metformin has been researched along with Mitochondrial Diseases in 11 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Mitochondrial Diseases: Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin treatment clearly rescued these cells from rotenone-mediated cell death via the reduction of the cytosolic and mitochondrial levels of reactive oxygen species and restoration of mitochondrial function." | 1.62 | Metformin attenuates rotenone-induced oxidative stress and mitochondrial damage via the AKT/Nrf2 pathway. ( Bhurtel, S; Choi, DY; Katila, N; Park, PH, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 6 (54.55) | 2.80 |
| Authors | Studies |
|---|---|
| Finsterer, J | 1 |
| García-Puga, M | 1 |
| Saenz-Antoñanzas, A | 1 |
| Fernández-Torrón, R | 1 |
| Munain, AL | 1 |
| Matheu, A | 1 |
| Kim, NH | 1 |
| Siddiqui, M | 1 |
| Vogel, J | 1 |
| Espada, L | 1 |
| Dakhovnik, A | 1 |
| Chaudhari, P | 1 |
| Martirosyan, A | 1 |
| Miek, L | 1 |
| Poliezhaieva, T | 1 |
| Schaub, Y | 1 |
| Nair, A | 1 |
| Döring, N | 1 |
| Rahnis, N | 1 |
| Werz, O | 1 |
| Koeberle, A | 1 |
| Kirkpatrick, J | 1 |
| Ori, A | 1 |
| Ermolaeva, MA | 1 |
| Peralta, S | 1 |
| Pinto, M | 1 |
| Arguello, T | 1 |
| Garcia, S | 1 |
| Diaz, F | 1 |
| Moraes, CT | 1 |
| Katila, N | 1 |
| Bhurtel, S | 1 |
| Park, PH | 1 |
| Choi, DY | 1 |
| Yang, S | 1 |
| Han, Y | 1 |
| Liu, J | 1 |
| Song, P | 1 |
| Xu, X | 1 |
| Zhao, L | 1 |
| Hu, C | 1 |
| Xiao, L | 1 |
| Liu, F | 1 |
| Zhang, H | 1 |
| Sun, L | 1 |
| Blake, R | 1 |
| Trounce, IA | 1 |
| Valero, T | 1 |
| Lee, MS | 1 |
| Wang, P | 1 |
| Xu, L | 1 |
| Sun, A | 1 |
4 reviews available for metformin and Mitochondrial Diseases
| Article | Year |
|---|---|
Mitochondria: A Novel Therapeutic Target in Diabetic Nephropathy.
Topics: Animals; Apoptosis; Diabetic Nephropathies; Humans; Hypoglycemic Agents; Metformin; MicroRNAs; Mitoc | 2017 |
Mitochondrial dysfunction and complications associated with diabetes.
Topics: Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans; Hyperglycemia; Insulin; Metformin; Mit | 2014 |
Effect of mitochondrial stress on systemic metabolism.
Topics: Animals; Autophagy; Biomarkers; Energy Metabolism; Fibroblast Growth Factors; Humans; Hypoglycemic A | 2015 |
Energy Remodeling, Mitochondrial Disorder and Heart Failure.
Topics: Aminoimidazole Carboxamide; Animals; Energy Metabolism; Heart Failure; Humans; Hydroxymethylglutaryl | 2016 |
7 other studies available for metformin and Mitochondrial Diseases
| Article | Year |
|---|---|
Metformin in m.3243A>G carriers can be both detrimental and beneficial.
Topics: DNA, Mitochondrial; Heterozygote; Humans; Metformin; Mitochondrial Diseases | 2022 |
Myotonic Dystrophy type 1 cells display impaired metabolism and mitochondrial dysfunction that are reversed by metformin.
Topics: Adult; Aged; Energy Metabolism; Female; Fibroblasts; Humans; Hypoglycemic Agents; Leukocytes, Mononu | 2020 |
MELAS Syndrome and MIDD Unmasked by Metformin Use: A Case Report.
Topics: Adult; Brain; Deafness; Diabetes Mellitus, Type 2; Diagnosis, Differential; Electroencephalography; | 2021 |
Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans.
Topics: Adenosine Triphosphate; Aging; Animals; Caenorhabditis elegans; Caloric Restriction; Glycolysis; Hum | 2020 |
Metformin delays neurological symptom onset in a mouse model of neuronal complex I deficiency.
Topics: Animals; Electron Transport Complex I; Energy Metabolism; Female; Glycolysis; Hypoglycemic Agents; M | 2020 |
Metformin attenuates rotenone-induced oxidative stress and mitochondrial damage via the AKT/Nrf2 pathway.
Topics: Cell Line; Cell Survival; Humans; Hypoglycemic Agents; Metformin; Mitochondrial Diseases; NF-E2-Rela | 2021 |
Mitochondrial biogenesis: pharmacological approaches.
Topics: Animals; DNA, Mitochondrial; Humans; Metformin; Mitochondria; Mitochondrial Diseases; Resveratrol; S | 2014 |