metformin has been researched along with Liver Diseases in 32 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Liver Diseases: Pathological processes of the LIVER.
Excerpt | Relevance | Reference |
---|---|---|
"Metformin inhibits cyclic AMP generation and activates AMP-activated protein kinase (AMPK), which inhibits the cystic fibrosis transmembrane conductance regulator and Mammalian Target of Rapamycin pathways." | 9.27 | A Randomized Clinical Trial of Metformin to Treat Autosomal Dominant Polycystic Kidney Disease. ( Abebe, KZ; Bae, KT; Hallows, KR; Miskulin, DC; Perrone, RD; Seliger, SL; Watnick, T, 2018) |
"Our findings suggest that metformin might reduce the rates or severity of liver dysfunction in selected high-risk adolescents." | 9.12 | Liver dysfunction in paediatric obesity: a randomized, controlled trial of metformin. ( Freemark, M, 2007) |
"To synthesize data addressing outcomes of metformin use in populations with type 2 diabetes and moderate to severe chronic kidney disease (CKD), congestive heart failure (CHF), or chronic liver disease (CLD) with hepatic impairment." | 8.95 | Clinical Outcomes of Metformin Use in Populations With Chronic Kidney Disease, Congestive Heart Failure, or Chronic Liver Disease: A Systematic Review. ( Cameron, CB; Crowley, MJ; Diamantidis, CJ; Kosinski, AS; McDuffie, JR; Mock, CK; Nagi, A; Stanifer, JW; Tang, S; Wang, X; Williams, JW, 2017) |
"We assessed racial/ethnic disparity in hepatocellular carcinoma (HCC) incidence among men with type 2 diabetes (T2D) but without chronic liver diseases (CLD), and whether metformin use modified the disparity." | 7.91 | Metformin modifies disparity in hepatocellular carcinoma incidence in men with type 2 diabetes but without chronic liver diseases. ( Kuhn, J; Lam, YF; MacCarthy, D; Ramirez, AG; Schmidt, S; Shah, DP; Tenner, L; Wang, CP, 2019) |
"To estimate the incidence of lactic acidosis (LA) and role of metformin in Japanese patients with type 2 diabetes mellitus (T2DM) treated with anti-diabetes drugs." | 7.83 | Epidemiology of lactic acidosis in type 2 diabetes patients with metformin in Japan. ( Chang, CH; Dolin, P; Sakaguchi, M, 2016) |
"In 84% of the cases, type 2 diabetes mellitus has been present before the HCC diagnosis." | 5.36 | Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease. ( Balbi, M; Casarin, P; Donadon, V; Mas, MD; Zanette, G, 2010) |
"GVHD had little effect." | 5.35 | O-glycoside biomarker of apolipoprotein C3: responsiveness to obesity, bariatric surgery, and therapy with metformin, to chronic or severe liver disease and to mortality in severe sepsis and graft vs host disease. ( Bernard, GR; Ely, EW; Harvey, SB; Homoncik, M; Jilma, B; Kasthuri, RS; Kellogg, TA; Lund, TC; Monkkonen, T; Nelsestuen, GL; Swan, T; Verneris, MR; Wilson-Grady, J; Zeisler, H; Zhang, Y, 2009) |
