metformin has been researched along with Retinal Detachment in 1 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Retinal Detachment: Separation of the inner layers of the retina (neural retina) from the pigment epithelium. Retinal detachment occurs more commonly in men than in women, in eyes with degenerative myopia, in aging and in aphakia. It may occur after an uncomplicated cataract extraction, but it is seen more often if vitreous humor has been lost during surgery. (Dorland, 27th ed; Newell, Ophthalmology: Principles and Concepts, 7th ed, p310-12).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Insulin and the insulin sensitizers rosiglitazone and metformin prevent in part the RD-induced cone loss in vivo, despite the persistence of inflammation CONCLUSION: Our results describe a new mechanism by which inflammation induces cone death in RD, likely through cone starvation due to the downregulation of RdCVF that could be reversed by insulin." | 3.96 | Insulin inhibits inflammation-induced cone death in retinal detachment. ( Augustin, S; Beguier, F; Berrod, JP; Blot, G; Charles-Messance, H; Conart, JB; Delarasse, C; Guillonneau, X; Léveillard, T; Millet-Puel, G; Roubeix, C; Sahel, JA; Sennlaub, F; Touhami, S, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Conart, JB | 1 |
| Blot, G | 1 |
| Augustin, S | 1 |
| Millet-Puel, G | 1 |
| Roubeix, C | 1 |
| Beguier, F | 1 |
| Charles-Messance, H | 1 |
| Touhami, S | 1 |
| Sahel, JA | 1 |
| Berrod, JP | 1 |
| Léveillard, T | 1 |
| Guillonneau, X | 1 |
| Delarasse, C | 1 |
| Sennlaub, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intravitreous CytokinE Level in pAtient With retiNal Detachment[NCT03318588] | 74 participants (Actual) | Observational | 2017-11-15 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 other study available for metformin and Retinal Detachment
| Article | Year |
|---|---|
Insulin inhibits inflammation-induced cone death in retinal detachment.
Topics: Adult; Animals; Cell Death; Eye Proteins; Female; Glucose; Humans; Hypoglycemic Agents; Inflammation | 2020 |