metformin has been researched along with Tuberculosis, Pulmonary in 13 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Tuberculosis, Pulmonary: MYCOBACTERIUM infections of the lung.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Moreover, MET-associated lactic acidosis (MALA) needs to be considered and the incidence of MALA in patients with type 2 DM-TB coinfection remains unknown." | 9.27 | A case risk study of lactic acidosis risk by metformin use in type 2 diabetes mellitus tuberculosis coinfection patients. ( Mertaniasih, NM; Novita, BD; Pranoto, A; Soediono, EI, 2018) |
| " Metformin (MET) is a potent combination drug to elevate anti-TB efficacy and able to regulate inflammation." | 7.88 | Metformin associated inflammation levels regulation in type 2 diabetes mellitus-tuberculosis coinfection patients - A case report. ( Novita, BD; Nugraha, J; Soediono, EI, 2018) |
| "The addition of metformin to standard ATT did not hasten sputum culture conversion but diminished excess inflammation, thus reducing lung tissue damage as seen by faster clearance on X-ray and reduced inflammatory markers." | 5.51 | Randomized Trial of Metformin With Anti-Tuberculosis Drugs for Early Sputum Conversion in Adults With Pulmonary Tuberculosis. ( Devi, P; Gomathy, NS; Guleria, R; Jawahar, S; Kadam, A; Kumar, H; Mamulwar, M; Mane, A; Menon, J; Mohan, A; Padmapriydarsini, C; Pavankumar, N; Ramesh, PM; Reddy, D; Sekar, L; Shandil, RK; Shanmugam, P; Singh, M; Singh, UB; Suresh, C, 2022) |
| "Metformin treatment had no significant effect on sputum culture conversion (p = 0." | 5.48 | The effect of metformin on culture conversion in tuberculosis patients with diabetes mellitus. ( Chung, HS; Han, SK; Heo, EY; Kim, DK; Lee, JK; Lee, YJ; Park, JH, 2018) |
| " Moreover, MET-associated lactic acidosis (MALA) needs to be considered and the incidence of MALA in patients with type 2 DM-TB coinfection remains unknown." | 5.27 | A case risk study of lactic acidosis risk by metformin use in type 2 diabetes mellitus tuberculosis coinfection patients. ( Mertaniasih, NM; Novita, BD; Pranoto, A; Soediono, EI, 2018) |
| " Metformin (MET) is a potent combination drug to elevate anti-TB efficacy and able to regulate inflammation." | 3.88 | Metformin associated inflammation levels regulation in type 2 diabetes mellitus-tuberculosis coinfection patients - A case report. ( Novita, BD; Nugraha, J; Soediono, EI, 2018) |
| "Metformin treatment had no significant effect on sputum culture conversion (p = 0." | 1.48 | The effect of metformin on culture conversion in tuberculosis patients with diabetes mellitus. ( Chung, HS; Han, SK; Heo, EY; Kim, DK; Lee, JK; Lee, YJ; Park, JH, 2018) |
| "Metformin use was independently associated with a lower risk of incident TB (hazard ratio [HR]: 0." | 1.48 | Metformin use is associated with a low risk of tuberculosis among newly diagnosed diabetes mellitus patients with normal renal function: A nationwide cohort study with validated diagnostic criteria. ( Chang, CH; Chen, SM; Chiang, CY; Ho, CM; Lee, CH; Lee, MC; Wang, JY, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 10 (76.92) | 24.3611 |
| 2020's | 3 (23.08) | 2.80 |
| Authors | Studies |
|---|---|
| Padmapriydarsini, C | 1 |
| Mamulwar, M | 1 |
| Mohan, A | 1 |
| Shanmugam, P | 1 |
| Gomathy, NS | 1 |
| Mane, A | 1 |
| Singh, UB | 1 |
| Pavankumar, N | 1 |
| Kadam, A | 1 |
| Kumar, H | 2 |
| Suresh, C | 1 |
| Reddy, D | 1 |
| Devi, P | 1 |
| Ramesh, PM | 1 |
| Sekar, L | 1 |
| Jawahar, S | 1 |
| Shandil, RK | 1 |
| Singh, M | 2 |
| Menon, J | 1 |
| Guleria, R | 2 |
| Kumar, NP | 1 |
| Moideen, K | 1 |
| Nancy, A | 1 |
| Viswanathan, V | 1 |
| Shruthi, BS | 1 |
| Sivakumar, S | 1 |
| Hissar, S | 1 |
| Kornfeld, H | 1 |
| Babu, S | 1 |
| Frenkel, JDH | 1 |
| Ackart, DF | 1 |
| Todd, AK | 1 |
| DiLisio, JE | 1 |
| Hoffman, S | 1 |
| Tanner, S | 1 |
| Kiran, D | 1 |
| Murray, M | 1 |
| Chicco, A | 1 |
| Obregón-Henao, A | 1 |
| Podell, BK | 1 |
| Basaraba, RJ | 1 |
| Liu, Q | 1 |
| You, N | 1 |
| Pan, H | 1 |
| Shen, Y | 1 |
| Lu, P | 1 |
| Wang, J | 1 |
| Lu, W | 1 |
| Zhu, L | 1 |
| Martinez, L | 1 |
| Dutta, NK | 1 |
| Pinn, ML | 1 |
| Karakousis, PC | 1 |
| Lee, YJ | 1 |
| Han, SK | 1 |
