Page last updated: 2024-08-17

methacholine chloride and Aging

methacholine chloride has been researched along with Aging in 66 studies

Research

Studies (66)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (15.15)	18.7374
1990's	30 (45.45)	18.2507
2000's	19 (28.79)	29.6817
2010's	7 (10.61)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Boulay, P; Fujii, N; Kenny, GP; McGarr, GW; Nishiyasu, T; Sigal, RJ	2
Bourque, SL; Davidge, ST; Gragasin, FS	1
Asai, K; Hirata, K; Kanazawa, H; Kyoh, S; Tochino, Y	1
Basu, S; Detillieux, K; Halayko, AJ; Jha, A; Klonisch, T; Sharma, P; Stelmack, GL; Unruh, H	1
Milanese, M; Perrella, A; Scala, R; Scalese, M; Scichilone, N; Sposato, B	1
Fujimoto, K; Hanaoka, M; Koizumi, T; Komatsu, Y; Kubo, K; Urushihata, K; Yasuo, M	1
Bennett, BA; Mitzner, W; Tankersley, CG	1
Armstrong, SJ; Davidge, ST; Stewart, KG; Zhang, Y	1
Clem, C; Kisling, J; Tepper, RS; Weist, A; Williams, T	1
Guevarra, L; Litonjua, AA; O'Connor, GT; Sparrow, D; Tollerud, DJ; Weiss, ST	1
Parker, AL	1
Bellia, V; Catalano, F; Marchese, R; Scichilone, N; Togias, A; Vignola, AM	2
Colasurdo, GN; Dakhama, A; Fratelli, C; Larsen, GL; Loader, J; Nguyen, DD	1
Chiappetta, CL; Colasurdo, GN; Collins, RA; Gualano, RC; Hantos, Z; Sly, PD; Turner, DJ; Zosky, GR	1
Jurkiewicz, A; Jurkiewicz, NH; Lopes, GS; Neto, AC; Smaili, SS; Vladimirova, I	1
Bozanich, EM; Collins, RA; Hantos, Z; Jánosi, TZ; Sly, PD; Thamrin, C; Turner, DJ	1
Alexeeff, SE; Litonjua, AA; Schwartz, J; Sparrow, D; Suh, H; Vokonas, PS	1
Brown, M; Camoretti-Mercado, B; Chen, B; Dowell, ML; Eaton, E; Fleisher, J; Husain, A; Kedainis, D; Lakser, OJ; Levin, SI; McCauley, J; Mitchell, RW; Naclerio, R; Pinto, LH; Shimomura, K; Shuster, D; Siepka, SM; Solway, J; Song, EJ; Sperling, AI; Turek, FW	1
Sato, K	1
Burrows, B; Flannery, EM; Herbison, GP; Holdaway, MD; Sears, MR; Silva, PA	1
O'Connor, GT; Sparrow, D; Weiss, ST	2
Le Souëf, PN; Sears, MR; Sherrill, D	1
Charan, NB; Connolly, MJ; Crowley, JJ; Nielson, CP; Vestal, RE	2
Kato, M; Maeda, S; Mirokawa, A; Mochizuki, H; Shigeta, M; Shimizu, T	1
Annema, JT; Koëter, GH; O'Connor, GT; Postma, DS; Rijcken, B; Sparrow, D; Weiss, ST	1
Fukuchi, Y; Matsuse, T; Nagase, T; Orimo, H; Teramoto, S	1
Du, T; Ludwig, M; Martin, JG; Styhler, A; Tepper, RS	1
Kuroume, T; Mochizuki, H; Morikawa, A; Shigeta, M; Tokuyama, K	1
Cavallin, S; Sato, F; Sato, K; Sato, KT	1
Bric, JM; Joad, JP; Pinkerton, KE	1
O'Connor, GT; Rosner, B; Sparrow, D; Weiss, ST	1
Tepper, RS	1
Basner, RC; O'Connor, GT; Rosner, B; Sparrow, D; Weiss, ST	1
Gottlieb, DJ; O'Connor, GT; Sparrow, D; Weiss, ST	1
Bakan, E; Gunst, SJ; Shen, X; Tepper, RS	1
Omlor, GJ; Quinn, LM; Schramm, CM	1
Chuang, CC; Lee, HL; Wang, SR	1
Davidge, ST; Hubel, CA; McLaughlin, MK	1
DeMolles, D; Ingram, RH; O'Connor, GT; Sparrow, D; Weiss, ST	1
Itoh, T; Mitsuma, T; Miyakawa, A; Nagamatsu, M; Niwa, H; Pleasure, D; Sobue, G	1
Litonjua, AA; Sparrow, D; Weiss, ST	1
Lind, L; Millgård, J; Sarabi, M	1
Davidge, ST; Stewart, KG; Zhang, Y	1
Bellia, V; Bonsignore, G; Bucchieri, S; Cibella, F; Cossi, S; Cuttitta, G; Grassi, V	1
Gunst, SJ; Ramchandani, R; Shen, X; Tepper, RS	1
Avadhanam, KP; Bric, JM; Joad, JP; Kott, KS; Pinkerton, KE; Plopper, CG	1
Chism, D; Johnston, RA; Krishna Murthy, GG; Schwartzman, IN; Shore, SA	1
Celedon, JC; DeMolles, D; Litonjua, AA; Sparrow, D; Weiss, ST	1
Le Souëf, PN	1
O'Connor, GT; Rosner, B; Segal, MR; Sparrow, D; Weiss, ST	1
Halayko, A; Kelly, EA; Leff, AR; Mitchell, RW; Munoz, NM; Murphy, TM; Roach, J; Roy, L; Stephens, NL	1
O'Connor, GT; Parker, DR; Segal, MR; Sparrow, D; Weiss, ST	1
Montgomery, GL; Tepper, RS	1
O'Connor, GT; Segal, MR; Sparrow, D; Weiss, ST	1
Byard, PJ; Davis, PB	1
Hudson, I; Kelly, WJ; Olinsky, A; Pain, MC; Phelan, PD; Raven, J	1
Fan, ZS; Jin, GQ; Liu, YN; Piao, ZL; Zhang, Y	1
Duckles, SP; Hynes, MR	1
Barry, CL; Colton, T; O'Connor, G; Sparrow, D; Weiss, ST	1
O'Connor, G; Segal, M; Sparrow, D; Taylor, D; Weiss, S	1
Bewtra, A; Hopp, RJ; Nair, NM; Townley, RG	1
Breuing, EP; Kobashi, YL; Markus, RP	1

