metformin has been researched along with Peritonitis in 2 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Peritonitis: INFLAMMATION of the PERITONEUM lining the ABDOMINAL CAVITY as the result of infectious, autoimmune, or chemical processes. Primary peritonitis is due to infection of the PERITONEAL CAVITY via hematogenous or lymphatic spread and without intra-abdominal source. Secondary peritonitis arises from the ABDOMINAL CAVITY itself through RUPTURE or ABSCESS of intra-abdominal organs.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In addition to their effects on chemotaxis, treatment of neutrophils with metformin or aminoimidazole carboxamide ribonucleotide (AICAR) improved phagocytosis and bacterial killing, including more efficient eradication of bacteria in a mouse model of peritonitis-induced sepsis." | 3.79 | Activation of AMPK enhances neutrophil chemotaxis and bacterial killing. ( Abraham, E; Deshane, J; Gao, Y; Jiang, S; Park, DW; Stigler, WS; Tadie, JM; Zmijewski, JW, 2013) |
| "Mast cells are major effectors of allergy and asthma, and can be activated by the alarmin IL-33, which is linked to allergic disease." | 1.48 | Inhibiting Glycolysis and ATP Production Attenuates IL-33-Mediated Mast Cell Function and Peritonitis. ( Baldwin, EA; Barnstein, BO; Caslin, HL; Haque, T; Pondicherry, N; Ryan, JJ; Taruselli, MT, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caslin, HL | 1 |
| Taruselli, MT | 1 |
| Haque, T | 1 |
| Pondicherry, N | 1 |
| Baldwin, EA | 1 |
| Barnstein, BO | 1 |
| Ryan, JJ | 1 |
| Park, DW | 1 |
| Jiang, S | 1 |
| Tadie, JM | 1 |
| Stigler, WS | 1 |
| Gao, Y | 1 |
| Deshane, J | 1 |
| Abraham, E | 1 |
| Zmijewski, JW | 1 |
2 other studies available for metformin and Peritonitis
| Article | Year |
|---|---|
Inhibiting Glycolysis and ATP Production Attenuates IL-33-Mediated Mast Cell Function and Peritonitis.
Topics: Adenosine Triphosphate; Animals; Antimetabolites; Cells, Cultured; Deoxyglucose; Disease Models, Ani | 2018 |
Activation of AMPK enhances neutrophil chemotaxis and bacterial killing.
Topics: Actins; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Bacteremia; Chemotaxis, | 2013 |