metformin has been researched along with Multiple Myeloma in 27 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Metformin has a certain effect on anti-thrombosis, but its role and mechanism in MM-induced thrombosis are still uncovered." | 8.12 | Metformin Inhibits Multiple Myeloma Serum-induced Endothelial Cell Thrombosis by Down-Regulating miR-532. ( Dai, X; De, Z; Gao, L; Hu, J; Li, G; Li, L; Xu, F; Zhang, Y, 2022) |
| "To investigate the effects of metformin on proliferation and apoptosis in multiple myeloma cell line RPMI8226 and U266, and to clarify the molecular mechanism of proliferation inhibition and apoptosis induced by metformin." | 7.85 | [Effect of Metformin on Proliferation of Multiple Myeloma Cells]. ( Gui, SY; Liu, ZL; Lu, B; Zhou, HH, 2017) |
| "FDA-approved ritonavir and metformin effectively target multiple myeloma cell metabolism to elicit cytotoxicity in multiple myeloma." | 7.81 | Targeting the metabolic plasticity of multiple myeloma with FDA-approved ritonavir and metformin. ( Adekola, KU; Bajpai, R; Dalva-Aydemir, S; Kandela, I; Koblinski, JE; Martinez, M; Raje, NS; Rosen, ST; Shanmugam, M; Singhal, S; Wei, C, 2015) |
| " We defined metformin users as patients with diabetes who were given metformin consistently for 4 years after their diabetes diagnosis and before multiple myeloma development, death, or censorship." | 7.81 | Association between metformin use and progression of monoclonal gammopathy of undetermined significance to multiple myeloma in US veterans with diabetes mellitus: a population-based retrospective cohort study. ( Carlsson, NP; Carson, KR; Chang, SH; Colditz, GA; Luo, S; O'Brian, KK; Thomas, TS, 2015) |
| "Metformin has begun to be discussed as a potentially useful agent on the basis of the results of epidemiological and preclinical research showing that it may be beneficial in patients with leukaemia, lymphomas and multiple myeloma." | 5.72 | Reduced Progression of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma in Type 2 Diabetes Mellitus: Will Metformin Never Stop Its Pleasant Surprises? ( Papachristou, S; Papanas, N; Popovic, DS, 2022) |
| "Metformin is a widely prescribed antidiabetic drug with direct antitumor activity against various tumor cell lines." | 5.48 | Metformin and FTY720 Synergistically Induce Apoptosis in Multiple Myeloma Cells. ( Cai, Z; Deng, G; He, J; Liu, X; Lv, N; Ma, L; Wu, W; Yan, M; Yao, S; Yu, R; Zhang, E; Zhao, Y; Zi, F, 2018) |
| " An association between metabolic syndrome, inflammatory cytokinesand incidence of MM has been also described, while the use of metformin and statins has been identified as a positive prognostic factor for the disease course." | 5.12 | Metabolic Disorders in Multiple Myeloma. ( Dimopoulos, MA; Gavriatopoulou, M; Ntanasis-Stathopoulos, I; Paschou, SA, 2021) |
| " She has a history of chronic hypertension treated with a diuretic, adult-onset diabetes mellitus treated with metformin, and hypothyroidism treated with levothyroxine." | 4.98 | Treatment approach for the older, unfit patient with myeloma from diagnosis to relapse: perspectives of a European hematologist. ( Anderson, K; Facon, T, 2018) |
