metformin has been researched along with Premature Birth in 23 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Premature Birth: CHILDBIRTH before 37 weeks of PREGNANCY (259 days from the first day of the mother's last menstrual period, or 245 days after FERTILIZATION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "s-PROK1 was analysed using ELISA at gestational week 19 and related to pregnancy complications, fasting insulin levels, homoeostatic model assessment for insulin resistance (HOMA-IR), testosterone, or androstenedione levels, metformin use, PCOS phenotype and hyperandrogenism." | 9.69 | Maternal serum levels of prokineticin-1 related to pregnancy complications and metformin use in women with polycystic ovary syndrome: a post hoc analysis of two prospective, randomised, placebo-controlled trials. ( Hirschberg, AL; Trouva, A; Ujvari, D; Vanky, E, 2023) |
| "This trial suggests that extended release metformin can prolong gestation in women with preterm pre-eclampsia, although further trials are needed." | 9.41 | Use of metformin to prolong gestation in preterm pre-eclampsia: randomised, double blind, placebo controlled trial. ( Brownfoot, F; Cluver, CA; Decloedt, EH; Hall, DR; Hiscock, R; Kaitu'u-Lino, TJ; Mol, BW; Schell, S; Tong, S; Walker, SP, 2021) |
| "In pregnant women with PCOS, metformin treatment from the late first trimester until delivery might reduce the risk of late miscarriage and preterm birth, but does not prevent gestational diabetes." | 9.30 | Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial. ( Andræ, F; Berg, AH; Bixo, M; Carlsen, SM; Gómez-Real, F; Hestvold, KV; Hirschberg, AL; Hjelle, S; Lønnebotn, M; Løvvik, TS; Mohlin, J; Poromaa, IS; Salvesen, Ø; Steffensen, B; Thorarinsdottir, S; Trouva, A; Underdal, M; Vanky, E; Zabielska, R, 2019) |
| "We systematically assessed the impact of metformin treatment on maternal pregnancy outcomes." | 9.12 | Impact of metformin treatment during pregnancy on maternal outcomes: a systematic review/meta-analysis. ( Aiken, CE; Ozanne, SE; Tarry-Adkins, JL, 2021) |
| "Our results showed that continued use during of metformin, during pregnancy in women with PCOS, had no effect on incidence of fetal abnormalities or fetal birth weight." | 8.93 | Effect of metformin treatment during pregnancy on women with PCOS: a systematic review and meta-analysis. ( Chang, Y; Fang, C; Li, S; Liu, H; Tan, X; Wang, Y; Zhang, X, 2016) |
| "Metformin therapy throughout pregnancy can reduce the RR of miscarriage and premature birth incidence in PCOS patients with no serious side effects." | 8.91 | Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis. ( Du, YK; Feng, L; Hu, D; Lin, XF; Wan, ZH, 2015) |
| "This article is a review of the literature assessing pregnancy outcomes and the effect of metformin treatment among women with polycystic ovary syndrome (PCOS)." | 8.88 | Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview. ( Awwad, JT; Ghazeeri, GS; Nassar, AH; Younes, Z, 2012) |
| "Our aim was to re-evaluate whether metformin may reduce late miscarriage/preterm delivery, pre-eclampsia and gestational diabetes in women with polycystic ovary syndrome (PCOS)." | 8.88 | On the potential of metformin to prevent preterm delivery in women with polycystic ovary syndrome - an epi-analysis. ( Carlsen, SM; DE Zegher, F; Díaz, M; Ibáñez, L; Vanky, E, 2012) |
| "The mean steady-state serum concentration of metformin during pregnancy was 9." | 8.12 | Metformin serum concentrations during pregnancy and post partum - A clinical study in patients with polycystic ovary syndrome. ( Espnes, KA; Gundersen, POM; Hønnås, A; Løvvik, TS; Naavik, A; Skogvoll, E; Spigset, O; Vanky, E; Westin, AA, 2022) |
