metformin has been researched along with Lactic Acidosis in 589 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin-treated patients may experience severe hyperlactatemia or lactic acidosis (LA)." | 9.41 | Metformin's Role in Hyperlactatemia and Lactic Acidosis in ICU Patients: A Systematic Review. ( Fuster, DG; Moser, M; Mueller, L; Prazak, J; Schefold, JC; Zuercher, P, 2023) |
| "Metformin-associated lactic acidosis is a well-described and commonly encountered condition associated with significant morbidity and mortality." | 9.41 | Expanding the evidence for managing metformin poisoning to support decision-making. ( Ghannoum, M; Roberts, DM, 2023) |
| "Lactic acidosis is a potential adverse event related to metformin therapy." | 9.41 | [Acute Renal Failure, Lactic Acidosis, and Metformin: Two Case Reports and Literature Review]. ( Cesaro, A; Del Piano, C; Del Piano, D; Diglio, A; Faggian, A; Faggian, G; Faggian, R; Salzano, M; Vitagliano, A, 2023) |
| " Moreover, MET-associated lactic acidosis (MALA) needs to be considered and the incidence of MALA in patients with type 2 DM-TB coinfection remains unknown." | 9.27 | A case risk study of lactic acidosis risk by metformin use in type 2 diabetes mellitus tuberculosis coinfection patients. ( Mertaniasih, NM; Novita, BD; Pranoto, A; Soediono, EI, 2018) |
| "Metformin-associated lactic acidosis (MALA) is a severe complication of drug administration with significant morbidity and mortality." | 9.24 | Metformin-Associated Lactic Acidosis Undergoing Renal Replacement Therapy in Intensive Care Units: A Five-Million Population-Based Study in the North-West of Italy. ( Amore, A; Berto, M; Berutti, S; Boero, R; Calabrese, G; Campo, A; Cantaluppi, V; Carpani, P; Comune, L; Consiglio, V; David, P; Filiberti, O; Gherzi, M; Guarena, C; Inguaggiato, P; Manes, M; Marciello, A; Mariano, F; Marino, A; Martina, G; Pozzato, M; Roscini, E; Serra, A; Stramignoni, E; Todini, V; Turello, E; Vio, P, 2017) |
| "Metformin, a molecule belonging to the biguanide family, represents one of the most commonly prescribed medications for the treatment of diabetes mellitus in the world." | 9.22 | Metformin: When Should We Fear Lactic Acidosis? ( Di Mauro, S; Filippello, A; Malaguarnera, R; Piro, S; Purrello, F; Scamporrino, A, 2022) |
| "Metformin poisoning with lactic acidosis is an uncommon yet clinically serious condition related to the inhibition of normal aerobic metabolism." | 9.22 | Continuous extracorporeal clearance in metformin-associated lactic acidosis and metformin-induced lactic acidosis: a systematic review. ( Correia, MS; Horowitz, BZ, 2022) |
| " However, if used in excessive doses for patients with kidney disease, it will be contraindicated with side effects such as lactic acidosis." | 9.22 | Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease. ( Rahman, F; Tuba, S, 2022) |
| "Metformin-associated lactic acidosis (MALA) may occur after acute metformin overdose, or from therapeutic use in patients with renal compromise." | 9.05 | Do Patients Die with or from Metformin-Associated Lactic Acidosis (MALA)? Systematic Review and Meta-analysis of pH and Lactate as Predictors of Mortality in MALA. ( Benabbas, R; Blumenberg, A; Jeng, A; Sinert, R; Wiener, SW, 2020) |
| "Metformin-associated lactic acidosis (MALA) is a rare adverse effect that has significant morbidity and mortality." | 9.05 | Osmolar-gap in the setting of metformin-associated lactic acidosis: Case report and a literature review highlighting an apparently unusual association. ( Alamin, M; Elshafei, MN; Mohamed, MFH, 2020) |
| "There is increasing evidence to suggest that therapeutic doses of metformin are unlikely to cause lactic acidosis." | 9.01 | The Association between Metformin Therapy and Lactic Acidosis. ( Duffull, SB; Kuan, IHS; Savage, RL; Walker, RJ; Wright, DFB, 2019) |
| "The current practice concerning timing, mode, and dose of renal replacement therapy (RRT) in patients with metformin-associated lactic acidosis (MALA) with renal failure remains unknown." | 8.95 | Serum lactate level and mortality in metformin-associated lactic acidosis requiring renal replacement therapy: a systematic review of case reports and case series. ( Kuo, CC; Ting, IW; Tsai, CW; Wu, JY; Yeh, HC, 2017) |
| "Metformin-associated lactic acidosis (MALA) is a rare but potentially fatal condition that can easily be avoided." | 8.95 | [Metformin-associated lactic acidosis: an insufficiently recognised problem]. ( Bosch, FH; Kramers, C; Manders, M; van Luin, M, 2017) |
| "Although metformin has become a drug of choice for the treatment of type 2 diabetes mellitus, some patients may not receive it owing to the risk of lactic acidosis." | 8.93 | Metformin-associated lactic acidosis: Current perspectives on causes and risk. ( Bicsak, TA; Chen, K; DeFronzo, R; Fleming, GA, 2016) |
| "Metformin (MF) accumulation during acute kidney injury is associated with high anion gap lactic acidosis type B (MF-associated lactic acidosis, MALA), a serious medical condition leading to high mortality." | 8.93 | Metformin associated lactic acidosis (MALA): clinical profiling and management. ( Coclite, D; Manzione, A; Maresca, B; Menè, P; Moioli, A; Napoletano, AM; Pirozzi, N; Punzo, G, 2016) |
| "The aim of this study is to study the mortality rate in so-called "metformin-associated lactic acidosis" (MALA) from the 1960s to date and to establish whether the rate has changed over time." | 8.90 | Mortality rate in so-called "metformin-associated lactic acidosis": a review of the data since the 1960s. ( Kajbaf, F; Lalau, JD, 2014) |
| "Metformin is known to be rarely associated with lactic acidosis, a serious condition with a poor prognosis." | 8.89 | Metformin-associated lactic acidosis requiring hospitalization. A national 10 year survey and a systematic literature review. ( Ferrazin, F; Finco, G; Landoni, G; Mura, P; Pani, L; Renda, F, 2013) |
| "Lactic acidosis in diabetic patients undergoing metformin therapy is a widely recognized, rare but usually serious adverse event, particularly in presence of comorbidities such as cardiorespiratory disease, sepsis and renal failure." | 8.88 | Iodine-based radiographic contrast medium may precipitate metformin-associated lactic acidosis in diabetic patients. A case report, literature review and practical approach. ( Tonolini, M, 2012) |
| "Metformin Associates lactic acidosis (MALA) is a metabolic acidosis with higher anion gap, high levels of blood lactates and treatment by metformin." | 8.88 | [Metformin associates lactic acidosis]. ( Jouzel, C; Mesnard, L; Montini, F; Peltier, J; Ridel, C; Rondeau, E, 2012) |
| "To systematically review evidence about the relationship between metformin administration and the use of iodinated contrast medium and risk of lactic acidosis (LA) and to assess the quality of five current guidelines for use of contrast medium in patients who are taking metformin." | 8.86 | Systematic review of current guidelines, and their evidence base, on risk of lactic acidosis after administration of contrast medium for patients receiving metformin. ( Compton, G; Goergen, SK; Harris, C; Rumbold, G, 2010) |
| " Metformin, however, is thought to increase the risk of lactic acidosis, and has been considered to be contraindicated in many chronic hypoxemic conditions that may be associated with lactic acidosis, such as cardiovascular, renal, hepatic and pulmonary disease, and advancing age." | 8.86 | Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. ( Greyber, E; Pasternak, GA; Salpeter Posthumous, EE; Salpeter, SR, 2010) |
| " Metformin, however, is thought to increase the risk of lactic acidosis, and has been considered to be contraindicated in many chronic hypoxemic conditions that may be associated with lactic acidosis, such as cardiovascular, renal, hepatic and pulmonary disease, and advancing age." | 8.86 | Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. ( Greyber, E; Pasternak, GA; Salpeter, EE; Salpeter, SR, 2010) |
| "Lactic acidosis associated with metformin treatment is a rare but important adverse event, and unravelling the problem is critical." | 8.86 | Lactic acidosis induced by metformin: incidence, management and prevention. ( Lalau, JD, 2010) |
| "Metformin is commonly used in diabetes mellitus type 2, with lactic acidosis being a rare but potentially fatal complication of this therapy." | 8.85 | Should dialysis be offered in all cases of metformin-associated lactic acidosis? ( Finkle, SN, 2009) |
| " Search terms included metformin, heart failure, lactic acidosis, clinical trials, and insulin resistance." | 8.84 | The safety of metformin in heart failure. ( Roberts, F; Ryan, GJ, 2007) |
| "Lactic acidosis in metformin use is a widely recognised but rare side effect." | 8.84 | Reality of severe metformin-induced lactic acidosis in the absence of chronic renal impairment. ( Bosch, FH; Bruijstens, LA; Buscher-Jungerhans, PM; van Luin, M, 2008) |
| "To assess the incidence of fatal and nonfatal lactic acidosis with metformin use compared to placebo and other glucose-lowering treatments in patients with type 2 diabetes mellitus." | 8.83 | Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. ( Greyber, E; Pasternak, G; Salpeter, E; Salpeter, S, 2006) |
| " The keywords were: lactic acidosis, metformin, biguanide, diabetes mellitus." | 8.83 | [Metformin-associated lactic acidosis]. ( Chatti, O; Ghaddab, A; Ichai, C; Orban, JC, 2006) |
| "To assess the incidence of fatal and nonfatal lactic acidosis with metformin use compared to placebo and other glucose-lowering treatments in patients with type 2 diabetes mellitus." | 8.82 | Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. ( Greyber, E; Pasternak, G; Salpeter, E; Salpeter, S, 2003) |
| "Metformin therapy for type 2 diabetes mellitus has been shown to reduce total mortality rates compared with other antihyperglycemic treatments but is thought to increase the risk of lactic acidosis." | 8.82 | Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis. ( Greyber, E; Pasternak, GA; Salpeter, EE; Salpeter, SR, 2003) |
| "Metformin has been associated with the serious side-effect lactic acidosis." | 8.82 | Metformin and lactic acidosis: cause or coincidence? A review of case reports. ( Erkelens, DW; Heikens, JT; Hoekstra, JB; Holleman, F; Stades, AM, 2004) |
| "To determine whether a causal or coincidental relationship is indicated in the literature between metaformin and lactic acidosis and to recommend clinical guidelines for the withdrawal of metformin prior to surgery." | 8.82 | Metformin lactic acidosis and anaesthesia: myth or reality? ( De Kock, M; Vreven, R, 2005) |
| "The link between metformin and lactic acidosis in metformin therapy may be causal, associated or coincidental." | 8.81 | Lactic acidosis in metformin therapy: searching for a link with metformin in reports of 'metformin-associated lactic acidosis'. ( Lalau, JD; Race, JM, 2001) |
| "To assess the incidence of fatal and nonfatal lactic acidosis with metformin use compared to placebo and other glucose-lowering treatments in patients with type 2 diabetes mellitus." | 8.81 | Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. ( Greyber, E; Pasternak, G; Salpeter, E; Salpeter, S, 2002) |
| "An extensive literature search was conducted from both Medline and Ovid (1965-98) using the following keywords: 'Type 2 diabetes mellitus', 'oral hypoglycaemic drugs', 'biguanides', 'metformin-associated lactic acidosis' and 'renal impairment'." | 8.80 | Metformin-associated lactic acidosis: a rare or very rare clinical entity? ( Brain, HP; Chan, NN; Feher, MD, 1999) |
| "We present a patient with metformin associated lactic acidosis, to remind of a potentially lethal adverse reaction." | 8.80 | [Metformin associated lactic acidosis--case reports and literature review]. ( Dale, A; Fadnes, DJ; Løvås, K, 2000) |
| "Metformin-associated lactic acidosis is not necessarily due to metformin accumulation." | 8.80 | [Current role of metformin in treatment of diabetes mellitus type 2]. ( Janssen, JA, 2000) |
| "Use of the oral antidiabetic drug metformin may cause lactic acidosis, a rare but life-threatening complication, especially in patients with renal function loss." | 8.80 | [Prevention of lactic acidosis due to metformin intoxication in contrast media nephropathy]. ( de Bruin, TW; de Haan, M; Landewé-Cleuren, S; van Zwam, WH, 2000) |
| " The danger of lactic acidosis can be avoided with the use of metformin, the less toxic of biguanides, and strict respect for contraindications." | 8.77 | [Biguanides in the treatment of diabetes mellitus]. ( Saraiva, AM, 1989) |
| "Lactic acidosis is a disease in which lactic acid accumulates in the blood and causes acidosis in the patient." | 8.31 | Metformin-associated severe lactic acidosis combined with multi-organ insufficiency induced by infection with Aeromonas veronii: A case report. ( Wu, C; Xia, Y; Zhu, X, 2023) |
| "Metformin accumulation is associated with lactic acidosis and haemodynamic instability." | 8.31 | [Metformin-associated lactic acidosis]. ( Arthurson, C; Fjære, OL; Morberg, PCW; Ringdal, KG, 2023) |
| "Metformin-associated lactic acidosis is a well-known metformin treatment complication; however, the development of euglycemic diabetic ketoacidosis (euDKA) has rarely been reported." | 8.31 | Severe lactic acidosis with euglycemic diabetic ketoacidosis due to metformin overdose. ( Fujimaru, T; Hifumi, T; Ito, Y; Kadota, N; Konishi, K; Kuno, H; Nagahama, M; Nakayama, M; Otani, N; Sekiguchi, M; Taki, F; Watanabe, K, 2023) |
| "Metformin metabolism is slowed down in T2DM patients in the hypoxic environment of the plateau; the glucose-lowering effect of the plateau is similar, and the attainment rate is low, the possibility of having serious adverse effects of lactic acidosis is higher in T2DM patients on the plateau than on the control one." | 8.31 | Effects of plateau hypoxia on population pharmacokinetics and pharmacodynamics of metformin in patients with Type 2 diabetes. ( Hu, L; Li, W; Luo, L; Luo, X; Qin, N; Shen, Y; Sun, Y; Wang, R; Wang, Z, 2023) |
| "Metformin-associated lactic acidosis (MALA) is a serious condition with high mortality." | 8.31 | Surviving cardiac arrest from severe metformin-associated lactic acidosis using extracorporeal membrane oxygenation and double continuous venovenous haemodialysis. ( Akkaoui, KK; Andersen, LV; Andreasen, JB; Nørgaard, MA, 2023) |
| "Metformin-induced lactic acidosis with acute kidney injury is rare but well known." | 8.31 | Daily dose of metformin caused acute kidney injury with lactic acidosis: a case report. ( Ariga, M; Hagita, J; Kitaichi, K; Oida, Y; Soda, M; Teramachi, H, 2023) |
| "Type B lactic acidosis is a rare but serious side effect of metformin use." | 8.31 | Treatment of severe metformin-associated lactic acidosis with renal replacement therapy and tris-hydroxymethyl aminomethane: a case report. ( Abdullin, M; Braden, GL; Hodgins, S; Landry, DL; Tiru, B; Yusim, D, 2023) |
| " Metabolic acidosis in a patient with a history of metformin intake should suggest the possibility of metformin-associated lactic acidosis, which must be treated immediately, without waiting for the results of other examinations, especially in patients with sudden blindness." | 8.31 | Reversible acute blindness in suspected metformin-associated lactic acidosis: a case report. ( Huang, R; Sun, W, 2023) |
| "Metformin associated lactic acidosis may potentially occur after combination with ribocilib, an uncommon but lethal complication from the interaction of these drugs, especially in patients who had preexisting renal impairment." | 8.12 | Lactic acidosis, a potential toxicity from drug-drug interaction related to concomitant ribociclib and metformin in preexisting renal insufficiency: A case report. ( Lagampan, C; Parinyanitikul, N; Poovorawan, N, 2022) |
| "Severe and life-threatening cases of metformin-associated lactic acidosis (MALA) are treated with renal replacement therapy." | 8.12 | Achieving High Dialysis Dose via Continuous Renal Replacement Therapy in the Setting of Metformin Associated Lactic Acidosis. A Case Series. ( Apte, YV; Pollock, HHG; Reynolds, HV; Tabah, A, 2022) |
| " We herein report a case of cardiac dysfunction due to thiamine deficiency after hemodialysis in a patient with suspected biguanide-related lactic acidosis." | 8.12 | Cardiac Dysfunction Due to Thiamine Deficiency after Hemodialysis for Biguanide-related Lactic Acidosis. ( Jimura, F; Kachi, N; Tamaki, H; Tsushima, H, 2022) |
| "BACKGROUND Metformin-associated lactic acidosis (MALA) is a relatively rare adverse effect of metformin therapy." | 8.12 | Transient Complete Blindness Due to Metformin-Associated Lactic Acidosis (MALA) Reversed with Hemodialysis. ( Barusya, C; Charokopos, A; Dumic, I; Knopps, L; Rueda Prada, L; Subramanian, A; Zurob, AS, 2022) |
| "Evidence of metformin-associated lactic acidosis (MALA) in advanced chronic kidney disease (CKD) has been limited due to high mortality rate but rare incidence rate." | 8.12 | Relationship between metformin use and lactic acidosis in advanced chronic kidney disease: The REMIND-TMU study. ( Chang, TH; Chen, C; Chen, CC; Chen, CH; Hung, YJ; Ke, SS; Ko, Y; Kuo, KN; Wei, TE, 2022) |
| "Metformin-associated lactic acidosis (MALA) is a rare but life-threatening condition." | 8.12 | A patient with severe metformin-associated lactic acidosis complicated by acute coronary syndrome: a case report. ( Ahmed, A; Gudowski, C; Mammadova, N; Pliquett, RU; Shkodivskyi, P; Soukup, J, 2022) |
| "Metformin-associated lactic acidosis (MALA) is an extremely rare but life-threatening adverse effect of metformin treatment." | 8.12 | Metformin-associated Lactic Acidosis with Hypoglycemia during the COVID-19 Pandemic. ( Hazama, Y; Irie, Y; Kosugi, M; Maruo, Y; Obata, Y; Takayama, K; Yamaguchi, H; Yasuda, T, 2022) |
| "Metformin-associated lactic acidosis (MALA) is a rare event but underrecognition may lead to unfavorable outcomes in type 2 diabetes patients." | 8.12 | Metformin-associated lactic acidosis and factors associated with 30-day mortality. ( Jayanama, K; Nongnuch, A; Parapiboon, W; Phonyangnok, B; Pichitporn, W; Sumrittivanicha, J; Sungkanuparph, S; Thammavaranucupt, K; Wongluechai, L, 2022) |
| "Lactic acidosis is the most important and life-threatening side effect of metformin that is widely used in the treatment of type 2 diabetes mellitus." | 8.02 | Continuous veno-venous hemodiafiltration in metformin-associated lactic acidosis caused by a suicide attempt: A report of two cases. ( Temizkan Kırkayak, AG; Tuncali, B; Zeyneloğlu, P, 2021) |
| " Here, we present a case of a diabetic patient with acute kidney injury, metformin-associated lactic acidosis, and COVID-19." | 8.02 | Metformin-associated lactic acidosis and acute kidney injury in the era of COVID-19. ( Kalaitzidis, RG; Koukoulaki, M; Theofilis, P; Vlachopanos, G; Vordoni, A, 2021) |
| "The aim of this case report is to specify the frequency and mortality of Metformin-Associated Lactic Acidosis (MALA) in emergency medicine, as the diagnosis seems to occur more often than estimated." | 8.02 | Metformin Associated Lactic Acidosis in Clinical Practice - A Case Series. ( Kellerer, M; Schädle, P; Tschritter, O, 2021) |
| "Although hemodialysis is recommended for patients with severe metformin-associated lactic acidosis (MALA), the amount of metformin removed by hemodialysis is poorly documented." | 8.02 | A Pharmacokinetic Analysis of Hemodialysis for Metformin-Associated Lactic Acidosis. ( Biary, R; Harding, SA; Hoffman, RS; Howland, MA; Su, MK, 2021) |
| "Metformin-associated lactic acidosis (MALA) is a widely documented adverse event of metformin." | 8.02 | The usefulness of measuring the anion gap in diagnosing metformin-associated lactic acidosis: a case series. ( Agra-Montava, I; Juanes-Borrego, A; Lozano-Polo, L; Mangues-Bafalluy, MA; Puig-Campmany, M; Ruiz-Ramos, J, 2021) |
| "Compare rates of lactic acidosis (LA) among metformin-exposed and unexposed patients with type 2 diabetes mellitus and varying degrees of chronic kidney disease (CKD)." | 8.02 | Lactic acidosis incidence with metformin in patients with type 2 diabetes and chronic kidney disease: A retrospective nested case-control study. ( Alvarez, CA; Chansard, M; Halm, EA; Hennessy, S; Lingvay, I; McGuire, DK; Miller, RT; Mortensen, EM; Pugh, MJV; Vouri, SM; Yang, H; Zullo, AR, 2021) |
| "Long-term use of metformin was associated with reduced risk of pneumonia and pneumonia-related death among Chinese individuals with diabetes." | 8.02 | Long-term metformin use and risk of pneumonia and related death in type 2 diabetes: a registry-based cohort study. ( Chan, JCN; Chow, E; Kong, APS; Lau, ESH; Luk, AOY; Ma, RCW; Shi, M; So, WY; Wu, H; Yang, A, 2021) |
| "Metformin-associated lactic acidosis (MALA) is a difficult to diagnose and potentially life-threatening disease." | 7.96 | [Severe Metformin-Associated Lactic Acidosis in a 67-Year-Old Patient]. ( Keßler, M; Rattka, M; Rottbauer, W, 2020) |
| "Metformin-associated lactic acidosis is rare despite its widespread use." | 7.96 | Successful Dialysis Treatment of Metformin Associated Lactic Acidosis, Report of Two Cases. ( Berekatoglu, N; Günay, E; Kalkan, Z; Selim Ay, M; Yaman, M; Yuksel, E, 2020) |
| "To assess whether extracorporeal treatment (ECTR) improves outcome of patients with metformin-associated lactic acidosis (MALA) and to evaluate the clinical applicability of the Extracorporeal Treatments in Poisoning Workgroup (EXTRIP) criteria for starting ECTR in metformin poisoning." | 7.96 | Extracorporeal treatment of metforminassociated lactic acidosis in clinical practice: a retrospective cohort study. ( de Meijer, A; Jansman, FGA; Taxis, K; van Berlo-van de Laar, IRF; van den Elsen-Hutten, M; Vermeij, CG, 2020) |
| "To compare the risk of lactic acidosis hospitalization between patients treated with metformin versus sulfonylureas following development of reduced kidney function." | 7.96 | Hospitalization for Lactic Acidosis Among Patients With Reduced Kidney Function Treated With Metformin or Sulfonylureas. ( Chipman, J; Chu, PY; Elasy, T; Greevy, RA; Griffin, MR; Grijalva, CG; Hackstadt, AJ; Hung, AM; Roumie, CL, 2020) |
| "Use of metformin increases plasma lactate concentration and may lead to metformin-associated lactic acidosis (MALA)." | 7.96 | Mortality and renal prognosis in isolated metformin-associated lactic acidosis treated with continuous renal replacement therapy and citrate-calcium-anticoagulation. ( Järvisalo, MJ; Uusalo, P, 2020) |
| "Metformin-associated lactic acidosis (MALA) is rarely encountered, but has a high mortality rate, Conventional treatments include hemodialysis or continuous renal replacement therapy (CRRT); however, when the disease progresses to end-stage, cardiac function is significantly inhibited, circulation cannot be maintained, CRRT cannot be tolerated, V-A extracorporeal membrane oxygenation (ECMO) may be the last treatment." | 7.96 | Extracorporeal membrane oxygenation with continuous renal replacement therapy to treat metformin-associated lactic acidosis: A case report. ( Chen, T; Liu, B; Zhu, C, 2020) |
| "Metformin-associated lactic acidosis (MALA) carries a high mortality rate." | 7.96 | Metformin-associated lactic acidosis: reinforcing learning points. ( Creagh, F; Goonoo, MS; Morris, R; Raithatha, A, 2020) |
| "Background Metformin associated lactic acidosis (MALA) is a serious adverse event with a high mortality rate of 30-50%." | 7.96 | Identifying patients with metformin associated lactic acidosis in the emergency department. ( de Meijer, A; Gedik, A; Jansman, FGA; Taxis, K; van 't Riet, E; van Berlo-van de Laar, IRF, 2020) |
| "To determine the plasma metformin concentration threshold associated with lactic acidosis and analyze the outcome in metformin-treated patients with lactic acidosis hospitalized in an emergency context." | 7.96 | A Study of Associations Between Plasma Metformin Concentration, Lactic Acidosis, and Mortality in an Emergency Hospitalization Context. ( Batteux, B; Bennis, Y; Bodeau, S; De Broe, ME; Gras-Champel, V; Lalau, JD; Lemaire-Hurtel, AS; Maizel, J; Masmoudi, K, 2020) |
| "Lactic acidosis is a feared complication of metformin therapy." | 7.96 | Metformin -associated lactic acidosis. ( Bláha, V; Lášticová, M; Šmahelová, A; Víšek, J; Zima, O, 2020) |
| " We report three cases of prospectively identified laboratory confirmed metformin-associated lactic acidosis admitted to our intensive care unit." | 7.91 | Laboratory-Confirmed Metformin-Associated Lactic Acidosis ( Canavan, C; Coyle, N; Nasim, S; Nestor, C, 2019) |
| "A 70-year-old Japanese woman with type 2 diabetes mellitus presented to an emergency room with metformin-associated lactic acidosis." | 7.91 | A patient with metformin-associated lactic acidosis successfully treated with continuous renal replacement therapy: a case report. ( Ando, M; Ariyoshi, K; Kinoshita, H; Tamura, R; Yanai, M, 2019) |
| "The choice of the specific modality and treatment duration of renal replacement therapy (RRT) to adopt in metformin-associated lactic acidosis (MALA) is still debated." | 7.91 | Sustained low-efficiency dialysis for metformin-associated lactic acidosis in patients with acute kidney injury. ( Fani, F; Ferioli, E; Fiaccadori, E; Gandolfini, I; Greco, P; Locatelli, C; Maccari, C; Maggiore, U; Parenti, E; Regolisti, G, 2019) |
| "To study the incidence of lactic acidosis due to metformin in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) stage 3-5." | 7.91 | Lactic acidosis due to metformin in type 2 diabetes mellitus and chronic kidney disease stage 3-5: is it significant? ( Guddattu, V; Mareddy, AS; Nagaraju, SP; Prabhu, RA; Rangaswamy, D, 2019) |
| " The primary outcomes were: (1) hyperlactatemia, defined as a lactate concentration ≥ 2 mmol/L at any point during hospital admission and, (2) metformin associated lactic acidosis (MALA), defined as a lactate concentration ≥ 5 mmol/L and pH <7." | 7.91 | Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose. ( Hoffman, RS; Manini, AF; Taub, ES, 2019) |
| "The use of metformin in patients with type 2 diabetes mellitus has been associated with lactic acidosis." | 7.91 | Lactic acidosis associated with metformin in patients with moderate to severe chronic kidney disease: study protocol for a multicenter population-based case-control study using health databases. ( Ávila, M; Gómez-Lumbreras, A; Manríquez, M; Morros, R; Pedrós, C, 2019) |
| "Metformin is a commonly used treatment modality in type 2 diabetes mellitus with lactic acidosis as a rare but life-threatening side effect." | 7.91 | Metformin-associated lactic acidosis treated successfully by peritoneal dialysis in a resource limited setting: case report. ( Ekpebegh, C; Elmezughi, K, 2019) |
| "Metformin-associated lactic acidosis is a rare but serious complication of taking metformin." | 7.91 | Metformin-Associated Lactic Acidosis Presenting Like Acute Mesenteric Ischemia. ( Hastings, C; Johnson, K; Slaven, E; Zhang, QC, 2019) |
| "Pharmacokinetic data suggest that the risk of metformin-associated lactic acidosis (MALA) may be increased after Roux-en-Y gastric bypass (RYGB) surgery." | 7.88 | Risk of Metformin-Associated Lactic Acidosis (MALA) in Patients After Gastric Bypass Surgery. ( Aarts, EO; Aelfers, SCW; Berends, FJ; de Boer, H; Deden, LN; Janssen, IMC; van Borren, MMGJ, 2018) |
| "Metformin-associated lactic acidosis (MALA) is a rare complication among patients who are diabetic, commonly presenting with non-specific findings, and developing mostly among those with other risk factors for lactic acidosis." | 7.88 | Metformin-associated lactic acidosis mimicking ischaemic bowel. ( Ali, S; Azarov, N; Hindi, Z; Labuschagne, H; Oud, L, 2018) |
| "A new diagnostic paradigm has been proposed to better categorize causes of Metformin-Associated Lactic Acidosis (MALA)." | 7.88 | Metformin-Induced Lactic Acidosis (MILA): Review of current diagnostic paradigm. ( Al-Khalisy, H; Kaul, P; Krowl, L, 2018) |
