metformin has been researched along with Peripheral Nerve Diseases in 18 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin may be a promising drug in protecting colorectal cancer patients against oxaliplatin-induced chronic peripheral sensory neuropathy." | 9.27 | Role of metformin in oxaliplatin-induced peripheral neuropathy in patients with stage III colorectal cancer: randomized, controlled study. ( El-Fatatry, BM; Hussien, FZ; Ibrahim, OM; Mostafa, TM, 2018) |
| "Metformin may be a promising drug in protecting colorectal cancer patients against oxaliplatin-induced chronic peripheral sensory neuropathy." | 5.27 | Role of metformin in oxaliplatin-induced peripheral neuropathy in patients with stage III colorectal cancer: randomized, controlled study. ( El-Fatatry, BM; Hussien, FZ; Ibrahim, OM; Mostafa, TM, 2018) |
| "Metformin treatment did not affect VDT group difference - 0." | 2.94 | Metformin may adversely affect orthostatic blood pressure recovery in patients with type 2 diabetes: substudy from the placebo-controlled Copenhagen Insulin and Metformin Therapy (CIMT) trial. ( Almdal, T; Carstensen, B; Gluud, C; Hansen, CS; Hedetoft, C; Hemmingsen, B; Jørgensen, ME; Krarup, T; Lund, SS; Lundby-Christiansen, L; Madsbad, S; Sneppen, SB; Tarnow, L; Thorsteinsson, B; Wiinberg, N, 2020) |
| "High daily dosage (≥1500 mg/day) played an important role in metformin-associated vitamin B12 deficiency while not contributing to the risk of PN." | 1.91 | The effects of daily dose and treatment duration of metformin on the prevalence of vitamin B12 deficiency and peripheral neuropathy in Chinese patients with type 2 diabetes mellitus: A multicenter cross-sectional study. ( Bi, Y; Chen, S; Gao, L; Ji, L; Lei, M; Liu, F; Liu, X; Lu, Y; Ran, X; Shen, X; Su, Q; Wang, Y; Zhao, D, 2023) |
| "Metformin-treated diabetics (MTD) showed a decrease in cobalamin, a rise in homocysteine, and methylmalonic acid, leading to accentuated diabetic peripheral neuropathy (DPN)." | 1.62 | The relationship between exacerbated diabetic peripheral neuropathy and metformin treatment in type 2 diabetes mellitus. ( El-Sherif, M; Esmael, A; Hashem, MM; Nassar, AK, 2021) |
| "Metformin is an anti-diabetic drug that is described to negatively modulate painful diabetic neuropathy." | 1.51 | Metformin reduces c-Fos and ATF3 expression in the dorsal root ganglia and protects against oxaliplatin-induced peripheral sensory neuropathy in mice. ( Alencar, NMN; Barbosa, JS; Freitas Alves, BW; Lima-Júnior, RCP; Pereira, AC; Pereira, AF; Pereira, LMS; Pinto, FMM; Pontes, RB; Silva, CMP; Silva, KO; Vale, ML, 2019) |
| "To compare the prevalence of vitamin B12 deficiency and peripheral neuropathy between two groups of type 2 diabetes mellitus (T2DM) patients treated with or without metformin, and to determine factors associated with vitamin B12 deficiency therapy and dietary intake of vitamin B12." | 1.48 | The association of metformin use with vitamin B12 deficiency and peripheral neuropathy in Saudi individuals with type 2 diabetes mellitus. ( Abdelhay, O; Abuhaimed, SN; Al-Asmari, AK; AlHarbi, NG; Alharbi, TJ; Alkhashan, HI; AlRasheed, AN; Bin Rsheed, AM; Mohammed, N; Tourkmani, AM, 2018) |
| "The prevalence of vitamin B12 deficiency (defined by concentrations <150 pmol/L) was determined." | 1.43 | Vitamin B12 deficiency in metformin-treated type-2 diabetes patients, prevalence and association with peripheral neuropathy. ( Ahmed, MA; Muntingh, G; Rheeder, P, 2016) |
