metformin has been researched along with Reperfusion Injury in 47 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin (Met) has a protective effect against cardiac ischemia and reperfusion (I/R) injury." | 8.31 | Metformin ameliorates ferroptosis in cardiac ischemia and reperfusion by reducing NOX4 expression via promoting AMPKα. ( Bai, Y; Chang, C; Guo, Z; Jiao, Y; Qi, Y; Wu, Z, 2023) |
| "To assess the preventive role of metformin on rat ovarian ischemia reperfusion injury." | 8.02 | Metformin reduces ovarian ischemia reperfusion injury in rats by improving oxidative/nitrosative stress. ( Bozdag, Z; Bozdayi, MA; Demir, M; Ince, O; Kalyoncu, S; Taysi, S; Tuncer, M; Ulusal, H; Yilmaz, B, 2021) |
| "Metformin may act renoprotective prior to kidney transplantation by reducing ischemia-reperfusion injury (IRI)." | 8.02 | Metformin Preconditioning and Postconditioning to Reduce Ischemia Reperfusion Injury in an Isolated Ex Vivo Rat and Porcine Kidney Normothermic Machine Perfusion Model. ( de Vries, NJ; Huijink, TM; Leuvenink, HGD; Nijsten, MW; Ottens, PJ; Posma, RA; Touw, DJ; Venema, LH; Westerkamp, AC, 2021) |
| "To examine the effect of metformin treatment during ischemia/reperfusion injury in fatty liver and determine the possible mechanisms." | 7.96 | Metformin Attenuates Ischemia-reperfusion Injury of Fatty Liver in Rats Through Inhibition of the TLR4/NF-κB Axis ( Huang, C; Li, X; Wang, L; Yang, X, 2020) |
| "The aim of this study was to investigate the protective effect of metformin on the rat ovary against ischemia-reperfusion injury." | 7.88 | What is the protective effect of metformin on rat ovary against ischemia-reperfusion injury? ( Aydin, G; Ceylan Isik, A; Dayangan Sayan, C; Devrim, T; Karaca, G; Sema Ozkan, Z; Tulmac, OB; Yeral, I, 2018) |
| "The purpose of this study is to assess the potential effects of metformin on the development of EMT and tubulointerstitial fibrosis 12 weeks after acute renal ischemia-reperfusion." | 7.83 | Metformin alleviated EMT and fibrosis after renal ischemia-reperfusion injury in rats. ( Chen, Z; Guo, J; Jiang, G; Liu, X; Wang, M; Weng, X, 2016) |
| "Metformin was administered to rats orally by gavage 500 mg/kg once daily for one week before induction of cerebral ischemia (rats were subjected to 30 min of ischemia before decapitation) and ischemia/reperfusion (rats were subjected to 30 min of ischemia then 60 minutes of reperfusion before decapitation)." | 7.80 | Modulation of the oxidative stress by metformin in the cerebrum of rats exposed to global cerebral ischemia and ischemia/reperfusion. ( Abd-Elsameea, AA; Mohamed, AM; Moustaf, AA, 2014) |
| "Here, we have investigated the effect of metformin pretreatment in the rat models of global cerebral ischemia." | 7.80 | Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: interference of AMPK/PGC-1α pathway. ( Ashabi, G; Goudarzvand, M; Khalaj, L; Khodagholi, F; Nasiri, M, 2014) |
| "Metformin is a biguanide drug that exerts strong effects on multiple diseases." | 5.91 | Metformin protects against retinal ischemia/reperfusion injury through AMPK-mediated mitochondrial fusion. ( Han, XJ; Jiang, LP; Qu, XH; Sun, GF; Tou, FF; Wang, T; Xiao, JX; Zhang, K, 2023) |
| "Metformin (MET) has been the subject of many classic studies in possessing antiapoptotic, anti-inflammatory, antioxidation activities and antiviral." | 5.72 | Metformin protects against pericyte apoptosis and promotes neurogenesis through suppressing JNK p38 MAPK signalling activation in ischemia/reperfusion injury. ( Cui, K; Fu, X; Liu, C; Lu, Z; Man, J; Wang, J; Zhang, D; Zhang, Z, 2022) |
