metformin has been researched along with Thyroid Nodule in 7 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Thyroid Nodule: A small circumscribed mass in the THYROID GLAND that can be of neoplastic growth or non-neoplastic abnormality. It lacks a well-defined capsule or glandular architecture. Thyroid nodules are often benign but can be malignant. The growth of nodules can lead to a multinodular goiter (GOITER, NODULAR).
| Excerpt | Relevance | Reference |
|---|---|---|
| "In subjects with insulin resistance, metformin therapy significantly decreased thyroid volume and nodule size." | 9.22 | Metformin Decreases Thyroid Volume and Nodule Size in Subjects with Insulin Resistance: A Preliminary Study. ( Anil, C; Atesagaoglu, B; Bascil Tutuncu, N; Gursoy, A; Kut, A; Nar, A, 2016) |
| "Metformin induces reductions in thyroid nodule size and TSH and HOMA-IR levels in patients with thyroid nodules and insulin resistance." | 9.01 | Role of Metformin in the Treatment of Patients with Thyroid Nodules and Insulin Resistance: A Systematic Review and Meta-Analysis. ( He, X; Hu, C; Liu, C; Liu, Y; Tang, W; Wu, D; Xu, B; Xu, T, 2019) |
| "In subjects with insulin resistance, metformin therapy significantly decreased thyroid volume and nodule size." | 5.22 | Metformin Decreases Thyroid Volume and Nodule Size in Subjects with Insulin Resistance: A Preliminary Study. ( Anil, C; Atesagaoglu, B; Bascil Tutuncu, N; Gursoy, A; Kut, A; Nar, A, 2016) |
| "Metformin induces reductions in thyroid nodule size and TSH and HOMA-IR levels in patients with thyroid nodules and insulin resistance." | 5.01 | Role of Metformin in the Treatment of Patients with Thyroid Nodules and Insulin Resistance: A Systematic Review and Meta-Analysis. ( He, X; Hu, C; Liu, C; Liu, Y; Tang, W; Wu, D; Xu, B; Xu, T, 2019) |
| "Metabolic syndrome has been associated with nodular goiter." | 1.42 | Association between worse metabolic control and increased thyroid volume and nodular disease in elderly adults with metabolic syndrome. ( Barreto, A; Blanc, E; Brenta, G; Brodschi, D; Cejas, C; Faingold, C; Fossati, P; Musso, C; Nepote, A; Ponce, C; Salgado, P; Schnitman, M, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Cannarella, R | 1 |
| Condorelli, RA | 1 |
| Barbagallo, F | 1 |
| Aversa, A | 1 |
| Calogero, AE | 1 |
| La Vignera, S | 1 |
| He, X | 1 |
| Wu, D | 1 |
| Hu, C | 1 |
| Xu, T | 1 |
| Liu, Y | 1 |
| Liu, C | 1 |
| Xu, B | 1 |
| Tang, W | 1 |
| Schlechte, JA | 1 |
| Blanc, E | 1 |
| Ponce, C | 1 |
| Brodschi, D | 1 |
| Nepote, A | 1 |
| Barreto, A | 1 |
| Schnitman, M | 1 |
| Fossati, P | 1 |
| Salgado, P | 1 |
| Cejas, C | 1 |
| Faingold, C | 1 |
| Musso, C | 1 |
| Brenta, G | 1 |
| Anil, C | 1 |
| Kut, A | 1 |
| Atesagaoglu, B | 1 |
| Nar, A | 1 |
| Bascil Tutuncu, N | 1 |
| Gursoy, A | 1 |
| Cintosun, U | 1 |
| Naharci, MI | 1 |
| Doruk, H | 1 |
| Rezzónico, J | 1 |
| Rezzónico, M | 1 |
| Pusiol, E | 1 |
| Pitoia, F | 1 |
| Niepomniszcze, H | 1 |
1 review available for metformin and Thyroid Nodule
| Article | Year |
|---|---|
Role of Metformin in the Treatment of Patients with Thyroid Nodules and Insulin Resistance: A Systematic Review and Meta-Analysis.
Topics: Blood Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Obesity; Overwei | 2019 |
2 trials available for metformin and Thyroid Nodule
| Article | Year |
|---|---|
Metformin Decreases Thyroid Volume and Nodule Size in Subjects with Insulin Resistance: A Preliminary Study.
Topics: Adult; Aged; Body Mass Index; Body Weights and Measures; Diet; Exercise; Humans; Hypoglycemic Agents | 2016 |
Metformin treatment for small benign thyroid nodules in patients with insulin resistance.
Topics: Adult; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combinati | 2011 |
4 other studies available for metformin and Thyroid Nodule
| Article | Year |
|---|---|
TSH lowering effects of metformin: a possible mechanism of action.
Topics: Diabetes Mellitus, Type 2; Follow-Up Studies; Humans; Hypoglycemic Agents; Insulin Receptor Substrat | 2021 |
Update in endocrinology: evidence published in 2012.
Topics: Biliopancreatic Diversion; Bone Density; Bone Density Conservation Agents; Bone Diseases, Metabolic; | 2013 |
Association between worse metabolic control and increased thyroid volume and nodular disease in elderly adults with metabolic syndrome.
Topics: Aged; Aged, 80 and over; Anthropometry; Argentina; Body Mass Index; Cohort Studies; Cross-Sectional | 2015 |
Comment on "Metformin Decreases Thyroid Volume and Nodule Size in Subjects with Insulin Resistance: A Preliminary Study".
Topics: Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Thyroid Gland; Thyroid Nodule; | 2017 |