; Albuterol; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Perception | 1992 |
Diet in infancy and bronchial hyperreactivity later in childhood.
Topics: Age Factors; Allergens; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Humans; Hypersensitivity, Immediate; Infant; Infant Nutritional Physiological Phenomena; Methacholine Chloride; Prospective Studies; Sensitivity and Specificity; Skin Tests | 1992 |
Relationships of bronchial responsiveness assessed by methacholine to serum IgE, lung function, symptoms, and diagnoses in 11-year-old New Zealand children.
Topics: Asthma; Bronchi; Child; Female; Forced Expiratory Volume; Humans; Immunoglobulin E; Male; Methacholine Chloride; Regression Analysis; Vital Capacity | 1992 |
Prevalence of respiratory disorders among aluminium potroom workers in relation to exposure to fluoride.
Topics: Adolescent; Adult; Aged; Aluminum; Asthma; Cross-Sectional Studies; Female; Fluorides; Humans; Lung Diseases; Male; Metallurgy; Methacholine Chloride; Middle Aged; Norway; Occupational Diseases; Occupational Exposure; Prevalence; Respiratory Function Tests; Smoking | 1992 |
Longitudinal changes in bronchial hyperresponsiveness in asthmatic and previously asthmatic children.
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Humans; Immunoglobulin E; Longitudinal Studies; Methacholine Chloride; Middle Aged; Skin Tests | 1992 |
Probability of asthma based on methacholine challenge.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Bronchial Provocation Tests; Child; False Negative Reactions; False Positive Reactions; Female; Humans; Male; Methacholine Chloride; Middle Aged; Probability; Sensitivity and Specificity | 1992 |
Total circulating IgE and FEV1 in adult men. An epidemiologic longitudinal study.
Topics: Adult; Asthma; Bronchial Provocation Tests; Cross-Sectional Studies; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Longitudinal Studies; Male; Methacholine Chloride; Middle Aged; Risk Factors; Skin Tests; Smoking | 1992 |
Effect of body posture on concentration-response curves to inhaled methacholine.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Humans; Lung Volume Measurements; Male; Methacholine Chloride; Posture; Supine Position | 1992 |
Enhanced muscarinic receptor blockade with atropine in the asthmatic tracheobronchial tree. Evidence for increased drug delivery.
Topics: Adult; Asthma; Atropine; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Middle Aged; Receptors, Muscarinic; Reproducibility of Results | 1992 |
Cough threshold to inhaled tartaric acid and bronchial responsiveness to methacholine in patients with asthma and sino-bronchial syndrome.
Topics: Adult; Aged; Asthma; Bronchi; Bronchitis; Cough; Drug Resistance; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Sinusitis; Syndrome; Tartrates | 1992 |
Cough receptor sensitivity and bronchial responsiveness in normal and asthmatic subjects.
Topics: Administration, Inhalation; Adult; Aged; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cough; Female; Humans; Male; Methacholine Chloride; Middle Aged; Models, Neurological; Sensory Receptor Cells; Sensory Thresholds; Tartrates | 1992 |
A longitudinal study of baseline FEV1 and bronchial responsiveness in patients with asthma.
Topics: Adolescent; Adult; Aged; Asthma; Bronchi; Bronchial Provocation Tests; Child; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Longitudinal Studies; Male; Methacholine Chloride | 1992 |
Occupational asthma: validity of monitoring of peak expiratory flow rates and non-allergic bronchial responsiveness as compared to specific inhalation challenge.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Female; Histamine; Humans; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Peak Expiratory Flow Rate; Prospective Studies; Sensitivity and Specificity | 1992 |
Serial measurements of peak expiratory flow and responsiveness to methacholine in the diagnosis of aluminium potroom asthma.
Topics: Adult; Aluminum; Asthma; Cross-Sectional Studies; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Peak Expiratory Flow Rate | 1992 |
Effect of an inhaled thromboxane mimetic (U46619) on airway function in human subjects.
Topics: Aerosols; Asthma; Blood Pressure; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Female; Heart Rate; Humans; Male; Methacholine Chloride; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2 | 1992 |
Lack of bronchial hyperresponsiveness to methacholine and to isocapnic dry air hyperventilation in heart/lung and double-lung transplant recipients with normal lung histology. The Paris-Sud Lung Transplant Group.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Female; Heart-Lung Transplantation; Humans; Hyperventilation; Lung Transplantation; Male; Methacholine Chloride; Middle Aged | 1992 |
Lung function and bronchial responsiveness after bronchoalveolar lavage and bronchial biopsy performed without premedication in stable asthmatic subjects.
Topics: Adolescent; Adult; Asthma; Biopsy; Blood Gas Monitoring, Transcutaneous; Bronchi; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoscopy; Forced Expiratory Volume; Humans; Lung; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Premedication; Time Factors | 1992 |
Inflammatory cells and eicosanoid mediators in subjects with late asthmatic responses and increases in airway responsiveness.
Topics: Airway Resistance; Analysis of Variance; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoscopy; Cell Count; Eicosanoids; Female; Forced Expiratory Volume; Humans; Inflammation; Male; Methacholine Chloride; Skin Tests | 1992 |
Increase in airway responsiveness and effect of deep inhalation on airway caliber in allergen-induced asthma. Relationship to the late-phase response.
Topics: Administration, Inhalation; Allergens; Asthma; Bronchi; Bronchial Provocation Tests; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Methacholine Chloride; Middle Aged; Time Factors | 1992 |
Relationship between quasi-static pulmonary hysteresis and maximal airway narrowing in humans.
Topics: Adult; Asthma; Bronchoconstriction; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Muscle Contraction; Respiratory Mechanics | 1992 |
Measurement of bronchial responsiveness in young children: comparison of transcutaneous oxygen tension and functional residual capacity during induced bronchoconstriction and -dilatation.
Topics: Asthma; Blood Gas Monitoring, Transcutaneous; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Child; Child, Preschool; Functional Residual Capacity; Humans; Methacholine Chloride; Terbutaline | 1992 |
Urinary leukotriene E4 in patients with asthma. Effect of airways reactivity and sodium cromoglycate.
Topics: Adult; Asthma; Cromolyn Sodium; Forced Expiratory Volume; Humans; Leukotriene E4; Lung; Methacholine Chloride; Middle Aged; Peak Expiratory Flow Rate; Respiratory System; SRS-A; Time Factors | 1991 |
[The mechanism of airway hyperresponsiveness following immediate bronchial response in ovalbumin (OA)-sensitized guinea pigs].
Topics: Animals; Asthma; Bronchi; Bronchoconstriction; Disease Models, Animal; Guinea Pigs; Male; Methacholine Chloride; Ovalbumin; Receptors, Adrenergic, beta | 1991 |
Isocyanate-induced asthma: results of inhalation tests with TDI, MDI and methacholine.
Topics: Asthma; Bronchial Provocation Tests; Cyanates; Female; Humans; Isocyanates; Male; Methacholine Chloride; Middle Aged; Occupational Diseases; Respiratory Function Tests; Skin Tests; Toluene 2,4-Diisocyanate | 1991 |
Toluene diisocyanate-induced asthma: clinical findings and bronchial responsiveness studies in 113 exposed subjects with work-related respiratory symptoms.
Topics: Adult; Asthma; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Occupational Diseases; Spirometry; Toluene 2,4-Diisocyanate; Vital Capacity | 1991 |
Prolonged protection against methacholine-induced bronchoconstriction by the inhaled beta 2-agonist formoterol.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Ethanolamines; Female; Formoterol Fumarate; Humans; Male; Methacholine Chloride; Time Factors | 1991 |
Outcome of patients with cedar asthma with continuous exposure.
Topics: Allergens; Asthma; British Columbia; Bronchial Provocation Tests; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Lignans; Male; Methacholine Chloride; Methacholine Compounds; Naphthols; Occupational Diseases; Palliative Care; Remission Induction; Surveys and Questionnaires; Vital Capacity; Wood | 1990 |
The effect of aerosol distribution on airway responsiveness to inhaled methacholine in patients with asthma.
Topics: Administration, Inhalation; Adult; Aerosols; Asthma; Asthma, Exercise-Induced; Female; Forced Expiratory Volume; Gamma Cameras; Humans; Lung; Male; Methacholine Chloride; Particle Size; Radionuclide Imaging; Technetium Tc 99m Sulfur Colloid; Vital Capacity | 1992 |
Passive cigarette smoke-challenge studies: increase in bronchial hyperreactivity.
Topics: Adolescent; Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Female; Humans; Male; Methacholine Chloride; Respiratory Function Tests; Skin Tests; Time Factors; Tobacco Smoke Pollution | 1992 |
Near-fatal asthma: clinical and physiologic features, perception of bronchoconstriction, and psychologic profile.
Topics: Acidosis, Respiratory; Acute Disease; Adult; Aged; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Death; Female; Humans; Male; Methacholine Chloride; Middle Aged; MMPI; Patient Compliance; Peak Expiratory Flow Rate; Respiration, Artificial | 1991 |
Comparison of FEV1 and transcutaneous oxygen tension in the measurement of airway responsiveness to methacholine.
Topics: Asthma; Blood Gas Monitoring, Transcutaneous; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride | 1991 |
[The measurement of bronchial hyperreactivity for military service fitness].
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Humans; Italy; Male; Methacholine Chloride; Military Personnel; Skin Tests | 1991 |
Quantitative skin prick and bronchial provocation tests with platinum salt.
Topics: Adult; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Humans; Metallurgy; Methacholine Chloride; Middle Aged; Occupational Diseases; Occupational Exposure; Platinum; Skin Tests; Time Factors | 1991 |
Relationships of haptoglobin level to FEV1, wheezing, bronchial hyper-responsiveness and allergy.
Topics: Adult; alpha 1-Antitrypsin; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Comorbidity; Forced Expiratory Volume; Haptoglobins; Humans; Hypersensitivity; Male; Methacholine Chloride; Middle Aged; Orosomucoid; Respiratory Sounds; Smoking | 1991 |
Aspirin-induced asthma and bronchial hyperresponsiveness.
Topics: Adolescent; Adult; Airway Resistance; Angioedema; Aspirin; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchial Spasm; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Humans; Lysine; Male; Methacholine Chloride; Middle Aged; Urticaria | 1991 |
Persistent airway hyperresponsiveness after neonatal viral bronchiolitis in rats.
Topics: Airway Resistance; Animals; Animals, Newborn; Asthma; Bronchiolitis, Viral; Methacholine Chloride; Parainfluenza Virus 1, Human; Paramyxoviridae Infections; Pulmonary Gas Exchange; Rats; Rats, Inbred Strains; Respiratory Mechanics | 1991 |
Comparison of maximal airway narrowing to methacholine between children and adults.
Topics: Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Child; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride | 1991 |
A comparison of the Yan and a dosimeter method for methacholine challenge in experienced and inexperienced subjects.
Topics: Adult; Asthma; Bronchial Provocation Tests; Calibration; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Nebulizers and Vaporizers; Reproducibility of Results | 1991 |
Use of transcutaneous oxygen tension, arterial oxygen saturation, and respiratory resistance to assess the response to inhaled methacholine in asthmatic children and normal adults.
