metformin has been researched along with Nerve Pain in 18 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin is an oral hypoglycemic drug widely used in the management of type 2 diabetes mellitus." | 5.72 | Metformin effect in models of inflammation is associated with activation of ATP-dependent potassium channels and inhibition of tumor necrosis factor-α production. ( Augusto, PSA; Batista, CRA; Bertollo, CM; Braga, AV; Coelho, MM; Costa, SOAM; Dutra, MMGB; Machado, RR; Matsui, TC; Melo, ISF; Morais, MI; Rodrigues, FF, 2022) |
| "Metformin is a prescription drug with a wide range of pharmacological effects, which can augment the anti-cancer efficacy of chemotherapy drugs." | 5.56 | Effect of Metformin Nanoparticle-Mediated Thioredoxin Interacting Protein Expression on Oxaliplatin-Induced Peripheral Neuralgia. ( Liu, Y; Xu, N; Zhou, G, 2020) |
| "Metformin could be considered as an alternative therapeutic agent for SCI, as it potentially attenuates neuroinflammation, sensory and locomotor complications of cord injury." | 3.88 | Anti-inflammatory effects of Metformin improve the neuropathic pain and locomotor activity in spinal cord injured rats: introduction of an alternative therapy. ( Afshari, K; Dehdashtian, A; Dehpour, AR; Ebrahimi, MA; Faghir-Ghanesefat, H; Haddadi, NS; Haj-Mirzaian, A; Iranmehr, A; Javidan, AN; Mohammadi, F; Rahimi, N; Tavangar, SM, 2018) |
| "Metformin is an oral hypoglycemic drug widely used in the management of type 2 diabetes mellitus." | 1.72 | Metformin effect in models of inflammation is associated with activation of ATP-dependent potassium channels and inhibition of tumor necrosis factor-α production. ( Augusto, PSA; Batista, CRA; Bertollo, CM; Braga, AV; Coelho, MM; Costa, SOAM; Dutra, MMGB; Machado, RR; Matsui, TC; Melo, ISF; Morais, MI; Rodrigues, FF, 2022) |
| "Chemotherapy-induced neuropathic pain is a major clinical problem with limited treatment options." | 1.72 | Metformin Relieves Bortezomib-Induced Neuropathic Pain by Regulating AMPKa2-Mediated Autophagy in the Spinal Dorsal Horn. ( Li, D; Lin, SY; Liu, M; Lv, YY; Xin, WJ; Xiong, YC; Xu, T; Zhao, YT, 2022) |
| "In the study of the complex etiology of neuropathic pain (NeP), male and female individuals exhibit quite different responses characterized by higher pain sensitivity and greater NeP incidence in women." | 1.72 | Sex Differences in Neuropathy: The Paradigmatic Case of MetFormin. ( Coccurello, R; De Angelis, F; Giacovazzo, G; Marinelli, S; Pavone, F; Strimpakos, G; Tofanicchio, J; Vacca, V, 2022) |
| "Neuropathic pain is a common complication of diabetes mellitus with poorly relieved by conventional analgesics." | 1.62 | Metformin attenuates diabetic neuropathic pain via AMPK/NF-κB signaling pathway in dorsal root ganglion of diabetic rats. ( Cao, XJ; Chen, X; Qian, HY; Sun, YZ; Wu, R; Xu, GY; Zhang, PA; Zhu, HY, 2021) |