| "This study aimed to investigate if maternal pregnancy exposure to metformin is associated with increased risk of long-term and short-term adverse outcomes in the child." | 8.12 | Metformin in pregnancy and risk of adverse long-term outcomes: a register-based cohort study. ( Boutmy, E; Brand, KMG; Foch, C; Hakkarainen, KM; Korhonen, P; Morin-Papunen, L; Saarelainen, L; Schlachter, J; Sonajalg, J; Vääräsmäki, M, 2022) |
| "Metformin exposure was associated with a decreased risk of composite hypertensive disorders of pregnancy in patients with pregestational type 2 diabetes." | 8.02 | Metformin Exposure and Risk of Hypertensive Disorders of Pregnancy in Patients with Type 2 Diabetes. ( Adams, JH; Antony, KM; Eddy, A; Hoppe, KK; Iruretagoyena, JI; Racine, JL; Rhoades, JS; Stewart, KS, 2021) |
| "s-PROK1 was analysed using ELISA at gestational week 19 and related to pregnancy complications, fasting insulin levels, homoeostatic model assessment for insulin resistance (HOMA-IR), testosterone, or androstenedione levels, metformin use, PCOS phenotype and hyperandrogenism." | 5.69 | Maternal serum levels of prokineticin-1 related to pregnancy complications and metformin use in women with polycystic ovary syndrome: a post hoc analysis of two prospective, randomised, placebo-controlled trials. ( Hirschberg, AL; Trouva, A; Ujvari, D; Vanky, E, 2023) |
| "This trial suggests that extended release metformin can prolong gestation in women with preterm pre-eclampsia, although further trials are needed." | 5.41 | Use of metformin to prolong gestation in preterm pre-eclampsia: randomised, double blind, placebo controlled trial. ( Brownfoot, F; Cluver, CA; Decloedt, EH; Hall, DR; Hiscock, R; Kaitu'u-Lino, TJ; Mol, BW; Schell, S; Tong, S; Walker, SP, 2021) |
| "In pregnant women with PCOS, metformin treatment from the late first trimester until delivery might reduce the risk of late miscarriage and preterm birth, but does not prevent gestational diabetes." | 5.30 | Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial. ( Andræ, F; Berg, AH; Bixo, M; Carlsen, SM; Gómez-Real, F; Hestvold, KV; Hirschberg, AL; Hjelle, S; Lønnebotn, M; Løvvik, TS; Mohlin, J; Poromaa, IS; Salvesen, Ø; Steffensen, B; Thorarinsdottir, S; Trouva, A; Underdal, M; Vanky, E; Zabielska, R, 2019) |
| "This is a randomized double-blind multi-center clinical trial of insulin plus metformin versus insulin plus placebo for the treatment of type 2 diabetes complicating pregnancy." | 5.27 | Rationale, design, and methods for the Medical Optimization and Management of Pregnancies with Overt Type 2 Diabetes (MOMPOD) study. ( Berry, DC; Boggess, K; de Los Angeles Abreu, M; Dorman, KF; Ivins, AR; Thomas, SD; Young, L, 2018) |
| "We systematically assessed the impact of metformin treatment on maternal pregnancy outcomes." | 5.12 | Impact of metformin treatment during pregnancy on maternal outcomes: a systematic review/meta-analysis. ( Aiken, CE; Ozanne, SE; Tarry-Adkins, JL, 2021) |
| "Our results showed that continued use during of metformin, during pregnancy in women with PCOS, had no effect on incidence of fetal abnormalities or fetal birth weight." | 4.93 | Effect of metformin treatment during pregnancy on women with PCOS: a systematic review and meta-analysis. ( Chang, Y; Fang, C; Li, S; Liu, H; Tan, X; Wang, Y; Zhang, X, 2016) |
| "Metformin therapy throughout pregnancy can reduce the RR of miscarriage and premature birth incidence in PCOS patients with no serious side effects." | 4.91 | Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis. ( Du, YK; Feng, L; Hu, D; Lin, XF; Wan, ZH, 2015) |