Topics: Administration, Inhalation; Adult; Asthma; Blood Gas Monitoring, Transcutaneous; Bronchoconstriction; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Middle Aged; Respiration | 1991 |
Repeatability of histamine bronchial challenge and comparability with methacholine bronchial challenge in a population of Australian schoolchildren.
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstriction; Dose-Response Relationship, Drug; Evaluation Studies as Topic; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; New South Wales; Reproducibility of Results | 1991 |
Dissimilarity in methacholine and adenosine 5'-monophosphate responsiveness 3 and 24 h after allergen challenge.
Topics: Adenosine Monophosphate; Adult; Allergens; Animals; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Dust; Female; Humans; Male; Methacholine Chloride; Mites; Time Factors | 1991 |
Late-phase asthmatic reaction to inhaled allergen is associated with early recruitment of eosinophils in the airways.
Topics: Adolescent; Adult; Allergens; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Dust; Eosinophils; Female; Humans; Male; Methacholine Chloride; Mites; Time Factors | 1991 |
Structural changes in the airways of sensitized brown Norway rats after antigen challenge.
Topics: Animals; Antigens; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Female; Lung; Male; Methacholine Chloride; Muscle, Smooth; Ovalbumin; Rats; Rats, Inbred BN | 1991 |
Outcome of assessments for occupational asthma.
Topics: Adult; Albuterol; Allergens; Asthma; Bronchial Provocation Tests; Diagnosis, Differential; Female; Forced Expiratory Volume; Humans; Irritants; Laboratories; Male; Methacholine Chloride; Occupational Diseases; Occupational Exposure; Peak Expiratory Flow Rate; Retrospective Studies; Skin Tests; Spirometry; Time Factors; Vital Capacity | 1991 |
Exercise but not methacholine differentiates asthma from chronic lung disease in children.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Child; Child, Preschool; Chronic Disease; Exercise; Exercise Test; Forced Expiratory Volume; Humans; Lung; Lung Diseases; Maximal Midexpiratory Flow Rate; Methacholine Chloride; Nebulizers and Vaporizers; Vital Capacity | 1991 |
Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children.
Topics: Asthma; Bronchi; Bronchial Provocation Tests; Child; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Sex Factors | 1991 |
Relationship between response to inhaled salbutamol and methacholine bronchial provocation in children with suspected asthma.
Topics: Administration, Inhalation; Adolescent; Albuterol; Asthma; Bronchi; Bronchial Provocation Tests; Child; Female; Humans; Male; Methacholine Chloride; Respiration | 1991 |
The ventilatory and oxygen costs in the anesthetized rhesus monkey of inhaling drugs used in the therapy and diagnosis of asthma.
Topics: Administration, Inhalation; Albuterol; Anesthesia; Animals; Asthma; Cromolyn Sodium; Epinephrine; Functional Residual Capacity; Heart Rate; Macaca mulatta; Male; Methacholine Chloride; Oxygen Consumption; Respiration; Terbutaline | 1991 |
Indices of nonspecific bronchial responsiveness in a pediatric population.
Topics: Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Cross-Sectional Studies; Female; Forced Expiratory Volume; Humans; Italy; Male; Methacholine Chloride; Prevalence; ROC Curve; Sensitivity and Specificity; Surveys and Questionnaires | 1991 |
Spontaneous changes in bronchial responsiveness in children and adolescents: an 18-month follow-up.
Topics: Adolescent; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Exercise Test; Female; Follow-Up Studies; Forced Expiratory Volume; Histamine; Humans; Immunoglobulins; Male; Methacholine Chloride; Skin Tests | 1991 |
Outbreak of the reactive airways dysfunction syndrome after a spill of glacial acetic acid.
Topics: Accidents, Occupational; Acetates; Acetic Acid; Adult; Asthma; Bronchial Provocation Tests; Disease Outbreaks; Female; Humans; Methacholine Chloride; Nuclear Medicine Department, Hospital; Occupational Diseases; Occupational Exposure; Rhode Island; Risk Factors; Surveys and Questionnaires; Syndrome | 1991 |
Comparison of airway responsiveness to prostaglandin D2 and histamine, methacholine or exercise in healthy and asthmatic subjects.
Topics: Adult; Airway Resistance; Asthma; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Physical Exertion; Prostaglandin D2; Reference Values; Rhinitis | 1991 |
Bronchoalveolar lavage (BAL) cell profiles in mild asthmatic and nonasthmatic subjects.
Topics: Adult; Asthma; Bronchoalveolar Lavage Fluid; Female; Humans; Leukocytes; Male; Methacholine Chloride; Reference Values | 1991 |
Significant changes of bronchial responsiveness to methacholine after early asthmatic reaction to toluene diisocyanate (TDI) in a TDI-sensitive asthmatic worker.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Humans; Male; Methacholine Chloride; Occupational Diseases; Skin Tests; Time Factors; Toluene 2,4-Diisocyanate | 1990 |
Bronchial responsiveness is not increased by bronchoalveolar and bronchial lavage performed after allergen challenge.
Topics: Adolescent; Adult; Allergens; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Respiratory Hypersensitivity; Rhinitis, Allergic, Perennial | 1991 |
Methotrexate-induced asthma.
Topics: Asthma; Bronchial Provocation Tests; Female; Humans; Methacholine Chloride; Methotrexate; Middle Aged | 1991 |
Bronchoalveolar lavage fluid mediator levels 5 minutes after allergen challenge in atopic subjects with asthma: relationship to the development of late asthmatic responses.
Topics: Adolescent; Adult; Allergens; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Forced Expiratory Volume; Histamine; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Methacholine Chloride; Middle Aged; Prostaglandin D2; Skin Tests; SRS-A; Thromboxane B2; Time Factors | 1991 |
Screening for occupational asthma: a word of caution.
Topics: Adult; Asthma; Bronchial Provocation Tests; Humans; Male; Methacholine Chloride; Occupational Diseases; Skin Tests | 1991 |
Site of airway hyperreactivity.
Topics: Adult; Airway Resistance; Asthma; Bronchi; Bronchoconstriction; Humans; Methacholine Chloride; Middle Aged; Respiratory Mechanics | 1991 |
The safety aspects of fiberoptic bronchoscopy, bronchoalveolar lavage, and endobronchial biopsy in asthma.
Topics: Adult; Aged; Albuterol; Asthma; Biopsy, Needle; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoscopy; Forced Expiratory Volume; Humans; Methacholine Chloride; Middle Aged; Oxyhemoglobins; Peak Expiratory Flow Rate | 1991 |
A bronchial response comparison of exercise and methacholine in asthmatic subjects.
Topics: Adult; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Bronchoconstriction; Evaluation Studies as Topic; Exercise Test; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Sensitivity and Specificity | 1991 |
Human eosinophil major basic protein induces airway constriction and airway hyperresponsiveness in primates.
Topics: Airway Resistance; Animals; Asthma; Blood Proteins; Bronchial Provocation Tests; Eosinophil Granule Proteins; Humans; Macaca fascicularis; Methacholine Chloride; Ribonucleases; Trachea | 1991 |
Analysis of factors associated with bronchial hyperreactivity to methacholine in bronchiectasis.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchiectasis; Bronchoconstriction; Female; Humans; Male; Methacholine Chloride; Middle Aged; Spirometry; Sputum | 1991 |
Evaluation of a new asthma questionnaire.
Topics: Asthma; Bronchial Provocation Tests; Bronchoconstriction; Evaluation Studies as Topic; Humans; Methacholine Chloride; Prevalence; Reproducibility of Results; Surveys and Questionnaires | 1991 |
The increased responsiveness to inhaled methacholine in asthma: combination of causative factors.
Topics: Airway Resistance; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Dose-Response Relationship, Drug; Humans; Methacholine Chloride; Muscle Contraction; Muscle, Smooth | 1991 |
Pulmonary reflexes after human heart-lung transplantation.
Topics: Aerosols; Asthma; Bronchoconstriction; Capsaicin; Cough; Denervation; Heart-Lung Transplantation; Humans; Lung; Methacholine Chloride; Reflex | 1991 |
Airway response to exercise and methacholine in children with respiratory symptoms.
Topics: Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Child; Exercise; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride | 1991 |
Methacholine responsiveness, respiratory symptoms and pulmonary function in aluminum potroom workers.
Topics: Adult; Aged; Aluminum; Asthma; Bronchial Provocation Tests; Cross-Sectional Studies; Female; Forced Expiratory Volume; Humans; Male; Metallurgy; Methacholine Chloride; Middle Aged; Occupational Diseases; Odds Ratio; Prevalence; Sensitivity and Specificity; Smoking | 1991 |
Characteristics of bronchial hyperresponsiveness in chronic obstructive pulmonary disease and in asthma.
Topics: Asthma; Bronchi; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Histamine; Humans; Lung Diseases, Obstructive; Male; Methacholine Chloride; Middle Aged; Osmosis; Peak Expiratory Flow Rate; Propranolol; Sensitivity and Specificity | 1991 |
Effect of 0.25 ppm nitrogen dioxide on the airway response to methacholine in asymptomatic asthmatic patients.
Topics: Adolescent; Adult; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoconstriction; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Nitrogen Dioxide; Vital Capacity | 1991 |
Nonspecific bronchial reactivity in asthmatic children depends on severity but not on age.
Topics: Adolescent; Age Factors; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Child; Child, Preschool; Female; Humans; Infant; Male; Methacholine Chloride | 1991 |
Ventilation-perfusion mismatch after methacholine challenge in patients with mild bronchial asthma.
Topics: Adolescent; Adult; Albuterol; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Heart Rate; Humans; Male; Maximal Midexpiratory Flow Rate; Methacholine Chloride; Middle Aged; Pulmonary Circulation; Pulmonary Gas Exchange; Time Factors; Ventilation-Perfusion Ratio | 1991 |
Allergen-induced increase in airway responsiveness and inflammation in mild asthma.
Topics: Adult; Airway Resistance; Allergens; Analysis of Variance; Asthma; Bronchi; Eosinophils; Humans; Inflammation; Lymphocytes; Male; Methacholine Chloride; Pulmonary Alveoli; Rhinitis, Allergic, Perennial; Therapeutic Irrigation | 1990 |
[The information value of bronchial provocation tests].
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Evaluation Studies as Topic; Humans; Methacholine Chloride | 1990 |
Plasticisers, another burden for asthmatics?
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Asthma; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Isoquinolines; Male; Methacholine Chloride; Piperazines; Plasticizers; Rats; Rats, Inbred Strains; Trachea | 1990 |
[Potentiating effect of spirometric maneuver on bronchial responsiveness to methacholine in asthmatic subjects--the role of deep inspiration and forced expiration].
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Bronchospirometry; Female; Forced Expiratory Flow Rates; Humans; Inhalation; Male; Methacholine Chloride; Middle Aged; Respiration | 1990 |
Continuous methacholine inhalation provocation with resistance monitoring in asthmatic patients.
Topics: Airway Resistance; Asthma; Bronchial Provocation Tests; Humans; Immunoglobulin E; Methacholine Chloride | 1990 |
Bronchial response to methacholine in "healthy" children of asthmatic parents. Effect of treatment with cromolyn sodium.
