metformin has been researched along with Stomach Ulcer in 5 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin (500 mg/kg) was given orally for 3 days prior to indomethacin or ethanol challenge." | 5.72 | The Effect of Metformin on Ethanol- and IndomethacinInduced Gastric Ulcers in Rats. ( Alican, İ; Aydın, B; Cabadak, H; Cumbul, A; Ercan, F; İpek, BE; Yüksel, M, 2022) |
| "Omeprazole and metformin were found to decrease stomach acidity and ulcer index, restored the histological features and increased mucin levels." | 5.62 | The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway. ( AbdelAziz, EY; Menze, ET; Tadros, MG, 2021) |
| "Of all drugs used in the treatment of Type 2 diabetes, the insulin sensitizers thiazolidinediones (e." | 5.36 | Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats. ( Abdel-Gaber, SA; Ashour, OM; Fouad, AA; Morsy, MA, 2010) |
| " Six weeks following streptozotocin or saline injection, gastric ulcers were induced by serosal application of acetic acid." | 3.77 | Role of activation of 5'-adenosine monophosphate-activated protein kinase in gastric ulcer healing in diabetic rats. ( Baraka, AM; Deif, MM, 2011) |
| "Metformin (500 mg/kg) was given orally for 3 days prior to indomethacin or ethanol challenge." | 1.72 | The Effect of Metformin on Ethanol- and IndomethacinInduced Gastric Ulcers in Rats. ( Alican, İ; Aydın, B; Cabadak, H; Cumbul, A; Ercan, F; İpek, BE; Yüksel, M, 2022) |
| "Omeprazole and metformin were found to decrease stomach acidity and ulcer index, restored the histological features and increased mucin levels." | 1.62 | The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway. ( AbdelAziz, EY; Menze, ET; Tadros, MG, 2021) |
| "Of all drugs used in the treatment of Type 2 diabetes, the insulin sensitizers thiazolidinediones (e." | 1.36 | Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats. ( Abdel-Gaber, SA; Ashour, OM; Fouad, AA; Morsy, MA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| İpek, BE | 1 |
| Yüksel, M | 1 |
| Cumbul, A | 1 |
| Ercan, F | 1 |
| Cabadak, H | 1 |
| Aydın, B | 1 |
| Alican, İ | 1 |
| AbdelAziz, EY | 1 |
| Tadros, MG | 1 |
| Menze, ET | 1 |
| Morsy, MA | 1 |
| Ashour, OM | 1 |
| Fouad, AA | 1 |
| Abdel-Gaber, SA | 1 |
| Baraka, AM | 1 |
| Deif, MM | 1 |
| Gyr, N | 1 |
| Berger, W | 1 |
| Fridrich, R | 1 |
| Denes, A | 1 |
| Stalder, GA | 1 |
1 trial available for metformin and Stomach Ulcer
| Article | Year |
|---|---|
[Effect of dimethylbiguanide on stomach emptying and on oral glucose tolerance].
Topics: Blood Glucose; Colloids; Digestion; Dumping Syndrome; Gastrectomy; Glucose Tolerance Test; Humans; I | 1971 |
4 other studies available for metformin and Stomach Ulcer
| Article | Year |
|---|---|
The Effect of Metformin on Ethanol- and IndomethacinInduced Gastric Ulcers in Rats.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; DNA Nucleotidylexotransferase; Ethanol; Gastric Mucosa; In | 2022 |
The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Gastric Mucosa; Indomethacin; Male; Metformin; N | 2021 |
Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats.
Topics: Animals; Catalase; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dinoprostone; Gastric | 2010 |
Role of activation of 5'-adenosine monophosphate-activated protein kinase in gastric ulcer healing in diabetic rats.
Topics: Acetic Acid; Animals; Blood Glucose; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Experi | 2011 |