| "This article is a review of the literature assessing pregnancy outcomes and the effect of metformin treatment among women with polycystic ovary syndrome (PCOS)." | 4.88 | Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview. ( Awwad, JT; Ghazeeri, GS; Nassar, AH; Younes, Z, 2012) |
| "Our aim was to re-evaluate whether metformin may reduce late miscarriage/preterm delivery, pre-eclampsia and gestational diabetes in women with polycystic ovary syndrome (PCOS)." | 4.88 | On the potential of metformin to prevent preterm delivery in women with polycystic ovary syndrome - an epi-analysis. ( Carlsen, SM; DE Zegher, F; Díaz, M; Ibáñez, L; Vanky, E, 2012) |
| " Metformin treatment reduces the risk of late miscarriage and preterm birth in pregnant women with PCOS." | 4.31 | Immunomodulatory Effects of Metformin Treatment in Pregnant Women With PCOS. ( Giskeødegård, GF; Iversen, AC; Jarmund, AH; Løvvik, TS; Madssen, TS; Ryssdal, M; Steinkjer, B; Stokkeland, LMT; Vanky, E, 2023) |
| "The mean steady-state serum concentration of metformin during pregnancy was 9." | 4.12 | Metformin serum concentrations during pregnancy and post partum - A clinical study in patients with polycystic ovary syndrome. ( Espnes, KA; Gundersen, POM; Hønnås, A; Løvvik, TS; Naavik, A; Skogvoll, E; Spigset, O; Vanky, E; Westin, AA, 2022) |
| "This study aimed to investigate if maternal pregnancy exposure to metformin is associated with increased risk of long-term and short-term adverse outcomes in the child." | 4.12 | Metformin in pregnancy and risk of adverse long-term outcomes: a register-based cohort study. ( Boutmy, E; Brand, KMG; Foch, C; Hakkarainen, KM; Korhonen, P; Morin-Papunen, L; Saarelainen, L; Schlachter, J; Sonajalg, J; Vääräsmäki, M, 2022) |
| "Metformin exposure was associated with a decreased risk of composite hypertensive disorders of pregnancy in patients with pregestational type 2 diabetes." | 4.02 | Metformin Exposure and Risk of Hypertensive Disorders of Pregnancy in Patients with Type 2 Diabetes. ( Adams, JH; Antony, KM; Eddy, A; Hoppe, KK; Iruretagoyena, JI; Racine, JL; Rhoades, JS; Stewart, KS, 2021) |
| "Metformin is widely used for the treatment of gestational diabetes." | 2.82 | Efficacy and safety of metformin compared to insulin in gestational diabetes: a systemic review and meta-analysis of Chinese randomized controlled trials. ( Hu, Y; Li, F; Liu, L; Liu, W; Marx, CM, 2022) |
| "In a south Indian population with gestational diabetes, metformin was associated with better neonatal outcomes than glibenclamide." | 2.80 | Comparison of neonatal outcomes in women with gestational diabetes with moderate hyperglycaemia on metformin or glibenclamide--a randomised controlled trial. ( Abraham, A; Antonisamy, B; Beck, M; Benjamin, SJ; George, A; Jana, AK; Mathews, JE; Sam, D; Thomas, N, 2015) |
| "Metformin is a logical treatment for women with gestational diabetes mellitus, but randomized trials to assess the efficacy and safety of its use for this condition are lacking." | 2.73 | Metformin versus insulin for the treatment of gestational diabetes. ( Battin, MR; Gao, W; Hague, WM; Moore, MP; Rowan, JA, 2008) |
| " The use of antenatal steroids in mothers at risk of preterm delivery complicates management of hyperglycaemia in the immediate antepartum period and requires appropriate dosing adjustments of insulin therapy." | 2.58 | Intra-partum management of women with diabetes. ( Jacob, JJ; Jewel, R, 2018) |
| "The Metformin in Gestational Diabetes (MiG) trial reported similar pregnancy outcomes for metformin versus insulin; however, supplemental insulin was required in 46% of women on metformin." | 1.39 | Fasting blood glucose predicts response to extended-release metformin in gestational diabetes mellitus. ( Campbell, J; Corbould, A; Dennis, A; McBeath, S; Radford, A; Swinton, F, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 10 (43.48) | 24.3611 |
