metformin has been researched along with Skin Aging in 7 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Skin Aging: The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin has shown multiple effects beyond its widely known antidiabetic effect." | 7.01 | Τhe Endless Beauty of Metformin: Does It Also Protect from Skin Aging? A Narrative Review. ( Gouveri, E; Papanas, N, 2023) |
| "Skin aging is aggravated by the fact that the skin is in direct contact with extrinsic factors, such as ultraviolet irradiation." | 2.66 | Shedding Light on the Effects of Calorie Restriction and its Mimetics on Skin Biology. ( Choi, YJ, 2020) |
| "0." | 1.62 | Possible treatment for UVB-induced skin injury: Anti-inflammatory and cytoprotective role of metformin in UVB-irradiated keratinocytes. ( Chen, X; Chen, Y; Gu, H; Li, M; Lin, S; Song, C; Xiao, T; Xu, S, 2021) |
| "Metformin has been successfully used as an anti-aging agent but exact molecular mechanisms of metformin in anti-aging remain unknown." | 1.62 | Metformin reverses the effects of high glucose on human dermal fibroblasts of aged skin via downregulating RELA/p65 expression. ( Cınar, S; Sarac, EY; Sayitoglu, M; Solakoglu, S; Soydas, T; Sultuybek, GK; Tiryaki, T, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 6 (85.71) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Q | 1 |
| Zhang, H | 1 |
| Yang, Y | 1 |
| Zhang, S | 1 |
| Wang, J | 1 |
| Zhang, D | 1 |
| Yu, H | 1 |
| Mostafa, DK | 1 |
| Nayel, OA | 1 |
| Abdulmalek, S | 1 |
| Abdelbary, AA | 1 |
| Ismail, CA | 1 |
| Gouveri, E | 1 |
| Papanas, N | 1 |
| Choi, YJ | 1 |
| Xiao, T | 1 |
| Chen, Y | 1 |
| Song, C | 1 |
| Xu, S | 1 |
| Lin, S | 1 |
| Li, M | 1 |
| Chen, X | 1 |
| Gu, H | 1 |
| Soydas, T | 1 |
| Sayitoglu, M | 1 |
| Sarac, EY | 1 |
| Cınar, S | 1 |
| Solakoglu, S | 1 |
| Tiryaki, T | 1 |
| Sultuybek, GK | 1 |
| Zhao, P | 1 |
| Sui, BD | 1 |
| Liu, N | 1 |
| Lv, YJ | 1 |
| Zheng, CX | 1 |
| Lu, YB | 1 |
| Huang, WT | 1 |
| Zhou, CH | 1 |
| Chen, J | 1 |
| Pang, DL | 1 |
| Fei, DD | 1 |
| Xuan, K | 1 |
| Hu, CH | 1 |
| Jin, Y | 1 |
2 reviews available for metformin and Skin Aging
| Article | Year |
|---|---|
Τhe Endless Beauty of Metformin: Does It Also Protect from Skin Aging? A Narrative Review.
Topics: Humans; Hypoglycemic Agents; Metformin; NF-kappa B; Skin; Skin Aging | 2023 |
Shedding Light on the Effects of Calorie Restriction and its Mimetics on Skin Biology.
Topics: Animals; Caloric Restriction; Dermatologic Agents; Fasting; Humans; Inflammation; Metformin; Peroxis | 2020 |
5 other studies available for metformin and Skin Aging
| Article | Year |
|---|---|
Metformin Attenuates UVA-Induced Skin Photoaging by Suppressing Mitophagy and the PI3K/AKT/mTOR Pathway.
Topics: Animals; Fibroblasts; Metformin; Mice; Mitophagy; Phosphatidylinositol 3-Kinases; Proto-Oncogene Pro | 2022 |
Modulation of autophagy, apoptosis and oxidative stress: a clue for repurposing metformin in photoaging.
Topics: Animals; Antioxidants; Apoptosis; Autophagy; Cathepsin D; Female; Metformin; Mice; Oxidative Stress; | 2022 |
Possible treatment for UVB-induced skin injury: Anti-inflammatory and cytoprotective role of metformin in UVB-irradiated keratinocytes.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Carcinogenesis; Disease Models, Animal | 2021 |
Metformin reverses the effects of high glucose on human dermal fibroblasts of aged skin via downregulating RELA/p65 expression.
Topics: Apoptosis; Cells, Cultured; Down-Regulation; Female; Fibroblasts; Glucose; Humans; Metformin; Middle | 2021 |
Anti-aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application.
Topics: Acetyl-CoA Carboxylase; Administration, Cutaneous; Aging; AMP-Activated Protein Kinases; Animals; Cy | 2017 |