metformin has been researched along with Macular Degeneration in 22 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Macular Degeneration: Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin is a biguanide derivative that is commonly used for the treatment of diabetes mellitus (DM)." | 9.22 | Association Between Oral Metformin Use and the Development of Age-Related Macular Degeneration in Diabetic Patients: A Systematic Review and Meta-Analysis. ( Chang, CY; Chen, CH; Chen, TL; Hsu, WC; Liang, KH; Tsai, HR, 2022) |
| "To investigate the association between metformin use and age-related macular degeneration (AMD)." | 8.31 | Association of Metformin With the Development of Age-Related Macular Degeneration. ( Chew, EY; Dabelea, DM; Darwin, CH; Domalpally, A; Knowler, WC; Lee, CG; Luchsinger, JA; Pan, Q; White, NH; Whittier, SA, 2023) |
| "To investigate if metformin use is associated with decreased odds of developing new non-neovascular ("dry") age-related macular degeneration (AMD)." | 8.31 | Association of Metformin and Other Diabetes Medication Use and the Development of New-Onset Dry Age-Related Macular Degeneration: A Case-Control Study. ( Gonnah, R; Hariprasad, S; Hyman, MJ; Kaufmann, GT; Skondra, D, 2023) |
| "To investigate the effect of metformin on the decreased risk of developing age-related macular degeneration (AMD) in patients with type 2 diabetes mellitus (T2DM) for ≥10 years." | 8.12 | Association between metformin use and the risk of age-related macular degeneration in patients with type 2 diabetes: a retrospective study. ( Chen, Y; Fan, G; Jiang, J; Wang, N; Wang, Z; Yuan, W; Zhang, H; Zhao, T; Zheng, D, 2022) |
| "To assess whether metformin is associated with dry age-related macular degeneration (dAMD) development." | 8.12 | Association of metformin and development of dry age-related macular degeneration in a U.S. insurance claims database. ( Besirli, CG; Eton, EA; Hua, P; McGeehan, B; VanderBeek, BL; Wubben, TJ, 2022) |
| "Statins, metformin, angiotensin-converting enzyme (ACE) inhibitors, and angiotensin receptor blockers (ARBs) have been suggested for treating age-related macular degeneration (AMD) due to their pleiotropic effects." | 7.91 | Effect of Statins, Metformin, Angiotensin-Converting Enzyme Inhibitors, and Angiotensin II Receptor Blockers on Age-Related Macular Degeneration. ( Jeon, HL; Lee, H; Park, SJ; Shin, JY, 2019) |
| "Patients aged ≥40 with diagnosed type 2 diabetes were included." | 5.91 | Metformin and risk of age-related macular degeneration in individuals with type 2 diabetes: a retrospective cohort study. ( Adderley, NJ; Braithwaite, T; Coker, J; Denniston, AK; Gokhale, KM; Han, D; Keane, PA; Lee, WH; Nirantharakumar, K; Subramanian, A, 2023) |
| "Metformin use was associated with reduced odds of developing AMD (odds ratio [OR], 0." | 5.62 | Association of Metformin Use With Age-Related Macular Degeneration: A Case-Control Study. ( Blitzer, AL; Colby, KA; Ham, SA; Skondra, D, 2021) |
| "Metformin use was associated with decreased odds of developing AMD, independently of the other covariates investigated, with an odds ratio of 0." | 5.51 | The Common Antidiabetic Drug Metformin Reduces Odds of Developing Age-Related Macular Degeneration. ( Ash, JD; Ball, JD; Brown, EE; Chen, Z; Khurshid, GS; Prosperi, M, 2019) |
