metformin has been researched along with Syndrome in 24 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Syndrome: A characteristic symptom complex.
| Excerpt | Relevance | Reference |
|---|---|---|
| "to explore the possibility of metformin protective effect on frailty syndrome." | 7.80 | Relationship between metformin and frailty syndrome in elderly people with type 2 diabetes. ( Dewiasty, E; Purnamasari, D; Setiati, S; Sumantri, S, 2014) |
| "A 2-hour oral glucose tolerance test (OGTT) and a rapid intravenous glucose tolerance test (IVGTT) were performed before treatment was initiated, after treatment with metformin and at the end of 1 year of combination therapy with metformin and rosiglitazone to calculate quantitative insulin sensitivity check index (QUICKI) and acute insulin response (AIR)." | 7.74 | Effect of metformin and rosiglitazone in a prepubertal boy with Alström syndrome. ( Anhalt, H; Bhangoo, A; Collin, GB; Maclaren, N; Marshall, JD; Naggert, JK; Sinha, SK; Ten, S, 2007) |
| "Metformin is a medication likely to improve measures of cardiometabolic disturbance in young people with mental illness." | 7.30 | Double-blind, randomised placebo-controlled clinical trial of metformin as an adjunct to a sleep-wake, activity and metabolically focused behavioural intervention to improve cardiometabolic outcomes and mood symptoms in youth with major mood syndromes: st ( Carpenter, JS; Crouse, J; Hamilton, B; Hickie, IB; Hockey, S; Koethe, D; McHugh, C; Nichles, A; Scott, EM; Song, YJC; Wilson, C; Zmicerevska, N, 2023) |
| "To date, interventions for frailty have primarily focused on exercise and/or nutritional interventions, many of which show improvement in frailty-related characteristics, such as gait speed and lower extremity strength and function." | 6.61 | Review of Interventions for the Frailty Syndrome and the Role of Metformin as a Potential Pharmacologic Agent for Frailty Prevention. ( Espinoza, SE; Jiwani, R; Wang, CP; Wang, J, 2019) |
| "A 70-year-old man with type 2 diabetes presented to our department with poor glycemic control without evidence of hypoglycemia, but the levels of serum insulin and IAA were very high." | 6.53 | Gliclazide-Induced Insulin Autoimmune Syndrome: A Rare Case Report and Review on Literature. ( Cao, X; Feng, X; Hu, Y; Jiang, L; Li, Q; Liu, C; Luo, Y; Ma, J; Wang, Y; Yan, R; Yang, F; Yuan, L; Zhao, E; Zhu, Y, 2016) |
| "Metformin is an oral antidiabetic agent frequently used to manage type II diabetes." | 5.35 | [Constitutional syndrome associated to metformin induced hepatotoxicity]. ( Angueira Lapeña, T; Arranz de la Mata, G; Boixeda de Miquel, D; de la Poza Gómez, G; Rivero Fernández, M; Vázquez Romero, M, 2008) |
| "to explore the possibility of metformin protective effect on frailty syndrome." | 3.80 | Relationship between metformin and frailty syndrome in elderly people with type 2 diabetes. ( Dewiasty, E; Purnamasari, D; Setiati, S; Sumantri, S, 2014) |
| "A 2-hour oral glucose tolerance test (OGTT) and a rapid intravenous glucose tolerance test (IVGTT) were performed before treatment was initiated, after treatment with metformin and at the end of 1 year of combination therapy with metformin and rosiglitazone to calculate quantitative insulin sensitivity check index (QUICKI) and acute insulin response (AIR)." | 3.74 | Effect of metformin and rosiglitazone in a prepubertal boy with Alström syndrome. ( Anhalt, H; Bhangoo, A; Collin, GB; Maclaren, N; Marshall, JD; Naggert, JK; Sinha, SK; Ten, S, 2007) |
