metformin has been researched along with Osteogenic Sarcoma in 18 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We found that metformin (Met) induces CD11b+-cell-mediated growth inhibition of a K7M2neo osteosarcoma independent of T cells, as growth inhibition of K7M2neo was still observed in wild-type (WT) mice depleted of T cells by antibodies and in SCID; this contrasted with the effect of Met on Meth A fibrosarcoma, which was entirely T-cell-dependent." | 7.91 | Metformin induces CD11b+-cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and anti-tumor effects. ( Eikawa, S; Fujiwara, T; Kunisada, T; Kunisada, Y; Nishida, M; Ozaki, T; Udono, H; Uehara, T; Yoshida, A, 2019) |
| "This preclinical study suggests that Metformin may be a potentially useful therapeutic agent and chemosensitizer of osteosarcoma stem-like cells to doxorubicin." | 7.88 | Therapeutic potential of the metabolic modulator Metformin on osteosarcoma cancer stem-like cells. ( Abrunhosa, AJ; Fontes-Ribeiro, C; Gomes, CMF; Martins-Neves, SR; Paiva-Oliveira, DI, 2018) |
| "Metformin can enhance cancer cell chemosensitivity to anticancer drugs." | 5.91 | Metformin sensitises osteosarcoma to chemotherapy via the IGF-1R/miR-610/FEN1 pathway. ( Dong, S; Kang, J; Li, Z; Ma, X; Peng, Z; Wang, J; Wang, Y; Xiao, Y; Zhu, Z, 2023) |
| "Osteosarcoma is the most frequently diagnosed primary malignant bone sarcoma in children and adolescents." | 5.51 | Metformin Suppresses Self-Renewal Ability and Tumorigenicity of Osteosarcoma Stem Cells via Reactive Oxygen Species-Mediated Apoptosis and Autophagy. ( Che, J; Luo, J; Peng, S; Shang, P; Wang, F; Wang, Y; Zhang, G; Zhao, B; Zhou, L, 2019) |
| "Metformin attenuates the metastasis and autophagy in osteosarcoma." | 5.48 | Inhibition of LCMR1 and ATG12 by demethylation-activated miR-570-3p is involved in the anti-metastasis effects of metformin on human osteosarcoma. ( Bao, X; Guan, H; Li, F; Zhao, L, 2018) |
| "Metformin treatment of osteosarcoma cells enhanced the effects of chemotherapy via suppression of N-cadherin." | 5.46 | Metformin reduces SATB2-mediated osteosarcoma stem cell-like phenotype and tumor growth via inhibition of N-cadherin/NF-kB signaling. ( Fang, W; Huang, ZW; Kang, Y; Lu, JC; Shen, JN; Song, GH; Tang, QL; Wang, J; Wang, YQ; Xu, HY; Yang, HL; Zhu, XJ; Zou, CY, 2017) |
| "Osteosarcoma is the most common type of primary bone tumor, novel therapeutic agents for which are urgently needed." | 5.46 | Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity. ( Fukuchi, Y; Kamel, WA; Maki, K; Matsuo, K; Muto, A; Nobusue, H; Onishi, N; Saya, H; Shimizu, T; Sugihara, E; Yamaguchi-Iwai, S, 2017) |
| "Metformin is an oral drug that has been widely used to treat type 2 diabetes mellitus." | 5.42 | Metformin inhibits the proliferation, metastasis, and cancer stem-like sphere formation in osteosarcoma MG63 cells in vitro. ( Chen, X; Hu, C; Hu, F; Shen, Y; Wang, J; Yu, P; Zhang, W, 2015) |
