metformin has been researched along with Low Bone Density in 7 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have recently demonstrated that the combined treatment between moderate exercise and metformin slows sarcopenia's onset by a mechanism that includes adipose reduction and REDOX regulation." | 8.02 | Metformin and tBHQ Treatment Combined with an Exercise Regime Prevents Osteosarcopenic Obesity in Middle-Aged Wistar Female Rats. ( Hernández-Álvarez, D; Königsberg, M; Lopéz-Cervantes, SP; López-Diazguerrero, NE; Luna-López, A; Mena-Montes, B; Pedraza-Vázquez, G; Sánchez-Garibay, C; Toledo-Pérez, R, 2021) |
| " Recent epidemiologic studies have shown that the fracture rate was decreased in patients treated with metformin, one of the anti-hyperglycemic agents by improving insulin resistance." | 4.85 | [Usefulness of metformin in diabetes-related bone disease]. ( Kanazawa, I, 2009) |
| "Metformin treatment was associated with a higher T-score and a lower odds ratio of osteopenia and osteoporosis, especially in the female population, independent of age, BMI, and eGFR." | 4.12 | Metformin treatment is associated with an increase in bone mineral density in type 2 diabetes mellitus patients in China: A retrospective single center study. ( He, H; Jiang, L; Lee, KO; Li, D; Liu, Q; Ma, J; Sun, J, 2022) |
| " We have recently demonstrated that the combined treatment between moderate exercise and metformin slows sarcopenia's onset by a mechanism that includes adipose reduction and REDOX regulation." | 4.02 | Metformin and tBHQ Treatment Combined with an Exercise Regime Prevents Osteosarcopenic Obesity in Middle-Aged Wistar Female Rats. ( Hernández-Álvarez, D; Königsberg, M; Lopéz-Cervantes, SP; López-Diazguerrero, NE; Luna-López, A; Mena-Montes, B; Pedraza-Vázquez, G; Sánchez-Garibay, C; Toledo-Pérez, R, 2021) |
| "Metformin (Met), an anti-diabetes drug, has also shown therapeutic effects for ovariectomy-induced (OVX) osteoporosis." | 3.91 | Metformin Alleviates the Bone Loss Induced by Ketogenic Diet: An In Vivo Study in Mice. ( Ding, J; Huang, Z; Kong, G; Li, R; Lin, J; Liu, J; Liu, Q; Liu, Y; Wu, X; Xu, X; Yang, Z; Zhu, Q, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, J | 1 |
| Liu, Q | 2 |
| He, H | 1 |
| Jiang, L | 1 |
| Lee, KO | 1 |
| Li, D | 1 |
| Ma, J | 1 |
| Toledo-Pérez, R | 1 |
| Lopéz-Cervantes, SP | 1 |
| Hernández-Álvarez, D | 1 |
| Mena-Montes, B | 1 |
| Pedraza-Vázquez, G | 1 |
| Sánchez-Garibay, C | 1 |
| López-Diazguerrero, NE | 1 |
| Königsberg, M | 1 |
| Luna-López, A | 1 |
| Xu, X | 1 |
| Yang, Z | 1 |
| Liu, Y | 1 |
| Wu, X | 1 |
| Huang, Z | 2 |
| Liu, J | 1 |
| Kong, G | 1 |
| Ding, J | 1 |
| Li, R | 1 |
| Lin, J | 1 |
| Zhu, Q | 1 |
| Schlechte, JA | 1 |
| Hegazy, SK | 1 |
| Kanazawa, I | 1 |
| Kotler, DP | 1 |
1 review available for metformin and Low Bone Density
| Article | Year |
|---|---|
[Usefulness of metformin in diabetes-related bone disease].
Topics: Bone Density; Bone Diseases, Metabolic; Cell Differentiation; Diabetes Mellitus, Type 2; Fractures, | 2009 |
1 trial available for metformin and Low Bone Density
| Article | Year |
|---|---|
Evaluation of the anti-osteoporotic effects of metformin and sitagliptin in postmenopausal diabetic women.
Topics: Absorptiometry, Photon; Aged; Alkaline Phosphatase; Amino Acids; Bone and Bones; Bone Density; Bone | 2015 |
5 other studies available for metformin and Low Bone Density
| Article | Year |
|---|---|
Metformin treatment is associated with an increase in bone mineral density in type 2 diabetes mellitus patients in China: A retrospective single center study.
Topics: Absorptiometry, Photon; Bone Density; Bone Diseases, Metabolic; China; Diabetes Mellitus, Type 2; Fe | 2022 |
Metformin and tBHQ Treatment Combined with an Exercise Regime Prevents Osteosarcopenic Obesity in Middle-Aged Wistar Female Rats.
Topics: Animals; Bone Diseases, Metabolic; Female; Hydroquinones; Metformin; Obesity; Physical Conditioning, | 2021 |
Metformin Alleviates the Bone Loss Induced by Ketogenic Diet: An In Vivo Study in Mice.
Topics: Animals; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Cancellous Bone; Cortical Bone; Die | 2019 |
Update in endocrinology: evidence published in 2012.
Topics: Biliopancreatic Diversion; Bone Density; Bone Density Conservation Agents; Bone Diseases, Metabolic; | 2013 |
Metabolic alterations in HIV lipodystrophy. IAPAC sessions 2001, July 18-19, 2001 - Chicago.
Topics: Acidosis; Anti-HIV Agents; Bone Diseases, Metabolic; Cost-Benefit Analysis; Glucose; Glucose Intoler | 2001 |