| "Metformin is a prescription drug with a wide range of pharmacological effects, which can augment the anti-cancer efficacy of chemotherapy drugs." | 1.56 | Effect of Metformin Nanoparticle-Mediated Thioredoxin Interacting Protein Expression on Oxaliplatin-Induced Peripheral Neuralgia. ( Liu, Y; Xu, N; Zhou, G, 2020) |
| "Metformin is a widely prescribed drug used in the treatment of type II diabetes." | 1.51 | The antidiabetic drug metformin prevents and reverses neuropathic pain and spinal cord microglial activation in male but not female mice. ( Burton, MD; Dussor, G; Inyang, KE; McDougal, TA; Price, TJ; Szabo-Pardi, T; Wentworth, E, 2019) |
| "Neuropathic pain is a well-known type of chronic pain caused by damage to the nervous system." | 1.51 | Metformin relieves neuropathic pain after spinal nerve ligation via autophagy flux stimulation. ( Poonit, K; Sun, C; Weng, W; Yan, H; Yao, C; Zhang, F; Zhou, X, 2019) |
| "Metformin was administered per os (p." | 1.51 | Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms. ( Augusto, PSA; Batista, CRA; Braga, AV; Coelho, MM; Costa, SOAM; Dutra, MMGB; Goulart, FA; Machado, RR; Melo, ISF; Morais, MI; Rodrigues, FF, 2019) |
| "Metformin is a widely available drug that possesses the ability to activate AMPK." | 1.48 | Effects of metformin on the expression of AMPK and STAT3 in the spinal dorsal horn of rats with neuropathic pain. ( Ge, A; Miao, B; Wang, S; Yan, M, 2018) |
| "Von Frey filaments were used to assess tactile allodynia." | 1.48 | Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain. ( Barragán-Iglesias, P; Delgado-Lezama, R; Granados-Soto, V; Hong, E; Loeza-Alcocer, E; Oidor-Chan, VH; Pineda-Farias, JB; Price, TJ; Salinas-Abarca, AB; Sánchez-Mendoza, A; Velazquez-Lagunas, I, 2018) |
| "Our findings reveal that neuropathic pain-related cognitive impairments in male mice are correlated to bilateral morphological changes in PV interneurons and layer 5/6 IL pyramidal neuron AIS." | 1.48 | Neuropathic Pain Creates an Enduring Prefrontal Cortex Dysfunction Corrected by the Type II Diabetic Drug Metformin But Not by Gabapentin. ( Ahmad, A; Kroener, S; Mejia, G; Mwirigi, J; Pradhan, G; Price, T; Shiers, S, 2018) |
| "In a subset analyses of those with neuropathic pain (n = 156), there were no differences in pain scores found between groups." | 1.42 | Metformin: Potential analgesic? ( Ang, D; Smith, B, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 12 (66.67) | 24.3611 |
| 2020's | 6 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, XJ | 1 |
| Wu, R | 1 |
| Qian, HY | 1 |
| Chen, X | 1 |
| Zhu, HY | 1 |
| Xu, GY | 1 |
| Sun, YZ | 1 |
| Zhang, PA | 1 |
| Augusto, PSA | 2 |
| Matsui, TC | 1 |
| Braga, AV | 2 |
| Rodrigues, FF | 2 |
| Morais, MI | 2 |
| Dutra, MMGB | 2 |
| Batista, CRA | 2 |
| Melo, ISF | 2 |
| Costa, SOAM | 2 |
| Bertollo, CM | 1 |
| Coelho, MM | 2 |
| Machado, RR | 2 |
| Liu, M | 1 |
| Zhao, YT | 1 |
| Lv, YY | 1 |
| Xu, T | 1 |
| Li, D | 1 |
| Xiong, YC | 1 |
| Xin, WJ | 1 |
| Lin, SY | 1 |