"Metformin inhibits cyclic AMP generation and activates AMP-activated protein kinase (AMPK), which inhibits the cystic fibrosis transmembrane conductance regulator and Mammalian Target of Rapamycin pathways." | 5.27 | A Randomized Clinical Trial of Metformin to Treat Autosomal Dominant Polycystic Kidney Disease. ( Abebe, KZ; Bae, KT; Hallows, KR; Miskulin, DC; Perrone, RD; Seliger, SL; Watnick, T, 2018) |
"Our findings suggest that metformin might reduce the rates or severity of liver dysfunction in selected high-risk adolescents." | 5.12 | Liver dysfunction in paediatric obesity: a randomized, controlled trial of metformin. ( Freemark, M, 2007) |
"To synthesize data addressing outcomes of metformin use in populations with type 2 diabetes and moderate to severe chronic kidney disease (CKD), congestive heart failure (CHF), or chronic liver disease (CLD) with hepatic impairment." | 4.95 | Clinical Outcomes of Metformin Use in Populations With Chronic Kidney Disease, Congestive Heart Failure, or Chronic Liver Disease: A Systematic Review. ( Cameron, CB; Crowley, MJ; Diamantidis, CJ; Kosinski, AS; McDuffie, JR; Mock, CK; Nagi, A; Stanifer, JW; Tang, S; Wang, X; Williams, JW, 2017) |
"The FDA approved 'label' for metformin lists hepatic insufficiency as a risk for lactic acidosis." | 3.96 | The safety and pharmacokinetics of metformin in patients with chronic liver disease. ( Braithwaite, HE; Carland, JE; Cheng, TS; Danta, M; Day, RO; Graham, GG; Greenfield, JR; Kumar, SS; Liu, Z; Smith, FC; Stocker, SL; Williams, KM, 2020) |
"We assessed racial/ethnic disparity in hepatocellular carcinoma (HCC) incidence among men with type 2 diabetes (T2D) but without chronic liver diseases (CLD), and whether metformin use modified the disparity." | 3.91 | Metformin modifies disparity in hepatocellular carcinoma incidence in men with type 2 diabetes but without chronic liver diseases. ( Kuhn, J; Lam, YF; MacCarthy, D; Ramirez, AG; Schmidt, S; Shah, DP; Tenner, L; Wang, CP, 2019) |
"To estimate the incidence of lactic acidosis (LA) and role of metformin in Japanese patients with type 2 diabetes mellitus (T2DM) treated with anti-diabetes drugs." | 3.83 | Epidemiology of lactic acidosis in type 2 diabetes patients with metformin in Japan. ( Chang, CH; Dolin, P; Sakaguchi, M, 2016) |
"Treatment with metformin is occasionally associated with the development of severe lactic acidosis." | 3.69 | Contraindications to metformin therapy in patients with NIDDM. ( Bosman, D; Krentz, AJ; Sulkin, TV, 1997) |
"Metformin treatment showed either small mean increases or decreases." | 2.71 | Changes in liver tests during 1-year treatment of patients with Type 2 diabetes with pioglitazone, metformin or gliclazide. ( Belcher, G; Schernthaner, G, 2005) |
"Patients with type 2 diabetes have an increased risk of chronic liver disease (CLD) such as non-alcoholic fatty liver disease and steatohepatitis and about one-third of cirrhotic patients have diabetes." | 2.50 | Pharmacokinetic and toxicological considerations for the treatment of diabetes in patients with liver disease. ( Scheen, AJ, 2014) |