| "Metformin (Met) is a commonly used drug in the treatment of type 2 diabetes." | 5.62 | Neuroprotective effects of metformin on cerebral ischemia-reperfusion injury by regulating PI3K/Akt pathway. ( Gao, J; Guo, H; Li, X; Liu, Z; Lv, H; Ruan, C; Wang, Y; Yan, J, 2021) |
| "Metformin has anti-oxidative properties and protects against I/R injury." | 5.56 | Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway. ( Cui, R; Feng, Y; Jia, Y; Li, Z; Liu, C; Qu, K; Tong, Y; Wang, C; Zhang, J, 2020) |
| "Rats underwent cerebral ischemia/reperfusion and MET was administered orally at doses of 100 and 200 mg/kg for 56 days." | 5.56 | Long-term metformin therapy improves neurobehavioral functions and antioxidative activity after cerebral ischemia/reperfusion injury in rats. ( Allahtavakoli, M; Esmaeil-Moghaddam, S; Fatemi, I; Hakimizadeh, E; Kaeidi, A; Pak-Hashemi, M; Saeed-Askari, P, 2020) |
| "Metformin has a protective effect against I/R injury on the testis." | 5.43 | Protective effect of metformin on testicular ischemia/reperfusion injury in rats. ( Akbari, G; Asghari, A; Meghdadi, A; Mortazavi, P, 2016) |
| " The only drug that proved to be effective in reducing cardiovascular events is metformin, which increases AMP-activated protein kinase activity and has a potent cardioprotective effect against ischemia-reperfusion injury." | 4.86 | [Hypoglycemic therapy in heart disease patients with type 2 diabetes mellitus]. ( Cosmi, D; Cosmi, F, 2010) |
| "Metformin (Met) has a protective effect against cardiac ischemia and reperfusion (I/R) injury." | 4.31 | Metformin ameliorates ferroptosis in cardiac ischemia and reperfusion by reducing NOX4 expression via promoting AMPKα. ( Bai, Y; Chang, C; Guo, Z; Jiao, Y; Qi, Y; Wu, Z, 2023) |
| "Metformin may act renoprotective prior to kidney transplantation by reducing ischemia-reperfusion injury (IRI)." | 4.02 | Metformin Preconditioning and Postconditioning to Reduce Ischemia Reperfusion Injury in an Isolated Ex Vivo Rat and Porcine Kidney Normothermic Machine Perfusion Model. ( de Vries, NJ; Huijink, TM; Leuvenink, HGD; Nijsten, MW; Ottens, PJ; Posma, RA; Touw, DJ; Venema, LH; Westerkamp, AC, 2021) |
| "To assess the preventive role of metformin on rat ovarian ischemia reperfusion injury." | 4.02 | Metformin reduces ovarian ischemia reperfusion injury in rats by improving oxidative/nitrosative stress. ( Bozdag, Z; Bozdayi, MA; Demir, M; Ince, O; Kalyoncu, S; Taysi, S; Tuncer, M; Ulusal, H; Yilmaz, B, 2021) |
| "To examine the effect of metformin treatment during ischemia/reperfusion injury in fatty liver and determine the possible mechanisms." | 3.96 | Metformin Attenuates Ischemia-reperfusion Injury of Fatty Liver in Rats Through Inhibition of the TLR4/NF-κB Axis ( Huang, C; Li, X; Wang, L; Yang, X, 2020) |
| "The aim of this study was to investigate the protective effect of metformin on the rat ovary against ischemia-reperfusion injury." | 3.88 | What is the protective effect of metformin on rat ovary against ischemia-reperfusion injury? ( Aydin, G; Ceylan Isik, A; Dayangan Sayan, C; Devrim, T; Karaca, G; Sema Ozkan, Z; Tulmac, OB; Yeral, I, 2018) |
| "The purpose of this study is to assess the potential effects of metformin on the development of EMT and tubulointerstitial fibrosis 12 weeks after acute renal ischemia-reperfusion." | 3.83 | Metformin alleviated EMT and fibrosis after renal ischemia-reperfusion injury in rats. ( Chen, Z; Guo, J; Jiang, G; Liu, X; Wang, M; Weng, X, 2016) |
