metformin has been researched along with Retinal Diseases in 8 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Retinal Diseases: Diseases involving the RETINA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Adolescents with type 1 diabetes have early macrovascular changes (increased intima-media thickness [IMT]) and early retinal changes that predict clinical disease in adulthood." | 2.87 | Early atherosclerosis is associated with retinal microvascular changes in adolescents with type 1 diabetes. ( Anderson, J; Couper, JJ; Gent, R; Giles, LC; Liew, G; Peña, AS; Wong, TY, 2018) |
| " In vivo, metformin treatment significantly increased the number of surviving RGCs, the b/NR wave amplitude and the thickness of the inner retina but had no obvious adverse effects on the fundus." | 1.72 | Regulation of mitophagy by metformin improves the structure and function of retinal ganglion cells following excitotoxicity-induced retinal injury. ( Hu, FY; Liu, HL; Wu, JH; Xu, P, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 5 (62.50) | 2.80 |
| Authors | Studies |
|---|---|
| Amin, SV | 1 |
| Khanna, S | 1 |
| Parvar, SP | 1 |
| Shaw, LT | 1 |
| Dao, D | 1 |
| Hariprasad, SM | 1 |
| Skondra, D | 1 |
| Liu, HL | 1 |
| Hu, FY | 1 |
| Xu, P | 1 |
| Wu, JH | 1 |
| Sekar, P | 1 |
| Hsiao, G | 1 |
| Hsu, SH | 1 |
| Huang, DY | 1 |
| Lin, WW | 1 |
| Chan, CM | 1 |
| Shu, CW | 1 |
| Tsen, CL | 1 |
| Li, MS | 1 |
| Bee, YS | 1 |
| Lin, SH | 1 |
| Sheu, SJ | 1 |
| Watanabe, K | 1 |
| Asano, D | 1 |
| Ushikubo, H | 1 |
| Morita, A | 1 |
| Mori, A | 1 |
| Sakamoto, K | 1 |
| Ishii, K | 1 |
| Nakahara, T | 1 |
| Rowan, S | 1 |
| Taylor, A | 1 |
| Peña, AS | 1 |
| Liew, G | 1 |
| Anderson, J | 1 |
| Giles, LC | 1 |
| Gent, R | 1 |
| Wong, TY | 1 |
| Couper, JJ | 1 |
| Stalenhoef, AF | 1 |
| van Lith-Verhoeven, JJ | 1 |
2 reviews available for metformin and Retinal Diseases
| Article | Year |
|---|---|
Metformin and retinal diseases in preclinical and clinical studies: Insights and review of literature.
Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Glaucoma, Open-Angle; Macular Degeneration | 2022 |
The Role of Microbiota in Retinal Disease.
Topics: Animals; Conjunctiva; Cornea; Diabetic Retinopathy; Disease Models, Animal; Gastrointestinal Microbi | 2018 |
1 trial available for metformin and Retinal Diseases
| Article | Year |
|---|---|
Early atherosclerosis is associated with retinal microvascular changes in adolescents with type 1 diabetes.
Topics: Adolescent; Age of Onset; Atherosclerosis; Child; Cross-Sectional Studies; Diabetes Mellitus, Type 1 | 2018 |
5 other studies available for metformin and Retinal Diseases
| Article | Year |
|---|---|
Regulation of mitophagy by metformin improves the structure and function of retinal ganglion cells following excitotoxicity-induced retinal injury.
Topics: Animals; Apoptosis; Eye Injuries; Lactate Dehydrogenases; Metformin; Mitophagy; N-Methylaspartate; R | 2022 |
Metformin inhibits methylglyoxal-induced retinal pigment epithelial cell death and retinopathy via AMPK-dependent mechanisms: Reversing mitochondrial dysfunction and upregulating glyoxalase 1.
Topics: AMP-Activated Protein Kinases; Animals; Epithelial Cells; Glycation End Products, Advanced; Lactoylg | 2023 |
Metformin and rapamycin protect cells from vital dye-induced damage in retinal pigment epithelial cells and in vivo.
Topics: Adult; Animals; Apoptosis; Cell Survival; Cells, Cultured; Coloring Agents; Disease Models, Animal; | 2020 |
Metformin Protects against NMDA-Induced Retinal Injury through the MEK/ERK Signaling Pathway in Rats.
Topics: Animals; Excitatory Amino Acid Agonists; Extracellular Signal-Regulated MAP Kinases; Gene Expression | 2021 |
Blurred vision.
Topics: Adult; Diabetes Mellitus, Type 2; Humans; Hyperglycemia; Insulin; Male; Metformin; Retinal Diseases; | 2007 |