"Physiologically based pharmacokinetic (PBPK) modelling and simulation enable researchers to overcome practical limitations for clinical trials on special populations." | 1.46 | Physiologically Based Pharmacokinetic Modelling and Prediction of Metformin Pharmacokinetics in Renal/Hepatic-Impaired Young Adults and Elderly Populations. ( Chung, H; Chung, JY; Rhee, SJ; Yi, S; Yu, KS, 2017) |
"Metformin is an antidiabetic agent that decreases hyperglycemia by different pathways than insulin; therefore, we asked whether metformin affects postburn ER stress and hepatic metabolism." | 1.39 | Effects of metformin on burn-induced hepatic endoplasmic reticulum stress in male rats. ( Arno, A; Herndon, DN; Hiyama, Y; Jeschke, MG; Kraft, R; Marshall, AH; Qa'aty, N, 2013) |
"In 84% of the cases, type 2 diabetes mellitus has been present before the HCC diagnosis." | 1.36 | Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease. ( Balbi, M; Casarin, P; Donadon, V; Mas, MD; Zanette, G, 2010) |
"GVHD had little effect." | 1.35 | O-glycoside biomarker of apolipoprotein C3: responsiveness to obesity, bariatric surgery, and therapy with metformin, to chronic or severe liver disease and to mortality in severe sepsis and graft vs host disease. ( Bernard, GR; Ely, EW; Harvey, SB; Homoncik, M; Jilma, B; Kasthuri, RS; Kellogg, TA; Lund, TC; Monkkonen, T; Nelsestuen, GL; Swan, T; Verneris, MR; Wilson-Grady, J; Zeisler, H; Zhang, Y, 2009) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (9.38) | 18.7374 |
1990's | 1 (3.13) | 18.2507 |
2000's | 6 (18.75) | 29.6817 |
2010's | 15 (46.88) | 24.3611 |
2020's | 7 (21.88) | 2.80 |
Authors | Studies |
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Dare, A | 1 |
Channa, ML | 1 |
Nadar, A | 1 |
Song, H | 3 |
Zhang, X | 5 |
Zhai, R | 1 |
Liang, H | 1 |
Song, G | 1 |
Yuan, Y | 1 |
Xu, Y | 2 |
Yan, Y | 1 |
Qiu, L | 1 |
Sun, T | 1 |
Ajiboye, BO | 1 |
Dada, S | 1 |
Fatoba, HO | 1 |
Lawal, OE | 1 |
Oyeniran, OH | 1 |
Adetuyi, OY | 1 |
Olatunde, A | 1 |
Taher, M | 1 |
Khotib, J | 1 |
Susanti, D | 1 |
Oyinloye, BE | 1 |
Smith, FC | 1 |
Stocker, SL | 1 |
Danta, M | 1 |
Carland, JE | 1 |
Kumar, SS | 1 |
Liu, Z | 3 |
Greenfield, JR | 1 |
Braithwaite, HE | 1 |
Cheng, TS | 1 |
Graham, GG | 1 |
Williams, KM | 1 |
Day, RO | 1 |
Bao, S | 1 |
Wu, YL | 1 |
Wang, X | 7 |
Han, S | 1 |
Cho, S | 1 |
Ao, W | 1 |
Nan, JX | 1 |
Nguépy Keubo, FR | 1 |
Mboua, PC | 1 |
Djifack Tadongfack, T | 1 |
Fokouong Tchoffo, E | 1 |
Tasson Tatang, C | 1 |
Ide Zeuna, J | 1 |
Noupoue, EM | 1 |
Tsoplifack, CB | 1 |
Folefack, GO | 1 |
Kettani, M | 1 |
Bandelier, P | 1 |
Huo, J | 1 |
Li, H | 4 |
Yu, D | 1 |
Arulsamy, N | 1 |
AlAbbad, S | 1 |
Sardot, T | 1 |
Lekashvili, O | 1 |
Decato, D | 1 |
Lelj, F | 1 |
Alexander Ross, JB | 1 |
Rosenberg, E | 1 |
Nazir, H | 1 |
Muthuswamy, N | 1 |
Louis, C | 1 |
Jose, S | 1 |
Prakash, J | 1 |
Buan, MEM | 1 |
Flox, C | 1 |
Chavan, S | 1 |
Shi, X | 1 |
Kauranen, P | 1 |
Kallio, T | 1 |
Maia, G | 1 |
Tammeveski, K | 1 |
Lymperopoulos, N | 1 |
Carcadea, E | 1 |
