metformin has been researched along with Morbid Obesity in 32 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Adolescents (aged 12-18 years) with obesity, insulin resistance (IR), and a family history of type 2 diabetes mellitus (T2DM) will receive either metformin (850 mg p." | 9.41 | Efficacy of metformin and fermentable fiber combination therapy in adolescents with severe obesity and insulin resistance: study protocol for a double-blind randomized controlled trial. ( Ball, GDC; Colin-Ramirez, E; Deehan, EC; Dinu, I; Field, CJ; Freemark, M; Haqq, AM; Madsen, KL; Newgard, CB; Orsso, C; Pakseresht, M; Prado, CM; Rubin, D; Sharma, AM; Tan, Q; Triador, L; Tun, H; Walter, J; Wine, E, 2021) |
| " The use of dapagliflozin in this population could improve weight loss and other cardiovascular factors." | 9.34 | Efficacy of the treatment with dapagliflozin and metformin compared to metformin monotherapy for weight loss in patients with class III obesity: a randomized controlled trial. ( Espinosa, E; Ferreira-Hermosillo, A; Garrido-Mendoza, AP; Mendoza-Zubieta, V; Mercado, M; Molina-Ayala, MA; Molina-Guerrero, D; Ramírez-Rentería, C, 2020) |
| "To describe the composition of jejunal microbiota in morbidly obese patients, as well as its link with insulin resistance and metformin treatment." | 7.96 | Mucosa-associated microbiota in the jejunum of patients with morbid obesity: alterations in states of insulin resistance and metformin treatment. ( García-Fuentes, E; Gonzalo, M; Gutiérrez-Repiso, C; Ho-Plágaro, A; Martín-Núñez, GM; Moreno-Indias, I; Rodríguez-Cañete, A; Tinahones, FJ, 2020) |
| "Pharmacokinetic data suggest that the risk of metformin-associated lactic acidosis (MALA) may be increased after Roux-en-Y gastric bypass (RYGB) surgery." | 7.88 | Risk of Metformin-Associated Lactic Acidosis (MALA) in Patients After Gastric Bypass Surgery. ( Aarts, EO; Aelfers, SCW; Berends, FJ; de Boer, H; Deden, LN; Janssen, IMC; van Borren, MMGJ, 2018) |
| " We conducted a pilot, open-label study of response to metformin in 21 children with PWS and six with early morbid obesity (EMO)." | 7.80 | Effects of metformin in children and adolescents with Prader-Willi syndrome and early-onset morbid obesity: a pilot study. ( Dykens, EM; Linville, TD; Miller, JL, 2014) |
| " Adolescents (aged 12-18 years) with obesity, insulin resistance (IR), and a family history of type 2 diabetes mellitus (T2DM) will receive either metformin (850 mg p." | 5.41 | Efficacy of metformin and fermentable fiber combination therapy in adolescents with severe obesity and insulin resistance: study protocol for a double-blind randomized controlled trial. ( Ball, GDC; Colin-Ramirez, E; Deehan, EC; Dinu, I; Field, CJ; Freemark, M; Haqq, AM; Madsen, KL; Newgard, CB; Orsso, C; Pakseresht, M; Prado, CM; Rubin, D; Sharma, AM; Tan, Q; Triador, L; Tun, H; Walter, J; Wine, E, 2021) |
| " The use of dapagliflozin in this population could improve weight loss and other cardiovascular factors." | 5.34 | Efficacy of the treatment with dapagliflozin and metformin compared to metformin monotherapy for weight loss in patients with class III obesity: a randomized controlled trial. ( Espinosa, E; Ferreira-Hermosillo, A; Garrido-Mendoza, AP; Mendoza-Zubieta, V; Mercado, M; Molina-Ayala, MA; Molina-Guerrero, D; Ramírez-Rentería, C, 2020) |
| "Our study shows that in severely obese, non-diabetic, hyperinsulinaemic patients undergoing a nutritional programme, rosiglitazone is more effective than metformin in producing favourable changes in fasting-based indexes of glucose metabolism, with a reduction of both insulin resistance and hyperinsulinaemia." | 5.13 | Rosiglitazone is more effective than metformin in improving fasting indexes of glucose metabolism in severely obese, non-diabetic patients. ( Brunani, A; Castagna, G; Caumo, A; Graci, S; Liuzzi, A; Viberti, G, 2008) |
| "The aim of this study was to assess the effects of orlistat on weight loss-related clinical variables in overweight/obese women with polycystic ovary syndrome (PCOS) and to compare treatment with orlistat vs." | 4.93 | Effects of orlistat vs. metformin on weight loss-related clinical variables in women with PCOS: systematic review and meta-analysis. ( Graff, SK; Mario, FM; Spritzer, PM; Ziegelmann, P, 2016) |