| " We found that metformin (Met) induces CD11b+-cell-mediated growth inhibition of a K7M2neo osteosarcoma independent of T cells, as growth inhibition of K7M2neo was still observed in wild-type (WT) mice depleted of T cells by antibodies and in SCID; this contrasted with the effect of Met on Meth A fibrosarcoma, which was entirely T-cell-dependent." | 3.91 | Metformin induces CD11b+-cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and anti-tumor effects. ( Eikawa, S; Fujiwara, T; Kunisada, T; Kunisada, Y; Nishida, M; Ozaki, T; Udono, H; Uehara, T; Yoshida, A, 2019) |
| "This preclinical study suggests that Metformin may be a potentially useful therapeutic agent and chemosensitizer of osteosarcoma stem-like cells to doxorubicin." | 3.88 | Therapeutic potential of the metabolic modulator Metformin on osteosarcoma cancer stem-like cells. ( Abrunhosa, AJ; Fontes-Ribeiro, C; Gomes, CMF; Martins-Neves, SR; Paiva-Oliveira, DI, 2018) |
| "Metformin can enhance cancer cell chemosensitivity to anticancer drugs." | 1.91 | Metformin sensitises osteosarcoma to chemotherapy via the IGF-1R/miR-610/FEN1 pathway. ( Dong, S; Kang, J; Li, Z; Ma, X; Peng, Z; Wang, J; Wang, Y; Xiao, Y; Zhu, Z, 2023) |
| "Osteosarcoma is the most frequently diagnosed primary malignant bone sarcoma in children and adolescents." | 1.51 | Metformin Suppresses Self-Renewal Ability and Tumorigenicity of Osteosarcoma Stem Cells via Reactive Oxygen Species-Mediated Apoptosis and Autophagy. ( Che, J; Luo, J; Peng, S; Shang, P; Wang, F; Wang, Y; Zhang, G; Zhao, B; Zhou, L, 2019) |
| "Osteosarcoma is an aggressive bone tumor characterized by biological and molecular heterogeneity, possibly dependent on CSCs." | 1.48 | In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity. ( Bajetto, A; Barbieri, F; Campanella, C; Corsaro, A; Daga, A; De Maria, R; Ferrari, A; Florio, T; Gatti, M; Maniscalco, L; Pattarozzi, A; Ratto, A; Solari, A; Thellung, S; Würth, R, 2018) |
| "Metformin attenuates the metastasis and autophagy in osteosarcoma." | 1.48 | Inhibition of LCMR1 and ATG12 by demethylation-activated miR-570-3p is involved in the anti-metastasis effects of metformin on human osteosarcoma. ( Bao, X; Guan, H; Li, F; Zhao, L, 2018) |
| "Metformin treatment of osteosarcoma cells enhanced the effects of chemotherapy via suppression of N-cadherin." | 1.46 | Metformin reduces SATB2-mediated osteosarcoma stem cell-like phenotype and tumor growth via inhibition of N-cadherin/NF-kB signaling. ( Fang, W; Huang, ZW; Kang, Y; Lu, JC; Shen, JN; Song, GH; Tang, QL; Wang, J; Wang, YQ; Xu, HY; Yang, HL; Zhu, XJ; Zou, CY, 2017) |
| "Osteosarcoma is the most common type of primary bone tumor, novel therapeutic agents for which are urgently needed." | 1.46 | Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity. ( Fukuchi, Y; Kamel, WA; Maki, K; Matsuo, K; Muto, A; Nobusue, H; Onishi, N; Saya, H; Shimizu, T; Sugihara, E; Yamaguchi-Iwai, S, 2017) |
| "Metformin is an oral drug that has been widely used to treat type 2 diabetes mellitus." | 1.42 | Metformin inhibits the proliferation, metastasis, and cancer stem-like sphere formation in osteosarcoma MG63 cells in vitro. ( Chen, X; Hu, C; Hu, F; Shen, Y; Wang, J; Yu, P; Zhang, W, 2015) |