Veziroglu, E | 1 |
Iranzo, A | 1 |
M Kannan, A | 1 |
Arunamata, A | 1 |
Tacy, TA | 1 |
Kache, S | 1 |
Mainwaring, RD | 1 |
Ma, M | 1 |
Maeda, K | 1 |
Punn, R | 1 |
Noguchi, S | 1 |
Hahn, S | 3 |
Iwasa, Y | 3 |
Ling, J | 2 |
Voccio, JP | 2 |
Kim, Y | 3 |
Song, J | 3 |
Bascuñán, J | 2 |
Chu, Y | 1 |
Tomita, M | 1 |
Cazorla, M | 1 |
Herrera, E | 1 |
Palomeque, E | 1 |
Saud, N | 1 |
Hoplock, LB | 1 |
Lobchuk, MM | 1 |
Lemoine, J | 1 |
Li, X | 10 |
Henson, MA | 1 |
Unsihuay, D | 1 |
Qiu, J | 2 |
Swaroop, S | 1 |
Nagornov, KO | 1 |
Kozhinov, AN | 1 |
Tsybin, YO | 1 |
Kuang, S | 1 |
Laskin, J | 1 |
Zin, NNINM | 1 |
Mohamad, MN | 1 |
Roslan, K | 1 |
Abdul Wafi, S | 1 |
Abdul Moin, NI | 1 |
Alias, A | 1 |
Zakaria, Y | 1 |
Abu-Bakar, N | 1 |
Naveed, A | 1 |
Jilani, K | 1 |
Siddique, AB | 1 |
Akbar, M | 1 |
Riaz, M | 1 |
Mushtaq, Z | 1 |
Sikandar, M | 1 |
Ilyas, S | 1 |
Bibi, I | 1 |
Asghar, A | 1 |
Rasool, G | 1 |
Irfan, M | 1 |
Li, XY | 1 |
Zhao, S | 1 |
Fan, XH | 1 |
Chen, KP | 1 |
Hua, W | 1 |
Liu, ZM | 1 |
Xue, XD | 1 |
Zhou, B | 1 |
Zhang, S | 2 |
Xing, YL | 1 |
Chen, MA | 1 |
Sun, Y | 1 |
Neradilek, MB | 1 |
Wu, XT | 1 |
Zhang, D | 2 |
Huang, W | 1 |
Cui, Y | 1 |
Yang, QQ | 1 |
Li, HW | 1 |
Zhao, XQ | 1 |
Hossein Rashidi, B | 1 |
Tarafdari, A | 1 |
Ghazimirsaeed, ST | 1 |
Shahrokh Tehraninezhad, E | 1 |
Keikha, F | 1 |
Eslami, B | 1 |
Ghazimirsaeed, SM | 1 |
Jafarabadi, M | 1 |
Silvani, Y | 1 |
Lovita, AND | 1 |
Maharani, A | 1 |
Wiyasa, IWA | 1 |
Sujuti, H | 1 |
Ratnawati, R | 1 |
Raras, TYM | 1 |
Lemin, AS | 1 |
Rahman, MM | 1 |
Pangarah, CA | 1 |
Kiyu, A | 1 |
Zeng, C | 2 |
Du, H | 1 |
Lin, D | 1 |
Jalan, D | 1 |
Rubagumya, F | 1 |
Hopman, WM | 1 |
Vanderpuye, V | 1 |
Lopes, G | 1 |
Seruga, B | 1 |
Booth, CM | 1 |
Berry, S | 1 |
Hammad, N | 1 |
Sajo, EA | 1 |
Okunade, KS | 1 |
Olorunfemi, G | 1 |
Rabiu, KA | 1 |
Anorlu, RI | 1 |
Xu, C | 2 |
Xiang, Y | 1 |
Xu, X | 1 |
Zhou, L | 2 |
Dong, X | 1 |
Tang, S | 2 |
Gao, XC | 1 |
Wei, CH | 1 |
Zhang, RG | 1 |
Cai, Q | 1 |
He, Y | 1 |
Tong, F | 1 |
Dong, JH | 1 |
Wu, G | 1 |
Dong, XR | 1 |
Tang, X | 1 |
Tao, F | 1 |
Xiang, W | 1 |
Zhao, Y | 2 |
Jin, L | 1 |
Tao, H | 1 |
Lei, Y | 1 |
Gan, H | 1 |
Huang, Y | 1 |
Chen, Y | 3 |
Chen, L | 3 |
Shan, A | 1 |
Zhao, H | 2 |
Wu, M | 2 |
Ma, Q | 1 |
Wang, J | 4 |
Zhang, E | 1 |
Zhang, J | 3 |
Li, Y | 5 |
Xue, F | 1 |
Deng, L | 1 |
Liu, L | 2 |
Yan, Z | 2 |
Wang, Y | 2 |
Meng, J | 1 |
Chen, G | 2 |
Anastassiadou, M | 1 |
Bernasconi, G | 1 |
Brancato, A | 1 |
Carrasco Cabrera, L | 1 |
Greco, L | 1 |
Jarrah, S | 1 |
Kazocina, A | 1 |
Leuschner, R | 1 |
Magrans, JO | 1 |
Miron, I | 1 |
Nave, S | 1 |
Pedersen, R | 1 |
Reich, H | 1 |
Rojas, A | 1 |
Sacchi, A | 1 |
Santos, M | 1 |
Theobald, A | 1 |
Vagenende, B | 1 |
Verani, A | 1 |
Du, L | 1 |
Liu, X | 1 |
Ren, Y | 1 |
Li, J | 7 |
Li, P | 1 |
Jiao, Q | 1 |
Meng, P | 1 |
Wang, F | 2 |
Wang, YS | 1 |
Wang, C | 3 |
Zhou, X | 2 |
Wang, W | 1 |
Wang, S | 2 |
Hou, J | 1 |
Zhang, A | 1 |
Lv, B | 1 |
Gao, C | 1 |