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Child; Cromolyn Sodium; Dose-Response Relationship, Drug; Female; Humans; Methacholine Chloride; Methacholine Compounds; Respiratory Function Tests | 1990 |
Neutrophil chemotactic activity in toluene diisocyanate (TDI)-induced asthma.
Topics: Animals; Asthma; Basophils; Bronchial Provocation Tests; Chemotactic Factors, Eosinophil; Chemotaxis, Leukocyte; Chromatography, Gel; Cyanates; Forced Expiratory Volume; Humans; Mast Cells; Methacholine Chloride; Methacholine Compounds; Mites; Molecular Weight; Neutrophils; Time Factors; Toluene 2,4-Diisocyanate | 1990 |
Asthmatic airways have a disproportionate hyperresponsiveness to LTE4, as compared with normal airways, but not to LTC4, LTD4, methacholine, and histamine.
Topics: Adult; Airway Resistance; Asthma; Bronchoconstriction; Dose-Response Relationship, Drug; Female; Histamine; Humans; Leukotriene E4; Leukotrienes; Male; Methacholine Chloride; SRS-A | 1990 |
Alpha- and beta-adrenergic-receptor systems in bronchial asthma and in subjects without asthma: reduced mononuclear cell beta-receptors in bronchial asthma.
Topics: Adolescent; Adult; Asthma; Blood Platelets; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Monocytes; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Reference Values; Respiratory Function Tests | 1990 |
Peripheral lung resistance in normal and asthmatic subjects.
Topics: Airway Resistance; Asthma; Bronchial Provocation Tests; Bronchoscopy; Humans; Isoproterenol; Lung; Methacholine Chloride; Methacholine Compounds; Pressure; Reference Values; Respiratory Function Tests | 1990 |
Chronic cough. The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Bronchial Provocation Tests; Child; Chronic Disease; Clinical Protocols; Cough; Esophagus; Female; Gastroesophageal Reflux; Humans; Hydrogen-Ion Concentration; Male; Medical History Taking; Methacholine Chloride; Methacholine Compounds; Middle Aged; Mucus; Nasal Mucosa; Physical Examination; Predictive Value of Tests; Prospective Studies | 1990 |
Inhalational challenge using hypertonic saline in asthmatic subjects: a comparison with responses to hyperpnoea, methacholine and water.
Topics: Adult; Aerosols; Asthma; Bronchial Provocation Tests; Child; Exercise Test; Female; Forced Expiratory Volume; Humans; Hyperventilation; Male; Methacholine Chloride; Methacholine Compounds; Saline Solution, Hypertonic; Water | 1990 |
Sensitivity and specificity of PC20 and peak expiratory flow rate in cedar asthma.
Topics: Allergens; Asthma; Bronchial Provocation Tests; False Positive Reactions; Forced Expiratory Volume; Humans; Lignans; Methacholine Chloride; Methacholine Compounds; Naphthols; Occupational Diseases; Peak Expiratory Flow Rate; Time Factors; Trees | 1990 |
Acute bronchoconstriction is not a stimulus for sympatho-adrenal activation in asthmatic or healthy subjects.
Topics: Acute Disease; Adolescent; Adult; Asthma; Bronchi; Bronchial Provocation Tests; Bronchial Spasm; Epinephrine; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Neuropeptide Y; Norepinephrine; Reference Values; Respiratory Function Tests | 1990 |
Nonwheezing bronchial asthma diagnosed by methacholine challenge.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Diagnosis, Differential; Humans; Male; Methacholine Chloride; Methacholine Compounds | 1990 |
Bronchial hyperresponsiveness in two populations of South Australian rural schoolchildren.
Topics: Asthma; Bronchial Provocation Tests; Bronchitis; Child; Cough; Cross-Sectional Studies; Female; Humans; Longitudinal Studies; Male; Methacholine Chloride; Methacholine Compounds; Prevalence; Respiratory Hypersensitivity; Respiratory Sounds; Rural Health; South Australia; Surveys and Questionnaires | 1990 |
Methacholine airway responsiveness decreases during exercise in asthmatic subjects.
Topics: Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Bronchi; Bronchial Provocation Tests; Exercise; Exercise Test; Humans; Methacholine Chloride; Methacholine Compounds; Middle Aged; Time Factors | 1990 |
Variations of airway responsiveness to methacholine and exercise in asthmatic and normal subjects over a 12-month period.
Topics: Adult; Air Pressure; Airway Resistance; Asthma; Exercise; Female; Forced Expiratory Volume; Humans; Humidity; Male; Methacholine Chloride; Methacholine Compounds; Peak Expiratory Flow Rate; Periodicity; Pollen; Reference Values; Seasons; Temperature | 1990 |
[Thromboxane A2 could be involved in bronchial hyperresponsiveness to methacholine in asthmatic subjects but not in bronchitic subjects].
Topics: Asthma; Bronchi; Bronchial Provocation Tests; Bronchitis; Chronic Disease; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Methacrylates; Middle Aged; Thromboxane A2; Thromboxane-A Synthase | 1990 |
The relationship between atopy and non-specific bronchial responsiveness.
Topics: Adolescent; Adult; Asthma; Bronchi; Bronchial Provocation Tests; Eosinophils; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Leukocyte Count; Methacholine Chloride; Methacholine Compounds | 1990 |
Pattern of airway response to allergen extract of Phleum pratensis in asthmatic patients during and outside the pollen season.
Topics: Adult; Allergens; Asthma; Bronchi; Bronchial Provocation Tests; Forced Expiratory Volume; Humans; Methacholine Chloride; Methacholine Compounds; Poaceae; Pollen; Seasons | 1990 |
Bronchodilating effect of inhaled or orally administered calcium channel blocking agents on methacholine-induced bronchoconstriction.
Topics: Administration, Inhalation; Administration, Oral; Adolescent; Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Female; Humans; Male; Metaproterenol; Methacholine Chloride; Methacholine Compounds; Middle Aged; Nifedipine; Verapamil | 1990 |
[Effect of nitrogen dioxide on exercise-induced bronchial asthma and the sensitivity of the respiratory tract to methacholine].
Topics: Adult; Air Pollutants; Airway Resistance; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Nitrogen Dioxide | 1990 |
[Measurement of airway resistance by an interrupter technique in anesthetized dogs during methacholine induced bronchoconstriction].
Topics: Airway Resistance; Animals; Asthma; Bronchi; Dogs; Female; Hemodynamics; Male; Methacholine Chloride; Methacholine Compounds | 1990 |
Mechanisms of hyperinflation in asthma.
Topics: Asthma; Bronchial Provocation Tests; Bronchial Spasm; Female; Forced Expiratory Volume; Humans; Lung; Lung Compliance; Lung Volume Measurements; Male; Methacholine Chloride; Methacholine Compounds; Respiratory Mechanics; Respiratory Muscles; Ventilators, Mechanical | 1990 |
Comparative effects of volume history on bronchoconstriction induced by hyperventilation and methacholine in asthmatic subjects.
Topics: Asthma; Bronchial Provocation Tests; Bronchial Spasm; Cold Temperature; Forced Expiratory Volume; Humans; Hyperventilation; Lung Compliance; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1990 |
Airway hyperresponsiveness. Relevance of random population data to clinical usefulness.
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Child; Histamine; Humans; Methacholine Chloride; Methacholine Compounds; Prevalence; Pulmonary Ventilation | 1990 |
Inflammatory markers in bronchoalveolar lavage and in bronchial biopsy in asthma during remission.
Topics: Adolescent; Adult; Asthma; Biopsy; Bronchi; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Count; Eosinophils; Epithelium; Female; Humans; Inflammation; Male; Mast Cells; Methacholine Chloride; Methacholine Compounds | 1990 |
Association of MS Pi phenotype with airway hyperresponsiveness.
Topics: Adolescent; Adult; alpha 1-Antitrypsin; Asthma; Bronchi; Bronchial Provocation Tests; Child; Heterozygote; Humans; Immunoglobulin E; Methacholine Chloride; Methacholine Compounds; Phenotype; Skin Tests | 1990 |
Attenuating effect of a thromboxane synthetase inhibitor (OKY-046) on bronchial responsiveness to methacholine is specific to bronchial asthma.
Topics: Acrylates; Asthma; Bronchi; Bronchial Provocation Tests; Bronchiectasis; Bronchitis; Female; Forced Expiratory Volume; Humans; Indomethacin; Male; Methacholine Chloride; Methacholine Compounds; Methacrylates; Middle Aged; Thromboxane A2; Thromboxane-A Synthase; Vital Capacity | 1990 |
Relationship between recurrent croup and airway hyperreactivity.
Topics: Asthma; Bronchi; Bronchial Provocation Tests; Child; Croup; Female; Forced Expiratory Volume; Humans; Laryngitis; Male; Methacholine Chloride; Methacholine Compounds; Recurrence; Respiratory Function Tests; Skin Tests | 1990 |
Effect of PAF-acether inhalation on nonspecific bronchial reactivity and adrenergic response in normal and asthmatic subjects.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Female; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Isoproterenol; Leukocyte Count; Male; Methacholine Chloride; Platelet Activating Factor | 1990 |
Effect of sleep and sleep deprivation on ventilatory response to bronchoconstriction.
Topics: Adult; Airway Resistance; Arousal; Asthma; Bronchi; Humans; Male; Methacholine Chloride; Respiration; Sleep; Sleep Deprivation | 1990 |
Predictive value of airway reactivity.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Child; Humans; Methacholine Chloride; Predictive Value of Tests; Respiratory System; Risk Factors | 1990 |
Circadian basis of the late asthmatic response.
Topics: Adult; Allergens; Asthma; Bronchial Provocation Tests; Circadian Rhythm; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Time Factors | 1990 |
Effect of inhaled methacholine on inspiratory flow.
Topics: Administration, Inhalation; Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Child; Child, Preschool; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Pulmonary Ventilation | 1990 |
Analysis of bronchial reactivity in epidemiological studies.
Topics: Airway Resistance; Aluminum; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Forced Expiratory Volume; Humans; Longitudinal Studies; Lung; Male; Metallurgy; Methacholine Chloride; Occupational Diseases; Reproducibility of Results | 1990 |
[Allergy and bronchial hyperreactivity in chronic obstructive lung disease].
Topics: Asthma; Bronchi; Bronchial Provocation Tests; Female; Humans; Lung Diseases, Obstructive; Male; Methacholine Chloride; Middle Aged; Respiratory Hypersensitivity; Skin Tests | 1990 |
The daily variability of bronchial responsiveness to methacholine.
Topics: Adolescent; Adult; Airway Resistance; Analysis of Variance; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Clinical Protocols; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Reproducibility of Results; Time Factors | 1990 |
Respiratory rate during acute asthma.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Bronchial Provocation Tests; Child; Exercise Test; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Peak Expiratory Flow Rate; Plethysmography; Respiration; Tidal Volume | 1990 |
The presence of airway reactivity before the development of asthma.
Topics: Adolescent; Adult; Asthma; Bronchi; Bronchial Provocation Tests; Child; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride; Methacholine Compounds; Skin Tests | 1990 |
Factors related to the nocturnal worsening of asthma.
