Page last updated: 2024-10-30

metformin and Psoriasis

metformin has been researched along with Psoriasis in 12 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Psoriasis: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.

Research Excerpts

ExcerptRelevanceReference
"Single centre, parallel group, randomized, study of metformin, pioglitazone and placebo in psoriasis patients with MS."9.22Randomized placebo control study of insulin sensitizers (Metformin and Pioglitazone) in psoriasis patients with metabolic syndrome (Topical Treatment Cohort). ( Bhansali, A; Singh, S, 2016)
"The safety of metformin usage by diabetic psoriasis patients is unclear."7.91Safety of Metformin in Psoriasis Patients With Diabetes Mellitus: A 17-Year Population-Based Real-World Cohort Study. ( Chen, TH; Chi, CC; Chiu, WT; Hsu, CY; Lin, YS; Su, YJ, 2019)
"Bexarotene (BEX) is a specific RXR agonist and an antineoplastic agent indicated by the FDA for cutaneous T-cell lymphoma (CTLA)."5.91Design, synthesis and characterization of a novel multicomponent salt of bexarotene with metformin and application in ameliorating psoriasis with T2DM. ( An, Q; Du, G; Hao, Y; Li, W; Lu, Y; Ren, L; Wang, J; Yang, D; Yang, H; Yang, Y; Yu, M; Zhang, S; Zhang, Y, 2023)
"Single centre, parallel group, randomized, study of metformin, pioglitazone and placebo in psoriasis patients with MS."5.22Randomized placebo control study of insulin sensitizers (Metformin and Pioglitazone) in psoriasis patients with metabolic syndrome (Topical Treatment Cohort). ( Bhansali, A; Singh, S, 2016)
"The current evidence demonstrates therapeutic efficacy of pioglitazone, which may be a treatment option in patients with psoriasis and diabetes mellitus."5.12Effects of antidiabetic drugs on psoriasis: A meta-analysis. ( Chi, CC; Lee, CY; Liu, CY; Tien O'Donnell, F; Tung, TH; Wang, SH, 2021)
"The safety of metformin usage by diabetic psoriasis patients is unclear."3.91Safety of Metformin in Psoriasis Patients With Diabetes Mellitus: A 17-Year Population-Based Real-World Cohort Study. ( Chen, TH; Chi, CC; Chiu, WT; Hsu, CY; Lin, YS; Su, YJ, 2019)
"After treatment of psoriasis patients with a traditional anti-psoriatic drug in combination with metformin and peroxisome proliferator-activated receptor gamma (PPARɤ) agonist (pioglitazone), the CD4+ T cells, IL-2, CRP, CP, ALT and AST levels were statistically significantly decreased compared to psoriasis patients without treatment."3.85Mechanism of action and effect of immune-modulating agents in the treatment of psoriasis. ( Ahmed, AS; Al-Najjar, AH; El-Gharabawy, RM, 2017)
"Bexarotene (BEX) is a specific RXR agonist and an antineoplastic agent indicated by the FDA for cutaneous T-cell lymphoma (CTLA)."1.91Design, synthesis and characterization of a novel multicomponent salt of bexarotene with metformin and application in ameliorating psoriasis with T2DM. ( An, Q; Du, G; Hao, Y; Li, W; Lu, Y; Ren, L; Wang, J; Yang, D; Yang, H; Yang, Y; Yu, M; Zhang, S; Zhang, Y, 2023)
"Psoriasis is an autoimmune inflammatory skin disorder consists of hyperkeratosis, abnormal keratinization, acanthosis, and infiltration of inflammatory cells in the dermis."1.62Co-encapsulation of metformin and ginger into the liposomes: ( Jenabikordi, K; Rezaie, A; Zadeh, BSM, 2021)
"Psoriasis is a prevalent, chronic inflammatory skin disease that arises from rapid and excessive growth of keratinocytes induced by abnormal inflammatory responses."1.51Metformin inhibits pro-inflammatory responses via targeting nuclear factor-κB in HaCaT cells. ( Ba, W; Chi, S; Li, C; Wang, R; Wang, Y; Xu, Y; Yang, J; Yin, G, 2019)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (25.00)29.6817
2010's5 (41.67)24.3611
2020's4 (33.33)2.80