| " She has a history of chronic hypertension treated with a diuretic, adult-onset diabetes mellitus treated with metformin, and hypothyroidism treated with levothyroxine." | 4.98 | Approach to the treatment of the older, unfit patient with myeloma from diagnosis to relapse: perspectives of a US hematologist and a geriatric hematologist. ( Anderson, KC; Wildes, TM, 2018) |
| " In a recent issue of this journal, Van der Vreken, Oudaert I and colleagues showed that syrosingopine, together with another drug metformin, had a synergistic effect in killing cultured multiple myeloma (MM) cell lines, primary MM blasts from patients, and in a mouse MM model." | 4.31 | An acid test for metformin ( Benjamin, D, 2023) |
| " Metformin has a certain effect on anti-thrombosis, but its role and mechanism in MM-induced thrombosis are still uncovered." | 4.12 | Metformin Inhibits Multiple Myeloma Serum-induced Endothelial Cell Thrombosis by Down-Regulating miR-532. ( Dai, X; De, Z; Gao, L; Hu, J; Li, G; Li, L; Xu, F; Zhang, Y, 2022) |
| "To investigate the effects of metformin on proliferation and apoptosis in multiple myeloma cell line RPMI8226 and U266, and to clarify the molecular mechanism of proliferation inhibition and apoptosis induced by metformin." | 3.85 | [Effect of Metformin on Proliferation of Multiple Myeloma Cells]. ( Gui, SY; Liu, ZL; Lu, B; Zhou, HH, 2017) |
| "FDA-approved ritonavir and metformin effectively target multiple myeloma cell metabolism to elicit cytotoxicity in multiple myeloma." | 3.81 | Targeting the metabolic plasticity of multiple myeloma with FDA-approved ritonavir and metformin. ( Adekola, KU; Bajpai, R; Dalva-Aydemir, S; Kandela, I; Koblinski, JE; Martinez, M; Raje, NS; Rosen, ST; Shanmugam, M; Singhal, S; Wei, C, 2015) |
| "Despite the clinical benefit of the proteasome inhibitor bortezomib, multiple myeloma (MM) patients invariably relapse through poorly defined mechanisms." | 3.81 | Molecular chaperone GRP78 enhances aggresome delivery to autophagosomes to promote drug resistance in multiple myeloma. ( Abd El-Azeem, HG; Abdel Malek, MA; Driscoll, JJ; Elgammal, SA; Jagannathan, S; Malek, E; Sayed, DM; Thabet, NM, 2015) |
| " We defined metformin users as patients with diabetes who were given metformin consistently for 4 years after their diabetes diagnosis and before multiple myeloma development, death, or censorship." | 3.81 | Association between metformin use and progression of monoclonal gammopathy of undetermined significance to multiple myeloma in US veterans with diabetes mellitus: a population-based retrospective cohort study. ( Carlsson, NP; Carson, KR; Chang, SH; Colditz, GA; Luo, S; O'Brian, KK; Thomas, TS, 2015) |
| "Metformin also plays an important role in the treatment of hematologic tumors, especially in leukemia, lymphoma, and multiple myeloma (MM)." | 3.01 | Repurposing Metformin in hematologic tumor: State of art. ( Chen, Y; Hu, M; Jing, L; Ma, T, 2023) |
| "Metformin has begun to be discussed as a potentially useful agent on the basis of the results of epidemiological and preclinical research showing that it may be beneficial in patients with leukaemia, lymphomas and multiple myeloma." | 1.72 | Reduced Progression of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma in Type 2 Diabetes Mellitus: Will Metformin Never Stop Its Pleasant Surprises? ( Papachristou, S; Papanas, N; Popovic, DS, 2022) |
