metformin has been researched along with Periodontitis in 12 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Periodontitis: Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
Excerpt | Relevance | Reference |
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"We found that metformin treatment can robustly ameliorate periodontal infection and tissue destruction and reduce blood glucose and serum IL-1β levels in mice with diabetic periodontitis." | 7.91 | Metformin ameliorates experimental diabetic periodontitis independently of mammalian target of rapamycin (mTOR) inhibition by reducing NIMA-related kinase 7 (Nek7) expression. ( Ding, Y; Ji, N; Wang, Q; Xia, S; Zhang, P; Zhou, X, 2019) |
"The aim of this study was to develop a chitosan-metformin based intrapocket dental film (CMIDF) for applications in the treatment of periodontitis and alveolar bone loss in an rat model of periodontitis." | 7.88 | Development and evaluation of novel biodegradable chitosan based metformin intrapocket dental film for the management of periodontitis and alveolar bone loss in a rat model. ( Karasik, D; Khajuria, DK; Patil, ON; Razdan, R, 2018) |
"To evaluate the effects of metformin (Met) on inflammation, oxidative stress, and bone loss in a rat model of ligature-induced periodontitis." | 7.85 | Effects of metformin on inflammation, oxidative stress, and bone loss in a rat model of periodontitis. ( Araújo Júnior, RF; Araújo, AA; Araújo, LS; Brito, GAC; Guedes, PMM; Hiyari, S; Leitão, RFC; Medeiros, CACX; Pereira, ASBF; Pirih, FQ, 2017) |
"In ligature-induced periodontitis, the metformin treatment of rats induced a significant reduction in alveolar bone loss compared to vehicle-treated rats." | 7.76 | The effect of metformin on alveolar bone in ligature-induced periodontitis in rats: a pilot study. ( Bak, EJ; Cha, JH; Choi, SH; Kim, M; Kim, S; Kim, SW; Park, HG; Yoo, YJ, 2010) |
"Periodontitis is a progressive infectious inflammatory disease, which leads to alveolar bone resorption and loss of periodontal attachment." | 5.62 | Metformin-loaded β-TCP/CTS/SBA-15 composite scaffolds promote alveolar bone regeneration in a rat model of periodontitis. ( Li, C; Tan, W; Wu, K; Xiao, L; Xu, W; Zeng, X, 2021) |
"Metformin treatment significantly suppressed the inflammatory responses induced by P." | 5.56 | The anti-periodontitis action of metformin via targeting NLRP3 inflammasome. ( Chen, B; Chen, J; Chen, X; Gao, J; Jiang, Y; Li, J; Tan, Y, 2020) |
"This study evaluated the influence of type 2 diabetes mellitus on bone loss, bone repair and cytokine production in hyperglycemic rats, treated or not with metformin." | 5.56 | Impact of hyperglycemia and treatment with metformin on ligature-induced bone loss, bone repair and expression of bone metabolism transcription factors. ( Azarias, JS; Bastos, MF; Garcia, RP; Malta, FS; Miranda, TS; Ribeiro, GKDR; Shibli, JA, 2020) |