| "Metformin-treated patients had depressed Cbl levels and elevated fasting MMA and Hcy levels." | 1.36 | Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy. ( Toth, C; Wile, DJ, 2010) |
| "Metformin has been available in the United States for approximately fifteen years." | 1.36 | Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy. ( Bell, DS, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 10 (55.56) | 24.3611 |
| 2020's | 7 (38.89) | 2.80 |
| Authors | Studies |
|---|---|
| Bell, DSH | 1 |
| Xu, N | 1 |
| Qiu, ZQ | 1 |
| Zeng, XJ | 1 |
| Li, BQ | 1 |
| Zhang, XM | 1 |
| Huang, X | 1 |
| Pratama, S | 1 |
| Lauren, BC | 1 |
| Wisnu, W | 1 |
| Gao, L | 1 |
| Ran, X | 1 |
| Liu, X | 1 |
| Shen, X | 1 |
| Chen, S | 1 |
| Liu, F | 1 |
| Zhao, D | 1 |
| Bi, Y | 1 |
| Su, Q | 1 |
| Lu, Y | 1 |
| Lei, M | 1 |
| Wang, Y | 1 |
| Ji, L | 2 |
| Bhattacharyya, A | 1 |
| Das, SL | 1 |
| Basu, DA | 1 |
| Hansen, CS | 1 |
| Lundby-Christiansen, L | 1 |
| Tarnow, L | 1 |
| Gluud, C | 1 |
| Hedetoft, C | 1 |
| Thorsteinsson, B | 1 |
| Hemmingsen, B | 1 |
| Wiinberg, N | 1 |
| Sneppen, SB | 1 |
| Lund, SS | 1 |
| Krarup, T | 1 |
| Madsbad, S | 1 |
| Almdal, T | 1 |
| Carstensen, B | 1 |
| Jørgensen, ME | 1 |
| Hashem, MM | 1 |
| Esmael, A | 1 |
| Nassar, AK | 1 |
| El-Sherif, M | 1 |
| El-Fatatry, BM | 1 |
| Ibrahim, OM | 1 |
| Hussien, FZ | 1 |
| Mostafa, TM | 1 |
| Alharbi, TJ | 1 |
| Tourkmani, AM | 1 |
| Abdelhay, O | 1 |
| Alkhashan, HI | 1 |
| Al-Asmari, AK | 1 |
| Bin Rsheed, AM | 1 |
| Abuhaimed, SN | 1 |
| Mohammed, N | 1 |
| AlRasheed, AN | 1 |
| AlHarbi, NG | 1 |
| Yang, W | 1 |
| Cai, X | 1 |
| Wu, H | 1 |
| Pereira, AF | 1 |
| Pereira, LMS | 1 |
| Silva, CMP | 1 |
| Freitas Alves, BW | 1 |
| Barbosa, JS | 1 |
| Pinto, FMM | 1 |
| Pereira, AC | 1 |
| Silva, KO | 1 |
| Pontes, RB | 1 |
| Alencar, NMN | 1 |
| Lima-Júnior, RCP | 1 |
| Vale, ML | 1 |
| Mao-Ying, QL | 1 |
| Kavelaars, A | 1 |
| Krukowski, K | 1 |
| Huo, XJ | 1 |
| Zhou, W | 1 |
| Price, TJ | 1 |
| Cleeland, C | 1 |
| Heijnen, CJ | 1 |
| Okanović, A | 1 |
| Prnjavorac, B | 1 |
| Jusufović, E | 1 |
| Sejdinović, R | 1 |
| Ahmed, MA | 1 |
| Muntingh, G | 1 |
| Rheeder, P | 1 |
| Wile, DJ | 1 |
| Toth, C | 1 |
| Bell, DS | 1 |
| Moore, E | 1 |
| Mander, A | 1 |
| Watters, D | 1 |
| Zhang, YF | 1 |
| Ning, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Metformin Versus Placebo, Including Three Insulin-Analogue Regimens With Variating Postprandial Glucose Regulation, on CIMT in T2DM Patients - A Randomized, Multicenter Trial[NCT00657943] | Phase 4 | 415 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
| Drug Repurposing Using Metformin for Improving the Therapeutic Outcome in Multiple Sclerosis Patients[NCT05298670] | Phase 2 | 80 participants (Anticipated) | Interventional | 2022-02-01 | Recruiting | ||
| Electro-acupuncture for the Prevention and Treatment of Oxaliplatin-induced Neurotoxicity in Colorectal Cancer Patients: a Prospective, Randomized, Sham-controlled, Double-blinded and Multicenter Study[NCT05798884] | 150 participants (Anticipated) | Interventional | 2023-05-31 | Not yet recruiting | |||
| Drug Repurposing for the Prevention of Chemotherapy-induced Peripheral Neuropathy (CIPN)[NCT04780854] | Phase 2 | 68 participants (Anticipated) | Interventional | 2020-11-03 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for metformin and Peripheral Nerve Diseases
| Article | Year |
|---|---|
Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes.