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Circadian Rhythm; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Peak Expiratory Flow Rate; Sleep; Sodium Chloride; Theophylline | 1990 |
Assessment of airway hyperresponsiveness in chronic stable asthma.
Topics: Adult; Aged; Airway Resistance; Asthma; Bronchial Provocation Tests; Chronic Disease; Female; Humans; Irritants; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Severity of Illness Index; Surveys and Questionnaires | 1990 |
Metabisulfite oral challenge: incidence of adverse responses in chronic childhood asthma and its relationship with bronchial hyperreactivity.
Topics: Administration, Oral; Adolescent; Asthma; Bronchi; Bronchial Provocation Tests; Capsules; Child; Chronic Disease; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Solutions; Sulfites; Time Factors | 1990 |
Post-test probability of asthma following methacholine challenge.
Topics: Asthma; Bayes Theorem; Bronchial Provocation Tests; Decision Support Techniques; Decision Theory; Humans; Methacholine Chloride; Methacholine Compounds; Predictive Value of Tests; Probability; Sensitivity and Specificity; Smoking | 1990 |
Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity.
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Count; Eosinophils; Epithelium; Female; Histamine; Histamine Release; Humans; Male; Mast Cells; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1988 |
Effect of breathing pattern during inhalation challenge on the shape and position of the dose-response curve.
Topics: Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Humans; Lung Diseases, Obstructive; Lung Volume Measurements; Male; Methacholine Chloride; Methacholine Compounds | 1989 |
Comparison of responses to methacholine and cold air in patients suspected of having asthma.
Topics: Administration, Inhalation; Adult; Aerosols; Air; Asthma; Bronchial Provocation Tests; Carbon Dioxide; Cold Temperature; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Respiration | 1989 |
[Airway responsiveness to isocapnic hyperventilation with room temperature air].
Topics: Adolescent; Adult; Asthma; Bronchi; Bronchial Provocation Tests; Carbon Dioxide; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Pulmonary Ventilation; Temperature | 1989 |
Lung rejection and bronchial hyperresponsiveness to methacholine and ultrasonically nebulized distilled water in heart-lung transplantation patients.
Topics: Adult; Aerosols; Asthma; Biopsy; Bronchi; Bronchial Provocation Tests; Bronchial Spasm; Denervation; Female; Graft Rejection; Heart Transplantation; Heart-Lung Transplantation; Humans; Lung; Lung Transplantation; Male; Methacholine Chloride; Methacholine Compounds; Pulmonary Circulation; Water | 1989 |
Effect of inhaled ipratropium bromide on methacholine and exercise provocation in asthmatic children.
Topics: Administration, Inhalation; Asthma; Asthma, Exercise-Induced; Atropine Derivatives; Bronchial Provocation Tests; Child; Exercise Test; Female; Forced Expiratory Volume; Humans; Ipratropium; Male; Methacholine Chloride; Methacholine Compounds | 1989 |
Bronchial hyperreactivity and cough due to angiotensin-converting enzyme inhibitors.
Topics: Asthma; Bronchi; Bronchial Provocation Tests; Captopril; Cough; Enalapril; Female; Humans; Hypertension; Male; Maximal Expiratory Flow Rate; Methacholine Chloride; Methacholine Compounds; Middle Aged; Spirometry; Vital Capacity | 1989 |
Use of segmental airway lavage to obtain relevant mediators from the lungs of asthmatic and control subjects.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoscopes; Bronchoscopy; Catheterization; Histamine; Humans; Leukotriene B4; Methacholine Chloride; Methacholine Compounds; Middle Aged; Prostaglandin D2; Rhinitis, Allergic, Seasonal; Therapeutic Irrigation | 1989 |
Superoxide generation and its modulation by adenosine in the neutrophils of subjects with asthma.
Topics: Adenosine; Administration, Inhalation; Adolescent; Adult; Asthma; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Superoxides | 1989 |
The effect of an increase in inhaled allergen dose after rimiterol hydrobromide on the occurrence and magnitude of the late asthmatic response and the associated change in nonspecific bronchial responsiveness.
Topics: Adult; Aged; Allergens; Asthma; Bronchi; Bronchial Provocation Tests; Catechols; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Piperidines; Spirometry; Time Factors | 1989 |
Effect of bronchial challenge on breathing patterns and arterial oxygenation in stable asthma.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Oxygen; Respiration | 1989 |
The MVV/FEV1 ratio in normal and asthmatic subjects.
Topics: Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Maximal Voluntary Ventilation; Methacholine Chloride; Methacholine Compounds; Prospective Studies; Pulmonary Ventilation; Spirometry | 1989 |
A protocol for performing reproducible methacholine inhalation tests in children with moderate to severe asthma.
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Child; Forced Expiratory Volume; Humans; Methacholine Chloride; Methacholine Compounds; Reproducibility of Results; Theophylline | 1989 |
Significant changes in nonspecific bronchial responsiveness after isolated immediate bronchospecific reactions caused by isocyanates but not after a late reaction caused by plicatic acid.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Cyanates; Forced Expiratory Volume; Histamine; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Isocyanates; Lignans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Naphthols; Occupational Diseases | 1989 |
Spectrum of prostanoid release after bronchoalveolar allergen challenge in atopic asthmatics and in control groups. An alteration in the ratio of bronchoconstrictive to bronchoprotective mediators.
Topics: Adolescent; Adult; Allergens; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Histamine; Humans; Hypersensitivity, Immediate; Methacholine Chloride; Methacholine Compounds; Middle Aged; Prostaglandins; Skin Tests | 1989 |
Role of inhalation challenge testing in the diagnosis of isocyanate-induced asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Cyanates; Female; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Isomerism; Male; Methacholine Chloride; Methacholine Compounds; Occupational Diseases; Vital Capacity | 1989 |
Relationship between deposition of and responsiveness to inhaled methacholine in normal and asymptomatic subjects.
Topics: Administration, Inhalation; Adult; Aerosols; Asthma; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Reproducibility of Results | 1989 |
Wheezing on maximal forced exhalation in the diagnosis of atypical asthma. Lack of sensitivity and specificity.
Topics: Adult; Asthma; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Prospective Studies; Respiration; Respiratory Function Tests; Respiratory Sounds; Sensitivity and Specificity; Spirometry | 1989 |
Comparison of intermittent and continuous inhalation provocation tests.
Topics: Adult; Aerosols; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds | 1989 |
Effects of platelet activating factor on airway calibre, airway responsiveness, and circulating cells in asthmatic subjects.
Topics: Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Female; Humans; Isoproterenol; Leukocyte Count; Male; Methacholine Chloride; Methacholine Compounds; Platelet Activating Factor | 1989 |
Effects of lung volume, volume history, and methacholine on lung tissue viscance.
Topics: Adult; Airway Resistance; Asthma; Dose-Response Relationship, Drug; Female; Humans; Lung; Lung Volume Measurements; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1989 |
[Effect of spirometric maneuver on methacholine provocation test in asthmatic patients and normal subjects].
Topics: Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds | 1989 |
Reversibility of induced bronchoconstriction by deep inspiration in asthmatic and normal subjects.
Topics: Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Female; Humans; Lung Volume Measurements; Male; Maximal Voluntary Ventilation; Methacholine Chloride; Methacholine Compounds; Peak Expiratory Flow Rate; Pulmonary Ventilation | 1989 |
Symptoms of asthma, methacholine airway responsiveness and atopy in migrant Tokelauan children.
Topics: Adolescent; Asthma; Bronchi; Bronchial Provocation Tests; Child; Child, Preschool; Cross-Sectional Studies; Ethnicity; Female; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride; Methacholine Compounds; New Zealand; Transients and Migrants | 1989 |
Effect of short esophageal acidification on airway hyperreactivity.
Topics: Administration, Inhalation; Adult; Asthma; Bronchial Spasm; Esophagus; Female; Humans; Hydrogen-Ion Concentration; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1989 |
Irritant-induced occupational asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Cross-Sectional Studies; Humans; Irritants; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Occupational Diseases; Ontario; Retrospective Studies; Time Factors | 1989 |
Bronchoprovocation studies in basidiospore-sensitive allergic subjects with asthma.
Topics: Allergens; Asthma; Basidiomycota; Bronchial Provocation Tests; Dose-Response Relationship, Immunologic; Forced Expiratory Volume; Humans; Immunoglobulin E; Methacholine Chloride; Methacholine Compounds; Radioallergosorbent Test; Respiratory Hypersensitivity; Skin Tests; Spores, Fungal; Time Factors | 1989 |
Nonspecific bronchial reactivity and its relationship to the clinical expression of asthma. A longitudinal study.
Topics: Adolescent; Adult; Aged; Asthma; Bronchi; Bronchial Provocation Tests; Child; Female; Forced Expiratory Volume; Humans; Longitudinal Studies; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Peak Expiratory Flow Rate | 1989 |
[The measurement of airway responsive index in normal individuals and asthmatic patients].
Topics: Adult; Airway Resistance; Asthma; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds | 1989 |
Associations between respiratory symptoms, bronchial response to methacholine, and atopy in two age groups of schoolchildren.
Topics: Asthma; Bronchi; Bronchial Provocation Tests; Child; Female; Humans; Hypersensitivity, Immediate; Intradermal Tests; Male; Methacholine Chloride; Methacholine Compounds; Respiratory Hypersensitivity; Respiratory Sounds | 1989 |
Differences between bronchial response in children and adults with asthma to ultrasonically nebulized distilled water and methacholine.
Topics: Adolescent; Adult; Age Factors; Asthma; Bronchial Provocation Tests; Child; Humans; Methacholine Chloride; Methacholine Compounds; Middle Aged; Nebulizers and Vaporizers; Water | 1989 |
Hypnotic susceptibility and its relationship to outcome in the behavioral treatment of asthma: some preliminary data.
Topics: Adult; Aged; Asthma; Behavior Therapy; Female; Humans; Hypnosis; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1989 |
Improvement in airway responsiveness and asthma severity during pregnancy. A prospective study.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Estriol; Female; Forced Expiratory Volume; Gastroesophageal Reflux; Humans; Methacholine Chloride; Methacholine Compounds; Pregnancy; Pregnancy Complications; Progesterone; Prospective Studies; Random Allocation; Respiratory Mechanics; Vital Capacity | 1989 |
Effect of platelet-activating factor inhalation on nonspecific bronchial reactivity in man.
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Platelet Activating Factor; Time Factors | 1989 |
A comparison of three measures of the response to inhaled methacholine.
Topics: Adult; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Pulmonary Ventilation; Reproducibility of Results; Vital Capacity | 1989 |
Occupational asthma in a pulmonary functions laboratory.
Topics: Asthma; Humans; Methacholine Chloride; Methacholine Compounds; Occupational Diseases | 1989 |
Laryngeal resistance immediately after panting in asthmatic subjects.
Topics: Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Female; Humans; Larynx; Male; Methacholine Chloride; Methacholine Compounds | 1989 |
[Correlation of "nonspecific" hyper-reactivity of the airways with central and peripheral disorders of lung function].