| "Metformin associated lactic acidosis (MALA) is a well-known serious side effect of biguanides." | 7.88 | Metformin associated lactic acidosis: a case series of 28 patients treated with sustained low-efficiency dialysis (SLED) and long-term follow-up. ( Angioi, A; Atzeni, A; Cabiddu, G; Cao, R; Conti, M; Floris, M; Matta, V; Mulas, MF; Pani, A; Pili, G; Rosner, M; Songini, M, 2018) |
| "To report a case of severe lactic acidosis and hypoglycemia due to acute metformin intoxication in a dog." | 7.88 | Severe lactic acidosis and hypoglycemia due to acute metformin intoxication in a dog. ( Borchers, A; Ueda, Y; Wong, C, 2018) |
| "To estimate the incidence rate of lactic acidosis in patients with type 2 diabetes mellitus as well as to estimate the relative risk of lactic acidosis associated with metformin treatment." | 7.88 | Risk of lactic acidosis in type 2 diabetes patients using metformin: A case control study. ( Aharaz, A; Beck-Nielsen, H; Hallas, J; Henriksen, DP; Lassen, AT; Pottegård, A, 2018) |
| "Metformin toxicity is well known to cause lactic acidosis." | 7.88 | Recurrent hypoglycemia secondary to metformin toxicity in the absence of co-ingestions: a case report. ( Aldobeaban, S; Alshehri, AA; Mzahim, B, 2018) |
| "Metformin is an antidiabetic drug; used to treat type II diabetes mellitus, metformin associated lactic acidosis has an incidence of 2-9 cases / 100,000 patients / year with high mortality (30%)." | 7.88 | [A case of severe metformin-associated lactic acidosis treated with CVVHDF and regional anticoagulation with sodium citrate]. ( Apicella, A; Beretta, E; Della Morte, M; Ferrario, M, 2018) |
| " Metformin-associated lactic acidosis (MALA) is one such rare, life-threatening adverse drug effect." | 7.88 | Metformin-associated lactic acidosis precipitated by liraglutide use: adverse effects of aggressive antihyperglycaemic therapy. ( Hannallah, F; Hooda, A; Mehta, A, 2018) |
| "Metformin is renally excreted and has been associated with the development of lactic acidosis." | 7.85 | Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study. ( Connelly, PJ; Donnelly, L; Lonergan, M; Pearson, ER; Soto-Pedre, E; Zhou, K, 2017) |
| "Chronic metformin treatment mildly increases lactate level, but does not induce hyperlactatemia or lactic acidosis in acute illness on the first day of admission to an internal medicine ward." | 7.85 | Metformin Does Not Induce Hyperlactatemia in Patients Admitted to Internal Medicine Ward. ( Doenyas-Barak, K; Golik, A; Koren, R; Koren, S; Zilberman-Itskovich, S, 2017) |
| "Whether metformin precipitates lactic acidosis in patients with chronic kidney disease (CKD) remains under debate." | 7.85 | Risk of acute kidney injury and survival in patients treated with Metformin: an observational cohort study. ( Bell, S; Colhoun, HM; Farran, B; Leese, GP; Lindsay, R; Looker, H; McCrimmon, RJ; McGurnaghan, S; McKeigue, P; McKnight, J; Petrie, JR; Sattar, N; Wild, S, 2017) |
| "Metformin associated lactic acidosis (MALA) is a rare but lethal complication." | 7.85 | Metformin is not associated with lactic acidosis in patients with diabetes undergoing coronary artery bypass graft surgery: a case control study. ( Alburikan, KA; Nazer, RI, 2017) |
| "In renal failure metformin can lead to lactic acidosis." | 7.85 | Combined metformin-associated lactic acidosis and euglycemic ketoacidosis. ( Eisner, F; Eller, K; Eller, P; Lind, A; Mader, JK; Pieber, TR; Plank, J; Schilcher, G; Schwetz, V, 2017) |
| "Metformin-associated lactic acidosis is a severe and infrequent adverse event." | 7.85 | [Metformin-associated lactic acidosis. Report of one case]. ( Dreyse, J; Orozco, R; Pezzani, MJ; Quintana, F; Regueira, T; Soto, L, 2017) |
| "To assess risk of lactic acidosis among metformin users compared with other glucose-lowering agent users, according to renal function." | 7.85 | Metformin use and risk of lactic acidosis in people with diabetes with and without renal impairment: a cohort study in Denmark and the UK. ( Christiansen, CF; Ehrenstein, V; Gopalakrishnan, C; Heide-Jørgensen, U; Jick, S; Li, L; Nørrelund, H; Sørensen, HT, 2017) |
| " There was no difference in prevalence of hyperlactatemia and lactic acidosis between the patients with and without metformin use (18." | 7.85 | Association between Metformin Use and Risk of Lactic Acidosis or Elevated Lactate Concentration in Type 2 Diabetes. ( Cha, BS; Han, E; Hwang, S; Kang, ES; Kang, HP; Lee, BW; Lee, EY; Lee, HC; Lee, SH; Lee, W; Lee, YH; Lee, YM, 2017) |
| "Metformin-associated lactic acidosis (MALA) is a rare but life-threatening complication." | 7.85 | Metformin-associated lactic acidosis treated with continuous renal replacement therapy. ( Imai, H; Katayama, N; Nakamura, A; Suzuki, K, 2017) |
| "Metformin intoxication with lactic acidosis, a potentially lethal condition, may develop in diabetic patients when the drug dose is inappropriate and/or its clearance is reduced." | 7.85 | Treatment of Metformin Intoxication Complicated by Lactic Acidosis and Acute Kidney Injury: The Role of Prolonged Intermittent Hemodialysis. ( Antoniotti, R; Fani, F; Fiaccadori, E; Greco, P; Regolisti, G, 2017) |
| "Metformin-associated lactic acidosis (MALA) is a rare but life-threatening adverse drug reaction of metformin, the most frequently prescribed medication for patients with type 2 diabetes mellitus." | 7.83 | Metformin-Associated Lactic Acidosis Presenting as Acute ST-Elevation Myocardial Infarction. ( Cole, JB; Driver, BE; White, S, 2016) |
| "Metformin-associated lactic acidosis (MALA) is one of the most important drug toxicities with a high morbidity and mortality rate." | 7.83 | Myocardial injury and acute renal failure associated with lactic acidosis due to suicide attempt with metformin. ( Berber, E; Ordu, O; Ozdemir, A; Ozen, B; Sertbas, M; Sertbas, Y, 2016) |
| "The role of metformin in lactic acidosis is regularly questioned." | 7.83 | Lactic acidosis: relationship between metformin levels, lactate concentration and mortality. ( Altman, JJ; Boucaud-Maitre, D; Bouhanick, B; Doucet, J; Emmerich, J; Girardin, E; Kaloustian, E; Lassmann Vague, V; Porokhov, B; Ropers, J, 2016) |
| "To evaluate the strength of association between lactic acidosis (LA) and well-recognized risk factors for LA, particularly the weight of metformin." | 7.83 | Lactic Acidosis in Diabetic Population: Is Metformin Implicated? Results of a Matched Case-Control Study Performed on the Type 2 Diabetes Population of Grenoble Hospital University. ( Chanoine, S; Giai, J; Lepelley, M; Villier, C; Yahiaoui, N, 2016) |
| "A 72-year-old woman with a history of type 2 diabetes mellitus was brought to the ER with metformin-associated lactic acidosis." | 7.83 | A Fatal Case of Metformin-associated Lactic Acidosis. ( Fujita, Y; Hamada, T; Kawato, R; Minatoguchi, S; Murai, Y; Nomura, A; Oyama, Y; Ozeki, T; Ryuge, A; Shimizu, H; Takasugi, K; Tomino, T; Watanabe, M, 2016) |
| "In conclusion, our findings support the low risk of MALA among patients with mild-to-moderate renal impairment and the likelihood of metformin to be an innocent bystander without a pathogenic role in the lactic acidosis in most cases." | 7.83 | Retrospective analysis of lactic acidosis-related parameters upon and after metformin discontinuation in patients with diabetes and chronic kidney disease. ( Acikgoz, SB; Genc, AB; Nalbant, A; Sipahi, S; Solak, Y; Tamer, A; Yildirim, M; Yilmaz, U, 2016) |
| "We report a case of metformin-associated lactic acidosis (MALA) in the setting of normal renal function and review the relevant medical literature." | 7.83 | Metformin-Associated Lactic Acidosis in a Patient with Normal Renal Function. ( Ellen, R; Omar, A; Sorisky, A, 2016) |
| "To estimate the incidence of lactic acidosis (LA) and role of metformin in Japanese patients with type 2 diabetes mellitus (T2DM) treated with anti-diabetes drugs." | 7.83 | Epidemiology of lactic acidosis in type 2 diabetes patients with metformin in Japan. ( Chang, CH; Dolin, P; Sakaguchi, M, 2016) |
| "We report a case of metformin-associated lactic acidosis (MALA) in a 66-year-old man with end-stage renal disease on peritoneal dialysis (PD)." | 7.83 | Peritoneal dialysis treatment of metformin-associated lactic acidosis in a diabetic nephropathy patient . ( Gao, J; Gu, Z; Na, Y; Xu, Y, 2016) |
| "The principal objective of this study was to retrospectively review a series of cases of lactic acidosis (LA) in patients with type 2 diabetes mellitus (T2DM) and examine the relationship with the use of metformin." | 7.83 | Lactic acidosis and the relationship with metformin usage: Case reports. ( Castelino, RL; Huang, W; Peterson, GM, 2016) |
| "Lactic acidosis is the most severe adverse effect associated with metformin therapy of type 2 diabetes mellitus." | 7.83 | [Lactic acidosis due to metformin accumulation complicating acute gastroenteritis]. ( DŽupová, O; Kulichová, J, 2016) |
| "The March 2012 regulatory action issued by the Japanese government signalled the rare but serious complication of lactic acidosis that can occur during metformin treatment, especially with the high dose formulation, h-metformin, and in those above 75 years old." | 7.81 | Impact of Japanese regulatory action on metformin-associated lactic acidosis in type II diabetes patients. ( Hanatani, T; Sai, K; Saito, Y; Segawa, K; Tohkin, M, 2015) |
| "Metformin-induced lactic acidosis is a rare but severe disease for the individual patients." | 7.81 | [Metformin-induced lactic acidosis : Severe symptoms with difficult diagnostics]. ( Brenner, T; Decker, SO; Hofer, S; Siegler, BH; Ulrich, A; Wortmann, M, 2015) |
| " All cases of lactic acidosis (pH, ≤ 7." | 7.80 | Metformin accumulation: lactic acidosis and high plasmatic metformin levels in a retrospective case series of 66 patients on chronic therapy. ( Giampreti, A; Locatelli, CA; Lonati, D; Manzo, L; Papa, P; Petrolini, VM; Protti, A; Rocchi, L; Rognoni, C; Rolandi, L; Valli, A; Vecchio, S, 2014) |
| "The objective of this study was to determine whether treatment with metformin in patients with renal impairment is associated with a higher risk of lactic acidosis or elevated lactate concentrations compared with users of a noninsulin antidiabetic drug (NIAD) who had never used metformin." | 7.80 | Risk of lactic acidosis or elevated lactate concentrations in metformin users with renal impairment: a population-based cohort study. ( De Smet, PA; de Vries, F; Derijks, HJ; Egberts, A; Eppenga, WL; Geerts, AF; Lalmohamed, A; Wensing, M, 2014) |
| "Two patients with type 2 DM developed acute kidney injury and lactic acidosis following colonoscopy despite withholding metformin." | 7.80 | Acute renal failure and metformin-associated lactic acidosis following colonoscopy. ( Connor, SJ; Depczynski, B; Hall, BM; Hussain, MI, 2014) |
| "To determine whether the use of metformin in type 2 diabetic patients with various kidney functions is associated with an increased risk of lactic acidosis (LA)." | 7.80 | Incidence of lactic acidosis in patients with type 2 diabetes with and without renal impairment treated with metformin: a retrospective cohort study. ( Corvino, FA; Gottwald-Hostalek, U; Guedes, S; Richy, FF; Sabidó-Espin, M, 2014) |
| "Metformin-associated lactic acidosis is a diagnosis by exclusion; however, a high degree of clinical suspicion supplemented by prompt multisystem organ support can significantly influence the outcome in critically ill patients." | 7.80 | Metformin-associated lactic acidosis presenting as an ischemic gut in a patient who then survived a cardiac arrest: a case report. ( Ncomanzi, D; Sicat, RM; Sundararajan, K, 2014) |
| "There is controversy surrounding the risk of metformin and the development of lactic acidosis." | 7.80 | Pharmacist review prevents evolving metformin-associated lactic acidosis. ( Kyle, G; Naunton, M; Naunton-Boom, K; Owoka, F, 2014) |
| "Lactic acidosis is a well-known complication of the anti-hyperglycemic biguanide agent metformin, especially in peculiar but not rare clinical conditions." | 7.80 | Metformin-associated lactic acidosis and temporary ileostomy: a case report. ( Margiani, C; Mura, P; Restivo, A; Saba, M; Scintu, F; Zorcolo, L, 2014) |
| " There was concomitant ACE inhibitor (ACEi) use and metformin toxicity with severe lactic acidosis." | 7.79 | Feeling blue with metformin-associated lactic acidosis. ( Parker, A; Plumb, B; Wong, P, 2013) |
| "Lactic acidosis is a well-recognized consequence of metformin." | 7.79 | Metformin overdose-induced hypoglycemia in the absence of other antidiabetic drugs. ( Al-Abri, SA; Hayashi, S; Olson, KR; Thoren, KL, 2013) |
| "Lactic acidosis is an adverse event associated with metformin usage." | 7.79 | The Role of Metformin in Metformin-Associated Lactic Acidosis (MALA): Case Series and Formulation of a Model of Pathogenesis. ( Day, RO; Duong, JK; Furlong, TJ; Graham, GG; Greenfield, JR; Roberts, DM; Williams, KM, 2013) |
| "Analysis of the prognostic values of blood pH and lactate and plasma metformin concentrations in severe metformin-associated lactic acidosis may help to resolve the following paradox: metformin provides impressive, beneficial effects but is also associated with life-threatening adverse effects." | 7.79 | The prognostic value of blood pH and lactate and metformin concentrations in severe metformin-associated lactic acidosis. ( Kajbaf, F; Lalau, JD, 2013) |
| "Lactic acidosis is a rare but severe complication in patients with type 2 diabetes treated with metformin." | 7.79 | Metformin-induced lactic acidosis associated with multiorganic failure. ( Bajrami, V; Barbullushi, M; Bolleku, E; Idrizi, A; Likaj, E; Nunci, L; Ohri, I; Thereska, N, 2013) |
| "To study the quality of pharmacovigilance reporting in cases of so-called 'metformin-associated lactic acidosis' and, ultimately, whether or not the criteria for this condition are indeed met." | 7.79 | The criteria for metformin-associated lactic acidosis: the quality of reporting in a large pharmacovigilance database. ( Kajbaf, F; Lalau, JD, 2013) |
| "Metformin associated lactic acidosis (MALA) is a serious complication occurring especially in elderly patients given high doses of the drug." | 7.79 | Monitoring of metformin-induced lactic acidosis in a diabetic patient with acute kidney failure and effect of hemodialysis. ( Amiel, JB; Laforest, C; Merle, L; Pichon, N; Saint-Marcoux, F, 2013) |
| "The existence of metformin-induced lactic acidosis has been questioned, in particular in the absence of specific risk factors such as impaired renal function." | 7.78 | Metformin-associated lactic acidosis in a patient with normal kidney function. ( Brouwers, MC; Pijpers, E; Stehouwer, CD; van Sloten, TT, 2012) |
| " Metformin-associated lactic acidosis may sometimes be life-threatening." | 7.78 | Metformin-associated lactic acidosis following acute kidney injury. Efficacious treatment with continuous renal replacement therapy. ( Dahan, E; Dichtwald, S; Ekstein, MP; Sorkine, P; Weinbroum, AA, 2012) |
| "Lactic acidosis is a fatal adverse effect of metformin, but the risk factor remains unclear." | 7.78 | Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis. ( Fujimoto, S; Hosokawa, M; Inagaki, N; Inui, K; Katsura, T; Masuda, S; Osawa, R; Toyama, K; Yonezawa, A, 2012) |
| "Hepatic mitochondrial dysfunction may play a critical role in the pathogenesis of metformin-induced lactic acidosis." | 7.78 | Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs. ( Comi, GP; De Giuseppe, R; Fortunato, F; Gatti, S; Gattinoni, L; Monti, M; Protti, A; Vecchio, S, 2012) |
| " He was diagnosed with metformin-associated lactic acidosis and acute kidney injury." | 7.78 | Toxicokinetics of metformin-associated lactic acidosis with continuous renal replacement therapy. ( Agarwala, R; Anderson, H; Cheng, JT; Geara, AS; Madhrira, M; Mohan, S; Mujtaba, M, 2012) |
| " We present a case of a 65-year-old Caucasian man who presented with metformin associated lactic acidosis." | 7.78 | Survival after cardiopulmonary arrest with extreme hyperkalaemia and hypothermia in a patient with metformin-associated lactic acidosis. ( Lee, IL; Tay, S, 2012) |
| "To evaluate the significance of diabetes mellitus and metformin in patients admitted to medical ICU with lactic acidosis." | 7.78 | Lactic acidosis in medical ICU - the role of diabetes mellitus and metformin. ( Charvat, J; Havlin, J; Hloch, O; Masopust, J, 2012) |
| "We describe two cases of severe metformin-related lactic acidosis with underlying acute kidney injury, which were treated with dialysis." | 7.77 | Metformin-related lactic acidosis in patients with acute kidney injury. ( Devetzis, V; Georgoulidou, A; Panagoutsos, S; Passadakis, P; Theodoridis, M; Thodis, E; Vargemezis, V, 2011) |
| "Metformin has long been thought to cause lactic acidosis (LA) but evidence from various sources has led researchers to question a direct causative relationship." | 7.77 | Diabetes, metformin and lactic acidosis. ( Harvey, JN; Scale, T, 2011) |
| "We present an uncommon case of lactic acidosis after concomitant administration of Metformin and Tenofovir." | 7.77 | Lactic acidosis after concomitant treatment with metformin and tenofovir in a patient with HIV infection. ( Alivanis, P; Aperis, G; Arvanitis, A; Paliouras, C; Zervos, A, 2011) |
| " Two cases of lactic acidosis due to ingestion of high dose metformin for suicidal purposes have been presented here; in both cases, clinical improvement was seen with bicarbonate hemodialysis." | 7.77 | Dialysis therapy for lactic acidosis caused by metformin intoxication: presentation of two cases. ( Aytemiz, E; Begenik, H; Emre, H; Erkoc, R; Ozturk, M; Soyoral, YU, 2011) |
| "The reported incidence of metformin associated lactic acidosis (MALA) in type 2 diabetes mellitus (DM) is 3-9 cases per 100,000 patient-years." | 7.77 | Metformin associated lactic acidosis: incidence and clinical correlation with metformin serum concentration measurements. ( Doorenbos, CJ; van Berlo-van de Laar, IR; Vermeij, CG, 2011) |
| "Metformin-associated lactic acidosis (MALA) is a severe metabolic failure with high related mortality." | 7.77 | Management of metformin-associated lactic acidosis by continuous renal replacement therapy. ( Argaud, L; Cour, M; Hernu, R; Illinger, J; Keller, G; Robert, D, 2011) |
| "Lactic acidosis has been considered to be a side effect of some biguanides, after phenformin was withdrawn from the market because of its association with lactic acidosis." | 7.76 | Comparison of potential risks of lactic acidosis induction by biguanides in rats. ( Bando, K; Deguchi, J; Funabashi, H; Kimura, J; Kunimatsu, T; Ochiai, S; Seki, T, 2010) |
| "Metformin-associated lactic acidosis (MALA) is well described in patients taking therapeutic metformin who develop renal failure or other serious comorbid conditions." | 7.76 | Can acute overdose of metformin lead to lactic acidosis? ( Bryant, SM; Buckley, P; Seo, B; Wills, BK, 2010) |
| "Metformin associated lactic acidosis (MALA) is a rare condition with a prevalence of 3 per 100,000 patient-years." | 7.76 | [Metformin treatment causes persisting lactic acidosis after cardiac arrest]. ( Gamst, J; Hansen, LK; Rasmussen, BS, 2010) |
| "Metformin associated lactic acidosis (MALA) may complicate metformin therapy, particularly if metformin accumulates due to renal dysfunction." | 7.76 | Outcome of severe lactic acidosis associated with metformin accumulation. ( Abel, P; Felix, SB; Friesecke, S; Roser, M; Runge, S, 2010) |
| "Metformin, a widely used hypoglycaemic agent in type 2 diabetes mellitus, is uncommonly associated with lactic acidosis, a serious condition with high mortality." | 7.76 | Metformin-associated lactic acidosis (MALA): clinical profile and outcomes in patients admitted to the intensive care unit. ( Biradar, V; Moran, JL; Peake, SL; Peter, JV, 2010) |
| "From January 2004 to November 2008, 11 cases of metformin-associated lactic acidosis were seen at a medical center in Taiwan." | 7.75 | Impact of acute kidney injury on metformin-associated lactic acidosis. ( Wen, YK, 2009) |
| "Metformin-associated lactic acidosis is a very rare but critical condition." | 7.75 | Successful treatment of severe lactic acidosis caused by a suicide attempt with a metformin overdose. ( Lin, HD; Lin, KH; Lo, SH; Wang, LM; Yang, PW, 2009) |
| "Metformin-associated lactic acidosis is a rare and serious complication of biguanide treatment." | 7.75 | Metformin-associated lactic acidosis: a prognostic and therapeutic study. ( Fourrier, F; Houdret, N; Nseir, S; Seidowsky, A, 2009) |
| "A 74-year-old man with cardiac failure and renal impairment was admitted to the cardiothoracic intensive care unit with metformin-induced lactic acidosis and shock." | 7.75 | Continuous venovenous haemodiafiltration for metformin-induced lactic acidosis. ( MacLaren, G; Pan, LT, 2009) |
| " The effect of GFJ on glucose tolerance and metformin-induced lactic acidosis in normal, non-diabetic in rats is hereby investigated." | 7.75 | Grapefruit juice improves glycemic control but exacerbates metformin-induced lactic acidosis in non-diabetic rats. ( Ojewole, JA; Owira, PM, 2009) |
| "The case history is presented of a patient who developed metformin-associated lactic acidosis." | 7.74 | Heeding clues to metformin-associated lactic acidosis: prompt response can save life. ( Chennavir, B; Gopi, A; Kumar, U, 2008) |
| "Lactic acidosis has been associated with use of metformin." | 7.74 | Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis. ( Bodmer, M; Jick, SS; Krähenbühl, S; Meier, C; Meier, CR, 2008) |
| "Metformin-associated lactic acidosis (MALA) is a classic side effect of metformin and is known to be a severe disease with a high mortality rate." | 7.74 | Metformin-associated lactic acidosis in an intensive care unit. ( Barraud, D; Bollaert, PE; Cravoisy, A; Gibot, S; Jay, N; Nace, L; Peters, N, 2008) |
| "We report the case of a 46-yr-old male who developed severe lactic acidosis, cardiorespiratory arrest, and rhabdomyolysis following an overdose of metformin and ramipril." | 7.74 | Severe lactic acidosis and rhabdomyolysis following metformin and ramipril overdose. ( Bramham, K; Galea, M; Jelacin, N; White, I, 2007) |
| "A French analysis of reports of adverse effects shows that lactic acidosis due to metformin is preventable." | 7.74 | Metformin: preventable lactic acidosis. ( , 2007) |
| "We suspect that the life-threatening complication of metformin-associated lactic acidosis, solely due to drug accumulation following renal impairment, occurs more frequently than that previously reported and is not necessarily associated with other predisposing factors for lactic acidosis." | 7.74 | Metformin-associated lactic acidosis in patients with renal impairment solely due to drug accumulation? ( Felix, SB; Friesecke, S; Mayerle, J; Robinson, D; Roser, M; Runge, S; Warnke, C, 2008) |
| "Risk determinants for the life threatening complication of metformin-associated lactic acidosis are frequently disregarded." | 7.74 | Prevalence of risk determinants for metformin-associated lactic acidosis and metformin utilization in the study of health in pomerania. ( Alte, D; Baumeister, SE; Runge, S; Völzke, H, 2008) |
| "To determine the incidence of lactic acidosis in community-based patients with type 2 diabetes, with special reference to metformin therapy." | 7.74 | Metformin and lactic acidosis in an Australian community setting: the Fremantle Diabetes Study. ( Bruce, DG; Davis, TM; Davis, WA; Kamber, N, 2008) |
| "Metformin-associated lactic acidosis is a rare but serious condition and potentially even more hazardous during pregnancy." | 7.74 | Metformin-associated lactic acidosis in a pregnant patient. ( Chen, IC; Hong, YC; Hsiao, CT; Kuan, JT; O'Boyle, CP, 2008) |
| "In this report of a near-fatal metformin ingestion successfully treated with alkalinization and high-volume hemofiltration, we discuss the management of severe lactic acidosis and demonstrate that early aggressive intervention resulted in a positive outcome." | 7.73 | Severe lactic acidosis complicating metformin overdose successfully treated with high-volume venovenous hemofiltration and aggressive alkalinization. ( Harvey, B; Hickman, C; Hinson, G; Mayer, A; Ralph, T, 2005) |
| "Lactic acidosis is a known adverse risk of metformin treatment." | 7.73 | Fulminant lactic acidosis in two patients with Type 2 diabetes treated with metformin. ( Brassøe, R; Elkmann, T; Gravholt, CH; Hempel, M, 2005) |
| "Metformin-associated lactic acidosis (MALA) is a rare but serious clinical entity." | 7.73 | Metformin-associated lactic acidosis precipitated by acute renal failure. ( Shenoy, C, 2006) |
| "Lactic acidosis is an infrequent complication of metformin therapy for diabetes mellitus." | 7.73 | Metformin-associated lactic acidosis treated with continuous renal replacement therapy. ( Alivanis, P; Arvanitis, A; Giannikouris, I; Paliuras, C; Volanaki, M; Zervos, A, 2006) |
| "Biguanides are a class of drugs widely used as oral antihyperglycemic agents for the treatment of type 2 diabetes mellitus, but they are associated with lactic acidosis, a lethal side effect." | 7.72 | Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. ( Jonker, JW; Kato, Y; Kusuhara, H; Schinkel, AH; Sugiyama, Y; Wang, DS, 2003) |
| "In type II diabetes treated with metformin, lactic acidosis is a rare but severe complication." | 7.72 | [Metformin-associated lactic acidosis precipitated by acute renal failure]. ( Azoulay, E; Galy-Floc'h, M; Mariot, J; Pertek, JP; Vidal, S, 2003) |
| "We report 4 cases of lactic acidosis in diabetic patients usually treated with metformin." | 7.72 | [Metformin-associated lactic acidosis remains a serious complication of metformin therapy]. ( Giunti, C; Grimaud, D; Ichai, C; Levraut, J; Orban, JC, 2003) |
| "A patient with acute renal failure associated with lactic acidosis as a result of concurrent treatment with metformin is described." | 7.72 | Metformin lactic acidosis, acute renal failure and rofecoxib. ( Price, G, 2003) |
| "Lactic acidosis is a recognised complication of the antihyperglycaemic biguanide agent metformin, especially in patients with renal failure." | 7.72 | Unexpected survival from severe metformin-associated lactic acidosis. ( de Gooijer, A; Schure, PJ; van Zanten, AR, 2003) |
| "Metformin is widely used in the treatment of type 2 diabetes, though it is recognized to be associated with the risk of lactic acidosis." | 7.72 | Experiences of a poison center with metformin-associated lactic acidosis. ( Sacha Weilemann, L; Sauer, O; von Mach, MA, 2004) |
| "Metformin is commonly prescribed to treat type 2 diabetes mellitus, however it is associated with the potentially lethal condition of lactic acidosis." | 7.72 | Do risk factors for lactic acidosis influence dosing of metformin? ( Cottrell, N; Green, B; Millican, S, 2004) |
| "Metformin Associated Lactic Acidosis (MALA) is a rare, but serious complications of Type 2 diabetes mellitus treatment with a mortality rate of around 50%." | 7.71 | An unusual case of metformin associated lactic acidosis. ( Poulose, V, 2002) |
| "A case of metformin-associated lactic acidosis after elective spinal surgery is reported." | 7.71 | Metformin-associated lactic acidosis after elective cervical spine fusion: a case report. ( Brager, MD; Lipsett, PA; Mears, SC; Riley, LH, 2002) |
| "A rare side effect from metformin is lactic acidosis." | 7.71 | [Metformin and contrast media--increased risk of lactic acidosis?]. ( Draganov, B; Kløw, NE; Os, I, 2001) |
| "The risk of lactic acidosis during metformin therapy is linked to specific and well-documented conditions that constitute contraindications or precautions to use of the agent." | 7.71 | Evaluation of prescribing practices: risk of lactic acidosis with metformin therapy. ( Calabrese, AT; Coley, KC; DaPos, SV; Rao, RH; Swanson, D, 2002) |
| "Metformin-induced lactic acidosis is a common side effect in patients with renal insufficiency." | 7.71 | [Metformin-associated lactic acidosis with acute renal failure in type 2 diabetes mellitus]. ( Berner, B; Hagenlocher, S; Hummel, KM; Kleine, P; Müller, GA; Ramadori, G; Ritzel, U; Strutz, F, 2002) |
| "The antidiabetic drug metformin has been associated in a small number of patients with lactic acidosis, a serious condition with a poor prognosis." | 7.70 | Lactic acidosis in metformin-treated patients. Prognostic value of arterial lactate levels and plasma metformin concentrations. ( Lalau, JD; Race, JM, 1999) |
