metformin has been researched along with Spinal Cord Injuries in 17 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We found a possible mechanism that metformin could reduce inflammation and apoptosis, and promote functional recovery of SCI rats through activating Wnt/β-catenin signaling pathway." | 7.96 | Therapeutic effect of metformin on inflammation and apoptosis after spinal cord injury in rats through the Wnt/β-catenin signaling pathway. ( Gao, K; Li, K; Lv, C; Wang, F; Zhang, T, 2020) |
| "We found a possible mechanism that metformin could reduce inflammation and apoptosis, and promote functional recovery of SCI rats through activating Wnt/β-catenin signaling pathway." | 3.96 | Therapeutic effect of metformin on inflammation and apoptosis after spinal cord injury in rats through the Wnt/β-catenin signaling pathway. ( Gao, K; Li, K; Lv, C; Wang, F; Zhang, T, 2020) |
| "Metformin could be considered as an alternative therapeutic agent for SCI, as it potentially attenuates neuroinflammation, sensory and locomotor complications of cord injury." | 3.88 | Anti-inflammatory effects of Metformin improve the neuropathic pain and locomotor activity in spinal cord injured rats: introduction of an alternative therapy. ( Afshari, K; Dehdashtian, A; Dehpour, AR; Ebrahimi, MA; Faghir-Ghanesefat, H; Haddadi, NS; Haj-Mirzaian, A; Iranmehr, A; Javidan, AN; Mohammadi, F; Rahimi, N; Tavangar, SM, 2018) |
| "Metformin has been proven in clinical and animal experiments to repair damaged structures and functions by promoting endogenous neurogenesis." | 1.91 | Robust and Multifunctional Nanoparticles Assembled from Natural Polyphenols and Metformin for Efficient Spinal Cord Regeneration. ( Gu, Z; Li, Y; Liu, P; Wang, T; Xu, J; Yuan, T; Zhang, J, 2023) |
| " The short half-life and low bioavailability of many drugs also limit the use of many drugs in SCI." | 1.91 | Encapsulation of Selenium Nanoparticles and Metformin in Macrophage-Derived Cell Membranes for the Treatment of Spinal Cord Injury. ( An, J; Du, J; Hu, Y; Li, Y; Liu, X; Mei, X; Sun, J; Tian, H; Wu, C; Xiong, Y; Yu, Y, 2023) |
| "Metformin (Met) is a glucose-lowering drug that shows a good effect for the treatment of SCI." | 1.72 | Glutathione-modified macrophage-derived cell membranes encapsulated metformin nanogels for the treatment of spinal cord injury. ( Jiang, X; Liu, X; Mei, X; Shen, W; Tian, H; Wu, C; Yu, Q, 2022) |
| "Metformin (MET) has anti-oxidant, anti-inflammatory, anti-apoptotic and neuroprotective properties, which may exert a potential therapeutic effect on SCI." | 1.72 | CAQK modification enhances the targeted accumulation of metformin-loaded nanoparticles in rats with spinal cord injury. ( Du, X; Jing, P; Li, T; Lin, Y; Liu, Z; Wan, Y; Wei, J; Yang, L; Zhong, Z; Zhou, M, 2022) |
| "Metformin is a widely used oral anti-diabetic agent for type 2 diabetes in the world." | 1.48 | Metformin Protects Against Spinal Cord Injury by Regulating Autophagy via the mTOR Signaling Pathway. ( Gao, Z; Guo, Y; He, X; Li, H; Li, Y; Liang, H; Wang, F, 2018) |
