metformin has been researched along with Vitamin B 12 Deficiency in 129 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Vitamin B 12 Deficiency: A nutritional condition produced by a deficiency of VITAMIN B 12 in the diet, characterized by megaloblastic anemia. Since vitamin B 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations. A wide variety of neuropsychiatric abnormalities is also seen in vitamin B 12 deficiency and appears to be due to an undefined defect involving myelin synthesis. (From Cecil Textbook of Medicine, 19th ed, p848)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Total, but not bioavailable, vitamin B12 stores were depleted during pregnancy to a greater extent in metformin-treated than in insulin-treated women with GDM, but neither analyte differed between groups at any stage." | 9.17 | Vitamin B12 and homocysteine status during pregnancy in the metformin in gestational diabetes trial: responses to maternal metformin compared with insulin treatment. ( Baghurst, PA; Coat, S; Gatford, KL; Hague, WM; Houda, CM; Lu, ZX; Owens, JA; Rowan, JA; Sikaris, K, 2013) |
| "To study the effects of metformin use and vitamin B12 deficiency on stroke rate among patients with T2DM." | 8.31 | The Effect of Metformin on Vitamin B12 Deficiency and Stroke. ( Abu Dahoud, W; Blum, A; Hajouj, T; Horrany, N; Moallem, Y; Zreik, M, 2023) |
| "To determine the impact of hyperglycemia and metformin use on relevant B vitamin biomarkers and cognitive outcomes in older adults." | 7.91 | Hyperglycemia and Metformin Use Are Associated With B Vitamin Deficiency and Cognitive Dysfunction in Older Adults. ( Casey, MC; Cunningham, C; Gallagher, AM; Hoey, L; Hughes, CF; Laird, E; McCann, A; McCarroll, K; McNulty, H; Molloy, AM; O'Kane, M; Porter, KM; Strain, S; Tracey, F; Ward, M, 2019) |
| "Aim of the study was to clarify the relationship between metformin-induced vitamin B12 (B12) deficiency, hyperhomocysteinemia and vascular complications in patients with type 2 diabetes." | 7.79 | Relationship between metformin use, vitamin B12 deficiency, hyperhomocysteinemia and vascular complications in patients with type 2 diabetes. ( Aizawa, T; Funase, Y; Ouchi, K; Sato, Y; Yamauchi, K, 2013) |
| "Vitamin B12 deficiency may be induced by long-term use of metformin, which may in turn lead to hyperhomocysteinemia." | 7.74 | Hyperhomocysteinemia, deep vein thrombosis and vitamin B12 deficiency in a metformin-treated diabetic patient. ( Chang, CS; Chung, CY; Lin, HY; Lin, JS; Shen, MC; Wang, ML, 2007) |
| "However, the associated vitamin B12 deficiency is less well known." | 5.40 | Long term use of metformin leading to vitamin B 12 deficiency. ( Tan, LK; Tung, ML, 2014) |
| "Long-term use of metformin in DPPOS was associated with biochemical B12 deficiency and anemia." | 5.22 | Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study. ( Aroda, VR; Bray, GA; Crandall, JP; Edelstein, SL; Goldberg, RB; Knowler, WC; Marcovina, SM; Orchard, TJ; Schade, DS; Temprosa, MG; White, NH, 2016) |
| "Total, but not bioavailable, vitamin B12 stores were depleted during pregnancy to a greater extent in metformin-treated than in insulin-treated women with GDM, but neither analyte differed between groups at any stage." | 5.17 | Vitamin B12 and homocysteine status during pregnancy in the metformin in gestational diabetes trial: responses to maternal metformin compared with insulin treatment. ( Baghurst, PA; Coat, S; Gatford, KL; Hague, WM; Houda, CM; Lu, ZX; Owens, JA; Rowan, JA; Sikaris, K, 2013) |
| "To study the effects of metformin use and vitamin B12 deficiency on stroke rate among patients with T2DM." | 4.31 | The Effect of Metformin on Vitamin B12 Deficiency and Stroke. ( Abu Dahoud, W; Blum, A; Hajouj, T; Horrany, N; Moallem, Y; Zreik, M, 2023) |
| " Metabolic syndrome and polycystic ovary syndrome diagnosed patients with insulin resistance and/or impaired glucose tolerance, patients with type 2 diabetes mellitus (DM) treated with metformin were enrolled in study." | 4.12 | Does Metformin Treatment in Pediatric Population Cause Vitamin B12 Deficiency? ( Berberoglu, M; Dogan, O; Eminoglu, FT; Kontbay, T; Kose, E; Siklar, Z; Taş, Ö; Tumer, L, 2022) |
| "To examine (1) effects of short-term metformin treatment on serum holotranscobalamin (holoTC) and folate and (2) their association with insulin sensitivity in recent-onset type 2 diabetes." | 3.96 | Vitamin B12 and Folate Concentrations in Recent-onset Type 2 Diabetes and the Effect of Metformin Treatment. ( Anadol-Schmitz, E; Bobrov, P; Burkart, V; Kahl, S; Kanti, G; Karusheva, Y; Markgraf, DF; Roden, M; Sarabhai, T; Strassburger, K; Szendroedi, J; Trenkamp, S; Zaharia, OP; Ziegler, D, 2020) |
| "To determine the impact of hyperglycemia and metformin use on relevant B vitamin biomarkers and cognitive outcomes in older adults." | 3.91 | Hyperglycemia and Metformin Use Are Associated With B Vitamin Deficiency and Cognitive Dysfunction in Older Adults. ( Casey, MC; Cunningham, C; Gallagher, AM; Hoey, L; Hughes, CF; Laird, E; McCann, A; McCarroll, K; McNulty, H; Molloy, AM; O'Kane, M; Porter, KM; Strain, S; Tracey, F; Ward, M, 2019) |
| "001, 95% CI) with age, dementia, changes in blood red cell counts, memory, and with the taking of metformin and proton pump inhibitors (P=." | 3.88 | [Vitamin B ( Camarero-Shelly, M, 2018) |
| "Metformin, a biguanide drug, is emerging as an important treatment option for the prevention or treatment of weight gain, type 2 diabetes mellitus, and the metabolic syndrome in psychiatric patients, especially those who require or receive antipsychotic drugs." | 3.83 | Use of Metformin for Cardiometabolic Risks in Psychiatric Practice: Need-to-Know Safety Issues. ( Andrade, C, 2016) |
| "Aim of the study was to clarify the relationship between metformin-induced vitamin B12 (B12) deficiency, hyperhomocysteinemia and vascular complications in patients with type 2 diabetes." | 3.79 | Relationship between metformin use, vitamin B12 deficiency, hyperhomocysteinemia and vascular complications in patients with type 2 diabetes. ( Aizawa, T; Funase, Y; Ouchi, K; Sato, Y; Yamauchi, K, 2013) |
| "Vitamin B12 deficiency may be induced by long-term use of metformin, which may in turn lead to hyperhomocysteinemia." | 3.74 | Hyperhomocysteinemia, deep vein thrombosis and vitamin B12 deficiency in a metformin-treated diabetic patient. ( Chang, CS; Chung, CY; Lin, HY; Lin, JS; Shen, MC; Wang, ML, 2007) |