| "Here, we have investigated the effect of metformin pretreatment in the rat models of global cerebral ischemia." | 3.80 | Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: interference of AMPK/PGC-1α pathway. ( Ashabi, G; Goudarzvand, M; Khalaj, L; Khodagholi, F; Nasiri, M, 2014) |
| "Metformin was administered to rats orally by gavage 500 mg/kg once daily for one week before induction of cerebral ischemia (rats were subjected to 30 min of ischemia before decapitation) and ischemia/reperfusion (rats were subjected to 30 min of ischemia then 60 minutes of reperfusion before decapitation)." | 3.80 | Modulation of the oxidative stress by metformin in the cerebrum of rats exposed to global cerebral ischemia and ischemia/reperfusion. ( Abd-Elsameea, AA; Mohamed, AM; Moustaf, AA, 2014) |
| "Metformin is a biguanide drug that exerts strong effects on multiple diseases." | 1.91 | Metformin protects against retinal ischemia/reperfusion injury through AMPK-mediated mitochondrial fusion. ( Han, XJ; Jiang, LP; Qu, XH; Sun, GF; Tou, FF; Wang, T; Xiao, JX; Zhang, K, 2023) |
| "Metformin (MET) has been the subject of many classic studies in possessing antiapoptotic, anti-inflammatory, antioxidation activities and antiviral." | 1.72 | Metformin protects against pericyte apoptosis and promotes neurogenesis through suppressing JNK p38 MAPK signalling activation in ischemia/reperfusion injury. ( Cui, K; Fu, X; Liu, C; Lu, Z; Man, J; Wang, J; Zhang, D; Zhang, Z, 2022) |
| "Then, stroke was induced by transient middle cerebral artery occlusion (tMCAO)." | 1.72 | Effects of co-administration of metformin and evogliptin on cerebral infarct volume in the diabetic rat. ( Hong, JM; Joe, EH; Lee, JS; Lee, SJ; Yoon, BS, 2022) |
| "Metformin (Met) is a commonly used drug in the treatment of type 2 diabetes." | 1.62 | Neuroprotective effects of metformin on cerebral ischemia-reperfusion injury by regulating PI3K/Akt pathway. ( Gao, J; Guo, H; Li, X; Liu, Z; Lv, H; Ruan, C; Wang, Y; Yan, J, 2021) |
| "Rats underwent cerebral ischemia/reperfusion and MET was administered orally at doses of 100 and 200 mg/kg for 56 days." | 1.56 | Long-term metformin therapy improves neurobehavioral functions and antioxidative activity after cerebral ischemia/reperfusion injury in rats. ( Allahtavakoli, M; Esmaeil-Moghaddam, S; Fatemi, I; Hakimizadeh, E; Kaeidi, A; Pak-Hashemi, M; Saeed-Askari, P, 2020) |
| "Metformin has anti-oxidative properties and protects against I/R injury." | 1.56 | Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway. ( Cui, R; Feng, Y; Jia, Y; Li, Z; Liu, C; Qu, K; Tong, Y; Wang, C; Zhang, J, 2020) |
| "Pretreatment with metformin in I/R animals reduced levels of pro-BDNF compared with the I/R group (p < 0." | 1.43 | Metformin pretreatment enhanced learning and memory in cerebral forebrain ischaemia: the role of the AMPK/BDNF/P70SK signalling pathway. ( Ashabi, G; Ghadernezhad, N; Khalaj, L; Mirmasoumi, M; Pazoki-Toroudi, H, 2016) |
| "Myocardial infarction is the most common cause of death in these patients." | 1.43 | Mortality reduction among persons with type 2 diabetes: (-)-Epicatechin as add-on therapy to metformin? ( Moreno-Ulloa, A; Moreno-Ulloa, J, 2016) |
| "Metformin has a protective effect against I/R injury on the testis." | 1.43 | Protective effect of metformin on testicular ischemia/reperfusion injury in rats. ( Akbari, G; Asghari, A; Meghdadi, A; Mortazavi, P, 2016) |