| "Metformin is a medication likely to improve measures of cardiometabolic disturbance in young people with mental illness." | 3.30 | Double-blind, randomised placebo-controlled clinical trial of metformin as an adjunct to a sleep-wake, activity and metabolically focused behavioural intervention to improve cardiometabolic outcomes and mood symptoms in youth with major mood syndromes: st ( Carpenter, JS; Crouse, J; Hamilton, B; Hickie, IB; Hockey, S; Koethe, D; McHugh, C; Nichles, A; Scott, EM; Song, YJC; Wilson, C; Zmicerevska, N, 2023) |
| "To date, interventions for frailty have primarily focused on exercise and/or nutritional interventions, many of which show improvement in frailty-related characteristics, such as gait speed and lower extremity strength and function." | 2.61 | Review of Interventions for the Frailty Syndrome and the Role of Metformin as a Potential Pharmacologic Agent for Frailty Prevention. ( Espinoza, SE; Jiwani, R; Wang, CP; Wang, J, 2019) |
| "A 70-year-old man with type 2 diabetes presented to our department with poor glycemic control without evidence of hypoglycemia, but the levels of serum insulin and IAA were very high." | 2.53 | Gliclazide-Induced Insulin Autoimmune Syndrome: A Rare Case Report and Review on Literature. ( Cao, X; Feng, X; Hu, Y; Jiang, L; Li, Q; Liu, C; Luo, Y; Ma, J; Wang, Y; Yan, R; Yang, F; Yuan, L; Zhao, E; Zhu, Y, 2016) |
| "Women with severe insulin resistance are a unique subset of polycystic ovary syndrome." | 2.41 | Induction of ovulation in infertile women with hyperandrogenism and insulin resistance. ( Barbieri, RL, 2000) |
| "Lactic acidosis was present in 2 patients at presentation and serum lactate was elevated in 7/15 patients tested." | 1.72 | The extrapyramidal syndromes of chronic kidney disease and dialysis (EPS-CKDD): diagnostic criteria, risk factors and prognosis. ( Agarwal, A; Chemmanam, T; Irish, AB; Manickavasagar, R; Prentice, DA; Youssef, A, 2022) |
| "Metformin is an oral antidiabetic agent frequently used to manage type II diabetes." | 1.35 | [Constitutional syndrome associated to metformin induced hepatotoxicity]. ( Angueira Lapeña, T; Arranz de la Mata, G; Boixeda de Miquel, D; de la Poza Gómez, G; Rivero Fernández, M; Vázquez Romero, M, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (25.00) | 18.2507 |
| 2000's | 9 (37.50) | 29.6817 |
| 2010's | 4 (16.67) | 24.3611 |
| 2020's | 5 (20.83) | 2.80 |
| Authors | Studies |
|---|---|
| Wilson, C | 1 |
| Carpenter, JS | 1 |
| Nichles, A | 1 |
| Zmicerevska, N | 1 |
| Song, YJC | 1 |
| McHugh, C | 1 |
| Hamilton, B | 1 |
| Hockey, S | 1 |
| Crouse, J | 1 |
| Koethe, D | 1 |
| Scott, EM | 1 |
| Hickie, IB | 1 |
| Zaongo, SD | 1 |
| Chen, Y | 1 |
| Majore, S | 1 |
| Agolini, E | 1 |
| Micale, L | 1 |
| Pascolini, G | 1 |
| Zuppi, P | 1 |
| Cocciadiferro, D | 1 |
| Morlino, S | 1 |
| Mattiuzzo, M | 1 |
| Valiante, M | 1 |
| Castori, M | 1 |
| Novelli, A | 1 |
| Grammatico, P | 1 |
| Manickavasagar, R | 1 |
| Chemmanam, T | 1 |
| Youssef, A | 1 |
| Agarwal, A | 1 |
| Prentice, DA | 1 |
| Irish, AB | 1 |
| Aung, TKK | 1 |
| Chuah, TY | 1 |
| Chua, MWJ | 1 |
| Espinoza, SE | 1 |
| Jiwani, R | 1 |
| Wang, J | 1 |
| Wang, CP | 1 |
| Sumantri, S | 1 |
| Setiati, S | 1 |
| Purnamasari, D | 1 |
| Dewiasty, E | 1 |
| Enkhtuvshin, B | 1 |