| "Identification of risk factors for metformin-related vitamin B(12) deficiency has major potential implications regarding the management of diabetes mellitus." | 3.73 | Risk factors of vitamin B(12) deficiency in patients receiving metformin. ( Chan, MH; Chow, KM; Ma, KK; Szeto, CC; Ting, RZ, 2006) |
| "Type 2 diabetes mellitus is one of the most globally common chronic diseases." | 3.01 | Metformin-Induced Vitamin B12 Deficiency among Type 2 Diabetes Mellitus' Patients: A Systematic Review. ( Abuzaid, O; Al-Sheikh, R; Albannawi, M; Alhajjmohammed, D; Alkubaish, Z; Althani, R; Altheeb, L; Altuwajiry, H; Ayoub, H; Khattab, R; Mutwalli, H; Purayidathil, T, 2023) |
| "390 patients with type 2 diabetes receiving treatment with insulin." | 2.75 | Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. ( Bets, D; de Jager, J; Donker, AJ; Kooy, A; Lehert, P; Stehouwer, CD; van der Kolk, J; Verburg, J; Wulffelé, MG, 2010) |
| "Metformin treatment is a known pharmacological cause of vitamin B12 (Cbl) deficiency with controversial responsible mechanisms." | 2.48 | Recommendations for diagnosis and management of metformin-induced vitamin B12 (Cbl) deficiency. ( Mazokopakis, EE; Starakis, IK, 2012) |
| "Successful care of the patient with type 2 diabetes requires not only focus on glucose management but also on comorbidities such as hypertension, dyslipidemia and obesity which are closely linked to microvascular and macrovascular complications." | 2.47 | Recent diabetes issues affecting the primary care clinician. ( Barboza, J; Sando, KR; Taylor, J; Willis, C, 2011) |
| " Due to a lack of means, the dosage of homocysteine and methylmalonic acid had not been carried out to confirm the vitamin B12 deficiency in the patient whose level was less than 200ng/mL." | 1.91 | [Cross-Sectional Study on Adverse Effects of Metformin Hydrochloride on 130 Patients Type 2 Diabetic Admitted to Medical Center and Diabetes Home of Sidi Bel-Abbès]. ( Belakhdar, K; Kraroubi, A; Matmour, D; Sakouhi, M, 2023) |
| "High daily dosage (≥1500 mg/day) played an important role in metformin-associated vitamin B12 deficiency while not contributing to the risk of PN." | 1.91 | The effects of daily dose and treatment duration of metformin on the prevalence of vitamin B12 deficiency and peripheral neuropathy in Chinese patients with type 2 diabetes mellitus: A multicenter cross-sectional study. ( Bi, Y; Chen, S; Gao, L; Ji, L; Lei, M; Liu, F; Liu, X; Lu, Y; Ran, X; Shen, X; Su, Q; Wang, Y; Zhao, D, 2023) |
| "The prevalence of vitamin B12 deficiency among T2DM patients on metformin treatment in this study was high (48." | 1.91 | Prevalence of vitamin B12 deficiency in type 2 diabetic patients taking metformin, a cross-sectional study in primary healthcare. ( Al Quran, T; Al-Momani, R; Allan, H; Alsaleh, M; Aqel, HT; Bataineh, Z; Khader, A, 2023) |
| "45 (93." | 1.91 | Does Metformin in Different Doses Cause Vitamin B12 Deficiency? A cross-Sectional Study. ( Mohammed Ismail, S, 2023) |
| "To describe the prevalence of vitamin B12 deficiency among Jordanian patients with type 2 diabetes mellitus treated with metformin and to compare the findings with those who did not receive metformin." | 1.72 | Influence of metformin intake on serum vitamin B12 levels in patients with type 2 diabetes mellitus. ( Al-Fawaeir, S; Al-Odat, I, 2022) |
| "Vitamin B12 deficiency was classified based on the Fedosov age-normalized wellness quotient." | 1.62 | Profiling immuno-metabolic mediators of vitamin B12 deficiency among metformin-treated type 2 diabetic patients in Ghana. ( Afranie, BO; Amoani, B; Boakye, D; Dadzie, RE; Kwarteng, A; Laing, EF; Mantey, R; Opoku, S; Owiredu, EW; Sakyi, SA, 2021) |
| "Our findings show a low prevalence of vitamin B12 deficiency in type 2 diabetic patients taking metformin." | 1.62 | Vitamin B12 deficiency in patients with type 2 diabetes mellitus using metformin and the associated factors in Saudi Arabia. ( Al Saeed, RR; Baraja, MA, 2021) |
| "The prevalence of vitamin B12 deficiency is considerable among diabetic patients on metformin therapy." | 1.56 | Vitamin B12 Deficiency in Diabetic Patients on Metformin Therapy: A cross-sectional study from Oman. ( Al Mahrezi, AM; Al-Gahhafi, M; Al-Hamdi, A; Al-Mamari, A; Al-Roshdi, S; Jaju, S, 2020) |
| "The diagnosis of vitamin B12 deficiency due to long-term metformin was suspected while excluding other potential causes." | 1.56 | [Oral diagnosis of vitamin B12 deficiency due to long-term metformin treatment: a case report]. ( Attiya, N, 2020) |
| "Vitamin B12 deficiency was recorded at ≤187 pg/ml." | 1.51 | Vitamin B12 status and peripheral neuropathy in patients with type 2 diabetes mellitus. ( Ashor, AW; Khalaf, KM; Khudhair, MS, 2019) |
| "Serum vitamin B12 deficiency occurred in 22." | 1.51 | Association between metformin dose and vitamin B12 deficiency in patients with type 2 diabetes. ( Ahn, CW; Fang, S; Kim, J; Lee, HS; Park, JS, 2019) |
| "To compare the prevalence of vitamin B12 deficiency and peripheral neuropathy between two groups of type 2 diabetes mellitus (T2DM) patients treated with or without metformin, and to determine factors associated with vitamin B12 deficiency therapy and dietary intake of vitamin B12." | 1.48 | The association of metformin use with vitamin B12 deficiency and peripheral neuropathy in Saudi individuals with type 2 diabetes mellitus. ( Abdelhay, O; Abuhaimed, SN; Al-Asmari, AK; AlHarbi, NG; Alharbi, TJ; Alkhashan, HI; AlRasheed, AN; Bin Rsheed, AM; Mohammed, N; Tourkmani, AM, 2018) |
| "Assessment of the impact of type 2 diabetes (T2DM) and metformin use on vitamin B12 (VB12) associated biomarkers and their suitability to represent VB12 supply." | 1.48 | Impact of type 2 Diabetes and Metformin use on Vitamin B12 Associated Biomarkers - an Observational Study. ( Hersberger, KE; Metaxas, C; Rudofsky, G; Walter, PN; Zurwerra, C, 2018) |
| "Metformin treatment is associated with a decrease of serum vitamin B12, but whether this reflects tissue B12 deficiency is controversial." | 1.48 | Long-term treatment with metformin in type 2 diabetes and methylmalonic acid: Post hoc analysis of a randomized controlled 4.3year trial. ( Kooy, A; Lehert, P; Out, M; Schalkwijk, CA; Stehouwer, CDA, 2018) |
| "Veterans 50 years or older with either type 2 diabetes and long-term metformin therapy (n = 3,687) or without diabetes and no prescription for metformin (n = 13,258)." | 1.46 | Long-term Metformin Therapy and Monitoring for Vitamin B12 Deficiency Among Older Veterans. ( Elliott, JL; Holland, NW; Johnson, TM; Kancherla, V; Khakharia, A; Oakley, GP; Patel, BB; Phillips, LS; Vaughan, CP, 2017) |