Pang, D | 1 |
Lu, K | 1 |
Ahmad, NH | 1 |
Wang, L | 1 |
Zhu, J | 2 |
Zhang, L | 2 |
Zhuang, T | 1 |
Tu, J | 1 |
Zhao, Z | 1 |
Qu, Y | 1 |
Yao, H | 1 |
Lee, DF | 1 |
Shen, J | 3 |
Wen, L | 1 |
Huang, G | 2 |
Xie, X | 1 |
Zhao, Q | 1 |
Hu, W | 1 |
Zhang, Y | 5 |
Wu, X | 1 |
Lu, J | 2 |
Li, M | 1 |
Li, W | 2 |
Wu, W | 1 |
Du, F | 1 |
Ji, H | 1 |
Yang, X | 2 |
Xu, Z | 1 |
Wan, L | 1 |
Wen, Q | 1 |
Cho, CH | 1 |
Zou, C | 1 |
Xiao, Z | 1 |
Liao, J | 1 |
Su, X | 1 |
Bi, Z | 1 |
Su, Q | 1 |
Huang, H | 1 |
Wei, Y | 2 |
Gao, Y | 2 |
Na, KJ | 1 |
Choi, H | 1 |
Oh, HR | 1 |
Kim, YH | 1 |
Lee, SB | 1 |
Jung, YJ | 1 |
Koh, J | 1 |
Park, S | 1 |
Lee, HJ | 1 |
Jeon, YK | 1 |
Chung, DH | 1 |
Paeng, JC | 1 |
Park, IK | 1 |
Kang, CH | 1 |
Cheon, GJ | 1 |
Kang, KW | 1 |
Lee, DS | 1 |
Kim, YT | 1 |
Pajuelo-Lozano, N | 1 |
Alcalá, S | 1 |
Sainz, B | 1 |
Perona, R | 1 |
Sanchez-Perez, I | 1 |
Logotheti, S | 1 |
Marquardt, S | 1 |
Gupta, SK | 1 |
Richter, C | 1 |
Edelhäuser, BAH | 1 |
Engelmann, D | 1 |
Brenmoehl, J | 1 |
Söhnchen, C | 1 |
Murr, N | 1 |
Alpers, M | 1 |
Singh, KP | 1 |
Wolkenhauer, O | 1 |
Heckl, D | 1 |
Spitschak, A | 1 |
Pützer, BM | 1 |
Liao, Y | 1 |
Cheng, J | 1 |
Kong, X | 1 |
Li, S | 1 |
Zhang, M | 4 |
Zhang, H | 2 |
Yang, T | 2 |
Dong, Y | 1 |
Yuan, Z | 1 |
Cao, J | 1 |
Zheng, Y | 1 |
Luo, Z | 1 |
Mei, Z | 1 |
Yao, Y | 1 |
Liang, C | 1 |
Yang, H | 1 |
Song, Y | 1 |
Yu, K | 1 |
Zhu, C | 1 |
Huang, Z | 1 |
Qian, J | 1 |
Ge, J | 1 |
Hu, J | 2 |
Wang, H | 2 |
Liu, Y | 4 |
Mi, Y | 1 |
Kong, H | 1 |
Xi, D | 1 |
Yan, W | 1 |
Luo, X | 1 |
Ning, Q | 1 |
Chang, X | 2 |
Zhang, T | 2 |
Wang, Q | 2 |
Rathore, MG | 1 |
Reddy, K | 1 |
Chen, H | 1 |
Shin, SH | 1 |
Ma, WY | 1 |
Bode, AM | 1 |
Dong, Z | 1 |
Mu, W | 1 |
Liu, C | 3 |
Gao, F | 1 |
Qi, Y | 1 |
Lu, H | 1 |
Cai, X | 1 |
Ji, RY | 1 |
Hou, Y | 3 |
Tian, J | 2 |
Shi, Y | 1 |
Ying, S | 1 |
Tan, M | 1 |
Feng, G | 1 |
Kuang, Y | 1 |
Chen, D | 1 |
Wu, D | 3 |
Zhu, ZQ | 1 |
Tang, HX | 1 |
Shi, ZE | 1 |
Kang, J | 1 |
Liu, Q | 1 |
Qi, J | 2 |
Mu, J | 1 |
Cong, Z | 1 |
Chen, S | 2 |
Fu, D | 1 |
Li, Z | 2 |
Celestrin, CP | 1 |
Rocha, GZ | 1 |
Stein, AM | 1 |
Guadagnini, D | 1 |
Tadelle, RM | 1 |
Saad, MJA | 1 |
Oliveira, AG | 1 |
Bianconi, V | 1 |
Bronzo, P | 1 |
Banach, M | 1 |
Sahebkar, A | 1 |
Mannarino, MR | 1 |
Pirro, M | 1 |
Patsourakos, NG | 1 |
Kouvari, M | 1 |
Kotidis, A | 1 |
Kalantzi, KI | 1 |
Tsoumani, ME | 1 |
Anastasiadis, F | 1 |
Andronikos, P | 1 |
Aslanidou, T | 1 |
Efraimidis, P | 1 |
Georgiopoulos, A | 1 |
Gerakiou, K | 1 |
Grigoriadou-Skouta, E | 1 |
Grigoropoulos, P | 1 |
Hatzopoulos, D | 1 |
Kartalis, A | 1 |
Lyras, A | 1 |
Markatos, G | 1 |
Mikrogeorgiou, A | 1 |
Myroforou, I | 1 |
Orkopoulos, A | 1 |
Pavlidis, P | 1 |
Petras, C | 1 |
Riga, M | 1 |
Skouloudi, M | 1 |
Smyrnioudis, N | 1 |
Thomaidis, K | 1 |
Tsikouri, GE | 1 |
Tsikouris, EI | 1 |
Zisimos, K | 1 |
Vavoulis, P | 1 |
Vitali, MG | 1 |
Vitsas, G | 1 |
Vogiatzidis, C | 1 |
Chantanis, S | 1 |
Fousas, S | 1 |
Panagiotakos, DB | 1 |
