metformin has been researched along with Muscular Atrophy in 11 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Muscular Atrophy: Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, prolonged weightlessness, malnutrition, and particularly in denervation.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of the current work was to investigate the effect of metformin versus vitamin D (and also simultaneous administration) therapy in type 2 diabetic (T2D) rats on the state of the muscle and insulin sensitivity." | 7.88 | Synergistic actions of vitamin D and metformin on skeletal muscles and insulin resistance of type 2 diabetic rats. ( Amin, SN; Hassan, SS; Hussein, UK; Rashed, LA; Yassa, HD, 2018) |
| "Metformin (Met) was reported to possess positive effects on preventing muscle damage and promoting muscle mass maintenance." | 5.51 | Beneficial effects of metformin on muscle atrophy induced by obesity in rats. ( Abdelghany, EMA; El-Gendy, J; Hasan, MM; Shalaby, SM, 2019) |
| " Metformin emerges as a choice candidate as it acts both on reducing gluconeogenesis and improving insulin sensitivity, and has demonstrated tumour suppressor properties in multiple cancer types." | 4.90 | Cancer cachexia and diabetes: similarities in metabolic alterations and possible treatment. ( Chevalier, S; Farsijani, S, 2014) |
| " The aim of the current work was to investigate the effect of metformin versus vitamin D (and also simultaneous administration) therapy in type 2 diabetic (T2D) rats on the state of the muscle and insulin sensitivity." | 3.88 | Synergistic actions of vitamin D and metformin on skeletal muscles and insulin resistance of type 2 diabetic rats. ( Amin, SN; Hassan, SS; Hussein, UK; Rashed, LA; Yassa, HD, 2018) |
| "Metformin is an AMPK agonist potentiating insulin actions in the adult human muscle, but not in the aged individuals." | 2.50 | Effects of the antidiabetic drugs on the age-related atrophy and sarcopenia associated with diabetes type II. ( Cetrone, M; Mele, A; Tricarico, D, 2014) |
| "Skeletal muscle atrophy is a severe condition that involves loss of muscle mass and quality." | 1.72 | Metformin induces muscle atrophy by transcriptional regulation of myostatin via HDAC6 and FoxO3a. ( Jung, EJ; Kang, MJ; Kim, HS; Kim, JH; Kim, SJ; Lee, JO; Lee, PR; Moon, JW; Oh, JY; Park, SH; Wu, SW, 2022) |
| "Metformin treatment significantly attenuated muscle catabolism and preserved muscle CSA at the sham size." | 1.56 | Metformin alleviates muscle wasting post-thermal injury by increasing Pax7-positive muscle progenitor cells. ( Amini-Nik, S; Barnes, B; Datu, A; Jeschke, MG; Yousuf, Y, 2020) |
| "Metformin (Met) was reported to possess positive effects on preventing muscle damage and promoting muscle mass maintenance." | 1.51 | Beneficial effects of metformin on muscle atrophy induced by obesity in rats. ( Abdelghany, EMA; El-Gendy, J; Hasan, MM; Shalaby, SM, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 7 (63.64) | 2.80 |
| Authors | Studies |
|---|---|
| Kang, MJ | 1 |
| Moon, JW | 1 |
| Lee, JO | 1 |
| Kim, JH | 1 |
| Jung, EJ | 1 |
| Kim, SJ | 1 |
| Oh, JY | 1 |
| Wu, SW | 1 |
| Lee, PR | 1 |
| Park, SH | 1 |
| Kim, HS | 1 |
| Sharlo, KA | 1 |
| Lvova, ID | 1 |
| Belova, SP | 1 |
| Zaripova, KA | 1 |
| Shenkman, BS | 1 |