Topics: Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Flour; Histamine; Humans; Lung Volume Measurements; Methacholine Chloride; Methacholine Compounds; Occupational Diseases; Plethysmography, Whole Body; Respiratory Hypersensitivity | 1989 |
Tracheobronchial clearance in asthma-discordant monozygotic twins.
Topics: Administration, Inhalation; Adult; Airway Resistance; Asthma; Bronchi; Diseases in Twins; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Mucociliary Clearance; Polytetrafluoroethylene; Radionuclide Imaging; Technetium; Trachea; Twins; Twins, Monozygotic; Vital Capacity | 1989 |
Normal airway responsiveness to methacholine in cardiac asthma.
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Diagnosis, Differential; Dyspnea, Paroxysmal; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1989 |
The influence of aerosol retention and pattern of deposition on bronchial responsiveness to atropine and methacholine in humans.
Topics: Adult; Aerosols; Airway Resistance; Asthma; Atropine; Bronchi; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Lung; Male; Methacholine Chloride; Methacholine Compounds; Radionuclide Imaging; Technetium | 1989 |
Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity.
Topics: Adult; Asthma; Basement Membrane; Biopsy; Bronchi; Bronchoscopy; Epithelium; Female; Humans; Inflammation; Male; Methacholine Chloride; Methacholine Compounds | 1989 |
Methacholine inhalation challenge in the diagnosis of asthma.
Topics: Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Humans; Methacholine Chloride; Methacholine Compounds | 1989 |
Housewives with raw potato-induced bronchial asthma.
Topics: Adult; Antibodies; Asthma; Bronchial Provocation Tests; Conjunctivitis; Female; Forced Expiratory Volume; Humans; Immunoglobulin E; Methacholine Chloride; Methacholine Compounds; Middle Aged; Rhinitis; Skin Tests; Solanum tuberosum | 1989 |
Relationship between anti-IgE autoantibody and severity of bronchial asthma.
Topics: Antibodies, Anti-Idiotypic; Asthma; Autoantibodies; Bronchial Provocation Tests; Humans; Immunoglobulin E; Methacholine Chloride; Methacholine Compounds | 1989 |
[Airway responsiveness measured by body plethysmograph connecting a circuit of an inhalation system of serially concentrated bronchoconstrictant].
Topics: Acetylcholine; Administration, Inhalation; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Child; Humans; Lung Diseases, Obstructive; Methacholine Chloride; Methacholine Compounds; Nebulizers and Vaporizers; Plethysmography, Whole Body | 1989 |
Differentiation in dose-response curves of airway responsiveness to inhaled methacholine between asthmatics and nonasthmatics.
Topics: Adolescent; Adult; Aerosols; Airway Resistance; Asthma; Differential Threshold; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Middle Aged; Reference Values; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 1989 |
Importance of airway inflammation for late asthmatic reactions induced by toluene diisocyanate in sensitized subjects.
Topics: Adult; Asthma; Cyanates; Humans; Inflammation; Male; Methacholine Chloride; Methacholine Compounds; Respiratory System; Time Factors; Toluene 2,4-Diisocyanate | 1987 |
Recurrent asthma induced by toluene diisocyanate.
Topics: Adult; Asthma; Chemical Industry; Cyanates; Humans; Male; Methacholine Chloride; Methacholine Compounds; Occupational Diseases; Recurrence; Toluene 2,4-Diisocyanate | 1988 |
Persistent asthma due to isocyanates. A follow-up study of subjects with occupational asthma due to toluene diisocyanate (TDI).
Topics: Asthma; Bronchial Provocation Tests; Chronic Disease; Cyanates; Environmental Exposure; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Toluene 2,4-Diisocyanate | 1988 |
Enhanced generation of leukotriene B4 by neutrophils stimulated by unopsonized zymosan and by calcium ionophore after exercise-induced asthma.
Topics: Adolescent; Adult; Airway Resistance; Arachidonate 5-Lipoxygenase; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Calcimycin; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Neutrophils; Stereoisomerism; Zymosan | 1988 |
The relative responsiveness to inhaled leukotriene E4, methacholine and histamine in normal and asthmatic subjects.
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Bronchi; Female; Histamine; Humans; Leukotriene E4; Male; Methacholine Chloride; Methacholine Compounds; SRS-A | 1988 |
Relationship between bronchial airway responsiveness and clinical severity of asthma.
Topics: Adult; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Bronchodilator Agents; Cold Temperature; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Predictive Value of Tests | 1988 |
Chemical properties of bronchorrhea sputum in bronchial asthma.
Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Asthma; Bronchial Provocation Tests; Female; Glucocorticoids; Histamine H1 Antagonists; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Mucus; Saliva; Sputum; Water | 1988 |
Cholinergic-mediated bronchoconstriction induced by prostaglandin D2, its initial metabolite 9 alpha,11 beta-PGF2, and PGF2 alpha in asthma.
Topics: Adult; Airway Resistance; Asthma; Bronchi; Dinoprost; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Ipratropium; Male; Methacholine Chloride; Methacholine Compounds; Parasympathetic Nervous System; Prostaglandin D2; Prostaglandins; Prostaglandins D; Prostaglandins F | 1987 |
Lack of correlation between the grade of methacholine-induced bronchial hyperreactivity and ipratropium bronchodilation in asthmatics.
Topics: Adult; Asthma; Atropine Derivatives; Bronchi; Bronchodilator Agents; Dose-Response Relationship, Drug; Female; Humans; Ipratropium; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Respiratory Function Tests | 1988 |
Combined asthma and alveolitis due to diphenylmethane diisocyanate (MDI) with demonstration of no crossed respiratory reactivity to toluene diisocyanate (TDI).
Topics: Adult; Alveolitis, Extrinsic Allergic; Asthma; Bronchi; Bronchial Provocation Tests; Cyanates; Female; Forced Expiratory Volume; Humans; Isocyanates; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Neutrophils; Therapeutic Irrigation; Toluene 2,4-Diisocyanate | 1985 |
Adenosine-induced bronchoconstriction in asthma. Role of parasympathetic stimulation and adrenergic inhibition.
Topics: Adenosine; Adult; Asthma; Bronchi; Bronchial Provocation Tests; Constriction, Pathologic; Female; Histamine; Histamine Antagonists; Humans; Ipratropium; Isoproterenol; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Receptors, Adrenergic, beta; Respiratory Function Tests; Vagus Nerve | 1985 |
[Measurement of bronchial reactivity in asthmatics. III. Relation between bronchial reactivity to methacholine and plasma cyclic nucleotide monophosphate in asthmatic subjects].
Topics: Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Cyclic AMP; Cyclic GMP; Epinephrine; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1985 |
Prednisone inhibits late asthmatic reactions and the associated increase in airway responsiveness induced by toluene-diisocyanate in sensitized subjects.
Topics: Adult; Asthma; Cyanates; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Prednisone; Respiratory System; Toluene 2,4-Diisocyanate | 1985 |
Toluene diisocyanate-induced asthma without airway hyperresponsiveness.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Cyanates; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Occupational Diseases; Toluene 2,4-Diisocyanate | 1986 |
Beta-adrenergic responses in drug-free subjects with asthma.
Topics: Adult; Asthma; Female; Forced Expiratory Volume; Granulocytes; Heart Rate; Humans; Isoproterenol; Lymphocytes; Male; Methacholine Chloride; Methacholine Compounds; Receptors, Adrenergic, beta | 1986 |
Persistent airways disease caused by toluene diisocyanate.
Topics: Asthma; Bronchial Provocation Tests; Cyanates; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Occupational Diseases; Time Factors; Toluene 2,4-Diisocyanate | 1986 |
Adenosine-induced bronchoconstriction: premedication with chlorpheniramine and nedocromil sodium.
Topics: Adenosine; Adolescent; Adult; Asthma; Bronchial Provocation Tests; Chlorpheniramine; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Nedocromil; Quinolines | 1986 |
Specific bronchial reactivity to toluene diisocyanate: dose-response relationship.
Topics: Asthma; Bronchi; Bronchial Provocation Tests; Cyanates; Differential Threshold; Dose-Response Relationship, Drug; Forced Expiratory Volume; Humans; Methacholine Chloride; Methacholine Compounds; Toluene 2,4-Diisocyanate | 1986 |
Late, but not early, asthmatic reactions induced by toluene-diisocyanate are associated with increased airway responsiveness to methacholine.
Topics: Adult; Asthma; Bronchial Provocation Tests; Cyanates; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Occupational Diseases; Time Factors; Toluene 2,4-Diisocyanate | 1986 |
Effect of nedocromil sodium on adenosine- and methacholine-induced bronchospasm in asthma.
Topics: Adenosine; Adult; Asthma; Bronchial Spasm; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Nedocromil; Quinolines | 1987 |
Bronchoalveolar neutrophilia during late asthmatic reactions induced by toluene diisocyanate.
Topics: Asthma; Bronchi; Bronchial Provocation Tests; Cyanates; Dose-Response Relationship, Drug; Eosinophils; Forced Expiratory Volume; Humans; Leukocyte Count; Methacholine Chloride; Methacholine Compounds; Neutrophils; Pulmonary Alveoli; Therapeutic Irrigation; Time Factors; Toluene 2,4-Diisocyanate | 1987 |
Fate of grainhandlers with bronchial hyperreactivity.
Topics: Adult; Agricultural Workers' Diseases; Asthma; Dust; Edible Grain; Forced Expiratory Flow Rates; Humans; Methacholine Chloride; Methacholine Compounds; Middle Aged; Smoking | 1988 |
Airway reactivity to methacholine in nonatopic asymptomatic adults.
Topics: Adult; Asthma; Forced Expiratory Volume; Humans; Lung Volume Measurements; Methacholine Chloride; Methacholine Compounds; Reference Values; Vital Capacity | 1988 |
Bronchial reactivity pattern in nonasthmatic parents of asthmatics.
Topics: Asthma; Bronchi; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Parents | 1988 |
Comparison of cellular and protein changes in bronchial lavage fluid of symptomatic and asymptomatic patients with red cedar asthma on follow-up examination.
Topics: Adult; Aged; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Count; Follow-Up Studies; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Occupational Diseases; Proteins; Wood | 1988 |
Antigen challenge of sensitized rats increases airway responsiveness to methacholine.
Topics: Airway Resistance; Animals; Antigens; Asthma; Immunization; Male; Methacholine Chloride; Methacholine Compounds; Ovalbumin; Rats; Rats, Inbred BN | 1988 |
Comparison of maximal bronchoconstriction in vivo and airway smooth muscle responses in vitro in nonasthmatic humans.
Topics: Adult; Aged; Asthma; Bronchi; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; In Vitro Techniques; Isoproterenol; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth | 1988 |
Childhood asthma and adult lung function.
Topics: Adult; Aging; Asthma; Child; Female; Humans; Longitudinal Studies; Lung; Lung Diseases, Obstructive; Male; Methacholine Chloride; Methacholine Compounds; Prospective Studies; Respiratory Function Tests; Smoking | 1988 |
Mild isocapnic hypoxia enhances the bronchial response to methacholine in asthmatic subjects.