| "Clinical and laboratory data of type 2 diabetes mellitus patients whose vitamin B12 status was evaluated in the last decade (2005 - 2016) were analyzed." | 1.46 | [Vitamin B12 Deficiency in Type 2 Diabetes Mellitus]. ( Azinheira, J; Capitão, RM; Sequeira Duarte, J; Tavares Bello, C; Vasconcelos, C, 2017) |
| "469 ambulatory type 2 diabetes patients (mean diabetes duration 10." | 1.46 | Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes. ( Fleischer, J; Hansen, CS; Jensen, JS; Jørgensen, ME; Ridderstråle, M; Vistisen, D, 2017) |
| "Current evidence linking vitamin B12 deficiency with metformin use is inconsistent." | 1.46 | Metformin Use and Vitamin B12 Deficiency: Untangling the Association. ( Elizondo-Plazas, A; González-González, JG; González-Velázquez, C; Montes-Villarreal, J; Rodríguez-Gutiérrez, R; Rodríguez-Velver, KV; Salcido-Montenegro, A, 2017) |
| "The prevalence of vitamin B12 deficiency (defined by concentrations <150 pmol/L) was determined." | 1.43 | Vitamin B12 deficiency in metformin-treated type-2 diabetes patients, prevalence and association with peripheral neuropathy. ( Ahmed, MA; Muntingh, G; Rheeder, P, 2016) |
| " Long-term use of metformin has been associated with subsequent reductions in vitamin B12 concentrations." | 1.43 | Multivitamin Use and Serum Vitamin B12 Concentrations in Older-Adult Metformin Users in REGARDS, 2003-2007. ( Cashion, WT; Garn, JV; Judd, SE; Kancherla, V; Oakley, GP; Odewole, O; Williamson, RS; Zakai, NA, 2016) |
| "In an observational study, among 550 type 2 diabetes patients using metformin, cobalamin and holotranscobalamin (holoTCII) levels were measured at the annual diabetes checkup, and deficiencies were defined as <148 and <21 pmol/L, respectively." | 1.42 | Cobalamin status and its relation with depression, cognition and neuropathy in patients with type 2 diabetes mellitus using metformin. ( Beulens, JW; Biemans, E; Cuellar Renteria, VG; Hart, HE; Kooijman-Buiting, AM; Rutten, GE, 2015) |
| "This cross-sectional study among 550 type 2 diabetes patients using metformin (mean daily dose 1,306 mg; mean duration 64 months) was conducted in four primary care centers in Utrecht, the Netherlands." | 1.42 | Influence of duration and dose of metformin on cobalamin deficiency in type 2 diabetes patients using metformin. ( Beulens, JW; Hart, HE; Kooijman-Buiting, AM; Kuijs, R; Rutten, GE, 2015) |
| "However, the associated vitamin B12 deficiency is less well known." | 1.40 | Long term use of metformin leading to vitamin B 12 deficiency. ( Tan, LK; Tung, ML, 2014) |
| " Positive correlations were observed between B 12 concentration, age and dosage and duration of metformin treatment." | 1.40 | The prevalence of low vitamin B12 status in people with type 2 diabetes receiving metformin therapy in New Zealand--a clinical audit. ( Haeusler, S; Krebs, JD; Parry-Strong, A, 2014) |
| "The prevalence rates of vitamin B12 deficiency (<191 ng/L) were 27% and 12% in Europeans and Indians, respectively and higher in metformin treated type 2 diabetes patients." | 1.40 | Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes. ( Adaikalakoteswari, A; Anjana, RM; Gokulakrishnan, K; Jayashri, R; Kumar, S; McTernan, PG; Mohan, V; Patel, V; Pradeepa, R; Saravanan, P; Sukumar, N; Tripathi, G; Venkataraman, H, 2014) |
| "Vitamin B12 deficiency was defined as vitamin B12 ≤ 300 pg/mL without folate deficiency (folate > 4 ng/mL)." | 1.40 | Association of vitamin B12 deficiency and metformin use in patients with type 2 diabetes. ( Ahn, YB; Han, KD; Kim, HS; Ko, SH; Park, YM; Song, KH, 2014) |
| "The prevalence of vitamin B12 deficiency in the metformin-treated patients was significantly higher in the S+M group compared with the I+M group (17." | 1.40 | Higher prevalence of metformin-induced vitamin B12 deficiency in sulfonylurea combination compared with insulin combination in patients with type 2 diabetes: a cross-sectional study. ( Ahn, YB; Kang, D; Ko, SH; Lim, TS; Park, YM; Yun, JS, 2014) |
| "Metformin use was associated with impaired cognitive performance." | 1.39 | Increased risk of cognitive impairment in patients with diabetes is associated with metformin. ( Ames, D; Boundy, K; Brodaty, H; Bush, AI; Carne, RP; Ellis, KA; Faux, NG; Kotowicz, MA; Mander, AG; Martins, R; Moore, EM; Rowe, C; Szoeke, C; Watters, DA; Woodward, M, 2013) |
| "We enrolled 114 outdoor patients of type 2 diabetes mellitus currently on metformin for atleast 12 months, by consecutive sampling, and 105 age and sex matched patients taken as control." | 1.39 | Prevalence of vitamin B12 deficiency in patients of type 2 diabetes mellitus on metformin: a case control study from Pakistan. ( bin Usman, H; Iftikhar, R; Iqbal, Z; Kamran, SM; Qadir, A, 2013) |
| "Vitamin B12 deficiency was defined as serum B12 concentrations <150 pmol/l." | 1.39 | Vitamin B12 deficiency and the lack of its consequences in type 2 diabetes patients using metformin. ( Bilo, HJ; de Groot-Kamphuis, DM; Groenier, KH; Houweling, ST; Kleefstra, N; van Dijk, PR, 2013) |
| "Metformin has been available in the United States for approximately fifteen years." | 1.36 | Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy. ( Bell, DS, 2010) |
| "Metformin use was clearly associated with lower vitamin B12 levels." | 1.36 | Association between vitamin B12 levels and mortality in hospitalized older adults. ( Malnick, S; Shavit, Y; Stern, F; Tal, S, 2010) |
| "Metformin is an invaluable hypoglycaemic agent." | 1.33 | Metformin-related vitamin B12 deficiency. ( Dai, LK; Jean, W; Liu, KW, 2006) |
| "There were eight (14%) patients with vitamin B12 deficiency and three among them had hyperhomocysteinaemia." | 1.33 | [Factors influencing homocysteineamia in type 2 diabetic patients]. ( Bouzid, C; Essais, O; Ibrahim, H; Machghoul, S; Ouertani, H; Ouni, Z; Zidi, B, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (3.88) | 18.7374 |
| 1990's | 1 (0.78) | 18.2507 |
| 2000's | 23 (17.83) | 29.6817 |
| 2010's | 68 (52.71) | 24.3611 |
| 2020's | 32 (24.81) | 2.80 |
| Authors | Studies |
|---|---|
| Taş, Ö | 1 |
| Kontbay, T | 1 |
| Dogan, O | 1 |
| Kose, E | 1 |
| Berberoglu, M | 1 |
| Siklar, Z | 1 |
| Tumer, L | 1 |
| Eminoglu, FT | 1 |
| Khattab, R | 1 |
| Albannawi, M | 1 |
| Alhajjmohammed, D | 1 |
| Alkubaish, Z | 1 |
| Althani, R | 1 |
| Altheeb, L | 1 |
| Ayoub, H | 1 |
| Mutwalli, H | 1 |
| Altuwajiry, H | 1 |
| Al-Sheikh, R | 1 |