| Nagashima, S | 1 |
| Saito, N | 1 |
| Wakabayashi, T | 1 |
| Ando, A | 1 |
| Takahashi, M | 1 |
| Sakai, K | 1 |
| Yamamuro, D | 1 |
| Nagasaka, S | 1 |
| Tamemoto, H | 1 |
| Ishibashi, S | 1 |
| Feng, X | 1 |
| Yuan, L | 1 |
| Hu, Y | 1 |
| Zhu, Y | 1 |
| Yang, F | 1 |
| Jiang, L | 1 |
| Yan, R | 1 |
| Luo, Y | 1 |
| Zhao, E | 1 |
| Liu, C | 1 |
| Wang, Y | 1 |
| Li, Q | 2 |
| Cao, X | 1 |
| Ma, J | 1 |
| de la Poza Gómez, G | 1 |
| Rivero Fernández, M | 1 |
| Vázquez Romero, M | 1 |
| Angueira Lapeña, T | 1 |
| Arranz de la Mata, G | 1 |
| Boixeda de Miquel, D | 1 |
| Ibrahim, TM | 1 |
| Sinha, SK | 1 |
| Bhangoo, A | 1 |
| Anhalt, H | 1 |
| Maclaren, N | 1 |
| Marshall, JD | 1 |
| Collin, GB | 1 |
| Naggert, JK | 1 |
| Ten, S | 1 |
| Atabek, ME | 1 |
| Pernet, A | 1 |
| Verge, CF | 1 |
| Donaghue, KC | 1 |
| Williams, PF | 1 |
| Cowell, CT | 1 |
| Silink, M | 1 |
| Grant, PJ | 1 |
| Minchoff, LE | 1 |
| Grandin, JA | 1 |
| Rique, S | 1 |
| Ibáñez, L | 1 |
| Marcos, MV | 1 |
| Carrascosa, A | 1 |
| Potau, N | 1 |
| Barbieri, RL | 1 |
| Marcus, AO | 1 |
| Kotler, DP | 1 |
| Lee, F | 1 |
| Patel, HR | 1 |
| Copland, P | 1 |
| Kahn, L | 1 |
| Isnard, F | 1 |
| André, P | 1 |
| Lamey, PJ | 1 |
| Gibson, J | 1 |
| Barclay, SC | 1 |
| Miller, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Superoxide Dismutase (SOD) Enzyme on Frailty and Health Related Quality of Life Among Indonesian Pre-frail Elderly: A Double Blind Randomized Controlled Trial[NCT02753582] | Phase 4 | 150 participants (Anticipated) | Interventional | 2016-04-30 | Recruiting | ||
| Randomized-Controlled Trial of Metformin to Prevent Frailty in Pre-frail Elderly[NCT02325245] | Phase 3 | 150 participants (Anticipated) | Interventional | 2015-03-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for metformin and Syndrome
| Article | Year |
|---|---|
Metformin may be a viable adjunctive therapeutic option to potentially enhance immune reconstitution in HIV-positive immunological non-responders.
Topics: Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Dysbiosis; | 2023 |
Review of Interventions for the Frailty Syndrome and the Role of Metformin as a Potential Pharmacologic Agent for Frailty Prevention.
Topics: Animals; Diabetes Mellitus, Type 2; Exercise; Frailty; Humans; Hypoglycemic Agents; Metformin; Syndr | 2019 |
Gliclazide-Induced Insulin Autoimmune Syndrome: A Rare Case Report and Review on Literature.
Topics: Acarbose; Aged; Autoimmune Diseases; Diabetes Mellitus, Type 2; Drug Substitution; Gliclazide; Human | 2016 |
[Therapeutic approach to a multi-metabolic syndrome].
Topics: Acarbose; Combined Modality Therapy; Diet Therapy; Enzyme Inhibitors; Exercise; Glucose Intolerance; | 1995 |
The effects of metformin on cardiovascular risk factors.
Topics: Animals; Diabetes Mellitus, Type 2; Fibrinolysis; Glucose; Humans; Hyperlipidemias; Hypertension; Hy | 1995 |
Syndrome X. Recognition and management of this metabolic disorder in primary care.
Topics: Arteriosclerosis; Diabetes Mellitus, Type 2; Humans; Hypertension; Metabolic Diseases; Metformin; Ob | 1996 |
Induction of ovulation in infertile women with hyperandrogenism and insulin resistance.
Topics: Acanthosis Nigricans; Female; Humans; Hyperandrogenism; Hypoglycemic Agents; Infertility, Female; In | 2000 |
Safety of drugs commonly used to treat hypertension, dyslipidemia, and Type 2 diabetes (the metabolic syndrome): part 2.