| " We aim to study the profile of duodenal cytokines and chemokines in patients with morbid obesity (MO), its relation with insulin resistance (IR) and the intake of metformin, and with the evolution of MO after sleeve gastrectomy (SG)." | 3.96 | A lower duodenal immune response is associated with an increase of insulin resistance in patients with morbid obesity. ( Alcaín-Martínez, G; Escamilla, A; Garcia-Fuentes, E; Garcia-Muñoz, B; García-Serrano, S; Garrido-Sanchez, L; Gonzalo, M; Ho-Plagaro, A; Montiel-Casado, C; Rodriguez, C; Ruiz-Santana, N; Santiago-Fernandez, C; Vázquez-Pedreño, L, 2020) |
| "To describe the composition of jejunal microbiota in morbidly obese patients, as well as its link with insulin resistance and metformin treatment." | 3.96 | Mucosa-associated microbiota in the jejunum of patients with morbid obesity: alterations in states of insulin resistance and metformin treatment. ( García-Fuentes, E; Gonzalo, M; Gutiérrez-Repiso, C; Ho-Plágaro, A; Martín-Núñez, GM; Moreno-Indias, I; Rodríguez-Cañete, A; Tinahones, FJ, 2020) |
| "Pharmacokinetic data suggest that the risk of metformin-associated lactic acidosis (MALA) may be increased after Roux-en-Y gastric bypass (RYGB) surgery." | 3.88 | Risk of Metformin-Associated Lactic Acidosis (MALA) in Patients After Gastric Bypass Surgery. ( Aarts, EO; Aelfers, SCW; Berends, FJ; de Boer, H; Deden, LN; Janssen, IMC; van Borren, MMGJ, 2018) |
| " We conducted a pilot, open-label study of response to metformin in 21 children with PWS and six with early morbid obesity (EMO)." | 3.80 | Effects of metformin in children and adolescents with Prader-Willi syndrome and early-onset morbid obesity: a pilot study. ( Dykens, EM; Linville, TD; Miller, JL, 2014) |
| "One year of diet control with lifestyle modifications and pharmacological treatment with glucagon-like peptide-1 receptor agonists and metformin markedly decreased hemoglobin A1c levels and resulted in effective and substantial weight loss in a morbidly obese patient with dysregulated diabetes during the preoperative period." | 3.80 | Effective weight loss after treatment with a glucagon-like peptide-1 receptor agonist in a morbidly obese and diabetic patient before bariatric surgery: a case report. ( Chen, JH; Lee, CH; Tang, WH, 2014) |
| "After GB, weight loss was 21 +/- 14." | 2.71 | Metabolic and psychosocial effects of minimal invasive gastric banding for morbid obesity. ( Dittmar, M; Egle, UT; Hardt, J; Heintz, A; Kahaly, GJ, 2003) |
| "Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and comprises a liver disease spectrum ranging from steatosis to nonalcoholic steatohepatitis (NASH) with risk of progression to liver cirrhosis and hepatocellular carcinoma (HCC)." | 2.52 | Challenges and Management of Liver Cirrhosis: Practical Issues in the Therapy of Patients with Cirrhosis due to NAFLD and NASH. ( Halilbasic, E; Hofer, H; Kazemi-Shirazi, L; Kienbacher, C; Munda, P; Rechling, C; Trauner, M; Traussnigg, S, 2015) |
| "Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized cause of liver disease worldwide." | 2.47 | Nonalcoholic fatty liver disease and type 2 diabetes mellitus: the hidden epidemic. ( Ismail, MH, 2011) |
| "Childhood and adolescent obesity has become a global epidemic." | 1.91 | [Research progresses on interventions of obesity in children and adolescents]. ( Wan, NJ; Zhang, T, 2023) |
| " Here, an adult physiologically based pharmacokinetic (PBPK) model of metformin was scaled to pediatric populations without obesity, with overweight/obesity, and with severe obesity; a published virtual population of children and adolescents with obesity was leveraged during model evaluation." | 1.72 | Physiologically Based Pharmacokinetic Modeling of Metformin in Children and Adolescents With Obesity. ( Edginton, AN; Ford, JL; Gerhart, JG; Gonzalez, D; Hon, YY; Yanovski, JA, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (25.00) | 29.6817 |
| 2010's | 16 (50.00) | 24.3611 |
| 2020's | 8 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ford, JL | 1 |
| Gerhart, JG | 1 |
| Edginton, AN | 1 |
| Yanovski, JA | 1 |
| Hon, YY | 1 |
| Gonzalez, D | 2 |
| Wan, NJ | 1 |
| Zhang, T | 3 |
| Ho-Plagaro, A | 2 |
| Santiago-Fernandez, C | 2 |
| García-Serrano, S | 2 |
