metformin has been researched along with Malaria in 5 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin has well known anti-malarial properties." | 2.55 | Malaria and diabetes. ( Aggarwal, S; Dutta, D; Kalra, S; Khandelwal, D; Singla, R, 2017) |
| "KRas is frequently mutated in pancreatic cancers." | 1.62 | GSK-3β Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals. ( Abrams, SL; Akula, SM; Candido, S; Cervello, M; Cocco, L; Duda, P; Falzone, L; Gizak, A; Libra, M; Martelli, AM; McCubrey, JA; Meher, AK; Montalto, G; Rakus, D; Ratti, S; Ruvolo, P; Steelman, LS, 2021) |
| "Pretreatment with metformin for 21 days followed by infection with P." | 1.51 | Plasmodium Infection Induces Dyslipidemia and a Hepatic Lipogenic State in the Host through the Inhibition of the AMPK-ACC Pathway. ( Araujo, MFC; Atella, GC; Atella, TC; da Rocha, I; Imperio, GED; Kluck, GEG; Miranda, KR; Wendt, CHC, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kluck, GEG | 1 |
| Wendt, CHC | 1 |
| Imperio, GED | 1 |
| Araujo, MFC | 1 |
| Atella, TC | 1 |
| da Rocha, I | 1 |
| Miranda, KR | 1 |
| Atella, GC | 1 |
| Vera, IM | 1 |
| Grilo Ruivo, MT | 1 |
| Lemos Rocha, LF | 1 |
| Marques, S | 1 |
| Bhatia, SN | 1 |
| Mota, MM | 1 |
| Mancio-Silva, L | 1 |
| Abrams, SL | 1 |
| Akula, SM | 1 |
| Meher, AK | 1 |
| Steelman, LS | 1 |
| Gizak, A | 1 |
| Duda, P | 1 |
| Rakus, D | 1 |
| Martelli, AM | 1 |
| Ratti, S | 1 |
| Cocco, L | 1 |
| Montalto, G | 1 |
| Cervello, M | 1 |
| Ruvolo, P | 1 |
| Libra, M | 1 |
| Falzone, L | 1 |
| Candido, S | 1 |
| McCubrey, JA | 1 |
| Kalra, S | 1 |
| Khandelwal, D | 1 |
| Singla, R | 1 |
| Aggarwal, S | 1 |
| Dutta, D | 1 |
| Miyakoda, M | 1 |
| Bayarsaikhan, G | 1 |
| Kimura, D | 1 |
| Akbari, M | 1 |
| Udono, H | 1 |
| Yui, K | 1 |
1 review available for metformin and Malaria
| Article | Year |
|---|---|
Malaria and diabetes.
Topics: Animals; Antimalarials; Diabetes Mellitus, Type 2; Female; Glucosephosphate Dehydrogenase Deficiency | 2017 |
4 other studies available for metformin and Malaria
| Article | Year |
|---|---|
Plasmodium Infection Induces Dyslipidemia and a Hepatic Lipogenic State in the Host through the Inhibition of the AMPK-ACC Pathway.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Cholesterol; Dyslipidemias; Fatty Ac | 2019 |
Targeting liver stage malaria with metformin.
Topics: Animals; Antimalarials; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Drug | 2019 |
GSK-3β Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals.
Topics: Adenocarcinoma; Adenylate Kinase; Antineoplastic Agents; bcl-X Protein; Berberine; Biphenyl Compound | 2021 |
Metformin Promotes the Protection of Mice Infected With
Topics: Animals; Disease Models, Animal; Female; Humans; Lymphocyte Activation; Malaria; Metformin; Mice; Mi | 2018 |