methacetin has been researched along with Pregnancy in 5 studies
methacetin: RN given refers to parent cpd
methacetin : A member of the class of acetamides that is paracetamol in which the hydrogen of phenolic hydroxy group has been replaced by a methyl group.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lalazar, G | 1 |
| Adar, T | 1 |
| Ilan, Y | 1 |
| Krumbiegel, P | 4 |
| Stolz, L | 1 |
| Herbarth, O | 1 |
| Braun, W | 1 |
| Boehm, G | 2 |
| Kausch, S | 1 |
| Wirsing, A | 1 |
| Müller, DM | 1 |
| Teichmann, B | 1 |
| Günther, K | 2 |
| Faust, H | 2 |
| Möbius, G | 1 |
| Hirschberg, K | 2 |
| Schneider, G | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| 13C-Methacetin Breath Test for the Prediction of Outcome in in Acute Liver Injury or Acute Liver Failure[NCT02786836] | Phase 2/Phase 3 | 76 participants (Actual) | Interventional | 2016-06-10 | Completed | ||
| Development of a Breath Test for Monitoring Liver Metabolic Function in Patients With Chronic Liver Disease and Cirrhosis[NCT00244569] | Phase 3 | 120 participants (Anticipated) | Interventional | 2005-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The relationship between the cPDR (cumulative PDR of metabolized 13C-Methacetin 20 minutes after ingestion) in single time points of MBT measurements and TFS and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: The first MBT reading either on Day 1 or Day 2 and Day 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Day 1 or 2 MBT/transplant free survival at Day 21 | Day 1 or 2 MBT & Day 21 non-TFS | |
| 13C-Methacetin Breath Test (MBT) | 1.4 | 0.2 |
Peak PDR is the maximal percent dose recovery (PDR) rate which reflects the maximum rate of metabolism of 13C-methacetin measured as the change in 13CO2 / 12CO2 (normal carbon dioxide) ratio after ingestion of 13C-methacetin normalized using the patient's height and weight. The distributions of mean PDR Peak values were compared between TFS (transplant free survival) and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: Days 1 and 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Mean Peak PDR for TFS subjects at Day 21 | Mean Peak PDR for non-TFS subjects at Day 21 | |
| 13C-Methacetin Breath Test (MBT) | 10.2 | 1.9 |
This outcome is similar to the peak PDR defined in the primary outcome but as a secondary we are looking at Day 1 or Day 2 peak PDR values. Peak PDR is the maximal percent dose recovery (PDR) rate which reflects the maximum rate of metabolism of 13C-methacetin measured as the change in 13CO2 / 12CO2 ratio after ingestion of 13C-methacetin normalized using the patient's height and weight. The distributions of mean PDR Peak values were compared between TFS and non-TFS (death/transplant) at Day 21. (NCT02786836)
Timeframe: The first MBT reading either on Day 1 or Day 2 and Day 21
| Intervention | percentage per hour (Mean) | |
|---|---|---|
| Day 1 or 2 MBT & Day 21 TFS | Day 1 or 2 MBT & Day 21 non-TFS | |
| 13C-Methacetin Breath Test (MBT) | 9.1 | 2.3 |
1 trial available for methacetin and Pregnancy
| Article | Year |
|---|---|
Point-of-care continuous (13)C-methacetin breath test improves decision making in acute liver disease: results of a pilot clinical trial.
Topics: Acetamides; Acute Disease; Adolescent; Adult; Breath Tests; Carbon Isotopes; Female; Hepatitis; Hepa | 2009 |
4 other studies available for methacetin and Pregnancy
| Article | Year |
|---|---|
Is the [15N]methacetin liver function test suited to estimate environmental effects on the maturity of neonates?
Topics: Acetamides; Female; Humans; Infant, Newborn; Infant, Small for Gestational Age; Liver; Maternal Expo | 1994 |
Influence of intrauterine growth retardation on parameters of liver function in low birth weight infants.
Topics: Acetamides; Amines; Bile Acids and Salts; Female; Fetal Growth Retardation; Humans; Infant; Infant N | 1990 |
Nuclear medicine liver function tests for pregnant women and children. 1. Breath tests with 14C-methacetin and 13C-methacetin.
Topics: Acetamides; Breath Tests; Carbon Isotopes; Carbon Radioisotopes; Child; Female; Humans; Liver; Liver | 1985 |
Nuclear medicine liver-function tests for pregnant women and children. 2. A new test method via urine using 15N-methacetin.
Topics: Acetamides; Adolescent; Adult; Breath Tests; Child; Child, Preschool; Female; Humans; Infant; Liver | 1985 |