| Rodriguez, C | 1 |
| Garrido-Sanchez, L | 2 |
| Escamilla, A | 1 |
| Gonzalo, M | 2 |
| Montiel-Casado, C | 1 |
| Alcaín-Martínez, G | 1 |
| Garcia-Muñoz, B | 1 |
| Ruiz-Santana, N | 1 |
| Vázquez-Pedreño, L | 1 |
| Garcia-Fuentes, E | 3 |
| Ferreira-Hermosillo, A | 1 |
| Molina-Ayala, MA | 1 |
| Molina-Guerrero, D | 1 |
| Garrido-Mendoza, AP | 1 |
| Ramírez-Rentería, C | 1 |
| Mendoza-Zubieta, V | 1 |
| Espinosa, E | 1 |
| Mercado, M | 1 |
| Gutiérrez-Repiso, C | 1 |
| Moreno-Indias, I | 1 |
| Martín-Núñez, GM | 1 |
| Rodríguez-Cañete, A | 1 |
| Tinahones, FJ | 3 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 4 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
| Buan, MEM | 1 |
| Flox, C | 1 |
| Chavan, S | 1 |
| Shi, X | 1 |
| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
| Tammeveski, K | 1 |
| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
| Veziroglu, E | 1 |
| Iranzo, A | 1 |
| M Kannan, A | 1 |
| Arunamata, A | 1 |
| Tacy, TA | 1 |
| Kache, S | 1 |
| Mainwaring, RD | 1 |
| Ma, M | 1 |
| Maeda, K | 1 |
| Punn, R | 1 |
| Noguchi, S | 1 |
| Hahn, S | 3 |
| Iwasa, Y | 3 |
| Ling, J | 2 |
| Voccio, JP | 2 |
| Kim, Y | 3 |
| Song, J | 3 |
| Bascuñán, J | 2 |
| Chu, Y | 1 |
| Tomita, M | 1 |
| Cazorla, M | 1 |
| Herrera, E | 1 |
| Palomeque, E | 1 |
| Saud, N | 1 |
| Hoplock, LB | 1 |
| Lobchuk, MM | 1 |
| Lemoine, J | 1 |
| Li, X | 10 |
| Henson, MA | 1 |
| Unsihuay, D | 1 |
| Qiu, J | 1 |
| Swaroop, S | 1 |
| Nagornov, KO | 1 |
| Kozhinov, AN | 1 |
| Tsybin, YO | 1 |
| Kuang, S | 1 |
| Laskin, J | 1 |
| Zin, NNINM | 1 |
| Mohamad, MN | 1 |
| Roslan, K | 1 |
| Abdul Wafi, S | 1 |
| Abdul Moin, NI | 1 |
| Alias, A | 1 |
| Zakaria, Y | 1 |
| Abu-Bakar, N | 1 |
| Naveed, A | 1 |
| Jilani, K | 1 |
| Siddique, AB | 1 |
| Akbar, M | 1 |
| Riaz, M | 1 |
| Mushtaq, Z | 1 |
| Sikandar, M | 1 |
| Ilyas, S | 1 |
| Bibi, I | 1 |
| Asghar, A | 1 |
| Rasool, G | 1 |
| Irfan, M | 1 |
| Li, XY | 1 |
| Zhao, S | 1 |
| Fan, XH | 1 |
| Chen, KP | 1 |
| Hua, W | 1 |
| Liu, ZM | 1 |
| Xue, XD | 1 |
| Zhou, B | 1 |
| Zhang, S | 2 |
| Xing, YL | 1 |
| Chen, MA | 1 |
| Sun, Y | 1 |
| Neradilek, MB | 1 |
| Wu, XT | 1 |
| Zhang, D | 2 |
| Huang, W | 1 |
| Cui, Y | 1 |
| Yang, QQ | 1 |
| Li, HW | 1 |
| Zhao, XQ | 1 |
| Hossein Rashidi, B | 1 |
| Tarafdari, A | 1 |
| Ghazimirsaeed, ST | 1 |
| Shahrokh Tehraninezhad, E | 1 |
| Keikha, F | 1 |
| Eslami, B | 1 |
| Ghazimirsaeed, SM | 1 |
| Jafarabadi, M | 1 |
| Silvani, Y | 1 |
| Lovita, AND | 1 |
| Maharani, A | 1 |
| Wiyasa, IWA | 1 |
| Sujuti, H | 1 |
| Ratnawati, R | 1 |
| Raras, TYM | 1 |
| Lemin, AS | 1 |
| Rahman, MM | 1 |
| Pangarah, CA | 1 |
| Kiyu, A | 1 |
| Zeng, C | 2 |
| Du, H | 1 |
| Lin, D | 1 |
| Jalan, D | 1 |
| Rubagumya, F | 1 |
| Hopman, WM | 1 |
| Vanderpuye, V | 1 |
| Lopes, G | 1 |
| Seruga, B | 1 |
| Booth, CM | 1 |
| Berry, S | 1 |
| Hammad, N | 1 |
| Sajo, EA | 1 |
| Okunade, KS | 1 |
| Olorunfemi, G | 1 |
| Rabiu, KA | 1 |
| Anorlu, RI | 1 |
| Xu, C | 2 |
| Xiang, Y | 1 |
| Xu, X | 1 |
| Zhou, L | 2 |
| Dong, X | 1 |
| Tang, S | 1 |
| Gao, XC | 1 |
| Wei, CH | 1 |
| Zhang, RG | 1 |
| Cai, Q | 1 |
| He, Y | 1 |
| Tong, F | 1 |
| Dong, JH | 1 |
| Wu, G | 1 |
| Dong, XR | 1 |
| Tang, X | 1 |
| Tao, F | 1 |
| Xiang, W | 1 |
| Zhao, Y | 2 |
| Jin, L | 1 |
| Tao, H | 1 |
| Lei, Y | 1 |
| Gan, H | 1 |
| Huang, Y | 1 |
| Chen, Y | 3 |
| Chen, L | 3 |
| Shan, A | 1 |
| Zhao, H | 2 |
| Wu, M | 2 |
| Ma, Q | 1 |
| Wang, J | 4 |
| Zhang, E | 1 |
| Zhang, J | 3 |
| Li, Y | 5 |
| Xue, F | 1 |
| Deng, L | 1 |
| Liu, L | 2 |
| Yan, Z | 2 |
| Wang, Y | 2 |
| Meng, J | 1 |
| Chen, G | 2 |
| Anastassiadou, M | 1 |
| Bernasconi, G | 1 |
| Brancato, A | 1 |
| Carrasco Cabrera, L | 1 |
| Greco, L | 1 |
| Jarrah, S | 1 |
| Kazocina, A | 1 |
| Leuschner, R | 1 |
| Magrans, JO | 1 |
| Miron, I | 1 |
| Nave, S | 1 |
| Pedersen, R | 1 |
| Reich, H | 1 |
| Rojas, A | 1 |
| Sacchi, A | 1 |
| Santos, M | 1 |
| Theobald, A | 1 |
| Vagenende, B | 1 |
| Verani, A | 1 |
| Du, L | 1 |
| Liu, X | 1 |
| Ren, Y | 1 |
| Li, J | 7 |
| Li, P | 1 |
| Jiao, Q | 1 |
| Meng, P | 1 |
| Wang, F | 2 |
| Wang, YS | 1 |
| Wang, C | 3 |
| Zhou, X | 2 |
| Wang, W | 1 |
| Wang, S | 2 |
| Hou, J | 1 |
| Zhang, A | 1 |
| Lv, B | 1 |
| Gao, C | 1 |
| Pang, D | 1 |