| "Metformin-treatment of osteoblastic cells prevented these AGE-induced alterations." | 1.35 | Metformin reverts deleterious effects of advanced glycation end-products (AGEs) on osteoblastic cells. ( Arnol, V; Bruzzone, L; Cortizo, AM; Gangoiti, MV; McCarthy, AD; Schurman, L; Sedlinsky, C, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 14 (77.78) | 24.3611 |
| 2020's | 3 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Dong, S | 1 |
| Xiao, Y | 1 |
| Zhu, Z | 1 |
| Ma, X | 1 |
| Peng, Z | 1 |
| Kang, J | 1 |
| Wang, J | 3 |
| Wang, Y | 2 |
| Li, Z | 1 |
| Huang, S | 1 |
| Ren, L | 1 |
| Beck, JA | 1 |
| Phelps, TE | 1 |
| Olkowski, C | 1 |
| Ton, A | 1 |
| Roy, J | 1 |
| White, ME | 1 |
| Adler, S | 1 |
| Wong, K | 1 |
| Cherukuri, A | 1 |
| Zhang, X | 1 |
| Basuli, F | 1 |
| Choyke, PL | 1 |
| Jagoda, EM | 1 |
| LeBlanc, AK | 1 |
| Zhao, B | 1 |
| Luo, J | 1 |
| Zhou, L | 1 |
| Che, J | 1 |
| Wang, F | 1 |
| Peng, S | 1 |
| Zhang, G | 1 |
| Shang, P | 1 |
| Li, B | 1 |
| Zhou, P | 1 |
| Xu, K | 1 |
| Chen, T | 1 |
| Jiao, J | 1 |
| Wei, H | 1 |
| Yang, X | 1 |
| Xu, W | 1 |
| Wan, W | 1 |
| Xiao, J | 1 |
| Shang, D | 1 |
| Wu, J | 1 |
| Guo, L | 1 |
| Xu, Y | 1 |
| Liu, L | 1 |
| Lu, J | 1 |
| Paiva-Oliveira, DI | 1 |
| Martins-Neves, SR | 1 |
| Abrunhosa, AJ | 1 |
| Fontes-Ribeiro, C | 1 |
| Gomes, CMF | 1 |
| Xu, HY | 1 |
| Fang, W | 1 |
| Huang, ZW | 1 |
| Lu, JC | 1 |
| Wang, YQ | 1 |
| Tang, QL | 1 |
| Song, GH | 1 |
| Kang, Y | 1 |
| Zhu, XJ | 1 |
| Zou, CY | 1 |
| Yang, HL | 1 |
| Shen, JN | 1 |
| Gatti, M | 1 |
| Solari, A | 1 |
| Pattarozzi, A | 1 |
| Campanella, C | 1 |
| Thellung, S | 1 |
| Maniscalco, L | 1 |
| De Maria, R | 1 |
| Würth, R | 1 |
| Corsaro, A | 1 |
| Bajetto, A | 1 |
| Ratto, A | 1 |
| Ferrari, A | 1 |
| Daga, A | 1 |
| Barbieri, F | 1 |
| Florio, T | 1 |
| Bao, X | 1 |
| Zhao, L | 1 |
| Guan, H | 1 |
| Li, F | 1 |
| Uehara, T | 1 |
| Eikawa, S | 1 |
| Nishida, M | 1 |
| Kunisada, Y | 1 |
| Yoshida, A | 1 |
| Fujiwara, T | 1 |
| Kunisada, T | 1 |
| Ozaki, T | 1 |
| Udono, H | 1 |
| Duo, J | 1 |
| Ma, Y | 1 |
| Wang, G | 1 |
| Han, X | 1 |
| Zhang, C | 1 |
| Quattrini, I | 1 |
| Conti, A | 1 |
| Pazzaglia, L | 1 |
| Novello, C | 1 |
| Ferrari, S | 1 |
| Picci, P | 2 |
| Benassi, MS | 1 |
| Garofalo, C | 1 |
| Capristo, M | 1 |
| Manara, MC | 1 |
| Mancarella, C | 1 |
| Landuzzi, L | 1 |
| Belfiore, A | 1 |
| Lollini, PL | 1 |
| Scotlandi, K | 1 |
| Issaq, SH | 1 |
| Teicher, BA | 1 |
| Monks, A | 1 |
| Chen, X | 1 |
| Hu, C | 1 |
| Zhang, W | 1 |
| Shen, Y | 1 |
| Hu, F | 1 |
| Yu, P | 1 |
| Kamel, WA | 1 |
| Sugihara, E | 1 |
| Nobusue, H | 1 |
| Yamaguchi-Iwai, S | 1 |
| Onishi, N | 1 |
| Maki, K | 1 |
| Fukuchi, Y | 1 |
| Matsuo, K | 1 |
| Muto, A | 1 |
| Saya, H | 1 |
| Shimizu, T | 1 |
| Nilsson, S | 1 |
| Huelsenbeck, J | 1 |
| Fritz, G | 1 |
| Schurman, L | 1 |
| McCarthy, AD | 1 |
| Sedlinsky, C | 1 |
| Gangoiti, MV | 1 |
| Arnol, V | 1 |
| Bruzzone, L | 1 |
| Cortizo, AM | 1 |
18 other studies available for metformin and Osteogenic Sarcoma
| Article | Year |
|---|---|
Metformin sensitises osteosarcoma to chemotherapy via the IGF-1R/miR-610/FEN1 pathway.
Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytotoxins; Flap Endonucleases; Human | 2023 |
Exploration of Imaging Biomarkers for Metabolically-Targeted Osteosarcoma Therapy in a Murine Xenograft Model.
Topics: Animals; Biomarkers; Bone Neoplasms; Child; Disease Models, Animal; Fluorodeoxyglucose F18; Heterogr | 2023 |
Metformin Suppresses Self-Renewal Ability and Tumorigenicity of Osteosarcoma Stem Cells via Reactive Oxygen Species-Mediated Apoptosis and Autophagy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Bone Neoplasms; Cell Cycle; Cell Proliferation | 2019 |
Metformin induces cell cycle arrest, apoptosis and autophagy through ROS/JNK signaling pathway in human osteosarcoma.
Topics: Animals; Apoptosis; Autophagy; Blotting, Western; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Sur | 2020 |
Metformin increases sensitivity of osteosarcoma stem cells to cisplatin by inhibiting expression of PKM2.
Topics: Adenosine Triphosphate; Apoptosis; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Cisplatin | 2017 |
Therapeutic potential of the metabolic modulator Metformin on osteosarcoma cancer stem-like cells.
Topics: Adenylate Kinase; Adolescent; Antibiotics, Antineoplastic; Bone Neoplasms; Cell Line, Tumor; Cell Pr | 2018 |
Metformin reduces SATB2-mediated osteosarcoma stem cell-like phenotype and tumor growth via inhibition of N-cadherin/NF-kB signaling.
Topics: Adolescent; Animals; Bone Neoplasms; Cadherins; Cell Proliferation; Female; Humans; Male; Matrix Att | 2017 |
In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Pr | 2018 |
Inhibition of LCMR1 and ATG12 by demethylation-activated miR-570-3p is involved in the anti-metastasis effects of metformin on human osteosarcoma.
Topics: Adolescent; Adult; Animals; Autophagy; Autophagy-Related Protein 12; Base Sequence; Cell Line, Tumor | 2018 |
Metformin induces CD11b+-cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and anti-tumor effects.
Topics: Animals; CD11b Antigen; Cell Differentiation; Cell Line, Tumor; Cellular Reprogramming; Cytokines; H | 2019 |
Metformin synergistically enhances antitumor activity of histone deacetylase inhibitor trichostatin a against osteosarcoma cell line.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Apoptosis; Blotting, Western; Bone Neoplasms; Cell Cy | 2013 |
Metformin inhibits growth and sensitizes osteosarcoma cell lines to cisplatin through cell cycle modulation.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols | 2014 |
Metformin as an adjuvant drug against pediatric sarcomas: hypoxia limits therapeutic effects of the drug.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosi | 2013 |
Bioenergetic properties of human sarcoma cells help define sensitivity to metabolic inhibitors.
Topics: Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Respiration; Deoxyglucose; Electron Trans | 2014 |
Metformin inhibits the proliferation, metastasis, and cancer stem-like sphere formation in osteosarcoma MG63 cells in vitro.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell | 2015 |
Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Movement; | 2017 |
Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Bone Neoplasms; Cell Cycle; Cell Proliferation; | 2011 |
Metformin reverts deleterious effects of advanced glycation end-products (AGEs) on osteoblastic cells.
Topics: Animals; Bone Neoplasms; Cell Differentiation; Cell Line; Cell Line, Tumor; Cells, Cultured; Glycati | 2008 |