| "Metformin is a biguanide derivative that is commonly used for the treatment of diabetes mellitus (DM)." | 5.22 | Association Between Oral Metformin Use and the Development of Age-Related Macular Degeneration in Diabetic Patients: A Systematic Review and Meta-Analysis. ( Chang, CY; Chen, CH; Chen, TL; Hsu, WC; Liang, KH; Tsai, HR, 2022) |
| "To investigate the association between metformin use and age-related macular degeneration (AMD)." | 4.31 | Association of Metformin With the Development of Age-Related Macular Degeneration. ( Chew, EY; Dabelea, DM; Darwin, CH; Domalpally, A; Knowler, WC; Lee, CG; Luchsinger, JA; Pan, Q; White, NH; Whittier, SA, 2023) |
| "To investigate if metformin use is associated with decreased odds of developing new non-neovascular ("dry") age-related macular degeneration (AMD)." | 4.31 | Association of Metformin and Other Diabetes Medication Use and the Development of New-Onset Dry Age-Related Macular Degeneration: A Case-Control Study. ( Gonnah, R; Hariprasad, S; Hyman, MJ; Kaufmann, GT; Skondra, D, 2023) |
| "To investigate the effect of metformin on the decreased risk of developing age-related macular degeneration (AMD) in patients with type 2 diabetes mellitus (T2DM) for ≥10 years." | 4.12 | Association between metformin use and the risk of age-related macular degeneration in patients with type 2 diabetes: a retrospective study. ( Chen, Y; Fan, G; Jiang, J; Wang, N; Wang, Z; Yuan, W; Zhang, H; Zhao, T; Zheng, D, 2022) |
| "Recent studies suggest that the diabetes drug metformin has a protective effect on open-angle glaucoma (OAG) and age-related macular degeneration (AMD)." | 4.12 | Association of Diabetes Medication With Open-Angle Glaucoma, Age-Related Macular Degeneration, and Cataract in the Rotterdam Study. ( Ahmadizar, F; Kavousi, M; Klaver, CCW; Ramdas, WD; Stricker, BH; Thee, EF; van Duijn, CM; Vergroesen, JE, 2022) |
| "To assess whether metformin is associated with dry age-related macular degeneration (dAMD) development." | 4.12 | Association of metformin and development of dry age-related macular degeneration in a U.S. insurance claims database. ( Besirli, CG; Eton, EA; Hua, P; McGeehan, B; VanderBeek, BL; Wubben, TJ, 2022) |
| "Patients aged ≥40 with diagnosed type 2 diabetes were included." | 1.91 | Metformin and risk of age-related macular degeneration in individuals with type 2 diabetes: a retrospective cohort study. ( Adderley, NJ; Braithwaite, T; Coker, J; Denniston, AK; Gokhale, KM; Han, D; Keane, PA; Lee, WH; Nirantharakumar, K; Subramanian, A, 2023) |
| "Metformin use was associated with reduced odds of developing AMD (odds ratio [OR], 0." | 1.62 | Association of Metformin Use With Age-Related Macular Degeneration: A Case-Control Study. ( Blitzer, AL; Colby, KA; Ham, SA; Skondra, D, 2021) |
| "Metformin use was associated with decreased odds of developing AMD, independently of the other covariates investigated, with an odds ratio of 0." | 1.51 | The Common Antidiabetic Drug Metformin Reduces Odds of Developing Age-Related Macular Degeneration. ( Ash, JD; Ball, JD; Brown, EE; Chen, Z; Khurshid, GS; Prosperi, M, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (18.18) | 24.3611 |
| 2020's | 18 (81.82) | 2.80 |
| Authors | Studies |
|---|---|