| Lu, K | 1 |
| Ahmad, NH | 1 |
| Wang, L | 1 |
| Zhu, J | 2 |
| Zhang, L | 2 |
| Zhuang, T | 1 |
| Tu, J | 1 |
| Zhao, Z | 1 |
| Qu, Y | 1 |
| Yao, H | 1 |
| Wang, X | 5 |
| Lee, DF | 1 |
| Shen, J | 3 |
| Wen, L | 1 |
| Huang, G | 2 |
| Xie, X | 1 |
| Zhao, Q | 1 |
| Hu, W | 1 |
| Zhang, Y | 4 |
| Wu, X | 1 |
| Lu, J | 2 |
| Li, M | 1 |
| Li, W | 2 |
| Wu, W | 1 |
| Du, F | 1 |
| Ji, H | 1 |
| Yang, X | 2 |
| Xu, Z | 1 |
| Wan, L | 1 |
| Wen, Q | 1 |
| Cho, CH | 1 |
| Zou, C | 1 |
| Xiao, Z | 1 |
| Liao, J | 1 |
| Su, X | 1 |
| Bi, Z | 1 |
| Su, Q | 1 |
| Huang, H | 1 |
| Wei, Y | 2 |
| Gao, Y | 2 |
| Na, KJ | 1 |
| Choi, H | 1 |
| Oh, HR | 1 |
| Kim, YH | 1 |
| Lee, SB | 1 |
| Jung, YJ | 1 |
| Koh, J | 1 |
| Park, S | 1 |
| Lee, HJ | 1 |
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| Chung, DH | 1 |
| Paeng, JC | 1 |
| Park, IK | 1 |
| Kang, CH | 1 |
| Cheon, GJ | 1 |
| Kang, KW | 1 |
| Lee, DS | 1 |
| Kim, YT | 1 |
| Pajuelo-Lozano, N | 1 |
| Alcalá, S | 1 |
| Sainz, B | 1 |
| Perona, R | 1 |
| Sanchez-Perez, I | 1 |
| Logotheti, S | 1 |
| Marquardt, S | 1 |
| Gupta, SK | 1 |
| Richter, C | 1 |
| Edelhäuser, BAH | 1 |
| Engelmann, D | 1 |
| Brenmoehl, J | 1 |
| Söhnchen, C | 1 |
| Murr, N | 1 |
| Alpers, M | 1 |
| Singh, KP | 1 |
| Wolkenhauer, O | 1 |
| Heckl, D | 1 |
| Spitschak, A | 1 |
| Pützer, BM | 1 |
| Liao, Y | 1 |
| Cheng, J | 1 |
| Kong, X | 1 |
| Li, S | 1 |
| Zhang, M | 4 |
| Zhang, H | 1 |
| Yang, T | 2 |
| Dong, Y | 1 |
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| Yuan, Z | 1 |
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| Mei, Z | 1 |
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| Liu, Z | 2 |
| Liang, C | 1 |
| Yang, H | 1 |
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| Yu, K | 1 |
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| Huang, Z | 1 |
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| Ge, J | 1 |
| Hu, J | 2 |
| Wang, H | 2 |
| Liu, Y | 4 |
| Mi, Y | 1 |
| Kong, H | 1 |
| Xi, D | 1 |
| Yan, W | 1 |
| Luo, X | 1 |
| Ning, Q | 1 |
| Chang, X | 2 |
| Wang, Q | 2 |
| Rathore, MG | 1 |
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| Shin, SH | 1 |
| Ma, WY | 1 |
| Bode, AM | 1 |
| Dong, Z | 1 |
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| Liu, C | 3 |
| Gao, F | 1 |
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| Zhang, X | 4 |
| Cai, X | 1 |
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| Chen, W | 2 |
| Hu, X | 1 |
| Zhang, F | 1 |
| Wei, H | 1 |
| Wang, Z | 1 |
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| Jung, I | 1 |
| Sugimura, H | 2 |
| Stefan-van Staden, RI | 1 |
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| Iwashita, Y | 1 |
| Szodorai, R | 1 |
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| Solis Condor, R | 1 |
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| Spritzer, PM | 1 |
| Tomé, M | 1 |
| Umpaichitra, V | 1 |
| Cyganek, K | 1 |
| Koblik, T | 1 |
| Kozek, E | 1 |
| Wojcik, M | 1 |
| Starzyk, J | 1 |
| Malecki, MT | 1 |
| Ismail, MH | 1 |
| Ait-Omar, A | 1 |
| Monteiro-Sepulveda, M | 1 |
| Poitou, C | 1 |
| Le Gall, M | 1 |
| Cotillard, A | 1 |
| Gilet, J | 1 |
| Garbin, K | 1 |
| Houllier, A | 1 |
| Château, D | 1 |
| Lacombe, A | 1 |
| Veyrie, N | 1 |
| Hugol, D | 1 |
| Tordjman, J | 1 |
| Magnan, C | 1 |
| Serradas, P | 1 |
| Clément, K | 1 |
| Leturque, A | 1 |
| Brot-Laroche, E | 1 |
| Benetti, A | 1 |
| Garbossa, SG | 1 |
| Veronelli, A | 1 |
| Pontiroli, AE | 1 |
| Dittmar, M | 1 |
| Heintz, A | 1 |
| Hardt, J | 1 |
| Egle, UT | 1 |
| Kahaly, GJ | 1 |
| Podgorski, GP | 1 |
| Chiasson, JL | 1 |
| Hoppin, AG | 1 |
| Katz, ES | 1 |
| Kaplan, LM | 1 |
| Lauwers, GY | 1 |
| Brunani, A | 1 |
| Caumo, A | 1 |
| Graci, S | 1 |
| Castagna, G | 1 |
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| Liuzzi, A | 1 |
| Aylwin, S | 1 |
| Al-Zaman, Y | 1 |
| Kay, JP | 1 |
| Alemzadeh, R | 1 |
| Langley, G | 1 |
| D'Angelo, L | 1 |
| Smith, P | 1 |
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| Sattar, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effectiveness of the Treatment With Dapagliflozin and Metformin Compared to Metformin Monotherapy for Weight Loss on Diabetic and Prediabetic Patients With Obesity Class III[NCT03968224] | Phase 2/Phase 3 | 90 participants (Anticipated) | Interventional | 2018-07-07 | Recruiting | ||