| "Nonalcoholic fatty liver disease is associated with chronic oxidative stress." | 1.42 | Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation. ( Burian, M; Cahova, M; Cervinkova, Z; Dankova, H; Drahota, Z; Gladkova, C; Kazdova, L; Krizova, J; Kucera, O; Oliyarnyk, O; Palenickova, E; Papackova, Z; Sticova, E; Stopka, P, 2015) |
| "Biguanides also inhibit mitochondrial ATP synthase, and two of them inhibit only ATP hydrolysis, not synthesis." | 1.40 | Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria. ( Bridges, HR; Hirst, J; Jones, AJ; Pollak, MN, 2014) |
| "Metformin pretreatment at doses of 200 and 300 mg/kg significantly increased skin flap survival rate." | 1.40 | Metformin improves skin flap survival through nitric oxide system. ( Abbasi, A; Dehpour, AR; Ejtemaei-Mehr, S; Moghaddas, P; Rahimi Balaei, M; Rahimpour, S; Taleb, S, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (6.38) | 29.6817 |
| 2010's | 26 (55.32) | 24.3611 |
| 2020's | 18 (38.30) | 2.80 |
| Authors | Studies |
|---|---|
| Ruan, C | 1 |
| Guo, H | 1 |
| Gao, J | 1 |
| Wang, Y | 4 |
| Liu, Z | 3 |
| Yan, J | 1 |
| Li, X | 12 |
| Lv, H | 1 |
| Lee, SJ | 1 |
| Yoon, BS | 1 |
| Hong, JM | 1 |
| Joe, EH | 1 |
| Lee, JS | 1 |
| Liu, C | 5 |
| Zhang, D | 3 |
| Lu, Z | 1 |
| Man, J | 1 |
| Zhang, Z | 1 |
| Fu, X | 1 |
| Cui, K | 1 |
| Wang, J | 5 |
| Zhang, K | 1 |
| Wang, T | 2 |
| Sun, GF | 1 |
| Xiao, JX | 1 |
| Jiang, LP | 1 |
| Tou, FF | 1 |
| Qu, XH | 1 |
| Han, XJ | 1 |
| Wu, Z | 1 |
| Bai, Y | 2 |
| Qi, Y | 2 |
| Chang, C | 1 |
| Jiao, Y | 1 |
| Guo, Z | 1 |
| Topcu, A | 1 |
| Balik, G | 1 |
| Atak, M | 1 |
| Mercantepe, T | 1 |
| Uydu, HA | 1 |
| Tumkaya, L | 1 |
| Sarıbal, D | 1 |
| Erdem, E | 1 |
| Güngör-Ordueri, NE | 1 |
| Usta, A | 1 |
| Karakuş, C | 1 |
| Karacan, M | 1 |
| Li, C | 2 |
| Mu, N | 1 |
| Gu, C | 1 |
| Liu, M | 1 |
| Yang, Z | 1 |
| Yin, Y | 1 |
| Chen, M | 1 |
| Han, Y | 1 |
| Yu, L | 1 |
| Ma, H | 2 |
| Wang, L | 3 |
| Yang, X | 3 |
| Huang, C | 1 |
| Jia, Y | 1 |
| Cui, R | 1 |
| Wang, C | 4 |
| Feng, Y | 1 |
| Li, Z | 4 |
| Tong, Y | 1 |
| Qu, K | 1 |
| Zhang, J | 4 |
| Fatemi, I | 1 |
| Saeed-Askari, P | 1 |
| Hakimizadeh, E | 1 |
| Kaeidi, A | 1 |
| Esmaeil-Moghaddam, S | 1 |
| Pak-Hashemi, M | 1 |
| Allahtavakoli, M | 1 |
| Huijink, TM | 1 |
| Venema, LH | 1 |
| Posma, RA | 1 |
| de Vries, NJ | 1 |
| Westerkamp, AC | 1 |
| Ottens, PJ | 1 |
| Touw, DJ | 1 |
| Nijsten, MW | 1 |
| Leuvenink, HGD | 1 |
| Palee, S | 1 |
| Higgins, L | 1 |
| Leech, T | 2 |
| Chattipakorn, SC | 2 |
| Chattipakorn, N | 2 |
| Ding, R | 1 |
| Wu, W | 2 |
| Sun, Z | 2 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 4 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
| Buan, MEM | 1 |
| Flox, C | 1 |
| Chavan, S | 1 |
| Shi, X | 1 |
| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
| Tammeveski, K | 1 |
| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
| Veziroglu, E | 1 |
| Iranzo, A | 1 |
| M Kannan, A | 1 |
| Arunamata, A | 1 |
| Tacy, TA | 1 |
| Kache, S | 1 |
| Mainwaring, RD | 1 |
| Ma, M | 1 |
| Maeda, K | 1 |
| Punn, R | 1 |
| Noguchi, S | 1 |
| Hahn, S | 3 |
| Iwasa, Y | 3 |
| Ling, J | 2 |
| Voccio, JP | 2 |
| Kim, Y | 3 |
| Song, J | 3 |
| Bascuñán, J | 2 |
| Chu, Y | 1 |
| Tomita, M | 1 |
| Cazorla, M | 1 |
| Herrera, E | 1 |
| Palomeque, E | 1 |
| Saud, N | 1 |
| Hoplock, LB | 1 |
| Lobchuk, MM | 1 |
| Lemoine, J | 1 |
| Henson, MA | 1 |
| Unsihuay, D | 1 |
| Qiu, J | 1 |
| Swaroop, S | 1 |
| Nagornov, KO | 1 |
| Kozhinov, AN | 1 |
| Tsybin, YO | 1 |
| Kuang, S | 1 |
| Laskin, J | 1 |
| Zin, NNINM | 1 |
| Mohamad, MN | 1 |
| Roslan, K | 1 |
| Abdul Wafi, S | 1 |
| Abdul Moin, NI | 1 |
| Alias, A | 1 |
| Zakaria, Y | 1 |
