metformin has been researched along with Liver Failure in 5 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to assess the incidence of liver failure in association with antidiabetic treatment using pioglitazone vs." | 7.73 | Comparison of pioglitazone with other antidiabetic drugs for associated incidence of liver failure: no evidence of increased risk of liver failure with pioglitazone. ( Iyer, S; Perez, A; Rajagopalan, R, 2005) |
| "The aim of this study was to assess the incidence of liver failure in association with antidiabetic treatment using pioglitazone vs." | 3.73 | Comparison of pioglitazone with other antidiabetic drugs for associated incidence of liver failure: no evidence of increased risk of liver failure with pioglitazone. ( Iyer, S; Perez, A; Rajagopalan, R, 2005) |
| "At baseline, 5." | 2.70 | Evaluation of liver function in type 2 diabetic patients during clinical trials: evidence that rosiglitazone does not cause hepatic dysfunction. ( Freed, MI; Kreider, M; Lebovitz, HE, 2002) |
| "Acute liver failure was defined as acute liver disease and (1) hepatic encephalopathy, (2) prothrombin time prolongation greater than 3 seconds or international normalized ratio greater than 1." | 1.32 | A cohort study of the incidence of serious acute liver injury in diabetic patients treated with hypoglycemic agents. ( Ackerson, L; Chan, KA; Everhart, JE; Gurwitz, JH; Hurley, JS; Martinson, B; Moseley, RH; Platt, R; Selby, JV; Terrault, N; Truman, A, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Regelmann, MO | 1 |
| Goldis, M | 1 |
| Arnon, R | 1 |
| Chan, KA | 1 |
| Truman, A | 1 |
| Gurwitz, JH | 1 |
| Hurley, JS | 1 |
| Martinson, B | 1 |
| Platt, R | 1 |
| Everhart, JE | 1 |
| Moseley, RH | 1 |
| Terrault, N | 1 |
| Ackerson, L | 1 |
| Selby, JV | 1 |
| Rajagopalan, R | 1 |
| Iyer, S | 1 |
| Perez, A | 1 |
| Kluwe, J | 1 |
| Lohse, AW | 1 |
| Lebovitz, HE | 1 |
| Kreider, M | 1 |
| Freed, MI | 1 |
2 reviews available for metformin and Liver Failure
| Article | Year |
|---|---|
New-onset diabetes mellitus after pediatric liver transplantation.
Topics: Albuminuria; Child; Cyclosporine; Diabetes Mellitus; Diabetic Retinopathy; Glucocorticoids; Humans; | 2015 |
[Therapeutic options for nonalcoholic fatty liver disease and steatohepatitis].
Topics: Diet Therapy; Exercise Therapy; Fatty Liver; Fatty Liver, Alcoholic; Humans; Liver Cirrhosis; Liver | 2005 |
1 trial available for metformin and Liver Failure
| Article | Year |
|---|---|
Evaluation of liver function in type 2 diabetic patients during clinical trials: evidence that rosiglitazone does not cause hepatic dysfunction.
Topics: Adult; Aged; Aged, 80 and over; Alanine Transaminase; Diabetes Mellitus, Type 2; Double-Blind Method | 2002 |
2 other studies available for metformin and Liver Failure
| Article | Year |
|---|---|
A cohort study of the incidence of serious acute liver injury in diabetic patients treated with hypoglycemic agents.
Topics: Acute Disease; Adult; Aged; Chemical and Drug Induced Liver Injury; Chromans; Cohort Studies; Female | 2003 |
Comparison of pioglitazone with other antidiabetic drugs for associated incidence of liver failure: no evidence of increased risk of liver failure with pioglitazone.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver In | 2005 |