| Fiber Supplementation and Metformin Combination Therapy in Adolescents With Severe Obesity and Insulin Resistance: Interactions With the Gut Microbiome.[NCT04578652] | Phase 3 | 90 participants (Anticipated) | Interventional | 2021-10-22 | Recruiting | ||
| Open, Randomized, Unicenter Study Comparing Metabolic Surgery With Intensive Medical Therapy to Treat Diabetic Kidney Disease[NCT04626323] | Phase 2 | 60 participants (Anticipated) | Interventional | 2021-05-25 | Recruiting | ||
| Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Research Project[NCT00474318] | 250 participants (Actual) | Observational | 2007-03-31 | Active, not recruiting | |||
| Studies to Treat Or Prevent Pediatric Type 2 Diabetes (STOPP-T2D) Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Clinical Trial[NCT00081328] | Phase 3 | 699 participants (Actual) | Interventional | 2004-05-31 | Completed | ||
| [NCT01542242] | Phase 4 | 1 participants (Actual) | Interventional | 2012-02-29 | Terminated (stopped due to Subject withdrew) | ||
| Metformin as Adjunctive Therapy in Overweight and Obese Patients With Dengue: an Open-label Safety and Tolerability Trial[NCT04377451] | Phase 1/Phase 2 | 120 participants (Actual) | Interventional | 2020-07-27 | Completed | ||
| Inflammatory Mediators in Obese Adolescents With Insulin Resistance Following Metformin Treatment: Controlled Randomized Clinical Trial[NCT01410604] | Phase 4 | 31 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| Effects of Inositol Alone or Associated With Alpha-lipoic Acid in Polycystic Ovary Syndrome Treatment[NCT04881851] | 90 participants (Anticipated) | Interventional | 2015-05-07 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Body mass index (BMI) measured in kg per meters squared. The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. (NCT00081328)
Timeframe: 24 months
| Intervention | kg per meters squared (Mean) |
|---|---|
| 1 Metformin Alone | 36.7 |
| 2 Metformin + Rosliglitazone | 38.2 |
| 3 Metformin + Lifestyle Program | 35.3 |
Measured by DXA, both whole body scan and AP-spine scan. The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. In addition, in about 1/3 of participants DXA scans could not be obtained on participants weighing more than 300 pounds (136 kg), the upper limit in size set by the machine manufacturers. Scans were considered invalid if a body part (e.g., arm, leg) was completely off or partially off the scanner, there was hand-hip overlap, or there was motion or movement during the scan. (NCT00081328)
Timeframe: 24 months
| Intervention | g/cm squared (Mean) |
|---|---|
| 1 Metformin Alone | 1.15 |
| 2 Metformin + Rosliglitazone | 1.15 |
| 3 Metformin + Lifestyle Program | 1.15 |
Determined by DXA whole body scan. The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. In addition, in about 1/3 of participants DXA scans could not be obtained on participants weighing more than 300 pounds (136 kg), the upper limit in size set by the machine manufacturers. Scans were considered invalid if a body part (e.g., arm, leg) was completely off or partially off the scanner, there was hand-hip overlap, or there was motion or movement during the scan. (NCT00081328)
Timeframe: 24 months
| Intervention | kg (Mean) |
|---|---|
| 1 Metformin Alone | 36.1 |
| 2 Metformin + Rosliglitazone | 39.7 |
| 3 Metformin + Lifestyle Program | 32.2 |
Waist circumference (cm) measured at the iliac crest at its outermost point with the measuring tape placed around the participant in a horizontal plane parallel to the floor at the mark and the measurement teken at the end of normal expiration without the tape compressing the skin. The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. (NCT00081328)
Timeframe: 24 months
| Intervention | cm (Mean) |
|---|---|
| 1 Metformin Alone | 110.8 |
| 2 Metformin + Rosliglitazone | 114.0 |
| 3 Metformin + Lifestyle Program | 108.6 |
A diagnosis was made by an out-of-range value >=95th percentile or systolic >=130 or diastolic >=80 sustained over 6 months or on an anti-hypertensive medication. (NCT00081328)
Timeframe: Data collected at baseline and during follow-up - 2 years to 6.5 years from randomization.