"We found that metformin treatment can robustly ameliorate periodontal infection and tissue destruction and reduce blood glucose and serum IL-1β levels in mice with diabetic periodontitis." | 3.91 | Metformin ameliorates experimental diabetic periodontitis independently of mammalian target of rapamycin (mTOR) inhibition by reducing NIMA-related kinase 7 (Nek7) expression. ( Ding, Y; Ji, N; Wang, Q; Xia, S; Zhang, P; Zhou, X, 2019) |
"The aim of this study was to develop a chitosan-metformin based intrapocket dental film (CMIDF) for applications in the treatment of periodontitis and alveolar bone loss in an rat model of periodontitis." | 3.88 | Development and evaluation of novel biodegradable chitosan based metformin intrapocket dental film for the management of periodontitis and alveolar bone loss in a rat model. ( Karasik, D; Khajuria, DK; Patil, ON; Razdan, R, 2018) |
"To evaluate the effects of metformin (Met) on inflammation, oxidative stress, and bone loss in a rat model of ligature-induced periodontitis." | 3.85 | Effects of metformin on inflammation, oxidative stress, and bone loss in a rat model of periodontitis. ( Araújo Júnior, RF; Araújo, AA; Araújo, LS; Brito, GAC; Guedes, PMM; Hiyari, S; Leitão, RFC; Medeiros, CACX; Pereira, ASBF; Pirih, FQ, 2017) |
" Recent studies suggested that the anti-diabetic drug metformin hydrochloride (MF) has an osteogenic effect and is beneficial for the management of periodontitis." | 3.85 | Thiolated alginate-based multiple layer mucoadhesive films of metformin forintra-pocket local delivery: in vitro characterization and clinical assessment. ( Farid, RM; Issa, DA; Kassem, AA; Kotry, GS, 2017) |
"In ligature-induced periodontitis, the metformin treatment of rats induced a significant reduction in alveolar bone loss compared to vehicle-treated rats." | 3.76 | The effect of metformin on alveolar bone in ligature-induced periodontitis in rats: a pilot study. ( Bak, EJ; Cha, JH; Choi, SH; Kim, M; Kim, S; Kim, SW; Park, HG; Yoo, YJ, 2010) |
"Periodontitis is a progressive infectious inflammatory disease, which leads to alveolar bone resorption and loss of periodontal attachment." | 1.62 | Metformin-loaded β-TCP/CTS/SBA-15 composite scaffolds promote alveolar bone regeneration in a rat model of periodontitis. ( Li, C; Tan, W; Wu, K; Xiao, L; Xu, W; Zeng, X, 2021) |
"Metformin treatment significantly suppressed the inflammatory responses induced by P." | 1.56 | The anti-periodontitis action of metformin via targeting NLRP3 inflammasome. ( Chen, B; Chen, J; Chen, X; Gao, J; Jiang, Y; Li, J; Tan, Y, 2020) |
"This study evaluated the influence of type 2 diabetes mellitus on bone loss, bone repair and cytokine production in hyperglycemic rats, treated or not with metformin." | 1.56 | Impact of hyperglycemia and treatment with metformin on ligature-induced bone loss, bone repair and expression of bone metabolism transcription factors. ( Azarias, JS; Bastos, MF; Garcia, RP; Malta, FS; Miranda, TS; Ribeiro, GKDR; Shibli, JA, 2020) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 6 (50.00) | 24.3611 |