Tselepis, AD | 1 |
Jungen, C | 1 |
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Eickholt, C | 1 |
Scherschel, K | 1 |
Kuklik, P | 1 |
Klatt, N | 1 |
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Akbulak, RO | 1 |
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Szczepanik, M | 1 |
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Chen, W | 2 |
Hu, X | 1 |
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Wei, H | 1 |
Wang, Z | 1 |
Gurzu, S | 1 |
Jung, I | 1 |
Sugimura, H | 2 |
Stefan-van Staden, RI | 1 |
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Natsume, H | 1 |
Iwashita, Y | 1 |
Szodorai, R | 1 |
Szederjesi, J | 1 |
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Ehsanbakhsh, Z | 1 |
Validad, MH | 1 |
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Mets-Halgrimson, R | 1 |
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Zeid, JL | 1 |
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Rahmani, B | 1 |
Araujo-Castillo, RV | 1 |
Culquichicón, C | 1 |
Solis Condor, R | 1 |
Efendi, F | 1 |
Sebayang, SK | 1 |
Astutik, E | 1 |
Hadisuyatmana, S | 1 |
Has, EMM | 1 |
Kuswanto, H | 1 |
Foroutan, T | 1 |
Ahmadi, F | 1 |
Moayer, F | 1 |
Khalvati, S | 1 |
Zhang, Q | 2 |
Lyu, Y | 1 |
Huang, J | 1 |
Yu, N | 1 |
Wen, Z | 1 |
Hou, H | 1 |
Zhao, T | 1 |
Gupta, A | 1 |
Khosla, N | 1 |
Govindasamy, V | 1 |
Saini, A | 1 |
Annapurna, K | 1 |
Dhakate, SR | 1 |
Akkaya, Ö | 1 |
Chandgude, AL | 1 |
Dömling, A | 1 |
Harnett, J | 1 |
Oakes, K | 1 |
Carè, J | 1 |
Leach, M | 1 |
Brown, D | 1 |
Cramer, H | 1 |
Pinder, TA | 1 |
Steel, A | 1 |
Anheyer, D | 1 |
Cantu, J | 1 |
Valle, J | 1 |
Flores, K | 1 |
Gonzalez, D | 1 |
Valdes, C | 1 |
Lopez, J | 1 |
Padilla, V | 1 |
Alcoutlabi, M | 1 |
Parsons, J | 1 |
Núñez, K | 1 |
Hamed, M | 1 |
Fort, D | 1 |
Bruce, D | 1 |
Thevenot, P | 1 |
Cohen, A | 1 |
Weber, P | 1 |
Menezes, AMB | 1 |
Gonçalves, H | 1 |
Perez-Padilla, R | 1 |
Jarvis, D | 1 |
de Oliveira, PD | 1 |
Wehrmeister, FC | 1 |
Mir, S | 1 |
Wong, J | 1 |
Ryan, CM | 1 |
Bellingham, G | 1 |
Singh, M | 2 |
Waseem, R | 1 |
Eckert, DJ | 1 |
Chung, F | 1 |
Hegde, H | 1 |
Shimpi, N | 1 |
Panny, A | 1 |
Glurich, I | 1 |
Christie, P | 1 |
Acharya, A | 1 |
English, KL | 1 |
Downs, M | 1 |
Goetchius, E | 1 |
Buxton, R | 1 |
Ryder, JW | 1 |
Ploutz-Snyder, R | 1 |
Guilliams, M | 1 |
Scott, JM | 1 |
Ploutz-Snyder, LL | 1 |
Martens, C | 1 |
Goplen, FK | 1 |
Aasen, T | 1 |
Gjestad, R | 1 |
Nordfalk, KF | 1 |
Nordahl, SHG | 1 |
Inoue, T | 1 |
Soshi, S | 1 |
Kubota, M | 1 |
Marumo, K | 1 |
Mortensen, NP | 1 |
Caffaro, MM | 1 |
Patel, PR | 2 |
Uddin, MJ | 1 |
Aravamudhan, S | 1 |
Sumner, SJ | 1 |
Fennell, TR | 1 |
Gal, RL | 1 |
Cohen, NJ | 1 |
Kruger, D | 1 |
Beck, RW | 1 |
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Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Prevalence of NAFLD and Correlation With Its Main Risk Factors Among Egyptian Multicenter National Study[NCT04081571] | 1,080 participants (Anticipated) | Observational | 2019-04-01 | Recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