| Purayidathil, T | 1 |
| Abuzaid, O | 1 |
| Bell, DSH | 1 |
| Alhaji, JH | 1 |
| Pratama, S | 1 |
| Lauren, BC | 1 |
| Wisnu, W | 1 |
| Ciftel, S | 1 |
| Bilen, A | 1 |
| Yanıkoglu, ND | 1 |
| Mercantepe, F | 1 |
| Dayanan, R | 1 |
| Ciftel, E | 1 |
| Capoglu, I | 1 |
| Kasalı, K | 1 |
| Bilen, H | 1 |
| Sakouhi, M | 3 |
| Matmour, D | 3 |
| Belakhdar, K | 3 |
| Kraroubi, A | 3 |
| Al-Fawaeir, S | 1 |
| Al-Odat, I | 1 |
| Yao, L | 1 |
| Wang, Y | 2 |
| Qin, S | 1 |
| Zhu, S | 1 |
| Wu, L | 1 |
| Horrany, N | 1 |
| Abu Dahoud, W | 1 |
| Moallem, Y | 1 |
| Hajouj, T | 1 |
| Zreik, M | 1 |
| Blum, A | 1 |
| Wee, AKH | 1 |
| Sultana, R | 1 |
| Mohammed Ismail, S | 1 |
| Dinesh, D | 1 |
| Lee, JS | 1 |
| Scott, TM | 1 |
| Tucker, KL | 1 |
| Palacios, N | 1 |
| Gao, L | 1 |
| Ran, X | 1 |
| Liu, X | 1 |
| Shen, X | 1 |
| Chen, S | 1 |
| Liu, F | 1 |
| Zhao, D | 1 |
| Bi, Y | 1 |
| Su, Q | 1 |
| Lu, Y | 1 |
| Lei, M | 1 |
| Ji, L | 1 |
| Jin, HY | 1 |
| Lee, KA | 1 |
| Kim, YJ | 1 |
| Gwak, IS | 1 |
| Park, TS | 1 |
| Yeom, SW | 1 |
| Kim, JS | 1 |
| Chen, M | 1 |
| Shu, Y | 1 |
| Li, Q | 1 |
| Kang, Z | 1 |
| Liu, T | 1 |
| Zhou, H | 1 |
| Huang, W | 1 |
| Zhang, W | 1 |
| Hussein Abed, H | 1 |
| Mousa Ali, A | 1 |
| Ghdhban Al-Ziaydi, A | 1 |
| Hurley-Kim, K | 1 |
| Vu, CH | 1 |
| Dao, NM | 1 |
| Tran, LC | 1 |
| McBane, S | 1 |
| Lee, J | 1 |
| Sepassi, A | 1 |
| Al Quran, T | 1 |
| Khader, A | 1 |
| Allan, H | 1 |
| Al-Momani, R | 1 |
| Aqel, HT | 1 |
| Alsaleh, M | 1 |
| Bataineh, Z | 1 |
| Khalaf, KM | 1 |
| Khudhair, MS | 1 |
| Ashor, AW | 1 |
| Herbert, L | 1 |
| Ribar, A | 1 |
| Mitchell, S | 1 |
| Phillips, C | 1 |
| Kim, J | 1 |
| Ahn, CW | 1 |
| Fang, S | 1 |
| Lee, HS | 1 |
| Park, JS | 1 |
| Lafaurie, M | 1 |
| Montastruc, F | 1 |
| Sugawara, K | 1 |
| Okada, Y | 1 |
| Hirota, Y | 1 |
| Sakaguchi, K | 1 |
| Ogawa, W | 1 |
| Cherulil, SJ | 1 |
| Chafekar, ND | 1 |
| Babaliche, P | 1 |
| Bhattacharyya, A | 1 |
| Das, SL | 1 |
| Basu, DA | 1 |
| Al-Hamdi, A | 1 |
| Al-Gahhafi, M | 1 |
| Al-Roshdi, S | 1 |
| Jaju, S | 1 |
| Al-Mamari, A | 1 |
| Al Mahrezi, AM | 1 |
| Kanti, G | 1 |
| Anadol-Schmitz, E | 1 |
| Bobrov, P | 1 |
| Strassburger, K | 1 |
| Kahl, S | 1 |
| Zaharia, OP | 1 |
| Sarabhai, T | 1 |
| Karusheva, Y | 1 |
| Burkart, V | 1 |
| Markgraf, DF | 1 |
| Trenkamp, S | 1 |
| Ziegler, D | 1 |
| Szendroedi, J | 1 |
| Roden, M | 1 |
| Shivaprasad, C | 1 |
| Gautham, K | 1 |
| Ramdas, B | 1 |
| Gopaldatta, KS | 1 |
| Nishchitha, K | 1 |
| Gökışık, MT | 1 |
| Uyar, S | 1 |
| Serra, MC | 1 |
| Kancherla, V | 3 |
| Khakharia, A | 2 |
| Allen, LL | 1 |
| Phillips, LS | 2 |
| Rhee, MK | 1 |
| Wilson, PWF | 1 |
| Vaughan, CP | 2 |
| D'Agostino, S | 1 |
| Limongelli, L | 1 |
| Favia, G | 1 |
| Dolci, M | 1 |
| Al Saeed, RR | 1 |
| Baraja, MA | 1 |
| Attiya, N | 1 |
| Sakyi, SA | 1 |
| Laing, EF | 1 |
| Mantey, R | 1 |
| Kwarteng, A | 1 |
| Owiredu, EW | 1 |
| Dadzie, RE | 1 |
| Amoani, B | 1 |
| Opoku, S | 1 |
| Afranie, BO | 1 |
| Boakye, D | 1 |
| Camarero-Shelly, M | 1 |
| Rodríguez-Gutiérrez, R | 1 |
| Montes-Villarreal, J | 1 |
| Rodríguez-Velver, KV | 1 |
| González-Velázquez, C | 1 |
| Salcido-Montenegro, A | 1 |
| Elizondo-Plazas, A | 1 |
| González-González, JG | 1 |
| Out, M | 1 |
| Kooy, A | 2 |
| Lehert, P | 2 |
| Schalkwijk, CA | 1 |
| Stehouwer, CDA | 1 |
| Crandall, JP | 2 |
| Tavares Bello, C | 1 |
| Capitão, RM | 1 |
| Sequeira Duarte, J | 1 |
| Azinheira, J | 1 |
| Vasconcelos, C | 1 |
| Metaxas, C | 1 |
| Zurwerra, C | 1 |
| Rudofsky, G | 1 |
| Hersberger, KE | 1 |
| Walter, PN | 1 |
| Ströhle, A | 1 |
| Obeid, R | 2 |
| Miller, JW | 1 |
| Alharbi, TJ | 1 |
| Tourkmani, AM | 1 |
| Abdelhay, O | 1 |
| Alkhashan, HI | 1 |
| Al-Asmari, AK | 1 |
| Bin Rsheed, AM | 1 |
| Abuhaimed, SN | 1 |
| Mohammed, N | 1 |
| AlRasheed, AN | 1 |
| AlHarbi, NG | 1 |
| Mendonça, FM | 1 |
| Leitão, MJ | 1 |
| Faria-Costa, G | 1 |
| Pires Da Rosa, G | 1 |
| Almeida, J | 1 |
| Porter, KM | 1 |
| Ward, M | 1 |
| Hughes, CF | 1 |
| O'Kane, M | 1 |
| Hoey, L | 1 |
| McCann, A | 1 |
| Molloy, AM | 1 |
| Cunningham, C | 1 |
| Casey, MC | 1 |
| Tracey, F | 1 |
| Strain, S | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective Study on Diabetes Mellitus and Its Complications in Newly Diagnosed Adult Patients[NCT01055093] | 2,000 participants (Anticipated) | Observational | 2005-09-30 | Recruiting | |||
| Study of Metformin HCL in Patients With Type 2 Diabetes Intensively Treated With Insulin: a Treatment Strategy for Insulin Resistance in Type 2 Diabetes Mellitus: a Randomized Controlled Trial[NCT00375388] | Phase 3 | 400 participants | Interventional | 1998-01-31 | Completed | ||
| Efficacy Study of Folic Acid Supplementation on Homocysteine Levels in Adolescent Epileptics Taking Antiepileptic Drugs: A Single Blind Randomized Controlled Clinical Trial[NCT02318446] | Phase 3 | 36 participants (Anticipated) | Interventional | 2015-03-31 | Not yet recruiting | ||
| Diabetes Prevention Program Outcomes Study[NCT00038727] | Phase 3 | 2,779 participants (Actual) | Interventional | 2002-09-30 | Active, not recruiting | ||
| Phase II Randomized Study of Neoadjuvant Metformin Plus Letrozole vs Placebo Plus Letrozole for ER-positive Postmenopausal Breast Cancer[NCT01589367] | Phase 2 | 208 participants (Actual) | Interventional | 2012-05-31 | Completed | ||
| Cross-sectional Study of the Association of Muscle Strength, Tinetti Test (POMA) Scores and Other Predictor Variables With Serum Vitamin Levels (Vitamin B12, Vitamin D and Folate) in Elderly Patients With Type 2 Diabetes Mellitus[NCT03376490] | 56 participants (Actual) | Observational | 2012-01-01 | Completed | |||
| A Randomized Trial of Metformin as Adjunct Therapy for Overweight Adolescents With Type 1 Diabetes[NCT01881828] | Phase 3 | 164 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| The Benefits of Vitamin B Combination as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient: Randomized Clinical Trial[NCT04689971] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2020-11-03 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Primary outcome for years 2002-2008 defined according to American Diabetes Association criteria (fasting plasma glucose level >= 126 mg/dL [7.0 mmol/L] or 2-hour plasma glucose >= 200 mg/dL [11.1 mmol/L], after a 75 gram oral glucose tolerance test (OGTT), and confirmed with a repeat test). (NCT00038727)
Timeframe: Outcomes were assessed from 1996-2008 (approximately 12 years including 6 years of DPP).