2020's | 6 (50.00) | 2.80 |
Authors | Studies |
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Xu, W | 1 |
Tan, W | 1 |
Li, C | 2 |
Wu, K | 2 |
Zeng, X | 1 |
Xiao, L | 1 |
Tan, Y | 1 |
Chen, J | 2 |
Jiang, Y | 2 |
Chen, X | 2 |
Li, J | 8 |
Chen, B | 2 |
Gao, J | 2 |
Zhou, X | 4 |
Wang, Q | 6 |
Nie, L | 1 |
Zhang, P | 3 |
Zhao, P | 1 |
Yuan, Q | 1 |
Ji, N | 2 |
Ding, Y | 2 |
Malta, FS | 1 |
Garcia, RP | 1 |
Azarias, JS | 1 |
Ribeiro, GKDR | 1 |
Miranda, TS | 1 |
Shibli, JA | 1 |
Bastos, MF | 1 |
Nguépy Keubo, FR | 1 |
Mboua, PC | 1 |
Djifack Tadongfack, T | 1 |
Fokouong Tchoffo, E | 1 |
Tasson Tatang, C | 1 |
Ide Zeuna, J | 1 |
Noupoue, EM | 1 |
Tsoplifack, CB | 1 |
Folefack, GO | 1 |
Kettani, M | 1 |
Bandelier, P | 1 |
Huo, J | 1 |
Li, H | 4 |
Yu, D | 1 |
Arulsamy, N | 1 |
AlAbbad, S | 1 |
Sardot, T | 1 |
Lekashvili, O | 1 |
Decato, D | 1 |
Lelj, F | 1 |
Alexander Ross, JB | 1 |
Rosenberg, E | 1 |
Nazir, H | 1 |
Muthuswamy, N | 1 |
Louis, C | 1 |
Jose, S | 1 |
Prakash, J | 1 |
Buan, MEM | 1 |
Flox, C | 1 |
Chavan, S | 1 |
Shi, X | 1 |
Kauranen, P | 1 |
Kallio, T | 1 |
Maia, G | 1 |
Tammeveski, K | 1 |
Lymperopoulos, N | 1 |
Carcadea, E | 1 |
Veziroglu, E | 1 |
Iranzo, A | 1 |
M Kannan, A | 1 |
Arunamata, A | 1 |
Tacy, TA | 1 |
Kache, S | 1 |
Mainwaring, RD | 1 |
Ma, M | 1 |
Maeda, K | 1 |
Punn, R | 1 |
Noguchi, S | 1 |
Hahn, S | 3 |
Iwasa, Y | 3 |
Ling, J | 2 |
Voccio, JP | 2 |
Kim, Y | 3 |
Song, J | 3 |
Bascuñán, J | 2 |
Chu, Y | 1 |
Tomita, M | 1 |
Cazorla, M | 1 |
Herrera, E | 1 |
Palomeque, E | 1 |
Saud, N | 1 |
Hoplock, LB | 1 |
Lobchuk, MM | 1 |
Lemoine, J | 1 |
Li, X | 10 |
Henson, MA | 1 |
Unsihuay, D | 1 |
Qiu, J | 1 |
Swaroop, S | 1 |
Nagornov, KO | 1 |
Kozhinov, AN | 1 |
Tsybin, YO | 1 |
Kuang, S | 1 |
Laskin, J | 1 |
Zin, NNINM | 1 |
Mohamad, MN | 1 |
Roslan, K | 1 |
Abdul Wafi, S | 1 |
Abdul Moin, NI | 1 |
Alias, A | 1 |
Zakaria, Y | 1 |
Abu-Bakar, N | 1 |
Naveed, A | 1 |
Jilani, K | 1 |
Siddique, AB | 1 |
Akbar, M | 1 |
Riaz, M | 1 |
Mushtaq, Z | 1 |
Sikandar, M | 1 |
Ilyas, S | 1 |
Bibi, I | 1 |
Asghar, A | 1 |
Rasool, G | 1 |
Irfan, M | 1 |
Li, XY | 1 |
Zhao, S | 1 |
Fan, XH | 1 |
Chen, KP | 1 |
Hua, W | 1 |
Liu, ZM | 1 |
Xue, XD | 1 |
Zhou, B | 1 |
Zhang, S | 2 |
Xing, YL | 1 |
Chen, MA | 1 |
Sun, Y | 1 |
Neradilek, MB | 1 |
Wu, XT | 1 |
Zhang, D | 2 |
Huang, W | 1 |
Cui, Y | 1 |
Yang, QQ | 1 |
Li, HW | 1 |
Zhao, XQ | 1 |
Hossein Rashidi, B | 1 |
Tarafdari, A | 1 |
Ghazimirsaeed, ST | 1 |
Shahrokh Tehraninezhad, E | 1 |
Keikha, F | 1 |
Eslami, B | 1 |
Ghazimirsaeed, SM | 1 |
Jafarabadi, M | 1 |
Silvani, Y | 1 |
Lovita, AND | 1 |
Maharani, A | 1 |
Wiyasa, IWA | 1 |
Sujuti, H | 1 |
Ratnawati, R | 1 |
Raras, TYM | 1 |
