metformin has been researched along with Ovarian Hyperstimulation Syndrome in 24 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Ovarian Hyperstimulation Syndrome: A complication of OVULATION INDUCTION in infertility treatment. It is graded by the severity of symptoms which include OVARY enlargement, multiple OVARIAN FOLLICLES; OVARIAN CYSTS; ASCITES; and generalized EDEMA. The full-blown syndrome may lead to RENAL FAILURE, respiratory distress, and even DEATH. Increased capillary permeability is caused by the vasoactive substances, such as VASCULAR ENDOTHELIAL GROWTH FACTORS, secreted by the overly-stimulated OVARIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Berberine and metformin treatments prior to IVF improved the pregnancy outcome by normalizing the clinical, endocrine and metabolic parameters in PCOS women." | 9.19 | The use of berberine for women with polycystic ovary syndrome undergoing IVF treatment. ( An, Y; Guan, Y; Liu, B; Lu, M; Sun, Z; Zhang, Y, 2014) |
| "To test whether metformin administration reduces the incidence of ovarian hyperstimulation syndrome (OHSS) in infertile high-risk patients with polycystic ovary syndrome (PCOS) who have been treated with gonadotropins for IVF." | 9.15 | Metformin reduces risk of ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome during gonadotropin-stimulated in vitro fertilization cycles: a randomized, controlled trial. ( Capasso, S; Cappiello, F; Carrillo, L; Cittadini, E; Colao, A; Di Cello, A; Falbo, A; La Sala, GB; Mastrantonio, P; Orio, F; Palomba, S; Russo, T; Tolino, A; Villani, MT; Zullo, F, 2011) |
| "Metformin effectively restores insulin sensitivity in insulin-resistant women with polycystic ovary syndrome (PCOS)." | 9.10 | The effect of metformin on ovarian stimulation and in vitro fertilization in insulin-resistant women with polycystic ovary syndrome: an open-label randomized cross-over trial. ( Abyholm, T; Dale, PO; Fedorcsák, P; Storeng, R; Tanbo, T, 2003) |
| "In women with polycystic ovary syndrome, metformin treatment before or during assisted reproductive technology cycles increases clinical pregnancy rates and decreases the risk of ovarian hyperstimulation syndrome." | 8.91 | Metformin treatment before and during in vitro fertilization or intracytoplasmic sperm injection in women with polycystic ovary syndrome: summary of a Cochrane review. ( Albuquerque, LE; Andriolo, RB; Costello, MF; Macedo, CR; Marjoribanks, J; Tso, LO, 2015) |
| "Metformin is used among patients with polycystic ovary syndrome (PCOS), but findings for its effects on outcomes of assisted reproductive technology (ART) have been conflicting." | 8.91 | A systematic review and meta-analysis of metformin among patients with polycystic ovary syndrome undergoing assisted reproductive technology procedures. ( Huang, X; Li, Y; Lv, F; Tal, R; Wang, P; Zhang, X, 2015) |
| "Metformin is widely used for treating women with polycystic ovary syndrome (PCOS), and many patients with PCOS who are infertile receive gonadotrophins while being treated with metformin." | 8.89 | Effects of metformin in women with polycystic ovary syndrome treated with gonadotrophins for in vitro fertilisation and intracytoplasmic sperm injection cycles: a systematic review and meta-analysis of randomised controlled trials. ( Falbo, A; La Sala, GB; Palomba, S, 2013) |
| "The usefulness of various pathways inhibitors, Everolimus, an inhibitor of mammalian target of rapamycin (mTOR), Infliximab, a monoclonal antibody which blocks the tumor necrosis factor-a (TNF-a), Erlotinib, a tyrosine protein kinase inhibitor of the epidermal growth factor receptor (EGFR), Metformin, an activator of AMP-activated protein kinase enzyme (AMPK) and vascular permeability reducers were explored in an ovarian hyperstimulation syndrome (OHSS) rat model." | 7.81 | Everolimus, an mTOR pathway inhibitor, is highly successful on ovarian hyperstimulation syndrome by reducing ovarian weight and progesterone levels: a preclinical experimental randomized controlled study. ( Galani, V; Georgiou, I; Kitsou, C; Kosmas, IP; Lazaros, L; Markoula, S; Mynbaev, O; Peschos, D; Prapas, I; Prapas, N; Tournaye, H; Zikopoulos, A, 2015) |