| Intervention | diabetes incidence (cases per 100 person (Number) |
|---|---|
| 1 Original Lifestyle | 5.3 |
| 2 Original Metformin | 6.4 |
| 3 Original Placebo | 7.8 |
All cause-mortality through clinic reports and National Death Index search (NCT00038727)
Timeframe: Outcomes were assessed throughout follow-up from 1996 to 2022. National Death Index search conducted in 2019 using early release data as of Dec 2018.
| Intervention | Participants (Count of Participants) |
|---|---|
| 1 Original Lifestyle | 158 |
| 2 Original Metformin | 152 |
| 3 Original Placebo | 143 |
Aggregate microvascular disease is defined as the average prevalence of 3 components: (1) retinopathy measured by photography (ETDRS of 20 or greater); (2) neuropathy detected by Semmes Weinstein 10 gram monofilament, and (3) nephropathy based on estimated glomerular filtration rate (eGFR by chronic kidney disease (CKD-Epi) equation ) (<45 ml/min, confirmed) and albumin-to-creatinine ratio in spot urine (> 30mg/gm, confirmed). (NCT00038727)
Timeframe: Outcomes were assessed from 2012-2013 (approximately 2 years).
| Intervention | average percentage of participants (Number) |
|---|---|
| 1 Original Lifestyle | 11.3 |
| 2 Original Metformin | 13 |
| 3 Original Placebo | 12.4 |
Measured using coronary artery calcification (CAC). (NCT00038727)
Timeframe: Outcomes were assessed from 2012-2013 (approximately 2 years).
| Intervention | CAC geometric mean in AU (Geometric Mean) | |
|---|---|---|
| Men | Women | |
| 1 Original Lifestyle | 70.1 | 6.0 |
| 2 Original Metformin | 40.2 | 6.1 |
| 3 Original Placebo | 63.7 | 5.3 |
Change in percent body fat (NCT01881828)
Timeframe: 0-26 weeks
| Intervention | percentage of change (Mean) |
|---|---|
| Metformin | -0 |
| Oral Placebo | 1 |
(NCT01881828)
Timeframe: 0-26 weeks
| Intervention | percentile (Mean) |
|---|---|
| Metformin | -1 |
| Oral Placebo | 1 |
(NCT01881828)
Timeframe: 0-26 weeks
| Intervention | insulin per kg (Mean) |
|---|---|
| Metformin | -0.1 |
| Oral Placebo | -0.0 |
(NCT01881828)
Timeframe: 0-26 weeks
| Intervention | centimeters (Mean) |
|---|---|
| Metformin | -0 |
| Oral Placebo | 1 |
(NCT01881828)
Timeframe: 0-26 weeks
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Change in Systolic | Change in Diastolic | |
| Metformin | 0 | 0 |
| Oral Placebo | -0 | 0 |
Hemoglobin A1c is a measure of glycemic control over approximately the past 3 months (NCT01881828)
Timeframe: 0-26 weeks
| Intervention | percentage (Mean) | |
|---|---|---|
| HbA1c | Change from Baseline to 26 Weeks | |
| Metformin | 9.0 | 0.2 |
| Oral Placebo | 8.9 | 0.2 |
Hemoglobin A1c is a measure of glycemic control over approximately the past 3 months (NCT01881828)
Timeframe: 0-26 weeks
| Intervention | percentage of participants (Number) | ||
|---|---|---|---|
| HbA1c Decrease ≥0.5% | HbA1c Increase ≥0.5% | HbA1c <7.5% | |
| Metformin | 19 | 44 | 3 |
| Oral Placebo | 18 | 35 | 4 |
(NCT01881828)
Timeframe: 0-26 weeks
| Intervention | mg/dL (Mean) | ||||
|---|---|---|---|---|---|
| Change in LDL | Change in VLDL | Change in HDL | Change in Triglycerides | Change in Total Cholesterol | |
| Metformin | -6 | -0 | -0 | 4 | -5 |
| Oral Placebo | 2 | 1 | -1 | 6 | 3 |
11 reviews available for metformin and Vitamin B 12 Deficiency
| Article | Year |
|---|---|
Metformin-Induced Vitamin B12 Deficiency among Type 2 Diabetes Mellitus' Patients: A Systematic Review.
Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Vitamin B 12; Vitamin B 12 Defici | 2023 |
Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes.
Topics: Aged; Calcium; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Peripheral Nervous | 2022 |
Vitamin B12 Deficiency in Patients with Diabetes on Metformin: Arab Countries.
Topics: Arabs; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Vitamin B 12 Deficiency | 2022 |
The efficacy of vitamin B
Topics: Diabetes Mellitus, Type 2; Dietary Supplements; Homocysteine; Humans; Hypoglycemic Agents; Metformin | 2022 |
[Interest of a pharmacovigilance medical consultation: Example of metformin-induced-vitamin B12 deficiency].
Topics: Adverse Drug Reaction Reporting Systems; Aged; Anemia, Megaloblastic; Diabetes Mellitus, Type 2; Dru | 2019 |
Proton Pump Inhibitors, H2-Receptor Antagonists, Metformin, and Vitamin B-12 Deficiency: Clinical Implications.
Topics: Histamine H2 Antagonists; Homocysteine; Humans; Metformin; Methylmalonic Acid; Nutritional Status; P | 2018 |
The role of metformin on vitamin B12 deficiency: a meta-analysis review.
Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Treatment Outcome; Vitamin B 12; | 2015 |
Recent diabetes issues affecting the primary care clinician.
Topics: Adamantane; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV | 2011 |
Recommendations for diagnosis and management of metformin-induced vitamin B12 (Cbl) deficiency.
Topics: Humans; Hypoglycemic Agents; Metformin; Models, Biological; Practice Guidelines as Topic; Prevalence | 2012 |
[Adverse effect of biguanides].
Topics: Acidosis, Lactic; Biguanides; Diabetes Mellitus, Type 2; Gastrointestinal Diseases; Humans; Hypoglyc | 2002 |
Mecobalamin.
Topics: Aged; Alprostadil; Animals; Cobamides; Coenzymes; Diabetic Neuropathies; Drug Administration Routes; | 2008 |
5 trials available for metformin and Vitamin B 12 Deficiency
| Article | Year |
|---|---|
Vitamin B12 and homocysteine status during pregnancy in the metformin in gestational diabetes trial: responses to maternal metformin compared with insulin treatment.
Topics: Adult; Biomarkers; Cohort Studies; Diabetes, Gestational; Female; Homocysteine; Humans; Hyperhomocys | 2013 |
Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study.
Topics: Adult; Aged; Anemia; Diabetes Mellitus, Type 2; Female; Homocysteine; Humans; Hypoglycemic Agents; M | 2016 |
Vitamin B12 screening in metformin-treated diabetics in primary care: were elderly patients less likely to be tested?
Topics: Age Factors; Aged; Comorbidity; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Healthcare D | 2017 |
Sublingual vitamin B12 compared to intramuscular injection in patients with type 2 diabetes treated with metformin: a randomised trial.
Topics: Administration, Sublingual; Aged; Diabetes Mellitus, Type 2; Dietary Supplements; Female; Humans; Hy | 2016 |
Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial.
Topics: Aged; Diabetes Mellitus, Type 2; Female; Folic Acid; Homocysteine; Humans; Hypoglycemic Agents; Long | 2010 |
Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial.
Topics: Aged; Diabetes Mellitus, Type 2; Female; Folic Acid; Homocysteine; Humans; Hypoglycemic Agents; Long | 2010 |
Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial.
Topics: Aged; Diabetes Mellitus, Type 2; Female; Folic Acid; Homocysteine; Humans; Hypoglycemic Agents; Long | 2010 |
Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial.