Lemin, AS | 1 |
Rahman, MM | 1 |
Pangarah, CA | 1 |
Kiyu, A | 1 |
Zeng, C | 2 |
Du, H | 1 |
Lin, D | 1 |
Jalan, D | 1 |
Rubagumya, F | 1 |
Hopman, WM | 1 |
Vanderpuye, V | 1 |
Lopes, G | 1 |
Seruga, B | 1 |
Booth, CM | 1 |
Berry, S | 1 |
Hammad, N | 1 |
Sajo, EA | 1 |
Okunade, KS | 1 |
Olorunfemi, G | 1 |
Rabiu, KA | 1 |
Anorlu, RI | 1 |
Xu, C | 2 |
Xiang, Y | 1 |
Xu, X | 1 |
Zhou, L | 2 |
Dong, X | 1 |
Tang, S | 1 |
Gao, XC | 1 |
Wei, CH | 1 |
Zhang, RG | 1 |
Cai, Q | 1 |
He, Y | 1 |
Tong, F | 1 |
Dong, JH | 1 |
Wu, G | 1 |
Dong, XR | 1 |
Tang, X | 1 |
Tao, F | 1 |
Xiang, W | 1 |
Zhao, Y | 2 |
Jin, L | 1 |
Tao, H | 1 |
Lei, Y | 1 |
Gan, H | 1 |
Huang, Y | 1 |
Chen, Y | 3 |
Chen, L | 3 |
Shan, A | 1 |
Zhao, H | 2 |
Wu, M | 2 |
Ma, Q | 1 |
Wang, J | 4 |
Zhang, E | 1 |
Zhang, J | 3 |
Li, Y | 5 |
Xue, F | 1 |
Deng, L | 1 |
Liu, L | 2 |
Yan, Z | 2 |
Wang, Y | 2 |
Meng, J | 1 |
Chen, G | 2 |
Anastassiadou, M | 1 |
Bernasconi, G | 1 |
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Carrasco Cabrera, L | 1 |
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Li, P | 1 |
Jiao, Q | 1 |
Meng, P | 1 |
Wang, F | 2 |
Wang, YS | 1 |
Wang, C | 3 |
Wang, W | 1 |
Wang, S | 2 |
Hou, J | 1 |
Zhang, A | 1 |
Lv, B | 1 |
Gao, C | 1 |
Pang, D | 1 |
Lu, K | 1 |
Ahmad, NH | 1 |
Wang, L | 1 |
Zhu, J | 2 |
Zhang, L | 2 |
Zhuang, T | 1 |
Tu, J | 1 |
Zhao, Z | 1 |
Qu, Y | 1 |
Yao, H | 1 |
Wang, X | 5 |
Lee, DF | 1 |
Shen, J | 3 |
Wen, L | 1 |
Huang, G | 2 |
Xie, X | 1 |
Zhao, Q | 1 |
Hu, W | 1 |
Zhang, Y | 4 |
Wu, X | 1 |
Lu, J | 2 |
Li, M | 2 |
Li, W | 2 |
Wu, W | 1 |
Du, F | 1 |
Ji, H | 1 |
Yang, X | 2 |
Xu, Z | 1 |
Wan, L | 1 |
Wen, Q | 1 |
Cho, CH | 1 |
Zou, C | 1 |
Xiao, Z | 1 |
Liao, J | 1 |
Su, X | 1 |
Bi, Z | 1 |
Su, Q | 1 |
Huang, H | 1 |
Wei, Y | 2 |
Gao, Y | 2 |
Na, KJ | 1 |
Choi, H | 1 |
Oh, HR | 1 |
Kim, YH | 1 |
Lee, SB | 1 |
Jung, YJ | 1 |
Koh, J | 1 |
Park, S | 1 |
Lee, HJ | 1 |
Jeon, YK | 1 |
Chung, DH | 1 |
Paeng, JC | 1 |
Park, IK | 1 |
Kang, CH | 1 |
Cheon, GJ | 1 |
Kang, KW | 1 |
Lee, DS | 1 |
Kim, YT | 1 |
Pajuelo-Lozano, N | 1 |
Alcalá, S | 1 |
Sainz, B | 1 |
Perona, R | 1 |
Sanchez-Perez, I | 1 |
Logotheti, S | 1 |
Marquardt, S | 1 |
Gupta, SK | 1 |
Richter, C | 1 |
Edelhäuser, BAH | 1 |
Engelmann, D | 1 |
Brenmoehl, J | 1 |
Söhnchen, C | 1 |
Murr, N | 1 |
Alpers, M | 1 |
Singh, KP | 1 |
Wolkenhauer, O | 1 |
Heckl, D | 1 |
Spitschak, A | 1 |
Pützer, BM | 1 |
Liao, Y | 1 |
Cheng, J | 1 |
Kong, X | 1 |
Li, S | 1 |
Zhang, M | 4 |
Zhang, H | 1 |
Yang, T | 2 |
Dong, Y | 1 |
Xu, Y | 1 |
Yuan, Z | 1 |
Cao, J | 1 |
Zheng, Y | 1 |
Luo, Z | 1 |
Mei, Z | 1 |
Yao, Y | 1 |
Liu, Z | 2 |
Liang, C | 1 |
Yang, H | 1 |
Song, Y | 1 |
Yu, K | 1 |
Zhu, C | 1 |
Huang, Z | 1 |
Qian, J | 1 |
Ge, J | 1 |
Hu, J | 2 |
Wang, H | 2 |
Liu, Y | 4 |
Mi, Y | 1 |
Kong, H | 1 |
Xi, D | 1 |
Yan, W | 1 |
Luo, X | 1 |
Ning, Q | 1 |
Chang, X | 2 |
Zhang, T | 2 |
Rathore, MG | 1 |