Reviews

1 review(s) available for methacholine chloride and Aging

Article	Year
Age-related changes in the effects of drugs on the sweat glands. Pharmacology & therapeutics, 1984, Volume: 24, Issue:3 Topics: Adult; Aging; Animals; Eccrine Glands; Haplorhini; Humans; Methacholine Chloride; Methacholine Compounds; Middle Aged; Sweat; Sweat Glands	1984

Trials

1 trial(s) available for methacholine chloride and Aging

Article	Year
Age-related changes in bronchial hyperreactivity during the adolescent period. The Journal of asthma : official journal of the Association for the Care of Asthma, 1994, Volume: 31, Issue:6 Topics: Adolescent; Adult; Aging; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Female; Humans; Male; Methacholine Chloride; Prognosis; Severity of Illness Index	1994

Other Studies

64 other study(ies) available for methacholine chloride and Aging

Article	Year
Ageing augments nicotinic and adenosine triphosphate-induced, but not muscarinic, cutaneous vasodilatation in women. Experimental physiology, 2019, Volume: 104, Issue:12 Topics: Adenosine Triphosphate; Adolescent; Adult; Aged; Aging; Dose-Response Relationship, Drug; Female; Forearm; Humans; Laser-Doppler Flowmetry; Methacholine Chloride; Microcirculation; Middle Aged; Muscarinic Agonists; Nicotine; Skin; Vasodilation; Young Adult	2019
Ageing attenuates muscarinic-mediated sweating differently in men and women with no effect on nicotinic-mediated sweating. Experimental dermatology, 2019, Volume: 28, Issue:8 Topics: Adult; Aged; Aging; Female; Healthy Volunteers; Humans; Male; Methacholine Chloride; Middle Aged; Nicotine; Receptors, Muscarinic; Receptors, Nicotinic; Sweating; Young Adult	2019
Propofol increases vascular relaxation in aging rats chronically treated with the angiotensin-converting enzyme inhibitor captopril. Anesthesia and analgesia, 2013, Volume: 116, Issue:4 Topics: Aging; Anesthetics, Intravenous; Angiotensin-Converting Enzyme Inhibitors; Animals; Area Under Curve; Blood Pressure; Captopril; Endothelium, Vascular; Enzyme Inhibitors; Methacholine Chloride; Muscarinic Agonists; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Phenylephrine; Propofol; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents	2013
Potential role of pentosidine on susceptibility to small airway closure in elderly and smoking asthma. Respiratory medicine, 2014, Volume: 108, Issue:5 Topics: Adult; Aged; Aging; Arginine; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Case-Control Studies; Female; Forced Expiratory Volume; Humans; Lysine; Male; Methacholine Chloride; Middle Aged; Respiratory Function Tests; Smoking; Sputum; Vital Capacity; Young Adult	2014
Characterization of the dystrophin-glycoprotein complex in airway smooth muscle: role of δ-sarcoglycan in airway responsiveness. Canadian journal of physiology and pharmacology, 2015, Volume: 93, Issue:3 Topics: Aging; Animals; Bronchoconstrictor Agents; Caveolin 1; Dogs; Dystroglycans; Dystrophin; Glycoproteins; Lung; Methacholine Chloride; Mice; Mice, Transgenic; Muscle, Smooth; Sarcoglycans; Trachea	2015
Smoking and Obesity Increase Airway Hyperesponsiveness Risk in the Elderly. Current aging science, 2016, Volume: 9, Issue:4 Topics: Adolescent; Adult; Aged; Aging; Bronchial Provocation Tests; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Obesity; Respiratory Hypersensitivity; Retrospective Studies; Risk Factors; Smoking; Vital Capacity; Young Adult	2016
Airway hyper-responsiveness in young adults with asthma that remitted either during or before adolescence. Respirology (Carlton, Vic.), 2009, Volume: 14, Issue:2 Topics: Adolescent; Adult; Aging; Asthma; Bronchial Provocation Tests; Case-Control Studies; Female; Humans; Immunoglobulin E; Male; Methacholine Chloride; Nitric Oxide; Recurrence; Remission, Spontaneous; Respiratory Function Tests; Respiratory Hypersensitivity; Risk Factors	2009