Topics: Aged; Diabetes Mellitus, Type 2; Female; Folic Acid; Homocysteine; Humans; Hypoglycemic Agents; Long | 2010 |
113 other studies available for metformin and Vitamin B 12 Deficiency
| Article | Year |
|---|---|
Does Metformin Treatment in Pediatric Population Cause Vitamin B12 Deficiency?
Topics: Adolescent; Child; Diabetes Mellitus, Type 2; Female; Homocysteine; Humans; Male; Metabolic Syndrome | 2022 |
Safety update: metformin and vitamin B
Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Vitamin B 12; Vitamin B 12 Defici | 2022 |
Vitamin B12, folic acid, vitamin D, iron, ferritin, magnesium, and HbA1c levels in patients with diabetes mellitus and dental prosthesis.
Topics: Case-Control Studies; Dental Prosthesis; Diabetes Mellitus; Ferritins; Folic Acid; Glycated Hemoglob | 2022 |
[Cross-Sectional Study on Adverse Effects of Metformin Hydrochloride on 130 Patients Type 2 Diabetic Admitted to Medical Center and Diabetes Home of Sidi Bel-Abbès].
Topics: Acidosis, Lactic; Adult; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Drug-Related Side Effec | 2023 |
[Cross-Sectional Study on Adverse Effects of Metformin Hydrochloride on 130 Patients Type 2 Diabetic Admitted to Medical Center and Diabetes Home of Sidi Bel-Abbès].
Topics: Acidosis, Lactic; Adult; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Drug-Related Side Effec | 2023 |
[Cross-Sectional Study on Adverse Effects of Metformin Hydrochloride on 130 Patients Type 2 Diabetic Admitted to Medical Center and Diabetes Home of Sidi Bel-Abbès].
Topics: Acidosis, Lactic; Adult; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Drug-Related Side Effec | 2023 |
[Cross-Sectional Study on Adverse Effects of Metformin Hydrochloride on 130 Patients Type 2 Diabetic Admitted to Medical Center and Diabetes Home of Sidi Bel-Abbès].
Topics: Acidosis, Lactic; Adult; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Drug-Related Side Effec | 2023 |
Influence of metformin intake on serum vitamin B12 levels in patients with type 2 diabetes mellitus.
Topics: Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Middle A | 2022 |
The antidiabetic drug metformin aids bacteria in hijacking vitamin B12 from the environment through RcdA.
Topics: Animals; Caenorhabditis elegans; Diabetes Mellitus, Type 2; Escherichia coli; Humans; Hypoglycemic A | 2023 |
The Effect of Metformin on Vitamin B12 Deficiency and Stroke.
Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Ischemic Stroke; Metformin; Prospective Stud | 2023 |
Determinants of vitamin B12 deficiency in patients with type-2 diabetes mellitus - A primary-care retrospective cohort study.
Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Folic Acid; Humans; Hyp | 2023 |
Does Metformin in Different Doses Cause Vitamin B12 Deficiency? A cross-Sectional Study.
Topics: Cross-Sectional Studies; Diabetes Mellitus, Type 2; Humans; Metformin; Vitamin B 12; Vitamin B 12 De | 2023 |
Association between Acid-Lowering Agents, Metformin, and Vitamin B12 among Boston-Area Puerto Ricans.
Topics: Adult; Diabetes Mellitus, Type 2; Histamine; Histamine H2 Antagonists; Humans; Hypoglycemic Agents; | 2023 |
The effects of daily dose and treatment duration of metformin on the prevalence of vitamin B12 deficiency and peripheral neuropathy in Chinese patients with type 2 diabetes mellitus: A multicenter cross-sectional study.
Topics: Cross-Sectional Studies; Diabetes Mellitus, Type 2; Duration of Therapy; East Asian People; Humans; | 2023 |
Bidirectional association between diabetic peripheral neuropathy and vitamin B12 deficiency: Two longitudinal 9-year follow-up studies using a national sample cohort.
Topics: Cohort Studies; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Follow-Up Studies; Humans; Hypogly | 2023 |
Bacteroides ovatus accelerates metformin-induced vitamin B12 deficiency in type 2 diabetes patients by accumulating cobalamin.
Topics: Animals; Diabetes Mellitus, Type 2; Homocysteine; Humans; Metformin; Mice; Vitamin B 12; Vitamin B 1 | 2023 |
Evaluation level of serum vitamin B12 in Iraqi patients with diabetes mellitus type 2, who used the metformin drug as a hypoglycemic agent.
Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Iraq; Metformin; Vitamin B 12; Vitamin B 12 | 2023 |
Effect of Metformin Use on Vitamin B12 Deficiency Over Time (EMBER): A Real-World Evidence Database Study.
Topics: Adolescent; Adult; Aged; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Populati | 2023 |
Prevalence of vitamin B12 deficiency in type 2 diabetic patients taking metformin, a cross-sectional study in primary healthcare.
Topics: Cross-Sectional Studies; Diabetes Mellitus, Type 2; Humans; Metformin; Prevalence; Primary Health Ca | 2023 |
Vitamin B12 status and peripheral neuropathy in patients with type 2 diabetes mellitus.
Topics: Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Humans; Hypoglyce | 2019 |
Discovering metformin-induced vitamin B12 deficiency in patients with type 2 diabetes in primary care.
Topics: Adolescent; Adult; Aged; Checklist; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; | 2019 |
Association between metformin dose and vitamin B12 deficiency in patients with type 2 diabetes.
Topics: Age Factors; Aged; Alcohol Drinking; Anemia; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Dos | 2019 |
Relationship between metformin use and vitamin B
Topics: Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Erythrocyte Indices; Female; Hemoglobins; | 2020 |
Prevalence of Vitamin B12 Defi ciency and Clinical Neuropathy with Metformin Use in Type 2 Diabetes Mellitus Patients.
Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Prevalence; Vitamin B 12; Vitamin | 2020 |
Evaluation of Risk Factors of Peripheral Neuropathy in Type 2 Diabetes Mellitus Patients with Special Reference to Vitamin B12 Defi ciency.
Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Peripheral Nervous System Disease | 2020 |
Vitamin B12 Deficiency in Diabetic Patients on Metformin Therapy: A cross-sectional study from Oman.
Topics: Adult; Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents | 2020 |
Vitamin B12 and Folate Concentrations in Recent-onset Type 2 Diabetes and the Effect of Metformin Treatment.
Topics: Adolescent; Adult; Aged; Biomarkers; Blood Glucose; Cross-Sectional Studies; Diabetes Mellitus, Type | 2020 |
Metformin Usage Index and assessment of vitamin B12 deficiency among metformin and non-metformin users with type 2 diabetes mellitus.
Topics: Adult; Case-Control Studies; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Hu | 2020 |
The role of Helicobacter pylori in vitamin-B
Topics: Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Helicobacter Infections; Helicobac | 2020 |
Long-term metformin treatment and risk of peripheral neuropathy in older Veterans.
Topics: Aged; Alcoholism; Body Mass Index; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Humans; | 2020 |
Oral manifestation of vitamin B12 associated with metformin and proton pump inhibitors: oral signs of drug related hypovitaminosis.
Topics: Humans; Metformin; Pharmaceutical Preparations; Proton Pump Inhibitors; Vitamin B 12; Vitamin B 12 D | 2021 |
Vitamin B12 deficiency in patients with type 2 diabetes mellitus using metformin and the associated factors in Saudi Arabia.
Topics: Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; | 2021 |
[Oral diagnosis of vitamin B12 deficiency due to long-term metformin treatment: a case report].
Topics: Aged; Anemia; Diabetes Mellitus; Diagnosis, Oral; Female; Glossitis; Humans; Hypoglycemic Agents; Me | 2020 |
Profiling immuno-metabolic mediators of vitamin B12 deficiency among metformin-treated type 2 diabetic patients in Ghana.
Topics: Adult; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Ghana; Humans; Male; Metformin; Midd | 2021 |
[Vitamin B
Topics: Adult; Age Factors; Aged; Dementia; Female; Humans; Longitudinal Studies; Male; Mass Screening; Metf | 2018 |
Metformin Use and Vitamin B12 Deficiency: Untangling the Association.