| De Angelis, F | 2 |
| Vacca, V | 2 |
| Tofanicchio, J | 2 |
| Strimpakos, G | 2 |
| Giacovazzo, G | 2 |
| Pavone, F | 2 |
| Coccurello, R | 2 |
| Marinelli, S | 2 |
| Liu, Y | 1 |
| Zhou, G | 1 |
| Xu, N | 1 |
| Fu, CN | 1 |
| Wei, H | 1 |
| Gao, WS | 1 |
| Song, SS | 1 |
| Yue, SW | 1 |
| Qu, YJ | 1 |
| Ge, A | 1 |
| Wang, S | 1 |
| Miao, B | 1 |
| Yan, M | 1 |
| Barragán-Iglesias, P | 1 |
| Oidor-Chan, VH | 1 |
| Loeza-Alcocer, E | 1 |
| Pineda-Farias, JB | 1 |
| Velazquez-Lagunas, I | 1 |
| Salinas-Abarca, AB | 1 |
| Hong, E | 1 |
| Sánchez-Mendoza, A | 1 |
| Delgado-Lezama, R | 1 |
| Price, TJ | 3 |
| Granados-Soto, V | 1 |
| Afshari, K | 1 |
| Dehdashtian, A | 1 |
| Haddadi, NS | 1 |
| Haj-Mirzaian, A | 1 |
| Iranmehr, A | 1 |
| Ebrahimi, MA | 1 |
| Tavangar, SM | 1 |
| Faghir-Ghanesefat, H | 1 |
| Mohammadi, F | 1 |
| Rahimi, N | 1 |
| Javidan, AN | 1 |
| Dehpour, AR | 1 |
| Shiers, S | 1 |
| Pradhan, G | 1 |
| Mwirigi, J | 1 |
| Mejia, G | 1 |
| Ahmad, A | 1 |
| Kroener, S | 1 |
| Price, T | 1 |
| Inyang, KE | 1 |
| Szabo-Pardi, T | 1 |
| Wentworth, E | 1 |
| McDougal, TA | 1 |
| Dussor, G | 1 |
| Burton, MD | 1 |
| Weng, W | 1 |
| Yao, C | 1 |
| Poonit, K | 1 |
| Zhou, X | 1 |
| Sun, C | 1 |
| Zhang, F | 1 |
| Yan, H | 1 |
| Dance, A | 1 |
| Goulart, FA | 1 |
| Łabuzek, K | 1 |
| Liber, S | 1 |
| Suchy, D | 1 |
| Okopień, B | 1 |
| Mao-Ying, QL | 1 |
| Kavelaars, A | 1 |
| Krukowski, K | 1 |
| Huo, XJ | 1 |
| Zhou, W | 1 |
| Cleeland, C | 1 |
| Heijnen, CJ | 1 |
| Obara, I | 1 |
| Medrano, MC | 1 |
| Signoret-Genest, J | 1 |
| Jiménez-Díaz, L | 1 |
| Géranton, SM | 1 |
| Hunt, SP | 1 |
| Smith, B | 1 |
| Ang, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Metformin on Chronic Pain After Thoracic Surgery in Diabetic Patients[NCT04089813] | 200 participants (Anticipated) | Observational | 2019-09-10 | Not yet recruiting | |||
| Drug Repurposing for the Prevention of Chemotherapy-induced Peripheral Neuropathy (CIPN)[NCT04780854] | Phase 2 | 68 participants (Anticipated) | Interventional | 2020-11-03 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 other studies available for metformin and Nerve Pain
| Article | Year |
|---|---|
Metformin attenuates diabetic neuropathic pain via AMPK/NF-κB signaling pathway in dorsal root ganglion of diabetic rats.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; | 2021 |
Metformin effect in models of inflammation is associated with activation of ATP-dependent potassium channels and inhibition of tumor necrosis factor-α production.
Topics: Adenosine Triphosphate; Animals; Carrageenan; Diabetes Mellitus, Type 2; Disease Models, Animal; Ede | 2022 |
Metformin Relieves Bortezomib-Induced Neuropathic Pain by Regulating AMPKa2-Mediated Autophagy in the Spinal Dorsal Horn.
Topics: Animals; Autophagy; Beclin-1; Bortezomib; Hyperalgesia; Metformin; Neuralgia; Rats; RNA, Small Inter | 2022 |
Sex Differences in Neuropathy: The Paradigmatic Case of MetFormin.