| Intervention | participants (Number) |
|---|---|
| 1 Metformin Alone | 57 |
| 2 Metformin + Rosliglitazone | 53 |
| 3 Metformin + Lifestyle Program | 45 |
A diagnosis was made from out-of-range value >= 130 mg/dL sustained over 6 months or put on lipid lowering medication. (NCT00081328)
Timeframe: Data collected at baseline and during follow-up - 2 years to 6.5 years from randomization.
| Intervention | participants (Number) |
|---|---|
| 1 Metformin Alone | 18 |
| 2 Metformin + Rosliglitazone | 16 |
| 3 Metformin + Lifestyle Program | 15 |
A diagnosis was made by an out-of-range value >=150 mg/dL sustained over 6 months or on appropriate lipid lowering medication. (NCT00081328)
Timeframe: Data collected at baseline and during follow-up - 2 years to 6.5 years from randomization.
| Intervention | participants (Number) |
|---|---|
| 1 Metformin Alone | 20 |
| 2 Metformin + Rosliglitazone | 28 |
| 3 Metformin + Lifestyle Program | 22 |
Insulinogenic index determined from OGTT as difference in insulin at 30 minutes minus 0 minutes divided by difference in glucose at 30 minutes minus 0 minutes. The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. (NCT00081328)
Timeframe: 24 months
| Intervention | uU/mL divided by mg/dL (Median) |
|---|---|
| 1 Metformin Alone | .75 |
| 2 Metformin + Rosliglitazone | .83 |
| 3 Metformin + Lifestyle Program | .71 |
All participants were followed to 24 months. Insulin sensitivity is measured from OGTT as inverse of fasting insulin (mL/uU). The analysis sample includes only participants with 24 month data who had not experienced the primary outcome by that time. (NCT00081328)
Timeframe: 24 months
| Intervention | mL/uU (Median) |
|---|---|
| 1 Metformin Alone | 0.037 |
| 2 Metformin + Rosiglitazone | 0.049 |
| 3 Metformin + Lifestyle Program | 0.039 |
Number of serious adverse events reported during the trial. Participant could have multiple episodes reported. (NCT00081328)
Timeframe: Reported as occurred during study follow-up - 2 years to 6.5 years from randomization.
| Intervention | episodes of serious adverse event (Number) |
|---|---|
| 1 Metformin Alone | 42 |
| 2 Metformin + Rosiglitazone | 34 |
| 3 Metformin + Lifestyle Program | 58 |
Defined as A1c persistently >=8% over a 6-month period or persistent metabolic decompensation (inability to wean insulin within 3 months of initiation or the occurrence of a second episode within three months of discontinuing insulin) (NCT00081328)
Timeframe: Study duration - 2 years to 6.5 years of follow up from randomization
| Intervention | participants (Number) | |
|---|---|---|
| Treatment failure | Did not fail treatment during trial | |
| 1 Metformin Alone | 120 | 112 |
| 2 Metformin + Rosliglitazone | 90 | 143 |
| 3 Metformin + Lifestyle Program | 109 | 125 |
Change from baseline in Adiponectin after 3 months of treatment. (NCT01410604)
Timeframe: baseline and 3 months
| Intervention | µg/mL (Mean) |
|---|---|
| Metformin | -0.71 |
| Placebo | -7.52 |
Change from baseline in Body Mass Index after 3 months of treatment. (NCT01410604)
Timeframe: baseline and 3 months
| Intervention | kg/m^2 (Mean) |
|---|---|
| Metformin | -0.74 |
| Placebo | -0.71 |
Change from baseline in Fasting insulin after 3 months of treatment. (NCT01410604)
Timeframe: baseline and 3 months
| Intervention | µU/mL (Mean) |
|---|---|
| Metformin | -3.97 |
| Placebo | 11.03 |
Change from baseline in Fasting plasma glucose after 3 months of treatment. (NCT01410604)
Timeframe: baseline and 3 months
| Intervention | mg/dL (Mean) |
|---|---|
| Metformin | -1.08 |
| Placebo | 1.71 |
Change from baseline in High-sensitivity C-reactive protein after 3 months of treatment. (NCT01410604)
Timeframe: baseline and 3 months
| Intervention | mg/dL (Mean) |
|---|---|
| Metformin | -1.26 |
| Placebo | -1.35 |
Change from baseline in Interleukin 6 after 3 months of treatment. (NCT01410604)
Timeframe: baseline and 3 months
| Intervention | pg/mL (Mean) |
|---|---|
| Metformin | -34.09 |
| Placebo | 16.42 |
Change from baseline in Tumour necrosis factor alpha after 3 months of treatment. (NCT01410604)
Timeframe: baseline and 3 months
| Intervention | pg/mL (Mean) |
|---|---|
| Metformin | -34.08 |
| Placebo | -4.01 |
Change from baseline in Waist circumference after 3 months of treatment. (NCT01410604)
Timeframe: baseline and 3 months
| Intervention | cm (Mean) |
|---|---|
| Metformin | -0.57 |
| Placebo | -3.29 |
6 reviews available for metformin and Morbid Obesity
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Challenges and Management of Liver Cirrhosis: Practical Issues in the Therapy of Patients with Cirrhosis due to NAFLD and NASH.