6 reviews available for metformin and Liver Diseases
Article | Year |
---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Hepatoprotective activity of metformin: A new mission for an old drug?
Topics: Animals; Cytoprotection; Humans; Liver; Liver Diseases; Metformin; Xenobiotics | 2019 |
Pharmacokinetic and toxicological considerations for the treatment of diabetes in patients with liver disease.
Topics: Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Hepatic Insufficiency; Humans; Hypogl | 2014 |
Clinical Outcomes of Metformin Use in Populations With Chronic Kidney Disease, Congestive Heart Failure, or Chronic Liver Disease: A Systematic Review.
Topics: Cause of Death; Chronic Disease; Contraindications; Diabetes Mellitus, Type 2; Heart Failure; Humans | 2017 |
Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management.
Topics: Bariatric Surgery; Biomarkers; Biopsy; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type | 2009 |
Glucose tolerance tests in the clinical picture of chronic liver diseases.
Topics: Adolescent; Adult; Age Factors; Aged; Alanine Transaminase; Aspartate Aminotransferases; Body Weight | 1975 |
8 trials available for metformin and Liver Diseases
Article | Year |
---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Endocannabinoid receptor blockade reduces alanine aminotransferase in polycystic ovary syndrome independent of weight loss.
Topics: Alanine Transaminase; Anti-Obesity Agents; Body Mass Index; Cannabinoid Receptor Antagonists; Case-C | 2017 |
A Randomized Clinical Trial of Metformin to Treat Autosomal Dominant Polycystic Kidney Disease.
Topics: Adolescent; Adult; Clinical Trials, Phase II as Topic; Cysts; Disease Progression; Dose-Response Rel | 2018 |
Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.
Topics: Aged; Berberine; Blood Glucose; Cell Line; Diabetes Mellitus, Type 2; Female; Gene Expression; Human | 2010 |
Changes in liver tests during 1-year treatment of patients with Type 2 diabetes with pioglitazone, metformin or gliclazide.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Gliclazide; Glycated He | 2005 |
Liver dysfunction in paediatric obesity: a randomized, controlled trial of metformin.
Topics: Adolescent; Alanine Transaminase; Aspartate Aminotransferases; Colorimetry; Diabetes Mellitus, Type | 2007 |
Liver scan in hyperlipoproteinemia.
Topics: Adult; Aged; Aspartate Aminotransferases; Blood Protein Disorders; Blood Protein Electrophoresis; Ch | 1974 |
HB419 (glibenclamide) in the treatment of diabetes mellitus.
Topics: Adult; Age Factors; Aged; Biguanides; Chlorpropamide; Clinical Trials as Topic; Diabetes Complicatio | 1969 |
19 other studies available for metformin and Liver Diseases
Article | Year |
---|---|
L-ergothioneine and metformin alleviates liver injury in experimental type-2 diabetic rats via reduction of oxidative stress, inflammation, and hypertriglyceridemia.