| Abu-Bakar, N | 1 |
| Naveed, A | 1 |
| Jilani, K | 1 |
| Siddique, AB | 1 |
| Akbar, M | 1 |
| Riaz, M | 1 |
| Mushtaq, Z | 1 |
| Sikandar, M | 1 |
| Ilyas, S | 1 |
| Bibi, I | 1 |
| Asghar, A | 1 |
| Rasool, G | 1 |
| Irfan, M | 1 |
| Li, XY | 1 |
| Zhao, S | 1 |
| Fan, XH | 1 |
| Chen, KP | 1 |
| Hua, W | 1 |
| Liu, ZM | 1 |
| Xue, XD | 1 |
| Zhou, B | 1 |
| Zhang, S | 2 |
| Xing, YL | 1 |
| Chen, MA | 1 |
| Sun, Y | 2 |
| Neradilek, MB | 1 |
| Wu, XT | 1 |
| Huang, W | 1 |
| Cui, Y | 1 |
| Yang, QQ | 1 |
| Li, HW | 1 |
| Zhao, XQ | 1 |
| Hossein Rashidi, B | 1 |
| Tarafdari, A | 1 |
| Ghazimirsaeed, ST | 1 |
| Shahrokh Tehraninezhad, E | 1 |
| Keikha, F | 1 |
| Eslami, B | 1 |
| Ghazimirsaeed, SM | 1 |
| Jafarabadi, M | 1 |
| Silvani, Y | 1 |
| Lovita, AND | 1 |
| Maharani, A | 1 |
| Wiyasa, IWA | 1 |
| Sujuti, H | 1 |
| Ratnawati, R | 1 |
| Raras, TYM | 1 |
| Lemin, AS | 1 |
| Rahman, MM | 1 |
| Pangarah, CA | 1 |
| Kiyu, A | 1 |
| Zeng, C | 2 |
| Du, H | 1 |
| Lin, D | 1 |
| Jalan, D | 1 |
| Rubagumya, F | 1 |
| Hopman, WM | 1 |
| Vanderpuye, V | 1 |
| Lopes, G | 1 |
| Seruga, B | 1 |
| Booth, CM | 1 |
| Berry, S | 1 |
| Hammad, N | 1 |
| Sajo, EA | 1 |
| Okunade, KS | 1 |
| Olorunfemi, G | 1 |
| Rabiu, KA | 1 |
| Anorlu, RI | 1 |
| Xu, C | 2 |
| Xiang, Y | 1 |
| Xu, X | 1 |
| Zhou, L | 2 |
| Dong, X | 1 |
| Tang, S | 1 |
| Gao, XC | 1 |
| Wei, CH | 1 |
| Zhang, RG | 1 |
| Cai, Q | 1 |
| He, Y | 1 |
| Tong, F | 1 |
| Dong, JH | 1 |
| Wu, G | 1 |
| Dong, XR | 1 |
| Tang, X | 1 |
| Tao, F | 1 |
| Xiang, W | 1 |
| Zhao, Y | 2 |
| Jin, L | 1 |
| Tao, H | 1 |
| Lei, Y | 1 |
| Gan, H | 1 |
| Huang, Y | 1 |
| Chen, Y | 3 |
| Chen, L | 3 |
| Shan, A | 1 |
| Zhao, H | 2 |
| Wu, M | 2 |
| Ma, Q | 1 |
| Zhang, E | 1 |
| Li, Y | 5 |
| Xue, F | 1 |
| Deng, L | 1 |
| Liu, L | 2 |
| Yan, Z | 2 |
| Meng, J | 1 |
| Chen, G | 2 |
| Anastassiadou, M | 1 |
| Bernasconi, G | 1 |
| Brancato, A | 1 |
| Carrasco Cabrera, L | 1 |
| Greco, L | 1 |
| Jarrah, S | 1 |
| Kazocina, A | 1 |
| Leuschner, R | 1 |
| Magrans, JO | 1 |
| Miron, I | 1 |
| Nave, S | 1 |
| Pedersen, R | 1 |
| Reich, H | 1 |
| Rojas, A | 1 |
| Sacchi, A | 1 |
| Santos, M | 1 |
| Theobald, A | 1 |
| Vagenende, B | 1 |
| Verani, A | 1 |
| Du, L | 1 |
| Liu, X | 2 |
| Ren, Y | 1 |
| Li, J | 7 |
| Li, P | 1 |
| Jiao, Q | 1 |
| Meng, P | 1 |
| Wang, F | 2 |
| Wang, YS | 1 |
| Zhou, X | 2 |
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| Hou, J | 1 |
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| Lee, DF | 1 |
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| Wen, L | 1 |
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| Xie, X | 1 |
| Zhao, Q | 1 |
| Hu, W | 2 |
| Zhang, Y | 4 |
| Wu, X | 1 |
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| Li, M | 1 |
| Li, W | 3 |
| Du, F | 1 |
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| Cho, CH | 1 |
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| Huang, H | 1 |
| Wei, Y | 2 |
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| Na, KJ | 1 |
| Choi, H | 1 |
| Oh, HR | 1 |
| Kim, YH | 1 |
| Lee, SB | 1 |
| Jung, YJ | 1 |
| Koh, J | 1 |
| Park, S | 1 |
| Lee, HJ | 1 |
| Jeon, YK | 1 |
| Chung, DH | 1 |
| Paeng, JC | 1 |
| Park, IK | 1 |
| Kang, CH | 1 |
| Cheon, GJ | 1 |
| Kang, KW | 1 |
| Lee, DS | 1 |
| Kim, YT | 1 |
| Pajuelo-Lozano, N | 1 |
| Alcalá, S | 1 |
| Sainz, B | 1 |
| Perona, R | 1 |
| Sanchez-Perez, I | 1 |
| Logotheti, S | 1 |
| Marquardt, S | 1 |
| Gupta, SK | 1 |
| Richter, C | 1 |
| Edelhäuser, BAH | 1 |
| Engelmann, D | 1 |