| "The purpose of this study was to establish guidelines on how to avoid metformin-induced lactic acidosis following intravascular use of contrast media." | 7.70 | Contrast media and metformin: guidelines to diminish the risk of lactic acidosis in non-insulin-dependent diabetics after administration of contrast media. ESUR Contrast Media Safety Committee. ( Morcos, SK; Thomsen, HS, 1999) |
| "The purpose of this study was to determine the incidence of lactic acidosis in a geographically defined population of metformin users." | 7.70 | Incidence of lactic acidosis in metformin users. ( Butler-Jones, D; Stang, M; Wysowski, DK, 1999) |
| "The biguanide drugs metformin and phenformin have been linked in the past to lactic acidosis, a metabolic condition associated with high rates of mortality." | 7.70 | Lactic acidosis in metformin therapy. ( Lalau, JD; Race, JM, 1999) |
| " This was due to a severe lactic acidosis caused by acute alcohol intoxication and the use of metformin." | 7.70 | [Severe lactic acidosis due to metformin therapy in a patient with contra-indications for metformin]. ( Holman, ND; Houwerzijl, EJ; Snoek, WJ; van Haastert, M, 2000) |
| "To investigate the role of metformin accumulation in the pathophysiology of metformin-associated lactic acidosis." | 7.69 | Role of metformin accumulation in metformin-associated lactic acidosis. ( Bleichner, G; Chauveau, P; Compagnon, P; de Cagny, B; Dulbecco, P; Guérin, C; Haegy, JM; Lacroix, C; Lalau, JD; Rigaud, JP, 1995) |
| "To determine the respective role of metformin accumulation and tissue hypoxia in triggering metformin-associated lactic acidosis (MALA), we measured plasma (PM) and red blood cell (RM) metformin concentrations in 14 patients with MALA and in 58 diabetic patients on well-tolerated chronic metformin treatment." | 7.69 | Metformin-associated lactic acidosis in diabetic patients with acute renal failure. A critical analysis of its pathogenesis and prognosis. ( De Cagny, B; Fournier, A; Lacroix, C; Lalau, JD, 1994) |
| "A 69-year-old diabetic woman with diffuse atherosclerosis presented with acute renal failure due to contrast nephropathy and severe metformin-induced lactic acidosis." | 7.69 | Metformin-induced lactic acidosis associated with acute renal failure. ( Ben-Yehuda, A; Dranitzki-Elhalel, M; Popovtzer, M; Safadi, R, 1996) |
| "Lactic acidosis associated with diabetic patients receiving metformin therapy is rare but may cause significant morbidity and mortality." | 7.68 | Metformin-induced lactic acidosis: report of a case. ( Huang, CC; Lim, PS; Wei, JS, 1992) |
| "Lactic acidosis is an extremely rare but serious complication of treatment with metformin." | 7.68 | [Lactic acidosis associated with metformin]. ( Lebech, M; Olesen, LL, 1990) |
| "Lactic acidosis in diabetics on metformin therapy is rare but still associated with poor prognosis." | 7.67 | Bicarbonate haemodialysis: an adequate treatment for lactic acidosis in diabetics treated by metformin. ( Coevoet, B; Debussche, X; Dkissi, H; Fournier, A; Lalau, JD; Quichaud, J; Temperville, B; Tolani, M; Westeel, PF, 1987) |
| "A 55 year old diabetic women treated with chlorpropamide and metformin for three years presented with acute oliguric renal failure and lactic acidosis from which she died." | 7.67 | Lactic acidosis due to metformin therapy in a low risk patient. ( Leatherdale, BA; Tymms, DJ, 1988) |
| "Metformin is an oral antihyperglycemic drug widely used to treat type 2 diabetes mellitus (T2DM), acting via indirect activation of 5' Adenosine monophosphate-activated Protein Kinase (AMPK)." | 6.72 | Mechanism and application of metformin in kidney diseases: An update. ( Meng, X; Song, A; Zhang, C, 2021) |
| "Metformin, the first choice drug for type 2 diabetes treatment in all stages of therapy, and one of the most widely prescribed anti-hyperglycemic agents worldwide, represents a rare example of an old drug which continues to display new beneficial effects in various fields." | 6.61 | Metformin lactic acidosis: Should we still be afraid? ( Adinolfi, LE; Imbriani, S; Marfella, R; Monaco, L; Nevola, R; Pafundi, PC; Ricozzi, C; Rinaldi, L; Salvatore, T; Sardu, C; Sasso, FC, 2019) |
| "Lactic acidosis is a rare, serious adverse effect of metformin, which can be prevented by carefully observing the contra-indications." | 6.41 | [Metformin efficacious in poorly controlled diabetes mellitus type 2]. ( Hoekstra, JB; Holleman, F; Stades, AM, 2000) |
| "A 40-year-old man with sensorineural hearing loss and diabetes mellitus was hospitalized with acute-onset impaired consciousness and clumsiness in his left hand." | 5.91 | Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes diagnosed after metformin-triggered stroke-like episodes. ( Ishiguchi, H; Ito, H; Murakami, K; Sakamoto, K, 2023) |
| "Despite paucity of data, it is common practice to discontinue metformin before invasive coronary angiography due to an alleged risk of Metformin-Associated Lactic Acidosis (M-ALA)." | 5.69 | Safety of metformin continuation in diabetic patients undergoing invasive coronary angiography: the NO-STOP single arm trial. ( Avvedimento, M; Chiarito, M; Condello, F; Condorelli, G; Diez Gil, JL; Federici, M; Ferrante, G; Garcia-Garcia, HM; Liccardo, G; Maurina, M; Mehran, R; Pagnotta, P; Piccolo, R; Regazzoli, D; Reimers, B; Sanz-Sanchez, J; Stefanini, G, 2023) |
| "Abnormal glucose metabolism in cancer cells causes generation and secretion of excess lactate, which results in acidification of the extracellular microenvironment." | 5.62 | Metformin induced lactic acidosis impaired response of cancer cells towards paclitaxel and doxorubicin: Role of monocarboxylate transporter. ( Bhat, MK; Chaube, B; Deb, A; Malvi, P; Mayengbam, SS; Mohammad, N; Singh, A; Singh, SV, 2021) |
| "A 58-year-old female with known type 2 diabetes mellitus continued to take her usual medications, including metformin, an ACE inhibitor and a non-steroidal anti-inflammatory drug, while suffering from diarrhoea and vomiting." | 5.62 | Metformin-associated lactic acidosis. ( Fadden, EJ; Longley, C; Mahambrey, T, 2021) |
| "Metformin overdose has been known as a risk of lactic acidosis, and previous reports have demonstrated that continuous renal replacement therapy(CRRT) is effective." | 5.56 | [Lactic Acidosis after Cardiac Surgery Treated by Continuous Renal Replacement Therapy in a Patient on Metformin;Report of a Case]. ( Matsumura, N; Nitta, Y; Saito, M; Yoshida, S, 2020) |
| "Metformin is commonly used for the treatment of type 2 diabetes mellitus." | 5.51 | Reversible Acute Blindness in Suspected Metformin-Associated Lactic Acidosis. ( Ham, YR; Jeong, WJ; Oh, SK; Ryu, S; Son, SH; You, YH, 2019) |
| " To describe a concentration range in clinical samples after chronic use of metformin, metformin serum concentrations were determined in serum samples of 95 diabetic patients receiving daily doses of 500mg-3000mg of metformin." | 5.48 | Range of therapeutic metformin concentrations in clinical blood samples and comparison to a forensic case with death due to lactic acidosis. ( Hess, C; Madea, B; Stratmann, B; Tschoepe, D; Unger, M, 2018) |
| "Metformin is a common and generally well-tolerated medication in the treatment of diabetes but rarely has been implicated as the cause for metformin-associated lactate acidosis." | 5.48 | Hemodialysis in metformin-associated lactic acidosis due to acute overdose in a metformin-naïve patient. ( Baker, S; McCabe, DJ; Stellpflug, SJ, 2018) |
| "Metformin is a first-line oral antidiabetic therapy for patients with type 2 diabetes mellitus." | 5.46 | Hemodialysis-refractory metformin-associated lactate acidosis with hypoglycemia, hypothermia, and bradycardia in a diabetic patient with belated diagnosis and chronic kidney disease . ( Zibar, K; Zibar, L, 2017) |
| "Metformin users were similar to nonusers with respect to levels of lactate, HCO3, and blood pH; however, they were older and had higher incidence rates of cardiovascular disease and acute kidney injury at admission, compared to nonusers." | 5.43 | Lactic acidosis and severe septic shock in metformin users: a cohort study. ( Beberashvili, I; Doenyas-Barak, K; Efrati, S; Marcus, R, 2016) |
| "Metformin is a basic drug used for the treatment of type 2 diabetes mellitus." | 5.43 | [Chronic kidney diseases, metformin and lactic acidosis]. ( Borbély, Z, 2016) |
| "Metformin treatment inhibited both EMT markers and Oxphos and, when its concentration raised to 10 mM, it induced a striking inhibition of proliferation and colony formation of acidic melanoma cells, both grown in protons enriched medium or lactic acidosis." | 5.43 | Metformin is also effective on lactic acidosis-exposed melanoma cells switched to oxidative phosphorylation. ( Bianchini, F; Calorini, L; Del Rosso, M; Giannoni, E; Margheri, F; Peppicelli, S; Toti, A, 2016) |
| "Metformin-treated patients may experience severe hyperlactatemia or lactic acidosis (LA)." | 5.41 | Metformin's Role in Hyperlactatemia and Lactic Acidosis in ICU Patients: A Systematic Review. ( Fuster, DG; Moser, M; Mueller, L; Prazak, J; Schefold, JC; Zuercher, P, 2023) |
| "Metformin-associated lactic acidosis is a well-described and commonly encountered condition associated with significant morbidity and mortality." | 5.41 | Expanding the evidence for managing metformin poisoning to support decision-making. ( Ghannoum, M; Roberts, DM, 2023) |
| "Lactic acidosis is a potential adverse event related to metformin therapy." | 5.41 | [Acute Renal Failure, Lactic Acidosis, and Metformin: Two Case Reports and Literature Review]. ( Cesaro, A; Del Piano, C; Del Piano, D; Diglio, A; Faggian, A; Faggian, G; Faggian, R; Salzano, M; Vitagliano, A, 2023) |
| " Metformin toxicity is a spectrum of conditions that may be differentiated into three subgroups: metformin-associated lactic acidosis (MALA), metformin-induced lactic acidosis (MILA), and metformin-unrelated lactic acidosis (MULA)." | 5.41 | High risk and low prevalence diseases: Metformin toxicities. ( Cao, JD; Koyfman, A; Long, B; Onisko, N; Rivera, D, 2023) |
| "Metformin is a biguanide group oral antidiabetic drug used for the treatment of type 2 diabetes mellitus." | 5.40 | Lactic acidosis induced by metformin in a chronic hemodialysis patient with diabetes mellitus type 2. ( Altun, E; Karayaylalı, I; Kaya, B; Paydaş, S; Sarıakçalı, B, 2014) |
| "An 82-year-old woman with type 2 diabetes mellitus, hypertension, and unstable angina presented with severe lactic acidosis and acute kidney injury (AKI) accompanied by acute pancreatitis." | 5.39 | Severe lactic acidosis and acute pancreatitis associated with cimetidine in a patient with type 2 diabetes mellitus taking metformin. ( Ahn, KS; Hong, CW; Kang, GW; Lee, DY; Lee, IH; Seo, JH, 2013) |
| "Metformin is a drug widely used in type 2 diabetic patients." | 5.38 | The importance of early haemodiafiltration in the treatment of lactic acidosis associated with the administration of metformin. ( Baró-Serra, A; Guasch-Aragay, B; Martín-Alemany, N; Sirvent, JM; Vallès-Prats, M, 2012) |
| "A metformin level was 150 μg/mL (therapeutic 1-2 μg/mL)." | 5.37 | Occult metformin toxicity in three patients with profound lactic acidosis. ( Gaieski, D; Perrone, J; Phillips, C, 2011) |
| "Metformin is a safe drug when correctly used in properly selected patients." | 5.37 | Metformin-induced lactic acidosis: no one left behind. ( Protti, A; Vecchio, S, 2011) |
| "Metformin is an antihyperglycemic agent commonly used in diabetic patients." | 5.37 | The nephrologist's role in metformin-induced lactic acidosis. ( Basterrechea, MA; de Arriba, G; Gómez-Navarro, L; Hernández-Sevillano, B; Pérez del Valle, KM; Rodríguez-Palomares, JR; Sánchez-Heras, M; Tallón, S; Torres-Guinea, M, 2011) |
| "Metformin is a widely used antidiabetic agent that is generally considered safe." | 5.37 | Metformin-associated lactic acidosis in Chinese patients with type II diabetes. ( Chan, WM; Chung, HY; Fong, BM; Siu, TS; Tam, S; Tsai, NW; Tsui, SH; Yeung, CW, 2011) |
| "Lactic acidosis is a rare side effect of metformin." | 5.34 | [Metformin-related lactic acidosis in an 85-year-old woman]. ( Jansen, PA; Knol, W; van der Linden, CM; van Marum, RJ, 2007) |
| "Metformin, however, has the potential to increase serumlactate." | 5.33 | [Metformin-associated lactic acidosis in a patient with pre-existing risk factors]. ( Becker, C; Luginbühl, A; Pittl, U; Schlienger, R, 2005) |
| "Metformin is a biguanide commonly used in type 2 diabetes and considered to be a safe drug with minimal side effects." | 5.32 | Metformin induced acute pancreatitis precipitated by renal failure. ( Mallick, S, 2004) |
| "Metformin is an oral hypoglycemic agent belonging to the class of biguanides that are commonly used in the treatment of type II diabetes mellitus." | 5.31 | Metformin-associated lactic acidosis in a low risk patient. ( Ellis, AK; Iliescu, EA, 2001) |
| " Moreover, MET-associated lactic acidosis (MALA) needs to be considered and the incidence of MALA in patients with type 2 DM-TB coinfection remains unknown." | 5.27 | A case risk study of lactic acidosis risk by metformin use in type 2 diabetes mellitus tuberculosis coinfection patients. ( Mertaniasih, NM; Novita, BD; Pranoto, A; Soediono, EI, 2018) |
| "Metformin-associated lactic acidosis (MALA) is a severe complication of drug administration with significant morbidity and mortality." | 5.24 | Metformin-Associated Lactic Acidosis Undergoing Renal Replacement Therapy in Intensive Care Units: A Five-Million Population-Based Study in the North-West of Italy. ( Amore, A; Berto, M; Berutti, S; Boero, R; Calabrese, G; Campo, A; Cantaluppi, V; Carpani, P; Comune, L; Consiglio, V; David, P; Filiberti, O; Gherzi, M; Guarena, C; Inguaggiato, P; Manes, M; Marciello, A; Mariano, F; Marino, A; Martina, G; Pozzato, M; Roscini, E; Serra, A; Stramignoni, E; Todini, V; Turello, E; Vio, P, 2017) |
| "Metformin, a molecule belonging to the biguanide family, represents one of the most commonly prescribed medications for the treatment of diabetes mellitus in the world." | 5.22 | Metformin: When Should We Fear Lactic Acidosis? ( Di Mauro, S; Filippello, A; Malaguarnera, R; Piro, S; Purrello, F; Scamporrino, A, 2022) |
| "Metformin poisoning with lactic acidosis is an uncommon yet clinically serious condition related to the inhibition of normal aerobic metabolism." | 5.22 | Continuous extracorporeal clearance in metformin-associated lactic acidosis and metformin-induced lactic acidosis: a systematic review. ( Correia, MS; Horowitz, BZ, 2022) |
| " However, if used in excessive doses for patients with kidney disease, it will be contraindicated with side effects such as lactic acidosis." | 5.22 | Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease. ( Rahman, F; Tuba, S, 2022) |
| "There is no evidence that the use of contrast media (CM) in diabetic patients with serum creatinine <130 μmole/L leads to metformin accumulation and subsequent lactic acidosis." | 5.15 | Monitoring metformin in cardiac patients exposed to contrast media using ultra-high-performance liquid chromatography tandem mass-spectrometry. ( Al Babtain, MA; Al Taweel, ES; Al-Amri, HS; Al-Moghairi, AM; Aloudah, NM; Radwan, MA, 2011) |
| "Metformin as first-line treatment in type 2 diabetes mellitus (T2 D) shows benefits in terms of reducing cardiovascular events, but the risk of a lactic acidosis as a serious adverse event especially in patients with decreased renal function is still relevant." | 5.12 | [Metformin Therapy During Surgical Interventions and Iodinated Contrast Agent Use]. ( Eisert, A; Freitag, M; Masur, S, 2021) |
| "Metformin was approved by the Food and Drug Administration in 1995 subject to the conduct of a randomized trial to evaluate the risk of lactic acidosis or other serious adverse events (SAEs) with this agent, under usual care conditions." | 5.11 | Comparative outcomes study of metformin intervention versus conventional approach the COSMIC Approach Study. ( Cryer, DR; Henry, DH; Mills, DJ; Nicholas, SP; Stadel, BV, 2005) |
| "Metformin-associated lactic acidosis (MALA) may occur after acute metformin overdose, or from therapeutic use in patients with renal compromise." | 5.05 | Do Patients Die with or from Metformin-Associated Lactic Acidosis (MALA)? Systematic Review and Meta-analysis of pH and Lactate as Predictors of Mortality in MALA. ( Benabbas, R; Blumenberg, A; Jeng, A; Sinert, R; Wiener, SW, 2020) |
| " Metformin and SGLT2 inhibitors should be discontinued in patients with severe forms of COVID-19 owing to the risks of lactic acidosis and ketoacidosis." | 5.05 | COVID-19 in diabetic patients: Related risks and specifics of management. ( Hermans, MP; Maiter, D; Orioli, L; Thissen, JP; Vandeleene, B; Yombi, JC, 2020) |
| "We performed a systematic search on PubMed, applying the following search terms: "acute metabolic acidosis," "lactic acidosis," "metformin" AND "acidosis," "unbalanced solutions" AND "acidosis," "bicarbonate" AND "acidosis" AND "outcome," "acute metabolic acidosis" AND "management," and "acute metabolic acidosis" AND "renal replacement therapy (RRT)/dialysis." | 5.05 | Etiology and Management of Acute Metabolic Acidosis: An Update. ( Matyukhin, I; Patschan, D; Patschan, S; Ritter, O, 2020) |
| "Metformin-associated lactic acidosis (MALA) is a rare adverse effect that has significant morbidity and mortality." | 5.05 | Osmolar-gap in the setting of metformin-associated lactic acidosis: Case report and a literature review highlighting an apparently unusual association. ( Alamin, M; Elshafei, MN; Mohamed, MFH, 2020) |
| "The second part of the review deals in detail with the diagnostics and treatment of toxic alcohols poisoning and management and indication of extracorporeal removal techniques in intoxication with other drugs, theophylline, valproic acid, metformin and metformin associated lactic acidosis, respectively." | 5.01 | Extracorporeal removal techniques in toxicology: part 2. ( Harazim, M; Horák, J; Matějovič, M; Raděj, J, 2019) |
| "There is increasing evidence to suggest that therapeutic doses of metformin are unlikely to cause lactic acidosis." | 5.01 | The Association between Metformin Therapy and Lactic Acidosis. ( Duffull, SB; Kuan, IHS; Savage, RL; Walker, RJ; Wright, DFB, 2019) |
| "The current practice concerning timing, mode, and dose of renal replacement therapy (RRT) in patients with metformin-associated lactic acidosis (MALA) with renal failure remains unknown." | 4.95 | Serum lactate level and mortality in metformin-associated lactic acidosis requiring renal replacement therapy: a systematic review of case reports and case series. ( Kuo, CC; Ting, IW; Tsai, CW; Wu, JY; Yeh, HC, 2017) |
| "Metformin has been associated with lactic acidosis." | 4.95 | Lactate Levels with Chronic Metformin Use: A Narrative Review. ( Castelino, RL; Huang, W; Peterson, GM, 2017) |
| "Metformin-associated lactic acidosis (MALA) is a rare but potentially fatal condition that can easily be avoided." | 4.95 | [Metformin-associated lactic acidosis: an insufficiently recognised problem]. ( Bosch, FH; Kramers, C; Manders, M; van Luin, M, 2017) |
| "Although metformin has become a drug of choice for the treatment of type 2 diabetes mellitus, some patients may not receive it owing to the risk of lactic acidosis." | 4.93 | Metformin-associated lactic acidosis: Current perspectives on causes and risk. ( Bicsak, TA; Chen, K; DeFronzo, R; Fleming, GA, 2016) |
| "Metformin (MF) accumulation during acute kidney injury is associated with high anion gap lactic acidosis type B (MF-associated lactic acidosis, MALA), a serious medical condition leading to high mortality." | 4.93 | Metformin associated lactic acidosis (MALA): clinical profiling and management. ( Coclite, D; Manzione, A; Maresca, B; Menè, P; Moioli, A; Napoletano, AM; Pirozzi, N; Punzo, G, 2016) |
| "Metformin poisoning with lactic acidosis appears to be amenable to extracorporeal treatments." | 4.91 | Extracorporeal Treatment for Metformin Poisoning: Systematic Review and Recommendations From the Extracorporeal Treatments in Poisoning Workgroup. ( Calello, DP; Ghannoum, M; Gosselin, S; Hoffman, RS; Lavergne, V; Liu, KD; Nolin, TD; Roberts, DM; Wiegand, TJ, 2015) |
| "The aim was to justify less restrictive use of metformin in stable chronic renal failure, because a literature review reveals metformin is associated with a significantly lower incidence of cardiovascular events and mortality compared with other hypoglycaemic agents, and metformin-associated lactic acidosis is rare and causation uncertain." | 4.90 | A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure. ( Adam, WR; O'Brien, RC, 2014) |
| "The aim of this study is to study the mortality rate in so-called "metformin-associated lactic acidosis" (MALA) from the 1960s to date and to establish whether the rate has changed over time." | 4.90 | Mortality rate in so-called "metformin-associated lactic acidosis": a review of the data since the 1960s. ( Kajbaf, F; Lalau, JD, 2014) |
| "Metformin is known to be rarely associated with lactic acidosis, a serious condition with a poor prognosis." | 4.89 | Metformin-associated lactic acidosis requiring hospitalization. A national 10 year survey and a systematic literature review. ( Ferrazin, F; Finco, G; Landoni, G; Mura, P; Pani, L; Renda, F, 2013) |
| "Data over the past decade refute the historical contraindication in patients with renal impairment and suggest that the risk of metformin-associated lactic acidosis is low in stable mild-to-moderate renal impairment and similar to the risk with other type 2 diabetes mellitus (DM2) medications with no renal impairment restrictions." | 4.89 | Unleash metformin: reconsideration of the contraindication in patients with renal impairment. ( Braun, A; Defilippi, J; Lu, WR, 2013) |
| "Metformin is widely prescribed for the treatment of type 2 diabetes mellitus and is associated with a reduction in diabetes-induced cardiovascular morbidity and mortality." | 4.88 | Discontinuation of metformin in the setting of coronary angiography: clinical uncertainty amongst physicians reflecting a poor evidence base. ( Gershlick, A; Maznyczka, A; Myat, A, 2012) |
| "Lactic acidosis in diabetic patients undergoing metformin therapy is a widely recognized, rare but usually serious adverse event, particularly in presence of comorbidities such as cardiorespiratory disease, sepsis and renal failure." | 4.88 | Iodine-based radiographic contrast medium may precipitate metformin-associated lactic acidosis in diabetic patients. A case report, literature review and practical approach. ( Tonolini, M, 2012) |
| "Metformin Associates lactic acidosis (MALA) is a metabolic acidosis with higher anion gap, high levels of blood lactates and treatment by metformin." | 4.88 | [Metformin associates lactic acidosis]. ( Jouzel, C; Mesnard, L; Montini, F; Peltier, J; Ridel, C; Rondeau, E, 2012) |
| "To systematically review evidence about the relationship between metformin administration and the use of iodinated contrast medium and risk of lactic acidosis (LA) and to assess the quality of five current guidelines for use of contrast medium in patients who are taking metformin." | 4.86 | Systematic review of current guidelines, and their evidence base, on risk of lactic acidosis after administration of contrast medium for patients receiving metformin. ( Compton, G; Goergen, SK; Harris, C; Rumbold, G, 2010) |
| " Metformin, however, is thought to increase the risk of lactic acidosis, and has been considered to be contraindicated in many chronic hypoxemic conditions that may be associated with lactic acidosis, such as cardiovascular, renal, hepatic and pulmonary disease, and advancing age." | 4.86 | Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. ( Greyber, E; Pasternak, GA; Salpeter Posthumous, EE; Salpeter, SR, 2010) |
| " Metformin, however, is thought to increase the risk of lactic acidosis, and has been considered to be contraindicated in many chronic hypoxemic conditions that may be associated with lactic acidosis, such as cardiovascular, renal, hepatic and pulmonary disease, and advancing age." | 4.86 | Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. ( Greyber, E; Pasternak, GA; Salpeter, EE; Salpeter, SR, 2010) |
| "Lactic acidosis associated with metformin treatment is a rare but important adverse event, and unravelling the problem is critical." | 4.86 | Lactic acidosis induced by metformin: incidence, management and prevention. ( Lalau, JD, 2010) |
| "Metformin is commonly used in diabetes mellitus type 2, with lactic acidosis being a rare but potentially fatal complication of this therapy." | 4.85 | Should dialysis be offered in all cases of metformin-associated lactic acidosis? ( Finkle, SN, 2009) |
| " Search terms included metformin, heart failure, lactic acidosis, clinical trials, and insulin resistance." | 4.84 | The safety of metformin in heart failure. ( Roberts, F; Ryan, GJ, 2007) |
| "Lactic acidosis in metformin use is a widely recognised but rare side effect." | 4.84 | Reality of severe metformin-induced lactic acidosis in the absence of chronic renal impairment. ( Bosch, FH; Bruijstens, LA; Buscher-Jungerhans, PM; van Luin, M, 2008) |
| "For fear of lactic acidosis the currently listed contraindications to the use of metformin exclude a large number of people with type 2 diabetes from efficacious anti-hyperglycemic and cardioprotective treatment." | 4.83 | [Traditional contraindications to the use of metformin -- more harmful than beneficial?]. ( Egberts, EH; Holstein, A, 2006) |
| "To assess the incidence of fatal and nonfatal lactic acidosis with metformin use compared to placebo and other glucose-lowering treatments in patients with type 2 diabetes mellitus." | 4.83 | Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. ( Greyber, E; Pasternak, G; Salpeter, E; Salpeter, S, 2006) |
| " The keywords were: lactic acidosis, metformin, biguanide, diabetes mellitus." | 4.83 | [Metformin-associated lactic acidosis]. ( Chatti, O; Ghaddab, A; Ichai, C; Orban, JC, 2006) |
| "To assess the incidence of fatal and nonfatal lactic acidosis with metformin use compared to placebo and other glucose-lowering treatments in patients with type 2 diabetes mellitus." | 4.82 | Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. ( Greyber, E; Pasternak, G; Salpeter, E; Salpeter, S, 2003) |
| "Metformin therapy for type 2 diabetes mellitus has been shown to reduce total mortality rates compared with other antihyperglycemic treatments but is thought to increase the risk of lactic acidosis." | 4.82 | Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis. ( Greyber, E; Pasternak, GA; Salpeter, EE; Salpeter, SR, 2003) |
| "Metformin has been associated with the serious side-effect lactic acidosis." | 4.82 | Metformin and lactic acidosis: cause or coincidence? A review of case reports. ( Erkelens, DW; Heikens, JT; Hoekstra, JB; Holleman, F; Stades, AM, 2004) |
| "To determine whether a causal or coincidental relationship is indicated in the literature between metaformin and lactic acidosis and to recommend clinical guidelines for the withdrawal of metformin prior to surgery." | 4.82 | Metformin lactic acidosis and anaesthesia: myth or reality? ( De Kock, M; Vreven, R, 2005) |
| "The link between metformin and lactic acidosis in metformin therapy may be causal, associated or coincidental." | 4.81 | Lactic acidosis in metformin therapy: searching for a link with metformin in reports of 'metformin-associated lactic acidosis'. ( Lalau, JD; Race, JM, 2001) |
| " The use of ICM in diabetic patients receiving metformin should be carried out with care to avoid metformin-induced lactic acidosis." | 4.81 | Adverse reactions to iodinated contrast media. ( Morcos, SK; Thomsen, HS, 2001) |
| "To assess the incidence of fatal and nonfatal lactic acidosis with metformin use compared to placebo and other glucose-lowering treatments in patients with type 2 diabetes mellitus." | 4.81 | Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. ( Greyber, E; Pasternak, G; Salpeter, E; Salpeter, S, 2002) |