| Park, JH | 1 |
| Lee, JK | 1 |
| Kim, DK | 1 |
| Chung, HS | 1 |
| Heo, EY | 1 |
| Ma, Y | 1 |
| Pang, Y | 1 |
| Shu, W | 1 |
| Liu, YH | 1 |
| Ge, QP | 1 |
| Du, J | 1 |
| Li, L | 1 |
| Gao, WW | 1 |
| Novita, BD | 3 |
| Pranoto, A | 1 |
| Soediono, EI | 2 |
| Mertaniasih, NM | 1 |
| Lee, MC | 1 |
| Chiang, CY | 1 |
| Lee, CH | 1 |
| Ho, CM | 1 |
| Chang, CH | 1 |
| Wang, JY | 1 |
| Chen, SM | 1 |
| Nugraha, J | 1 |
| Padmapriyadarsini, C | 1 |
| Bhavani, PK | 1 |
| Natrajan, M | 1 |
| Ponnuraja, C | 1 |
| Gomathy, SN | 1 |
| Jawahar, SM | 1 |
| Balganesh, T | 1 |
| Swaminathan, S | 1 |
| Huang, LK | 1 |
| Jiang, LD | 1 |
| Lai, YC | 1 |
| Wu, MH | 1 |
| Chang, SC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Metformin for Sputum Conversion in Patients With Active Pulmonary Tuberculosis: A Randomized Controlled Trial[NCT05215990] | Phase 1/Phase 2 | 80 participants (Anticipated) | Interventional | 2022-01-15 | Recruiting | ||
| A Prospective, Randomized Open-Label Phase II Study of the Safety and Tolerability of Metformin in Combination With Standard Antimicrobial Treatment of Pulmonary Tuberculosis in People With TB and Co-infected With HIV[NCT04930744] | Phase 2 | 112 participants (Anticipated) | Interventional | 2021-08-03 | Recruiting | ||
| Metformin as Adjunctive Therapy in Overweight and Obese Patients With Dengue: an Open-label Safety and Tolerability Trial[NCT04377451] | Phase 1/Phase 2 | 120 participants (Actual) | Interventional | 2020-07-27 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metformin and Tuberculosis, Pulmonary
| Article | Year |
|---|---|
Metformin: A review of its potential as enhancer for anti tuberculosis efficacy in diabetes mellitus-tuberculosis coinfection patients.
Topics: Antitubercular Agents; Coinfection; Diabetes Mellitus, Type 2; Drug Synergism; Drug Therapy, Combina | 2019 |
3 trials available for metformin and Tuberculosis, Pulmonary
9 other studies available for metformin and Tuberculosis, Pulmonary
| Article | Year |
|---|---|
Systemic RAGE ligands are upregulated in tuberculosis individuals with diabetes co-morbidity and modulated by anti-tuberculosis treatment and metformin therapy.
Topics: Adult; Aged; Antigens, Neoplasm; Antitubercular Agents; Case-Control Studies; Comorbidity; Diabetes | 2019 |
Metformin enhances protection in guinea pigs chronically infected with Mycobacterium tuberculosis.
Topics: Animals; Cytokines; Energy Metabolism; Glucose; Glucose Intolerance; Guinea Pigs; Hypoglycemic Agent | 2020 |
Glycemic Trajectories and Treatment Outcomes of Patients with Newly Diagnosed Tuberculosis: A Prospective Study in Eastern China.
Topics: Adult; Antitubercular Agents; Blood Glucose; China; Cohort Studies; Diabetes Mellitus; Female; Human | 2021 |
Metformin Adjunctive Therapy Does Not Improve the Sterilizing Activity of the First-Line Antitubercular Regimen in Mice.
Topics: Animals; Antitubercular Agents; Bacterial Load; Disease Models, Animal; Drug Synergism; Drug Therapy | 2017 |
The effect of metformin on culture conversion in tuberculosis patients with diabetes mellitus.
Topics: Adult; Aged; Antitubercular Agents; Diabetes Complications; Diabetes Mellitus; Female; Humans; Hypog | 2018 |
Metformin reduces the relapse rate of tuberculosis patients with diabetes mellitus: experiences from 3-year follow-up.
Topics: China; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Metformin; | 2018 |
Metformin use is associated with a low risk of tuberculosis among newly diagnosed diabetes mellitus patients with normal renal function: A nationwide cohort study with validated diagnostic criteria.
Topics: Adult; Biopsy; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Incidence; Longitudin | 2018 |
Metformin associated inflammation levels regulation in type 2 diabetes mellitus-tuberculosis coinfection patients - A case report.
Topics: Adult; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Inflammation; Interleukin-10; | 2018 |
Pulmonary tuberculous cavities in diabetic patients: Glycemic control is still the dominant factor despite the emerging role of metformin.
Topics: Aged; Aged, 80 and over; Blood Glucose; Diabetes Mellitus; Female; Glycated Hemoglobin; Humans; Logi | 2019 |