The effects of age and carbon black on airway resistance in mice. Inhalation toxicology, 2012, Volume: 24, Issue:14 Topics: Age Factors; Aging; Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Inhalation Exposure; Lung; Male; Methacholine Chloride; Mice; Mice, Inbred C57BL; Muscle, Smooth; Particulate Matter; Risk Factors; Soot	2012
Estrogen replacement reduces PGHS-2-dependent vasoconstriction in the aged rat. American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:3 Topics: Aging; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Estradiol; Female; Isoenzymes; Mesenteric Arteries; Methacholine Chloride; Nitric Oxide; Nitrobenzenes; Ovariectomy; Parasympathomimetics; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; Sulfonamides; Vasoconstriction; Vasodilation	2002
Volume history and effect on airway reactivity in infants and adults. Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 93, Issue:3 Topics: Adult; Aging; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child, Preschool; Female; Forced Expiratory Flow Rates; Humans; Infant; Lung; Lung Volume Measurements; Male; Medical Records; Methacholine Chloride; Middle Aged; Reference Values; Respiratory Mechanics	2002
Serum interferon-gamma is associated with longitudinal decline in lung function among asthmatic patients: the Normative Aging Study. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2003, Volume: 90, Issue:4 Topics: Aged; Aged, 80 and over; Aging; Asthma; Boston; Bronchial Provocation Tests; Cohort Studies; Female; Forced Expiratory Volume; Humans; Interferon-gamma; Interleukin-5; Interleukins; Longitudinal Studies; Lung; Male; Methacholine Chloride; Middle Aged; Prospective Studies; Skin Tests; Smoking; Spirometry; Surveys and Questionnaires; Vital Capacity	2003
Aging does not affect beta-agonist responsiveness after methacholine-induced bronchoconstriction. Journal of the American Geriatrics Society, 2004, Volume: 52, Issue:3 Topics: Administration, Inhalation; Adolescent; Adrenergic beta-Agonists; Adult; Aged; Aged, 80 and over; Aging; Albuterol; Anti-Bacterial Agents; Bronchoconstriction; Bronchodilator Agents; Child; Child, Preschool; Female; Forced Expiratory Volume; Humans; Ipratropium; Male; Metaproterenol; Methacholine Chloride; Middle Aged; Retrospective Studies; Total Lung Capacity	2004
Bronchodilatory effect of deep inspiration is absent in subjects with mild COPD. Chest, 2004, Volume: 125, Issue:6 Topics: Aged; Aged, 80 and over; Aging; Bronchial Provocation Tests; Case-Control Studies; Female; Forced Expiratory Volume; Humans; Inhalation; Lung Volume Measurements; Male; Methacholine Chloride; Middle Aged; Probability; Prognosis; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Reference Values; Respiratory Mechanics; Sensitivity and Specificity; Spirometry; Statistics, Nonparametric; Vital Capacity	2004
Mechanisms determining cholinergic neural responses in airways of young and mature rabbits. Pediatric pulmonology, 2004, Volume: 38, Issue:2 Topics: Acetylcholine; Acetylcholinesterase; Aging; Animals; Autonomic Nervous System; Bronchoconstrictor Agents; Choline O-Acetyltransferase; Electric Stimulation; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Nerve Growth Factors; Rabbits; Receptor, Muscarinic M2; Receptors, Cholinergic; Respiratory Mechanics; Substance P; Trachea	2004
The bronchodilatory effect of deep inspiration diminishes with aging. Respiratory medicine, 2004, Volume: 98, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Aging; Bronchi; Bronchoconstrictor Agents; Female; Humans; Inhalation; Male; Methacholine Chloride; Middle Aged; Vital Capacity	2004
Lack of long-term effects of respiratory syncytial virus infection on airway function in mice. Respiratory physiology & neurobiology, 2007, Jun-15, Volume: 156, Issue:3 Topics: Aging; Anesthesia; Animals; Body Weight; Bronchoconstriction; Electric Stimulation; In Vitro Techniques; Lung; Membrane Potentials; Methacholine Chloride; Mice; Mice, Inbred BALB C; Muscarinic Agonists; Muscle Contraction; Respiratory Function Tests; Respiratory Mechanics; Respiratory Syncytial Virus Infections; Trachea	2007