Topics: Aged; Calcium; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Peripheral Nervous | 2022 |
The efficacy of vitamin B
Topics: Diabetes Mellitus, Type 2; Dietary Supplements; Homocysteine; Humans; Hypoglycemic Agents; Metformin | 2022 |
Associations between metformin use and vitamin B
Topics: Anemia; Case-Control Studies; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Per | 2019 |
Mecobalamin.
Topics: Aged; Alprostadil; Animals; Cobamides; Coenzymes; Diabetic Neuropathies; Drug Administration Routes; | 2008 |
2 trials available for metformin and Peripheral Nerve Diseases
| Article | Year |
|---|---|
Metformin may adversely affect orthostatic blood pressure recovery in patients with type 2 diabetes: substudy from the placebo-controlled Copenhagen Insulin and Metformin Therapy (CIMT) trial.
Topics: Aged; Autonomic Nervous System Diseases; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Neuropa | 2020 |
Role of metformin in oxaliplatin-induced peripheral neuropathy in patients with stage III colorectal cancer: randomized, controlled study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Egypt; Fluorouracil; Humans; L | 2018 |
Role of metformin in oxaliplatin-induced peripheral neuropathy in patients with stage III colorectal cancer: randomized, controlled study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Egypt; Fluorouracil; Humans; L | 2018 |
Role of metformin in oxaliplatin-induced peripheral neuropathy in patients with stage III colorectal cancer: randomized, controlled study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Egypt; Fluorouracil; Humans; L | 2018 |
Role of metformin in oxaliplatin-induced peripheral neuropathy in patients with stage III colorectal cancer: randomized, controlled study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Egypt; Fluorouracil; Humans; L | 2018 |
12 other studies available for metformin and Peripheral Nerve Diseases
| Article | Year |
|---|---|
[Peripheral neuropathy caused by vitamin B
Topics: Glycogen Storage Disease Type I; Humans; Metformin; Peripheral Nervous System Diseases; Vitamin B 12 | 2022 |
The effects of daily dose and treatment duration of metformin on the prevalence of vitamin B12 deficiency and peripheral neuropathy in Chinese patients with type 2 diabetes mellitus: A multicenter cross-sectional study.
Topics: Cross-Sectional Studies; Diabetes Mellitus, Type 2; Duration of Therapy; East Asian People; Humans; | 2023 |
Evaluation of Risk Factors of Peripheral Neuropathy in Type 2 Diabetes Mellitus Patients with Special Reference to Vitamin B12 Defi ciency.
Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Peripheral Nervous System Disease | 2020 |
The relationship between exacerbated diabetic peripheral neuropathy and metformin treatment in type 2 diabetes mellitus.
Topics: Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Homocysteine; Humans; Male; Metformin; Met | 2021 |
The association of metformin use with vitamin B12 deficiency and peripheral neuropathy in Saudi individuals with type 2 diabetes mellitus.
Topics: Diabetes Mellitus, Type 2; Diet; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; | 2018 |
Metformin reduces c-Fos and ATF3 expression in the dorsal root ganglia and protects against oxaliplatin-induced peripheral sensory neuropathy in mice.
Topics: Activating Transcription Factor 3; Animals; Antineoplastic Agents; Ganglia, Spinal; Gene Expression; | 2019 |
The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model.
Topics: Animals; Cisplatin; Disease Models, Animal; Hyperalgesia; Hypoglycemic Agents; Metformin; Mice, Inbr | 2014 |
Alpha-lipoic acid reduces body weight and regulates triglycerides in obese patients with diabetes mellitus.
Topics: Body Weight; Cholesterol; Diabetes Mellitus, Type 2; Female; Humans; Male; Metformin; Middle Aged; O | 2015 |
Vitamin B12 deficiency in metformin-treated type-2 diabetes patients, prevalence and association with peripheral neuropathy.
Topics: Aged; Black People; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic | 2016 |
Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy.
Topics: Aged; Case-Control Studies; Chromatography, High Pressure Liquid; Diabetic Neuropathies; Electrophys | 2010 |
Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy.
Topics: Aged; Humans; Hypoglycemic Agents; Male; Metformin; Peripheral Nervous System Diseases; Vitamin B 12 | 2010 |
More adverse neurological consequences of metformin-induced vitamin B12 deficiency.
Topics: Humans; Hypoglycemic Agents; Male; Metformin; Peripheral Nervous System Diseases; Vitamin B 12 Defic | 2011 |