| "An extensive literature search was conducted from both Medline and Ovid (1965-98) using the following keywords: 'Type 2 diabetes mellitus', 'oral hypoglycaemic drugs', 'biguanides', 'metformin-associated lactic acidosis' and 'renal impairment'." | 4.80 | Metformin-associated lactic acidosis: a rare or very rare clinical entity? ( Brain, HP; Chan, NN; Feher, MD, 1999) |
| "We present a patient with metformin associated lactic acidosis, to remind of a potentially lethal adverse reaction." | 4.80 | [Metformin associated lactic acidosis--case reports and literature review]. ( Dale, A; Fadnes, DJ; Løvås, K, 2000) |
| "Metformin-associated lactic acidosis is not necessarily due to metformin accumulation." | 4.80 | [Current role of metformin in treatment of diabetes mellitus type 2]. ( Janssen, JA, 2000) |
| "Use of the oral antidiabetic drug metformin may cause lactic acidosis, a rare but life-threatening complication, especially in patients with renal function loss." | 4.80 | [Prevention of lactic acidosis due to metformin intoxication in contrast media nephropathy]. ( de Bruin, TW; de Haan, M; Landewé-Cleuren, S; van Zwam, WH, 2000) |
| " On the other hand, treatment of obese patients with metformin significantly reduced the incidence of myocardial infarction and of mortality diabetes related." | 4.80 | [Should the occurrence of a first coronary event change the management of diabetes?]. ( Dubois-Laforgue, D; Timsit, J, 2000) |
| " The danger of lactic acidosis can be avoided with the use of metformin, the less toxic of biguanides, and strict respect for contraindications." | 4.77 | [Biguanides in the treatment of diabetes mellitus]. ( Saraiva, AM, 1989) |
| "Lactic acidosis is a disease in which lactic acid accumulates in the blood and causes acidosis in the patient." | 4.31 | Metformin-associated severe lactic acidosis combined with multi-organ insufficiency induced by infection with Aeromonas veronii: A case report. ( Wu, C; Xia, Y; Zhu, X, 2023) |
| "Metformin accumulation is associated with lactic acidosis and haemodynamic instability." | 4.31 | [Metformin-associated lactic acidosis]. ( Arthurson, C; Fjære, OL; Morberg, PCW; Ringdal, KG, 2023) |
| "A 53-year-old man died following a reported ingestion of 80 g of his metformin tablets resulting in severe, refractory shock and metformin-associated lactic acidosis." | 4.31 | Toxicokinetics of metformin overdose treated with CVVHDF. ( Brooks, D; Dion, C; Lewis, B; Schwebach, C, 2023) |
| "Metformin-associated lactic acidosis is a well-known metformin treatment complication; however, the development of euglycemic diabetic ketoacidosis (euDKA) has rarely been reported." | 4.31 | Severe lactic acidosis with euglycemic diabetic ketoacidosis due to metformin overdose. ( Fujimaru, T; Hifumi, T; Ito, Y; Kadota, N; Konishi, K; Kuno, H; Nagahama, M; Nakayama, M; Otani, N; Sekiguchi, M; Taki, F; Watanabe, K, 2023) |
| "Metformin metabolism is slowed down in T2DM patients in the hypoxic environment of the plateau; the glucose-lowering effect of the plateau is similar, and the attainment rate is low, the possibility of having serious adverse effects of lactic acidosis is higher in T2DM patients on the plateau than on the control one." | 4.31 | Effects of plateau hypoxia on population pharmacokinetics and pharmacodynamics of metformin in patients with Type 2 diabetes. ( Hu, L; Li, W; Luo, L; Luo, X; Qin, N; Shen, Y; Sun, Y; Wang, R; Wang, Z, 2023) |
| "Metformin-associated lactic acidosis (MALA) is a serious condition with high mortality." | 4.31 | Surviving cardiac arrest from severe metformin-associated lactic acidosis using extracorporeal membrane oxygenation and double continuous venovenous haemodialysis. ( Akkaoui, KK; Andersen, LV; Andreasen, JB; Nørgaard, MA, 2023) |
| "Metformin-induced lactic acidosis with acute kidney injury is rare but well known." | 4.31 | Daily dose of metformin caused acute kidney injury with lactic acidosis: a case report. ( Ariga, M; Hagita, J; Kitaichi, K; Oida, Y; Soda, M; Teramachi, H, 2023) |
| "Type B lactic acidosis is a rare but serious side effect of metformin use." | 4.31 | Treatment of severe metformin-associated lactic acidosis with renal replacement therapy and tris-hydroxymethyl aminomethane: a case report. ( Abdullin, M; Braden, GL; Hodgins, S; Landry, DL; Tiru, B; Yusim, D, 2023) |
| " Metabolic acidosis in a patient with a history of metformin intake should suggest the possibility of metformin-associated lactic acidosis, which must be treated immediately, without waiting for the results of other examinations, especially in patients with sudden blindness." | 4.31 | Reversible acute blindness in suspected metformin-associated lactic acidosis: a case report. ( Huang, R; Sun, W, 2023) |
| "Metformin associated lactic acidosis may potentially occur after combination with ribocilib, an uncommon but lethal complication from the interaction of these drugs, especially in patients who had preexisting renal impairment." | 4.12 | Lactic acidosis, a potential toxicity from drug-drug interaction related to concomitant ribociclib and metformin in preexisting renal insufficiency: A case report. ( Lagampan, C; Parinyanitikul, N; Poovorawan, N, 2022) |
| "Severe and life-threatening cases of metformin-associated lactic acidosis (MALA) are treated with renal replacement therapy." | 4.12 | Achieving High Dialysis Dose via Continuous Renal Replacement Therapy in the Setting of Metformin Associated Lactic Acidosis. A Case Series. ( Apte, YV; Pollock, HHG; Reynolds, HV; Tabah, A, 2022) |
| " We herein report a case of cardiac dysfunction due to thiamine deficiency after hemodialysis in a patient with suspected biguanide-related lactic acidosis." | 4.12 | Cardiac Dysfunction Due to Thiamine Deficiency after Hemodialysis for Biguanide-related Lactic Acidosis. ( Jimura, F; Kachi, N; Tamaki, H; Tsushima, H, 2022) |
| "BACKGROUND Metformin-associated lactic acidosis (MALA) is a relatively rare adverse effect of metformin therapy." | 4.12 | Transient Complete Blindness Due to Metformin-Associated Lactic Acidosis (MALA) Reversed with Hemodialysis. ( Barusya, C; Charokopos, A; Dumic, I; Knopps, L; Rueda Prada, L; Subramanian, A; Zurob, AS, 2022) |
| "Evidence of metformin-associated lactic acidosis (MALA) in advanced chronic kidney disease (CKD) has been limited due to high mortality rate but rare incidence rate." | 4.12 | Relationship between metformin use and lactic acidosis in advanced chronic kidney disease: The REMIND-TMU study. ( Chang, TH; Chen, C; Chen, CC; Chen, CH; Hung, YJ; Ke, SS; Ko, Y; Kuo, KN; Wei, TE, 2022) |
| "Metformin-associated lactic acidosis (MALA) is a rare but life-threatening condition." | 4.12 | A patient with severe metformin-associated lactic acidosis complicated by acute coronary syndrome: a case report. ( Ahmed, A; Gudowski, C; Mammadova, N; Pliquett, RU; Shkodivskyi, P; Soukup, J, 2022) |
| "Metformin-associated lactic acidosis (MALA) is an extremely rare but life-threatening adverse effect of metformin treatment." | 4.12 | Metformin-associated Lactic Acidosis with Hypoglycemia during the COVID-19 Pandemic. ( Hazama, Y; Irie, Y; Kosugi, M; Maruo, Y; Obata, Y; Takayama, K; Yamaguchi, H; Yasuda, T, 2022) |
| "Metformin-associated lactic acidosis (MALA) is a rare event but underrecognition may lead to unfavorable outcomes in type 2 diabetes patients." | 4.12 | Metformin-associated lactic acidosis and factors associated with 30-day mortality. ( Jayanama, K; Nongnuch, A; Parapiboon, W; Phonyangnok, B; Pichitporn, W; Sumrittivanicha, J; Sungkanuparph, S; Thammavaranucupt, K; Wongluechai, L, 2022) |
| "Lactic acidosis is the most important and life-threatening side effect of metformin that is widely used in the treatment of type 2 diabetes mellitus." | 4.02 | Continuous veno-venous hemodiafiltration in metformin-associated lactic acidosis caused by a suicide attempt: A report of two cases. ( Temizkan Kırkayak, AG; Tuncali, B; Zeyneloğlu, P, 2021) |
| " Here, we present a case of a diabetic patient with acute kidney injury, metformin-associated lactic acidosis, and COVID-19." | 4.02 | Metformin-associated lactic acidosis and acute kidney injury in the era of COVID-19. ( Kalaitzidis, RG; Koukoulaki, M; Theofilis, P; Vlachopanos, G; Vordoni, A, 2021) |
| "The aim of this case report is to specify the frequency and mortality of Metformin-Associated Lactic Acidosis (MALA) in emergency medicine, as the diagnosis seems to occur more often than estimated." | 4.02 | Metformin Associated Lactic Acidosis in Clinical Practice - A Case Series. ( Kellerer, M; Schädle, P; Tschritter, O, 2021) |
| "Although hemodialysis is recommended for patients with severe metformin-associated lactic acidosis (MALA), the amount of metformin removed by hemodialysis is poorly documented." | 4.02 | A Pharmacokinetic Analysis of Hemodialysis for Metformin-Associated Lactic Acidosis. ( Biary, R; Harding, SA; Hoffman, RS; Howland, MA; Su, MK, 2021) |
| "Metformin-associated lactic acidosis (MALA) is a widely documented adverse event of metformin." | 4.02 | The usefulness of measuring the anion gap in diagnosing metformin-associated lactic acidosis: a case series. ( Agra-Montava, I; Juanes-Borrego, A; Lozano-Polo, L; Mangues-Bafalluy, MA; Puig-Campmany, M; Ruiz-Ramos, J, 2021) |
| "Compare rates of lactic acidosis (LA) among metformin-exposed and unexposed patients with type 2 diabetes mellitus and varying degrees of chronic kidney disease (CKD)." | 4.02 | Lactic acidosis incidence with metformin in patients with type 2 diabetes and chronic kidney disease: A retrospective nested case-control study. ( Alvarez, CA; Chansard, M; Halm, EA; Hennessy, S; Lingvay, I; McGuire, DK; Miller, RT; Mortensen, EM; Pugh, MJV; Vouri, SM; Yang, H; Zullo, AR, 2021) |
| " Inhibition of mitochondrial respiration likely explains lactate formation in the brain during metformin infusion which may cause lactic acidosis during metformin intoxication." | 4.02 | Cholinergic and metabolic effects of metformin in mouse brain. ( Klein, J; Lau, H; Lehto, A; Piechotta, C; Thinnes, A; Westenberger, M; Wirth, F, 2021) |
| "Long-term use of metformin was associated with reduced risk of pneumonia and pneumonia-related death among Chinese individuals with diabetes." | 4.02 | Long-term metformin use and risk of pneumonia and related death in type 2 diabetes: a registry-based cohort study. ( Chan, JCN; Chow, E; Kong, APS; Lau, ESH; Luk, AOY; Ma, RCW; Shi, M; So, WY; Wu, H; Yang, A, 2021) |
| "The FDA approved 'label' for metformin lists hepatic insufficiency as a risk for lactic acidosis." | 3.96 | The safety and pharmacokinetics of metformin in patients with chronic liver disease. ( Braithwaite, HE; Carland, JE; Cheng, TS; Danta, M; Day, RO; Graham, GG; Greenfield, JR; Kumar, SS; Liu, Z; Smith, FC; Stocker, SL; Williams, KM, 2020) |
| "Metformin-associated lactic acidosis (MALA) is a difficult to diagnose and potentially life-threatening disease." | 3.96 | [Severe Metformin-Associated Lactic Acidosis in a 67-Year-Old Patient]. ( Keßler, M; Rattka, M; Rottbauer, W, 2020) |
| " The secondary outcome was metformin-associated lactic acidosis." | 3.96 | The Long-term Effects of Metformin on Patients With Type 2 Diabetic Kidney Disease. ( An, JN; Kim, CT; Kim, DK; Kim, YC; Kim, YS; Kwon, S; Lee, J; Lee, JP; Lim, CS; Oh, S; Oh, YK; Park, JY; Park, S, 2020) |
| "Metformin-associated lactic acidosis is rare despite its widespread use." | 3.96 | Successful Dialysis Treatment of Metformin Associated Lactic Acidosis, Report of Two Cases. ( Berekatoglu, N; Günay, E; Kalkan, Z; Selim Ay, M; Yaman, M; Yuksel, E, 2020) |
| "To assess whether extracorporeal treatment (ECTR) improves outcome of patients with metformin-associated lactic acidosis (MALA) and to evaluate the clinical applicability of the Extracorporeal Treatments in Poisoning Workgroup (EXTRIP) criteria for starting ECTR in metformin poisoning." | 3.96 | Extracorporeal treatment of metforminassociated lactic acidosis in clinical practice: a retrospective cohort study. ( de Meijer, A; Jansman, FGA; Taxis, K; van Berlo-van de Laar, IRF; van den Elsen-Hutten, M; Vermeij, CG, 2020) |
| "To compare the risk of lactic acidosis hospitalization between patients treated with metformin versus sulfonylureas following development of reduced kidney function." | 3.96 | Hospitalization for Lactic Acidosis Among Patients With Reduced Kidney Function Treated With Metformin or Sulfonylureas. ( Chipman, J; Chu, PY; Elasy, T; Greevy, RA; Griffin, MR; Grijalva, CG; Hackstadt, AJ; Hung, AM; Roumie, CL, 2020) |
| "Use of metformin increases plasma lactate concentration and may lead to metformin-associated lactic acidosis (MALA)." | 3.96 | Mortality and renal prognosis in isolated metformin-associated lactic acidosis treated with continuous renal replacement therapy and citrate-calcium-anticoagulation. ( Järvisalo, MJ; Uusalo, P, 2020) |
| "Metformin-associated lactic acidosis (MALA) is rarely encountered, but has a high mortality rate, Conventional treatments include hemodialysis or continuous renal replacement therapy (CRRT); however, when the disease progresses to end-stage, cardiac function is significantly inhibited, circulation cannot be maintained, CRRT cannot be tolerated, V-A extracorporeal membrane oxygenation (ECMO) may be the last treatment." | 3.96 | Extracorporeal membrane oxygenation with continuous renal replacement therapy to treat metformin-associated lactic acidosis: A case report. ( Chen, T; Liu, B; Zhu, C, 2020) |
| "Metformin-associated lactic acidosis (MALA) carries a high mortality rate." | 3.96 | Metformin-associated lactic acidosis: reinforcing learning points. ( Creagh, F; Goonoo, MS; Morris, R; Raithatha, A, 2020) |
| "Background Metformin associated lactic acidosis (MALA) is a serious adverse event with a high mortality rate of 30-50%." | 3.96 | Identifying patients with metformin associated lactic acidosis in the emergency department. ( de Meijer, A; Gedik, A; Jansman, FGA; Taxis, K; van 't Riet, E; van Berlo-van de Laar, IRF, 2020) |
| "To determine the plasma metformin concentration threshold associated with lactic acidosis and analyze the outcome in metformin-treated patients with lactic acidosis hospitalized in an emergency context." | 3.96 | A Study of Associations Between Plasma Metformin Concentration, Lactic Acidosis, and Mortality in an Emergency Hospitalization Context. ( Batteux, B; Bennis, Y; Bodeau, S; De Broe, ME; Gras-Champel, V; Lalau, JD; Lemaire-Hurtel, AS; Maizel, J; Masmoudi, K, 2020) |
| "Lactic acidosis is a feared complication of metformin therapy." | 3.96 | Metformin -associated lactic acidosis. ( Bláha, V; Lášticová, M; Šmahelová, A; Víšek, J; Zima, O, 2020) |
| " We report three cases of prospectively identified laboratory confirmed metformin-associated lactic acidosis admitted to our intensive care unit." | 3.91 | Laboratory-Confirmed Metformin-Associated Lactic Acidosis ( Canavan, C; Coyle, N; Nasim, S; Nestor, C, 2019) |
| "A 70-year-old Japanese woman with type 2 diabetes mellitus presented to an emergency room with metformin-associated lactic acidosis." | 3.91 | A patient with metformin-associated lactic acidosis successfully treated with continuous renal replacement therapy: a case report. ( Ando, M; Ariyoshi, K; Kinoshita, H; Tamura, R; Yanai, M, 2019) |
| "The choice of the specific modality and treatment duration of renal replacement therapy (RRT) to adopt in metformin-associated lactic acidosis (MALA) is still debated." | 3.91 | Sustained low-efficiency dialysis for metformin-associated lactic acidosis in patients with acute kidney injury. ( Fani, F; Ferioli, E; Fiaccadori, E; Gandolfini, I; Greco, P; Locatelli, C; Maccari, C; Maggiore, U; Parenti, E; Regolisti, G, 2019) |
| "To study the incidence of lactic acidosis due to metformin in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) stage 3-5." | 3.91 | Lactic acidosis due to metformin in type 2 diabetes mellitus and chronic kidney disease stage 3-5: is it significant? ( Guddattu, V; Mareddy, AS; Nagaraju, SP; Prabhu, RA; Rangaswamy, D, 2019) |
| " The primary outcomes were: (1) hyperlactatemia, defined as a lactate concentration ≥ 2 mmol/L at any point during hospital admission and, (2) metformin associated lactic acidosis (MALA), defined as a lactate concentration ≥ 5 mmol/L and pH <7." | 3.91 | Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose. ( Hoffman, RS; Manini, AF; Taub, ES, 2019) |
| "The use of metformin in patients with type 2 diabetes mellitus has been associated with lactic acidosis." | 3.91 | Lactic acidosis associated with metformin in patients with moderate to severe chronic kidney disease: study protocol for a multicenter population-based case-control study using health databases. ( Ávila, M; Gómez-Lumbreras, A; Manríquez, M; Morros, R; Pedrós, C, 2019) |
| "Metformin is a commonly used treatment modality in type 2 diabetes mellitus with lactic acidosis as a rare but life-threatening side effect." | 3.91 | Metformin-associated lactic acidosis treated successfully by peritoneal dialysis in a resource limited setting: case report. ( Ekpebegh, C; Elmezughi, K, 2019) |
| "Metformin-associated lactic acidosis is a rare but serious complication of taking metformin." | 3.91 | Metformin-Associated Lactic Acidosis Presenting Like Acute Mesenteric Ischemia. ( Hastings, C; Johnson, K; Slaven, E; Zhang, QC, 2019) |
| " We aimed to follow the variation of some biochemical and clinical parameters in T2D patients before and after Ramadan; and to determine the incidence of fasting on hypoglycaemia and lactic acidosis associated with antidiabetic agents such as metformin." | 3.91 | Follow-up of glycemic index before and after Ramadan fasting in type 2 diabetes patients under antidiabetic medications. ( Abdessadek, M; Ajdi, F; Khabbal, Y; Magoul, R; Marmouzi, I, 2019) |
| "Pharmacokinetic data suggest that the risk of metformin-associated lactic acidosis (MALA) may be increased after Roux-en-Y gastric bypass (RYGB) surgery." | 3.88 | Risk of Metformin-Associated Lactic Acidosis (MALA) in Patients After Gastric Bypass Surgery. ( Aarts, EO; Aelfers, SCW; Berends, FJ; de Boer, H; Deden, LN; Janssen, IMC; van Borren, MMGJ, 2018) |
| "In the general population, the absolute risk of lactic acidosis in patients treated with metformin appears to be low." | 3.88 | Safety of Metformin Therapy in Patients with Type 2 Diabetes Living on an Oxygen-Deficient Plateau, Tibet, China. ( Geng, Y; Lv, X; Meng, S; Mina, A; Puchi, B; Ren, Q; Song, J; Yang, L; Yang, S; Zhou, L, 2018) |
| "Metformin-associated lactic acidosis (MALA) is a rare complication among patients who are diabetic, commonly presenting with non-specific findings, and developing mostly among those with other risk factors for lactic acidosis." | 3.88 | Metformin-associated lactic acidosis mimicking ischaemic bowel. ( Ali, S; Azarov, N; Hindi, Z; Labuschagne, H; Oud, L, 2018) |
| "A new diagnostic paradigm has been proposed to better categorize causes of Metformin-Associated Lactic Acidosis (MALA)." | 3.88 | Metformin-Induced Lactic Acidosis (MILA): Review of current diagnostic paradigm. ( Al-Khalisy, H; Kaul, P; Krowl, L, 2018) |
| "The most important reason of the mortality in patients who has metformin intoxication is metformin-associated lactic acidosis (MALA)." | 3.88 | Clinical and Laboratory Features of Metformin Intoxication in Suicidal Patients Attending an Intensive Care Unit. ( Akca, O; Avci, D; Cetinkaya, A; Erden, A; Gunal, AI; Kalan, U; Ozer, O, 2018) |
| "Metformin associated lactic acidosis (MALA) is a well-known serious side effect of biguanides." | 3.88 | Metformin associated lactic acidosis: a case series of 28 patients treated with sustained low-efficiency dialysis (SLED) and long-term follow-up. ( Angioi, A; Atzeni, A; Cabiddu, G; Cao, R; Conti, M; Floris, M; Matta, V; Mulas, MF; Pani, A; Pili, G; Rosner, M; Songini, M, 2018) |
| " As the risk of inducing lactic acidosis is very low in connection with administration of iodine contrast media, new recommendations in Sweden say that metformin must be stopped only when GFR is below 45 mL/min." | 3.88 | [Treatment with metformin in type 2 diabetes mellitus - new routines when renal function is reduced and in connection with administration of iodine contrast media]. ( Frid, A; Sterner, G, 2018) |
| "To report a case of severe lactic acidosis and hypoglycemia due to acute metformin intoxication in a dog." | 3.88 | Severe lactic acidosis and hypoglycemia due to acute metformin intoxication in a dog. ( Borchers, A; Ueda, Y; Wong, C, 2018) |
| "To estimate the incidence rate of lactic acidosis in patients with type 2 diabetes mellitus as well as to estimate the relative risk of lactic acidosis associated with metformin treatment." | 3.88 | Risk of lactic acidosis in type 2 diabetes patients using metformin: A case control study. ( Aharaz, A; Beck-Nielsen, H; Hallas, J; Henriksen, DP; Lassen, AT; Pottegård, A, 2018) |
| "The application of iodinated contrast medium has become a risk factor for metformin-associated lactic acidosis (MALA), which leads to the accumulation of metformin in vivo is one of the principal reasons for MALA." | 3.88 | Involvement of organic cation transporter 2 in the metformin-associated increased lactate levels caused by contrast-induced nephropathy. ( Dai, Y; Huo, X; Liu, K; Liu, Z; Ma, X; Meng, Q; Peng, J; Sun, H; Wang, C; Yang, S, 2018) |
| "Metformin toxicity is well known to cause lactic acidosis." | 3.88 | Recurrent hypoglycemia secondary to metformin toxicity in the absence of co-ingestions: a case report. ( Aldobeaban, S; Alshehri, AA; Mzahim, B, 2018) |
| "Metformin is an antidiabetic drug; used to treat type II diabetes mellitus, metformin associated lactic acidosis has an incidence of 2-9 cases / 100,000 patients / year with high mortality (30%)." | 3.88 | [A case of severe metformin-associated lactic acidosis treated with CVVHDF and regional anticoagulation with sodium citrate]. ( Apicella, A; Beretta, E; Della Morte, M; Ferrario, M, 2018) |
| " Metformin-associated lactic acidosis (MALA) is one such rare, life-threatening adverse drug effect." | 3.88 | Metformin-associated lactic acidosis precipitated by liraglutide use: adverse effects of aggressive antihyperglycaemic therapy. ( Hannallah, F; Hooda, A; Mehta, A, 2018) |
| "Danish national guidelines recommend discontinuation of metformin 48 h prior to general anaesthesia due to the presumed increased risk of lactic acidosis." | 3.88 | [Metformin and surgery before general anaesthesia]. ( Beck-Nielsen, H; Bonde, C; Jensen, DH; Lauritzen, E, 2018) |
| "Metformin is renally excreted and has been associated with the development of lactic acidosis." | 3.85 | Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study. ( Connelly, PJ; Donnelly, L; Lonergan, M; Pearson, ER; Soto-Pedre, E; Zhou, K, 2017) |
| "Chronic metformin treatment mildly increases lactate level, but does not induce hyperlactatemia or lactic acidosis in acute illness on the first day of admission to an internal medicine ward." | 3.85 | Metformin Does Not Induce Hyperlactatemia in Patients Admitted to Internal Medicine Ward. ( Doenyas-Barak, K; Golik, A; Koren, R; Koren, S; Zilberman-Itskovich, S, 2017) |
| "Whether metformin precipitates lactic acidosis in patients with chronic kidney disease (CKD) remains under debate." | 3.85 | Risk of acute kidney injury and survival in patients treated with Metformin: an observational cohort study. ( Bell, S; Colhoun, HM; Farran, B; Leese, GP; Lindsay, R; Looker, H; McCrimmon, RJ; McGurnaghan, S; McKeigue, P; McKnight, J; Petrie, JR; Sattar, N; Wild, S, 2017) |
| "Metformin associated lactic acidosis (MALA) is a rare but lethal complication." | 3.85 | Metformin is not associated with lactic acidosis in patients with diabetes undergoing coronary artery bypass graft surgery: a case control study. ( Alburikan, KA; Nazer, RI, 2017) |
| "In renal failure metformin can lead to lactic acidosis." | 3.85 | Combined metformin-associated lactic acidosis and euglycemic ketoacidosis. ( Eisner, F; Eller, K; Eller, P; Lind, A; Mader, JK; Pieber, TR; Plank, J; Schilcher, G; Schwetz, V, 2017) |
| "Metformin-associated lactic acidosis is a severe and infrequent adverse event." | 3.85 | [Metformin-associated lactic acidosis. Report of one case]. ( Dreyse, J; Orozco, R; Pezzani, MJ; Quintana, F; Regueira, T; Soto, L, 2017) |
| "To assess risk of lactic acidosis among metformin users compared with other glucose-lowering agent users, according to renal function." | 3.85 | Metformin use and risk of lactic acidosis in people with diabetes with and without renal impairment: a cohort study in Denmark and the UK. ( Christiansen, CF; Ehrenstein, V; Gopalakrishnan, C; Heide-Jørgensen, U; Jick, S; Li, L; Nørrelund, H; Sørensen, HT, 2017) |
| " There was no difference in prevalence of hyperlactatemia and lactic acidosis between the patients with and without metformin use (18." | 3.85 | Association between Metformin Use and Risk of Lactic Acidosis or Elevated Lactate Concentration in Type 2 Diabetes. ( Cha, BS; Han, E; Hwang, S; Kang, ES; Kang, HP; Lee, BW; Lee, EY; Lee, HC; Lee, SH; Lee, W; Lee, YH; Lee, YM, 2017) |
| "Metformin-associated lactic acidosis (MALA) is a rare but life-threatening complication." | 3.85 | Metformin-associated lactic acidosis treated with continuous renal replacement therapy. ( Imai, H; Katayama, N; Nakamura, A; Suzuki, K, 2017) |
| "Metformin intoxication with lactic acidosis, a potentially lethal condition, may develop in diabetic patients when the drug dose is inappropriate and/or its clearance is reduced." | 3.85 | Treatment of Metformin Intoxication Complicated by Lactic Acidosis and Acute Kidney Injury: The Role of Prolonged Intermittent Hemodialysis. ( Antoniotti, R; Fani, F; Fiaccadori, E; Greco, P; Regolisti, G, 2017) |
| "Metformin-associated lactic acidosis (MALA) is a rare but life-threatening adverse drug reaction of metformin, the most frequently prescribed medication for patients with type 2 diabetes mellitus." | 3.83 | Metformin-Associated Lactic Acidosis Presenting as Acute ST-Elevation Myocardial Infarction. ( Cole, JB; Driver, BE; White, S, 2016) |
| "Metformin-associated lactic acidosis (MALA) is one of the most important drug toxicities with a high morbidity and mortality rate." | 3.83 | Myocardial injury and acute renal failure associated with lactic acidosis due to suicide attempt with metformin. ( Berber, E; Ordu, O; Ozdemir, A; Ozen, B; Sertbas, M; Sertbas, Y, 2016) |
| "The role of metformin in the development of lactic acidosis (LA) in the setting of acute renal failure (ARF) is debated." | 3.83 | Dose-related effects of metformin on acid-base balance and renal function in patients with diabetes who develop acute renal failure: a cross-sectional study. ( Angelini, C; Badalamenti, S; Calvetta, A; Cucchiari, D; Merizzoli, E; Morenghi, E; Podestà, MA; Ponticelli, C, 2016) |
| " Thus, in patients with diabetes-associated chronic kidney disease, the glucose lowering therapy has to account for renal function to avoid hypoglycemic episodes and other side effects such as lactic acidosis due to metformin." | 3.83 | [New aspects in prevention and therapy of diabetic nephropathy]. ( Böger, CA; Büttner, R; Rheinberger, M, 2016) |
| "The role of metformin in lactic acidosis is regularly questioned." | 3.83 | Lactic acidosis: relationship between metformin levels, lactate concentration and mortality. ( Altman, JJ; Boucaud-Maitre, D; Bouhanick, B; Doucet, J; Emmerich, J; Girardin, E; Kaloustian, E; Lassmann Vague, V; Porokhov, B; Ropers, J, 2016) |
| "To evaluate the strength of association between lactic acidosis (LA) and well-recognized risk factors for LA, particularly the weight of metformin." | 3.83 | Lactic Acidosis in Diabetic Population: Is Metformin Implicated? Results of a Matched Case-Control Study Performed on the Type 2 Diabetes Population of Grenoble Hospital University. ( Chanoine, S; Giai, J; Lepelley, M; Villier, C; Yahiaoui, N, 2016) |
| "A 72-year-old woman with a history of type 2 diabetes mellitus was brought to the ER with metformin-associated lactic acidosis." | 3.83 | A Fatal Case of Metformin-associated Lactic Acidosis. ( Fujita, Y; Hamada, T; Kawato, R; Minatoguchi, S; Murai, Y; Nomura, A; Oyama, Y; Ozeki, T; Ryuge, A; Shimizu, H; Takasugi, K; Tomino, T; Watanabe, M, 2016) |