Aging-induced decrease of cholinergic response and calcium sensitivity on rat jejunum contractions. The journals of gerontology. Series A, Biological sciences and medical sciences, 2007, Volume: 62, Issue:3 Topics: Adrenergic Agonists; Aging; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Diamines; Isradipine; Jejunum; Male; Methacholine Chloride; Muscarinic Agonists; Muscarinic Antagonists; Peristalsis; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Adrenergic, alpha; Receptors, Muscarinic	2007
Methacholine responsiveness in mice from 2 to 8 wk of age. Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 103, Issue:2 Topics: Aging; Animals; Asthma; Bronchial Provocation Tests; Bronchoconstrictor Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Infusions, Intravenous; Lung; Lung Volume Measurements; Methacholine Chloride; Mice; Mice, Inbred BALB C; Pregnancy; Respiratory Mechanics	2007
Ozone exposure and lung function: effect modified by obesity and airways hyperresponsiveness in the VA normative aging study. Chest, 2007, Volume: 132, Issue:6 Topics: Aged; Aging; Bronchial Hyperreactivity; Bronchial Provocation Tests; Environmental Exposure; Forced Expiratory Volume; Humans; Likelihood Functions; Male; Methacholine Chloride; Obesity; Ozone; Regression Analysis; Spirometry; United States; Veterans; Vital Capacity	2007
Gene-environment interactions in a mutant mouse kindred with native airway constrictor hyperresponsiveness. Mammalian genome : official journal of the International Mammalian Genome Society, 2008, Volume: 19, Issue:1 Topics: Aerosols; Aging; Airway Obstruction; Animals; Blood Cell Count; Bronchial Hyperreactivity; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Environment; Female; Gene Regulatory Networks; Lung; Male; Methacholine Chloride; Mice; Mice, Mutant Strains; Mutagenesis; Pedigree; Phenotype; Plethysmography	2008
Relation of the course of bronchial responsiveness from age 9 to age 15 to allergy. American journal of respiratory and critical care medicine, 1995, Volume: 152, Issue:4 Pt 1 Topics: Adolescent; Aging; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Child; Cohort Studies; Cross-Sectional Studies; Female; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Male; Methacholine Chloride; Sex Factors; Skin Tests; Spirometry	1995
A prospective longitudinal study of methacholine airway responsiveness as a predictor of pulmonary-function decline: the Normative Aging Study. American journal of respiratory and critical care medicine, 1995, Volume: 152, Issue:1 Topics: Aging; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cohort Studies; Humans; Linear Models; Longitudinal Studies; Lung; Lung Diseases, Obstructive; Male; Methacholine Chloride; Middle Aged; Predictive Value of Tests; Prospective Studies; Risk Factors; Spirometry; Time Factors	1995
The effect of size and age of subject on airway responsiveness in children. American journal of respiratory and critical care medicine, 1995, Volume: 152, Issue:2 Topics: Adolescent; Aging; Asthma; Body Constitution; Body Height; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstriction; Child; Child, Preschool; Cohort Studies; Female; Forced Expiratory Volume; Functional Residual Capacity; Humans; Longitudinal Studies; Male; Methacholine Chloride; Respiratory Sounds; Sex Factors; Spirometry; Total Lung Capacity	1995
Impaired bronchodilator response to albuterol in healthy elderly men and women. Chest, 1995, Volume: 108, Issue:2 Topics: Adult; Aged; Aging; Albuterol; Analysis of Variance; Bronchi; Bronchial Provocation Tests; Bronchoconstriction; Female; Forced Expiratory Flow Rates; Humans; Male; Methacholine Chloride; Middle Aged; Reference Values; Regression Analysis; Time Factors	1995
Age-related changes in bronchial hyperreactivity to methacholine in asthmatic children. American journal of respiratory and critical care medicine, 1995, Volume: 152, Issue:3 Topics: Adolescent; Age Factors; Aging; Asthma; Blood Gas Monitoring, Transcutaneous; Bronchial Hyperreactivity; Bronchial Provocation Tests; Child; Child, Preschool; Female; Humans; Male; Matched-Pair Analysis; Methacholine Chloride	1995
