Page last updated: 2024-10-30

metformin and Lupus Nephritis

metformin has been researched along with Lupus Nephritis in 4 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Lupus Nephritis: Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

Research Excerpts

ExcerptRelevanceReference
" This research used in vivo and in vitro experiments to explore the therapeutic potential of metformin in kidney injury from LN-induced inflammation."4.12Metformin improves renal injury of MRL/lpr lupus-prone mice via the AMPK/STAT3 pathway. ( An, N; Chen, XC; Huang, LF; Huang, XR; Li, HY; Liu, HF; Liu, ZJ; Lu, X; Pan, QJ; Su, HY; Wu, D; Wu, HL; Yang, C; Zhu, SP, 2022)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (50.00)24.3611
2020's2 (50.00)2.80

Authors

AuthorsStudies
Chen, XC1
Wu, D1
Wu, HL1
Li, HY1
Yang, C1
Su, HY1
Liu, ZJ1
Huang, XR1
Lu, X1
Huang, LF1
Zhu, SP1
Pan, QJ1
An, N1
Liu, HF1
Cornaby, C1
Elshikha, AS1
Teng, X1
Choi, SC1
Scindia, Y1
Davidson, A1
Morel, L1
Peng, X1
Yang, T1
Liu, G1
Liu, H1
Peng, Y1
He, L1
Wang, H1
Li, T1
Chen, S1
Gu, Y1
Ye, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multicenter, Randomised, Double-blind Placebo Controlled Trial on the Efficacy and Safety of add-on Metformin to Conventional Immunosuppressants in Systemic Lupus Erythematosus[NCT02741960]Phase 4180 participants (Actual)Interventional2016-05-24Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for metformin and Lupus Nephritis

ArticleYear
Neutrophil Extracellular Trap Mitochondrial DNA and Its Autoantibody in Systemic Lupus Erythematosus and a Proof-of-Concept Trial of Metformin.
    Arthritis & rheumatology (Hoboken, N.J.), 2015, Volume: 67, Issue:12

    Topics: Adolescent; Adult; Antibodies, Antinuclear; Arthritis, Rheumatoid; Autoantibodies; Case-Control Stud

2015

Other Studies

3 other studies available for metformin and Lupus Nephritis

ArticleYear
Metformin improves renal injury of MRL/lpr lupus-prone mice via the AMPK/STAT3 pathway.
    Lupus science & medicine, 2022, Volume: 9, Issue:1

    Topics: AMP-Activated Protein Kinases; Animals; Humans; Inflammation; Kidney; Lipopolysaccharides; Lupus Ery

2022
Efficacy of the Combination of Metformin and CTLA4Ig in the (NZB × NZW)F1 Mouse Model of Lupus Nephritis.
    ImmunoHorizons, 2020, 06-15, Volume: 4, Issue:6

    Topics: Abatacept; Animals; Antigens, CD; Autoantibodies; CD4-Positive T-Lymphocytes; CTLA-4 Antigen; Diseas

2020
Piperine ameliorated lupus nephritis by targeting AMPK-mediated activation of NLRP3 inflammasome.
    International immunopharmacology, 2018, Volume: 65

    Topics: Alkaloids; AMP-Activated Protein Kinase Kinases; Animals; Anti-Inflammatory Agents; Benzodioxoles; C

2018
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