Reddy, K | 1 |
Chen, H | 1 |
Shin, SH | 1 |
Ma, WY | 1 |
Bode, AM | 1 |
Dong, Z | 1 |
Mu, W | 1 |
Liu, C | 3 |
Gao, F | 1 |
Qi, Y | 1 |
Lu, H | 1 |
Zhang, X | 4 |
Cai, X | 1 |
Ji, RY | 1 |
Hou, Y | 3 |
Tian, J | 2 |
Shi, Y | 1 |
Ying, S | 1 |
Tan, M | 1 |
Feng, G | 1 |
Kuang, Y | 1 |
Chen, D | 1 |
Wu, D | 3 |
Zhu, ZQ | 1 |
Tang, HX | 1 |
Shi, ZE | 1 |
Kang, J | 1 |
Liu, Q | 1 |
Qi, J | 2 |
Mu, J | 1 |
Cong, Z | 1 |
Chen, S | 2 |
Fu, D | 1 |
Li, Z | 2 |
Celestrin, CP | 1 |
Rocha, GZ | 1 |
Stein, AM | 1 |
Guadagnini, D | 1 |
Tadelle, RM | 1 |
Saad, MJA | 1 |
Oliveira, AG | 1 |
Bianconi, V | 1 |
Bronzo, P | 1 |
Banach, M | 1 |
Sahebkar, A | 1 |
Mannarino, MR | 1 |
Pirro, M | 1 |
Patsourakos, NG | 1 |
Kouvari, M | 1 |
Kotidis, A | 1 |
Kalantzi, KI | 1 |
Tsoumani, ME | 1 |
Anastasiadis, F | 1 |
Andronikos, P | 1 |
Aslanidou, T | 1 |
Efraimidis, P | 1 |
Georgiopoulos, A | 1 |
Gerakiou, K | 1 |
Grigoriadou-Skouta, E | 1 |
Grigoropoulos, P | 1 |
Hatzopoulos, D | 1 |
Kartalis, A | 1 |
Lyras, A | 1 |
Markatos, G | 1 |
Mikrogeorgiou, A | 1 |
Myroforou, I | 1 |
Orkopoulos, A | 1 |
Pavlidis, P | 1 |
Petras, C | 1 |
Riga, M | 1 |
Skouloudi, M | 1 |
Smyrnioudis, N | 1 |
Thomaidis, K | 1 |
Tsikouri, GE | 1 |
Tsikouris, EI | 1 |
Zisimos, K | 1 |
Vavoulis, P | 1 |
Vitali, MG | 1 |
Vitsas, G | 1 |
Vogiatzidis, C | 1 |
Chantanis, S | 1 |
Fousas, S | 1 |
Panagiotakos, DB | 1 |
Tselepis, AD | 1 |
Jungen, C | 1 |
Alken, FA | 1 |
Eickholt, C | 1 |
Scherschel, K | 1 |
Kuklik, P | 1 |
Klatt, N | 1 |
Schwarzl, J | 1 |
Moser, J | 1 |
Jularic, M | 1 |
Akbulak, RO | 1 |
Schaeffer, B | 1 |
Willems, S | 1 |
Meyer, C | 1 |
Nowak, JK | 1 |
Szczepanik, M | 1 |
Trypuć, M | 1 |
Pogorzelski, A | 1 |
Bobkowski, W | 1 |
Grytczuk, M | 1 |
Minarowska, A | 1 |
Wójciak, R | 1 |
Walkowiak, J | 1 |
Lu, Y | 1 |
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Chen, W | 2 |
Hu, X | 1 |
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Wang, Z | 1 |
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Jung, I | 1 |
Sugimura, H | 2 |
Stefan-van Staden, RI | 1 |
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Szederjesi, J | 1 |
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Ehsanbakhsh, Z | 1 |
Validad, MH | 1 |
Langroudi, FH | 1 |
Esfandiari, H | 1 |
Prager, A | 1 |
Hassanpour, K | 1 |
Kurup, SP | 1 |
Mets-Halgrimson, R | 1 |
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Zeid, JL | 1 |
Mets, MB | 1 |
Rahmani, B | 1 |
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Culquichicón, C | 1 |
Solis Condor, R | 1 |
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Hadisuyatmana, S | 1 |
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Ahmadi, F | 1 |
Moayer, F | 1 |
Khalvati, S | 1 |
Zhang, Q | 2 |
Lyu, Y | 1 |
Huang, J | 1 |
Yu, N | 1 |
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Zhao, T | 1 |
Gupta, A | 1 |
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Govindasamy, V | 1 |