Chronic respiratory symptoms and airway responsiveness to methacholine are associated with eosinophilia in older men: the Normative Aging Study. The European respiratory journal, 1995, Volume: 8, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Aging; Bronchial Hyperreactivity; Bronchial Provocation Tests; Eosinophilia; Humans; Hypersensitivity; Longitudinal Studies; Lung Diseases, Obstructive; Male; Methacholine Chloride; Middle Aged; Skin Tests	1995
Mechanical interdependence in relation to age: effects of lung volume on airway resistance in rats. Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 77, Issue:3 Topics: Aging; Airway Resistance; Animals; Elasticity; Lung; Lung Volume Measurements; Male; Methacholine Chloride; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Respiratory Mechanics; Total Lung Capacity	1994
Increased maximal pulmonary response to methacholine and airway smooth muscle in immature compared with mature rabbits. American journal of respiratory and critical care medicine, 1995, Volume: 151, Issue:3 Pt 1 Topics: Aging; Airway Resistance; Animals; Animals, Newborn; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Lung; Methacholine Chloride; Muscle, Smooth; Rabbits; Respiration, Artificial	1995
Normal range of methacholine responsiveness in relation to prechallenge pulmonary function. The Normative Aging Study. Chest, 1994, Volume: 105, Issue:3 Topics: Adult; Aged; Aging; Asthma; Bronchial Provocation Tests; Cohort Studies; Forced Expiratory Volume; Humans; Linear Models; Longitudinal Studies; Male; Methacholine Chloride; Middle Aged; Reference Values; Sensitivity and Specificity; Vital Capacity	1994
Secretion of ions and pharmacological responsiveness in the mouse paw sweat gland. Clinical science (London, England : 1979), 1994, Volume: 86, Issue:2 Topics: Aging; Animals; Colforsin; Culture Techniques; Cyclic AMP; Eccrine Glands; Forelimb; Isoproterenol; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Potassium; Sodium	1994
Peripheral mononuclear leucocyte beta adrenoceptors and non-specific bronchial responsiveness to methacholine in young and elderly normal subjects and asthmatic patients. Thorax, 1994, Volume: 49, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Asthma; Bronchi; Bronchial Provocation Tests; Epinephrine; Female; Forced Expiratory Flow Rates; Humans; Immunoglobulin E; Leukocytes, Mononuclear; Male; Methacholine Chloride; Middle Aged; Norepinephrine; Receptors, Adrenergic, beta	1994
Effects of sidestream smoke exposure and age on pulmonary function and airway reactivity in developing rats. Pediatric pulmonology, 1993, Volume: 16, Issue:5 Topics: Aging; Airway Resistance; Animals; Animals, Newborn; Blood Pressure; Bronchial Provocation Tests; Female; In Vitro Techniques; Lung; Lung Compliance; Methacholine Chloride; Organ Size; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Respiratory Mechanics; Serotonin; Tobacco Smoke Pollution	1993
Predictors of longitudinal change in methacholine airway responsiveness among middle-aged and older men: the Normative Aging Study. American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:2 Pt 1 Topics: Aged; Aging; Asthma; Basophils; Boston; Bronchial Hyperreactivity; Bronchial Provocation Tests; Cohort Studies; Humans; Linear Models; Longitudinal Studies; Male; Methacholine Chloride; Middle Aged; Smoking; Time Factors	1994
Maturation affects the maximal pulmonary response to methacholine in rabbits. Pediatric pulmonology, 1993, Volume: 16, Issue:1 Topics: Aging; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Forced Expiratory Flow Rates; Methacholine Chloride; Rabbits; Respiratory Mechanics; Vital Capacity	1993