| " Women who had elective cryopreservation due to ovarian hyperstimulation syndrome risk were found to have significantly higher LBRs if metformin was taken in the fresh IVF/ICSI cycle (A = 44." | 7.76 | Effect of metformin taken in the 'fresh' in vitro fertilization/intracytoplasmic sperm injection cycle upon subsequent frozen embryo replacement in women with polycystic ovary syndrome. ( Acharya, S; Balen, A; Brewer, C; Tang, T; Thake, F, 2010) |
| "Metformin is a safe, cheap drug that can help in prevention of OHSS." | 6.72 | Use of metformin for prevention of ovarian hyperstimulation syndrome: a novel approach. ( Fotouh, IA; Khattab, S; Metwally, M; Moaz, M; Mohesn, IA, 2006) |
| "Letrozole-treated patients required a significantly lower amount of gonadotropins units (p < 0." | 5.48 | Mild ovarian stimulation with letrozole plus fixed dose human menopausal gonadotropin prior to IVF/ICSI for infertile non-obese women with polycystic ovarian syndrome being pre-treated with metformin: a pilot study. ( Cantatore, C; Caringella, AM; Caroppo, E; D'Amato, G; Palini, S; Stanziano, A, 2018) |
| "Berberine and metformin treatments prior to IVF improved the pregnancy outcome by normalizing the clinical, endocrine and metabolic parameters in PCOS women." | 5.19 | The use of berberine for women with polycystic ovary syndrome undergoing IVF treatment. ( An, Y; Guan, Y; Liu, B; Lu, M; Sun, Z; Zhang, Y, 2014) |
| " In women with PCOS, metformin co-treatment during IVF has been shown to increase pregnancy rates and reduce the risk of ovarian hyperstimulation syndrome (OHSS)." | 5.15 | Do women with ovaries of polycystic morphology without any other features of PCOS benefit from short-term metformin co-treatment during IVF? A double-blind, placebo-controlled, randomized trial. ( Child, T; Granne, I; Jayaprakasan, K; Lavery, S; Lighten, A; McVeigh, E; Raine-Fenning, N; Swanton, A; Talmor, A; Trew, G, 2011) |
| "To test whether metformin administration reduces the incidence of ovarian hyperstimulation syndrome (OHSS) in infertile high-risk patients with polycystic ovary syndrome (PCOS) who have been treated with gonadotropins for IVF." | 5.15 | Metformin reduces risk of ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome during gonadotropin-stimulated in vitro fertilization cycles: a randomized, controlled trial. ( Capasso, S; Cappiello, F; Carrillo, L; Cittadini, E; Colao, A; Di Cello, A; Falbo, A; La Sala, GB; Mastrantonio, P; Orio, F; Palomba, S; Russo, T; Tolino, A; Villani, MT; Zullo, F, 2011) |
| "Metformin effectively restores insulin sensitivity in insulin-resistant women with polycystic ovary syndrome (PCOS)." | 5.10 | The effect of metformin on ovarian stimulation and in vitro fertilization in insulin-resistant women with polycystic ovary syndrome: an open-label randomized cross-over trial. ( Abyholm, T; Dale, PO; Fedorcsák, P; Storeng, R; Tanbo, T, 2003) |
| " Further we tried to identify the preventive influence of metformin on development of ovarian hyperstimulation syndrome." | 5.10 | [Importance of sensitization of insulin receptors in the prevention of ovarian hyperstimulation syndrome]. ( Crha, I; Ventruba, P; Visnová, H; Záková, J, 2003) |
| "In women with polycystic ovary syndrome, metformin treatment before or during assisted reproductive technology cycles increases clinical pregnancy rates and decreases the risk of ovarian hyperstimulation syndrome." | 4.91 | Metformin treatment before and during in vitro fertilization or intracytoplasmic sperm injection in women with polycystic ovary syndrome: summary of a Cochrane review. ( Albuquerque, LE; Andriolo, RB; Costello, MF; Macedo, CR; Marjoribanks, J; Tso, LO, 2015) |
| "Metformin is used among patients with polycystic ovary syndrome (PCOS), but findings for its effects on outcomes of assisted reproductive technology (ART) have been conflicting." | 4.91 | A systematic review and meta-analysis of metformin among patients with polycystic ovary syndrome undergoing assisted reproductive technology procedures. ( Huang, X; Li, Y; Lv, F; Tal, R; Wang, P; Zhang, X, 2015) |