| Amin, SV | 1 |
| Khanna, S | 1 |
| Parvar, SP | 1 |
| Shaw, LT | 1 |
| Dao, D | 1 |
| Hariprasad, SM | 1 |
| Skondra, D | 4 |
| Gokhale, KM | 1 |
| Adderley, NJ | 1 |
| Subramanian, A | 1 |
| Lee, WH | 1 |
| Han, D | 1 |
| Coker, J | 1 |
| Braithwaite, T | 1 |
| Denniston, AK | 1 |
| Keane, PA | 1 |
| Nirantharakumar, K | 1 |
| Jiang, J | 1 |
| Chen, Y | 1 |
| Zhang, H | 1 |
| Yuan, W | 1 |
| Zhao, T | 1 |
| Wang, N | 1 |
| Fan, G | 1 |
| Zheng, D | 1 |
| Wang, Z | 1 |
| Vergroesen, JE | 1 |
| Thee, EF | 1 |
| Ahmadizar, F | 1 |
| van Duijn, CM | 1 |
| Stricker, BH | 1 |
| Kavousi, M | 1 |
| Klaver, CCW | 1 |
| Ramdas, WD | 1 |
| Liang, KH | 2 |
| Chen, CH | 2 |
| Tsai, HR | 2 |
| Chang, CY | 2 |
| Chen, TL | 2 |
| Hsu, WC | 2 |
| Domalpally, A | 2 |
| Whittier, SA | 1 |
| Pan, Q | 2 |
| Dabelea, DM | 1 |
| Darwin, CH | 1 |
| Knowler, WC | 1 |
| Lee, CG | 1 |
| Luchsinger, JA | 1 |
| White, NH | 1 |
| Chew, EY | 2 |
| Holtz, JK | 1 |
| Thinggaard, BS | 1 |
| Grauslund, J | 1 |
| Subhi, Y | 1 |
| Asensio-Sánchez, VM | 1 |
| Francisco, SG | 1 |
| Rowan, S | 2 |
| Kaufmann, GT | 1 |
| Hyman, MJ | 1 |
| Gonnah, R | 1 |
| Hariprasad, S | 1 |
| Stewart, JM | 1 |
| Lamy, R | 1 |
| Wu, F | 1 |
| Keenan, JD | 1 |
| Qu, S | 1 |
| Zhang, C | 1 |
| Liu, D | 1 |
| Wu, J | 1 |
| Tian, H | 1 |
| Lu, L | 1 |
| Xu, GT | 1 |
| Liu, F | 1 |
| Zhang, J | 1 |
| McGuinness, MB | 1 |
| Kasza, J | 1 |
| Guymer, RH | 1 |
| Blitzer, AL | 2 |
| Ham, SA | 2 |
| Colby, KA | 1 |
| Eton, EA | 1 |
| Wubben, TJ | 1 |
| Besirli, CG | 1 |
| Hua, P | 1 |
| McGeehan, B | 1 |
| VanderBeek, BL | 1 |
| Etminan, M | 1 |
| Sodhi, M | 1 |
| Li, L | 1 |
| Brown, EE | 2 |
| Lewin, AS | 1 |
| Ash, JD | 2 |
| Taylor, A | 1 |
| Ball, JD | 1 |
| Chen, Z | 1 |
| Khurshid, GS | 1 |
| Prosperi, M | 1 |
| Lee, H | 1 |
| Jeon, HL | 1 |
| Park, SJ | 1 |
| Shin, JY | 1 |
5 reviews available for metformin and Macular Degeneration
| Article | Year |
|---|---|
Metformin and retinal diseases in preclinical and clinical studies: Insights and review of literature.
Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Glaucoma, Open-Angle; Macular Degeneration | 2022 |
Association Between Oral Metformin Use and the Development of Age-Related Macular Degeneration in Diabetic Patients: A Systematic Review and Meta-Analysis.
Topics: Diabetes Mellitus; Ethnicity; Humans; Macular Degeneration; Metformin; Odds Ratio | 2022 |
Association Between Oral Metformin Use and the Development of Age-Related Macular Degeneration in Diabetic Patients: A Systematic Review and Meta-Analysis.
Topics: Diabetes Mellitus; Ethnicity; Humans; Macular Degeneration; Metformin; Odds Ratio | 2022 |
Association Between Oral Metformin Use and the Development of Age-Related Macular Degeneration in Diabetic Patients: A Systematic Review and Meta-Analysis.
Topics: Diabetes Mellitus; Ethnicity; Humans; Macular Degeneration; Metformin; Odds Ratio | 2022 |
Association Between Oral Metformin Use and the Development of Age-Related Macular Degeneration in Diabetic Patients: A Systematic Review and Meta-Analysis.
Topics: Diabetes Mellitus; Ethnicity; Humans; Macular Degeneration; Metformin; Odds Ratio | 2022 |
Association between oral metformin use and the risk of age-related macular degeneration: A systematic review with meta-analysis.