Topics: Adult; Asthma; Bronchi; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Hypoxia; Lung; Lung Compliance; Male; Methacholine Chloride; Methacholine Compounds | 1988 |
Leukocyte count and bronchial hyperresponsiveness.
Topics: Adult; Asthma; Bronchial Provocation Tests; Common Cold; Humans; Hypersensitivity, Immediate; Leukocyte Count; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Respiratory Hypersensitivity; Risk Factors; Smoking | 1988 |
[A study of bronchial sensitivity and bronchial reactivity using Astograph and transcutaneous oxygen tension in asthmatic children].
Topics: Adolescent; Adult; Airway Resistance; Asthma; Blood Gas Monitoring, Transcutaneous; Bronchi; Bronchial Provocation Tests; Child; Humans; Methacholine Chloride; Methacholine Compounds | 1988 |
Methacholine bronchial challenge using a dosimeter with controlled tidal breathing.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Nebulizers and Vaporizers | 1988 |
Influence of airway calibre on the intrapulmonary dose and distribution of inhaled aerosol in normal and asthmatic subjects.
Topics: Administration, Inhalation; Adult; Aerosols; Albuterol; Asthma; Female; Humans; Lung; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Nebulizers and Vaporizers; Radionuclide Imaging | 1988 |
Evaluation of bronchial responsiveness by pharmacological challenges in asthma. Inhaled propranolol in comparison with histamine and methacholine.
Topics: Adolescent; Adult; Asthma; Bronchi; Bronchial Provocation Tests; Child; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Propranolol | 1988 |
A computer-based method for on-line acquisition and analysis of bronchial challenge test.
Topics: Asthma; Bronchial Provocation Tests; Diagnosis, Computer-Assisted; Forced Expiratory Volume; Humans; Methacholine Chloride; Methacholine Compounds; Software; Vital Capacity | 1988 |
[Bronchial hyperresponsiveness in aspirin induced asthma].
Topics: Adult; Aged; Aspirin; Asthma; Bronchial Provocation Tests; Dinoprost; Female; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; SRS-A | 1988 |
Bronchoconstriction induced by distilled water. Sensitivity in asthmatics and relationship to exercise-induced bronchospasm.
Topics: Aerosols; Asthma; Asthma, Exercise-Induced; Bronchi; Cromolyn Sodium; Forced Expiratory Volume; Heart Rate; Humans; Methacholine Chloride; Methacholine Compounds; Water | 1986 |
Effects of aging on airway hyperreactivity in normal persons.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Child; Female; Humans; Lung; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1986 |
Rebound hyperresponsiveness to muscarinic stimulation after chronic therapy with an inhaled muscarinic antagonist.
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Ipratropium; Male; Methacholine Chloride; Methacholine Compounds; Muscle, Smooth; Receptors, Muscarinic; Vital Capacity | 1985 |
Distribution of bronchial nonspecific reactivity in the general population.
Topics: Acute Disease; Adolescent; Adult; Aged; Asthma; Bronchi; Bronchial Provocation Tests; Bronchitis; Chronic Disease; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Smoking | 1988 |
The effect of bronchoalveolar lavage on bronchial responsiveness in patients with airflow obstruction.
Topics: Adolescent; Adult; Aged; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Forced Expiratory Volume; Humans; Lung Diseases, Obstructive; Methacholine Chloride; Methacholine Compounds; Middle Aged; Pulmonary Emphysema; Pulmonary Ventilation | 1988 |
An open study of auranofin in the treatment of steroid-dependent asthma.
Topics: Adult; Asthma; Auranofin; Female; Gastrointestinal Diseases; Humans; Immunity, Cellular; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Prednisone; Respiratory Function Tests; Skin Diseases | 1988 |
A longitudinal study of the occurrence of bronchial hyperresponsiveness in western red cedar workers.
Topics: Allergens; Asthma; British Columbia; Bronchial Diseases; Bronchial Provocation Tests; Humans; Hypersensitivity, Immediate; Lignans; Longitudinal Studies; Male; Methacholine Chloride; Methacholine Compounds; Naphthols; Occupational Diseases; Wood | 1988 |
Bronchial provocation tests in young children using tracheal auscultation.
Topics: Adolescent; Asthma; Auscultation; Bronchial Provocation Tests; Child; Child, Preschool; Forced Expiratory Volume; Humans; Infant; Methacholine Chloride; Methacholine Compounds; Respiratory Sounds; Respiratory Tract Diseases; Spirometry; Trachea | 1988 |
Usefulness and safety of pharmacologic bronchoprovocation challenge in evaluating patients with normal spirometric tests who are suspected of having asthma.
Topics: Asthma; Bronchial Provocation Tests; Bronchial Spasm; Histamine; Humans; Methacholine Chloride; Methacholine Compounds; Spirometry | 1988 |
An assessment of methacholine inhalation tests in elderly asthmatics.
Topics: Aged; Aged, 80 and over; Albuterol; Asthma; Beclomethasone; Bronchial Provocation Tests; Dizziness; Fatigue; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Peak Expiratory Flow Rate | 1988 |
Effect of cold air exposure and exercise on nonspecific bronchial reactivity.
Topics: Adult; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Cold Temperature; Female; Humans; Lung Volume Measurements; Male; Methacholine Chloride; Methacholine Compounds; Physical Exertion | 1988 |
Effect of exercise on nonspecific airway reactivity in asthmatics.
Topics: Adult; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Physical Exertion; Respiratory Function Tests; Respiratory System | 1988 |
Bronchoconstrictor and antibronchoconstrictor properties of inhaled prostacyclin in asthma.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Asthma; Epoprostenol; Forced Expiratory Volume; Humans; Male; Maximal Expiratory Flow Rate; Methacholine Chloride; Methacholine Compounds; Prostaglandin D2; Prostaglandins D; Respiration; Vital Capacity | 1988 |
Non-pharmacological modulators of airway responsiveness.
Topics: Acetylcholine; Aerosols; Airway Resistance; Animals; Asthma; Bronchial Spasm; Humans; Methacholine Chloride; Methacholine Compounds; Muscle Contraction; Muscle, Smooth; Nicotiana; Plants, Toxic; Pulmonary Ventilation; Smoke | 1988 |
Occupational asthma due to isocyanates.
Topics: Adult; Asthma; Bronchial Provocation Tests; Cyanates; Female; Humans; Immunoglobulin E; Lung Volume Measurements; Male; Methacholine Chloride; Methacholine Compounds; Occupational Diseases | 1988 |
Methacholine for diagnosis of asthma.
Topics: Asthma; Bronchial Provocation Tests; False Negative Reactions; False Positive Reactions; Humans; Methacholine Chloride; Methacholine Compounds | 1987 |
Clinical characteristics and methacholine sensitivity in patients with suspected bronchial asthma.
Topics: Asthma; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Respiratory Hypersensitivity; Retrospective Studies | 1987 |
[Fall of the respiratory resistance curve in the inhalation test with methacholine using the Astograph in spite of bronchial constriction].
Topics: Adolescent; Airway Resistance; Asthma; Bronchial Provocation Tests; Child; Humans; Methacholine Chloride; Methacholine Compounds; Pulmonary Ventilation | 1987 |
Epidemiological diagnosis of asthma: methodological considerations of prevalence evaluation.
Topics: Adolescent; Adult; Aged; Allergens; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Sensitivity and Specificity; Skin Tests; Surveys and Questionnaires | 1987 |
Inhalation methods for the study of airway responsiveness.
Topics: Airway Obstruction; Allergens; Asthma; Bronchial Provocation Tests; Cold Temperature; Histamine; Humans; Lung Volume Measurements; Methacholine Chloride; Methacholine Compounds; Physical Exertion; Predictive Value of Tests; Respiratory Function Tests; Respiratory Hypersensitivity | 1987 |
Bronchoalveolar cell profiles of asthmatic and nonasthmatic subjects.
Topics: Asthma; Blood Proteins; Bronchi; Bronchial Provocation Tests; Cell Count; Eosinophil Granule Proteins; Forced Expiratory Volume; Humans; Methacholine Chloride; Methacholine Compounds; Pulmonary Alveoli; Ribonucleases; Vital Capacity | 1987 |
[Bronchial hyperreactivity to methacholine in workers in an aluminum electrolysis potroom].
Topics: Aluminum; Asthma; Bronchial Provocation Tests; Electrolysis; Humans; Metallurgy; Methacholine Chloride; Methacholine Compounds; Occupational Diseases | 1986 |
Pattern of specific airway response in asthma due to western red cedar (Thuja plicata): relationship with length of exposure and lung function measurements.
Topics: Adult; Allergens; Asthma; Bronchial Provocation Tests; Humans; Immunoglobulin E; Lignans; Methacholine Chloride; Methacholine Compounds; Middle Aged; Naphthols; Occupational Diseases; Respiratory Function Tests; Skin Tests; Time Factors; Wood | 1987 |
Provocative dose and dose-response curve to inhaled propranolol in asthmatic patients with bronchial hyperresponsiveness to methacholine.
Topics: Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Propranolol | 1987 |
In vitro responses of airways from an asthmatic patient.
Topics: Adult; Asthma; Bronchi; Electric Stimulation; Histamine; Humans; In Vitro Techniques; Male; Methacholine Chloride; Methacholine Compounds; Muscle Contraction; Parasympatholytics; Solitary Pulmonary Nodule; SRS-A | 1987 |
Grading severity and treatment requirements to control symptoms in asthmatic children and their relationship with airway hyperreactivity to methacholine.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds | 1987 |
[The evaluation of bronchial hyperresponsiveness in children with asthma--the significance of the parameters measured by methacholine inhalation challenge].
Topics: Adolescent; Age Factors; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Child; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Radioallergosorbent Test | 1987 |
The bronchoconstrictor properties of platelet-activating factor in humans.
Topics: Adolescent; Adult; Aerosols; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Female; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Platelet Activating Factor; Tachyphylaxis | 1987 |
Theophylline has a dose-related effect on the airway response to inhaled histamine and methacholine in asthmatics.
Topics: Adolescent; Adult; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Histamine Antagonists; Humans; Male; Methacholine Chloride; Methacholine Compounds; Theophylline | 1987 |
Prevalence and characteristics of late asthmatic responses to exercise.
Topics: Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Chemotaxis, Leukocyte; Exercise Test; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Neutrophils; Time Factors | 1987 |
The role of suggestion in asthma. I. Effects of inactive solution on bronchial reactivity under bronchoconstrictor or bronchodilator suggestion.
Topics: Administration, Inhalation; Asthma; Bronchi; Bronchial Provocation Tests; Bronchodilator Agents; Chronic Disease; Forced Expiratory Volume; Humans; Methacholine Chloride; Methacholine Compounds; Nebulizers and Vaporizers; Sodium Chloride; Suggestion | 1987 |
The role of suggestion in asthma. II. Effects of a bronchoconstrictor drug on bronchial reactivity under bronchoconstrictor or bronchodilator suggestion.
Topics: Adolescent; Adult; Asthma; Bronchi; Bronchial Provocation Tests; Bronchodilator Agents; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Suggestion | 1987 |
Shape of the dose-response curve to cold air inhalation in normal and asthmatic subjects.