| "Metformin is a commonly used drug for the treatment of diabetes." | 1.48 | Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways. ( Li, J; Mi, J; Wang, Y; Xu, W; Yan, H; Yan, Z; Zhao, W, 2018) |
| "Metformin is a widely prescribed antidiabetic drug with direct antitumor activity against various tumor cell lines." | 1.48 | Metformin and FTY720 Synergistically Induce Apoptosis in Multiple Myeloma Cells. ( Cai, Z; Deng, G; He, J; Liu, X; Lv, N; Ma, L; Wu, W; Yan, M; Yao, S; Yu, R; Zhang, E; Zhao, Y; Zi, F, 2018) |
| "Metformin is a widely prescribed antidiabetic drug." | 1.42 | Metformin displays anti-myeloma activity and synergistic effect with dexamethasone in in vitro and in vivo xenograft models. ( Cai, Z; Han, XY; He, DH; He, JS; Huang, H; Li, Y; Wang, LJ; Wu, C; Wu, WJ; Yang, L; Yang, Y; Yi, Q; Zhao, Y; Zheng, GF; Zi, FM, 2015) |
| "Metformin co-treatment with bortezomib suppressed induction of the critical UPR effector glucose-regulated protein 78 (GRP78) to impair autophagosome formation and enhance apoptosis." | 1.42 | Pharmacologic screens reveal metformin that suppresses GRP78-dependent autophagy to enhance the anti-myeloma effect of bortezomib. ( Abdel-Malek, MA; Anderson, KC; Driscoll, JJ; Jagannathan, S; Latif, T; Malek, E; Vad, N, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 15 (55.56) | 24.3611 |
| 2020's | 12 (44.44) | 2.80 |
| Authors | Studies |
|---|---|
| Gavriatopoulou, M | 2 |
| Paschou, SA | 1 |
| Ntanasis-Stathopoulos, I | 2 |
| Dimopoulos, MA | 1 |
| Papachristou, S | 1 |
| Popovic, DS | 1 |
| Papanas, N | 1 |
| Tentolouris, A | 1 |
| Eleftheriadou, I | 1 |
| Malandrakis, P | 1 |
| Tzeravini, E | 1 |
| Gao, L | 1 |
| Li, L | 1 |
| Hu, J | 3 |
| Li, G | 2 |
| Zhang, Y | 5 |
| Dai, X | 1 |
| De, Z | 1 |
| Xu, F | 1 |
| Zhuang, J | 1 |
| Zu, J | 1 |
| Zhou, C | 1 |
| Sun, Y | 2 |
| Kong, P | 1 |
| Jing, Y | 1 |
| Chen, CJ | 1 |
| Huang, JY | 1 |
| Huang, JQ | 1 |
| Deng, JY | 1 |
| Shangguan, XH | 1 |
| Chen, AZ | 1 |
| Chen, LT | 1 |
| Wu, WH | 1 |
| Van der Vreken, A | 1 |
| Oudaert, I | 1 |
| Ates, G | 1 |
| Faict, S | 1 |
| Vlummens, P | 1 |
| Satilmis, H | 1 |
| Fan, R | 1 |
| Maes, A | 1 |
| Massie, A | 1 |
| De Veirman, K | 1 |
| De Bruyne, E | 1 |
| Vanderkerken, K | 1 |
| Menu, E | 1 |
| Benjamin, D | 1 |
| Hu, M | 1 |
| Chen, Y | 4 |
| Ma, T | 1 |
| Jing, L | 1 |
| Nathwani, N | 1 |
| Palmer, J | 1 |
| Synold, TW | 1 |
| Salehian, B | 1 |
| Rosenzweig, M | 1 |
| Sanchez, JF | 1 |
| Hammond, SN | 1 |
| Adekola, K | 1 |
| Tomarchio, V | 1 |
| Chowdhury, A | 1 |
| Karanes, C | 1 |
| Htut, M | 1 |
| Sahebi, F | 1 |
| Siddiqi, T | 1 |
| Krishnan, A | 1 |
| Forman, SJ | 1 |
| Rosen, ST | 2 |
| Kocemba-Pilarczyk, KA | 1 |
| Trojan, S | 1 |
| Ostrowska, B | 1 |
| Lasota, M | 1 |
| Dudzik, P | 1 |
| Kusior, D | 1 |
| Kot, M | 1 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 4 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
| Buan, MEM | 1 |
| Flox, C | 1 |
| Chavan, S | 1 |
| Shi, X | 1 |
| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
| Tammeveski, K | 1 |
| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
| Veziroglu, E | 1 |
| Iranzo, A | 1 |
| M Kannan, A | 1 |
| Arunamata, A | 1 |
| Tacy, TA | 1 |
| Kache, S | 1 |
| Mainwaring, RD | 1 |
| Ma, M | 1 |
| Maeda, K | 1 |
| Punn, R | 1 |
| Noguchi, S | 1 |
