metformin has been researched along with Muscle Contraction in 14 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin effects were analysed in hypoxia- and monocrotaline-induced PAH in rats." | 5.35 | Protective role of the antidiabetic drug metformin against chronic experimental pulmonary hypertension. ( Agard, C; Dumas-de-La-Roque, E; Loirand, G; Pacaud, P; Rio, M; Rolli-Derkinderen, M; Sagan, C; Savineau, JP, 2009) |
| "The aim of the present study is to determine the effects and molecular mechanisms by which activation of LKB1-AMP-activated protein kinase (AMPK) by metformin regulates vascular smooth muscle contraction." | 3.78 | Metformin-induced AMP-activated protein kinase activation regulates phenylephrine-mediated contraction of rat aorta. ( Choi, HC; Sung, JY, 2012) |
| " Metformin treatment improved the insulin sensitivity, and normalized the in vitro bladder hypercontractility and cystometric dysfunction in obese mice." | 3.78 | Role of PKC and CaV1.2 in detrusor overactivity in a model of obesity associated with insulin resistance in mice. ( Anhê, GF; Antunes, E; Calixto, MC; De Nucci, G; Grant, AD; Leiria, LO; Lintomen, L; Mónica, FZ; Sollon, C; Zanesco, A, 2012) |
| "In this investigation, we compared iLTS scar-derived fibroblasts in patients with and without T2DM." | 1.62 | Characterization of Fibroblasts in Iatrogenic Laryngotracheal Stenosis and Type II Diabetes Mellitus. ( Davis, R; Ding, D; Hillel, AT; Lina, I; Motz, KM; Tsai, HW, 2021) |
| "Metformin effects were analysed in hypoxia- and monocrotaline-induced PAH in rats." | 1.35 | Protective role of the antidiabetic drug metformin against chronic experimental pulmonary hypertension. ( Agard, C; Dumas-de-La-Roque, E; Loirand, G; Pacaud, P; Rio, M; Rolli-Derkinderen, M; Sagan, C; Savineau, JP, 2009) |
| " However, it is also known to accumulate in various tissues up to several times higher after standard oral dosing and we now have evidence from both in vivo and in vitro experiments with spontaneously hypertensive rats (SHR) that millimolar levels stimulate release of norepinephrine (NE) from vascular sympathetic nerve endings (SNEs)." | 1.31 | A possible indirect sympathomimetic action of metformin in the arterial vessel wall of spontanously hypertensive rats. ( Lee, JM; Peuler, JD, 2001) |
| "Metformin treatment of the diabetic rats did not prevent the development of these contractile changes." | 1.30 | The influence of streptozotocin diabetes and metformin on erythrocyte volume and on the membrane potential and the contractile characteristics of the extensor digitorum longus and soleus muscles in rats. ( MacDermott, M; McGuire, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Lina, I | 1 |
| Tsai, HW | 1 |
| Ding, D | 1 |
| Davis, R | 1 |
| Motz, KM | 1 |
| Hillel, AT | 1 |
| Brown, AE | 1 |
| Dibnah, B | 1 |
| Fisher, E | 1 |
| Newton, JL | 1 |
| Walker, M | 1 |
| Miyamoto, L | 1 |
| Learsi, SK | 1 |
| Bastos-Silva, VJ | 1 |
| Lima-Silva, AE | 1 |
| Bertuzzi, R | 1 |
| De Araujo, GG | 1 |
| Agard, C | 1 |
| Rolli-Derkinderen, M | 1 |
| Dumas-de-La-Roque, E | 1 |
| Rio, M | 1 |
| Sagan, C | 1 |
| Savineau, JP | 1 |
| Loirand, G | 1 |
| Pacaud, P | 1 |
| Sung, JY | 1 |
| Choi, HC | 1 |
| Wang, Z | 1 |
| Cheng, Z | 1 |
| Cristofaro, V | 1 |
| Li, J | 1 |
| Xiao, X | 1 |
| Gomez, P | 1 |
| Ge, R | 1 |
| Gong, E | 1 |
| Strle, K | 1 |
| Sullivan, MP | 1 |
| Adam, RM | 1 |
| White, MF | 1 |
| Olumi, AF | 1 |
| Leiria, LO | 1 |
| Sollon, C | 1 |
| Calixto, MC | 1 |
| Lintomen, L | 1 |
| Mónica, FZ | 1 |
| Anhê, GF | 1 |
| De Nucci, G | 1 |
| Zanesco, A | 1 |
| Grant, AD | 1 |
| Antunes, E | 1 |
| Iida, KT | 1 |
| Kawakami, Y | 1 |
| Suzuki, M | 1 |
| Shimano, H | 1 |
| Toyoshima, H | 1 |
| Sone, H | 1 |
| Shimada, K | 1 |
| Iwama, Y | 1 |
| Watanabe, Y | 1 |
| Mokuno, H | 1 |
| Kamata, K | 1 |
| Yamada, N | 1 |
| Musi, N | 1 |
| Goodyear, LJ | 1 |
| Peuler, JD | 3 |
| Miller, JA | 1 |
| Bourghli, M | 1 |
| Zammam, HY | 1 |
| Soltis, EE | 1 |
| Sowers, JR | 1 |
| McGuire, M | 1 |
| MacDermott, M | 1 |
| Lee, JM | 2 |
| Smith, JM | 1 |
2 reviews available for metformin and Muscle Contraction
| Article | Year |
|---|---|
[AMPK as a Metabolic Intersection between Diet and Physical Exercise].
