metformin has been researched along with Maple Syrup Urine Disease in 2 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Maple Syrup Urine Disease: An autosomal recessive inherited disorder with multiple forms of phenotypic expression, caused by a defect in the oxidative decarboxylation of branched-chain amino acids (AMINO ACIDS, BRANCHED-CHAIN). These metabolites accumulate in body fluids and render a maple syrup odor. The disease is divided into classic, intermediate, intermittent, and thiamine responsive subtypes. The classic form presents in the first week of life with ketoacidosis, hypoglycemia, emesis, neonatal seizures, and hypertonia. The intermediate and intermittent forms present in childhood or later with acute episodes of ataxia and vomiting. (From Adams et al., Principles of Neurology, 6th ed, p936)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tsai, HY | 1 |
| Wu, SC | 1 |
| Li, JC | 1 |
| Chen, YM | 1 |
| Chan, CC | 1 |
| Chen, CH | 1 |
| S Sonnet, D | 1 |
| N O'Leary, M | 1 |
| A Gutierrez, M | 1 |
| M Nguyen, S | 1 |
| Mateen, S | 1 |
| Hsu, Y | 1 |
| P Mitchell, K | 1 |
| J Lopez, A | 1 |
| Vockley, J | 1 |
| K Kennedy, B | 1 |
| Ramanathan, A | 1 |
2 other studies available for metformin and Maple Syrup Urine Disease
| Article | Year |
|---|---|
Loss of the
Topics: Amino Acids, Branched-Chain; Animals; Animals, Genetically Modified; Apoptosis; Brain; Casein Kinase | 2020 |
Metformin inhibits Branched Chain Amino Acid (BCAA) derived ketoacidosis and promotes metabolic homeostasis in MSUD.
Topics: Amino Acids, Branched-Chain; Animals; Chromatography, Liquid; Disease Models, Animal; Female; Fibrob | 2016 |