| "Metformin is widely used for treating women with polycystic ovary syndrome (PCOS), and many patients with PCOS who are infertile receive gonadotrophins while being treated with metformin." | 4.89 | Effects of metformin in women with polycystic ovary syndrome treated with gonadotrophins for in vitro fertilisation and intracytoplasmic sperm injection cycles: a systematic review and meta-analysis of randomised controlled trials. ( Falbo, A; La Sala, GB; Palomba, S, 2013) |
| "The usefulness of various pathways inhibitors, Everolimus, an inhibitor of mammalian target of rapamycin (mTOR), Infliximab, a monoclonal antibody which blocks the tumor necrosis factor-a (TNF-a), Erlotinib, a tyrosine protein kinase inhibitor of the epidermal growth factor receptor (EGFR), Metformin, an activator of AMP-activated protein kinase enzyme (AMPK) and vascular permeability reducers were explored in an ovarian hyperstimulation syndrome (OHSS) rat model." | 3.81 | Everolimus, an mTOR pathway inhibitor, is highly successful on ovarian hyperstimulation syndrome by reducing ovarian weight and progesterone levels: a preclinical experimental randomized controlled study. ( Galani, V; Georgiou, I; Kitsou, C; Kosmas, IP; Lazaros, L; Markoula, S; Mynbaev, O; Peschos, D; Prapas, I; Prapas, N; Tournaye, H; Zikopoulos, A, 2015) |
| " Women who had elective cryopreservation due to ovarian hyperstimulation syndrome risk were found to have significantly higher LBRs if metformin was taken in the fresh IVF/ICSI cycle (A = 44." | 3.76 | Effect of metformin taken in the 'fresh' in vitro fertilization/intracytoplasmic sperm injection cycle upon subsequent frozen embryo replacement in women with polycystic ovary syndrome. ( Acharya, S; Balen, A; Brewer, C; Tang, T; Thake, F, 2010) |
| "To evaluate the effect of metformin addition during ovarian hyperstimulation on cycle parameters and outcome of in vitro fertilization (IVF) treatment in polycystic ovary syndrome (PCOS) patients with a body mass index (BMI) <28 kg/m(2)." | 3.75 | Efficacy of metformin supplementation during ovarian stimulation of lean PCOS patients undergoing in vitro fertilization. ( Kahraman, S; Kumbak, B, 2009) |
| "Metformin is a safe, cheap drug that can help in prevention of OHSS." | 2.72 | Use of metformin for prevention of ovarian hyperstimulation syndrome: a novel approach. ( Fotouh, IA; Khattab, S; Metwally, M; Moaz, M; Mohesn, IA, 2006) |
| "It has also been widely used in the treatment of polycystic ovary syndrome (PCOS) and gestational diabetes mellitus." | 2.53 | Role of Metformin in Women's Health: Review of Its Current Place in Clinical Practice and Emerging Indications for Future. ( Sinai Talaulikar, V; Tang, T; Yasmin, E, 2016) |
| "Ovarian hyperstimulation syndrome is an important condition with considerable morbidity and a small risk of mortality, which most commonly results as an iatrogenic condition following follicular stimulation of the ovaries." | 2.52 | Consensus statement on prevention and detection of ovarian hyperstimulation syndrome. ( Andreadis, N; Boothroyd, C; Chapman, M; Johnson, N; Karia, S; Rombauts, L, 2015) |
| "Letrozole-treated patients required a significantly lower amount of gonadotropins units (p < 0." | 1.48 | Mild ovarian stimulation with letrozole plus fixed dose human menopausal gonadotropin prior to IVF/ICSI for infertile non-obese women with polycystic ovarian syndrome being pre-treated with metformin: a pilot study. ( Cantatore, C; Caringella, AM; Caroppo, E; D'Amato, G; Palini, S; Stanziano, A, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (25.00) | 29.6817 |
| 2010's | 16 (66.67) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Rajasekaran, K | 1 |
| Malhotra, N | 1 |
| Mahey, R | 2 |
| Khadgawat, R | 1 |
| Kalaivani, M | 1 |
| Gupta, M | 1 |
| Bansiwal, R | 1 |
| Sethi, A | 1 |
| D'Amato, G | 1 |
| Caringella, AM | 1 |
| Stanziano, A | 1 |
| Cantatore, C | 1 |
| Palini, S | 1 |
| Caroppo, E | 1 |
| An, Y | 1 |