| 2020's | 11 (47.83) | 2.80 |
| Authors | Studies |
|---|---|
| Cluver, CA | 1 |
| Hiscock, R | 1 |
| Decloedt, EH | 1 |
| Hall, DR | 1 |
| Schell, S | 1 |
| Mol, BW | 1 |
| Brownfoot, F | 1 |
| Kaitu'u-Lino, TJ | 1 |
| Walker, SP | 1 |
| Tong, S | 1 |
| Espnes, KA | 1 |
| Hønnås, A | 1 |
| Løvvik, TS | 3 |
| Gundersen, POM | 1 |
| Naavik, A | 1 |
| Skogvoll, E | 1 |
| Westin, AA | 1 |
| Spigset, O | 1 |
| Vanky, E | 5 |
| Brand, KMG | 1 |
| Saarelainen, L | 1 |
| Sonajalg, J | 1 |
| Boutmy, E | 1 |
| Foch, C | 1 |
| Vääräsmäki, M | 1 |
| Morin-Papunen, L | 1 |
| Schlachter, J | 1 |
| Hakkarainen, KM | 1 |
| Korhonen, P | 1 |
| Pan, ML | 1 |
| Chen, LR | 1 |
| Chen, KH | 1 |
| Li, F | 1 |
| Liu, L | 1 |
| Hu, Y | 1 |
| Marx, CM | 1 |
| Liu, W | 1 |
| Lovell, H | 1 |
| Mitchell, A | 1 |
| Ovadia, C | 1 |
| Pitrelli, N | 1 |
| Briley, A | 1 |
| Singh, C | 1 |
| Marschall, HU | 1 |
| Cruickshank, K | 1 |
| Murphy, H | 1 |
| Seed, P | 1 |
| Williamson, C | 1 |
| Ryssdal, M | 1 |
| Stokkeland, LMT | 1 |
| Jarmund, AH | 1 |
| Steinkjer, B | 1 |
| Madssen, TS | 1 |
| Iversen, AC | 1 |
| Giskeødegård, GF | 1 |
| Ujvari, D | 1 |
| Trouva, A | 2 |
| Hirschberg, AL | 2 |
| Tarry-Adkins, JL | 1 |
| Ozanne, SE | 1 |
| Aiken, CE | 1 |
| Racine, JL | 1 |
| Adams, JH | 1 |
| Antony, KM | 1 |
| Hoppe, KK | 1 |
| Iruretagoyena, JI | 1 |
| Stewart, KS | 1 |
| Eddy, A | 1 |
| Rhoades, JS | 1 |
| Sun, X | 1 |
| Tavenier, A | 1 |
| Deng, W | 1 |
| Leishman, E | 1 |
| Bradshaw, HB | 1 |
| Dey, SK | 1 |
| Jewel, R | 1 |
| Jacob, JJ | 1 |
| Berry, DC | 1 |
| Thomas, SD | 1 |
| Dorman, KF | 1 |
| Ivins, AR | 1 |
| de Los Angeles Abreu, M | 1 |
| Young, L | 1 |
| Boggess, K | 1 |
| Egan, AM | 1 |
| Brassill, MJ | 1 |
| Brosnan, E | 1 |
| Carmody, L | 1 |
| Clarke, H | 1 |
| Coogan Kelly, C | 1 |
| Culliney, L | 1 |
| Durkan, M | 1 |
| Fenlon, M | 1 |
| Ferry, P | 1 |
| Hanlon, G | 1 |
| Higgins, T | 1 |
| Hoashi, S | 1 |
| Khamis, A | 1 |
| Kinsley, B | 1 |
| Kinsley, T | 1 |
| Kirwan, B | 1 |
| Liew, A | 1 |
| McGurk, C | 1 |
| McHugh, C | 1 |
| Murphy, MS | 1 |
| Murphy, P | 1 |
| O'Halloran, D | 1 |
| O'Mahony, L | 1 |
| O'Sullivan, E | 1 |
| Nolan, M | 1 |
| Peter, M | 1 |
| Roberts, G | 1 |
| Smyth, A | 1 |
| Todd, M | 1 |
| Tuthill, A | 1 |
| Wan Mahmood, WA | 1 |
| Yousif, O | 1 |
| P Dunne, F | 1 |
| Carlsen, SM | 2 |
| Salvesen, Ø | 1 |
| Steffensen, B | 1 |
| Bixo, M | 1 |
| Gómez-Real, F | 1 |
| Lønnebotn, M | 1 |
| Hestvold, KV | 1 |
| Zabielska, R | 1 |
| Thorarinsdottir, S | 1 |
| Hjelle, S | 1 |
| Berg, AH | 1 |
| Andræ, F | 1 |
| Poromaa, IS | 1 |
| Mohlin, J | 1 |
| Underdal, M | 1 |
| George, A | 1 |
| Mathews, JE | 1 |
| Sam, D | 1 |
| Beck, M | 1 |
| Benjamin, SJ | 1 |
| Abraham, A | 1 |
| Antonisamy, B | 1 |
| Jana, AK | 1 |
| Thomas, N | 1 |
| Feng, L | 1 |
| Lin, XF | 1 |
| Wan, ZH | 1 |
| Hu, D | 1 |
| Du, YK | 1 |
| Tan, X | 1 |
| Li, S | 1 |
| Chang, Y | 1 |
| Fang, C | 1 |
| Liu, H | 1 |
| Zhang, X | 1 |
| Wang, Y | 1 |
| Lundberg, GD | 1 |
| Ghazeeri, GS | 1 |
| Nassar, AH | 1 |
| Younes, Z | 1 |
| Awwad, JT | 1 |
| DE Zegher, F | 1 |
| Díaz, M | 1 |
| Ibáñez, L | 1 |
| Corbould, A | 1 |
| Swinton, F | 1 |
| Radford, A | 1 |
| Campbell, J | 1 |
| McBeath, S | 1 |
| Dennis, A | 1 |
| Rowan, JA | 1 |
| Hague, WM | 1 |
| Gao, W | 1 |
| Battin, MR | 1 |
| Moore, MP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Preeclampsia Intervention 4 - A Triple Blind Phase III Randomised Controlled Trial Assessing Metformin to Prolong Gestation in Preterm Preeclampsia[NCT06033131] | Phase 3 | 294 participants (Anticipated) | Interventional | 2024-01-22 | Not yet recruiting | ||