| Nemirovskaya, TL | 1 |
| Petrocelli, JJ | 2 |
| de Hart, NMMP | 1 |
| Lang, MJ | 1 |
| Yee, EM | 1 |
| Ferrara, PJ | 2 |
| Fix, DK | 2 |
| Chaix, A | 1 |
| Funai, K | 2 |
| Drummond, MJ | 2 |
| Yousuf, Y | 1 |
| Datu, A | 1 |
| Barnes, B | 1 |
| Amini-Nik, S | 1 |
| Jeschke, MG | 2 |
| Yang, Y | 1 |
| Liao, Z | 1 |
| Xiao, Q | 1 |
| Knuth, CM | 1 |
| Auger, C | 1 |
| Mahmassani, ZS | 1 |
| Montgomery, JA | 1 |
| Reidy, PT | 1 |
| McKenzie, AI | 1 |
| de Hart, NM | 1 |
| Kelley, JJ | 1 |
| Eshima, H | 1 |
| Amin, SN | 1 |
| Hussein, UK | 1 |
| Yassa, HD | 1 |
| Hassan, SS | 1 |
| Rashed, LA | 1 |
| Hasan, MM | 1 |
| Shalaby, SM | 1 |
| El-Gendy, J | 1 |
| Abdelghany, EMA | 1 |
| Chevalier, S | 1 |
| Farsijani, S | 1 |
| Cetrone, M | 1 |
| Mele, A | 1 |
| Tricarico, D | 1 |
3 reviews available for metformin and Muscular Atrophy
| Article | Year |
|---|---|
Burn-induced hypermetabolism and skeletal muscle dysfunction.
Topics: Burns; Cachexia; Epigenesis, Genetic; Exercise; Human Growth Hormone; Humans; Insulin; Metformin; Mu | 2021 |
Cancer cachexia and diabetes: similarities in metabolic alterations and possible treatment.
Topics: Adipose Tissue; Animals; Cachexia; Diabetes Mellitus, Type 2; Energy Metabolism; Glucose; Humans; Hy | 2014 |
Effects of the antidiabetic drugs on the age-related atrophy and sarcopenia associated with diabetes type II.
Topics: Age Factors; Aging; AMP-Activated Protein Kinases; Diabetes Mellitus, Type 2; Humans; Hypoglycemic A | 2014 |
8 other studies available for metformin and Muscular Atrophy
| Article | Year |
|---|---|
Metformin induces muscle atrophy by transcriptional regulation of myostatin via HDAC6 and FoxO3a.
Topics: Animals; Diabetes Mellitus, Type 2; Histone Deacetylase 6; Humans; Metformin; Mice; Mice, Inbred C57 | 2022 |
Metformin Attenuates Slow-to-Fast Fiber Shift and Proteolysis Markers Increase in Rat Soleus after 7 Days of Rat Hindlimb Unloading.
Topics: AMP-Activated Protein Kinases; Animals; Hindlimb Suspension; Male; Metformin; Muscle, Skeletal; Musc | 2022 |
Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail.
Topics: Aged; Animals; Cellular Senescence; Humans; Leucine; Metformin; Mice; Muscle Fibers, Skeletal; Muscl | 2023 |
Metformin alleviates muscle wasting post-thermal injury by increasing Pax7-positive muscle progenitor cells.
Topics: Animals; Burns; Hypoglycemic Agents; Male; Metformin; Mice; Muscle, Skeletal; Muscular Atrophy; PAX7 | 2020 |
Metformin ameliorates skeletal muscle atrophy in Grx1 KO mice by regulating intramuscular lipid accumulation and glucose utilization.
Topics: Animals; Female; Glucose; Glutaredoxins; Lipid Metabolism; Metformin; Mice, Inbred C57BL; Mice, Knoc | 2020 |
Metformin and leucine increase satellite cells and collagen remodeling during disuse and recovery in aged muscle.
Topics: Aging; AMP-Activated Protein Kinases; Animals; Body Weight; Collagen; Fibrosis; Hindlimb Suspension; | 2021 |
Synergistic actions of vitamin D and metformin on skeletal muscles and insulin resistance of type 2 diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Synergism; | 2018 |
Beneficial effects of metformin on muscle atrophy induced by obesity in rats.
Topics: Animals; Diet, High-Fat; Forkhead Box Protein O3; Gene Expression Regulation; Hypoglycemic Agents; M | 2019 |