| Hahn, S | 3 |
| Iwasa, Y | 3 |
| Ling, J | 2 |
| Voccio, JP | 2 |
| Kim, Y | 3 |
| Song, J | 3 |
| Bascuñán, J | 2 |
| Chu, Y | 1 |
| Tomita, M | 1 |
| Cazorla, M | 1 |
| Herrera, E | 1 |
| Palomeque, E | 1 |
| Saud, N | 1 |
| Hoplock, LB | 1 |
| Lobchuk, MM | 1 |
| Lemoine, J | 1 |
| Li, X | 10 |
| Henson, MA | 1 |
| Unsihuay, D | 1 |
| Qiu, J | 1 |
| Swaroop, S | 1 |
| Nagornov, KO | 1 |
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| Tsybin, YO | 1 |
| Kuang, S | 1 |
| Laskin, J | 1 |
| Zin, NNINM | 1 |
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| Roslan, K | 1 |
| Abdul Wafi, S | 1 |
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| Alias, A | 1 |
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| Abu-Bakar, N | 1 |
| Naveed, A | 1 |
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| Siddique, AB | 1 |
| Akbar, M | 1 |
| Riaz, M | 1 |
| Mushtaq, Z | 1 |
| Sikandar, M | 1 |
| Ilyas, S | 1 |
| Bibi, I | 1 |
| Asghar, A | 1 |
| Rasool, G | 1 |
| Irfan, M | 1 |
| Li, XY | 1 |
| Zhao, S | 1 |
| Fan, XH | 1 |
| Chen, KP | 1 |
| Hua, W | 1 |
| Liu, ZM | 1 |
| Xue, XD | 1 |
| Zhou, B | 1 |
| Zhang, S | 2 |
| Xing, YL | 1 |
| Chen, MA | 1 |
| Neradilek, MB | 1 |
| Wu, XT | 1 |
| Zhang, D | 2 |
| Huang, W | 1 |
| Cui, Y | 1 |
| Yang, QQ | 1 |
| Li, HW | 1 |
| Zhao, XQ | 1 |
| Hossein Rashidi, B | 1 |
| Tarafdari, A | 1 |
| Ghazimirsaeed, ST | 1 |
| Shahrokh Tehraninezhad, E | 1 |
| Keikha, F | 1 |
| Eslami, B | 1 |
| Ghazimirsaeed, SM | 1 |
| Jafarabadi, M | 1 |
| Silvani, Y | 1 |
| Lovita, AND | 1 |
| Maharani, A | 1 |
| Wiyasa, IWA | 1 |
| Sujuti, H | 1 |
| Ratnawati, R | 1 |
| Raras, TYM | 1 |
| Lemin, AS | 1 |
| Rahman, MM | 1 |
| Pangarah, CA | 1 |
| Kiyu, A | 1 |
| Zeng, C | 2 |
| Du, H | 1 |
| Lin, D | 1 |
| Jalan, D | 1 |
| Rubagumya, F | 1 |
| Hopman, WM | 1 |
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| Lopes, G | 1 |
| Seruga, B | 1 |
| Booth, CM | 1 |
| Berry, S | 1 |
| Hammad, N | 1 |
| Sajo, EA | 1 |
| Okunade, KS | 1 |
| Olorunfemi, G | 1 |
| Rabiu, KA | 1 |
| Anorlu, RI | 1 |
| Xu, C | 2 |
| Xiang, Y | 1 |
| Xu, X | 1 |
| Zhou, L | 2 |
| Dong, X | 1 |
| Tang, S | 1 |
| Gao, XC | 1 |
| Wei, CH | 1 |
| Zhang, RG | 1 |
| Cai, Q | 1 |
| He, Y | 1 |
| Tong, F | 1 |
| Dong, JH | 1 |
| Wu, G | 1 |
| Dong, XR | 1 |
| Tang, X | 1 |
| Tao, F | 1 |
| Xiang, W | 1 |
| Zhao, Y | 5 |
| Jin, L | 1 |
| Tao, H | 1 |
| Lei, Y | 1 |
| Gan, H | 1 |
| Huang, Y | 1 |
| Chen, L | 3 |
| Shan, A | 1 |
| Zhao, H | 2 |
| Wu, M | 2 |
| Ma, Q | 1 |
| Wang, J | 4 |
| Zhang, E | 3 |
| Zhang, J | 3 |
| Li, Y | 6 |
| Xue, F | 1 |
| Deng, L | 1 |
| Liu, L | 2 |
| Yan, Z | 3 |
| Wang, Y | 3 |
| Meng, J | 1 |
| Chen, G | 2 |
| Anastassiadou, M | 1 |
| Bernasconi, G | 1 |
| Brancato, A | 1 |
| Carrasco Cabrera, L | 1 |
| Greco, L | 1 |
| Jarrah, S | 1 |
| Kazocina, A | 1 |
| Leuschner, R | 1 |
| Magrans, JO | 1 |
| Miron, I | 1 |
| Nave, S | 1 |
| Pedersen, R | 1 |
| Reich, H | 1 |
| Rojas, A | 1 |
| Sacchi, A | 1 |
| Santos, M | 1 |
| Theobald, A | 1 |
| Vagenende, B | 1 |
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| Du, L | 1 |
| Liu, X | 3 |
| Ren, Y | 1 |
| Li, J | 8 |
| Li, P | 1 |
| Jiao, Q | 1 |
| Meng, P | 1 |
| Wang, F | 2 |
| Wang, YS | 1 |
| Wang, C | 3 |
| Zhou, X | 2 |
| Wang, W | 1 |
| Wang, S | 2 |