| Randomised Controlled Trial of Gestational Treatment With Ursodeoxycholic Acid Compared to Metformin to Reduce Effects of Diabetes Mellitus[NCT04407650] | Phase 4 | 158 participants (Anticipated) | Interventional | 2021-07-01 | Recruiting | ||
| Effect of Metformin on Healthy Live Birth After In-vitro Fertilization in Women With Prediabetes Mellitus: a Multicenter Double-blind Placebo Controlled Randomized Trial[NCT06064669] | 988 participants (Anticipated) | Interventional | 2023-10-01 | Not yet recruiting | |||
| Medical Optimization of Management of Type 2 Diabetes Complicating Pregnancy[NCT02932475] | Phase 3 | 831 participants (Actual) | Interventional | 2017-05-25 | Terminated (stopped due to Recommendation by the DSMB that the study be stopped for futility) | ||
| A Prospective, Randomized, Double-blind, Multi-centre Study, Where the Possible Effect of Metformin to Prevent Late Miscarriage and Preterm Delivery is Studied in Women With Polycystic Ovary Syndrome (PCOS)[NCT01587378] | 489 participants (Actual) | Interventional | 2012-10-31 | Completed | |||
| Prevention of Pre-eclampsia Using Metformin: a Randomized Control Trial[NCT04855513] | 414 participants (Anticipated) | Interventional | 2022-03-24 | Not yet recruiting | |||
| A Multi-center, Prospective, Cohort Study to Elucidate the Effects of Metformin Treatment on Steroid Hormones and Social Behavior. Linking Autistic Behaviorial Symptoms to Changes in Steroid Hormone Availability[NCT04930471] | 45 participants (Anticipated) | Observational | 2021-06-30 | Not yet recruiting | |||
| Glyburide and Metformin for the Treatment of Gestational Diabetes Mellitus. A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing These Drugs Either vs Insulin or vs Each Other.[NCT01998113] | 2,509 participants (Actual) | Observational | 2013-03-31 | Completed | |||
| Does Metformin Improve Pregnancy Outcomes (Incidence of LGA (≥90% Birth Weight Centile) Babies, Onset of Maternal GDM, Hypertension, PET, Macrosomia, Shoulder Dystocia, Admission to SCBU) in Obese Non-diabetic Women?[NCT01273584] | Phase 2/Phase 3 | 450 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| Preventing Recurrent Gestational Diabetes Mellitus With Early Metformin Intervention[NCT02394158] | Phase 4 | 112 participants (Anticipated) | Interventional | 2015-01-27 | Recruiting | ||
| Non-inferiority Between Acarbose and Prandial Insulin for the Treatment of Gestational Diabetes Mellitus: a Randomized Multicenter and Prospective Trial. ACARB-GDM Study.[NCT03380546] | Phase 3 | 341 participants (Actual) | Interventional | 2018-07-04 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Neonatal fat mass measured by skin-fold thickness (anthropometrics).The circumference of the upper limb is the circumference of the upper arm, and the circumference of the lower limb equals the mean of the circumferences measured at the midthigh and calf. The volume of the subcutaneous layer of fat covering each cylinder is estimated by multiplying the length times the circumference times the layer of fat estimated by the skinfold measures. The triceps skinfold measure is used as an estimate of the fat thickness of the limbs, and the subscapular skinfold measure approximates the fat thickness of the trunk. Total body fat is estimated by summing the volumes of fat covering each of the cylinders and multiplying by 0.9 (the density of fat). (NCT02932475)
Timeframe: Within 72 hrs of birth
| Intervention | kg (Mean) |
|---|---|
| Maternal Metformin | 0.46 |
| Maternal Placebo | 0.5 |