| "In conclusion, our findings support the low risk of MALA among patients with mild-to-moderate renal impairment and the likelihood of metformin to be an innocent bystander without a pathogenic role in the lactic acidosis in most cases." | 3.83 | Retrospective analysis of lactic acidosis-related parameters upon and after metformin discontinuation in patients with diabetes and chronic kidney disease. ( Acikgoz, SB; Genc, AB; Nalbant, A; Sipahi, S; Solak, Y; Tamer, A; Yildirim, M; Yilmaz, U, 2016) |
| "Lactic acidosis during metformin intoxication is classically mainly attributed to diminished lactate clearance through liver gluconeogenesis." | 3.83 | Skeletal muscle lactate overproduction during metformin intoxication: An animal study with reverse microdialysis. ( Bassani, G; Ferrero, S; Gattinoni, L; Guenzani, S; Langer, T; Magnoni, S; Properzi, P; Protti, A; Santini, A; Stocchetti, N, 2016) |
| "We report a case of metformin-associated lactic acidosis (MALA) in the setting of normal renal function and review the relevant medical literature." | 3.83 | Metformin-Associated Lactic Acidosis in a Patient with Normal Renal Function. ( Ellen, R; Omar, A; Sorisky, A, 2016) |
| "To estimate the incidence of lactic acidosis (LA) and role of metformin in Japanese patients with type 2 diabetes mellitus (T2DM) treated with anti-diabetes drugs." | 3.83 | Epidemiology of lactic acidosis in type 2 diabetes patients with metformin in Japan. ( Chang, CH; Dolin, P; Sakaguchi, M, 2016) |
| "Overdosing of the oral antidiabetic metformin in impaired renal function is an important contributory cause to life-threatening lactic acidosis." | 3.83 | Development, implementation and outcome analysis of semi-automated alerts for metformin dose adjustment in hospitalized patients with renal impairment. ( Bucklar, G; Gött, C; Jödicke, A; Krattinger, R; Niedrig, D; Russmann, S, 2016) |
| "We report a case of metformin-associated lactic acidosis (MALA) in a 66-year-old man with end-stage renal disease on peritoneal dialysis (PD)." | 3.83 | Peritoneal dialysis treatment of metformin-associated lactic acidosis in a diabetic nephropathy patient . ( Gao, J; Gu, Z; Na, Y; Xu, Y, 2016) |
| "The principal objective of this study was to retrospectively review a series of cases of lactic acidosis (LA) in patients with type 2 diabetes mellitus (T2DM) and examine the relationship with the use of metformin." | 3.83 | Lactic acidosis and the relationship with metformin usage: Case reports. ( Castelino, RL; Huang, W; Peterson, GM, 2016) |
| "Metformin, a biguanide drug, is emerging as an important treatment option for the prevention or treatment of weight gain, type 2 diabetes mellitus, and the metabolic syndrome in psychiatric patients, especially those who require or receive antipsychotic drugs." | 3.83 | Use of Metformin for Cardiometabolic Risks in Psychiatric Practice: Need-to-Know Safety Issues. ( Andrade, C, 2016) |
| "Lactic acidosis is the most severe adverse effect associated with metformin therapy of type 2 diabetes mellitus." | 3.83 | [Lactic acidosis due to metformin accumulation complicating acute gastroenteritis]. ( DŽupová, O; Kulichová, J, 2016) |
| " Metformin - an oral hypoglycemic drug universally recommended as the first-line treatment for type 2 diabetes mellitus (T2DM) - undergoes significant accumulation in advanced CKD that may ultimately lead to lactic acidosis." | 3.81 | Prescription-medication sharing among family members: an unrecognized cause of a serious drug adverse event in a patient with impaired renal function. ( Makówka, A; Nowicki, M; Zawiasa, A, 2015) |
| "Although metformin-associated lactic acidosis is well described, there is less information on metformin overdose and whether it is of similar severity." | 3.81 | Hyperlactataemia and clinical severity of acute metformin overdose. ( Isbister, GK; McNamara, K, 2015) |
| "The March 2012 regulatory action issued by the Japanese government signalled the rare but serious complication of lactic acidosis that can occur during metformin treatment, especially with the high dose formulation, h-metformin, and in those above 75 years old." | 3.81 | Impact of Japanese regulatory action on metformin-associated lactic acidosis in type II diabetes patients. ( Hanatani, T; Sai, K; Saito, Y; Segawa, K; Tohkin, M, 2015) |
| "Metformin-induced lactic acidosis is a rare but severe disease for the individual patients." | 3.81 | [Metformin-induced lactic acidosis : Severe symptoms with difficult diagnostics]. ( Brenner, T; Decker, SO; Hofer, S; Siegler, BH; Ulrich, A; Wortmann, M, 2015) |
| " However, due to its rare association with lactic acidosis, its safety in COPD is uncertain." | 3.81 | Safety of metformin in patients with chronic obstructive pulmonary disease and type 2 diabetes mellitus. ( Archer, JR; Baker, EH; Hitchings, AW; Srivastava, SA, 2015) |
| "Metformin-associated lactic acidosis or lacticemia has been widely reported as an adverse drug effect in diabetic patients with other significant comorbidities and in acute overdose in adults." | 3.81 | Lacticemia After Acute Overdose of Metformin in an Adolescent Managed Without Intravenous Sodium Bicarbonate or Extracorporeal Therapy. ( Bebarta, VS; Pead, J; Varney, SM, 2015) |
| " All cases of lactic acidosis (pH, ≤ 7." | 3.80 | Metformin accumulation: lactic acidosis and high plasmatic metformin levels in a retrospective case series of 66 patients on chronic therapy. ( Giampreti, A; Locatelli, CA; Lonati, D; Manzo, L; Papa, P; Petrolini, VM; Protti, A; Rocchi, L; Rognoni, C; Rolandi, L; Valli, A; Vecchio, S, 2014) |
| "In a number of patients, the antidiabetic drug metformin has been associated with lactic acidosis." | 3.80 | Metformin in peritoneal dialysis: a pilot experience. ( Abdul-Rahman, IS; Al-Hwiesh, AK; Al-Mohanna, FA; Divino-Filho, JC; El-Deen, MA; Gupta, KL; Larbi, E, 2014) |
| "The objective of this study was to determine whether treatment with metformin in patients with renal impairment is associated with a higher risk of lactic acidosis or elevated lactate concentrations compared with users of a noninsulin antidiabetic drug (NIAD) who had never used metformin." | 3.80 | Risk of lactic acidosis or elevated lactate concentrations in metformin users with renal impairment: a population-based cohort study. ( De Smet, PA; de Vries, F; Derijks, HJ; Egberts, A; Eppenga, WL; Geerts, AF; Lalmohamed, A; Wensing, M, 2014) |
| "Two patients with type 2 DM developed acute kidney injury and lactic acidosis following colonoscopy despite withholding metformin." | 3.80 | Acute renal failure and metformin-associated lactic acidosis following colonoscopy. ( Connor, SJ; Depczynski, B; Hall, BM; Hussain, MI, 2014) |
| "To determine whether the use of metformin in type 2 diabetic patients with various kidney functions is associated with an increased risk of lactic acidosis (LA)." | 3.80 | Incidence of lactic acidosis in patients with type 2 diabetes with and without renal impairment treated with metformin: a retrospective cohort study. ( Corvino, FA; Gottwald-Hostalek, U; Guedes, S; Richy, FF; Sabidó-Espin, M, 2014) |
| "Metformin-associated lactic acidosis is a diagnosis by exclusion; however, a high degree of clinical suspicion supplemented by prompt multisystem organ support can significantly influence the outcome in critically ill patients." | 3.80 | Metformin-associated lactic acidosis presenting as an ischemic gut in a patient who then survived a cardiac arrest: a case report. ( Ncomanzi, D; Sicat, RM; Sundararajan, K, 2014) |
| "There is controversy surrounding the risk of metformin and the development of lactic acidosis." | 3.80 | Pharmacist review prevents evolving metformin-associated lactic acidosis. ( Kyle, G; Naunton, M; Naunton-Boom, K; Owoka, F, 2014) |
| "Lactic acidosis is a well-known complication of the anti-hyperglycemic biguanide agent metformin, especially in peculiar but not rare clinical conditions." | 3.80 | Metformin-associated lactic acidosis and temporary ileostomy: a case report. ( Margiani, C; Mura, P; Restivo, A; Saba, M; Scintu, F; Zorcolo, L, 2014) |
| " There was concomitant ACE inhibitor (ACEi) use and metformin toxicity with severe lactic acidosis." | 3.79 | Feeling blue with metformin-associated lactic acidosis. ( Parker, A; Plumb, B; Wong, P, 2013) |
| "Lactic acidosis is a well-recognized consequence of metformin." | 3.79 | Metformin overdose-induced hypoglycemia in the absence of other antidiabetic drugs. ( Al-Abri, SA; Hayashi, S; Olson, KR; Thoren, KL, 2013) |
| "Lactic acidosis is an adverse event associated with metformin usage." | 3.79 | The Role of Metformin in Metformin-Associated Lactic Acidosis (MALA): Case Series and Formulation of a Model of Pathogenesis. ( Day, RO; Duong, JK; Furlong, TJ; Graham, GG; Greenfield, JR; Roberts, DM; Williams, KM, 2013) |
| "Analysis of the prognostic values of blood pH and lactate and plasma metformin concentrations in severe metformin-associated lactic acidosis may help to resolve the following paradox: metformin provides impressive, beneficial effects but is also associated with life-threatening adverse effects." | 3.79 | The prognostic value of blood pH and lactate and metformin concentrations in severe metformin-associated lactic acidosis. ( Kajbaf, F; Lalau, JD, 2013) |
| " The recommandation of its early management with metformin by the majority of guidelines has made metformin the object of multiple studies to demonstrate its benefits, but more importantly its side effects among whom the most serious is lactic acidosis." | 3.79 | [Toxicity of metformin, pro- or con- a future restriction to its contraindications?]. ( Décosterd, D; Wakim El Khoury, J, 2013) |
| "The aim of this study was to evaluate the frequency of metformin-associated lactic acidosis in our metformin-intoxicated patients, the general approach for their management, and determine the frequency of hypoglycemia and outcome in these patients." | 3.79 | Metformin toxicity: a report of 204 cases from Iran. ( Askari, A; Barzi, F; Ebrahimian, K; Hassanian-Moghaddam, H; Shadnia, S; Zamani, N, 2013) |
| "Lactic acidosis is a rare but severe complication in patients with type 2 diabetes treated with metformin." | 3.79 | Metformin-induced lactic acidosis associated with multiorganic failure. ( Bajrami, V; Barbullushi, M; Bolleku, E; Idrizi, A; Likaj, E; Nunci, L; Ohri, I; Thereska, N, 2013) |
| "To study the quality of pharmacovigilance reporting in cases of so-called 'metformin-associated lactic acidosis' and, ultimately, whether or not the criteria for this condition are indeed met." | 3.79 | The criteria for metformin-associated lactic acidosis: the quality of reporting in a large pharmacovigilance database. ( Kajbaf, F; Lalau, JD, 2013) |
| "Metformin associated lactic acidosis (MALA) is a serious complication occurring especially in elderly patients given high doses of the drug." | 3.79 | Monitoring of metformin-induced lactic acidosis in a diabetic patient with acute kidney failure and effect of hemodialysis. ( Amiel, JB; Laforest, C; Merle, L; Pichon, N; Saint-Marcoux, F, 2013) |
| "The existence of metformin-induced lactic acidosis has been questioned, in particular in the absence of specific risk factors such as impaired renal function." | 3.78 | Metformin-associated lactic acidosis in a patient with normal kidney function. ( Brouwers, MC; Pijpers, E; Stehouwer, CD; van Sloten, TT, 2012) |
| " Metformin-associated lactic acidosis may sometimes be life-threatening." | 3.78 | Metformin-associated lactic acidosis following acute kidney injury. Efficacious treatment with continuous renal replacement therapy. ( Dahan, E; Dichtwald, S; Ekstein, MP; Sorkine, P; Weinbroum, AA, 2012) |
| "Lactic acidosis is a fatal adverse effect of metformin, but the risk factor remains unclear." | 3.78 | Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis. ( Fujimoto, S; Hosokawa, M; Inagaki, N; Inui, K; Katsura, T; Masuda, S; Osawa, R; Toyama, K; Yonezawa, A, 2012) |
| "Metformin therapy is limited in patients with chronic kidney disease (CKD) due to the potential risk of lactic acidosis." | 3.78 | Metformin therapy in patients with chronic kidney disease. ( Day, RO; Duong, JK; Furlong, TJ; Graham, GG; Greenfield, JR; Kirkpatrick, CM; Kumar, SS; Roberts, DM; Williams, KM, 2012) |
| "Hepatic mitochondrial dysfunction may play a critical role in the pathogenesis of metformin-induced lactic acidosis." | 3.78 | Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs. ( Comi, GP; De Giuseppe, R; Fortunato, F; Gatti, S; Gattinoni, L; Monti, M; Protti, A; Vecchio, S, 2012) |
| " He was diagnosed with metformin-associated lactic acidosis and acute kidney injury." | 3.78 | Toxicokinetics of metformin-associated lactic acidosis with continuous renal replacement therapy. ( Agarwala, R; Anderson, H; Cheng, JT; Geara, AS; Madhrira, M; Mohan, S; Mujtaba, M, 2012) |
| " We present a case of a 65-year-old Caucasian man who presented with metformin associated lactic acidosis." | 3.78 | Survival after cardiopulmonary arrest with extreme hyperkalaemia and hypothermia in a patient with metformin-associated lactic acidosis. ( Lee, IL; Tay, S, 2012) |
| "To evaluate the significance of diabetes mellitus and metformin in patients admitted to medical ICU with lactic acidosis." | 3.78 | Lactic acidosis in medical ICU - the role of diabetes mellitus and metformin. ( Charvat, J; Havlin, J; Hloch, O; Masopust, J, 2012) |
| "We describe two cases of severe metformin-related lactic acidosis with underlying acute kidney injury, which were treated with dialysis." | 3.77 | Metformin-related lactic acidosis in patients with acute kidney injury. ( Devetzis, V; Georgoulidou, A; Panagoutsos, S; Passadakis, P; Theodoridis, M; Thodis, E; Vargemezis, V, 2011) |
| "Metformin has long been thought to cause lactic acidosis (LA) but evidence from various sources has led researchers to question a direct causative relationship." | 3.77 | Diabetes, metformin and lactic acidosis. ( Harvey, JN; Scale, T, 2011) |
| "We present an uncommon case of lactic acidosis after concomitant administration of Metformin and Tenofovir." | 3.77 | Lactic acidosis after concomitant treatment with metformin and tenofovir in a patient with HIV infection. ( Alivanis, P; Aperis, G; Arvanitis, A; Paliouras, C; Zervos, A, 2011) |
| " Two cases of lactic acidosis due to ingestion of high dose metformin for suicidal purposes have been presented here; in both cases, clinical improvement was seen with bicarbonate hemodialysis." | 3.77 | Dialysis therapy for lactic acidosis caused by metformin intoxication: presentation of two cases. ( Aytemiz, E; Begenik, H; Emre, H; Erkoc, R; Ozturk, M; Soyoral, YU, 2011) |
| "Lactic acidosis is a rare and often lethal complication of metformin therapy." | 3.77 | Prolonged hemodialysis for severe metformin intoxication. ( Juvvadi, R; McFarren, C; Rifkin, SI; Weinstein, SS, 2011) |
| "The reported incidence of metformin associated lactic acidosis (MALA) in type 2 diabetes mellitus (DM) is 3-9 cases per 100,000 patient-years." | 3.77 | Metformin associated lactic acidosis: incidence and clinical correlation with metformin serum concentration measurements. ( Doorenbos, CJ; van Berlo-van de Laar, IR; Vermeij, CG, 2011) |
| "Metformin-associated lactic acidosis (MALA) is a severe metabolic failure with high related mortality." | 3.77 | Management of metformin-associated lactic acidosis by continuous renal replacement therapy. ( Argaud, L; Cour, M; Hernu, R; Illinger, J; Keller, G; Robert, D, 2011) |
| " Intoxication is associated with lactic acidosis and has significant clinical consequences." | 3.77 | Metformin intoxication requiring dialysis. ( Concepcion, L; Nguyen, HL, 2011) |
| "Lactic acidosis can develop during biguanide (metformin and phenformin) intoxication, possibly as a consequence of mitochondrial dysfunction." | 3.76 | Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication. ( Foti, G; Gattinoni, L; Mistraletti, G; Protti, A; Rossi, A; Rudiger, A; Russo, R; Singer, M; Tagliabue, P; Vecchio, S, 2010) |
| " We present the case of a patient who developed acute renal failure and lactic acidosis while using creatine and metformin simultaneously." | 3.76 | Severe metabolic acidosis secondary to coadministration of creatine and metformin, a case report. ( Mani, M; Saidi, H, 2010) |
| "Lactic acidosis has been considered to be a side effect of some biguanides, after phenformin was withdrawn from the market because of its association with lactic acidosis." | 3.76 | Comparison of potential risks of lactic acidosis induction by biguanides in rats. ( Bando, K; Deguchi, J; Funabashi, H; Kimura, J; Kunimatsu, T; Ochiai, S; Seki, T, 2010) |
| "Metformin-associated lactic acidosis (MALA) is well described in patients taking therapeutic metformin who develop renal failure or other serious comorbid conditions." | 3.76 | Can acute overdose of metformin lead to lactic acidosis? ( Bryant, SM; Buckley, P; Seo, B; Wills, BK, 2010) |
| "Metformin associated lactic acidosis (MALA) is a rare condition with a prevalence of 3 per 100,000 patient-years." | 3.76 | [Metformin treatment causes persisting lactic acidosis after cardiac arrest]. ( Gamst, J; Hansen, LK; Rasmussen, BS, 2010) |
| "Metformin associated lactic acidosis (MALA) may complicate metformin therapy, particularly if metformin accumulates due to renal dysfunction." | 3.76 | Outcome of severe lactic acidosis associated with metformin accumulation. ( Abel, P; Felix, SB; Friesecke, S; Roser, M; Runge, S, 2010) |
| "Metformin, a widely used hypoglycaemic agent in type 2 diabetes mellitus, is uncommonly associated with lactic acidosis, a serious condition with high mortality." | 3.76 | Metformin-associated lactic acidosis (MALA): clinical profile and outcomes in patients admitted to the intensive care unit. ( Biradar, V; Moran, JL; Peake, SL; Peter, JV, 2010) |
| "Metformin, widely used in the treatment of diabetes mellitus, is known to cause lactic acidosis in both therapeutic use and after an overdose." | 3.76 | Metformin overdose with a resultant serum pH of 6.59: survival without sequalae. ( Algren, DA; Dell'Aglio, DM; Morgan, BW; Perino, LJ; Todino, JD, 2010) |
| "To investigate the treatment of massive metformin overdose associated with lactic acidosis." | 3.75 | Severe metformin intoxication treated with prolonged haemodialyses and plasma exchange. ( Erdur, B; Sari, I; Tura, P; Turkcuer, I; Yuksel, A; Yuksel, S, 2009) |
| "In this patient, lactic acidosis was promoted by erlotinib-related hepatitis with initial liver failure (decreased lactate clearance), concomitant metformin treatment (increased lactate production), and acute renal deterioration (metformin accumulation)." | 3.75 | Erlotinib-induced hepatitis complicated by fatal lactic acidosis in an elderly man with lung cancer. ( Fimognari, FL; Franco, A; Pastorelli, R; Pellegrinotti, M; Repetto, L, 2009) |
| "From January 2004 to November 2008, 11 cases of metformin-associated lactic acidosis were seen at a medical center in Taiwan." | 3.75 | Impact of acute kidney injury on metformin-associated lactic acidosis. ( Wen, YK, 2009) |
| "Metformin-associated lactic acidosis is a very rare but critical condition." | 3.75 | Successful treatment of severe lactic acidosis caused by a suicide attempt with a metformin overdose. ( Lin, HD; Lin, KH; Lo, SH; Wang, LM; Yang, PW, 2009) |
| " Because patient compliance may be affected when media sensationalism about controversial findings is misunderstood, we sought to clarify the recent controversy surrounding the cardiovascular and bone-health risks of thiazolidinediones, the risk of lactic acidosis with metformin, and the risk of hypoglycemia with oral therapies." | 3.75 | Balancing risk and benefit with oral hypoglycemic drugs. ( Hamnvik, OP; McMahon, GT, 2009) |
| "Metformin-associated lactic acidosis is a rare and serious complication of biguanide treatment." | 3.75 | Metformin-associated lactic acidosis: a prognostic and therapeutic study. ( Fourrier, F; Houdret, N; Nseir, S; Seidowsky, A, 2009) |
| "A 74-year-old man with cardiac failure and renal impairment was admitted to the cardiothoracic intensive care unit with metformin-induced lactic acidosis and shock." | 3.75 | Continuous venovenous haemodiafiltration for metformin-induced lactic acidosis. ( MacLaren, G; Pan, LT, 2009) |
| "In case of impaired consciousness, metabolic acidosis with wide anion gap and elevated lactate levels a metformin associated lactic acidosis should be considered in diabetic patients." | 3.75 | [Female patient with type 2 diabetes in coma with metabolic acidosis]. ( Conrad, T; zur Nieden, T, 2009) |
| "The relationship among metformin use, plasma lactate levels, and lactic acidosis in patients with type 2 diabetes mellitus and the appropriateness of metformin use in patients with renal dysfunction are discussed." | 3.75 | Metformin use in renal dysfunction: is a serum creatinine threshold appropriate? ( Ernst, ME; McDanel, DL; Moores, KG; Philbrick, AM; Ross, MB, 2009) |
| " The effect of GFJ on glucose tolerance and metformin-induced lactic acidosis in normal, non-diabetic in rats is hereby investigated." | 3.75 | Grapefruit juice improves glycemic control but exacerbates metformin-induced lactic acidosis in non-diabetic rats. ( Ojewole, JA; Owira, PM, 2009) |
| "Metformin is a commonly used oral antidiabetic drug which can cause lactic acidosis." | 3.75 | How to explain a PaO2 of 140 mmHg in a venous line? ( Corno, L; Fichera, M; Landoni, G; Mizzi, A; Nuzzi, M; Zangrillo, A, 2009) |
| "The case history is presented of a patient who developed metformin-associated lactic acidosis." | 3.74 | Heeding clues to metformin-associated lactic acidosis: prompt response can save life. ( Chennavir, B; Gopi, A; Kumar, U, 2008) |
| "Lactic acidosis has been associated with use of metformin." | 3.74 | Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis. ( Bodmer, M; Jick, SS; Krähenbühl, S; Meier, C; Meier, CR, 2008) |
| "As a class, the biguanides induce lactic acidosis, a hallmark of mitochondrial impairment." | 3.74 | Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro. ( Billis, PA; Dykens, JA; Jamieson, J; Marroquin, L; Nadanaciva, S; Will, Y, 2008) |
| "Metformin-associated lactic acidosis (MALA) is a classic side effect of metformin and is known to be a severe disease with a high mortality rate." | 3.74 | Metformin-associated lactic acidosis in an intensive care unit. ( Barraud, D; Bollaert, PE; Cravoisy, A; Gibot, S; Jay, N; Nace, L; Peters, N, 2008) |
| "We report the case of a 46-yr-old male who developed severe lactic acidosis, cardiorespiratory arrest, and rhabdomyolysis following an overdose of metformin and ramipril." | 3.74 | Severe lactic acidosis and rhabdomyolysis following metformin and ramipril overdose. ( Bramham, K; Galea, M; Jelacin, N; White, I, 2007) |
| "A French analysis of reports of adverse effects shows that lactic acidosis due to metformin is preventable." | 3.74 | Metformin: preventable lactic acidosis. ( , 2007) |
| "We suspect that the life-threatening complication of metformin-associated lactic acidosis, solely due to drug accumulation following renal impairment, occurs more frequently than that previously reported and is not necessarily associated with other predisposing factors for lactic acidosis." | 3.74 | Metformin-associated lactic acidosis in patients with renal impairment solely due to drug accumulation? ( Felix, SB; Friesecke, S; Mayerle, J; Robinson, D; Roser, M; Runge, S; Warnke, C, 2008) |
| "Risk determinants for the life threatening complication of metformin-associated lactic acidosis are frequently disregarded." | 3.74 | Prevalence of risk determinants for metformin-associated lactic acidosis and metformin utilization in the study of health in pomerania. ( Alte, D; Baumeister, SE; Runge, S; Völzke, H, 2008) |
| "To determine the incidence of lactic acidosis in community-based patients with type 2 diabetes, with special reference to metformin therapy." | 3.74 | Metformin and lactic acidosis in an Australian community setting: the Fremantle Diabetes Study. ( Bruce, DG; Davis, TM; Davis, WA; Kamber, N, 2008) |
| "Metformin-associated lactic acidosis is a rare but serious condition and potentially even more hazardous during pregnancy." | 3.74 | Metformin-associated lactic acidosis in a pregnant patient. ( Chen, IC; Hong, YC; Hsiao, CT; Kuan, JT; O'Boyle, CP, 2008) |
| "In this report of a near-fatal metformin ingestion successfully treated with alkalinization and high-volume hemofiltration, we discuss the management of severe lactic acidosis and demonstrate that early aggressive intervention resulted in a positive outcome." | 3.73 | Severe lactic acidosis complicating metformin overdose successfully treated with high-volume venovenous hemofiltration and aggressive alkalinization. ( Harvey, B; Hickman, C; Hinson, G; Mayer, A; Ralph, T, 2005) |
| "Lactic acidosis is a known adverse risk of metformin treatment." | 3.73 | Fulminant lactic acidosis in two patients with Type 2 diabetes treated with metformin. ( Brassøe, R; Elkmann, T; Gravholt, CH; Hempel, M, 2005) |
| " This is largely due to the historical experience of lactic acidosis with phenformin, despite the fact that metformin does not predispose to this when compared with other therapies." | 3.73 | Contraindications can damage your health--is metformin a case in point? ( Holstein, A; Stumvoll, M, 2005) |
| "Metformin-associated lactic acidosis (MALA) is a rare but serious clinical entity." | 3.73 | Metformin-associated lactic acidosis precipitated by acute renal failure. ( Shenoy, C, 2006) |
| "The increasing prevalence of Type 2 diabetes and its treatment with metformin might result in more cases of lactic acidosis." | 3.73 | Severe acidosis in patients taking metformin--rapid reversal and survival despite high APACHE score. ( Grant, I; McKnight, JA; Nyirenda, MJ; Price, G; Sandeep, T, 2006) |
| " The concomitant use of metformin may lead to lactic acidosis due to metformin accumulation." | 3.73 | [Nephrotoxicity after the use of intravenous X-ray contrast media in a type 2 diabetic being treated with metformin]. ( Bjarnason, NH; Elung-Jensen, T, 2006) |
| "Lactic acidosis is an infrequent complication of metformin therapy for diabetes mellitus." | 3.73 | Metformin-associated lactic acidosis treated with continuous renal replacement therapy. ( Alivanis, P; Arvanitis, A; Giannikouris, I; Paliuras, C; Volanaki, M; Zervos, A, 2006) |
| "We present 5 patients with DM2 and HT who developed severe metformin-associated lactic acidosis in a setting with acute renal failure, precipitated by dehydration and aggravated by the use of ACEI or ARB." | 3.73 | Metformin and antihypertensive therapy with drugs blocking the renin angiotensin system, a cause of concern? ( Aksnes, H; Froyshov, S; Gudmundsdottir, H; Heldal, K; Krogh, A; Os, I; Rudberg, N, 2006) |
| "Biguanides are a class of drugs widely used as oral antihyperglycemic agents for the treatment of type 2 diabetes mellitus, but they are associated with lactic acidosis, a lethal side effect." | 3.72 | Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. ( Jonker, JW; Kato, Y; Kusuhara, H; Schinkel, AH; Sugiyama, Y; Wang, DS, 2003) |
| "In type II diabetes treated with metformin, lactic acidosis is a rare but severe complication." | 3.72 | [Metformin-associated lactic acidosis precipitated by acute renal failure]. ( Azoulay, E; Galy-Floc'h, M; Mariot, J; Pertek, JP; Vidal, S, 2003) |
| "We report 4 cases of lactic acidosis in diabetic patients usually treated with metformin." | 3.72 | [Metformin-associated lactic acidosis remains a serious complication of metformin therapy]. ( Giunti, C; Grimaud, D; Ichai, C; Levraut, J; Orban, JC, 2003) |
| "A patient with acute renal failure associated with lactic acidosis as a result of concurrent treatment with metformin is described." | 3.72 | Metformin lactic acidosis, acute renal failure and rofecoxib. ( Price, G, 2003) |