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Biphenyl Compounds; Diet; Drug Discovery; | 2018 |
AMP-activated protein kinase and muscle glucose uptake.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Exercise; Glucose; Glycogen; Hum | 2003 |
1 trial available for metformin and Muscle Contraction
| Article | Year |
|---|---|
Metformin improves performance in high-intensity exercise, but not anaerobic capacity in healthy male subjects.
Topics: Adenosine Triphosphate; Anaerobiosis; Energy Metabolism; Exercise; Glycolysis; Healthy Volunteers; H | 2015 |
11 other studies available for metformin and Muscle Contraction
| Article | Year |
|---|---|
Characterization of Fibroblasts in Iatrogenic Laryngotracheal Stenosis and Type II Diabetes Mellitus.
Topics: Adult; Aged; Amobarbital; Biopsy; Case-Control Studies; Cell Proliferation; Cells, Cultured; Cicatri | 2021 |
Pharmacological activation of AMPK and glucose uptake in cultured human skeletal muscle cells from patients with ME/CFS.
Topics: Adult; AMP-Activated Protein Kinase Kinases; Biopsy; Carbohydrate Metabolism; Cell Culture Technique | 2018 |
Protective role of the antidiabetic drug metformin against chronic experimental pulmonary hypertension.
Topics: Animals; Cell Proliferation; Chronic Disease; Endothelium, Vascular; Enzyme Activation; Hemodynamics | 2009 |
Metformin-induced AMP-activated protein kinase activation regulates phenylephrine-mediated contraction of rat aorta.
Topics: Actins; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Aorta; Blood P | 2012 |
Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Insulin Receptor Substrate Proteins; Met | 2012 |
Role of PKC and CaV1.2 in detrusor overactivity in a model of obesity associated with insulin resistance in mice.
Topics: Adiposity; Amlodipine; Animals; Body Weight; Calcium Channel Blockers; Calcium Channels, L-Type; Cal | 2012 |
Effect of thiazolidinediones and metformin on LDL oxidation and aortic endothelium relaxation in diabetic GK rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arteriosclerosis; Cholesterol, LDL; Chromans; Diabetes Mell | 2003 |
Disparate effects of antidiabetic drugs on arterial contraction.
Topics: Animals; Arteries; Blood Pressure; Glyburide; Humans; Hypoglycemic Agents; In Vitro Techniques; Insu | 1997 |
The influence of streptozotocin diabetes and metformin on erythrocyte volume and on the membrane potential and the contractile characteristics of the extensor digitorum longus and soleus muscles in rats.
Topics: Animals; Diabetes Mellitus, Experimental; Erythrocyte Volume; Hematologic Tests; Hypoglycemic Agents | 1999 |
4-Aminopyridine antagonizes the acute relaxant action of metformin on adrenergic contraction in the ventral tail artery of the rat.
Topics: 4-Aminopyridine; Animals; Arteries; Dose-Response Relationship, Drug; Female; Hypoglycemic Agents; I | 1999 |
A possible indirect sympathomimetic action of metformin in the arterial vessel wall of spontanously hypertensive rats.
Topics: Animals; Antidepressive Agents; Arteries; Autonomic Fibers, Postganglionic; Desipramine; Drug Intera | 2001 |