| Brenmoehl, J | 1 |
| Söhnchen, C | 1 |
| Murr, N | 1 |
| Alpers, M | 1 |
| Singh, KP | 1 |
| Wolkenhauer, O | 1 |
| Heckl, D | 1 |
| Spitschak, A | 1 |
| Pützer, BM | 1 |
| Liao, Y | 1 |
| Cheng, J | 1 |
| Kong, X | 1 |
| Li, S | 1 |
| Zhang, M | 4 |
| Zhang, H | 2 |
| Yang, T | 2 |
| Dong, Y | 1 |
| Xu, Y | 1 |
| Yuan, Z | 1 |
| Cao, J | 1 |
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| Luo, Z | 1 |
| Mei, Z | 1 |
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| Liang, C | 1 |
| Yang, H | 1 |
| Song, Y | 1 |
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| Qian, J | 1 |
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| Liu, Y | 5 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Dipeptidyl-4 Inhibitors in Reducing Stroke Severity, From the Health Insurance Review and Assessment Service Database[NCT05817097] | 22,119 participants (Anticipated) | Observational | 2023-08-31 | Not yet recruiting | |||
| Can Metformin Prevent Endothelial Ischemia and Reperfusion Injury? The Metformin-FMD Trial[NCT01610401] | Phase 4 | 26 participants (Actual) | Interventional | 2012-05-31 | Completed | ||
| A Randomized Phase 3 Trial of Metformin in Patients Initiating Androgen Deprivation Therapy as Prevention and Intervention of Metabolic Syndrome: The Prime Study[NCT03031821] | Phase 3 | 168 participants (Actual) | Interventional | 2018-07-12 | Terminated (stopped due to Manufacturer discontinued the production of study drugs.) | ||
| Use of Metformin in Prevention and Treatment of Cardiac Fibrosis in PAI-1 Deficient Population[NCT05317806] | Phase 4 | 15 participants (Anticipated) | Interventional | 2022-10-10 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for metformin and Reperfusion Injury
| Article | Year |
|---|---|
AMP-activated protein kinase: An attractive therapeutic target for ischemia-reperfusion injury.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Apoptosis; Energy Metabolism; Humans; Hypoglyce | 2020 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
The beneficial roles of metformin on the brain with cerebral ischaemia/reperfusion injury.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Diabetes Mellitus; Humans; Hypoglycemic Agents; Metformin | 2019 |
[Role of AMP-activated protein kinase in renal ischemic preconditioning].
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Energy Metabolism; Enzyme Activa | 2014 |
The emerging role of Toll-like receptor 4 in myocardial inflammation.
Topics: Animals; Cardiotonic Agents; Clinical Trials as Topic; Disaccharides; Follistatin; Gene Expression R | 2016 |
[Hypoglycemic therapy in heart disease patients with type 2 diabetes mellitus].
Topics: Administration, Oral; Aged; Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Human | 2010 |
2 trials available for metformin and Reperfusion Injury
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Impact of metformin on endothelial ischemia-reperfusion injury in humans in vivo: a prospective randomized open, blinded-endpoint study.
Topics: Adult; Brachial Artery; Endothelium, Vascular; Female; Forearm; Humans; Hypoglycemic Agents; Male; M | 2014 |
40 other studies available for metformin and Reperfusion Injury
| Article | Year |
|---|---|
Neuroprotective effects of metformin on cerebral ischemia-reperfusion injury by regulating PI3K/Akt pathway.
Topics: Animals; Apoptosis; Brain Ischemia; Diabetes Mellitus, Type 2; Infarction, Middle Cerebral Artery; M | 2021 |
Effects of co-administration of metformin and evogliptin on cerebral infarct volume in the diabetic rat.