Saini, A | 1 |
Annapurna, K | 1 |
Dhakate, SR | 1 |
Akkaya, Ö | 1 |
Chandgude, AL | 1 |
Dömling, A | 1 |
Harnett, J | 1 |
Oakes, K | 1 |
Carè, J | 1 |
Leach, M | 1 |
Brown, D | 1 |
Cramer, H | 1 |
Pinder, TA | 1 |
Steel, A | 1 |
Anheyer, D | 1 |
Cantu, J | 1 |
Valle, J | 1 |
Flores, K | 1 |
Gonzalez, D | 1 |
Valdes, C | 1 |
Lopez, J | 1 |
Padilla, V | 1 |
Alcoutlabi, M | 1 |
Parsons, J | 1 |
Núñez, K | 1 |
Hamed, M | 1 |
Fort, D | 1 |
Bruce, D | 1 |
Thevenot, P | 1 |
Cohen, A | 1 |
Weber, P | 1 |
Menezes, AMB | 1 |
Gonçalves, H | 1 |
Perez-Padilla, R | 1 |
Jarvis, D | 1 |
de Oliveira, PD | 1 |
Wehrmeister, FC | 1 |
Mir, S | 1 |
Wong, J | 1 |
Ryan, CM | 1 |
Bellingham, G | 1 |
Singh, M | 2 |
Waseem, R | 1 |
Eckert, DJ | 1 |
Chung, F | 1 |
Hegde, H | 1 |
Shimpi, N | 1 |
Panny, A | 1 |
Glurich, I | 1 |
Christie, P | 1 |
Acharya, A | 1 |
English, KL | 1 |
Downs, M | 1 |
Goetchius, E | 1 |
Buxton, R | 1 |
Ryder, JW | 1 |
Ploutz-Snyder, R | 1 |
Guilliams, M | 1 |
Scott, JM | 1 |
Ploutz-Snyder, LL | 1 |
Martens, C | 1 |
Goplen, FK | 1 |
Aasen, T | 1 |
Gjestad, R | 1 |
Nordfalk, KF | 1 |
Nordahl, SHG | 1 |
Inoue, T | 1 |
Soshi, S | 1 |
Kubota, M | 1 |
Marumo, K | 1 |
Mortensen, NP | 1 |
Caffaro, MM | 1 |
Patel, PR | 2 |
Uddin, MJ | 1 |
Aravamudhan, S | 1 |
Sumner, SJ | 1 |
Fennell, TR | 1 |
Gal, RL | 1 |
Cohen, NJ | 1 |
Kruger, D | 1 |
Beck, RW | 1 |
Bergenstal, RM | 1 |
Calhoun, P | 1 |
Cushman, T | 1 |
Haban, A | 1 |
Hood, K | 1 |
Johnson, ML | 1 |
McArthur, T | 1 |
Olson, BA | 1 |
Weinstock, RS | 1 |
Oser, SM | 1 |
Oser, TK | 1 |
Bugielski, B | 1 |
Strayer, H | 1 |
Aleppo, G | 1 |
Maruyama, H | 1 |
Hirayama, K | 1 |
Yamashita, M | 1 |
Ohgi, K | 1 |
Tsujimoto, R | 1 |
Takayasu, M | 1 |
Shimohata, H | 1 |
Kobayashi, M | 1 |
Buscagan, TM | 1 |
Rees, DC | 1 |
Jaborek, JR | 1 |
Zerby, HN | 1 |
Wick, MP | 1 |
Fluharty, FL | 1 |
Moeller, SJ | 1 |
Razavi, P | 1 |
Dickler, MN | 1 |
Shah, PD | 1 |
Toy, W | 1 |
Brown, DN | 1 |
Won, HH | 1 |
Li, BT | 1 |
Shen, R | 1 |
Vasan, N | 1 |
Modi, S | 1 |
Jhaveri, K | 1 |
Caravella, BA | 1 |
Patil, S | 1 |
Selenica, P | 1 |
Zamora, S | 1 |
Cowan, AM | 1 |
Comen, E | 1 |
Singh, A | 1 |
Covey, A | 1 |
Berger, MF | 1 |
Hudis, CA | 1 |
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Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Double-blind, Randomized, Placebo-controlled, Parallel Design Study to Evaluate the Effects of the Cardio Formulation on Oxidized LDL in Individuals Who Are Overweight to Mildly Obese and Otherwise Healthy[NCT04317287] | 9 participants (Actual) | Interventional | 2019-12-10 | Terminated (stopped due to COVID-19 Pandemic) | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
2 reviews available for metformin and Periodontitis
Article | Year |
---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Caloric restriction and chronic inflammatory diseases.