Authors

AuthorsStudies
Jenabikordi, K1
Zadeh, BSM1
Rezaie, A1
Yang, Y1
Yu, M1
Ren, L1
An, Q1
Li, W1
Yang, H1
Zhang, Y1
Zhang, S1
Hao, Y1
Du, G1
Yang, D1
Lu, Y1
Wang, J1
Chi, CC2
Lee, CY1
Liu, CY1
Wang, SH1
Tien O'Donnell, F1
Tung, TH1
Chang, JE1
Choi, MS1
Ba, W1
Xu, Y1
Yin, G1
Yang, J1
Wang, R1
Chi, S1
Wang, Y1
Li, C1
Su, YJ1
Chen, TH1
Hsu, CY1
Chiu, WT1
Lin, YS1
Kim, SC1
Schneeweiss, S1
Glynn, RJ1
Doherty, M1
Goldfine, AB1
Solomon, DH1
Singh, S1
Bhansali, A1
El-Gharabawy, RM1
Ahmed, AS1
Al-Najjar, AH1
Koca, R1
Altinyazar, HC1
Yenidünya, S1
Tekin, NS1
Brauchli, YB1
Jick, SS1
Curtin, F1
Meier, CR1
Moore, AF1
Soper, T1
Jones, N1
Grevelink, J1
Abourizk, N1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Metformin for Treatment of Psoriasis Combined With Disorders of Glucose and Lipid Metabolism: A Double-Blind, Randomized, Placebo-Controlled Study[NCT03629639]Phase 480 participants (Anticipated)Interventional2018-09-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for metformin and Psoriasis

ArticleYear
Effects of antidiabetic drugs on psoriasis: A meta-analysis.
    European journal of clinical investigation, 2021, Volume: 51, Issue:2

    Topics: Humans; Hypoglycemic Agents; Liraglutide; Metformin; Pioglitazone; Psoriasis; Rosiglitazone; Treatme

2021
A Molecular Perspective on the Potential Benefits of Metformin for the Treatment of Inflammatory Skin Disorders.
    International journal of molecular sciences, 2020, Nov-25, Volume: 21, Issue:23

    Topics: Acanthosis Nigricans; Acne Vulgaris; Dermatitis, Allergic Contact; Hidradenitis Suppurativa; Humans;

2020

Trials

1 trial available for metformin and Psoriasis

ArticleYear
Randomized placebo control study of insulin sensitizers (Metformin and Pioglitazone) in psoriasis patients with metabolic syndrome (Topical Treatment Cohort).
    BMC dermatology, 2016, 08-17, Volume: 16, Issue:1

    Topics: Adult; Aged; Analysis of Variance; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; M

2016

Other Studies

9 other studies available for metformin and Psoriasis

ArticleYear
Co-encapsulation of metformin and ginger into the liposomes:
    Drug development and industrial pharmacy, 2021, Volume: 47, Issue:9

    Topics: Administration, Cutaneous; Animals; Liposomes; Metformin; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2021
Design, synthesis and characterization of a novel multicomponent salt of bexarotene with metformin and application in ameliorating psoriasis with T2DM.
    International journal of pharmaceutics, 2023, Nov-05, Volume: 646

    Topics: Animals; Bexarotene; Diabetes Mellitus, Type 2; Drug Combinations; Humans; Imiquimod; Metformin; Mic

2023
Metformin inhibits pro-inflammatory responses via targeting nuclear factor-κB in HaCaT cells.
    Cell biochemistry and function, 2019, Volume: 37, Issue:1

    Topics: Cells, Cultured; Dose-Response Relationship, Drug; Humans; Hypoglycemic Agents; Inflammation; Metfor

2019
Safety of Metformin in Psoriasis Patients With Diabetes Mellitus: A 17-Year Population-Based Real-World Cohort Study.
    The Journal of clinical endocrinology and metabolism, 2019, 08-01, Volume: 104, Issue:8

    Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Hospitalization; Humans; Hypoglycemic Agents; Male;

2019
Dipeptidyl peptidase-4 inhibitors in type 2 diabetes may reduce the risk of autoimmune diseases: a population-based cohort study.
    Annals of the rheumatic diseases, 2015, Volume: 74, Issue:11

    Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Cohort Studies; Diabetes Mellitus, Type 2; Dipeptidyl-Pe

2015
Mechanism of action and effect of immune-modulating agents in the treatment of psoriasis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 85

    Topics: Adrenal Cortex Hormones; Adult; Cholecalciferol; Coal Tar; Drug Therapy, Combination; Female; Humans

2017
Psoriasiform drug eruption associated with metformin hydrochloride: a case report.
    Dermatology online journal, 2003, Volume: 9, Issue:3

    Topics: Adolescent; Biopsy; Drug Eruptions; Female; Humans; Hypoglycemic Agents; Metformin; Psoriasis

2003
Association between use of thiazolidinediones or other oral antidiabetics and psoriasis: A population based case-control study.
    Journal of the American Academy of Dermatology, 2008, Volume: 58, Issue:3

    Topics: Administration, Oral; Adult; Aged; Case-Control Studies; Databases, Factual; Drug Administration Sch

2008
Psoriatic exacerbation associated with insulin therapy.
    Diabetes care, 2008, Volume: 31, Issue:5

    Topics: Aged; Diabetes Mellitus, Type 2; Disease Progression; Humans; Hypoglycemic Agents; Insulin; Insulin

2008