Topics: Adult; Air; Asthma; Bronchial Provocation Tests; Cold Temperature; Dose-Response Relationship, Drug; Forced Expiratory Volume; Humans; Maximal Midexpiratory Flow Rate; Methacholine Chloride; Methacholine Compounds; Reference Values; Respiration; Vital Capacity | 1987 |
Analysis of dose-response curves to methacholine. An approach suitable for population studies.
Topics: Aging; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Forced Expiratory Volume; Humans; Longitudinal Studies; Lung; Male; Methacholine Chloride; Methacholine Compounds; Reference Values | 1987 |
Effect of a previous voluntary deep breath on laryngeal resistance in normal and asthmatic subjects.
Topics: Adult; Airway Resistance; Asthma; Female; Humans; Larynx; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Plethysmography, Whole Body; Respiration; Sound | 1987 |
Interpretation of the results of methacholine inhalation challenge tests.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 1987 |
Airway response to methacholine during exercise induced refractoriness in asthma.
Topics: Airway Resistance; Asthma; Asthma, Exercise-Induced; Humans; Lung; Methacholine Chloride; Methacholine Compounds | 1987 |
Plasma histamine after methacholine, allergen, and aspirin challenges.
Topics: Adult; Antigens; Aspirin; Asthma; Female; Histamine; Humans; Hypersensitivity, Immediate; Lignans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Naphthols; Respiratory Function Tests; Triticum | 1987 |
[The use of methacholine challenge testing in the evaluation of chronic cough in adults].
Topics: Adult; Asthma; Bronchial Provocation Tests; Chronic Disease; Cough; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1987 |
[Bronchial hyperreactivity in asthma at high risk of sudden death].
Topics: Adult; Asthma; Bronchial Provocation Tests; Death, Sudden; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Risk Factors; Status Asthmaticus | 1987 |
Effect of corticosteroids on bronchial responsiveness to methacholine in asthmatic children.
Topics: Adrenal Cortex Hormones; Asthma; Bronchi; Child; Humans; Methacholine Chloride; Methacholine Compounds | 1986 |
Prostaglandin D2 potentiates airway responsiveness to histamine and methacholine.
Topics: Adult; Airway Resistance; Asthma; Bradykinin; Bronchi; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Drug Synergism; Female; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Prostaglandin D2; Prostaglandins D | 1986 |
Sensitivity of methacholine testing in occupational asthma.
Topics: Asthma; Humans; Methacholine Chloride; Methacholine Compounds; Occupational Diseases | 1986 |
Absence of hyperresponsiveness to methacholine in a worker with methylene diphenyl diisocyanate (MDI)-induced asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Cyanates; False Negative Reactions; Forced Expiratory Volume; Humans; Isocyanates; Male; Methacholine Chloride; Methacholine Compounds; Occupational Diseases; Time Factors; Vital Capacity | 1986 |
Experience with methacholine inhalation challenge in the evaluation of chest symptoms.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds | 1986 |
Epidemiological research in asthma: the need for a broad perspective.
Topics: Africa; Age Factors; Asia; Asthma; Cross-Sectional Studies; England; Epidemiologic Methods; Europe; Histamine; Humans; Methacholine Chloride; Methacholine Compounds; North America; Rural Population; Urban Population | 1986 |
Bronchoalveolar lavage of allergic asthmatic patients following allergen bronchoprovocation.
Topics: Adolescent; Adult; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Eosinophils; Female; Forced Expiratory Volume; Humans; Lung; Male; Mast Cells; Methacholine Chloride; Methacholine Compounds; Microscopy, Electron; Middle Aged; Neutrophils; Therapeutic Irrigation | 1986 |
Comparison of drug responses in vivo and in vitro in airways of dogs with and without airway hyperresponsiveness.
Topics: Aerosols; Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Disease Models, Animal; Dogs; Histamine; In Vitro Techniques; Isoproterenol; Methacholine Chloride; Methacholine Compounds; Muscle Contraction; Muscle, Smooth | 1986 |
Airway responses to methacholine and histamine in basenji greyhounds and other purebred dogs.
Topics: Aerosols; Airway Resistance; Animal Husbandry; Animals; Asthma; Bronchial Provocation Tests; Dogs; Female; Histamine; Lung; Lung Compliance; Male; Methacholine Chloride; Methacholine Compounds; Respiratory Hypersensitivity | 1986 |
Dose-response effects of methacholine in normal and in asthmatic subjects. Relationship between the site of airway response and overall airway hyperresponsiveness.
Topics: Adult; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Pregnancy; Reference Values; Respiratory Dead Space; Respiratory Function Tests | 1986 |
Factors that contribute to inhibition of methacholine-induced bronchoconstriction.
Topics: Adult; Asthma; Bronchi; Bronchial Spasm; Female; Humans; Isoproterenol; Male; Methacholine Chloride; Methacholine Compounds | 1986 |
Prevalence of bronchial hyperresponsiveness in highly trained athletes.
Topics: Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Bronchi; Bronchial Provocation Tests; Football; Humans; Male; Methacholine Chloride; Methacholine Compounds; Sports; Students, Medical; Surveys and Questionnaires | 1986 |
[Bronchial hyperreactivity. Methods of detection with pharmacologic substances].
Topics: Acetylcholine; Airway Obstruction; Asthma; Bronchial Provocation Tests; Carbachol; Histamine; Humans; Methacholine Chloride; Methacholine Compounds; Respiratory Hypersensitivity | 1986 |
Airway responsiveness to leukotrienes C4 and D4 and to methacholine in patients with asthma and normal controls.
Topics: Adult; Aerosols; Asthma; Bronchi; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Pulmonary Ventilation; SRS-A | 1986 |
Bronchial challenge: interpretation of readings.
Topics: Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Forced Expiratory Volume; Humans; Methacholine Chloride; Methacholine Compounds | 1986 |
Flow-volume response to inhaled methacholine in asthmatics; comparison of area under the curve (AFV) with conventional parameters.
Topics: Adolescent; Adult; Aerosols; Aged; Asthma; Bronchial Provocation Tests; Female; Humans; Lung Volume Measurements; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Pulmonary Ventilation; Respiratory Function Tests | 1986 |
Do physicians need objective measurements to diagnose asthma?
Topics: Adult; Asthma; Bronchial Provocation Tests; Diagnosis, Differential; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Research Design; Spirometry | 1986 |
Maximal airway narrowing in humans in vivo. Histamine compared with methacholine.
Topics: Adolescent; Adult; Asthma; Bronchi; Bronchial Provocation Tests; Diagnosis, Differential; Dose-Response Relationship, Drug; Female; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Spirometry | 1986 |
Increase in bronchial responsiveness to methacholine and late asthmatic response after the inhalation of ultrasonically nebulized distilled water.
Topics: Aerosols; Asthma; Bronchi; Bronchial Provocation Tests; Forced Expiratory Volume; Humans; Methacholine Chloride; Methacholine Compounds; Time Factors; Water | 1986 |
Evaluation of non-specific bronchial hyperreactivity in different respiratory diseases.
Topics: Adolescent; Adult; Asthma; Child; Child, Preschool; Cystic Fibrosis; Forced Expiratory Volume; Humans; Kartagener Syndrome; Methacholine Chloride; Methacholine Compounds; Middle Aged; Nebulizers and Vaporizers; Respiratory Hypersensitivity; Respiratory Tract Diseases | 1986 |
Increase in gastroesophageal reflux during methacholine-induced bronchospasm.
Topics: Adult; Asthma; Bronchial Spasm; Esophagus; Female; Gastroesophageal Reflux; Humans; Male; Methacholine Chloride; Methacholine Compounds; Pressure | 1986 |
Methacholine inhalation challenge studies in a selected pediatric population.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Child; Child, Preschool; Humans; Methacholine Chloride; Methacholine Compounds; Statistics as Topic | 1986 |
Associations between asthma history, atopy, and non-specific bronchial responsiveness in young adults.
Topics: Adolescent; Adult; Asthma; Bronchi; Female; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride; Methacholine Compounds; Skin Tests | 1986 |
Comparison of bronchial responses to ultrasonically nebulized distilled water, exercise, and methacholine in asthma.
Topics: Adolescent; Asthma; Bronchi; Child; Constriction, Pathologic; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Nebulizers and Vaporizers; Physical Exertion; Statistics as Topic; Water | 1986 |
Airway effects of purine nucleosides and nucleotides and release with bronchial provocation in asthma.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Asthma; Bronchi; Bronchial Provocation Tests; Forced Expiratory Volume; Histamine; Humans; Inosine; Kinetics; Methacholine Chloride; Methacholine Compounds | 1986 |
Predictive accuracy of late asthmatic reaction to Dermatophagoides pteronyssinus.
Topics: Adolescent; Adult; Airway Resistance; Animals; Asthma; Bronchi; Bronchial Provocation Tests; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Methacholine Compounds; Mites; Time Factors | 1986 |
Late bronchial response and increase in methacholine hyperresponsiveness after exercise and distilled water challenge in atopic subjects with asthma with dual asthmatic response to allergen inhalation.
Topics: Administration, Inhalation; Adolescent; Adult; Allergens; Asthma; Asthma, Exercise-Induced; Bronchi; Bronchial Provocation Tests; Child; Female; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride; Methacholine Compounds; Nebulizers and Vaporizers; Time Factors; Water | 1986 |
Airway response to methacholine during exercise induced refractoriness in asthma.
Topics: Adolescent; Adult; Airway Resistance; Asthma; Asthma, Exercise-Induced; Exercise Test; Female; Humans; Lung; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1986 |
Prevalence of bronchial reactivity to inhaled methacholine in New Zealand children.
Topics: Airway Resistance; Asthma; Child; Humans; Methacholine Chloride; Methacholine Compounds | 1986 |
Hyperventilation syndrome and asthma.
Topics: Adult; Aged; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; Bronchospirometry; Female; Humans; Hyperventilation; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Patient Education as Topic; Retrospective Studies | 1986 |
The relationship between airway obstruction and bronchial hyperreactivity in childhood asthma.
Topics: Adolescent; Airway Obstruction; Asthma; Bronchi; Bronchial Provocation Tests; Child; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Predictive Value of Tests | 1987 |
Bradykinin-induced bronchoconstriction in humans. Mode of action.
Topics: Administration, Inhalation; Aged; Asthma; Bradykinin; Bronchi; Bronchial Provocation Tests; Capsaicin; Constriction; Histamine; Humans; In Vitro Techniques; Methacholine Chloride; Methacholine Compounds; Middle Aged; Muscle, Smooth | 1987 |
Total lung capacity does not change during methacholine-stimulated airway narrowing.
Topics: Adult; Asthma; Female; Forced Expiratory Volume; Humans; Lung; Lung Volume Measurements; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Reference Values | 1986 |
Methacholine responsiveness increases after ultrasonically nebulized water but not after ultrasonically nebulized hypertonic saline in patients with asthma.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Child; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Nebulizers and Vaporizers; Saline Solution, Hypertonic; Sodium Chloride; Ultrasonics; Water | 1987 |
Refractory period to ultrasonic mist of distilled water: relationship to methacholine responsiveness, atopic status, and clinical characteristics.
