metformin has been researched along with Ureteral Obstruction in 6 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Ureteral Obstruction: Blockage in any part of the URETER causing obstruction of urine flow from the kidney to the URINARY BLADDER. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as HYDRONEPHROSIS and obstructive nephropathy.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin is a well-known AMP-activated protein kinase (AMPK) activator, and it has been shown to inhibit organ fibrosis." | 7.85 | Metformin attenuates renal fibrosis in both AMPKα2-dependent and independent manners. ( Feng, Y; Wang, S; Xiao, H; Zhang, Y, 2017) |
| " In this study, we investigated its effects on renal fibrosis in a mouse model of unilateral ureteral obstruction (UUO) in vivo and in angiotensin II (Ang II)-treated renal fibroblast NRK-49F cells in vitro." | 7.83 | Metformin Prevents Renal Fibrosis in Mice with Unilateral Ureteral Obstruction and Inhibits Ang II-Induced ECM Production in Renal Fibroblasts. ( Gan, X; Lu, L; Miao, N; Shen, Y; Xu, D; Xu, J; Xue, H; Zhang, W; Zhou, L, 2016) |
| "Metformin treatment surprisingly resulted in a higher proportion of monocytes with infiltratory capacity 7 days after UUO." | 5.51 | Metformin modulates immune cell infiltration into the kidney during unilateral ureteral obstruction in mice. ( Christensen, M; Jensen, MS; Møller, BK; Nørgård, MØ; Nørregaard, R, 2019) |
| "Metformin is a well-known AMP-activated protein kinase (AMPK) activator, and it has been shown to inhibit organ fibrosis." | 3.85 | Metformin attenuates renal fibrosis in both AMPKα2-dependent and independent manners. ( Feng, Y; Wang, S; Xiao, H; Zhang, Y, 2017) |
| " In this study, we investigated its effects on renal fibrosis in a mouse model of unilateral ureteral obstruction (UUO) in vivo and in angiotensin II (Ang II)-treated renal fibroblast NRK-49F cells in vitro." | 3.83 | Metformin Prevents Renal Fibrosis in Mice with Unilateral Ureteral Obstruction and Inhibits Ang II-Induced ECM Production in Renal Fibroblasts. ( Gan, X; Lu, L; Miao, N; Shen, Y; Xu, D; Xu, J; Xue, H; Zhang, W; Zhou, L, 2016) |
| "Metformin was administered via drinking water to mice with a unilateral ureteric obstruction (UUO) model of renal fibrosis." | 1.91 | Mutation of regulatory phosphorylation sites in PFKFB2 does not affect the anti-fibrotic effect of metformin in the kidney. ( Gleich, K; Harley, G; Katerelos, M; Lee, M; Mount, PF; Power, DA, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Harley, G | 1 |
| Katerelos, M | 1 |
| Gleich, K | 1 |
| Lee, M | 1 |
| Mount, PF | 1 |
| Power, DA | 1 |
| Christensen, M | 1 |
| Nørgård, MØ | 1 |
| Jensen, MS | 1 |
| Møller, BK | 1 |
| Nørregaard, R | 1 |
| Cavaglieri, RC | 1 |
| Day, RT | 1 |
| Feliers, D | 1 |
| Abboud, HE | 1 |
| Shen, Y | 1 |
| Miao, N | 1 |
| Xu, J | 1 |
| Gan, X | 1 |
| Xu, D | 1 |
| Zhou, L | 1 |
| Xue, H | 1 |
| Zhang, W | 1 |
| Lu, L | 1 |
| Feng, Y | 1 |
| Wang, S | 1 |
| Zhang, Y | 1 |
| Xiao, H | 1 |
| Scannapieco, G | 1 |
| Franzoso, F | 1 |
| Grasso, M | 1 |
6 other studies available for metformin and Ureteral Obstruction
| Article | Year |
|---|---|
Mutation of regulatory phosphorylation sites in PFKFB2 does not affect the anti-fibrotic effect of metformin in the kidney.
Topics: Animals; Disease Models, Animal; Fibrosis; Kidney; Kidney Diseases; Metformin; Mice; Mutation; Phosp | 2023 |
Metformin modulates immune cell infiltration into the kidney during unilateral ureteral obstruction in mice.
Topics: Animals; B-Lymphocytes; Cell Movement; Kidney; Male; Metformin; Mice; Mice, Inbred C57BL; Monocytes; | 2019 |
Metformin prevents renal interstitial fibrosis in mice with unilateral ureteral obstruction.
Topics: Adenylate Kinase; Animals; Anti-Inflammatory Agents; Drug Evaluation, Preclinical; Fibrosis; Kidney | 2015 |
Metformin Prevents Renal Fibrosis in Mice with Unilateral Ureteral Obstruction and Inhibits Ang II-Induced ECM Production in Renal Fibroblasts.
Topics: Angiotensin II; Animals; Disease Models, Animal; Extracellular Matrix Proteins; Fibroblasts; Gene Ex | 2016 |
Metformin attenuates renal fibrosis in both AMPKα2-dependent and independent manners.
Topics: AMP-Activated Protein Kinases; Animals; Fibrosis; Gene Expression Regulation; Kidney; Metformin; Mic | 2017 |
[Severe hypoglycemia caused by sulfonylureas and biguanides in a patient with obstructive anuria: resolution with ureteral stent].
Topics: Aged; Anuria; Female; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Metformin; Remission Ind | 2002 |