"Participants with one or more of the following:~capillary blood glucose level of < 30 mg/dL or capillary blood glucose requiring medical treatment, or~Birth trauma (umbilical cord artery pH < 7.0 or shoulder dystocia with brachial plexus injury), or~Hyperbilirubinemia requiring phototherapy, or~Deliver < 37 weeks' gestation, or~Miscarry, are stillborn, experience a neonatal demise, or~Large for gestational age infant (birth weight > 90th percentile for gestational age), or~Small for gestational age infant (birth weight < 10th percentile for gestational age) or low birth weight (< 2500 gm)" (NCT02932475)
Timeframe: An average of 48 hours for term infants and 30 days for preterm infants
| Intervention | Participants (Count of Participants) |
|---|---|
| Metformin | 269 |
| Placebo | 277 |
Adverse maternal outcomes. (NCT02932475)
Timeframe: An average of 48 hours following delivery
| Intervention | Participants (Count of Participants) | ||||
|---|---|---|---|---|---|
| Any adverse event leading to early study agent discontinuation | Any adverse event associated with maternal death | Any adverse event associated with fetal death | Any maternal serious adverse event | Any maternal non-serious adverse event | |
| Metformin | 13 | 2 | 10 | 113 | 149 |
| Placebo | 20 | 1 | 10 | 111 | 157 |
Adverse neonatal outcomes (NCT02932475)
Timeframe: up to 28 days of life
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| Any neonatal serious adverse event | Any neonatal non-serious adverse event | |
| Maternal Metformin | 81 | 157 |
| Maternal Placebo | 105 | 162 |
"Secondary outcome of maternal side effects were defined as:~clinically relevant hypoglycemia defined as capillary blood glucose < 60 or < 80 with symptoms~GI side effects defined as nausea, vomiting, diarrhea" (NCT02932475)
Timeframe: Throughout study until delivery at 40 weeks gestation
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| Clinically relevant hypoglycemia | Gastrointestinal side effects | |
| Metformin | 87 | 182 |
| Placebo | 85 | 171 |
7 reviews available for metformin and Premature Birth
| Article | Year |
|---|---|
Efficacy and safety of metformin compared to insulin in gestational diabetes: a systemic review and meta-analysis of Chinese randomized controlled trials.
Topics: Blood Glucose; Diabetes, Gestational; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Infa | 2022 |
Impact of metformin treatment during pregnancy on maternal outcomes: a systematic review/meta-analysis.
Topics: Birth Weight; Databases, Factual; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Matern | 2021 |
Intra-partum management of women with diabetes.
Topics: Adrenal Cortex Hormones; Blood Glucose; Delivery, Obstetric; Diabetes, Gestational; Disease Manageme | 2018 |
Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis.
Topics: Abortion, Spontaneous; Case-Control Studies; Diabetes, Gestational; Female; Humans; Hypoglycemic Age | 2015 |
Effect of metformin treatment during pregnancy on women with PCOS: a systematic review and meta-analysis.
Topics: Abortion, Spontaneous; Birth Weight; Diabetes, Gestational; Evidence-Based Medicine; Female; Humans; | 2016 |
Effect of metformin treatment during pregnancy on women with PCOS: a systematic review and meta-analysis.
Topics: Abortion, Spontaneous; Birth Weight; Diabetes, Gestational; Evidence-Based Medicine; Female; Humans; | 2016 |
Effect of metformin treatment during pregnancy on women with PCOS: a systematic review and meta-analysis.
Topics: Abortion, Spontaneous; Birth Weight; Diabetes, Gestational; Evidence-Based Medicine; Female; Humans; | 2016 |
Effect of metformin treatment during pregnancy on women with PCOS: a systematic review and meta-analysis.
