metformin has been researched along with Lymphoma, Large B-Cell, Diffuse in 4 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Lymphoma, Large B-Cell, Diffuse: Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study investigated the effects of statins in patients with diffuse large B-cell lymphoma (DLBCL) receiving rituximab-based chemoimmunotherapy, and the impact of commonly used drugs, metformin and aspirin, on the clinical outcomes of patients receiving chemoimmunotherapy." | 7.77 | Effect of concomitant statin, metformin, or aspirin on rituximab treatment for diffuse large B-cell lymphoma. ( Ha, T; Koo, YX; Lim, ST; Ong, WS; Quek, R; Tai, DW; Tan, DS; Tan, IB; Tao, M, 2011) |
| " This study investigated the effects of statins in patients with diffuse large B-cell lymphoma (DLBCL) receiving rituximab-based chemoimmunotherapy, and the impact of commonly used drugs, metformin and aspirin, on the clinical outcomes of patients receiving chemoimmunotherapy." | 3.77 | Effect of concomitant statin, metformin, or aspirin on rituximab treatment for diffuse large B-cell lymphoma. ( Ha, T; Koo, YX; Lim, ST; Ong, WS; Quek, R; Tai, DW; Tan, DS; Tan, IB; Tao, M, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Y | 1 |
| Kimpara, S | 1 |
| Hoang, NM | 1 |
| Daenthanasanmak, A | 1 |
| Li, Y | 1 |
| Lu, L | 1 |
| Ngo, VN | 1 |
| Bates, PD | 1 |
| Song, L | 1 |
| Gao, X | 1 |
| Bebel, S | 1 |
| Chen, M | 1 |
| Chen, R | 1 |
| Zhang, X | 1 |
| Selberg, PE | 1 |
| Kenkre, VP | 1 |
| Waldmann, TA | 1 |
| Capitini, CM | 1 |
| Rui, L | 1 |
| Wang, Y | 1 |
| Maurer, MJ | 1 |
| Larson, MC | 1 |
| Allmer, C | 1 |
| Feldman, AL | 1 |
| Bennani, NN | 1 |
| Thompson, CA | 1 |
| Porrata, LF | 1 |
| Habermann, TM | 1 |
| Witzig, TE | 1 |
| Ansell, SM | 1 |
| Slager, SL | 1 |
| Nowakowski, GS | 1 |
| Cerhan, JR | 1 |
| Alkhatib, Y | 1 |
| Abdel Rahman, Z | 1 |
| Kuriakose, P | 1 |
| Koo, YX | 1 |
| Tan, DS | 1 |
| Tan, IB | 1 |
| Tai, DW | 1 |
| Ha, T | 1 |
| Ong, WS | 1 |
| Quek, R | 1 |
| Tao, M | 1 |
| Lim, ST | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Metformin in Combination With R-CHOP for the First Line Treatment of Patients With Diffuse Large B-cell Lymphoma[NCT03200015] | Phase 2 | 15 participants (Actual) | Interventional | 2017-10-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for metformin and Lymphoma, Large B-Cell, Diffuse
| Article | Year |
|---|---|
Impact of metformin use on the outcomes of newly diagnosed diffuse large B-cell lymphoma and follicular lymphoma.
Topics: Aged; Disease-Free Survival; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Metformin; Middl | 2019 |
3 other studies available for metformin and Lymphoma, Large B-Cell, Diffuse
| Article | Year |
|---|---|
EGR1-mediated metabolic reprogramming to oxidative phosphorylation contributes to ibrutinib resistance in B-cell lymphoma.
Topics: Adult; Agammaglobulinaemia Tyrosine Kinase; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug R | 2023 |
Clinical impact of metformin in diabetic diffuse large B-cell lymphoma patients: a case-control study.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Case-Control Stu | 2017 |
Effect of concomitant statin, metformin, or aspirin on rituximab treatment for diffuse large B-cell lymphoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antineoplastic C | 2011 |