Topics: Adaptive Immunity; Animals; Biomimetics; Caloric Restriction; Cardiovascular Diseases; Chronic Disea | 2012 |
1 trial available for metformin and Periodontitis
Article | Year |
---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
10 other studies available for metformin and Periodontitis
Article | Year |
---|---|
Metformin-loaded β-TCP/CTS/SBA-15 composite scaffolds promote alveolar bone regeneration in a rat model of periodontitis.
Topics: Alveolar Process; Animals; Bone Marrow Cells; Bone Regeneration; Calcium Phosphates; Cell Survival; | 2021 |
The anti-periodontitis action of metformin via targeting NLRP3 inflammasome.
Topics: Caspase 1; Cells, Cultured; Humans; Inflammasomes; Interleukin-18; Interleukin-1beta; Lipopolysaccha | 2020 |
Metformin ameliorates the NLPP3 inflammasome mediated pyroptosis by inhibiting the expression of NEK7 in diabetic periodontitis.
Topics: Animals; Diabetes Complications; Diabetes Mellitus; Inflammasomes; Metformin; Mice; NIMA-Related Kin | 2020 |
Impact of hyperglycemia and treatment with metformin on ligature-induced bone loss, bone repair and expression of bone metabolism transcription factors.
Topics: Alveolar Bone Loss; Alveolar Process; Animals; Bone Regeneration; Cell Differentiation; Cytokines; D | 2020 |
Alteration of salivary microbiome in periodontitis with or without type-2 diabetes mellitus and metformin treatment.
Topics: Adult; Bacteroidetes; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Metformi | 2020 |
Effects of metformin on inflammation, oxidative stress, and bone loss in a rat model of periodontitis.
Topics: Alveolar Bone Loss; Animals; Disease Models, Animal; Gingiva; Glutathione Peroxidase; Glutathione Pe | 2017 |
Development and evaluation of novel biodegradable chitosan based metformin intrapocket dental film for the management of periodontitis and alveolar bone loss in a rat model.
Topics: Alveolar Bone Loss; Animals; Anti-Bacterial Agents; Chitosan; Disease Models, Animal; Drug Implants; | 2018 |
Metformin ameliorates experimental diabetic periodontitis independently of mammalian target of rapamycin (mTOR) inhibition by reducing NIMA-related kinase 7 (Nek7) expression.
Topics: Animals; Diabetes Mellitus, Experimental; Interleukin-1beta; Metformin; Mice; NIMA-Related Kinases; | 2019 |
Thiolated alginate-based multiple layer mucoadhesive films of metformin forintra-pocket local delivery: in vitro characterization and clinical assessment.
Topics: Adult; Alginates; Animals; Delayed-Action Preparations; Dental Cements; Drug Delivery Systems; Femal | 2017 |
The effect of metformin on alveolar bone in ligature-induced periodontitis in rats: a pilot study.
Topics: 3T3 Cells; Adipocytes; Alveolar Bone Loss; Animals; Cell Differentiation; Hypoglycemic Agents; Injec | 2010 |