Predictors of the new onset of wheezing among middle-aged and older men. The Normative Aging Study. The American review of respiratory disease, 1993, Volume: 147, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Aging; Asthma; Boston; Humans; Immunoglobulin E; Male; Methacholine Chloride; Middle Aged; Prognosis; Prospective Studies; Regression Analysis; Respiratory Sounds; Risk Factors; Skin Tests; Spirometry; Surveys and Questionnaires	1993
Skin test reactivity to common aeroallergens and decline of lung function. The Normative Aging Study. American journal of respiratory and critical care medicine, 1996, Volume: 153, Issue:2 Topics: Aging; Allergens; Bronchial Provocation Tests; Dust; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Longitudinal Studies; Lung; Male; Methacholine Chloride; Middle Aged; Pollen; Reference Values; Skin Tests; Spirometry; Vital Capacity	1996
Maximal airway response in mature and immature rabbits during tidal ventilation. Journal of applied physiology (Bethesda, Md. : 1985), 1995, Volume: 79, Issue:4 Topics: Aging; Air Pressure; Airway Resistance; Animals; Blood Pressure; Bronchoconstrictor Agents; Elasticity; Forced Expiratory Flow Rates; Injections, Intravenous; Methacholine Chloride; Oxygen; Pulmonary Alveoli; Rabbits; Respiration, Artificial; Respiratory Physiological Phenomena; Respiratory System	1995
Ontogeny of beta-adrenergic desensitization in rabbit tracheal smooth muscle. Pediatric pulmonology, 1996, Volume: 22, Issue:4 Topics: Adrenergic beta-Agonists; Aging; Animals; Animals, Newborn; Dinoprostone; Dose-Response Relationship, Drug; Isometric Contraction; Isoproterenol; Methacholine Chloride; Muscle, Smooth; Potassium Chloride; Rabbits; Receptors, Adrenergic, beta; Time Factors; Trachea	1996
Bronchial responsiveness of aged asthmatic patients to bronchodilator and methacholine. Asian Pacific journal of allergy and immunology, 1996, Volume: 14, Issue:1 Topics: Adult; Aging; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchodilator Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Vital Capacity	1996
Impairment of vascular function is associated with an age-related increase of lipid peroxidation in rats. The American journal of physiology, 1996, Volume: 271, Issue:6 Pt 2 Topics: Aging; Animals; Arteries; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; Hydrazines; Lipid Peroxides; Meclofenamic Acid; Methacholine Chloride; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents; Vasodilation	1996
Volume history effects and airway responsiveness in middle-aged and older men. The Normative Aging Study. American journal of respiratory and critical care medicine, 1997, Volume: 155, Issue:3 Topics: Aged; Aging; Bronchi; Bronchial Provocation Tests; Bronchoconstrictor Agents; Bronchodilator Agents; Forced Expiratory Volume; Humans; Isoproterenol; Longitudinal Studies; Lung; Lung Volume Measurements; Male; Methacholine Chloride; Middle Aged; Muscle, Smooth; Reference Values; Spirometry	1997
Nerve growth factor maintains regulation of intracellular calcium in neonatal sympathetic neurons but not in mature or aged neurons. Neuroscience, 1998, Volume: 82, Issue:3 Topics: Aging; Animals; Animals, Newborn; Caffeine; Calcium; Cells, Cultured; Central Nervous System Stimulants; Fluorescent Dyes; Fura-2; Methacholine Chloride; Nerve Growth Factors; Neurons; Parasympathomimetics; Rats; Rats, Sprague-Dawley; Superior Cervical Ganglion; Sympathetic Nervous System	1998
The FEF25-75/FVC ratio is associated with methacholine airway responsiveness. The normative aging study. American journal of respiratory and critical care medicine, 1999, Volume: 159, Issue:5 Pt 1 Topics: Adult; Aged; Aged, 80 and over; Aging; Bronchi; Bronchoconstrictor Agents; Bronchography; Humans; Lung; Male; Maximal Midexpiratory Flow Rate; Methacholine Chloride; Middle Aged; Radiography, Thoracic; Reference Values; Trachea; Vital Capacity	1999
