metformin has been researched along with Neural Tube Defects in 2 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Neural Tube Defects: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pregnant nondiabetic mice were administered metformin beginning on the first day of pregnancy." | 7.80 | Lack of metformin effect on mouse embryo AMPK activity: implications for metformin treatment during pregnancy. ( Lee, HY; Loeken, MR; Wei, D, 2014) |
| "Pregnant nondiabetic mice were administered metformin beginning on the first day of pregnancy." | 3.80 | Lack of metformin effect on mouse embryo AMPK activity: implications for metformin treatment during pregnancy. ( Lee, HY; Loeken, MR; Wei, D, 2014) |
| "Increasing prevalence of type 2 diabetes in women of childbearing age has led to a higher incidence of diabetes-associated birth defects." | 1.42 | Cellular Stress, Excessive Apoptosis, and the Effect of Metformin in a Mouse Model of Type 2 Diabetic Embryopathy. ( Fu, M; Quon, MJ; Wang, C; Wang, F; Wu, Y; Yang, P, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, HY | 1 |
| Wei, D | 1 |
| Loeken, MR | 1 |
| Wu, Y | 1 |
| Wang, F | 1 |
| Fu, M | 1 |
| Wang, C | 1 |
| Quon, MJ | 1 |
| Yang, P | 1 |
2 other studies available for metformin and Neural Tube Defects
| Article | Year |
|---|---|
Lack of metformin effect on mouse embryo AMPK activity: implications for metformin treatment during pregnancy.
Topics: AMP-Activated Protein Kinases; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes, | 2014 |
Cellular Stress, Excessive Apoptosis, and the Effect of Metformin in a Mouse Model of Type 2 Diabetic Embryopathy.
Topics: Animals; Apoptosis; Caspases; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; End | 2015 |