| "Lactic acidosis is a recognised complication of the antihyperglycaemic biguanide agent metformin, especially in patients with renal failure." | 3.72 | Unexpected survival from severe metformin-associated lactic acidosis. ( de Gooijer, A; Schure, PJ; van Zanten, AR, 2003) |
| "The major risk associated with metformin is lactic acidosis." | 3.72 | Toxic effects from metformin exposure. ( Quadrani, DA; Spiller, HA, 2004) |
| "Metformin is widely used in the treatment of type 2 diabetes, though it is recognized to be associated with the risk of lactic acidosis." | 3.72 | Experiences of a poison center with metformin-associated lactic acidosis. ( Sacha Weilemann, L; Sauer, O; von Mach, MA, 2004) |
| "Metformin is commonly prescribed to treat type 2 diabetes mellitus, however it is associated with the potentially lethal condition of lactic acidosis." | 3.72 | Do risk factors for lactic acidosis influence dosing of metformin? ( Cottrell, N; Green, B; Millican, S, 2004) |
| "Metformin Associated Lactic Acidosis (MALA) is a rare, but serious complications of Type 2 diabetes mellitus treatment with a mortality rate of around 50%." | 3.71 | An unusual case of metformin associated lactic acidosis. ( Poulose, V, 2002) |
| "A case of metformin-associated lactic acidosis after elective spinal surgery is reported." | 3.71 | Metformin-associated lactic acidosis after elective cervical spine fusion: a case report. ( Brager, MD; Lipsett, PA; Mears, SC; Riley, LH, 2002) |
| "A rare side effect from metformin is lactic acidosis." | 3.71 | [Metformin and contrast media--increased risk of lactic acidosis?]. ( Draganov, B; Kløw, NE; Os, I, 2001) |
| "The risk of lactic acidosis during metformin therapy is linked to specific and well-documented conditions that constitute contraindications or precautions to use of the agent." | 3.71 | Evaluation of prescribing practices: risk of lactic acidosis with metformin therapy. ( Calabrese, AT; Coley, KC; DaPos, SV; Rao, RH; Swanson, D, 2002) |
| " A case of metformin induced lactic acidosis is described where the presenting pH was 6." | 3.71 | Recovery from pH 6.38: lactic acidosis complicated by hypothermia. ( Ahmad, S; Beckett, M, 2002) |
| "Metformin-induced lactic acidosis is a common side effect in patients with renal insufficiency." | 3.71 | [Metformin-associated lactic acidosis with acute renal failure in type 2 diabetes mellitus]. ( Berner, B; Hagenlocher, S; Hummel, KM; Kleine, P; Müller, GA; Ramadori, G; Ritzel, U; Strutz, F, 2002) |
| "Recently, concern has been expressed about the hazards of lactic acidosis following the use of intravascular iodinated contrast agents in patients taking metformin." | 3.70 | Clinical risk associated with contrast angiography in metformin treated patients: a clinical review. ( Chan, P; Cleveland, T; Gaines, PA; Nawaz, S, 1998) |
| "Intravascular administration of iodinated contrast media to patients who are receiving metformin, an oral antidiabetic agent, can result in lactic acidosis." | 3.70 | Metformin and contrast media: where is the conflict? ( Hammond, DI; Rasuli, P, 1998) |
| "To provide a context for the interpretation of lactic acidosis risk among patients using metformin, we measured rates of lactic acidosis in patients with type 2 diabetes before metformin was approved for use in the U." | 3.70 | Lactic acidosis rates in type 2 diabetes. ( Barzilay, J; Brown, JB; Herson, MK; Latare, P; Pedula, K, 1998) |
| "The antidiabetic drug metformin has been associated in a small number of patients with lactic acidosis, a serious condition with a poor prognosis." | 3.70 | Lactic acidosis in metformin-treated patients. Prognostic value of arterial lactate levels and plasma metformin concentrations. ( Lalau, JD; Race, JM, 1999) |
| "The purpose of this study was to establish guidelines on how to avoid metformin-induced lactic acidosis following intravascular use of contrast media." | 3.70 | Contrast media and metformin: guidelines to diminish the risk of lactic acidosis in non-insulin-dependent diabetics after administration of contrast media. ESUR Contrast Media Safety Committee. ( Morcos, SK; Thomsen, HS, 1999) |
| "The purpose of this study was to determine the incidence of lactic acidosis in a geographically defined population of metformin users." | 3.70 | Incidence of lactic acidosis in metformin users. ( Butler-Jones, D; Stang, M; Wysowski, DK, 1999) |
| "The biguanide drugs metformin and phenformin have been linked in the past to lactic acidosis, a metabolic condition associated with high rates of mortality." | 3.70 | Lactic acidosis in metformin therapy. ( Lalau, JD; Race, JM, 1999) |
| " This was due to a severe lactic acidosis caused by acute alcohol intoxication and the use of metformin." | 3.70 | [Severe lactic acidosis due to metformin therapy in a patient with contra-indications for metformin]. ( Holman, ND; Houwerzijl, EJ; Snoek, WJ; van Haastert, M, 2000) |
| "To investigate the role of metformin accumulation in the pathophysiology of metformin-associated lactic acidosis." | 3.69 | Role of metformin accumulation in metformin-associated lactic acidosis. ( Bleichner, G; Chauveau, P; Compagnon, P; de Cagny, B; Dulbecco, P; Guérin, C; Haegy, JM; Lacroix, C; Lalau, JD; Rigaud, JP, 1995) |
| "To determine the respective role of metformin accumulation and tissue hypoxia in triggering metformin-associated lactic acidosis (MALA), we measured plasma (PM) and red blood cell (RM) metformin concentrations in 14 patients with MALA and in 58 diabetic patients on well-tolerated chronic metformin treatment." | 3.69 | Metformin-associated lactic acidosis in diabetic patients with acute renal failure. A critical analysis of its pathogenesis and prognosis. ( De Cagny, B; Fournier, A; Lacroix, C; Lalau, JD, 1994) |
| "A 69-year-old diabetic woman with diffuse atherosclerosis presented with acute renal failure due to contrast nephropathy and severe metformin-induced lactic acidosis." | 3.69 | Metformin-induced lactic acidosis associated with acute renal failure. ( Ben-Yehuda, A; Dranitzki-Elhalel, M; Popovtzer, M; Safadi, R, 1996) |
| "Treatment with metformin is occasionally associated with the development of severe lactic acidosis." | 3.69 | Contraindications to metformin therapy in patients with NIDDM. ( Bosman, D; Krentz, AJ; Sulkin, TV, 1997) |
| "Lactic acidosis associated with diabetic patients receiving metformin therapy is rare but may cause significant morbidity and mortality." | 3.68 | Metformin-induced lactic acidosis: report of a case. ( Huang, CC; Lim, PS; Wei, JS, 1992) |
| "Lactic acidosis is an extremely rare but serious complication of treatment with metformin." | 3.68 | [Lactic acidosis associated with metformin]. ( Lebech, M; Olesen, LL, 1990) |
| "Lactic acidosis in diabetics on metformin therapy is rare but still associated with poor prognosis." | 3.67 | Bicarbonate haemodialysis: an adequate treatment for lactic acidosis in diabetics treated by metformin. ( Coevoet, B; Debussche, X; Dkissi, H; Fournier, A; Lalau, JD; Quichaud, J; Temperville, B; Tolani, M; Westeel, PF, 1987) |
| "A 55 year old diabetic women treated with chlorpropamide and metformin for three years presented with acute oliguric renal failure and lactic acidosis from which she died." | 3.67 | Lactic acidosis due to metformin therapy in a low risk patient. ( Leatherdale, BA; Tymms, DJ, 1988) |
| "Iodixanol was the only contrast media which in all patients." | 2.87 | Is it necessary to discontinue metformin in diabetic patients with GFR > 60 ml/min per 1.73 m2 undergoing coronary angiography: A controversy still exists? ( Abdi, F; AlipourParsa, S; Esmaeeli, S; Khaheshi, I; Namazi, MH; Roohigilani, K; Safi, M; Vakili, H; Zare, A, 2018) |
| "Metformin is a wonder drug used as an anti-hypoglycemic medication; it is also used as a cancer suppression medicament." | 2.82 | Metformin as an emerging concern in wastewater: Occurrence, analysis and treatment methods. ( Balakrishnan, A; Jacob, MM; Sillanpää, M; Vo, DN, 2022) |
| "Metformin is an oral antihyperglycemic drug widely used to treat type 2 diabetes mellitus (T2DM), acting via indirect activation of 5' Adenosine monophosphate-activated Protein Kinase (AMPK)." | 2.72 | Mechanism and application of metformin in kidney diseases: An update. ( Meng, X; Song, A; Zhang, C, 2021) |
| "Metformin is a dimethyl-biguanide, also used in type 2 diabetes, that lowers fasting blood glucose primarily by decreasing hepatic glucose output." | 2.69 | Rosiglitazone does not alter the pharmacokinetics of metformin. ( Allen, A; Carr, A; Di Cicco, RA; Fowles, S; Freed, MI; Jorkasky, DK, 2000) |
| "Phenformin was once used to lower blood glucose levels, but later withdrawn from the market in several countries because it was frequently associated with lactic acidosis." | 2.66 | A review of phenformin, metformin, and imeglimin. ( Fraser-Spears, R; Kim, SS; La-Viola, B; Ramsinghani, S; Sikazwe, D; Witte, AP; Yendapally, R, 2020) |
| "Metformin is a frontline hypoglycemic agent, which is mainly prescribed to manage type 2 diabetes mellitus with obesity." | 2.66 | Metformin: the updated protective property in kidney disease. ( Chen, X; Guo, F; Liao, S; Liu, HF; Lu, X; Pan, Q; Yang, C; Zhao, C, 2020) |
| "Metformin, the first choice drug for type 2 diabetes treatment in all stages of therapy, and one of the most widely prescribed anti-hyperglycemic agents worldwide, represents a rare example of an old drug which continues to display new beneficial effects in various fields." | 2.61 | Metformin lactic acidosis: Should we still be afraid? ( Adinolfi, LE; Imbriani, S; Marfella, R; Monaco, L; Nevola, R; Pafundi, PC; Ricozzi, C; Rinaldi, L; Salvatore, T; Sardu, C; Sasso, FC, 2019) |
| "The prevalence of type 2 diabetes mellitus (T2D) has risen in the United States and worldwide, with an increase in global prevalence from 4." | 2.61 | SGLT2 inhibitors and metformin: Dual antihyperglycemic therapy and the risk of metabolic acidosis in type 2 diabetes. ( Donnan, K; Segar, L, 2019) |
| "Metformin has been shown to exert beneficial effects on the kidney in various clinical trials and experimental studies performed in divergent rodent models representing different types of renal diseases going from AKI to CKD." | 2.58 | Metformin: A Candidate Drug for Renal Diseases. ( Corremans, R; D'Haese, PC; Neven, E; Verhulst, A; Vervaet, BA, 2018) |
| "Metformin is a first-line therapy in patients with Type 2 diabetes, as it appears to be effective in reducing diabetes related end points and mortality in overweight patients." | 2.55 | Could metformin be used in patients with diabetes and advanced chronic kidney disease? ( Abraham, G; Chowdhury, TA; Fan, SL; McCafferty, K; Oei, EL; Srirathan, D; Yaqoob, MM, 2017) |
| "Clinicians and patients with type 2 diabetes enjoy an expanding list of medications to improve glycemic control." | 2.50 | Systematic reviews to ascertain the safety of diabetes medications. ( Brito, JP; Gionfriddo, MR; Leppin, AL; Montori, VM; Morey-Vargas, OL; Murad, MH, 2014) |
| "Metformin has traditionally been regarded as contraindicated in chronic kidney disease (CKD), though guidelines in recent years have been relaxed to permit therapy if the glomerular filtration rate (GFR) is > 30 mL/min." | 2.50 | Metformin in chronic kidney disease: time for a rethink. ( Heaf, J, 2014) |
| "However, lactic acidosis is always associated with acute events, such as hypovolemia, acute cardiorespiratory illness, severe sepsis and acute renal or hepatic failure." | 2.48 | [Proposal for the modification of metformin use in patients with chronic kidney disease]. ( Balogh, Z; Mátyus, J, 2012) |
| " In fact, the evidence supports the safe use of appropriate doses of metformin in patients with chronic stable renal impairment, and highlights the important possible greater risks of the alternatives, most notably severe hypoglycaemia in patients taking sulphonylureas and/or insulin and fluid retention in patients taking a thiazolidinedione." | 2.47 | Metformin: the safest hypoglycaemic agent in chronic kidney disease? ( Herrington, WG; Nye, HJ, 2011) |
| "Metformin is a biguanide, insulin sensitiser that reduces blood sugar levels." | 2.46 | Metformin: safety in cardiac patients. ( Khurana, R; Malik, IS, 2010) |
| "Metformin is a biguanide, insulin sensitiser that reduces blood sugar levels." | 2.46 | Metformin: safety in cardiac patients. ( Khurana, R; Malik, IS, 2010) |
| "Metformin is an oral antidiabetic agent, used to reduce blood glucose concentration in patients with non-insulin-dependent diabetes mellitus." | 2.46 | Perioperative use of metformin in cardiac surgery. ( Kapturauskas, J; Kinduris, S; Samalavičius, R; Sirvinskas, E, 2010) |
| "Metformin is known to cause potentially fatal metabolic acidosis with an increased lactate level in both overdose and therapeutic use." | 2.45 | Acute metformin overdose: examining serum pH, lactate level, and metformin concentrations in survivors versus nonsurvivors: a systematic review of the literature. ( Abramson, J; Dell'Aglio, DM; Kazzi, Z; Morgan, BW; Perino, LJ; Schwartz, MD, 2009) |
| "Lactic acidosis is a rare, serious adverse effect of metformin, which can be prevented by carefully observing the contra-indications." | 2.41 | [Metformin efficacious in poorly controlled diabetes mellitus type 2]. ( Hoekstra, JB; Holleman, F; Stades, AM, 2000) |
| "Metformin does not increase lactate production from skeletal muscle and has little clinically significant effect on vitamin B12 and folic acid absorption." | 2.40 | Metformin: a safe and effective treatment in the management of NIDDM. ( Kilo, C, 1997) |
| "Metformin is a sage and effective drug for management of non-insulin-dependent diabetes mellitus." | 2.40 | Metformin. ( Bell, PM; Hadden, DR, 1997) |
| "Metformin is a biguanide used to treat type II diabetes mellitus." | 2.40 | Metformin and contrast media--a dangerous combination? ( Gilbert, FJ; McCartney, MM; McHardy, K; Murchison, LE; Murray, AD; Pearson, D, 1999) |
| "Metformin has been used for over 40 years as an effective glucose-lowering agent in type 2 (noninsulin-dependent) diabetes mellitus." | 2.40 | A risk-benefit assessment of metformin in type 2 diabetes mellitus. ( Bailey, CJ; Howlett, HC, 1999) |
| "The biguanides are a class of oral hypoglycemic agents that are commonly used in the treatment of diabetes mellitus." | 2.38 | Biguanide-associated lactic acidosis. Case report and review of the literature. ( Arieff, AI; Barr, J; Gan, SC; Pearl, RG, 1992) |
| "MetforminHydrochloride is an antidiabetic used for many years, currently; it considered the first choice in treatment of type 2 diabetes (T2D)." | 1.91 | [Cross-Sectional Study on Adverse Effects of Metformin Hydrochloride on 130 Patients Type 2 Diabetic Admitted to Medical Center and Diabetes Home of Sidi Bel-Abbès]. ( Belakhdar, K; Kraroubi, A; Matmour, D; Sakouhi, M, 2023) |
| "A 40-year-old man with sensorineural hearing loss and diabetes mellitus was hospitalized with acute-onset impaired consciousness and clumsiness in his left hand." | 1.91 | Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes diagnosed after metformin-triggered stroke-like episodes. ( Ishiguchi, H; Ito, H; Murakami, K; Sakamoto, K, 2023) |
| "Metformin usage was defined as the use of metformin for>90 days after kidney transplantation; 1,193 KTRs were metformin users, and 802 KTRs did not use metformin." | 1.91 | Metformin Use and Long-term Clinical Outcomes in Kidney Transplant Recipients. ( Cho, JH; Jeong, JC; Jung, IM; Kim, CD; Kim, Y; Kim, YC; Kim, YH; Kim, YS; Kwon, H; Kwon, S; Lee, H; Lee, JP; Lee, JS; Lee, W; Lim, CS; Son, HE; Yoo, KD, 2023) |
| "Metformin is the first-line treatment used for type 2 diabetes mellitus for more than 60 years." | 1.72 | Relationship Between Plasmatic Metformin Concentration and Renal Replacement Therapy: A Multicenter Cohort Study. ( Claisse, G; Crepet, F; Delavenne, X; Demaretz, L; Fanton-D'Andon, C; Gonzalo, P; Herda, A; Launay, M; Mariat, C; Marin, C, 2022) |
| "Lactic acidosis was present in 2 patients at presentation and serum lactate was elevated in 7/15 patients tested." | 1.72 | The extrapyramidal syndromes of chronic kidney disease and dialysis (EPS-CKDD): diagnostic criteria, risk factors and prognosis. ( Agarwal, A; Chemmanam, T; Irish, AB; Manickavasagar, R; Prentice, DA; Youssef, A, 2022) |
| "Abnormal glucose metabolism in cancer cells causes generation and secretion of excess lactate, which results in acidification of the extracellular microenvironment." | 1.62 | Metformin induced lactic acidosis impaired response of cancer cells towards paclitaxel and doxorubicin: Role of monocarboxylate transporter. ( Bhat, MK; Chaube, B; Deb, A; Malvi, P; Mayengbam, SS; Mohammad, N; Singh, A; Singh, SV, 2021) |
| "Both obesity and type 2 diabetes (T2D) are recognized risk factors for developing a more severe form of COVID-19, with a higher death rate." | 1.62 | [Continuing or stopping metformin in patients with type 2 diabetes exposed to SARS-CoV-2 ?] ( Paquot, N; Scheen, AJ, 2021) |
| "A 58-year-old female with known type 2 diabetes mellitus continued to take her usual medications, including metformin, an ACE inhibitor and a non-steroidal anti-inflammatory drug, while suffering from diarrhoea and vomiting." | 1.62 | Metformin-associated lactic acidosis. ( Fadden, EJ; Longley, C; Mahambrey, T, 2021) |
| "Metformin overdose has been known as a risk of lactic acidosis, and previous reports have demonstrated that continuous renal replacement therapy(CRRT) is effective." | 1.56 | [Lactic Acidosis after Cardiac Surgery Treated by Continuous Renal Replacement Therapy in a Patient on Metformin;Report of a Case]. ( Matsumura, N; Nitta, Y; Saito, M; Yoshida, S, 2020) |
| "Metformin is the drug of choice in the treatment of type 2 diabetes mellitus." | 1.56 | Perioperative management of metformin: is there something new? ( Gregorová, J; Kovačič, M; Linhartová, A; Murínová, I, 2020) |
| "Metformin is commonly used for the treatment of type 2 diabetes mellitus." | 1.51 | Reversible Acute Blindness in Suspected Metformin-Associated Lactic Acidosis. ( Ham, YR; Jeong, WJ; Oh, SK; Ryu, S; Son, SH; You, YH, 2019) |
| " Oral parameters were separated from disposition parameters as dose-dependent absolute bioavailability was determined with support from urine data." | 1.51 | Using a semi-mechanistic model to identify the main sources of variability of metformin pharmacokinetics. ( Brøsen, K; Christensen, MMH; Guiastrennec, B; Kjellsson, MC; Stage, TB; Wellhagen, G, 2019) |
| "The prevalence of type 2 diabetes (T2D) continues to rise across the world." | 1.51 | Metformin overdose: A serious iatrogenic complication-Western France Poison Control Centre Data Analysis. ( Boels, D; Hadjadj, S; Hamel, JF; Stevens, A; Toure, A, 2019) |
| " To describe a concentration range in clinical samples after chronic use of metformin, metformin serum concentrations were determined in serum samples of 95 diabetic patients receiving daily doses of 500mg-3000mg of metformin." | 1.48 | Range of therapeutic metformin concentrations in clinical blood samples and comparison to a forensic case with death due to lactic acidosis. ( Hess, C; Madea, B; Stratmann, B; Tschoepe, D; Unger, M, 2018) |
| "Metformin is a common and generally well-tolerated medication in the treatment of diabetes but rarely has been implicated as the cause for metformin-associated lactate acidosis." | 1.48 | Hemodialysis in metformin-associated lactic acidosis due to acute overdose in a metformin-naïve patient. ( Baker, S; McCabe, DJ; Stellpflug, SJ, 2018) |
| "A recent study of advanced diabetic kidney disease patients in Taiwan in Lancet Endocrinology and Diabetes has provided unique insight into the potential consequences of unrestricted metformin use, including a 35% higher adjusted mortality risk that was dose-dependent." | 1.46 | Risks of Metformin in Type 2 Diabetes and Chronic Kidney Disease: Lessons Learned from Taiwanese Data. ( Kalantar-Zadeh, K; Kovesdy, CP; Rhee, CM, 2017) |
| "Metformin is a first-line oral antidiabetic therapy for patients with type 2 diabetes mellitus." | 1.46 | Hemodialysis-refractory metformin-associated lactate acidosis with hypoglycemia, hypothermia, and bradycardia in a diabetic patient with belated diagnosis and chronic kidney disease . ( Zibar, K; Zibar, L, 2017) |
| "Thirty (39%) patients suffered cardiac arrest before admission." | 1.43 | Prognosis of patients presenting extreme acidosis (pH <7) on admission to intensive care unit. ( Allou, N; Allyn, J; Brulliard, C; Combe, P; Galliot, R; Jabot, J; Martinet, O; Tabatchnik, X; Vandroux, D, 2016) |
| "Metformin users were similar to nonusers with respect to levels of lactate, HCO3, and blood pH; however, they were older and had higher incidence rates of cardiovascular disease and acute kidney injury at admission, compared to nonusers." | 1.43 | Lactic acidosis and severe septic shock in metformin users: a cohort study. ( Beberashvili, I; Doenyas-Barak, K; Efrati, S; Marcus, R, 2016) |
| "Metformin is a basic drug used for the treatment of type 2 diabetes mellitus." | 1.43 | [Chronic kidney diseases, metformin and lactic acidosis]. ( Borbély, Z, 2016) |
| "Metformin treatment inhibited both EMT markers and Oxphos and, when its concentration raised to 10 mM, it induced a striking inhibition of proliferation and colony formation of acidic melanoma cells, both grown in protons enriched medium or lactic acidosis." | 1.43 | Metformin is also effective on lactic acidosis-exposed melanoma cells switched to oxidative phosphorylation. ( Bianchini, F; Calorini, L; Del Rosso, M; Giannoni, E; Margheri, F; Peppicelli, S; Toti, A, 2016) |
| "Metformin is and has been considered as first-line therapy for type 2 diabetes for over a quarter of a century." | 1.43 | Should Restrictions Be Relaxed for Metformin Use in Chronic Kidney Disease? No, We Should Never Again Compromise Safety! ( Kalantar-Zadeh, K; Kovesdy, CP, 2016) |
| "Metformin is and has been considered as first-line therapy for type 2 diabetes for over a quarter of a century." | 1.43 | Should Restrictions Be Relaxed for Metformin Use in Chronic Kidney Disease? Yes, They Should Be Relaxed! What's the Fuss? ( Bakris, GL; Molitch, ME, 2016) |
| "Metformin is a first-line oral anti-hyperglycemic agent." | 1.42 | Metformin-related acidosis in a woman while performing Haj: a conservative approach. ( Althomaly, E; Alzayer, ZA; Ansari, RS; Mady, AF; Moulana, AA; Qutub, HO, 2015) |
| "The treatment of lactic acidosis is controversial, except for the imperative to remedy its underlying cause." | 1.42 | Lactic Acidosis in a Patient with Type 2 Diabetes Mellitus. ( Weisberg, LS, 2015) |
| "Metformin was often used in patients with contraindications, or in higher than recommended dosages in patients with renal impairment." | 1.42 | Metformin utilisation in Australian community and aged care settings. ( Castelino, RL; Huang, W; Peterson, GM; Zaidi, ST, 2015) |
| "Metformin is an oral antihyperglycemic agent used in the management of type 2 diabetes mellitus." | 1.40 | Fatal metformin overdose: case report and postmortem biochemistry contribution. ( Bonsignore, A; Fraternali Orcioni, G; Palmiere, C; Pozzi, F; Ventura, F, 2014) |
| "Metformin is a biguanide group oral antidiabetic drug used for the treatment of type 2 diabetes mellitus." | 1.40 | Lactic acidosis induced by metformin in a chronic hemodialysis patient with diabetes mellitus type 2. ( Altun, E; Karayaylalı, I; Kaya, B; Paydaş, S; Sarıakçalı, B, 2014) |
| "Patient 1: A 63-year-old man with type 2 diabetes mellitus presented to emergency department (ED) of Lodi (Italy) for dyspnea." | 1.40 | Acute metformin intoxication: 2012 experience of Emergency Departement of Lodi, Italy. ( Acquistapace, G; Canetta, C; Cosci, P; Garbi, M; Manelli, A; Ricevuti, G; Rossi, M, 2014) |
| "An 82-year-old woman with type 2 diabetes mellitus, hypertension, and unstable angina presented with severe lactic acidosis and acute kidney injury (AKI) accompanied by acute pancreatitis." | 1.39 | Severe lactic acidosis and acute pancreatitis associated with cimetidine in a patient with type 2 diabetes mellitus taking metformin. ( Ahn, KS; Hong, CW; Kang, GW; Lee, DY; Lee, IH; Seo, JH, 2013) |
| "Metformin-treated patients, especially elderly ones, are at a risk of sudden deterioration of renal function, which in turn may increase the risk of lactic acidosis." | 1.39 | Lactic acidosis in patients with diabetes. ( Karnafel, W; Krzymień, J, 2013) |
| "Metformin is a drug widely used in type 2 diabetic patients." | 1.38 | The importance of early haemodiafiltration in the treatment of lactic acidosis associated with the administration of metformin. ( Baró-Serra, A; Guasch-Aragay, B; Martín-Alemany, N; Sirvent, JM; Vallès-Prats, M, 2012) |
| "A metformin level was 150 μg/mL (therapeutic 1-2 μg/mL)." | 1.37 | Occult metformin toxicity in three patients with profound lactic acidosis. ( Gaieski, D; Perrone, J; Phillips, C, 2011) |
| "Metformin is a safe drug when correctly used in properly selected patients." | 1.37 | Metformin-induced lactic acidosis: no one left behind. ( Protti, A; Vecchio, S, 2011) |
| "Metformin is an antihyperglycemic agent commonly used in diabetic patients." | 1.37 | The nephrologist's role in metformin-induced lactic acidosis. ( Basterrechea, MA; de Arriba, G; Gómez-Navarro, L; Hernández-Sevillano, B; Pérez del Valle, KM; Rodríguez-Palomares, JR; Sánchez-Heras, M; Tallón, S; Torres-Guinea, M, 2011) |
| "Metformin is a widely used antidiabetic agent that is generally considered safe." | 1.37 | Metformin-associated lactic acidosis in Chinese patients with type II diabetes. ( Chan, WM; Chung, HY; Fong, BM; Siu, TS; Tam, S; Tsai, NW; Tsui, SH; Yeung, CW, 2011) |
| "Metformin is an oral antidiabetic agent, widely used in the treatment of type 2 diabetes mellitus." | 1.35 | Serum bicarbonate: can it be a marker of metformin induced acidosis in geriatrics? ( Adhikari, P; Pai, MR; Pathak, R; Pemminati, S; Rajeshwari, S; Rathnakar, UP, 2009) |
| "Lactic acidosis is a rare side effect of metformin." | 1.34 | [Metformin-related lactic acidosis in an 85-year-old woman]. ( Jansen, PA; Knol, W; van der Linden, CM; van Marum, RJ, 2007) |
| "Metformin is a biguanide used in the treatment of obese adults with type 2 diabetes mellitus; metformin decreases mortality by 36% in comparison to conventional treatment." | 1.34 | [Overdose of metformin secondary to acute renal insufficiency: a report of six cases]. ( Ambrós Checa, A; Gómez Grande, L; Martín Rodríguez, C; Ortega Carnicer, J; Portilla Botelho, M; Ruiz Lorenzo, F, 2007) |
| "Metformin, however, has the potential to increase serumlactate." | 1.33 | [Metformin-associated lactic acidosis in a patient with pre-existing risk factors]. ( Becker, C; Luginbühl, A; Pittl, U; Schlienger, R, 2005) |
| "A progressively deteriorating haemodynamic state led to an exploratory laparotomy." | 1.32 | [Lactic acidosis and acute abdomen from biguanide intoxication]. ( Barwing, J; Moerer, O; Neumann, P, 2004) |
| "Metformin is a biguanide commonly used in type 2 diabetes and considered to be a safe drug with minimal side effects." | 1.32 | Metformin induced acute pancreatitis precipitated by renal failure. ( Mallick, S, 2004) |
| " In the children younger than six years, dosage ranged from 9 to 196 mg/kg, with a mean and median of 60+/-41." | 1.31 | Multicenter case series of pediatric metformin ingestion. ( Gorman, SE; Hofman, M; Klein-Schwartz, W; Krenzelok, EP; Spiller, HA; Stork, CM; Weber, JA; Winter, ML, 2000) |
| "Metformin is an oral hypoglycemic agent belonging to the class of biguanides that are commonly used in the treatment of type II diabetes mellitus." | 1.31 | Metformin-associated lactic acidosis in a low risk patient. ( Ellis, AK; Iliescu, EA, 2001) |
| "No metformin related cases were found." | 1.28 | Biguanide related lactic acidosis: incidence and risk factors. ( Aguilar, C; García, JE; Reza, A; Rull, JA, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (1.70) | 18.7374 |
| 1990's | 68 (11.54) | 18.2507 |
| 2000's | 150 (25.47) | 29.6817 |
| 2010's | 263 (44.65) | 24.3611 |
| 2020's | 98 (16.64) | 2.80 |
| Authors | Studies |
|---|---|
| Tuncali, B | 1 |
| Temizkan Kırkayak, AG | 1 |
| Zeyneloğlu, P | 1 |
| Lagampan, C | 1 |
| Poovorawan, N | 1 |