Effects of age, gender and metabolic factors on endothelium-dependent vasodilation: a population-based study. Journal of internal medicine, 1999, Volume: 246, Issue:3 Topics: Adult; Aged; Aging; Analysis of Variance; Blood Flow Velocity; Endothelium, Vascular; Female; Forearm; Humans; Hyperemia; Male; Methacholine Chloride; Middle Aged; Nitroprusside; Parasympathomimetics; Plethysmography; Reference Values; Sex Characteristics; Vasodilation; Vasodilator Agents	1999
Aging increases PGHS-2-dependent vasoconstriction in rat mesenteric arteries. Hypertension (Dallas, Tex. : 1979), 2000, Volume: 35, Issue:6 Topics: Aging; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 2; Enzyme Inhibitors; Fatty Acids, Unsaturated; Female; Hydrazines; In Vitro Techniques; Isoenzymes; Mesenteric Arteries; Methacholine Chloride; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Vasoconstriction; Vasodilation	2000
Changes in FVC during methacholine-induced bronchoconstriction in elderly patients with asthma: bronchial hyperresponsiveness and aging. Chest, 2001, Volume: 119, Issue:6 Topics: Adult; Aged; Aging; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Middle Aged; Vital Capacity	2001
Bronchoprotective and bronchodilatory effects of deep inspiration in rabbits subjected to bronchial challenge. Journal of applied physiology (Bethesda, Md. : 1985), 2001, Volume: 91, Issue:6 Topics: Aging; Airway Resistance; Animals; Bronchi; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Methacholine Chloride; Rabbits; Respiratory Physiological Phenomena; Tidal Volume	2001
Methacholine responsiveness of proximal and distal airways of monkeys and rats using videomicrometry. Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 92, Issue:3 Topics: Aging; Animals; Bronchi; Bronchoconstrictor Agents; Female; In Vitro Techniques; Macaca mulatta; Male; Methacholine Chloride; Microscopy, Video; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley	2002
Ozone-induced airway hyperresponsiveness is reduced in immature mice. Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 92, Issue:3 Topics: Administration, Inhalation; Aging; Animals; Animals, Newborn; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Dose-Response Relationship, Drug; Female; Male; Methacholine Chloride; Mice; Mice, Inbred Strains; Oxidants, Photochemical; Ozone; Respiration	2002
Association of body mass index with the development of methacholine airway hyperresponsiveness in men: the Normative Aging Study. Thorax, 2002, Volume: 57, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Aging; Body Mass Index; Bronchi; Bronchoconstrictor Agents; Cohort Studies; Forced Expiratory Volume; Humans; Logistic Models; Longitudinal Studies; Male; Methacholine Chloride; Middle Aged; Regression Analysis; Vital Capacity	2002
Validity of methods used to test airway responsiveness in children. Lancet (London, England), 1992, May-23, Volume: 339, Issue:8804 Topics: Adolescent; Aerosols; Aging; Asthma; Body Weight; Bronchial Hyperreactivity; Child; Child, Preschool; Humans; Infant; Methacholine Chloride; Respiratory System	1992
The influence of age and level of pulmonary function on nonspecific airway responsiveness. The Normative Aging Study. The American review of respiratory disease, 1991, Volume: 143, Issue:5 Pt 1 Topics: Adult; Aged; Aged, 80 and over; Aging; Bronchial Provocation Tests; Bronchoconstriction; Cohort Studies; Forced Expiratory Volume; Humans; Longitudinal Studies; Male; Methacholine Chloride; Middle Aged; Regression Analysis; Smoking	1991
Effect of maturational changes in myosin content and morphometry on airway smooth muscle contraction. The American journal of physiology, 1991, Volume: 260, Issue:6 Pt 1 Topics: Aging; Animals; Blotting, Western; Bronchi; Dose-Response Relationship, Drug; In Vitro Techniques; Isometric Contraction; Male; Methacholine Chloride; Muscle Development; Muscle, Smooth; Myosins; Peptide Mapping; Potassium Chloride; Swine; Trachea	1991