Topics: Adult; Aerosols; Asthma; Bronchi; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Male; Methacholine Chloride; Methacholine Compounds; Refractory Period, Electrophysiological | 1987 |
Symptoms, atopy, and bronchial response to methacholine in parents with asthma and their children.
Topics: Asthma; Bronchi; Bronchial Provocation Tests; Child; Child, Preschool; Forced Expiratory Volume; Humans; Methacholine Chloride; Methacholine Compounds | 1987 |
[Studies on a comparison between continuous changes in respiratory impedance and in regional ventilatory distribution, and on the sites of airway obstruction induced by the methacholine provocation test].
Topics: Adolescent; Adult; Aged; Asthma; Bronchi; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1986 |
Bronchoprovocation test in the normal and in asthmatics.
Topics: Adult; Asthma; Bronchial Provocation Tests; Female; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1986 |
Methacholine inhalational challenge in the evaluation of chronic cough in children.
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Child; Chronic Disease; Cough; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds | 1986 |
The role of the methacholine challenge in children with chronic cough.
Topics: Adolescent; Adult; Asthma; Child; Chronic Disease; Cough; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Spirometry | 1987 |
Distribution of methacholine inhalation challenge responses in a selected adult population.
Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Asthma; Bronchi; Humans; Methacholine Chloride; Methacholine Compounds; Middle Aged; Respiratory Function Tests | 1987 |
Bronchoalveolar lavage does not alter airway responsiveness in asthmatic subjects.
Topics: Albuterol; Asthma; Bronchi; Bronchial Provocation Tests; Humans; Methacholine Chloride; Methacholine Compounds; Pulmonary Alveoli; Respiratory System; Therapeutic Irrigation | 1987 |
Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with methacholine bronchial hyperresponsiveness.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Forced Expiratory Volume; Histamine; Humans; Hypersensitivity; Methacholine Chloride; Methacholine Compounds; Middle Aged; Pulmonary Alveoli; Rhinitis; Therapeutic Irrigation | 1987 |
Airway responsiveness to histamine or methacholine: advances in measurement and interpretation.
Topics: Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Histamine; Humans; Lung Diseases, Obstructive; Methacholine Chloride; Methacholine Compounds; Respiratory System | 1986 |
Nifedipine decreases sensitivity and reactivity to methacholine in mild asthmatics.
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Nifedipine | 1987 |
Prediction of airway reactivity from responses to a standardized respiratory symptom questionnaire.
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Humans; Lung Diseases, Obstructive; Male; Mass Screening; Methacholine Chloride; Methacholine Compounds; Middle Aged; Respiratory Sounds; Risk; Surveys and Questionnaires | 1987 |
The role of titratable acidity in acid aerosol-induced bronchoconstriction.
Topics: Adult; Aerosols; Air Pollutants; Asthma; Bronchial Provocation Tests; Buffers; Female; Humans; Hydrochloric Acid; Hydrogen-Ion Concentration; Male; Methacholine Chloride; Methacholine Compounds; Sulfuric Acids | 1987 |
Airway hyperresponsiveness in allergic rhinitis. A risk factor for asthma.
Topics: Adolescent; Adult; Asthma; Bronchi; Bronchial Provocation Tests; Child; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Prospective Studies; Rhinitis, Allergic, Seasonal; Risk; Vital Capacity | 1987 |
Airway responsiveness to methacholine during the natural menstrual cycle and the effect of oral contraceptives.
Topics: Adult; Asthma; Bronchial Provocation Tests; Contraceptives, Oral, Hormonal; Female; Forced Expiratory Volume; Humans; Menstrual Cycle; Methacholine Chloride; Methacholine Compounds; Progesterone | 1987 |
Advances in the use of inhalation provocation tests in clinical evaluation.
Topics: Airway Obstruction; Asthma; Bronchial Provocation Tests; Forced Expiratory Volume; Histamine; Humans; Methacholine Chloride; Methacholine Compounds; Occupational Diseases | 1985 |
The effect of methacholine inhalation challenge on regional residual volume in patients with subclinical asthma.
Topics: Adult; Asthma; Female; Forced Expiratory Volume; Humans; Lung Volume Measurements; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Respiratory Therapy | 1985 |
Bronchial hyperresponsiveness to methacholine after exercise in asthmatics.
Topics: Adult; Asthma; Asthma, Exercise-Induced; Exercise Test; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Respiratory Function Tests | 1985 |
Acute and long-term airway hyperreactivity in aluminium-salt exposed workers with nocturnal asthma.
Topics: Adult; Alum Compounds; Aluminum; Aluminum Compounds; Asthma; Bronchial Provocation Tests; Fluorides; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Occupational Diseases; Respiratory Sounds; Smoking; Sulfates; Time Factors; Vital Capacity | 1985 |
The effect of inhaled leukotriene D4 in humans.
Topics: Adult; Aerosols; Asthma; Bronchi; Bronchial Provocation Tests; Constriction, Pathologic; Humans; Lung; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Pulmonary Ventilation; Rhinitis, Allergic, Perennial; SRS-A | 1985 |
Predictors of bronchial hyperexcitability in grainhandlers.
Topics: Adult; Age Factors; Asthma; Bronchial Diseases; Bronchial Provocation Tests; Dust; Edible Grain; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Occupational Diseases; Respiratory Hypersensitivity; Skin Tests; Smoking; Vital Capacity | 1985 |
Asthma and rhinitis due to ethylcyanoacrylate instant glue.
Topics: Adhesives; Adult; Asthma; Bronchial Provocation Tests; Cyanoacrylates; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Radioallergosorbent Test; Rhinitis | 1985 |
Hyperresponsiveness of cough receptors in patients with bronchial asthma.
Topics: Acetates; Acetic Acid; Adolescent; Adult; Asthma; Bronchial Provocation Tests; Child; Child, Preschool; Cough; Differential Threshold; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds | 1985 |
Airway reactivity and lung function in triiodothyronine-induced thyrotoxicosis.
Topics: Adult; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Hyperthyroidism; Lung; Male; Methacholine Chloride; Methacholine Compounds; Triiodothyronine | 1985 |
Effect of corticosteroids on bronchial responsiveness to methacholine in asthmatic children.
Topics: Adolescent; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Child; Female; Forced Expiratory Volume; Humans; Male; Maximal Midexpiratory Flow Rate; Methacholine Chloride; Methacholine Compounds; Prednisone | 1985 |
Antigen-induced enhancement of bronchial reactivity.
Topics: Adult; Antigens; Asthma; Bronchial Diseases; Bronchial Provocation Tests; Humans; Male; Methacholine Chloride; Methacholine Compounds; Respiratory Hypersensitivity | 1985 |
Mediators, airway responsiveness, and asthma.
Topics: Airway Resistance; Asthma; Bronchial Provocation Tests; Dinoprost; Histamine; Humans; Inflammation; Lung; Methacholine Chloride; Methacholine Compounds; Prostaglandins; Prostaglandins F; SRS-A | 1985 |
Differences in responsiveness to hyperventilation and methacholine in asthma and chronic bronchitis.
Topics: Adolescent; Adult; Aged; Asthma; Bronchi; Bronchitis; Cold Temperature; Female; Forced Expiratory Volume; Humans; Hyperventilation; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Pulmonary Ventilation; Vital Capacity | 1985 |
Increased responsiveness to methacholine and histamine after challenge with ultrasonically nebulised water in asthmatic subjects.
Topics: Adult; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Histamine; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Ultrasonics; Water | 1985 |
Effect of circadian rhythm on bronchomotor tone after deep inspiration in normal and in asthmatic subjects.
Topics: Adult; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Catecholamines; Circadian Rhythm; Female; Heart Rate; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Respiration | 1985 |
Airway responsiveness to inhaled antigen, histamine, and methacholine in inbred, ragweed-sensitized dogs.
Topics: Animals; Asthma; Bronchial Provocation Tests; Disease Models, Animal; Dogs; Female; Histamine; Immunization; Immunoglobulin E; Male; Methacholine Chloride; Methacholine Compounds; Pollen; Radioallergosorbent Test; Skin Tests | 1985 |
Upper airway response during bronchoprovocation and asthma attack.
Topics: Adult; Aged; Airway Resistance; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Forced Expiratory Volume; Histamine; Humans; Larynx; Lung Volume Measurements; Methacholine Chloride; Methacholine Compounds; Middle Aged; Pressure; Respiratory Sounds; Trachea; Vital Capacity | 1985 |
[Measurement of bronchial reactivity in asthmatics. I. Use of indices of PC20, TC and R for measuring bronchial reactivity].
Topics: Adolescent; Adult; Asthma; Bronchial Provocation Tests; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1985 |
[Measurement of bronchial reactivity in asthmatics. II. Effects of atropine and metaproterenol on bronchial reactivity in asthmatics].
Topics: Adult; Airway Resistance; Asthma; Atropine; Bronchial Provocation Tests; Female; Humans; Male; Metaproterenol; Methacholine Chloride; Methacholine Compounds; Middle Aged | 1985 |
Comparison of cold air, ultrasonic mist, and methacholine inhalations as tests of bronchial reactivity in normal and asthmatic children.
Topics: Adolescent; Air; Asthma; Bronchial Provocation Tests; Child; Cold Temperature; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Respiratory Function Tests; Ultrasonics | 1985 |
Recurrent acute bronchitis: the association with undiagnosed bronchial asthma.
Topics: Acute Disease; Adult; Asthma; Bronchial Provocation Tests; Bronchitis; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Prospective Studies; Recurrence; Respiratory Function Tests; Smoking | 1985 |
Quantitative assays of pharmacologic aerosols used in studying asthma.
Topics: Aerosols; Animals; Asthma; Biological Assay; Bronchial Provocation Tests; Chromatography, Ion Exchange; Drug Contamination; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Methacholine Chloride; Methacholine Compounds; Muscle, Smooth; Particle Size; Spectrophotometry | 1985 |
The effect of age on methacholine response.
Topics: Adolescent; Adult; Aged; Aging; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Retrospective Studies | 1985 |
The effect of inspiratory flow rate regulation on nebulizer output and on human airway response to methacholine aerosol.
Topics: Aerosols; Asthma; Dose-Response Relationship, Drug; Humans; Inspiratory Capacity; Methacholine Chloride; Methacholine Compounds; Pulmonary Ventilation | 1985 |
Parasympathetic activity assessed by diving reflex and by airway response to methacholine in bronchial asthma and rhinitis.
Topics: Adult; Airway Resistance; Asthma; Diving; Dose-Response Relationship, Drug; Female; Heart Rate; Humans; Male; Methacholine Chloride; Methacholine Compounds; Parasympathetic Nervous System; Reflex; Rhinitis | 1985 |
[Evaluation of bronchial hyperresponsiveness in asthmatic children measuring by methacholine inhalation challenge].
Topics: Adolescent; Adult; Age Factors; Asthma; Bronchi; Bronchial Provocation Tests; Child; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds | 1985 |
Increased bronchial hypersensitivity after early and late bronchial reactions provoked by allergen inhalation.
Topics: Adolescent; Adult; Allergens; Asthma; Bronchi; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Peak Expiratory Flow Rate; Physical Exertion; Time Factors | 1985 |