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Therapy, Combina | 2021 |
Metformin attenuated sepsis-associated liver injury and inflammatory response in aged mice.
Topics: Aging; Animals; Inflammation; Lipopolysaccharides; Liver; Liver Diseases; Male; Metformin; Mice; Mic | 2022 |
Dalbergiella welwitschia (Baker) Baker f. alkaloid-rich extracts attenuate liver damage in streptozotocin-induced diabetic rats.
Topics: Alkaloids; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Hypoglycemic Agents | 2023 |
The safety and pharmacokinetics of metformin in patients with chronic liver disease.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Chronic Disease; Comorbidity; Cross-Sectional Stud | 2020 |
Agriophyllum oligosaccharides ameliorate hepatic injury in type 2 diabetic db/db mice targeting INS-R/IRS-2/PI3K/AKT/PPAR-γ/Glut4 signal pathway.
Topics: Animals; Biomarkers; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Type 2; Disease Models, A | 2020 |
Metformin slows liver cyst formation and fibrosis in experimental model of polycystic liver disease.
Topics: AMP-Activated Protein Kinases; Animals; Cell Proliferation; Cysts; Disease Progression; Enzyme Activ | 2021 |
Physiologically Based Pharmacokinetic Modelling and Prediction of Metformin Pharmacokinetics in Renal/Hepatic-Impaired Young Adults and Elderly Populations.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Computer Simulation; Female; Humans; Kidney Diseases; L | 2017 |
Activation of the Glutathione Peroxidase by Metformin in the Bile-duct Ligation induced Liver Injury: In vivo Combined with Molecular Docking Studies.
Topics: Animals; Bile Ducts; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione Peroxidas | 2018 |
Effects of in utero androgen excess and metformin treatment on hepatic functions.
Topics: Animals; Female; Hyperandrogenism; Hypoglycemic Agents; Insulin Resistance; Lipids; Liver; Liver Dis | 2019 |
Metformin modifies disparity in hepatocellular carcinoma incidence in men with type 2 diabetes but without chronic liver diseases.
Topics: Aged; Carcinoma, Hepatocellular; Comorbidity; Diabetes Mellitus, Type 2; Female; Healthcare Disparit | 2019 |
Noninsulin Antidiabetic Drugs for Patients with Type 2 Diabetes Mellitus: Are We Respecting Their Contraindications?
Topics: Adult; Aged; Aged, 80 and over; Comorbidity; Cross-Sectional Studies; Diabetes Complications; Diabet | 2016 |
Epidemiology of lactic acidosis in type 2 diabetes patients with metformin in Japan.
Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Cohort Studies; Databases, Factual; Diabetes Mellitus, Ty | 2016 |
Unusual glycogenic hepatopathy causing abnormal liver enzymes in a morbidly obese adolescent with well-controlled type 2 diabetes: resolved after A1c was normalized by metformin.
Topics: Adolescent; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Liver Diseases; Male; Metformin; | 2016 |
O-glycoside biomarker of apolipoprotein C3: responsiveness to obesity, bariatric surgery, and therapy with metformin, to chronic or severe liver disease and to mortality in severe sepsis and graft vs host disease.
Topics: Adult; Aged; Apolipoprotein C-III; Bariatric Surgery; Biomarkers; Diabetes Mellitus; Female; Glycosi | 2009 |
Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease.
Topics: Adult; Aged; Carcinoma, Hepatocellular; Case-Control Studies; Chronic Disease; Diabetes Mellitus, Ty | 2010 |
Effects of metformin on burn-induced hepatic endoplasmic reticulum stress in male rats.
Topics: Alanine Transaminase; Albumins; Animals; Endoplasmic Reticulum Stress; Fatty Acids; Gene Expression | 2013 |
Metformin-associated lactic acidosis in a patient with liver disease.
Topics: Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Fatal Outcome; Humans; Hypoglycemic Agents; Live | 2003 |
Contraindications to metformin therapy in patients with NIDDM.
Topics: Acidosis, Lactic; Alcoholism; Contraindications; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; D | 1997 |
Contraindications to metformin therapy in patients with Type 2 diabetes--a population-based study of adherence to prescribing guidelines.
Topics: Cohort Studies; Contraindications; Databases as Topic; Diabetes Mellitus, Type 2; Diabetic Nephropat | 2001 |