The relationship of nonspecific airway responsiveness and atopy to the rate of decline of lung function. The Normative Aging Study. The American review of respiratory disease, 1990, Volume: 141, Issue:3 Topics: Adult; Aged; Aging; Bronchial Provocation Tests; Cohort Studies; Eosinophils; Follow-Up Studies; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Leukocyte Count; Lung; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Regression Analysis; Respiratory Hypersensitivity; Skin Tests; Smoking	1990
Changes in airway reactivity with age in normal infants and young children. The American review of respiratory disease, 1990, Volume: 142, Issue:6 Pt 1 Topics: Aging; Bronchial Provocation Tests; Bronchoconstriction; Cross-Sectional Studies; Female; Functional Residual Capacity; Humans; Infant; Longitudinal Studies; Male; Methacholine Chloride	1990
Smoking, atopy, and methacholine airway responsiveness among middle-aged and elderly men. The Normative Aging Study. The American review of respiratory disease, 1989, Volume: 140, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Aging; Bronchi; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Eosinophils; Forced Expiratory Volume; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Leukocyte Count; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Skin Tests; Smoking	1989
Relationships among airway reactivity, pupillary alpha-adrenergic and cholinergic responsiveness, and age. Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 65, Issue:1 Topics: Adolescent; Adult; Aged; Aging; Airway Resistance; Carbachol; Female; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Phenylephrine; Pupil	1988
Childhood asthma and adult lung function. The American review of respiratory disease, 1988, Volume: 138, Issue:1 Topics: Adult; Aging; Asthma; Child; Female; Humans; Longitudinal Studies; Lung; Lung Diseases, Obstructive; Male; Methacholine Chloride; Methacholine Compounds; Prospective Studies; Respiratory Function Tests; Smoking	1988
Effects of aging on airway hyperreactivity in normal persons. Chinese medical journal, 1986, Volume: 99, Issue:12 Topics: Adolescent; Adult; Age Factors; Aged; Aging; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Child; Female; Humans; Lung; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged	1986
Effect of increasing age on the endothelium-mediated relaxation of rat blood vessels in vitro. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2 Topics: Aging; Animals; Calcimycin; Endothelium; In Vitro Techniques; Male; Methacholine Chloride; Methacholine Compounds; Methoxamine; Norepinephrine; Rats; Rats, Inbred F344; Vasodilation	1987
The relationship of nonspecific bronchial responsiveness to the occurrence of respiratory symptoms and decreased levels of pulmonary function. The Normative Aging Study. The American review of respiratory disease, 1987, Volume: 135, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Aging; Bronchi; Bronchial Provocation Tests; Cross-Sectional Studies; Forced Expiratory Volume; Humans; Longitudinal Studies; Lung; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Respiration Disorders; Respiratory Sounds; Smoking; Vital Capacity	1987
Analysis of dose-response curves to methacholine. An approach suitable for population studies. The American review of respiratory disease, 1987, Volume: 136, Issue:6 Topics: Aging; Asthma; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Forced Expiratory Volume; Humans; Longitudinal Studies; Lung; Male; Methacholine Chloride; Methacholine Compounds; Reference Values	1987
The effect of age on methacholine response. The Journal of allergy and clinical immunology, 1985, Volume: 76, Issue:4 Topics: Adolescent; Adult; Aged; Aging; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Retrospective Studies	1985
Age-related changes in the reactivity of the rat jejunum to cholinoceptor agonists. European journal of pharmacology, 1985, Sep-24, Volume: 115, Issue:2-3 Topics: Acetylcholine; Acetylcholinesterase; Aging; Animals; Atropine; Barium; Cholinesterases; In Vitro Techniques; Jejunum; Male; Methacholine Chloride; Methacholine Compounds; Muscle Contraction; Muscle, Smooth; Parasympathomimetics; Potassium Chloride; Rats; Rats, Inbred Strains	1985