| "But, metformin treatment attenuated the accumulation of p62 and ubiquitinated proteins, suggesting a stimulative effect of autophagy flux by metformin." | 1.46 | Metformin Improves Functional Recovery After Spinal Cord Injury via Autophagy Flux Stimulation. ( Huang, YX; Lin, Y; Mao, C; Shen, LY; Tian, NF; Wang, Q; Wang, XY; Wu, Y; Wu, YS; Xu, HZ; Xuan, J; Zhang, D; Zhang, XL; Zheng, BB; Zhou, YF; Zhou, YL, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 11 (64.71) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, YQ | 1 |
| Xiong, J | 1 |
| He, ZL | 1 |
| Yuan, Y | 3 |
| Wang, BN | 1 |
| Xu, JY | 1 |
| Wu, M | 1 |
| Zhang, SS | 1 |
| Cai, SF | 1 |
| Zhao, JX | 1 |
| Xu, K | 2 |
| Zhang, HY | 1 |
| Xiao, J | 2 |
| Han, Q | 1 |
| Zheng, T | 1 |
| Zhang, L | 1 |
| Wu, N | 1 |
| Liang, J | 1 |
| Wu, H | 1 |
| Li, G | 1 |
| Chen, Q | 1 |
| Xie, D | 1 |
| Yao, Q | 1 |
| Yang, L | 2 |
| Yu, Q | 1 |
| Jiang, X | 1 |
| Liu, X | 2 |
| Shen, W | 1 |
| Mei, X | 3 |
| Tian, H | 2 |
| Wu, C | 2 |
| Li, T | 1 |
| Jing, P | 1 |
| Wan, Y | 1 |
| Du, X | 1 |
| Wei, J | 1 |
| Zhou, M | 1 |
| Liu, Z | 1 |
| Lin, Y | 2 |
| Zhong, Z | 1 |
| Fan, X | 1 |
| Guo, Z | 1 |
| Zhou, Z | 2 |
| Gao, W | 1 |
| Huang, Z | 2 |
| Lin, J | 1 |
| Jiang, H | 1 |
| Lin, W | 1 |
| Chen, J | 1 |
| Xiao, W | 1 |
| Lin, Q | 1 |
| Wang, J | 1 |
| Wen, S | 1 |
| Zhu, Q | 1 |
| Liu, J | 1 |
| Yuan, T | 1 |
| Wang, T | 1 |
| Zhang, J | 1 |
| Liu, P | 1 |
| Xu, J | 2 |
| Gu, Z | 1 |
| Li, Y | 4 |
| Sun, J | 1 |
| Du, J | 1 |
| An, J | 1 |
| Hu, Y | 1 |
| Xiong, Y | 1 |
| Yu, Y | 1 |
| Wang, H | 1 |
| Zheng, Z | 1 |
| Han, W | 1 |
| Zhou, K | 1 |
| Wang, Q | 2 |
| Xie, L | 1 |
| Zhang, H | 1 |
| Xu, H | 2 |
| Wu, Y | 4 |
| Zhang, T | 1 |
| Wang, F | 2 |
| Li, K | 1 |
| Lv, C | 2 |
| Gao, K | 2 |
| Zhang, D | 2 |
| Tang, Q | 1 |
| Zheng, G | 1 |
| Wang, C | 2 |
| Zhou, Y | 1 |
| Xuan, J | 2 |
| Tian, N | 1 |
| Wang, X | 1 |
| Zhang, X | 1 |
| Oda, SS | 1 |
| Guo, Y | 2 |
| Li, H | 1 |
| Liang, H | 1 |
| Gao, Z | 1 |
| He, X | 1 |
| Afshari, K | 1 |
| Dehdashtian, A | 1 |
| Haddadi, NS | 1 |
| Haj-Mirzaian, A | 1 |
| Iranmehr, A | 1 |
| Ebrahimi, MA | 1 |
| Tavangar, SM | 1 |
| Faghir-Ghanesefat, H | 1 |
| Mohammadi, F | 1 |
| Rahimi, N | 1 |
| Javidan, AN | 1 |
| Dehpour, AR | 1 |
| Zheng, BB | 1 |
| Zhou, YL | 1 |
| Wu, YS | 1 |
| Zhou, YF | 1 |
| Huang, YX | 1 |
| Shen, LY | 1 |
| Mao, C | 1 |
| Wang, XY | 1 |
| Tian, NF | 1 |
| Xu, HZ | 1 |
| Zhang, XL | 1 |
| Liu, C | 1 |
| Zhao, H | 1 |
| Shen, Z | 1 |
| Li, Z | 1 |
| Yao, T | 1 |
1 review available for metformin and Spinal Cord Injuries
| Article | Year |
|---|---|
Effect of Metformin on Locomotor Function Recovery in Rat Spinal Cord Injury Model: A Meta-analysis.
Topics: Animals; Disease Models, Animal; Hypoglycemic Agents; Locomotion; Metformin; Rats; Recovery of Funct | 2021 |
16 other studies available for metformin and Spinal Cord Injuries
| Article | Year |
|---|---|
Metformin promotes microglial cells to facilitate myelin debris clearance and accelerate nerve repairment after spinal cord injury.
