metformin has been researched along with Laryngeal Neoplasms in 4 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Laryngeal Neoplasms: Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin is an oral anti-hyperglycemic agent used to treat type 2 diabetes mellitus (DM)." | 1.46 | Metformin Prevents the Progression of Dysplastic Mucosa of the Head and Neck to Carcinoma in Nondiabetic Patients. ( Blitzer, A; Lerner, MZ; Mor, N; Paek, H; Strome, M, 2017) |
| "Metformin use has been linked to improved cancer outcomes." | 1.40 | Association between metformin use and improved survival in patients with laryngeal squamous cell carcinoma. ( Hamblin, JS; Kubik, MW; Myers, JN; Sandulache, VC; Skinner, HD; Zevallos, JP, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, CY | 1 |
| Li, XM | 1 |
| Shan, S | 1 |
| Jia, LF | 1 |
| Huang, ZL | 1 |
| Ogunsakin, A | 1 |
| Infield, J | 1 |
| Zuber, J | 1 |
| Solomon, SS | 1 |
| Sandulache, VC | 1 |
| Hamblin, JS | 1 |
| Skinner, HD | 1 |
| Kubik, MW | 1 |
| Myers, JN | 1 |
| Zevallos, JP | 1 |
| Lerner, MZ | 1 |
| Mor, N | 1 |
| Paek, H | 1 |
| Blitzer, A | 1 |
| Strome, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study of Metformin (MF) IN HNSCC (Head and Neck Squamous Cell Carcinoma) as Window Trial Design in Operable HNSCC, to Investigate the Effects of MF, Tumor Genotype and MF Genotype Interactions, on Tumor Metabolism and Anoikis[NCT02402348] | Early Phase 1 | 3 participants (Actual) | Interventional | 2014-12-31 | Terminated (stopped due to Funding not available, PI left institution) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for metformin and Laryngeal Neoplasms
| Article | Year |
|---|---|
[Metformin's effect on 5-fluorouracil,cisplatin,paclitaxel in laryngocarcinoma Hep-2 cells].
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cisplatin; Fluorouracil; Hum | 2017 |
Metformin Associated With Improved Outcomes in Diabetic Patients With Laryngeal and Oropharyngeal Carcinoma.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Diabetes Mellitus; Hospitals, Veterans; Hypoglycemi | 2018 |
Association between metformin use and improved survival in patients with laryngeal squamous cell carcinoma.
Topics: Aged; Carcinoma, Squamous Cell; Diabetes Mellitus; Disease-Free Survival; Follow-Up Studies; Humans; | 2014 |
Metformin Prevents the Progression of Dysplastic Mucosa of the Head and Neck to Carcinoma in Nondiabetic Patients.
Topics: Aged; Carcinoma, Squamous Cell; Disease Progression; Female; Glottis; Head and Neck Neoplasms; Human | 2017 |