Page last updated: 2024-10-30

metformin and Skin Aging

metformin has been researched along with Skin Aging in 7 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Skin Aging: The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.

Research Excerpts

ExcerptRelevanceReference
"Metformin has shown multiple effects beyond its widely known antidiabetic effect."7.01Τhe Endless Beauty of Metformin: Does It Also Protect from Skin Aging? A Narrative Review. ( Gouveri, E; Papanas, N, 2023)
"Skin aging is aggravated by the fact that the skin is in direct contact with extrinsic factors, such as ultraviolet irradiation."2.66Shedding Light on the Effects of Calorie Restriction and its Mimetics on Skin Biology. ( Choi, YJ, 2020)
"0."1.62Possible treatment for UVB-induced skin injury: Anti-inflammatory and cytoprotective role of metformin in UVB-irradiated keratinocytes. ( Chen, X; Chen, Y; Gu, H; Li, M; Lin, S; Song, C; Xiao, T; Xu, S, 2021)
"Metformin has been successfully used as an anti-aging agent but exact molecular mechanisms of metformin in anti-aging remain unknown."1.62Metformin reverses the effects of high glucose on human dermal fibroblasts of aged skin via downregulating RELA/p65 expression. ( Cınar, S; Sarac, EY; Sayitoglu, M; Solakoglu, S; Soydas, T; Sultuybek, GK; Tiryaki, T, 2021)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (14.29)24.3611
2020's6 (85.71)2.80

Authors

AuthorsStudies
Chen, Q1
Zhang, H1
Yang, Y1
Zhang, S1
Wang, J1
Zhang, D1
Yu, H1
Mostafa, DK1
Nayel, OA1
Abdulmalek, S1
Abdelbary, AA1
Ismail, CA1
Gouveri, E1
Papanas, N1
Choi, YJ1
Xiao, T1
Chen, Y1
Song, C1
Xu, S1
Lin, S1
Li, M1
Chen, X1
Gu, H1
Soydas, T1
Sayitoglu, M1
Sarac, EY1
Cınar, S1
Solakoglu, S1
Tiryaki, T1
Sultuybek, GK1
Zhao, P1
Sui, BD1
Liu, N1
Lv, YJ1
Zheng, CX1
Lu, YB1
Huang, WT1
Zhou, CH1
Chen, J1
Pang, DL1
Fei, DD1
Xuan, K1
Hu, CH1
Jin, Y1

Reviews

2 reviews available for metformin and Skin Aging

ArticleYear
Τhe Endless Beauty of Metformin: Does It Also Protect from Skin Aging? A Narrative Review.
    Advances in therapy, 2023, Volume: 40, Issue:4

    Topics: Humans; Hypoglycemic Agents; Metformin; NF-kappa B; Skin; Skin Aging

2023
Shedding Light on the Effects of Calorie Restriction and its Mimetics on Skin Biology.
    Nutrients, 2020, May-24, Volume: 12, Issue:5

    Topics: Animals; Caloric Restriction; Dermatologic Agents; Fasting; Humans; Inflammation; Metformin; Peroxis

2020

Other Studies

5 other studies available for metformin and Skin Aging

ArticleYear
Metformin Attenuates UVA-Induced Skin Photoaging by Suppressing Mitophagy and the PI3K/AKT/mTOR Pathway.
    International journal of molecular sciences, 2022, Jun-23, Volume: 23, Issue:13

    Topics: Animals; Fibroblasts; Metformin; Mice; Mitophagy; Phosphatidylinositol 3-Kinases; Proto-Oncogene Pro

2022
Modulation of autophagy, apoptosis and oxidative stress: a clue for repurposing metformin in photoaging.
    Inflammopharmacology, 2022, Volume: 30, Issue:6

    Topics: Animals; Antioxidants; Apoptosis; Autophagy; Cathepsin D; Female; Metformin; Mice; Oxidative Stress;

2022
Possible treatment for UVB-induced skin injury: Anti-inflammatory and cytoprotective role of metformin in UVB-irradiated keratinocytes.
    Journal of dermatological science, 2021, Volume: 102, Issue:1

    Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Carcinogenesis; Disease Models, Animal

2021
Metformin reverses the effects of high glucose on human dermal fibroblasts of aged skin via downregulating RELA/p65 expression.
    Journal of physiology and biochemistry, 2021, Volume: 77, Issue:3

    Topics: Apoptosis; Cells, Cultured; Down-Regulation; Female; Fibroblasts; Glucose; Humans; Metformin; Middle

2021
Anti-aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application.
    Aging cell, 2017, Volume: 16, Issue:5

    Topics: Acetyl-CoA Carboxylase; Administration, Cutaneous; Aging; AMP-Activated Protein Kinases; Animals; Cy

2017