Topics: Anticholesteremic Agents; Antioxidants; Bariatric Surgery; Carcinoma, Hepatocellular; Disease Progre | 2015 |
Effects of orlistat vs. metformin on weight loss-related clinical variables in women with PCOS: systematic review and meta-analysis.
Topics: Anti-Obesity Agents; Female; Humans; Lactones; Metformin; Obesity, Morbid; Orlistat; Polycystic Ovar | 2016 |
Nonalcoholic fatty liver disease and type 2 diabetes mellitus: the hidden epidemic.
Topics: Bariatric Surgery; Biopsy; Diabetes Mellitus, Type 2; Disease Progression; Exercise; Fatty Liver; Hu | 2011 |
Pharmacological and surgical intervention for the prevention of diabetes.
Topics: Acarbose; Bariatric Surgery; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Life Style; Met | 2006 |
Emerging concepts in the medical and surgical treatment of obesity.
Topics: Adipose Tissue; Amyloid; Anticonvulsants; Antidepressive Agents; Anxiety; Appetite Regulation; Baria | 2008 |
9 trials available for metformin and Morbid Obesity
| Article | Year |
|---|---|
Efficacy of the treatment with dapagliflozin and metformin compared to metformin monotherapy for weight loss in patients with class III obesity: a randomized controlled trial.
Topics: Adult; Benzhydryl Compounds; Clinical Trials, Phase IV as Topic; Diabetes Mellitus, Type 2; Dose-Res | 2020 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Efficacy of metformin and fermentable fiber combination therapy in adolescents with severe obesity and insulin resistance: study protocol for a double-blind randomized controlled trial.
Topics: Adolescent; Diabetes Mellitus, Type 2; Double-Blind Method; Humans; Hypoglycemic Agents; Insulin Res | 2021 |
Comparison of Surgical and Medical Therapy for Type 2 Diabetes in Severely Obese Adolescents.
Topics: Adolescent; Anthropometry; Bariatric Surgery; Blood Glucose; Body Mass Index; Child; Diabetes Mellit | 2018 |
Comparison of Surgical and Medical Therapy for Type 2 Diabetes in Severely Obese Adolescents.
Topics: Adolescent; Anthropometry; Bariatric Surgery; Blood Glucose; Body Mass Index; Child; Diabetes Mellit | 2018 |
Comparison of Surgical and Medical Therapy for Type 2 Diabetes in Severely Obese Adolescents.
Topics: Adolescent; Anthropometry; Bariatric Surgery; Blood Glucose; Body Mass Index; Child; Diabetes Mellit | 2018 |
Comparison of Surgical and Medical Therapy for Type 2 Diabetes in Severely Obese Adolescents.
Topics: Adolescent; Anthropometry; Bariatric Surgery; Blood Glucose; Body Mass Index; Child; Diabetes Mellit | 2018 |
Comparison of Surgical and Medical Therapy for Type 2 Diabetes in Severely Obese Adolescents.
Topics: Adolescent; Anthropometry; Bariatric Surgery; Blood Glucose; Body Mass Index; Child; Diabetes Mellit | 2018 |
Comparison of Surgical and Medical Therapy for Type 2 Diabetes in Severely Obese Adolescents.
Topics: Adolescent; Anthropometry; Bariatric Surgery; Blood Glucose; Body Mass Index; Child; Diabetes Mellit | 2018 |
Comparison of Surgical and Medical Therapy for Type 2 Diabetes in Severely Obese Adolescents.
Topics: Adolescent; Anthropometry; Bariatric Surgery; Blood Glucose; Body Mass Index; Child; Diabetes Mellit | 2018 |
Comparison of Surgical and Medical Therapy for Type 2 Diabetes in Severely Obese Adolescents.
Topics: Adolescent; Anthropometry; Bariatric Surgery; Blood Glucose; Body Mass Index; Child; Diabetes Mellit | 2018 |
Comparison of Surgical and Medical Therapy for Type 2 Diabetes in Severely Obese Adolescents.
Topics: Adolescent; Anthropometry; Bariatric Surgery; Blood Glucose; Body Mass Index; Child; Diabetes Mellit | 2018 |
[Metformin has no effect on median birth weight score in pregnant non-diabetic women with BMI >35].
Topics: Adult; Birth Weight; Body Mass Index; Diabetes, Gestational; Double-Blind Method; Female; Humans; In | 2016 |
Metabolic and psychosocial effects of minimal invasive gastric banding for morbid obesity.
Topics: Activities of Daily Living; Adult; Anthropometry; Body Composition; Cholesterol; Digestive System Su | 2003 |
Rosiglitazone is more effective than metformin in improving fasting indexes of glucose metabolism in severely obese, non-diabetic patients.
Topics: Adipose Tissue; Adolescent; Adult; Aged; B-Lymphocytes; Blood Glucose; Body Composition; Female; Hum | 2008 |
Beneficial effects of metformin in normoglycemic morbidly obese adolescents.