| Parinyanitikul, N | 1 |
| Hayashi, A | 1 |
| Ishimura, T | 1 |
| Sugimoto, H | 1 |
| Suzuki, H | 1 |
| Hamasaki, A | 1 |
| Tsukamoto, T | 1 |
| Slahor, L | 2 |
| Vordoni, A | 1 |
| Theofilis, P | 1 |
| Vlachopanos, G | 1 |
| Koukoulaki, M | 1 |
| Kalaitzidis, RG | 1 |
| Reynolds, HV | 1 |
| Pollock, HHG | 1 |
| Apte, YV | 1 |
| Tabah, A | 1 |
| Shavadia, JS | 1 |
| Minhas, R | 1 |
| Orvold, J | 1 |
| Basran, R | 1 |
| Wells, C | 1 |
| DeVilliers, J | 1 |
| Pearce, C | 1 |
| Eckstein, J | 1 |
| Mangipudi, R | 1 |
| Haddad, H | 1 |
| Pollack, BE | 2 |
| Barbaro, RP | 2 |
| Selewski, DT | 2 |
| Carlton, EF | 2 |
| Tamaki, H | 1 |
| Tsushima, H | 1 |
| Kachi, N | 1 |
| Jimura, F | 1 |
| Theurey, P | 1 |
| Vial, G | 1 |
| Fontaine, E | 1 |
| Monternier, PA | 1 |
| Fouqueray, P | 1 |
| Bolze, S | 1 |
| Moller, DE | 1 |
| Hallakou-Bozec, S | 1 |
| Rueda Prada, L | 1 |
| Knopps, L | 1 |
| Dumic, I | 1 |
| Barusya, C | 1 |
| Subramanian, A | 1 |
| Charokopos, A | 1 |
| Zurob, AS | 1 |
| Chen, CC | 1 |
| Ko, Y | 1 |
| Chen, CH | 1 |
| Hung, YJ | 1 |
| Wei, TE | 1 |
| Chang, TH | 1 |
| Ke, SS | 1 |
| Kuo, KN | 1 |
| Chen, C | 1 |
| Mammadova, N | 1 |
| Soukup, J | 1 |
| Shkodivskyi, P | 1 |
| Gudowski, C | 1 |
| Ahmed, A | 1 |
| Pliquett, RU | 1 |
| Takayama, K | 1 |
| Obata, Y | 1 |
| Maruo, Y | 1 |
| Yamaguchi, H | 1 |
| Kosugi, M | 1 |
| Irie, Y | 1 |
| Hazama, Y | 1 |
| Yasuda, T | 1 |
| Balakrishnan, A | 1 |
| Sillanpää, M | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of Metformin Overdose in Adult Patients Treated at the University Hospital of Nancy: Single-center Descriptive Retrospective Observational Study[NCT04762966] | 50 participants (Anticipated) | Observational | 2021-03-01 | Recruiting | |||
| A Prospective, Randomized Open-Label Phase II Study of the Safety and Tolerability of Metformin in Combination With Standard Antimicrobial Treatment of Pulmonary Tuberculosis in People With TB and Co-infected With HIV[NCT04930744] | Phase 2 | 112 participants (Anticipated) | Interventional | 2021-08-03 | Recruiting | ||
| Metformin Use in Chronic Kidney Disease: The CKD-Met Study[NCT02844153] | 1,000 participants (Anticipated) | Observational | 2014-03-31 | Recruiting | |||
| Effect of the Administration of Melatonin and Metformin on Glycemic Control, Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes: Pilot Study[NCT03848533] | Phase 2 | 42 participants (Anticipated) | Interventional | 2019-08-22 | Recruiting | ||
| A Randomized, Crossover Study Assessing the Single Dose Pharmacokinetics of Delayed-Release Metformin in Subjects With Renal Dysfunction[NCT01658514] | Phase 2 | 39 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| Metformin as a Novel Treatment for Vitiligo by Targeting CD8+ T Cell Metabolism[NCT05607316] | Phase 2 | 30 participants (Anticipated) | Interventional | 2023-05-01 | Recruiting | ||
| Modulating Endoplasmic Reticulum Stress as a Prophylactic Approach Against Symptomatic Viral Infection[NCT04267809] | Phase 2 | 44 participants (Anticipated) | Interventional | 2021-10-22 | Recruiting | ||
| Incidence of Lactic Acidosis After Coronary Angiography and Angioplasty in Diabetic Patients on Continued Metformin Therapy With Normal Renal Function.[NCT01873859] | 166 participants (Actual) | Interventional | 2013-05-31 | Completed | |||
| Perioperative Continuation of Metformin Therapy in Patients With Typ 2 Diabetes Mellitus Undergoing Non-cardiac Surgery[NCT04284722] | Phase 4 | 400 participants (Anticipated) | Interventional | 2020-02-29 | Not yet recruiting | ||
| Metformin Continuation Versus Interruption Following Coronary Angiography: a Pilot Randomized Controlled Trial[NCT03980990] | Phase 4 | 500 participants (Anticipated) | Interventional | 2019-06-17 | Recruiting | ||
| A Randomized Trial of Metformin as Adjunct Therapy for Overweight Adolescents With Type 1 Diabetes[NCT01881828] | Phase 3 | 164 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| A Randomized Phase 3 Trial of Metformin in Patients Initiating Androgen Deprivation Therapy as Prevention and Intervention of Metabolic Syndrome: The Prime Study[NCT03031821] | Phase 3 | 168 participants (Actual) | Interventional | 2018-07-12 | Terminated (stopped due to Manufacturer discontinued the production of study drugs.) | ||
| Metformin Pharmacology in Human Cancers[NCT03477162] | Early Phase 1 | 18 participants (Actual) | Interventional | 2018-05-15 | Terminated (stopped due to Enrollment was closed as efforts had become more challenging, and the lab indicated that they were able to obtain their primary objective with the number that had already been enrolled.) | ||
| Use of Metformin in Prevention and Treatment of Cardiac Fibrosis in PAI-1 Deficient Population[NCT05317806] | Phase 4 | 15 participants (Anticipated) | Interventional | 2022-10-10 | Active, not recruiting | ||
| Metformin Continuation Safety in Diabetic Patients Undergoing Coronary Angiography[NCT04766008] | Phase 4 | 150 participants (Anticipated) | Interventional | 2020-01-15 | Recruiting | ||
| On the Role of Mitochondrial Dysfunction in the Pathogenesis of Metformin-associated Lactic Acidosis[NCT00942123] | 10 participants (Actual) | Observational | 2009-01-31 | Completed | |||
| Modulation of Insulin Secretion and Insulin Sensitivity in Bangladeshi Type 2 Diabetic Subjects by an Insulin Sensitizer Pioglitazone and T2DM Association With PPARG Gene Polymorphism.[NCT01589445] | Phase 4 | 77 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| Effect of Oral Combination Therapy of Metformin Extended Release Over Glimepiride in a Single Dosage Form in Patients With Type 2 Diabetes Mellitus With Failure of Monotherapy[NCT00941161] | Phase 4 | 28 participants (Anticipated) | Interventional | 2009-02-28 | Completed | ||
| Bioavailability of Glimepiride/Extended Release Metformin (4/850 mg) in Healthy Mexican Volunteers[NCT01437800] | Phase 1 | 24 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Bioavailability of Glimepiride/Extended Release Metformin (4/850 mg) After a High Fat Diet, in Healthy Mexican Volunteers[NCT01437813] | Phase 1 | 24 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
To determine the exposure-response relationship of metformin and plasma lactate concentrations (NCT01658514)
Timeframe: from the time of dosing (0 h) to 24 hours postdose
| Intervention | R² (Number) |
|---|---|
| Met DR | 0.000011129 |
| Met XR | 0.069527 |
AUC (0-t) = Area under the curve from the time of dosing (0 h) to the time of the last quantifiable concentration following dose administration (NCT01658514)
Timeframe: from the time of dosing (0 h) to 72 hours postdose
| Intervention | ng*h/mL (Least Squares Mean) | |||
|---|---|---|---|---|
| Normal (N = 8) | Mild RI (N = 10) | Moderate RI (N = 9) | Severe RI (N = 7) | |
| Met DR | 5362 | 8705 | 11477 | 22893 |
| Met XR | 10411 | 11788 | 20240 | 43683 |
Cmax = Maximum concentration from the time of dosing (0 h) to the time of the last quantifiable metformin concentration following dose administration (NCT01658514)
Timeframe: from the time of dosing (0 h) to 72 hours postdose
| Intervention | ng/mL (Least Squares Mean) | |||
|---|---|---|---|---|
| Normal (N = 8) | Mild RI (N = 10) | Moderate RI (N = 9) | Severe RI (N = 7) | |
| Met DR | 969 | 1036 | 925 | 1414 |
| Met XR | 1479 | 1340 | 1634 | 2590 |
(NCT01873859)
Timeframe: 48 hours from the baseline
| Intervention | mg/dl (Mean) |
|---|---|
| On-metformin | 1.05 |
| Off-metformin | 0.99 |
Metformin-associated lactic acidosis (MALA) was defined as an arterial pH <7.35 and plasma lactate concentration >5 mmol ⁄ L. (NCT01873859)
Timeframe: 48 hrs
| Intervention | participants (Number) |
|---|---|
| On-metformin | 0 |
| Off-metformin | 0 |
Change in percent body fat (NCT01881828)
Timeframe: 0-26 weeks
| Intervention | percentage of change (Mean) |
|---|---|
| Metformin | -0 |
| Oral Placebo | 1 |
(NCT01881828)
Timeframe: 0-26 weeks
| Intervention | percentile (Mean) |
|---|---|
| Metformin | -1 |
| Oral Placebo | 1 |
(NCT01881828)
Timeframe: 0-26 weeks
| Intervention | insulin per kg (Mean) |
|---|---|
| Metformin | -0.1 |
| Oral Placebo | -0.0 |
(NCT01881828)
Timeframe: 0-26 weeks
| Intervention | centimeters (Mean) |
|---|---|
| Metformin | -0 |
| Oral Placebo | 1 |
(NCT01881828)
Timeframe: 0-26 weeks
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Change in Systolic | Change in Diastolic | |
| Metformin | 0 | 0 |
| Oral Placebo | -0 | 0 |
Hemoglobin A1c is a measure of glycemic control over approximately the past 3 months (NCT01881828)
Timeframe: 0-26 weeks
| Intervention | percentage (Mean) | |
|---|---|---|
| HbA1c | Change from Baseline to 26 Weeks | |
| Metformin | 9.0 | 0.2 |
| Oral Placebo | 8.9 | 0.2 |
Hemoglobin A1c is a measure of glycemic control over approximately the past 3 months (NCT01881828)
Timeframe: 0-26 weeks
| Intervention | percentage of participants (Number) | ||
|---|---|---|---|
| HbA1c Decrease ≥0.5% | HbA1c Increase ≥0.5% | HbA1c <7.5% | |
| Metformin | 19 | 44 | 3 |
| Oral Placebo | 18 | 35 | 4 |
(NCT01881828)
Timeframe: 0-26 weeks
| Intervention | mg/dL (Mean) | ||||
|---|---|---|---|---|---|
| Change in LDL | Change in VLDL | Change in HDL | Change in Triglycerides | Change in Total Cholesterol | |
| Metformin | -6 | -0 | -0 | 4 | -5 |
| Oral Placebo | 2 | 1 | -1 | 6 | 3 |
To determine the concentration of metformin in adipose tissue. (NCT03477162)
Timeframe: Within 7 days from surgery
| Intervention | ng/g (Median) |
|---|---|
| Metformin | 70 |
To determine the concentration of metformin in plasma. (NCT03477162)
Timeframe: Within 7 days from surgery
| Intervention | ng/mL (Median) |
|---|---|
| Metformin | 450 |
To determine the concentration of metformin in tumor-adjacent normal tissue. (NCT03477162)
Timeframe: Within 7 days from surgery
| Intervention | ng/g (Median) |
|---|---|
| Metformin | 749 |
To determine the concentration of metformin in whole blood. (NCT03477162)
Timeframe: Within 7 days from surgery
| Intervention | ng/mL (Median) |
|---|---|
| Metformin | 514 |
To determine the intra-tumor concentrations of metformin, with a standard deviation ≤25% of the mean, in patients with solid tumors of thoracic origin administered metformin extended release. (NCT03477162)
Timeframe: Within 7 days from surgery
| Intervention | ng/g (Median) |
|---|---|
| Metformin | 1290 |
Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin. (NCT01589445)
Timeframe: 3 months for each drug
| Intervention | mmol/l (Mean) | |
|---|---|---|
| Baseline FSG | 3rd Month FSG | |
| Metformin ( 002 Group) | 6.2 | 6.5 |
| Pioglitazone (001 Group) | 6.9 | 5.4 |
Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin. (NCT01589445)
Timeframe: 3 months for each drug
| Intervention | μU/ml (Mean) | |
|---|---|---|
| Baseline FSI | 3rd month FSI | |
| Metformin ( 002 Group) | 13.0 | 13.9 |
| Pioglitazone (001 Group) | 16.2 | 12.3 |
Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin. (NCT01589445)
Timeframe: 3 months for each drug
| Intervention | percentage (Mean) | |
|---|---|---|
| Baseline HbA1c | 3rd month HbA1c | |
| Metformin ( 002 Group) | 7.8 | 7.0 |
| Pioglitazone (001 Group) | 7.3 | 6.7 |
"Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin.~Analysis 1: Homeostatic Model Assessment of Beta cell function(HOMA percent B) Analysis 2: Homeostatic Model Assessment of Insulin Sensitivity (Homa percent S)" (NCT01589445)
Timeframe: 3 months for each drug
| Intervention | percentage (Mean) | |||
|---|---|---|---|---|
| Baseline HOMA percent beta cells function | 3rd month HOMA percent beta cells function | Baseline HOMA percent sensitivity | 3rd month HOMA percent sensitivity | |
| Metformin ( 002 Group) | 109.3 | 116.0 | 76.2 | 67.2 |
| Pioglitazone (001 Group) | 118.9 | 132.3 | 51.1 | 69.3 |
"Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin.~Analysis 1: Homeostasis Model Assessment Insulin Resistance(HOMA IR) Analysis 2: Quantitative Insulin sensitivity Check Index(QUICKI)" (NCT01589445)
Timeframe: 3 months for each drug
| Intervention | Score on a scale ( SI unit) (Mean) | |||
|---|---|---|---|---|
| Baseline QUICKI | 3rd month QUICKI | Baseline HOMA IR | 3rd month HOMA IR | |
| Metformin ( 002 Group) | 0.57 | 0.54 | 3.7 | 4.3 |
| Pioglitazone (001 Group) | 0.52 | 0.59 | 5.1 | 2.9 |
"Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin.~Analysis 1:Total Cholesterol(TC) Analysis 2:Triglyceride(TG) Analysis 3:High Density Lipoprotein(HDL) Analysis 4:Low Density Lipoprotein(LDL)" (NCT01589445)
Timeframe: 3 months for each drug
| Intervention | mg/dl (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| Baseline TC | 3rd month TC | Baseline TG | 3rd month TG | Baseline HDL | 3rd month HDL | Baseline LDL | 3rd month LDL | |
| Metformin (002 Group) | 193.0 | 177.0 | 166.0 | 175.0 | 34.4 | 34.7 | 125.6 | 112.0 |
| Pioglitazone (001 Group) | 182.0 | 178 | 183 | 195 | 33 | 33.2 | 112.8 | 105.5 |
103 reviews available for metformin and Lactic Acidosis
| Article | Year |
|---|---|
Metformin as an emerging concern in wastewater: Occurrence, analysis and treatment methods.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Wastewater | 2022 |
Metformin: When Should We Fear Lactic Acidosis?
Topics: Acidosis, Lactic; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fear; Humans; Hypoglycemic Agents; M | 2022 |
Continuous extracorporeal clearance in metformin-associated lactic acidosis and metformin-induced lactic acidosis: a systematic review.
Topics: Acidosis, Lactic; Humans; Hypoglycemic Agents; Metformin; Prospective Studies; Retrospective Studies | 2022 |
Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Hypoglycemic Agents; La | 2022 |
Metformin's Role in Hyperlactatemia and Lactic Acidosis in ICU Patients: A Systematic Review.
Topics: Acidosis, Lactic; Creatinine; Humans; Hyperlactatemia; Hypoglycemic Agents; Intensive Care Units; La | 2023 |
Expanding the evidence for managing metformin poisoning to support decision-making.
Topics: Acidosis; Acidosis, Lactic; Drug Overdose; Humans; Hypoglycemic Agents; Metformin; Poisoning; Renal | 2023 |
[Acute Renal Failure, Lactic Acidosis, and Metformin: Two Case Reports and Literature Review].
Topics: Acidosis, Lactic; Acute Kidney Injury; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metfo | 2023 |
High risk and low prevalence diseases: Metformin toxicities.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Pr | 2023 |
Extracorporeal removal techniques in toxicology: part 2.
Topics: Acidosis, Lactic; Drug Overdose; Humans; Hypoglycemic Agents; Metformin; Renal Dialysis; Theophyllin | 2019 |
Metformin lactic acidosis: Should we still be afraid?
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin | 2019 |
Do Patients Die with or from Metformin-Associated Lactic Acidosis (MALA)? Systematic Review and Meta-analysis of pH and Lactate as Predictors of Mortality in MALA.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Aged; Biomarkers; Female; Humans; Hydrogen-Ion Concentratio | 2020 |
A review of phenformin, metformin, and imeglimin.
Topics: Acidosis, Lactic; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Me | 2020 |
Metformin: the updated protective property in kidney disease.
Topics: Acidosis, Lactic; Acute Kidney Injury; AMP-Activated Protein Kinases; Animals; Disease Models, Anima | 2020 |
COVID-19 in diabetic patients: Related risks and specifics of management.
Topics: Acidosis, Lactic; Betacoronavirus; Comorbidity; Coronavirus Infections; COVID-19; Critical Illness; | 2020 |
Etiology and Management of Acute Metabolic Acidosis: An Update.
Topics: Acidosis; Acidosis, Lactic; Acute Disease; Animals; Bicarbonates; Disease Management; Electrolytes; | 2020 |
Osmolar-gap in the setting of metformin-associated lactic acidosis: Case report and a literature review highlighting an apparently unusual association.
Topics: Acid-Base Imbalance; Acidosis, Lactic; Acute Kidney Injury; Diabetes Mellitus, Type 2; Humans; Hypog | 2020 |
Metformin, chronic nephropathy and lactic acidosis: a multi-faceted issue for the nephrologist.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Kidney Failure, Chronic; M | 2021 |
[Metformin Therapy During Surgical Interventions and Iodinated Contrast Agent Use].
Topics: Acidosis, Lactic; Contrast Media; Diabetes Mellitus, Type 2; Glomerular Filtration Rate; Humans; Hyp | 2021 |
Metformin Benefits: Another Example for Alternative Energy Substrate Mechanism?
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Prospective Stu | 2021 |
Mechanism and application of metformin in kidney diseases: An update.
Topics: Acidosis, Lactic; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Type 2; Diabetic Nephro | 2021 |
Metformin-associated lactic acidosis (MALA): Moving towards a new paradigm.
Topics: Acidosis, Lactic; Animals; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Risk F | 2017 |
Serum lactate level and mortality in metformin-associated lactic acidosis requiring renal replacement therapy: a systematic review of case reports and case series.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Biomarkers; Female; Humans; Hypoglycemic Agents; | 2017 |
Lactate Levels with Chronic Metformin Use: A Narrative Review.
Topics: Acidosis, Lactic; Humans; Hypoglycemic Agents; Incidence; Lactic Acid; Metformin; Renal Insufficienc | 2017 |
Still sour about lactic acidosis years later: role of metformin in heart failure.
Topics: Acidosis, Lactic; Blood Glucose; Diabetes Mellitus, Type 2; Global Health; Heart Failure; Humans; Hy | 2018 |
[Metformin-associated lactic acidosis: an insufficiently recognised problem].
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic A | 2017 |
Metformin: A Candidate Drug for Renal Diseases.
Topics: Acidosis, Lactic; Acute Kidney Injury; AMP-Activated Protein Kinases; Animals; Clinical Trials as To | 2018 |
SGLT2 inhibitors and metformin: Dual antihyperglycemic therapy and the risk of metabolic acidosis in type 2 diabetes.
Topics: Acidosis, Lactic; Benzhydryl Compounds; Canagliflozin; Diabetes Mellitus, Type 2; Diabetic Ketoacido | 2019 |
The Association between Metformin Therapy and Lactic Acidosis.
Topics: Acidosis, Lactic; Causality; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Rena | 2019 |
Metformin-associated lactic acidosis requiring hospitalization. A national 10 year survey and a systematic literature review.
Topics: Acidosis, Lactic; Adverse Drug Reaction Reporting Systems; Aged; Female; Health Surveys; Hospitaliza | 2013 |
Unleash metformin: reconsideration of the contraindication in patients with renal impairment.
Topics: Acidosis, Lactic; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Kidney | 2013 |
Metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Male; Metformin; Mid | 2015 |
Systematic reviews to ascertain the safety of diabetes medications.
Topics: Acidosis, Lactic; Blood Glucose; Diabetes Mellitus, Type 2; Evidence-Based Medicine; Female; Fractur | 2014 |
Metformin and other antidiabetic agents in renal failure patients.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dipeptidyl-Peptidase IV Inhibit | 2015 |
Metformin in chronic kidney disease: time for a rethink.
Topics: Acidosis, Lactic; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metform | 2014 |
A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure.
Topics: Acidosis, Lactic; Diabetes Mellitus; Drug Administration Schedule; Drug Overdose; Glomerular Filtrat | 2014 |
Mortality rate in so-called "metformin-associated lactic acidosis": a review of the data since the 1960s.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Humans; Hydrogen-Ion | 2014 |
Metformin-associated lactic acidosis in a peritoneal dialysis patient.
Topics: Acidosis, Lactic; Aged, 80 and over; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Hypo | 2015 |
[Metformin is also recommended in mild and moderate renal failure].
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Hypoglycemic Agents; Ki | 2015 |
Extracorporeal Treatment for Metformin Poisoning: Systematic Review and Recommendations From the Extracorporeal Treatments in Poisoning Workgroup.
Topics: Acidosis, Lactic; Consciousness; Delphi Technique; Humans; Hydrogen-Ion Concentration; Lactic Acid; | 2015 |
Metformin-associated lactic acidosis: Current perspectives on causes and risk.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Risk Factors | 2016 |
Metformin-associated lactic acidosis: Current perspectives on causes and risk.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Risk Factors | 2016 |
Metformin-associated lactic acidosis: Current perspectives on causes and risk.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Risk Factors | 2016 |
Metformin-associated lactic acidosis: Current perspectives on causes and risk.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Risk Factors | 2016 |
Metformin-associated lactic acidosis: Current perspectives on causes and risk.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Risk Factors | 2016 |
Metformin-associated lactic acidosis: Current perspectives on causes and risk.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Risk Factors | 2016 |
Metformin-associated lactic acidosis: Current perspectives on causes and risk.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Risk Factors | 2016 |
Metformin-associated lactic acidosis: Current perspectives on causes and risk.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Risk Factors | 2016 |
Metformin-associated lactic acidosis: Current perspectives on causes and risk.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Risk Factors | 2016 |
Metformin associated lactic acidosis (MALA): clinical profiling and management.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Aged; Aged, 80 and over; Diabetes Mellitus; Diabetic Nephro | 2016 |
Metformin-related lactic acidosis: is it a myth or an underestimated reality?
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Renal Insuffici | 2016 |
Could metformin be used in patients with diabetes and advanced chronic kidney disease?
Topics: Acidosis, Lactic; Comorbidity; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Hypoglycem | 2017 |
Topics: Acidosis, Lactic; Drug Administration Schedule; Evidence-Based Medicine; Humans; Hypoglycemic Agents | 2017 |
[Metformin and kidneys].
Topics: Acidosis, Lactic; Animals; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents | 2008 |
Should dialysis be offered in all cases of metformin-associated lactic acidosis?
Topics: Acidosis, Lactic; Animals; Humans; Metformin; Renal Dialysis | 2009 |
Acute metformin overdose: examining serum pH, lactate level, and metformin concentrations in survivors versus nonsurvivors: a systematic review of the literature.
Topics: Acidosis, Lactic; Acute Disease; Adult; Drug Overdose; Female; Humans; Hydrogen-Ion Concentration; H | 2009 |
Metformin: safety in cardiac patients.
Topics: Acidosis, Lactic; Contraindications; Contrast Media; Heart Failure; Humans; Hypoglycemic Agents; Iod | 2010 |
Systematic review of current guidelines, and their evidence base, on risk of lactic acidosis after administration of contrast medium for patients receiving metformin.
Topics: Acidosis, Lactic; Contrast Media; Drug Interactions; Evidence-Based Medicine; Humans; Hypoglycemic A | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2010 |
Metformin: safety in cardiac patients.
Topics: Acidosis, Lactic; Diabetes Mellitus; Diabetic Angiopathies; Heart Failure; Humans; Hypoglycemic Agen | 2010 |
Review: metformin: potential benefits and use in chronic kidney disease.
Topics: Acidosis, Lactic; Blood Glucose; Chronic Disease; Diabetes Mellitus, Type 2; Diabetic Nephropathies; | 2010 |
The role of serum lactate in the acute care setting.
Topics: Acidosis, Lactic; Adult; Aged; Antiretroviral Therapy, Highly Active; Biomarkers; Critical Care; Dru | 2010 |
Lactic acidosis induced by metformin: incidence, management and prevention.
Topics: Acidosis, Lactic; Animals; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Incidence; Metfor | 2010 |
Lactic acidosis induced by metformin: incidence, management and prevention.
Topics: Acidosis, Lactic; Animals; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Incidence; Metfor | 2010 |
Lactic acidosis induced by metformin: incidence, management and prevention.
Topics: Acidosis, Lactic; Animals; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Incidence; Metfor | 2010 |
Lactic acidosis induced by metformin: incidence, management and prevention.
Topics: Acidosis, Lactic; Animals; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Incidence; Metfor | 2010 |
Metformin: the safest hypoglycaemic agent in chronic kidney disease?
Topics: Acidosis, Lactic; Animals; Humans; Hypoglycemic Agents; Kidney Failure, Chronic; Metformin | 2011 |
Perioperative use of metformin in cardiac surgery.
Topics: Acidosis, Lactic; Humans; Hypoglycemic Agents; Metformin; Perioperative Period; Thoracic Surgery | 2010 |
Use of metformin in the setting of mild-to-moderate renal insufficiency.
Topics: Acidosis, Lactic; Contraindications; Creatinine; Diabetes Mellitus, Type 2; Female; Glomerular Filtr | 2011 |
Use of metformin in the setting of mild-to-moderate renal insufficiency.
Topics: Acidosis, Lactic; Contraindications; Creatinine; Diabetes Mellitus, Type 2; Female; Glomerular Filtr | 2011 |
Use of metformin in the setting of mild-to-moderate renal insufficiency.
Topics: Acidosis, Lactic; Contraindications; Creatinine; Diabetes Mellitus, Type 2; Female; Glomerular Filtr | 2011 |
Use of metformin in the setting of mild-to-moderate renal insufficiency.
Topics: Acidosis, Lactic; Contraindications; Creatinine; Diabetes Mellitus, Type 2; Female; Glomerular Filtr | 2011 |
Use of metformin in the setting of mild-to-moderate renal insufficiency.
Topics: Acidosis, Lactic; Contraindications; Creatinine; Diabetes Mellitus, Type 2; Female; Glomerular Filtr | 2011 |
Use of metformin in the setting of mild-to-moderate renal insufficiency.
Topics: Acidosis, Lactic; Contraindications; Creatinine; Diabetes Mellitus, Type 2; Female; Glomerular Filtr | 2011 |
Use of metformin in the setting of mild-to-moderate renal insufficiency.
Topics: Acidosis, Lactic; Contraindications; Creatinine; Diabetes Mellitus, Type 2; Female; Glomerular Filtr | 2011 |
Use of metformin in the setting of mild-to-moderate renal insufficiency.
Topics: Acidosis, Lactic; Contraindications; Creatinine; Diabetes Mellitus, Type 2; Female; Glomerular Filtr | 2011 |
Use of metformin in the setting of mild-to-moderate renal insufficiency.
Topics: Acidosis, Lactic; Contraindications; Creatinine; Diabetes Mellitus, Type 2; Female; Glomerular Filtr | 2011 |
Discontinuation of metformin in the setting of coronary angiography: clinical uncertainty amongst physicians reflecting a poor evidence base.
Topics: Acidosis, Lactic; Angioplasty, Balloon, Coronary; Contraindications; Coronary Angiography; Data Coll | 2012 |
Discontinuation of metformin in the setting of coronary angiography: clinical uncertainty amongst physicians reflecting a poor evidence base.
Topics: Acidosis, Lactic; Angioplasty, Balloon, Coronary; Contraindications; Coronary Angiography; Data Coll | 2012 |
Discontinuation of metformin in the setting of coronary angiography: clinical uncertainty amongst physicians reflecting a poor evidence base.
Topics: Acidosis, Lactic; Angioplasty, Balloon, Coronary; Contraindications; Coronary Angiography; Data Coll | 2012 |
Discontinuation of metformin in the setting of coronary angiography: clinical uncertainty amongst physicians reflecting a poor evidence base.
Topics: Acidosis, Lactic; Angioplasty, Balloon, Coronary; Contraindications; Coronary Angiography; Data Coll | 2012 |
[Metformin and insulin in chronic heart failure: contraindications not contraindicated and indications not indicated].
Topics: Acidosis, Lactic; Cardiovascular Agents; Clinical Trials as Topic; Contraindications; Diabetes Melli | 2011 |
Iodine-based radiographic contrast medium may precipitate metformin-associated lactic acidosis in diabetic patients. A case report, literature review and practical approach.
Topics: Acidosis, Lactic; Aged, 80 and over; Atrial Fibrillation; Contraindications; Contrast Media; Creatin | 2012 |
[Metformin associates lactic acidosis].
