metformin has been researched along with Neuroblastoma in 11 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "1-1 μM) provides greater antiaging properties than both its high concentration (10 μM) and metformin (2." | 7.88 | Ellagic acid reveals promising anti-aging effects against d-galactose-induced aging on human neuroblastoma cell line, SH-SY5Y: A mechanistic study. ( Askari, VR; Mousavi, SH; Rahimi, VB, 2018) |
| "Metformin has been shown to inhibit tumor growth in xenograft rodent models of adult cancers, and various human clinical trials are in progress." | 5.40 | Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma. ( Al-Sammarraie, N; DiPette, DJ; Kumar, A; Singh, US, 2014) |
| "1-1 μM) provides greater antiaging properties than both its high concentration (10 μM) and metformin (2." | 3.88 | Ellagic acid reveals promising anti-aging effects against d-galactose-induced aging on human neuroblastoma cell line, SH-SY5Y: A mechanistic study. ( Askari, VR; Mousavi, SH; Rahimi, VB, 2018) |
| "Metformin was less effective than MIBG in destabilizing MYC/MYCN." | 1.40 | Destabilization of MYC/MYCN by the mitochondrial inhibitors, metaiodobenzylguanidine, metformin and phenformin. ( Hsiao, R; Ikegaki, N; Limpar, MM; Lomahan, S; Maloney, NJ; Tang, XX; Tran, TA; Wang, SS, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 4 (36.36) | 2.80 |
| Authors | Studies |
|---|---|
| Binlateh, T | 1 |
| Reudhabibadh, R | 1 |
| Prommeenate, P | 1 |
| Hutamekalin, P | 1 |
| Gopar-Cuevas, Y | 1 |
| Saucedo-Cardenas, O | 1 |
| Loera-Arias, MJ | 1 |
| Montes-de-Oca-Luna, R | 1 |
| Rodriguez-Rocha, H | 1 |
| Garcia-Garcia, A | 1 |
| Yang, AJT | 1 |
| Mohammad, A | 1 |
| Finch, MS | 1 |
| Tsiani, E | 1 |
| Spencer, G | 1 |
| Necakov, A | 1 |
| MacPherson, REK | 1 |
| Thapa, S | 1 |
| Abdelaziz, DH | 1 |
| Abdulrahman, BA | 1 |
| Schatzl, HM | 1 |
| Rahimi, VB | 1 |
| Askari, VR | 1 |
| Mousavi, SH | 1 |
| Wang, SS | 1 |
| Hsiao, R | 1 |
| Limpar, MM | 1 |
| Lomahan, S | 1 |
| Tran, TA | 1 |
| Maloney, NJ | 1 |
| Ikegaki, N | 1 |
| Tang, XX | 1 |
| Dulovic, M | 1 |
| Jovanovic, M | 1 |
| Xilouri, M | 1 |
| Stefanis, L | 1 |
| Harhaji-Trajkovic, L | 1 |
| Kravic-Stevovic, T | 1 |
| Paunovic, V | 1 |
| Ardah, MT | 1 |
| El-Agnaf, OM | 1 |
| Kostic, V | 1 |
| Markovic, I | 1 |
| Trajkovic, V | 1 |
| Kumar, A | 1 |
| Al-Sammarraie, N | 1 |
| DiPette, DJ | 1 |
| Singh, US | 1 |
| Son, SM | 1 |
| Shin, HJ | 1 |
| Byun, J | 1 |
| Kook, SY | 1 |
| Moon, M | 1 |
| Chang, YJ | 1 |
| Mook-Jung, I | 1 |
| Garcia-Gil, M | 1 |
| Bertini, F | 1 |
| Pesi, R | 1 |
| Voccoli, V | 1 |
| Tozzi, MG | 1 |
| Camici, M | 1 |
| Cubeddu, LX | 1 |
| Bönisch, H | 1 |
| Göthert, M | 1 |
| Molderings, G | 1 |
| Racké, K | 1 |
| Ramadori, G | 1 |
| Miller, KJ | 1 |
| Schwörer, H | 1 |
11 other studies available for metformin and Neuroblastoma
| Article | Year |
|---|---|
Investigation of mechanisms underlying the inhibitory effects of metformin against proliferation and growth of neuroblastoma SH-SY5Y cells.
Topics: Cell Differentiation; Cell Line, Tumor; Humans; Metformin; Neuroblastoma; Tretinoin | 2022 |
Metformin and Trehalose-Modulated Autophagy Exerts a Neurotherapeutic Effect on Parkinson's Disease.
Topics: Aged; Animals; Autophagy; Dopamine; Humans; Metformin; Mice; Mice, Inbred C57BL; Neuroblastoma; Park | 2023 |
Influence of metabolic stress and metformin on synaptic protein profile in SH-SY5Y-derived neurons.
Topics: Alzheimer Disease; AMP-Activated Protein Kinases; Humans; Insulin; Insulin Resistance; Metformin; Ne | 2023 |
Sephin1 Reduces Prion Infection in Prion-Infected Cells and Animal Model.
Topics: Animals; Cell Line, Tumor; Drug Evaluation, Preclinical; Drug Synergism; Endoplasmic Reticulum Stres | 2020 |
Ellagic acid reveals promising anti-aging effects against d-galactose-induced aging on human neuroblastoma cell line, SH-SY5Y: A mechanistic study.
Topics: Aging; Anilides; beta-Galactosidase; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Ella | 2018 |
Destabilization of MYC/MYCN by the mitochondrial inhibitors, metaiodobenzylguanidine, metformin and phenformin.
Topics: 3-Iodobenzylguanidine; Acetylation; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Prot | 2014 |
The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro.
Topics: alpha-Synuclein; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; AMP-Activated Pro | 2014 |
Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 3; cdc42 GTP-Binding Protein; Cell Death; Cell Li | 2014 |
Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy Activation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2016 |
5 '-Amino-4-imidazolecarboxamide riboside induces apoptosis in human neuroblastoma cells via the mitochondrial pathway.
Topics: Aminoimidazole Carboxamide; Apoptosis; Caspase 9; Cell Line, Tumor; Cell Survival; Cyclic AMP-Depend | 2006 |
Effects of metformin on intestinal 5-hydroxytryptamine (5-HT) release and on 5-HT3 receptors.
Topics: Animals; Binding, Competitive; Cell Membrane; Chromatography, High Pressure Liquid; Duodenum; Entero | 2000 |