Topics: Adipose Tissue; Adolescent; Blood Glucose; Body Composition; Body Mass Index; Cholesterol; Diet, Red | 2001 |
Beneficial effects of metformin in normoglycemic morbidly obese adolescents.
Topics: Adipose Tissue; Adolescent; Blood Glucose; Body Composition; Body Mass Index; Cholesterol; Diet, Red | 2001 |
Beneficial effects of metformin in normoglycemic morbidly obese adolescents.
Topics: Adipose Tissue; Adolescent; Blood Glucose; Body Composition; Body Mass Index; Cholesterol; Diet, Red | 2001 |
Beneficial effects of metformin in normoglycemic morbidly obese adolescents.
Topics: Adipose Tissue; Adolescent; Blood Glucose; Body Composition; Body Mass Index; Cholesterol; Diet, Red | 2001 |
Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial.
Topics: Adult; Body Mass Index; Double-Blind Method; Female; Fertilization; Humans; Hypoglycemic Agents; Lip | 2002 |
18 other studies available for metformin and Morbid Obesity
| Article | Year |
|---|---|
Physiologically Based Pharmacokinetic Modeling of Metformin in Children and Adolescents With Obesity.
Topics: Adolescent; Adult; Child; Humans; Metformin; Models, Biological; Obesity, Morbid; Overweight; Pediat | 2022 |
[Research progresses on interventions of obesity in children and adolescents].
Topics: Adolescent; Child; Gastrectomy; Gastric Bypass; Humans; Metformin; Obesity, Morbid; Pediatric Obesit | 2023 |
A lower duodenal immune response is associated with an increase of insulin resistance in patients with morbid obesity.
Topics: Adult; Cytokines; Diabetes Mellitus, Type 2; Duodenum; Female; Humans; Hypoglycemic Agents; Insulin | 2020 |
Mucosa-associated microbiota in the jejunum of patients with morbid obesity: alterations in states of insulin resistance and metformin treatment.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Humans; Insulin; Insulin Resistance; Jejunum; Metformin; M | 2020 |
Case Report: Off Label Utilization of Topiramate and Metformin in Patients With BMI ≥50 kg/m
Topics: Adult; Anti-Obesity Agents; Bariatric Surgery; Body Mass Index; Combined Modality Therapy; Drug Ther | 2021 |
Risk of Metformin-Associated Lactic Acidosis (MALA) in Patients After Gastric Bypass Surgery.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Female; Gastric Bypass; Humans; Hypoglycemic Agents; La | 2018 |
A novel mutation in the proopiomelanocortin (POMC) gene of a Hispanic child: metformin treatment shows a beneficial impact on the body mass index.
Topics: Adrenal Insufficiency; Adult; Body Mass Index; Child; Child, Preschool; Female; Hispanic or Latino; | 2018 |
Update in endocrinology: evidence published in 2012.
Topics: Biliopancreatic Diversion; Bone Density; Bone Density Conservation Agents; Bone Diseases, Metabolic; | 2013 |
Effects of metformin in children and adolescents with Prader-Willi syndrome and early-onset morbid obesity: a pilot study.
Topics: Adolescent; Age of Onset; Child; Female; Glucose Tolerance Test; Humans; Hyperphagia; Male; Metformi | 2014 |
[Liraglutide in polycystic ovary syndrome].
Topics: Adult; Diabetes Mellitus, Type 2; Drug Synergism; Female; Glucagon-Like Peptide 1; Hirsutism; Humans | 2014 |
Effective weight loss after treatment with a glucagon-like peptide-1 receptor agonist in a morbidly obese and diabetic patient before bariatric surgery: a case report.
Topics: Adult; Bariatric Surgery; Combined Modality Therapy; Diabetes Mellitus, Type 2; Exenatide; Female; G | 2014 |
Adipose tissue biomarkers involved in early resolution of type 2 diabetes after bariatric surgery.
Topics: Antigens, CD; Bariatric Surgery; Biomarkers; Caspase 3; Diabetes Mellitus, Type 2; Female; Humans; H | 2017 |
Unusual glycogenic hepatopathy causing abnormal liver enzymes in a morbidly obese adolescent with well-controlled type 2 diabetes: resolved after A1c was normalized by metformin.
Topics: Adolescent; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Liver Diseases; Male; Metformin; | 2016 |
Liraglutide therapy in Prader-Willi syndrome.
Topics: Adolescent; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glucagon-Like Peptide 1; H | 2011 |
GLUT2 accumulation in enterocyte apical and intracellular membranes: a study in morbidly obese human subjects and ob/ob and high fat-fed mice.
Topics: Adult; Animals; Cell Membrane; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Dietary Fats; Enter | 2011 |
Acute renal failure after intragastric balloon in morbidly-obese metformin-treated diabetic patients. Report of two cases.
Topics: Adult; Diabetes Mellitus; Female; Gastric Balloon; Humans; Kidney Diseases; Male; Metformin; Middle | 2012 |
Case 25-2004: a woman with severe obesity, diabetes, and hypertension.
Topics: Diabetes Mellitus, Type 1; Female; Gastric Bypass; Humans; Hypoglycemic Agents; Metformin; Obesity, | 2004 |
Case records of the Massachusetts General Hospital. Case 31-2006. A 15-year-old girl with severe obesity.
Topics: Acanthosis Nigricans; Adolescent; Body Mass Index; Diabetes Mellitus, Type 2; Fatty Liver; Female; G | 2006 |