metformin has been researched along with MELAS Syndrome in 4 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
MELAS Syndrome: A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 40-year-old man with sensorineural hearing loss and diabetes mellitus was hospitalized with acute-onset impaired consciousness and clumsiness in his left hand." | 5.91 | Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes diagnosed after metformin-triggered stroke-like episodes. ( Ishiguchi, H; Ito, H; Murakami, K; Sakamoto, K, 2023) |
| "A 40-year-old man with sensorineural hearing loss and diabetes mellitus was hospitalized with acute-onset impaired consciousness and clumsiness in his left hand." | 1.91 | Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes diagnosed after metformin-triggered stroke-like episodes. ( Ishiguchi, H; Ito, H; Murakami, K; Sakamoto, K, 2023) |
| "m." | 1.72 | Neurological manifestations in m.3243A>G-related disease triggered by metformin. ( Chan, KW; Ching, CK; Lam, SF; Lee, HH; Li, JK; Sheng, B; Tam, HV; Tong, HF; Tong, TT, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 4 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tong, HF | 1 |
| Lee, HH | 1 |
| Tong, TT | 1 |
| Lam, SF | 1 |
| Sheng, B | 1 |
| Chan, KW | 1 |
| Li, JK | 1 |
| Tam, HV | 1 |
| Ching, CK | 1 |
| Murakami, K | 1 |
| Sakamoto, K | 1 |
| Ishiguchi, H | 1 |
| Ito, H | 1 |
| Kim, NH | 1 |
| Siddiqui, M | 1 |
| Vogel, J | 1 |
| Trebach, J | 1 |
| Ghazali, D | 1 |
| Burke, DJ | 1 |
| Mahonski, SG | 1 |
| Hoffman, RS | 1 |
4 other studies available for metformin and MELAS Syndrome
| Article | Year |
|---|---|
Neurological manifestations in m.3243A>G-related disease triggered by metformin.
Topics: Deafness; Diabetes Mellitus; DNA, Mitochondrial; Hearing Loss; Humans; MELAS Syndrome; Metformin | 2022 |
Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes diagnosed after metformin-triggered stroke-like episodes.
Topics: Acidosis, Lactic; Adult; Hearing Loss, Sensorineural; Humans; Male; MELAS Syndrome; Metformin; Strok | 2023 |
MELAS Syndrome and MIDD Unmasked by Metformin Use: A Case Report.
Topics: Adult; Brain; Deafness; Diabetes Mellitus, Type 2; Diagnosis, Differential; Electroencephalography; | 2021 |
Initiation of metformin in MELAS patient-a dangerous combination.
Topics: Cognition; Diabetes Mellitus, Type 2; Humans; MELAS Syndrome; Metformin | 2022 |