Topics: AMP-Activated Protein Kinases; Analgesics; Animals; Female; Hyperalgesia; Male; Metformin; Mice; Neu | 2022 |
Sex Differences in Neuropathy: The Paradigmatic Case of MetFormin.
Topics: AMP-Activated Protein Kinases; Analgesics; Animals; Female; Hyperalgesia; Male; Metformin; Mice; Neu | 2022 |
Sex Differences in Neuropathy: The Paradigmatic Case of MetFormin.
Topics: AMP-Activated Protein Kinases; Analgesics; Animals; Female; Hyperalgesia; Male; Metformin; Mice; Neu | 2022 |
Sex Differences in Neuropathy: The Paradigmatic Case of MetFormin.
Topics: AMP-Activated Protein Kinases; Analgesics; Animals; Female; Hyperalgesia; Male; Metformin; Mice; Neu | 2022 |
Effect of Metformin Nanoparticle-Mediated Thioredoxin Interacting Protein Expression on Oxaliplatin-Induced Peripheral Neuralgia.
Topics: Animals; Carrier Proteins; Hyperalgesia; Metformin; Mice; Nanoparticles; Neuralgia; Oxaliplatin; Thi | 2020 |
Obesity increases neuropathic pain via the AMPK-ERK-NOX4 pathway in rats.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Butadienes; Diet, Hig | 2021 |
Effects of metformin on the expression of AMPK and STAT3 in the spinal dorsal horn of rats with neuropathic pain.
Topics: AMP-Activated Protein Kinases; Animals; Astrocytes; Behavior, Animal; Biomarkers; Blood Glucose; Dis | 2018 |
Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain.
Topics: Activating Transcription Factor 3; Amines; Animals; Animals, Newborn; Astrocytes; Cyclohexanecarboxy | 2018 |
Anti-inflammatory effects of Metformin improve the neuropathic pain and locomotor activity in spinal cord injured rats: introduction of an alternative therapy.
Topics: Animals; Central Nervous System Agents; Disease Models, Animal; Hyperalgesia; Inflammation; Locomoti | 2018 |
Neuropathic Pain Creates an Enduring Prefrontal Cortex Dysfunction Corrected by the Type II Diabetic Drug Metformin But Not by Gabapentin.
Topics: Analgesics; Animals; Attention; Axons; Clonidine; Cognition Disorders; Discrimination, Psychological | 2018 |
The antidiabetic drug metformin prevents and reverses neuropathic pain and spinal cord microglial activation in male but not female mice.
Topics: Animals; Cold Temperature; Female; Ganglia, Spinal; Hyperalgesia; Hypoglycemic Agents; Male; Metform | 2019 |
Metformin relieves neuropathic pain after spinal nerve ligation via autophagy flux stimulation.
Topics: Animals; Autophagosomes; Autophagy; Behavior, Animal; Hypoglycemic Agents; Ligation; Male; Metformin | 2019 |
Why the sexes don't feel pain the same way.
Topics: Animals; Hypoglycemic Agents; Male; Metformin; Mice; Neuralgia; Spinal Cord | 2019 |
Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms.
Topics: Analgesics; Animals; Disease Models, Animal; Female; Glyburide; Hyperalgesia; Metformin; Mice; Naltr | 2019 |
A successful case of pain management using metformin in a patient with adiposis dolorosa.
Topics: Adiposis Dolorosa; Cytokines; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Male; Metformi | 2013 |
The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model.
Topics: Animals; Cisplatin; Disease Models, Animal; Hyperalgesia; Hypoglycemic Agents; Metformin; Mice, Inbr | 2014 |
Inhibition of the mammalian target of rapamycin complex 1 signaling pathway reduces itch behaviour in mice.
Topics: Animals; Disease Models, Animal; Gastrin-Releasing Peptide; Histamine; Hypoglycemic Agents; Male; Me | 2015 |
Metformin: Potential analgesic?
Topics: Adolescent; Adult; Aged; Analgesics; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Male; M | 2015 |