Topics: Animals; Brain Chemistry; Cerebral Infarction; Cerebrovascular Circulation; Diabetes Mellitus, Exper | 2022 |
Metformin protects against pericyte apoptosis and promotes neurogenesis through suppressing JNK p38 MAPK signalling activation in ischemia/reperfusion injury.
Topics: Animals; Apoptosis; Brain Ischemia; Caspase 3; Infarction, Middle Cerebral Artery; MAP Kinase Signal | 2022 |
Metformin protects against retinal ischemia/reperfusion injury through AMPK-mediated mitochondrial fusion.
Topics: AMP-Activated Protein Kinases; Apoptosis; Humans; Metformin; Mitochondrial Dynamics; Reactive Oxygen | 2023 |
Metformin ameliorates ferroptosis in cardiac ischemia and reperfusion by reducing NOX4 expression via promoting AMPKα.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Cell Line; Ferroptosis; Iron; Ischemia; Metformin | 2023 |
An investigation of the effects of metformin on ovarian ischemia-reperfusion injury in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Caspase 3; Estradiol; Female; Glutathione; Malondia | 2019 |
Metformin decreases testicular damages following ischaemia/reperfusion injury in rats.
Topics: Animals; Apoptosis; Caspase 3; Drug Evaluation, Preclinical; Hypoglycemic Agents; Male; Metformin; R | 2020 |
Metformin mediates cardioprotection against aging-induced ischemic necroptosis.
Topics: Aging; Animals; Autophagy; GTPase-Activating Proteins; Humans; Hypoglycemic Agents; Imidazoles; Indo | 2020 |
Metformin Attenuates Ischemia-reperfusion Injury of Fatty Liver in Rats Through Inhibition of the TLR4/NF-κB Axis
Topics: Animals; Fatty Liver; Hypoglycemic Agents; Metformin; Protective Factors; Rats; Rats, Sprague-Dawley | 2020 |
Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway.
Topics: Animals; Caco-2 Cells; Carrier Proteins; Humans; Intracellular Signaling Peptides and Proteins; Metf | 2020 |
Long-term metformin therapy improves neurobehavioral functions and antioxidative activity after cerebral ischemia/reperfusion injury in rats.
Topics: Animals; Antioxidants; Brain Ischemia; Dose-Response Relationship, Drug; Drug Administration Schedul | 2020 |
Metformin Preconditioning and Postconditioning to Reduce Ischemia Reperfusion Injury in an Isolated Ex Vivo Rat and Porcine Kidney Normothermic Machine Perfusion Model.
Topics: Animals; Female; Kidney; Kidney Transplantation; Male; Metformin; Models, Animal; Necrosis; Nephrect | 2021 |
Acute metformin treatment provides cardioprotection via improved mitochondrial function in cardiac ischemia / reperfusion injury.
Topics: Animals; Apoptosis; Arrhythmias, Cardiac; Cardiotonic Agents; Heart Function Tests; Hypoglycemic Age | 2020 |
Metformin and myocardial ischemia and reperfusion injury: Moving toward "prime time" human use?
Topics: Humans; Metformin; Myocardial Ischemia; Myocardial Reperfusion Injury; Reperfusion Injury | 2021 |
Pharmacological preconditioning protects from ischemia/reperfusion-induced apoptosis by modulating Bcl-xL expression through a ROS-dependent mechanism.
Topics: Animals; Apoptosis; bcl-X Protein; Cell Survival; Humans; Hypoglycemic Agents; Metformin; Myocardial | 2021 |
Metformin reduces ovarian ischemia reperfusion injury in rats by improving oxidative/nitrosative stress.
Topics: Animals; Antioxidants; Disease Models, Animal; Female; Metformin; Nitrosative Stress; Ovarian Torsio | 2021 |
Metformin regulates the Th17/Treg balance by glycolysis with TIGAR in hepatic ischemia-reperfusion injury.
Topics: Animals; Apoptosis Regulatory Proteins; Disease Models, Animal; Energy Metabolism; Glycolysis; Hepat | 2021 |
Effect of metformin on germ cell-specific apoptosis, oxidative stress and epididymal sperm quality after testicular torsion/detorsion in rats.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Caspase 3; Catalase; Disease Models, Animal; Enzy | 2018 |
Hypothermic machine perfusion with metformin-University of Wisconsin solution for
Topics: Adenosine; Alanine Transaminase; Allopurinol; AMP-Activated Protein Kinases; Animals; Aspartate Amin | 2017 |
What is the protective effect of metformin on rat ovary against ischemia-reperfusion injury?