Topics: Adolescent; Adult; Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypogly | 2017 |
Long-term treatment with metformin in type 2 diabetes and methylmalonic acid: Post hoc analysis of a randomized controlled 4.3year trial.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Diabetes Mellitus, Type 2; Female; Humans; Male; Metform | 2018 |
Metformin and vitamin B12-What's missing from this picture?
Topics: Humans; Hypoglycemic Agents; Metformin; Vitamin B 12; Vitamin B 12 Deficiency | 2018 |
[Vitamin B12 Deficiency in Type 2 Diabetes Mellitus].
Topics: Aged; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; | 2017 |
Impact of type 2 Diabetes and Metformin use on Vitamin B12 Associated Biomarkers - an Observational Study.
Topics: Aged; Biomarkers; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Male; Metformi | 2018 |
[In process].
Topics: Diabetes Mellitus, Type 2; Humans; Intestinal Absorption; Metformin; Predictive Value of Tests; Risk | 2016 |
The association of metformin use with vitamin B12 deficiency and peripheral neuropathy in Saudi individuals with type 2 diabetes mellitus.
Topics: Diabetes Mellitus, Type 2; Diet; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; | 2018 |
Chronic diarrhea: an unusual clinical presentation of vitamin B
Topics: Diabetes Mellitus, Type 1; Diarrhea; Humans; Male; Metformin; Middle Aged; Vitamin B 12; Vitamin B 1 | 2019 |
Hyperglycemia and Metformin Use Are Associated With B Vitamin Deficiency and Cognitive Dysfunction in Older Adults.
Topics: Aged; Aged, 80 and over; Cognitive Dysfunction; Cohort Studies; Female; Folic Acid; Geriatric Assess | 2019 |
Manifestation of beefy red tongue in a woman on metformin.
Topics: Female; Humans; Hypoglycemic Agents; Metformin; Middle Aged; Vitamin B 12 Deficiency | 2013 |
Increased risk of cognitive impairment in patients with diabetes is associated with metformin.
Topics: Aged; Aged, 80 and over; Calcium; Cognition Disorders; Diabetes Mellitus; Female; Humans; Logistic M | 2013 |
Relationship between metformin use, vitamin B12 deficiency, hyperhomocysteinemia and vascular complications in patients with type 2 diabetes.
Topics: Aged; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Retinopathy; Diet | 2013 |
Vitamin B12 deficiency and the lack of its consequences in type 2 diabetes patients using metformin.
Topics: Aged; Anemia; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Erythrocyte Indices; Female; Hemog | 2013 |
Metformin causing vitamin B12 deficiency: a guilty verdict without sufficient evidence.
Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Nutrition Surveys; Vitamin B 12 D | 2014 |
Long term use of metformin leading to vitamin B 12 deficiency.
Topics: Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Metformin; Vitamin B 12 Defici | 2014 |
Prevalence of vitamin B12 deficiency in patients of type 2 diabetes mellitus on metformin: a case control study from Pakistan.
Topics: Adult; Aged; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; M | 2013 |
Influence of duration and dose of metformin on cobalamin deficiency in type 2 diabetes patients using metformin.
Topics: Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; | 2015 |
[Vitamin B12 deficiency associated with high doses od metformin in older people diabetic].
Topics: Aged; Aged, 80 and over; Case-Control Studies; Diabetes Complications; Diabetes Mellitus; Female; Hu | 2014 |
Associations between medication use and homocysteine levels in an older population, and potential mediation by vitamin B12 and folate: data from the B-PROOF Study.
Topics: Aged; Diuretics; Female; Folic Acid; Health Services for the Aged; Homocysteine; Humans; Male; Metfo | 2014 |
A woman with macrocytic anaemia and confusion.
Topics: Aged, 80 and over; Anemia, Macrocytic; Confusion; Diagnosis, Differential; Female; Humans; Hypoglyce | 2014 |
Association of vitamin B12 deficiency and metformin use in patients with type 2 diabetes.
Topics: Aged; Area Under Curve; Diabetes Mellitus, Type 2; Female; Folic Acid; Humans; Hypoglycemic Agents; | 2014 |
BNF recommends hydroxocobalamin rather than cyanocobalamin for vitamin B12 deficiency.
Topics: Anemia, Macrocytic; Confusion; Female; Humans; Hypoglycemic Agents; Metformin; Vitamin B 12 Deficien | 2014 |
Author's reply to Charkin.
Topics: Anemia, Macrocytic; Confusion; Female; Humans; Hypoglycemic Agents; Metformin; Vitamin B 12 Deficien | 2014 |
Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes.
Topics: Adult; Aged; Aged, 80 and over; Asian People; Diabetes Mellitus, Type 2; Europe; Female; Humans; Hyp | 2014 |
Higher prevalence of metformin-induced vitamin B12 deficiency in sulfonylurea combination compared with insulin combination in patients with type 2 diabetes: a cross-sectional study.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Drug Combinations; Female; Folic Acid; Humans; Insulin; Male | 2014 |
Cobalamin status and its relation with depression, cognition and neuropathy in patients with type 2 diabetes mellitus using metformin.
Topics: Adult; Aged; Cognition; Depressive Disorder; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Femal | 2015 |
A safe and effective drug?
Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; New Zealand; Product Surveillance | 2014 |
The prevalence of low vitamin B12 status in people with type 2 diabetes receiving metformin therapy in New Zealand--a clinical audit.
Topics: Age Factors; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents | 2014 |
Metformin plus proton pump inhibitors therapy: the cobalamin deficiency challenge.
Topics: Aged; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Injections, Intramuscular; Male; Metfo | 2015 |
Diabetes: Metformin linked to vitamin B12 deficiency.
Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Vitamin B 12 Deficiency | 2016 |
The importance of ruling out risk factors for vitamin B12 deficiency induced by metformin in older patients
Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Vitamin B 12; Vitamin B 12 Defici | 2016 |
Multivitamin Use and Serum Vitamin B12 Concentrations in Older-Adult Metformin Users in REGARDS, 2003-2007.
Topics: Adult; Aged; Case-Control Studies; Diabetes Mellitus, Type 2; Dietary Supplements; Female; Humans; H | 2016 |
Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes.
Topics: Antihypertensive Agents; Autonomic Nervous System Diseases; Cardiovascular Diseases; Cohort Studies; | 2017 |
Vitamin B12 deficiency in metformin-treated type-2 diabetes patients, prevalence and association with peripheral neuropathy.
Topics: Aged; Black People; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic | 2016 |
Use of Metformin for Cardiometabolic Risks in Psychiatric Practice: Need-to-Know Safety Issues.
Topics: Acidosis, Lactic; Antipsychotic Agents; Cohort Studies; Diabetes Mellitus, Type 2; Gastrointestinal | 2016 |
Long-term Metformin Therapy and Monitoring for Vitamin B12 Deficiency Among Older Veterans.
Topics: Diabetes Mellitus, Type 2; Female; Hospitals, Veterans; Humans; Hypoglycemic Agents; Male; Metformin | 2017 |
Metformin, B12 and homocysteine levels: the plausible cause or effect?
Topics: Homocysteine; Humans; Hyperhomocysteinemia; Metformin; Venous Thrombosis; Vitamin B 12; Vitamin B 12 | 2008 |
[Vitamin B12 deficiency in patients treated with metformin: an approach to adopt].
Topics: Humans; Hypoglycemic Agents; Metformin; Vitamin B 12 Deficiency | 2010 |
[Vitamin B12 deficiency secondary to metformin therapy].
Topics: Aged; Anemia; Diabetes Mellitus, Type 2; Drug Synergism; Female; Folic Acid; Humans; Hyperhomocystei | 2010 |
[Metformin and vitamin B12 deficiency].
Topics: Aged; Anemia; Female; Folic Acid; Humans; Hyperhomocysteinemia; Hypoglycemic Agents; Intestinal Abso | 2010 |
Metformin, B(12), and enhanced breast cancer response to chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Diabetes Mellitus; Female; Humans; | 2010 |
[An approach to adopt in patients with metformin-associated vitamin B12 deficiency].