Topics: Diabetes Mellitus, Type 2; Humans; Macular Degeneration; Metformin | 2023 |
Mitochondria: Potential Targets for Protection in Age-Related Macular Degeneration.
Topics: Adenylate Kinase; Animals; Disease Models, Animal; DNA, Mitochondrial; Drug Evaluation, Preclinical; | 2018 |
The Role of Microbiota in Retinal Disease.
Topics: Animals; Conjunctiva; Cornea; Diabetic Retinopathy; Disease Models, Animal; Gastrointestinal Microbi | 2018 |
17 other studies available for metformin and Macular Degeneration
| Article | Year |
|---|---|
Metformin and risk of age-related macular degeneration in individuals with type 2 diabetes: a retrospective cohort study.
Topics: Cohort Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Macular Degeneration | 2023 |
Association between metformin use and the risk of age-related macular degeneration in patients with type 2 diabetes: a retrospective study.
Topics: Diabetes Mellitus, Type 2; Diabetic Retinopathy; Humans; Hypoglycemic Agents; Macular Degeneration; | 2022 |
Association of Diabetes Medication With Open-Angle Glaucoma, Age-Related Macular Degeneration, and Cataract in the Rotterdam Study.
Topics: Aged; Cataract; Cohort Studies; Diabetes Mellitus, Type 2; Female; Glaucoma, Open-Angle; Humans; Ins | 2022 |
Association of Metformin With the Development of Age-Related Macular Degeneration.
Topics: Child; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Macular Degeneration; Mal | 2023 |
Association of Metformin With the Development of Age-Related Macular Degeneration in the Diabetes Prevention Program Outcomes Study.
Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Macular Degeneration; Metformin | 2023 |
Association of Metformin With the Development of Age-related Macular Degeneration in the Diabetes Prevention Program Outcomes Study-Reply.
Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Macular Degeneration; Metformin | 2023 |
Repurposing Drugs for Treatment of Age-Related Macular Degeneration.
Topics: Drug Repositioning; Humans; Levodopa; Macular Degeneration; Metformin | 2023 |
Association of Metformin and Other Diabetes Medication Use and the Development of New-Onset Dry Age-Related Macular Degeneration: A Case-Control Study.
Topics: Case-Control Studies; Diabetes Mellitus; Diabetic Retinopathy; Geographic Atrophy; Humans; Macular D | 2023 |
Relationship between Oral Metformin Use and Age-Related Macular Degeneration.
Topics: Administration, Oral; Cross-Sectional Studies; Diabetes Mellitus; Female; Follow-Up Studies; Humans; | 2020 |
Metformin Protects ARPE-19 Cells from Glyoxal-Induced Oxidative Stress.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Cell Line; Disease Models, Animal; Glyoxal; Humans; H | 2020 |
Is There a Case for Case-Control Studies in the Exploration of Retrospective Data Sets?
Topics: Case-Control Studies; Humans; Macular Degeneration; Metformin; Retrospective Studies | 2021 |
Association of Metformin Use With Age-Related Macular Degeneration: A Case-Control Study.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Diabetes Mellitus; Female; Humans; Hypoglycemic Agent | 2021 |
Association of metformin and development of dry age-related macular degeneration in a U.S. insurance claims database.
Topics: Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Incidence; Insurance; Macular Degene | 2022 |
Methodological Considerations for the Case-Control Study of Metformin and Age-Related Macular Degeneration.
Topics: Case-Control Studies; Humans; Hypoglycemic Agents; Macular Degeneration; Metformin | 2021 |
Methodological Considerations for the Case-Control Study of Metformin and Age-Related Macular Degeneration-Reply.
Topics: Case-Control Studies; Humans; Hypoglycemic Agents; Macular Degeneration; Metformin | 2021 |
The Common Antidiabetic Drug Metformin Reduces Odds of Developing Age-Related Macular Degeneration.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Databases, Factual; Diabetes Mellitus, Type 2; Female | 2019 |
Effect of Statins, Metformin, Angiotensin-Converting Enzyme Inhibitors, and Angiotensin II Receptor Blockers on Age-Related Macular Degeneration.
Topics: Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Case-Control Studi | 2019 |