metformin has been researched along with Tauopathies in 5 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Tauopathies: Neurodegenerative disorders involving deposition of abnormal tau protein isoforms (TAU PROTEINS) in neurons and glial cells in the brain. Pathological aggregations of tau proteins are associated with mutation of the tau gene on chromosome 17 in patients with ALZHEIMER DISEASE; DEMENTIA; PARKINSONIAN DISORDERS; progressive supranuclear palsy (SUPRANUCLEAR PALSY, PROGRESSIVE); and corticobasal degeneration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin-treated mice revealed increased expression of lipogenic genes, i." | 1.51 | Metformin Therapy Aggravates Neurodegenerative Processes in ApoE-/- Mice. ( Brichmann, E; Kuhla, A; Meuth, L; Rühlmann, C; Thiele, R; Vollmar, B, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Elnahas, EM | 1 |
| Abuelezz, SA | 1 |
| Mohamad, MI | 1 |
| Nabil, MM | 1 |
| Abdelraouf, SM | 1 |
| Bahaa, N | 1 |
| Hassan, GAM | 1 |
| Aboul-Fotouh, S | 1 |
| Dehghan, E | 1 |
| Zhang, Y | 1 |
| Saremi, B | 1 |
| Yadavali, S | 1 |
| Hakimi, A | 1 |
| Dehghani, M | 1 |
| Goodarzi, M | 1 |
| Tu, X | 1 |
| Robertson, S | 1 |
| Lin, R | 1 |
| Chudhuri, A | 1 |
| Mirzaei, H | 1 |
| Chen, JL | 1 |
| Luo, C | 1 |
| Pu, D | 1 |
| Zhang, GQ | 1 |
| Zhao, YX | 1 |
| Sun, Y | 1 |
| Zhao, KX | 1 |
| Liao, ZY | 1 |
| Lv, AK | 1 |
| Zhu, SY | 1 |
| Zhou, J | 1 |
| Xiao, Q | 1 |
| Kuhla, A | 1 |
| Brichmann, E | 1 |
| Rühlmann, C | 1 |
| Thiele, R | 1 |
| Meuth, L | 1 |
| Vollmar, B | 1 |
| Barini, E | 1 |
| Antico, O | 1 |
| Zhao, Y | 1 |
| Asta, F | 1 |
| Tucci, V | 1 |
| Catelani, T | 1 |
| Marotta, R | 1 |
| Xu, H | 1 |
| Gasparini, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-center, Prospective, Cohort Study to Elucidate the Effects of Metformin Treatment on Steroid Hormones and Social Behavior. Linking Autistic Behaviorial Symptoms to Changes in Steroid Hormone Availability[NCT04930471] | 45 participants (Anticipated) | Observational | 2021-06-30 | Not yet recruiting | |||
| "Randomized, Double-blind, Placebo-controlled Study to Assess the Effect of Metformin, an Activator of AMPK, on Cognitive Measures of Progression in Huntington's Disease Patients"[NCT04826692] | Phase 3 | 60 participants (Anticipated) | Interventional | 2021-12-10 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for metformin and Tauopathies
| Article | Year |
|---|---|
Novel role of peroxisome proliferator activated receptor-α in valproic acid rat model of autism: Mechanistic study of risperidone and metformin monotherapy versus combination.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Fema | 2022 |
Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway.
Topics: Animals; Antihypertensive Agents; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Line | 2017 |
Metformin attenuates diabetes-induced tau hyperphosphorylation in vitro and in vivo by enhancing autophagic clearance.
Topics: Animals; Autophagy; Cell Line; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Hy | 2019 |
Metformin Therapy Aggravates Neurodegenerative Processes in ApoE-/- Mice.
Topics: Adenylate Kinase; Animals; Apolipoproteins E; Cognitive Dysfunction; Disease Models, Animal; Fibrobl | 2019 |
Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Metformin; Mice; Mice, Transgenic; tau Pro | 2016 |