Topics: Abortion, Spontaneous; Birth Weight; Diabetes, Gestational; Evidence-Based Medicine; Female; Humans; | 2016 |
Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview.
Topics: Abortion, Spontaneous; Diabetes, Gestational; Female; Humans; Hyperandrogenism; Hyperinsulinism; Hyp | 2012 |
On the potential of metformin to prevent preterm delivery in women with polycystic ovary syndrome - an epi-analysis.
Topics: Adolescent; Adult; Female; Humans; Hypoglycemic Agents; Metformin; Middle Aged; Polycystic Ovary Syn | 2012 |
7 trials available for metformin and Premature Birth
| Article | Year |
|---|---|
Use of metformin to prolong gestation in preterm pre-eclampsia: randomised, double blind, placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Double-Blind Method; Endoglin; Female; Gestational Age; Humans; | 2021 |
A multi-centered trial investigating gestational treatment with ursodeoxycholic acid compared to metformin to reduce effects of diabetes mellitus (GUARD): a randomized controlled trial protocol.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glucose; Humans; Infant, Ne | 2022 |
Maternal serum levels of prokineticin-1 related to pregnancy complications and metformin use in women with polycystic ovary syndrome: a post hoc analysis of two prospective, randomised, placebo-controlled trials.
Topics: Female; Gastrointestinal Hormones; Humans; Hyperandrogenism; Hypoglycemic Agents; Infant, Newborn; M | 2023 |
Rationale, design, and methods for the Medical Optimization and Management of Pregnancies with Overt Type 2 Diabetes (MOMPOD) study.
Topics: Adolescent; Adult; Birth Injuries; Diabetes Mellitus, Type 2; Disease Management; Double-Blind Metho | 2018 |
Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Double-B | 2019 |
Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Double-B | 2019 |
Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Double-B | 2019 |
Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial.
Topics: Abortion, Spontaneous; Adolescent; Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Double-B | 2019 |
Comparison of neonatal outcomes in women with gestational diabetes with moderate hyperglycaemia on metformin or glibenclamide--a randomised controlled trial.
Topics: Adult; Birth Injuries; Birth Weight; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Hum | 2015 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Metformin versus insulin for the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
9 other studies available for metformin and Premature Birth
| Article | Year |
|---|---|
Metformin serum concentrations during pregnancy and post partum - A clinical study in patients with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Female; Humans; Hypoglycemic Agents; Infant, Newborn; Metformin; Polycystic O | 2022 |
Metformin in pregnancy and risk of adverse long-term outcomes: a register-based cohort study.
Topics: Child; Cohort Studies; Female; Humans; Hypoglycemic Agents; Infant, Newborn; Insulin; Metformin; Pre | 2022 |
Prepregnancy Polycystic Ovary Syndrome as a Risk Factor of Subsequent Preterm Labor: A National Population-Based Cohort Study.
Topics: Cohort Studies; Female; Humans; Infant, Newborn; Metformin; Polycystic Ovary Syndrome; Pregnancy; Pr | 2022 |
Immunomodulatory Effects of Metformin Treatment in Pregnant Women With PCOS.
Topics: Abortion, Spontaneous; Cytokines; Female; Humans; Hypoglycemic Agents; Infant, Newborn; Metformin; P | 2023 |
Metformin Exposure and Risk of Hypertensive Disorders of Pregnancy in Patients with Type 2 Diabetes.
Topics: Adult; Birth Weight; Diabetes Mellitus, Type 2; Female; Fetal Growth Retardation; Humans; Hypertensi | 2021 |
Metformin attenuates susceptibility to inflammation-induced preterm birth in mice with higher endocannabinoid levels.
Topics: Amidohydrolases; Animals; Decidua; Endocannabinoids; Female; Hypoglycemic Agents; Inflammation; Lipo | 2018 |
An Irish National Diabetes in Pregnancy Audit: aiming for best outcomes for women with diabetes.
Topics: Abortion, Spontaneous; Adult; Aspirin; Cesarean Section; Clinical Audit; Delivery of Health Care; De | 2020 |
Metformin Trumps insulin in the treatment of gestational diabetes.
Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem | 2008 |
Fasting blood glucose predicts response to extended-release metformin in gestational diabetes mellitus.
Topics: Adult; Blood Glucose; Delayed-Action Preparations; Diabetes, Gestational; Female; Glucose Tolerance | 2013 |