Topics: Humans; Hypoglycemic Agents; Metformin; Vitamin B 12 Deficiency | 2010 |
Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy.
Topics: Aged; Humans; Hypoglycemic Agents; Male; Metformin; Peripheral Nervous System Diseases; Vitamin B 12 | 2010 |
Association between vitamin B12 levels and mortality in hospitalized older adults.
Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Drug-Related Side Effects and Adverse Reactions; F | 2010 |
Reduced serum vitamin B-12 in patients taking metformin.
Topics: Diabetes Mellitus, Type 2; Dietary Supplements; Humans; Hypoglycemic Agents; Metformin; Risk Factors | 2010 |
Diabetes drug interferes with vitamin B12.
Topics: Diabetes Mellitus, Type 2; Folic Acid; Health Knowledge, Attitudes, Practice; Humans; Hypoglycemic A | 2010 |
Clinical pearls in general internal medicine.
Topics: Abdominal Pain; Adrenergic alpha-1 Receptor Antagonists; Adult; Aged; Androgen Antagonists; Anti-Inf | 2011 |
[Mini-review BMJ "rational testing" Praxis 2011;100(2):99-103].
Topics: Adolescent; Adult; Age Factors; Aged; Child; Diet, Vegetarian; Fatigue; Female; Humans; Hypoglycemic | 2011 |
More adverse neurological consequences of metformin-induced vitamin B12 deficiency.
Topics: Humans; Hypoglycemic Agents; Male; Metformin; Peripheral Nervous System Diseases; Vitamin B 12 Defic | 2011 |
[Vitamin B12 deficiency in diabetic patients taking metformin].
Topics: Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; | 2012 |
Association of biochemical B₁₂ deficiency with metformin therapy and vitamin B₁₂ supplements: the National Health and Nutrition Examination Survey, 1999-2006.
Topics: Aged; Dietary Supplements; Female; Humans; Male; Metformin; Middle Aged; Vitamin B 12; Vitamin B 12 | 2012 |
Metformin associated B12 deficiency.
Topics: Diabetes Mellitus, Type 2; Humans; Hydroxocobalamin; Hypoglycemic Agents; Malabsorption Syndromes; M | 2012 |
Evaluation of vitamin B12 monitoring in a veteran population on long-term, high-dose metformin therapy.
Topics: Anemia; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Drug Monitoring; Humans; Hypoglycemic Agen | 2012 |
Vitamin B(12) deficiency associated with concomitant metformin and proton pump inhibitor use.
Topics: Aged; Female; Humans; Male; Metformin; Middle Aged; Proton Pump Inhibitors; Retrospective Studies; V | 2012 |
[Vitamin B(12) deficiency in type 2 diabetics treated with metformin].
Topics: Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; | 2013 |
Metformin-associated vitamin B12 deficiency.
Topics: Aged; Aged, 80 and over; Female; Homocysteine; Humans; Hypoglycemic Agents; Male; Metformin; Middle | 2002 |
[Does the vitamin B12 deficiency caused by metformin disappear again after stopping this drug?].
Topics: Calcium, Dietary; Diabetes Mellitus, Type 2; Dietary Supplements; Humans; Hypoglycemic Agents; Male; | 2002 |
Does metformin interfere with thiamine?
Topics: Drug Interactions; Humans; Hypoglycemic Agents; Metformin; Thiamine; Thiamine Deficiency; Vitamin B | 2003 |
A case of megaloblastic anemia due to vitamin B12 deficiency precipitated in a totally gastrectomized type II diabetic patient following the introduction of metformin therapy.
Topics: Aged; Anemia, Megaloblastic; Diabetes Mellitus, Type 2; Female; Gastrectomy; Humans; Hypoglycemic Ag | 2003 |
Mild cobalamin deficiency associated with long-term metformin intake--reply.
Topics: Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Metfo | 2004 |
Use of metformin is a cause of vitamin B12 deficiency.
Topics: Humans; Hypoglycemic Agents; Metformin; Vitamin B 12 Deficiency | 2004 |
Case 25-2004: a woman with severe obesity, diabetes, and hypertension.
Topics: Diabetes Mellitus, Type 1; Female; Gastric Bypass; Humans; Hypoglycemic Agents; Metformin; Obesity, | 2004 |
Metformin-related vitamin B12 deficiency.
Topics: Aged, 80 and over; Diabetes Mellitus, Type 2; Diarrhea; Female; Humans; Hypoglycemic Agents; Metform | 2006 |
[Diagnosis of vitamin B12 deficiency revised].
Topics: Humans; Hypoglycemic Agents; Metformin; Vitamin B 12; Vitamin B 12 Deficiency | 2006 |
[Factors influencing homocysteineamia in type 2 diabetic patients].
Topics: Diabetes Mellitus, Type 2; Female; Folic Acid; Glycated Hemoglobin; Homocysteine; Humans; Hyperhomoc | 2006 |
Risk factors of vitamin B(12) deficiency in patients receiving metformin.
Topics: Age Factors; Aged; Case-Control Studies; Databases as Topic; Diabetes Mellitus; Dose-Response Relati | 2006 |
[Metformin can cause vitamin B 12 deficiency in diabetes].
Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Risk Factors; Vitamin B 12 Defici | 2007 |
Metformin and vitamin B12 deficiency: the role of H2 receptor antagonists and proton pump inhibitors.
Topics: Aged; Aged, 80 and over; Diabetes Mellitus; Famotidine; Gastritis; Histamine H2 Antagonists; Humans; | 2007 |
[Metformin and vitamin B 12 deficiency].
Topics: Humans; Hypoglycemic Agents; Intestinal Absorption; Metformin; Vitamin B 12; Vitamin B 12 Deficiency | 2007 |
The long and short of metformin-related vitamin B12 deficiency.
Topics: Humans; Hypoglycemic Agents; Metformin; Time Factors; Vitamin B 12 Deficiency | 2007 |
Vitamin B12 deficiency in patients receiving metformin: clinical data.
Topics: Aged; Humans; Hypoglycemic Agents; Metformin; Time Factors; Vitamin B 12 Deficiency | 2007 |
Metformin and vitamin B12 deficiency: association and not causation may play a major role in cohort studies.
Topics: Cohort Studies; Humans; Hypoglycemic Agents; Metformin; Time Factors; Vitamin B 12 Deficiency | 2007 |
Drug-induced vitamin B12 deficiency.
Topics: Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Metformin; Vitamin B 12; Vitam | 2007 |
Hyperhomocysteinemia, deep vein thrombosis and vitamin B12 deficiency in a metformin-treated diabetic patient.
Topics: Aged; Diabetes Mellitus, Type 2; Female; Humans; Hyperhomocysteinemia; Hypoglycemic Agents; Metformi | 2007 |
[Megaloblastic anemia caused by malabsorption of vitamin B12 during long-term metformin therapy].
Topics: Aged; Anemia, Macrocytic; Anemia, Megaloblastic; Diabetes Mellitus; Female; Humans; Malabsorption Sy | 1983 |
Megaloblastic anaemia due to vitamin B12 malabsorption associated with long-term metformin treatment.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Diabetes Mellitus; Female; Humans; Intestinal Absorption; | 1980 |
Efficacy of metformin in non-insulin-dependent diabetes mellitus.
Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Vitamin B 12 Deficiency | 1996 |
Metformin and vitamin B12 deficiency.
Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Vitamin B 12 D | 2002 |
Metformin and B 12 malabsorption.
Topics: Humans; Intestinal Absorption; Metformin; Vitamin B 12 Deficiency | 1972 |
Metformin and B-12 malabsorption.
Topics: Biguanides; Intestinal Absorption; Metformin; Vitamin B 12 Deficiency | 1972 |
Vitamin B 12 and metformin.
Topics: Acidosis; Diabetes Mellitus; Folic Acid; Humans; Intestinal Absorption; Lactates; Metformin; Phenfor | 1971 |