Topics: Acarbose; Cardiovascular Diseases; Chromans; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Human | 2000 |
[Identification and prevention of vascular risk. Significance of metformin].
Topics: Anthropometry; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Humans; I | 1990 |
1 trial available for metformin and Syndrome
| Article | Year |
|---|---|
Double-blind, randomised placebo-controlled clinical trial of metformin as an adjunct to a sleep-wake, activity and metabolically focused behavioural intervention to improve cardiometabolic outcomes and mood symptoms in youth with major mood syndromes: st
Topics: Adolescent; Australia; Cardiovascular Diseases; Humans; Metformin; Randomized Controlled Trials as T | 2023 |
14 other studies available for metformin and Syndrome
| Article | Year |
|---|---|
Clinical presentation and molecular characterization of a novel patient with variant POC1A-related syndrome.
Topics: Acanthosis Nigricans; Adult; Age of Onset; Cell Cycle Proteins; Computer Simulation; Congenital Hype | 2021 |
The extrapyramidal syndromes of chronic kidney disease and dialysis (EPS-CKDD): diagnostic criteria, risk factors and prognosis.
Topics: Acidosis, Lactic; Basal Ganglia Diseases; Child, Preschool; Diabetes Mellitus, Type 2; Female; Human | 2022 |
More Than Meets the Eye: A Patient with Hand Swelling and Newly Diagnosed Diabetes Mellitus.
Topics: Aged; Amlodipine; Anemia; Antihypertensive Agents; Blood Sedimentation; C-Reactive Protein; Diabetes | 2021 |
Relationship between metformin and frailty syndrome in elderly people with type 2 diabetes.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Frail Elderly; Ger | 2014 |
Relationship between metformin and frailty syndrome in elderly people with type 2 diabetes.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Frail Elderly; Ger | 2014 |
Relationship between metformin and frailty syndrome in elderly people with type 2 diabetes.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Frail Elderly; Ger | 2014 |
Relationship between metformin and frailty syndrome in elderly people with type 2 diabetes.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Frail Elderly; Ger | 2014 |
Successful pregnancy outcomes in a patient with type A insulin resistance syndrome.
Topics: Adult; Antigens, CD; Female; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin Resistance; Metform | 2015 |
[Constitutional syndrome associated to metformin induced hepatotoxicity].
Topics: Aged, 80 and over; Chemical and Drug Induced Liver Injury; Humans; Hypoglycemic Agents; Male; Metfor | 2008 |
Hyperglycaemic hyperosmolar syndrome in young obese Afro-Caribbean adults--a diagnostic dilemma. Report of two cases.
Topics: Adolescent; Adult; Black People; Diagnosis, Differential; Female; Humans; Hyperglycemic Hyperosmolar | 2003 |
Effect of metformin and rosiglitazone in a prepubertal boy with Alström syndrome.
Topics: Abnormalities, Multiple; Child; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fatty Liver; H | 2007 |
Re: "Effect of metformin and rosiglitazone in a prepubertal boy with Alström syndrome", Sinha SK et al., JPEM 2007; 20: 1045-1052.
Topics: Child; Deafness; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 2008 |
Insulin-resistant diabetes during growth hormone therapy in a child with SHORT syndrome.
Topics: Abnormalities, Multiple; Anodontia; Blood Glucose; Child; Diabetes Mellitus, Lipoatrophic; Eye Abnor | 1994 |
Effects of metformin on androgens and insulin concentrations in type A insulin resistance syndrome.
Topics: Acanthosis Nigricans; Adolescent; Androgens; Female; Humans; Hyperandrogenism; Hyperinsulinism; Hypo | 2000 |
Metabolic alterations in HIV lipodystrophy. IAPAC sessions 2001, July 18-19, 2001 - Chicago.
Topics: Acidosis; Anti-HIV Agents; Bone Diseases, Metabolic; Cost-Benefit Analysis; Glucose; Glucose Intoler | 2001 |
Fowler's syndrome: cause or consequence of insulin resistance?
Topics: Adult; Electromyography; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Polycys | 2002 |
Grinspan's syndrome: a drug-induced phenomenon?
Topics: Aged; Aged, 80 and over; Atenolol; Bendroflumethiazide; Chlorpropamide; Diabetes Mellitus, Type 2; D | 1990 |