metformin has been researched along with Retinal Degeneration in 4 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Retinal Degeneration: A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin was found to have a neuroprotective effect on the retina in ENU induced rat model of RP." | 5.72 | Can metformin modulate the retinal degenerative changes in a rat model of retinitis pigmentosa? ( Ahmed, AA; Eltony, SA; Mohaseb, HS; Sayed, MM, 2022) |
| "Metformin was found to have a neuroprotective effect on the retina in ENU induced rat model of RP." | 1.72 | Can metformin modulate the retinal degenerative changes in a rat model of retinitis pigmentosa? ( Ahmed, AA; Eltony, SA; Mohaseb, HS; Sayed, MM, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eltony, SA | 1 |
| Mohaseb, HS | 1 |
| Ahmed, AA | 1 |
| Sayed, MM | 1 |
| Brown, EE | 1 |
| Lewin, AS | 1 |
| Ash, JD | 2 |
| Xu, L | 1 |
| Kong, L | 1 |
| Wang, J | 1 |
| Athanasiou, D | 1 |
| Aguila, M | 1 |
| Opefi, CA | 1 |
| South, K | 1 |
| Bellingham, J | 1 |
| Bevilacqua, D | 1 |
| Munro, PM | 1 |
| Kanuga, N | 1 |
| Mackenzie, FE | 1 |
| Dubis, AM | 1 |
| Georgiadis, A | 1 |
| Graca, AB | 1 |
| Pearson, RA | 1 |
| Ali, RR | 1 |
| Sakami, S | 1 |
| Palczewski, K | 1 |
| Sherman, MY | 1 |
| Reeves, PJ | 1 |
| Cheetham, ME | 1 |
4 other studies available for metformin and Retinal Degeneration
| Article | Year |
|---|---|
Can metformin modulate the retinal degenerative changes in a rat model of retinitis pigmentosa?
Topics: Animals; Caspase 3; Disease Models, Animal; Humans; Male; Metformin; Rats; Rats, Wistar; Retina; Ret | 2022 |
AMPK May Play an Important Role in the Retinal Metabolic Ecosystem.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; DNA Damage; DNA, Mitochondrial; Gene | 2019 |
Stimulation of AMPK prevents degeneration of photoreceptors and the retinal pigment epithelium.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Female; Hypoglycemic Agents; Male; M | 2018 |
Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Humans; Metformin; Mice; Mutant Prot | 2017 |