metformin has been researched along with Proteinuria in 4 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Proteinuria: The presence of proteins in the urine, an indicator of KIDNEY DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin has been reported to decrease insulin resistance and is associated with a lower risk of pregnancy-induced hypertension and preeclampsia." | 7.91 | Effect of Metformin on a Preeclampsia-Like Mouse Model Induced by High-Fat Diet. ( Cao, G; Cao, X; Li, L; Wang, F; Yi, W, 2019) |
| "Metformin has protective effects on diabetic nephropathy." | 5.62 | Metformin reduces proteinuria in spontaneously hypertensive rats by activating the HIF-2α-VEGF-A pathway. ( Cai, W; Fu, Y; Hong, L; Liu, T; Qiao, X; Wang, M; Yang, Y; Zheng, Z; Zhong, M, 2021) |
| "Metformin has been reported to decrease insulin resistance and is associated with a lower risk of pregnancy-induced hypertension and preeclampsia." | 3.91 | Effect of Metformin on a Preeclampsia-Like Mouse Model Induced by High-Fat Diet. ( Cao, G; Cao, X; Li, L; Wang, F; Yi, W, 2019) |
| "Metformin has protective effects on diabetic nephropathy." | 1.62 | Metformin reduces proteinuria in spontaneously hypertensive rats by activating the HIF-2α-VEGF-A pathway. ( Cai, W; Fu, Y; Hong, L; Liu, T; Qiao, X; Wang, M; Yang, Y; Zheng, Z; Zhong, M, 2021) |
| "Diabetic nephropathy is one of the most common and serious complications of diabetes mellitus." | 1.48 | Ameliorative effects of protodioscin on experimental diabetic nephropathy. ( Dong, Y; Guo, C; Liu, Y; Xie, G; Zhu, H, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, F | 1 |
| Cao, G | 1 |
| Yi, W | 1 |
| Li, L | 1 |
| Cao, X | 1 |
| Liu, T | 1 |
| Hong, L | 1 |
| Yang, Y | 1 |
| Qiao, X | 1 |
| Cai, W | 1 |
| Zhong, M | 1 |
| Wang, M | 1 |
| Zheng, Z | 1 |
| Fu, Y | 1 |
| Guo, C | 1 |
| Dong, Y | 1 |
| Zhu, H | 1 |
| Liu, Y | 1 |
| Xie, G | 1 |
| Nistala, R | 1 |
| Raja, A | 1 |
| Pulakat, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Preeclampsia Intervention 4 - A Triple Blind Phase III Randomised Controlled Trial Assessing Metformin to Prolong Gestation in Preterm Preeclampsia[NCT06033131] | Phase 3 | 294 participants (Anticipated) | Interventional | 2024-01-22 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for metformin and Proteinuria
| Article | Year |
|---|---|
Effect of Metformin on a Preeclampsia-Like Mouse Model Induced by High-Fat Diet.
Topics: Animals; Blood Pressure; Body Weight; Diet, High-Fat; Disease Models, Animal; Female; Matrix Metallo | 2019 |
Metformin reduces proteinuria in spontaneously hypertensive rats by activating the HIF-2α-VEGF-A pathway.
Topics: AMP-Activated Protein Kinases; Animals; Basic Helix-Loop-Helix Transcription Factors; Blood Pressure | 2021 |
Ameliorative effects of protodioscin on experimental diabetic nephropathy.
Topics: Albuminuria; Animals; Blood Glucose; Blood Urea Nitrogen; Carboxymethylcellulose Sodium; Cholesterol | 2018 |
mTORC1 inhibitors rapamycin and metformin affect cardiovascular markers differentially in ZDF rats.
Topics: Animals; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dis | 2017 |