| Sun, Z | 1 |
| Zhang, Y | 1 |
| Liu, B | 1 |
| Guan, Y | 1 |
| Lu, M | 1 |
| Tso, LO | 1 |
| Costello, MF | 1 |
| Albuquerque, LE | 1 |
| Andriolo, RB | 1 |
| Marjoribanks, J | 1 |
| Macedo, CR | 1 |
| Kosmas, IP | 1 |
| Kitsou, C | 1 |
| Lazaros, L | 1 |
| Markoula, S | 1 |
| Peschos, D | 1 |
| Mynbaev, O | 1 |
| Tournaye, H | 1 |
| Prapas, N | 1 |
| Prapas, I | 1 |
| Zikopoulos, A | 1 |
| Galani, V | 1 |
| Georgiou, I | 1 |
| Huang, X | 1 |
| Wang, P | 1 |
| Tal, R | 1 |
| Lv, F | 1 |
| Li, Y | 1 |
| Zhang, X | 1 |
| Boothroyd, C | 1 |
| Karia, S | 1 |
| Andreadis, N | 1 |
| Rombauts, L | 1 |
| Johnson, N | 1 |
| Chapman, M | 1 |
| Sinai Talaulikar, V | 1 |
| Tang, T | 3 |
| Yasmin, E | 1 |
| Balen, AH | 2 |
| Morley, LC | 1 |
| Misso, M | 1 |
| Franks, S | 1 |
| Legro, RS | 1 |
| Wijeyaratne, CN | 1 |
| Stener-Victorin, E | 1 |
| Fauser, BC | 1 |
| Norman, RJ | 1 |
| Teede, H | 1 |
| Jacob, SL | 1 |
| Brewer, C | 2 |
| Picton, HM | 1 |
| Barth, JH | 1 |
| Mourad, S | 1 |
| Brown, J | 1 |
| Farquhar, C | 1 |
| Nelson, SM | 1 |
| Kumbak, B | 1 |
| Kahraman, S | 1 |
| Acharya, S | 1 |
| Thake, F | 1 |
| Balen, A | 1 |
| Genazzani, AR | 1 |
| Monteleone, P | 1 |
| Papini, F | 1 |
| Artini, PG | 1 |
| Swanton, A | 1 |
| Lighten, A | 1 |
| Granne, I | 1 |
| McVeigh, E | 1 |
| Lavery, S | 1 |
| Trew, G | 1 |
| Talmor, A | 1 |
| Raine-Fenning, N | 1 |
| Jayaprakasan, K | 1 |
| Child, T | 1 |
| Palomba, S | 3 |
| Falbo, A | 3 |
| Carrillo, L | 1 |
| Villani, MT | 1 |
| Orio, F | 2 |
| Russo, T | 2 |
| Di Cello, A | 1 |
| Cappiello, F | 1 |
| Capasso, S | 1 |
| Tolino, A | 2 |
| Colao, A | 1 |
| Mastrantonio, P | 1 |
| La Sala, GB | 2 |
| Zullo, F | 2 |
| Cittadini, E | 1 |
| Fedorcsák, P | 1 |
| Dale, PO | 1 |
| Storeng, R | 1 |
| Abyholm, T | 1 |
| Tanbo, T | 1 |
| Visnová, H | 1 |
| Ventruba, P | 1 |
| Crha, I | 1 |
| Záková, J | 1 |
| Manguso, F | 1 |
| Annamaria, C | 1 |
| Dale, B | 1 |
| Doldi, N | 1 |
| Persico, P | 1 |
| Di Sebastiano, F | 1 |
| Marsiglio, E | 1 |
| Ferrari, A | 1 |
| Khattab, S | 1 |
| Fotouh, IA | 1 |
| Mohesn, IA | 1 |
| Metwally, M | 1 |
| Moaz, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter Randomized Trial of Personalized Acupuncture, Fixed Acupuncture, Letrozole and Placebo on Live Birth for Infertility in Women With Polycystic Ovary Syndrome[NCT03625531] | Phase 3 | 1,100 participants (Anticipated) | Interventional | 2018-08-13 | Recruiting | ||
| Metformin Treatment Before IVF in Women With Ultrasound Evidence of Polycystic Ovaries; a Prospective, Randomised, Double Blind, Placebo Study[NCT01046032] | 134 participants (Actual) | Interventional | 2005-12-31 | Completed | |||
| Metformin Addition to Gonadotropins Ovarian Stimulation in High Responder Patients With PCOS Undergoing In-vitro Fertilization[NCT01233206] | Phase 4 | 120 participants (Actual) | Interventional | 2009-05-31 | Completed | ||
| Is the Co-administration of Metformine and CC as Compared to Placebo and CC Superior to Induce Ovulation in PCOS Patients With a Confirmed insulin-resistant-a Double Blind Randomized Clinical Trial[NCT02523898] | Phase 2 | 388 participants (Anticipated) | Interventional | 2015-11-30 | Enrolling by invitation | ||
| What is the Following Step to Improve Fertility in Infertile PCOS Patients Ovulating Under Clomiphene Citrate or Metformin? A Randomized Controlled Clinical Study.[NCT00502229] | Phase 4 | 0 participants (Actual) | Interventional | 2010-01-31 | Withdrawn | ||
| A Multicenter, Prospective, Randomized Study to Assess the Effect of Metformin Supplementation on IVF Outcome and Intrafollicular Environment in Patients With Polycystic Ovarian Syndrome Undergoing In Vitro Fertilization/Embryo Transfer[NCT03086005] | Phase 3 | 24 participants (Actual) | Interventional | 2011-10-12 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for metformin and Ovarian Hyperstimulation Syndrome
| Article | Year |
|---|---|
Metformin treatment before and during in vitro fertilization or intracytoplasmic sperm injection in women with polycystic ovary syndrome: summary of a Cochrane review.