Topics: Animals; Caspase 3; Female; Glutathione; Metformin; Ovary; Protective Agents; Rats; Rats, Wistar; Re | 2018 |
Synergistic effect of rapamycin and metformin against germ cell apoptosis and oxidative stress after testicular torsion/detorsion-induced ischemia/reperfusion in rats.
Topics: Animals; Apoptosis; Drug Synergism; Male; Metformin; Oxidative Stress; Rats, Wistar; Reperfusion Inj | 2018 |
Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: interference of AMPK/PGC-1α pathway.
Topics: Adenylate Kinase; Animals; Apoptosis; Brain; Brain Ischemia; Dose-Response Relationship, Drug; Drug | 2014 |
Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria.
Topics: Animals; Antimalarials; Antineoplastic Agents; Biguanides; Cattle; Diabetes Mellitus, Type 2; Electr | 2014 |
Metformin improves skin flap survival through nitric oxide system.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Graft Survival; Hypoglycemic Agen | 2014 |
Modulation of the oxidative stress by metformin in the cerebrum of rats exposed to global cerebral ischemia and ischemia/reperfusion.
Topics: Animals; Brain Ischemia; Catalase; Cerebrum; Glutathione Peroxidase; Male; Malondialdehyde; Metformi | 2014 |
Metformin treatment in the period after stroke prevents nitrative stress and restores angiogenic signaling in the brain in diabetes.
Topics: Animals; Apoptosis; Brain; Diabetes Mellitus; Metformin; Neovascularization, Physiologic; p38 Mitoge | 2015 |
Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cytoprotection; | 2015 |
Metformin attenuated the inflammation after renal ischemia/reperfusion and suppressed apoptosis of renal tubular epithelial cell in rats.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Blood Urea Nitrogen; Blotting, Western; Caspase 3 | 2015 |
Metformin alleviated EMT and fibrosis after renal ischemia-reperfusion injury in rats.
Topics: Animals; Epithelial-Mesenchymal Transition; Fibrosis; Kidney; Male; Metformin; Random Allocation; Ra | 2016 |
Metformin pretreatment enhanced learning and memory in cerebral forebrain ischaemia: the role of the AMPK/BDNF/P70SK signalling pathway.
Topics: AMP-Activated Protein Kinases; Animals; Behavior, Animal; Brain Ischemia; Brain-Derived Neurotrophic | 2016 |
Mortality reduction among persons with type 2 diabetes: (-)-Epicatechin as add-on therapy to metformin?
Topics: Animals; Cardiovascular Diseases; Catechin; Chocolate; Clinical Trials as Topic; Diabetes Mellitus, | 2016 |
Protective effect of metformin on testicular ischemia/reperfusion injury in rats.
Topics: Animals; Male; Malondialdehyde; Metformin; Models, Animal; Oxidative Stress; Peroxidase; Protective | 2016 |
Effects of melatonin and metformin co-administration on testicular ischemia/reperfusion injury in rats.
Topics: Animals; Antioxidants; Drug Therapy, Combination; Male; Melatonin; Metformin; Random Allocation; Rat | 2016 |
Metformin protects the brain against ischemia/reperfusion injury through PI3K/Akt1/JNK3 signaling pathways in rats.
Topics: Animals; Anxiety; Apoptosis; Brain Ischemia; CA1 Region, Hippocampal; Caspase 3; Cognition Disorders | 2017 |
Subchronic metformin pretreatment enhances novel object recognition memory task in forebrain ischemia: behavioural, molecular, and electrophysiological studies.
Topics: AMP-Activated Protein Kinases; Animals; Brain Ischemia; Cognitive Dysfunction; Cyclic AMP Response E | 2017 |
Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia.
Topics: Acute Kidney Injury; AMP-Activated Protein Kinases; Animals; Antimetabolites; Antimycin A; Cell Line | 2011 |
A novel cardioprotective agent in cardiac transplantation: metformin activation of AMP-activated protein kinase decreases acute ischemia-reperfusion injury and chronic rejection.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Cardiotonic Agents; E | 2011 |
Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling.
Topics: Adenylate Kinase; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diabetes Mellitus; Gene Del | 2008 |
Metformin induces cardioprotection against ischaemia/reperfusion injury in the rat heart 24 hours after administration.
Topics: AMP-Activated Protein Kinases; Animals; Hypoglycemic Agents; Male; Metformin; Multienzyme Complexes; | 2008 |
Metformin improves cardiac functional recovery after ischemia in rats.
Topics: Animals; Cardiac Output; Hypoglycemic Agents; In Vitro Techniques; Male; Metformin; Myocardial Ische | 2002 |