metformin has been researched along with Maternal Obesity in 6 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "For pregnant women who are overweight or obese, metformin given in addition to dietary and lifestyle advice initiated at 10-20 weeks' gestation does not improve pregnancy and birth outcomes." | 9.30 | Effect of metformin in addition to dietary and lifestyle advice for pregnant women who are overweight or obese: the GRoW randomised, double-blind, placebo-controlled trial. ( Dekker, G; Deussen, AR; Dodd, JM; Grivell, RM; Hague, W; Louise, J; McPhee, AJ, 2019) |
| "Gestational metformin attenuated the adiposity in obese dams and increased the gestation length without correcting the offspring in utero growth restriction and catch-up growth caused by maternal obesity." | 8.02 | Maternal Metformin Intervention during Obese Glucose-Intolerant Pregnancy Affects Adiposity in Young Adult Mouse Offspring in a Sex-Specific Manner. ( Aiken, CE; Ashmore, TJ; Blackmore, HL; Fernandez-Twinn, DS; Ozanne, SE; Schoonejans, JM, 2021) |
| "Metformin is an effective glucose lowering drug commonly used to treat gestational diabetes mellitus; however, its wider effects on maternal and fetal health are poorly explored." | 5.72 | Maternal but not fetoplacental health can be improved by metformin in a murine diet-induced model of maternal obesity and glucose intolerance. ( Aiken, CE; Ashmore, TJ; Blackmore, HL; Fernandez-Twinn, DS; Hargreaves, IP; Heaton, RA; Hufnagel, A; Jenkins, B; Koulman, A; Ozanne, SE, 2022) |
| "For pregnant women who are overweight or obese, metformin given in addition to dietary and lifestyle advice initiated at 10-20 weeks' gestation does not improve pregnancy and birth outcomes." | 5.30 | Effect of metformin in addition to dietary and lifestyle advice for pregnant women who are overweight or obese: the GRoW randomised, double-blind, placebo-controlled trial. ( Dekker, G; Deussen, AR; Dodd, JM; Grivell, RM; Hague, W; Louise, J; McPhee, AJ, 2019) |
| "Gestational metformin attenuated the adiposity in obese dams and increased the gestation length without correcting the offspring in utero growth restriction and catch-up growth caused by maternal obesity." | 4.02 | Maternal Metformin Intervention during Obese Glucose-Intolerant Pregnancy Affects Adiposity in Young Adult Mouse Offspring in a Sex-Specific Manner. ( Aiken, CE; Ashmore, TJ; Blackmore, HL; Fernandez-Twinn, DS; Ozanne, SE; Schoonejans, JM, 2021) |
| "Metformin is an effective glucose lowering drug commonly used to treat gestational diabetes mellitus; however, its wider effects on maternal and fetal health are poorly explored." | 1.72 | Maternal but not fetoplacental health can be improved by metformin in a murine diet-induced model of maternal obesity and glucose intolerance. ( Aiken, CE; Ashmore, TJ; Blackmore, HL; Fernandez-Twinn, DS; Hargreaves, IP; Heaton, RA; Hufnagel, A; Jenkins, B; Koulman, A; Ozanne, SE, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 3 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hufnagel, A | 1 |
| Fernandez-Twinn, DS | 2 |
| Blackmore, HL | 2 |
| Ashmore, TJ | 2 |
| Heaton, RA | 1 |
| Jenkins, B | 1 |
| Koulman, A | 1 |
| Hargreaves, IP | 1 |
| Aiken, CE | 2 |
| Ozanne, SE | 2 |
| Souza, MLR | 1 |
| Silva, RRE | 1 |
| Silva, TRE | 1 |
| Oliveira, LC | 1 |
| Dienstmann, G | 1 |
| Nascimento, IBD | 1 |
| Silva, JC | 1 |
| Panagiotopoulou, O | 1 |
| Syngelaki, A | 1 |
| Georgiopoulos, G | 1 |
| Simpson, J | 1 |
| Akolekar, R | 1 |
| Shehata, H | 1 |
| Nicolaides, K | 1 |
| Charakida, M | 1 |
| Schoonejans, JM | 1 |
| Vora, NL | 1 |
| Grace, MR | 1 |
| Smeester, L | 1 |
| Dotters-Katz, SK | 1 |
| Fry, RC | 1 |
| Bae-Jump, V | 1 |
| Boggess, K | 1 |
| Dodd, JM | 1 |
| Louise, J | 1 |
| Deussen, AR | 1 |
| Grivell, RM | 1 |
| Dekker, G | 1 |
| McPhee, AJ | 1 |
| Hague, W | 1 |
2 trials available for metformin and Maternal Obesity
| Article | Year |
|---|---|
Metformin use in obese mothers is associated with improved cardiovascular profile in the offspring.
Topics: Adiponectin; Adult; Arterial Pressure; Blood Pressure; Body Composition; Child, Preschool; Cholester | 2020 |
Effect of metformin in addition to dietary and lifestyle advice for pregnant women who are overweight or obese: the GRoW randomised, double-blind, placebo-controlled trial.
Topics: Adult; Diet Therapy; Double-Blind Method; Exercise; Female; Fetal Macrosomia; Gestational Weight Gai | 2019 |
4 other studies available for metformin and Maternal Obesity
| Article | Year |
|---|---|
Maternal but not fetoplacental health can be improved by metformin in a murine diet-induced model of maternal obesity and glucose intolerance.
Topics: Animals; Diet, High-Fat; Female; Fetal Growth Retardation; Glucose Intolerance; Humans; Infectious D | 2022 |
Factors Associated with the Need for Insulin as a Complementary Treatment to Metformin in Gestational Diabetes Mellitus.
Topics: Adult; Blood Glucose; Case-Control Studies; Diabetes, Gestational; Drug Therapy, Combination; Exerci | 2019 |
Maternal Metformin Intervention during Obese Glucose-Intolerant Pregnancy Affects Adiposity in Young Adult Mouse Offspring in a Sex-Specific Manner.
Topics: Adiposity; Animals; Animals, Newborn; Diabetes, Gestational; Female; Male; Metformin; Mice; Mice, In | 2021 |
Targeted Multiplex Gene Expression Profiling to Measure High-Fat Diet and Metformin Effects on Fetal Gene Expression in a Mouse Model.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Female; Fetal Development; Gene Expression; Gene Ex | 2019 |