Topics: Animals; Axons; Metformin; Microglia; Myelin Sheath; Nerve Regeneration; Rats; Rats, Sprague-Dawley; | 2022 |
Metformin loaded injectable silk fibroin microsphere for the treatment of spinal cord injury.
Topics: Axons; Fibroins; Humans; Metformin; Microspheres; Nerve Regeneration; Silk; Spinal Cord Injuries; Ti | 2022 |
Glutathione-modified macrophage-derived cell membranes encapsulated metformin nanogels for the treatment of spinal cord injury.
Topics: Animals; Cell Membrane; Glutathione; Inflammation; Macrophages; Metformin; Nanogels; Rats; Rats, Spr | 2022 |
CAQK modification enhances the targeted accumulation of metformin-loaded nanoparticles in rats with spinal cord injury.
Topics: Animals; Metformin; Nanoparticles; Neurons; Rats; Spinal Cord; Spinal Cord Injuries; Tissue Distribu | 2022 |
Metformin Protects against Spinal Cord Injury and Cell Pyroptosis via AMPK/NLRP3 Inflammasome Pathway.
Topics: AMP-Activated Protein Kinases; Animals; Inflammasomes; Metformin; NLR Family, Pyrin Domain-Containin | 2022 |
Metformin promotes Schwann cell remyelination, preserves neural tissue and improves functional recovery after spinal cord injury.
Topics: Humans; Metformin; Oligodendroglia; Recovery of Function; Remyelination; Schwann Cells; Spinal Cord; | 2023 |
Robust and Multifunctional Nanoparticles Assembled from Natural Polyphenols and Metformin for Efficient Spinal Cord Regeneration.
Topics: Animals; Metformin; Multifunctional Nanoparticles; Polyphenols; Rats; Spinal Cord Injuries; Spinal C | 2023 |
Encapsulation of Selenium Nanoparticles and Metformin in Macrophage-Derived Cell Membranes for the Treatment of Spinal Cord Injury.
Topics: Animals; Antioxidants; Cell Membrane; Macrophages; Metformin; Mice; Nanoparticles; Reactive Oxygen S | 2023 |
Metformin Promotes Axon Regeneration after Spinal Cord Injury through Inhibiting Oxidative Stress and Stabilizing Microtubule.
Topics: Animals; Axons; Chromones; Metformin; Microtubules; Mitochondria; Morpholines; NF-E2-Related Factor | 2020 |
Therapeutic effect of metformin on inflammation and apoptosis after spinal cord injury in rats through the Wnt/β-catenin signaling pathway.
Topics: Animals; Apoptosis; Inflammation; Male; Metformin; Neuroprotective Agents; Rats, Sprague-Dawley; Spi | 2020 |
Metformin ameliorates BSCB disruption by inhibiting neutrophil infiltration and MMP-9 expression but not direct TJ proteins expression regulation.
Topics: AMP-Activated Protein Kinases; Animals; Blood-Nerve Barrier; Cell Movement; Female; Gene Expression | 2017 |
Metformin Protects against Experimental Acrylamide Neuropathy in Rats.
Topics: Acrylamide; Administration, Oral; Animals; Brain Injuries; Caspase 3; Disease Models, Animal; Gene E | 2017 |
Metformin Protects Against Spinal Cord Injury by Regulating Autophagy via the mTOR Signaling Pathway.
Topics: Animals; Autophagy; Cell Death; Female; Metformin; Neurons; Neuroprotective Agents; Rats, Sprague-Da | 2018 |
Anti-inflammatory effects of Metformin improve the neuropathic pain and locomotor activity in spinal cord injured rats: introduction of an alternative therapy.
Topics: Animals; Central Nervous System Agents; Disease Models, Animal; Hyperalgesia; Inflammation; Locomoti | 2018 |
Metformin Improves Functional Recovery After Spinal Cord Injury via Autophagy Flux Stimulation.
Topics: Adenylate Kinase; Animals; Apoptosis; Autophagosomes; Autophagy; Enzyme Activation; Female; Lysosome | 2017 |
Metformin preconditioning provide neuroprotection through enhancement of autophagy and suppression of inflammation and apoptosis after spinal cord injury.
Topics: Animals; Apoptosis; Autophagy; Female; Inflammation; Metformin; Neurons; Neuroprotective Agents; NF- | 2016 |