metformin has been researched along with Mesothelioma in 4 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Mesothelioma: A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin suppressed cell growth of 9 kinds of mesothelioma including immortalized cells of mesothelium origin irrespective of the p53 functional status, whereas susceptibility to nutlin-3a was partly dependent on the p53 genotype." | 7.85 | Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways. ( Hiroshima, K; Morinaga, T; Namiki, T; Sekine, I; Shimada, H; Shimazu, K; Shingyoji, M; Tada, Y; Tagawa, M; Tatsumi, K, 2017) |
| "This study aimed to investigate the effect of metformin on survival of people with type 2 diabetes and pleural mesothelioma." | 7.83 | Metformin and survival of people with type 2 diabetes and pleural mesothelioma: A population-based retrospective cohort study. ( Brewster, DH; Damhuis, RA; Walker, J; Wild, SH; Wu, H, 2016) |
| "Metformin suppressed cell growth of 9 kinds of mesothelioma including immortalized cells of mesothelium origin irrespective of the p53 functional status, whereas susceptibility to nutlin-3a was partly dependent on the p53 genotype." | 3.85 | Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways. ( Hiroshima, K; Morinaga, T; Namiki, T; Sekine, I; Shimada, H; Shimazu, K; Shingyoji, M; Tada, Y; Tagawa, M; Tatsumi, K, 2017) |
| "This study aimed to investigate the effect of metformin on survival of people with type 2 diabetes and pleural mesothelioma." | 3.83 | Metformin and survival of people with type 2 diabetes and pleural mesothelioma: A population-based retrospective cohort study. ( Brewster, DH; Damhuis, RA; Walker, J; Wild, SH; Wu, H, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shimazu, K | 1 |
| Tada, Y | 1 |
| Morinaga, T | 1 |
| Shingyoji, M | 1 |
| Sekine, I | 1 |
| Shimada, H | 1 |
| Hiroshima, K | 1 |
| Namiki, T | 1 |
| Tatsumi, K | 1 |
| Tagawa, M | 1 |
| Hwang, SH | 1 |
| Kim, MC | 1 |
| Ji, S | 1 |
| Yang, Y | 1 |
| Jeong, Y | 1 |
| Kim, Y | 1 |
| Lennon, FE | 1 |
| Cianci, GC | 1 |
| Kanteti, R | 1 |
| Riehm, JJ | 1 |
| Arif, Q | 1 |
| Poroyko, VA | 1 |
| Lupovitch, E | 1 |
| Vigneswaran, W | 1 |
| Husain, A | 1 |
| Chen, P | 1 |
| Liao, JK | 1 |
| Sattler, M | 1 |
| Kindler, HL | 1 |
| Salgia, R | 1 |
| Wu, H | 1 |
| Walker, J | 1 |
| Damhuis, RA | 1 |
| Brewster, DH | 1 |
| Wild, SH | 1 |
4 other studies available for metformin and Mesothelioma
| Article | Year |
|---|---|
Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Imidazoles; Lung Ne | 2017 |
Glucose starvation induces resistance to metformin through the elevation of mitochondrial multidrug resistance protein 1.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Autophagy; Cell Line; Cell Proli | 2019 |
Unique fractal evaluation and therapeutic implications of mitochondrial morphology in malignant mesothelioma.
Topics: Cell Line, Tumor; Cisplatin; Fractals; Glycolysis; Humans; Lung Neoplasms; Mesothelioma; Mesotheliom | 2016 |
Metformin and survival of people with type 2 diabetes and pleural mesothelioma: A population-based retrospective cohort study.
Topics: Aged; Aged, 80 and over; Cause of Death; Cohort Studies; Diabetes Mellitus, Type 2; Female; Humans; | 2016 |