Topics: Chi-Square Distribution; Female; Fertility; Fertilization in Vitro; Humans; Hypoglycemic Agents; Inf | 2015 |
A systematic review and meta-analysis of metformin among patients with polycystic ovary syndrome undergoing assisted reproductive technology procedures.
Topics: Abortion, Spontaneous; Adult; Female; Humans; Hypoglycemic Agents; Live Birth; Metformin; Ovarian Hy | 2015 |
Consensus statement on prevention and detection of ovarian hyperstimulation syndrome.
Topics: Consensus; Cryopreservation; Embryo, Mammalian; Evidence-Based Medicine; Female; Follicle Stimulatin | 2015 |
Role of Metformin in Women's Health: Review of Its Current Place in Clinical Practice and Emerging Indications for Future.
Topics: Anticarcinogenic Agents; Clomiphene; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Ferti | 2016 |
The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance.
Topics: Anovulation; Aromatase Inhibitors; Clomiphene; Consensus; Female; Fertility Agents, Female; Fertiliz | 2016 |
Interventions for the prevention of OHSS in ART cycles: an overview of Cochrane reviews.
Topics: Cabergoline; Ergolines; Female; Gonadotropin-Releasing Hormone; Humans; Metformin; Ovarian Hyperstim | 2017 |
Prevention and management of ovarian hyperstimulation syndrome.
Topics: Aspirin; Calcium Gluconate; Cyclooxygenase Inhibitors; Disease Management; Dopamine Agonists; Female | 2017 |
Pharmacotherapy of ovarian hyperstimulation syndrome.
Topics: Acetaminophen; Animals; Female; Hormone Antagonists; Humans; Metformin; Ovarian Hyperstimulation Syn | 2010 |
Effects of metformin in women with polycystic ovary syndrome treated with gonadotrophins for in vitro fertilisation and intracytoplasmic sperm injection cycles: a systematic review and meta-analysis of randomised controlled trials.
Topics: Abortion, Spontaneous; Dinoprostone; Embryo Implantation; Female; Fertility Agents, Female; Fertiliz | 2013 |
10 trials available for metformin and Ovarian Hyperstimulation Syndrome
5 other studies available for metformin and Ovarian Hyperstimulation Syndrome
| Article | Year |
|---|---|
Successful IVF outcome after repeat laparoscopic ovarian drilling in a case of resistant PCOS.
Topics: Abortion, Habitual; Adult; Female; Fertilization in Vitro; Glucose Metabolism Disorders; Humans; Hyp | 2020 |
Mild ovarian stimulation with letrozole plus fixed dose human menopausal gonadotropin prior to IVF/ICSI for infertile non-obese women with polycystic ovarian syndrome being pre-treated with metformin: a pilot study.
Topics: Adult; Female; Gonadotropins; Humans; Infertility, Female; Letrozole; Metformin; Nitriles; Oocyte Re | 2018 |
Everolimus, an mTOR pathway inhibitor, is highly successful on ovarian hyperstimulation syndrome by reducing ovarian weight and progesterone levels: a preclinical experimental randomized controlled study.
Topics: AMP-Activated Protein Kinases; Animals; Capillary Permeability; Chorionic Gonadotropin; Erlotinib Hy | 2015 |
Efficacy of metformin supplementation during ovarian stimulation of lean PCOS patients undergoing in vitro fertilization.
Topics: Adult; Blood Glucose; Body Mass Index; Case-Control Studies; Chorionic Gonadotropin; Dinoprostone; E | 2009 |
Effect of metformin taken in the 'fresh' in vitro fertilization/intracytoplasmic sperm injection cycle upon subsequent frozen embryo replacement in women with polycystic ovary syndrome.
Topics: Adult; Birth Rate; Cryopreservation; Embryo Transfer; Female; Fertilization in Vitro; Humans; Hyperi | 2010 |