| Hou, J | 1 |
| Zhang, A | 1 |
| Lv, B | 1 |
| Gao, C | 1 |
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| Lu, K | 1 |
| Ahmad, NH | 1 |
| Wang, L | 1 |
| Zhu, J | 2 |
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| Zhuang, T | 1 |
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| Yao, H | 1 |
| Wang, X | 5 |
| Lee, DF | 1 |
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| Chung, DH | 1 |
| Paeng, JC | 1 |
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| Kang, KW | 1 |
| Lee, DS | 1 |
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| Yi, Q | 1 |
| Dalva-Aydemir, S | 1 |
| Bajpai, R | 1 |
| Martinez, M | 1 |
| Adekola, KU | 1 |
| Kandela, I | 1 |
| Wei, C | 1 |
| Singhal, S | 1 |
| Koblinski, JE | 1 |
| Raje, NS | 1 |
| Shanmugam, M | 1 |
| Abdel Malek, MA | 1 |
| Jagannathan, S | 2 |
| Malek, E | 2 |
| Sayed, DM | 1 |
| Elgammal, SA | 1 |
| Abd El-Azeem, HG | 1 |
| Thabet, NM | 1 |
| Driscoll, JJ | 2 |
| Chang, SH | 1 |
| Luo, S | 1 |
| O'Brian, KK | 1 |
| Thomas, TS | 1 |
| Colditz, GA | 1 |
| Carlsson, NP | 1 |
| Carson, KR | 1 |
| Abdel-Malek, MA | 1 |
| Vad, N | 1 |
| Latif, T | 1 |
| Hanson, DJ | 1 |
| Nakamura, S | 1 |
| Amachi, R | 1 |
| Hiasa, M | 1 |
| Oda, A | 1 |
| Tsuji, D | 1 |
| Itoh, K | 1 |
| Harada, T | 1 |
| Horikawa, K | 1 |
| Teramachi, J | 1 |
| Miki, H | 1 |
| Matsumoto, T | 1 |
| Abe, M | 1 |
| Boursi, B | 1 |
| Mamtani, R | 1 |
| Yang, YX | 1 |
| Weiss, BM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Trial, Open Label, Clinical Activity of Metformin in Combination With High-dose of Dexamethasone (HDdexa) in Patients With Relapsed/Refractory Multiple Myeloma[NCT02967276] | Phase 2 | 28 participants (Anticipated) | Interventional | 2017-01-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for metformin and Multiple Myeloma
| Article | Year |
|---|---|
Metabolic Disorders in Multiple Myeloma.
Topics: Cell Proliferation; Cytokines; Energy Metabolism; Glycolysis; Humans; Metabolic Diseases; Metabolic | 2021 |
Diabetes mellitus and multiple myeloma; common features of two distinct entities.
Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Multiple Myeloma; Pioglitazone | 2022 |
Repurposing Metformin in hematologic tumor: State of art.
Topics: Animals; Diabetes Mellitus, Type 2; Drug Repositioning; Hematologic Neoplasms; Humans; Metformin; Mu | 2023 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Treatment approach for the older, unfit patient with myeloma from diagnosis to relapse: perspectives of a European hematologist.
Topics: Aged; Diabetes Mellitus; Female; Fractures, Compression; Humans; Hypertension; Kidney Diseases; Metf | 2018 |
Approach to the treatment of the older, unfit patient with myeloma from diagnosis to relapse: perspectives of a US hematologist and a geriatric hematologist.
Topics: Aged; Diabetes Mellitus; Female; Fractures, Compression; Health Services for the Aged; Humans; Hyper | 2018 |
1 trial available for metformin and Multiple Myeloma
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
21 other studies available for metformin and Multiple Myeloma
| Article | Year |
|---|---|
Reduced Progression of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma in Type 2 Diabetes Mellitus: Will Metformin Never Stop Its Pleasant Surprises?
Topics: Diabetes Mellitus, Type 2; Disease Progression; Humans; Metformin; Monoclonal Gammopathy of Undeterm | 2022 |
Metformin Inhibits Multiple Myeloma Serum-induced Endothelial Cell Thrombosis by Down-Regulating miR-532.
Topics: Cells, Cultured; Endothelial Protein C Receptor; Fibrinolytic Agents; Human Umbilical Vein Endotheli | 2022 |
Bioinformatic Data Mining for Candidate Drugs Affecting Risk of Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) in Cancer Patients.
Topics: Androgen Antagonists; Androgens; Aspirin; Bisphosphonate-Associated Osteonecrosis of the Jaw; Caspas | 2022 |
Metformin attenuates multiple myeloma cell proliferation and encourages apoptosis by suppressing METTL3-mediated m6A methylation of THRAP3, RBM25, and USP4.
Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Apoptosis; Cell Proliferation; DNA-Binding Proteins; | 2023 |
Metformin confers sensitisation to syrosingopine in multiple myeloma cells by metabolic blockage and inhibition of protein synthesis.
Topics: Antineoplastic Agents; Cell Line, Tumor; Humans; Lactic Acid; Metformin; Monocarboxylic Acid Transpo | 2023 |
An acid test for metformin
Topics: Animals; Carrier Proteins; Cell Line, Tumor; Glycolysis; Hypoglycemic Agents; Lactic Acid; Metformin | 2023 |
Toxicities Associated With Metformin/Ritonavir Combination Treatment in Relapsed/Refractory Multiple Myeloma.
Topics: Combined Modality Therapy; Female; Humans; Metformin; Middle Aged; Multiple Myeloma; Pilot Projects; | 2020 |
Influence of metformin on HIF-1 pathway in multiple myeloma.
Topics: Apoptosis; Cell Hypoxia; Cell Line, Tumor; Humans; Hypoxia-Inducible Factor 1; Metformin; Multiple M | 2020 |
[Effect of Metformin on Proliferation of Multiple Myeloma Cells].
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Metformin; Multiple Myeloma | 2017 |
Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; | 2018 |
Metformin and FTY720 Synergistically Induce Apoptosis in Multiple Myeloma Cells.
Topics: Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Endoplasmic Reticulum St | 2018 |
Metformin inhibits IL-6 signaling by decreasing IL-6R expression on multiple myeloma cells.
Topics: Antibodies, Monoclonal; Biomarkers, Tumor; Bortezomib; Cell Line, Tumor; Dexamethasone; Enzyme-Linke | 2019 |
The synergistic effect of PFK15 with metformin exerts anti-myeloma activity via PFKFB3.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; | 2019 |
The association of diabetes and anti-diabetic medications with clinical outcomes in multiple myeloma.
Topics: Adult; Aged; Aged, 80 and over; Comorbidity; Diabetes Mellitus, Type 2; Disease Progression; Female; | 2014 |
Metformin displays anti-myeloma activity and synergistic effect with dexamethasone in in vitro and in vivo xenograft models.
Topics: Animals; Antineoplastic Agents, Hormonal; Apoptosis; Blotting, Western; Cell Cycle; Cell Proliferati | 2015 |
Targeting the metabolic plasticity of multiple myeloma with FDA-approved ritonavir and metformin.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Disease | 2015 |
Molecular chaperone GRP78 enhances aggresome delivery to autophagosomes to promote drug resistance in multiple myeloma.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Bortezomib; Cell L | 2015 |
Association between metformin use and progression of monoclonal gammopathy of undetermined significance to multiple myeloma in US veterans with diabetes mellitus: a population-based retrospective cohort study.
Topics: Aged; Diabetes Mellitus; Female; Humans; Male; Metformin; Middle Aged; Monoclonal Gammopathy of Unde | 2015 |
Pharmacologic screens reveal metformin that suppresses GRP78-dependent autophagy to enhance the anti-myeloma effect of bortezomib.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Bortezomib; Cell Line, Tumor; Drug Synergism; | 2015 |
Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation.
Topics: Cell Death; Cell Line, Tumor; Coumaric Acids; Gene Knockdown Techniques; Humans; Hydrogen-Ion Concen | 2015 |
Impact of metformin on the progression of MGUS to multiple myeloma.
Topics: Antineoplastic Agents; Case-Control Studies; Disease Progression; Humans; Incidence; Metformin; Mono | 2017 |