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Female; Humans; Hypoglycemic Agents; Male; Metformin; Mid | 2012 |
[Proposal for the modification of metformin use in patients with chronic kidney disease].
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination | 2012 |
Metformin-associated lactic acidosis (MALA): case files of the Einstein Medical Center medical toxicology fellowship.
Topics: Acidosis, Lactic; Adult; Drug Overdose; Humans; Hypoglycemic Agents; Male; Metformin; Renal Dialysis | 2013 |
Oral hypoglycaemics. When not to use what.
Topics: Acarbose; Acidosis, Lactic; Aged; Contraindications; Diabetes Mellitus, Type 2; Female; Glyburide; H | 2002 |
[Adverse effect of biguanides].
Topics: Acidosis, Lactic; Biguanides; Diabetes Mellitus, Type 2; Gastrointestinal Diseases; Humans; Hypoglyc | 2002 |
[Perioperative metformin and lactacidosis].
Topics: Acidosis, Lactic; Anesthesia; Animals; Diabetes Complications; Humans; Hypoglycemic Agents; Intraope | 2002 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2003 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Phenformin; Ris | 2003 |
Metformin and lactic acidosis: cause or coincidence? A review of case reports.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; Humans; Hypogly | 2004 |
The phantom of lactic acidosis due to metformin in patients with diabetes.
Topics: Acidosis, Lactic; Diabetes Mellitus; Humans; Hypoglycemic Agents; Metformin | 2004 |
[Progress in diagnosis of and therapy for diabetic lactic acidosis].
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Blood Gas Analysis; Consciousness Disorders; Diabetes Compl | 2004 |
Link between metformin and lactic acidosis?
Topics: Acidosis, Lactic; Evidence-Based Medicine; Humans; Hypoglycemic Agents; Metformin | 2004 |
Metformin's contraindications should be contraindicated.
Topics: Acidosis, Lactic; Age Factors; Aged; Aged, 80 and over; Contraindications; Diabetes Mellitus, Type 2 | 2005 |
Metformin lactic acidosis and anaesthesia: myth or reality?
Topics: Acidosis, Lactic; Anesthesia; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin | 2005 |
[Traditional contraindications to the use of metformin -- more harmful than beneficial?].
Topics: Acidosis, Lactic; Age Factors; Contraindications; Diabetes Mellitus, Type 2; Drug Interactions; Hear | 2006 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2006 |
Adverse reactions to intravenous iodinated contrast media: a primer for radiologists.
Topics: Acidosis, Lactic; Contrast Media; Drug Hypersensitivity; Humans; Incidence; Injections, Intravenous; | 2006 |
[Metformin-associated lactic acidosis].
Topics: Acidosis, Lactic; Biguanides; Humans; Hypoglycemic Agents; Metformin | 2006 |
The safety of metformin in heart failure.
Topics: Acidosis, Lactic; Aged; Clinical Trials as Topic; Contraindications; Female; Health Status; Heart Fa | 2007 |
Metformin, heart failure, and lactic acidosis: is metformin absolutely contraindicated?
Topics: Acidosis, Lactic; Contraindications; Diabetes Mellitus, Type 2; Heart Failure; Humans; Hypoglycemic | 2007 |
Metformin: effective and safe in renal disease?
Topics: Acidosis, Lactic; Animals; Contraindications; Creatinine; Diabetes Mellitus, Type 2; Diabetic Angiop | 2008 |
Reality of severe metformin-induced lactic acidosis in the absence of chronic renal impairment.
Topics: Acidosis, Lactic; Aged; Bicarbonates; Female; Humans; Hypoglycemic Agents; Kidney Failure, Chronic; | 2008 |
Metformin and intestinal glucose handling.
Topics: Acidosis, Lactic; Animals; Diabetes Mellitus, Type 2; Glucose; Humans; Hypoglycemic Agents; Intestin | 1995 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypoglycemic Agents; | 1996 |
Metformin: a safe and effective treatment in the management of NIDDM.
Topics: Acidosis, Lactic; Blood Glucose; Diabetes Mellitus, Type 2; Drug Tolerance; Humans; Hypoglycemic Age | 1997 |
Metformin.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; Hypoglycemic Agents; Met | 1997 |
Metformin and contrast media--a dangerous combination?
Topics: Acidosis, Lactic; Algorithms; Contraindications; Contrast Media; Diabetes Mellitus, Type 2; Drug Int | 1999 |
Metformin-associated lactic acidosis: a rare or very rare clinical entity?
Topics: Acidosis, Lactic; Administration, Oral; Diabetes Mellitus, Type 2; England; Humans; Hypoglycemic Age | 1999 |
A risk-benefit assessment of metformin in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Body Weight; Contraindications; Diabetes Mellitus, Type 2; Female; Glucose; Humans | 1999 |
[Metformin-induced lactic acidosis].
Topics: Acidosis, Lactic; Acute Disease; Coma; Combined Modality Therapy; Contraindications; Diabetes Mellit | 2000 |
[Metformin associated lactic acidosis--case reports and literature review].
Topics: Acidosis, Lactic; Aged; Contraindications; Fatal Outcome; Female; Humans; Hypoglycemic Agents; Metfo | 2000 |
[Metformin efficacious in poorly controlled diabetes mellitus type 2].
Topics: Abdominal Pain; Acidosis, Lactic; Aged; Blood Glucose; Contraindications; Diabetes Mellitus; Diabete | 2000 |
[Current role of metformin in treatment of diabetes mellitus type 2].
Topics: Acidosis, Lactic; Contraindications; Diabetes Mellitus; Diabetes Mellitus, Type 2; Humans; Hypoglyce | 2000 |
[Prevention of lactic acidosis due to metformin intoxication in contrast media nephropathy].
Topics: Acidosis, Lactic; Clinical Protocols; Contraindications; Contrast Media; Creatinine; Diabetes Mellit | 2000 |
Metformin and lactic acidosis in diabetic humans.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Humans; Hypoglycemic Agents; Met | 2000 |
[Should the occurrence of a first coronary event change the management of diabetes?].
Topics: Acidosis, Lactic; Acute Disease; Adrenergic beta-Antagonists; Blood Glucose; Cardiovascular Agents; | 2000 |
Lactic acidosis in metformin therapy: searching for a link with metformin in reports of 'metformin-associated lactic acidosis'.
Topics: Acidosis, Lactic; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Humans; H | 2001 |
Adverse reactions to iodinated contrast media.
Topics: Acidosis, Lactic; Contrast Media; Drug Hypersensitivity; Humans; Hypoglycemic Agents; Injections; Io | 2001 |
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Cohort Studies; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2002 |
Biguanide-associated lactic acidosis. Case report and review of the literature.
Topics: Acidosis, Lactic; Biguanides; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Emigration and Immi | 1992 |
[Management and treatment of lactic acidosis].
Topics: Acidosis, Lactic; Bicarbonates; Diabetes Complications; Diabetes Mellitus; Humans; Metformin; Renal | 1990 |
[Biguanides in the treatment of diabetes mellitus].
Topics: Acidosis, Lactic; Biguanides; Diabetes Mellitus; Humans; Lipid Metabolism; Metformin | 1989 |
8 trials available for metformin and Lactic Acidosis
| Article | Year |
|---|---|
Safety of metformin continuation in diabetic patients undergoing invasive coronary angiography: the NO-STOP single arm trial.
Topics: Acidosis, Lactic; Acute Kidney Injury; Coronary Angiography; Diabetes Mellitus; Humans; Hypoglycemic | 2023 |
Metformin-Associated Lactic Acidosis Undergoing Renal Replacement Therapy in Intensive Care Units: A Five-Million Population-Based Study in the North-West of Italy.
Topics: Acidosis, Lactic; Aged; Critical Care; Female; Humans; Intensive Care Units; Italy; Male; Metformin; | 2017 |
A case risk study of lactic acidosis risk by metformin use in type 2 diabetes mellitus tuberculosis coinfection patients.
Topics: Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Lactic Acid | 2018 |
Is it necessary to discontinue metformin in diabetic patients with GFR > 60 ml/min per 1.73 m2 undergoing coronary angiography: A controversy still exists?
Topics: Acidosis, Lactic; Contrast Media; Coronary Angiography; Diabetes Mellitus; Drug Administration Sched | 2018 |
Monitoring metformin in cardiac patients exposed to contrast media using ultra-high-performance liquid chromatography tandem mass-spectrometry.
Topics: Acidosis, Lactic; Cardiac Catheterization; Chromatography, High Pressure Liquid; Contrast Media; Cre | 2011 |
Comparative outcomes study of metformin intervention versus conventional approach the COSMIC Approach Study.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Metfor | 2005 |
Rosiglitazone does not alter the pharmacokinetics of metformin.
Topics: Acidosis, Lactic; Adult; Cross-Over Studies; Drug Interactions; Drug Therapy, Combination; Humans; H | 2000 |
The hyperlactatemic effect of biguanides: a comparison between phenformin and metformin during a 6-month treatment.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Female; Humans; Male; Metformin; Middle Aged; Phenformi | 1989 |
478 other studies available for metformin and Lactic Acidosis
| Article | Year |
|---|---|
Continuous veno-venous hemodiafiltration in metformin-associated lactic acidosis caused by a suicide attempt: A report of two cases.
Topics: Acidosis, Lactic; Continuous Renal Replacement Therapy; Diabetes Mellitus, Type 2; Humans; Hypoglyce | 2021 |
Lactic acidosis, a potential toxicity from drug-drug interaction related to concomitant ribociclib and metformin in preexisting renal insufficiency: A case report.
Topics: Acidosis, Lactic; Aminopyridines; Breast Neoplasms; Drug Interactions; Female; Fulvestrant; Humans; | 2022 |
Metformin-associated lactic acidosis exacerbated by acute kidney injury in an overseas traveler.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Angiotensin-Converting Enzyme Inhibitors; Diuretics; Fe | 2022 |
[CME: Metformin - Dos and Don'ts].
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Renal Insuffici | 2021 |
Metformin-associated lactic acidosis and acute kidney injury in the era of COVID-19.
Topics: Acidosis, Lactic; Acute Kidney Injury; COVID-19; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Age | 2021 |
[CME/Answers: Metformin - Dos and Don'ts].
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Renal Insuffici | 2022 |
Achieving High Dialysis Dose via Continuous Renal Replacement Therapy in the Setting of Metformin Associated Lactic Acidosis. A Case Series.
Topics: Acidosis, Lactic; Continuous Renal Replacement Therapy; Humans; Hypoglycemic Agents; Metformin; Rena | 2022 |
Randomized Comparison of Metformin Continuation Versus Interruption Following Coronary Angiography/Angioplasty: Contemporary Risk for Lactic Acidosis.
Topics: Acidosis, Lactic; Angioplasty; Coronary Angiography; Humans; Metformin; Treatment Outcome | 2022 |
Lactic acidosis and multisystem organ failure following ibuprofen overdose requiring haemodialysis.
Topics: Acidosis, Lactic; Adolescent; Child; Continuous Renal Replacement Therapy; Drug Overdose; Humans; Ib | 2022 |
Cardiac Dysfunction Due to Thiamine Deficiency after Hemodialysis for Biguanide-related Lactic Acidosis.
Topics: Acidosis, Lactic; Beriberi; Biguanides; Diabetes Mellitus, Type 2; Heart Diseases; Humans; Hypoglyce | 2022 |
Reduced lactic acidosis risk with Imeglimin: Comparison with Metformin.
Topics: Acidosis, Lactic; Animals; Diabetes Mellitus, Type 2; Dogs; Humans; Hypoglycemic Agents; Lactic Acid | 2022 |
Transient Complete Blindness Due to Metformin-Associated Lactic Acidosis (MALA) Reversed with Hemodialysis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Blindness; Diabetes Mellitus, Type 2; Diarrhea; Female; | 2022 |
Relationship between metformin use and lactic acidosis in advanced chronic kidney disease: The REMIND-TMU study.
Topics: Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Renal In | 2022 |
A patient with severe metformin-associated lactic acidosis complicated by acute coronary syndrome: a case report.
Topics: Acidosis, Lactic; Acute Coronary Syndrome; Acute Kidney Injury; Bicarbonates; Diabetes Mellitus, Typ | 2022 |
Metformin-associated Lactic Acidosis with Hypoglycemia during the COVID-19 Pandemic.
Topics: Acidosis, Lactic; COVID-19; Diabetes Mellitus, Type 2; Humans; Hypoglycemia; Hypoglycemic Agents; Ma | 2022 |
Clinical presentations and prognosis of metformin-associated lactic acidosis patients in the intensive care unit: A 20-year survey.
Topics: Acidosis, Lactic; Adult; Humans; Intensive Care Units; Metformin; Prognosis; Retrospective Studies | 2022 |
Relationship Between Plasmatic Metformin Concentration and Renal Replacement Therapy: A Multicenter Cohort Study.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Cohort Studies; Diabetes Mellitus, Type 2; Humans; | 2022 |
Metformin-associated lactic acidosis and factors associated with 30-day mortality.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Renal Dialysis | 2022 |
Unusual Case of Metformin-Associated Lactic Acidosis in Patient with Type 2 Diabetes Mellitus.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Humans; Male; Metformin; Renal Dialysis; Renal In | 2022 |
Unusual Case of Metformin-Associated Lactic Acidosis in Patient with Type 2 Diabetes Mellitus.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Humans; Male; Metformin; Renal Dialysis; Renal In | 2022 |
Unusual Case of Metformin-Associated Lactic Acidosis in Patient with Type 2 Diabetes Mellitus.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Humans; Male; Metformin; Renal Dialysis; Renal In | 2022 |
Unusual Case of Metformin-Associated Lactic Acidosis in Patient with Type 2 Diabetes Mellitus.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Humans; Male; Metformin; Renal Dialysis; Renal In | 2022 |
Unusual Case of Metformin-Associated Lactic Acidosis in Patient with Type 2 Diabetes Mellitus.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Humans; Male; Metformin; Renal Dialysis; Renal In | 2022 |
Unusual Case of Metformin-Associated Lactic Acidosis in Patient with Type 2 Diabetes Mellitus.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Humans; Male; Metformin; Renal Dialysis; Renal In | 2022 |
Unusual Case of Metformin-Associated Lactic Acidosis in Patient with Type 2 Diabetes Mellitus.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Humans; Male; Metformin; Renal Dialysis; Renal In | 2022 |
Unusual Case of Metformin-Associated Lactic Acidosis in Patient with Type 2 Diabetes Mellitus.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Humans; Male; Metformin; Renal Dialysis; Renal In | 2022 |
Unusual Case of Metformin-Associated Lactic Acidosis in Patient with Type 2 Diabetes Mellitus.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Humans; Male; Metformin; Renal Dialysis; Renal In | 2022 |
[Cross-Sectional Study on Adverse Effects of Metformin Hydrochloride on 130 Patients Type 2 Diabetic Admitted to Medical Center and Diabetes Home of Sidi Bel-Abbès].
Topics: Acidosis, Lactic; Adult; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Drug-Related Side Effec | 2023 |
[Cross-Sectional Study on Adverse Effects of Metformin Hydrochloride on 130 Patients Type 2 Diabetic Admitted to Medical Center and Diabetes Home of Sidi Bel-Abbès].
Topics: Acidosis, Lactic; Adult; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Drug-Related Side Effec | 2023 |
[Cross-Sectional Study on Adverse Effects of Metformin Hydrochloride on 130 Patients Type 2 Diabetic Admitted to Medical Center and Diabetes Home of Sidi Bel-Abbès].
Topics: Acidosis, Lactic; Adult; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Drug-Related Side Effec | 2023 |
[Cross-Sectional Study on Adverse Effects of Metformin Hydrochloride on 130 Patients Type 2 Diabetic Admitted to Medical Center and Diabetes Home of Sidi Bel-Abbès].
Topics: Acidosis, Lactic; Adult; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Drug-Related Side Effec | 2023 |
Metformin-associated severe lactic acidosis combined with multi-organ insufficiency induced by infection with Aeromonas veronii: A case report.
Topics: Acidosis, Lactic; Aeromonas veronii; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic A | 2023 |
Lactic acidosis and multisystem organ failure following ibuprofen overdose requiring haemodialysis.
Topics: Acidosis, Lactic; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Hypoglycem | 2023 |
Simultaneous, dual continuous veno-venous haemofiltration for refractory metformin-induced lactic acidosis: a case report.
Topics: Acidosis, Lactic; Continuous Renal Replacement Therapy; Diabetes Mellitus, Type 2; Humans; Hypoglyce | 2023 |
[Metformin-associated lactic acidosis].
Topics: Acidosis, Lactic; Aged; Bradycardia; Female; Humans; Hypoglycemic Agents; Hypotension; Metformin; Me | 2023 |
Toxicokinetics of metformin overdose treated with CVVHDF.
Topics: Acidosis, Lactic; Continuous Renal Replacement Therapy; Drug Overdose; Hemodiafiltration; Humans; Hy | 2023 |
Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes diagnosed after metformin-triggered stroke-like episodes.
Topics: Acidosis, Lactic; Adult; Hearing Loss, Sensorineural; Humans; Male; MELAS Syndrome; Metformin; Strok | 2023 |
Severe lactic acidosis with euglycemic diabetic ketoacidosis due to metformin overdose.
Topics: Acidosis; Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Female; Humans; Ketone | 2023 |
Metformin Use and Long-term Clinical Outcomes in Kidney Transplant Recipients.
Topics: Acidosis, Lactic; Diabetes Mellitus; Humans; Kidney Transplantation; Metformin; Retrospective Studie | 2023 |
Risk of Lactic Acidosis in Hospitalized Diabetic Patients Prescribed Biguanides in Japan: A Retrospective Total-Population Cohort Study.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Biguanides; Cohort Studies; Diabetes Mellitus; Female; Hu | 2023 |
Letter to the Editor regarding "Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes diagnosed after metformin-triggered stroke-like episodes".
Topics: Acidosis, Lactic; Humans; Metformin; Mitochondrial Encephalomyopathies; Stroke | 2023 |
In reply to the letter to the editor reading: Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes diagnosed after metformin-triggered stroke-like episodes.
Topics: Acidosis, Lactic; Humans; Metformin; Reading; Stroke | 2023 |
Metformin-associated lactic acidosis reported to the United Kingdom National Poisons Information Service (NPIS) between 2010 and 2019: a ten-year retrospective analysis.
Topics: Acidosis, Lactic; Drug Overdose; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Poisons; Retro | 2023 |
Effects of plateau hypoxia on population pharmacokinetics and pharmacodynamics of metformin in patients with Type 2 diabetes.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Glucose; Humans; Hypoxia; Metformin; Tandem Mass Spectr | 2023 |
The elimination half-life of metformin during metformin overdose.
Topics: Acidosis, Lactic; Drug Overdose; Half-Life; Hemodiafiltration; Humans; Hypoglycemic Agents; Metformi | 2023 |
Surviving cardiac arrest from severe metformin-associated lactic acidosis using extracorporeal membrane oxygenation and double continuous venovenous haemodialysis.
Topics: Acidosis, Lactic; Continuous Renal Replacement Therapy; Extracorporeal Membrane Oxygenation; Heart A | 2023 |
Daily dose of metformin caused acute kidney injury with lactic acidosis: a case report.
Topics: Acidosis, Lactic; Acute Kidney Injury; Creatinine; Diabetes Mellitus, Type 2; Humans; Kidney Tubular | 2023 |
Treatment of severe metformin-associated lactic acidosis with renal replacement therapy and tris-hydroxymethyl aminomethane: a case report.
Topics: Acidosis, Lactic; Adult; Carbon Dioxide; Continuous Renal Replacement Therapy; Humans; Hypoglycemic | 2023 |
Reversible acute blindness in suspected metformin-associated lactic acidosis: a case report.
Topics: Acidosis; Acidosis, Lactic; Acute Kidney Injury; Blindness; Diabetes Mellitus, Type 2; Female; Human | 2023 |
Reversible Acute Blindness in Suspected Metformin-Associated Lactic Acidosis.
Topics: Acidosis, Lactic; Aged; Blindness; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Male; Met | 2019 |
Reports of Lactic Acidosis Attributed to Metformin, 2015-2018.
Topics: Acidosis, Lactic; Adult; Adverse Drug Reaction Reporting Systems; Aged; Diabetic Nephropathies; Fema | 2020 |
Metformin-associated lactic acidosis: A case reporting a serious complication in the perioperative period.
Topics: Acidosis, Lactic; Aged; Anuria; Diabetes Mellitus, Type 2; Female; Heart Arrest; Humans; Hypoglycemi | 2019 |
Laboratory-Confirmed Metformin-Associated Lactic Acidosis
Topics: Acidosis, Lactic; Aged; Alcohol Drinking; Continuous Renal Replacement Therapy; Diabetes Mellitus, T | 2019 |
Authors' reply to the comment on « Metformin-Related lactic acidosis with acute kidney injury: results of a French observationnal multicenter study ».
Topics: Acidosis, Lactic; Acute Kidney Injury; Humans; Hypoglycemic Agents; Metformin | 2020 |
Comment on 'metformin-related lactic acidosis with acute kidney injury: results of a French observational multicenter study'.
Topics: Acidosis, Lactic; Acute Kidney Injury; Humans; Hypoglycemic Agents; Metformin | 2020 |
A patient with metformin-associated lactic acidosis successfully treated with continuous renal replacement therapy: a case report.
Topics: Acidosis, Lactic; Aged; Continuous Renal Replacement Therapy; Diabetes Mellitus, Type 2; Female; Hum | 2019 |
The safety and pharmacokinetics of metformin in patients with chronic liver disease.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Chronic Disease; Comorbidity; Cross-Sectional Stud | 2020 |
[Severe Metformin-Associated Lactic Acidosis in a 67-Year-Old Patient].
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Hospitals; Humans; Hypoglycemic Agents; Intensive | 2020 |
The Long-term Effects of Metformin on Patients With Type 2 Diabetic Kidney Disease.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Cause of Death; Cohort Studies; Diabetes Mellitus, Type 2 | 2020 |
Successful Dialysis Treatment of Metformin Associated Lactic Acidosis, Report of Two Cases.
Topics: Acidosis, Lactic; Adult; Drug Overdose; Female; Humans; Metformin; Renal Dialysis; Suicide, Attempte | 2020 |
Extracorporeal treatment of metforminassociated lactic acidosis in clinical practice: a retrospective cohort study.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Female; Humans; Male; Metformin; Middle Aged; Renal Dialy | 2020 |
The Effect of Residual Confoundingon Mortality in Metformin-Associated Lactic Acidosis.
Topics: Acidosis, Lactic; Humans; Hydrogen-Ion Concentration; Lactic Acid; Metformin; Risk Factors | 2020 |
In Reply: More Questions than Answers in Metformin-Associated Lactic Acidosis (MALA).
Topics: Acidosis, Lactic; Humans; Hydrogen-Ion Concentration; Lactic Acid; Metformin; Risk Factors | 2020 |
Hospitalization for Lactic Acidosis Among Patients With Reduced Kidney Function Treated With Metformin or Sulfonylureas.
Topics: Acidosis, Lactic; Aged; Cohort Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; G | 2020 |
Metformin Associated Lactic Acidosis in Clinical Practice - A Case Series.
Topics: Acidosis, Lactic; Aged; Comorbidity; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Humans; H | 2021 |
Mortality and renal prognosis in isolated metformin-associated lactic acidosis treated with continuous renal replacement therapy and citrate-calcium-anticoagulation.
Topics: Acidosis, Lactic; Anticoagulants; Calcium; Citrates; Continuous Renal Replacement Therapy; Humans; H | 2020 |
Extracorporeal membrane oxygenation with continuous renal replacement therapy to treat metformin-associated lactic acidosis: A case report.
Topics: Acidosis, Lactic; Aged; Electrocardiography; Extracorporeal Membrane Oxygenation; Female; Humans; Hy | 2020 |
A Pharmacokinetic Analysis of Hemodialysis for Metformin-Associated Lactic Acidosis.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Male; Metabolic Clearance | 2021 |
Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes.
Topics: Acidosis; Acidosis, Lactic; Aged; China; Coronavirus Infections; COVID-19; Diabetes Mellitus, Type 2 | 2020 |
Metformin-associated lactic acidosis: reinforcing learning points.
Topics: Acidosis, Lactic; Acute Kidney Injury; Bicarbonates; Continuous Renal Replacement Therapy; Diabetes | 2020 |
Comment on Flory et al. Reports of Lactic Acidosis Attributed to Metformin, 2015-2018. Diabetes Care 2020;43:244-246.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin | 2020 |
Response to Comment on Flory et al. Reports of Lactic Acidosis Attributed to Metformin, 2015-2018. Diabetes Care 2020;43:244-246.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin | 2020 |
Identifying patients with metformin associated lactic acidosis in the emergency department.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Creatinine; Emergency Service, Hospital; Female; Humans; | 2020 |
A Study of Associations Between Plasma Metformin Concentration, Lactic Acidosis, and Mortality in an Emergency Hospitalization Context.
Topics: Acidosis, Lactic; Aged; Emergency Service, Hospital; Female; Hospital Mortality; Humans; Intensive C | 2020 |
Metformin in chronic kidney disease: a strong dose of caution.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Renal Insuffici | 2020 |
Drug-Drug Interactions Involving Renal OCT2/MATE Transporters: Clinical Risk Assessment May Require Endogenous Biomarker-Informed Approach.
Topics: Acidosis, Lactic; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Antiviral Agents; Area Under Curve; | 2021 |
Metformin induced lactic acidosis impaired response of cancer cells towards paclitaxel and doxorubicin: Role of monocarboxylate transporter.
Topics: A549 Cells; Acidosis, Lactic; Animals; Antineoplastic Agents; Breast Neoplasms; Diabetes Mellitus, T | 2021 |
[Lactic Acidosis after Cardiac Surgery Treated by Continuous Renal Replacement Therapy in a Patient on Metformin;Report of a Case].
Topics: Acidosis, Lactic; Cardiac Surgical Procedures; Continuous Renal Replacement Therapy; Humans; Hypogly | 2020 |
Perioperative management of metformin: is there something new?
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Perioperative P | 2020 |
Metformin -associated lactic acidosis.
Topics: Acidosis, Lactic; Contraindications; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; | 2020 |
The usefulness of measuring the anion gap in diagnosing metformin-associated lactic acidosis: a case series.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Aged; Aged, 80 and over; Anions; Cations; Diabetes Mellitus | 2021 |
Lactic acidosis incidence with metformin in patients with type 2 diabetes and chronic kidney disease: A retrospective nested case-control study.
Topics: Acidosis, Lactic; Aged; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; | 2021 |
Cholinergic and metabolic effects of metformin in mouse brain.
Topics: Acetylcholine; Acidosis, Lactic; Animals; Choline; Glucose; Hypoglycemic Agents; Hypothalamus; Lacti | 2021 |
[Continuing or stopping metformin in patients with type 2 diabetes exposed to SARS-CoV-2 ?]
Topics: Acidosis, Lactic; COVID-19; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; SARS- | 2021 |
Therapeutic Strategy for Metformin-Associated Lactic Acidosis.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin | 2021 |
Plasma Metformin Levels at Almost 24 Hours Would Help With the Delicate Decision to Start Renal Replacement Therapy: We Disagree as Lactate That Is More Widely and Early Available Should Be a Much Better Trigger to Start Renal Replacement Therapy!
Topics: Acidosis, Lactic; Humans; Lactic Acid; Metformin; Renal Replacement Therapy | 2021 |
Long-term metformin use and risk of pneumonia and related death in type 2 diabetes: a registry-based cohort study.
Topics: Acidosis, Lactic; Adult; Asian People; Blood Glucose; China; Cohort Studies; Diabetes Mellitus, Type | 2021 |
The extrapyramidal syndromes of chronic kidney disease and dialysis (EPS-CKDD): diagnostic criteria, risk factors and prognosis.
Topics: Acidosis, Lactic; Basal Ganglia Diseases; Child, Preschool; Diabetes Mellitus, Type 2; Female; Human | 2022 |
Case 15-2021: A 76-Year-Old Woman with Nausea, Diarrhea, and Acute Kidney Failure.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Coronary Artery Disease; Creatinine; Diabetes Mellitus, | 2021 |
Metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agent | 2021 |
Metformin use may be associated with reduced risk-adjusted mortality in patients with AKI and diabetes in the ICU: If associated with lactic acidosis, especially in shocked patients, we need to eliminate it as quickly as possible through RRT!
Topics: Acidosis, Lactic; Acute Kidney Injury; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Inten | 2021 |
[Accumulation of Metformin-associated Lactic Acidosis].
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Diagnosis, Differential; Femal | 2017 |
Refining metformin prescribing in New Zealand.
Topics: Acidosis, Lactic; Comorbidity; Diabetes Mellitus, Type 2; Drug Dosage Calculations; Glomerular Filtr | 2017 |
Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Case-Control Studies; Diabetes Melli | 2017 |
Metformin-associated lactic acidosis: Moving towards a new paradigm?
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin | 2017 |
Metformin Does Not Induce Hyperlactatemia in Patients Admitted to Internal Medicine Ward.
Topics: Acidosis, Lactic; Contraindications, Drug; Diabetes Mellitus; Hospitalization; Humans; Hyperlactatem | 2017 |
Risk of acute kidney injury and survival in patients treated with Metformin: an observational cohort study.
Topics: Acidosis, Lactic; Acute Kidney Injury; Age Distribution; Aged; Cohort Studies; Comorbidity; Diabetes | 2017 |
Metformin is not associated with lactic acidosis in patients with diabetes undergoing coronary artery bypass graft surgery: a case control study.
Topics: Acidosis, Lactic; Aged; Case-Control Studies; Coronary Artery Bypass; Diabetes Mellitus, Type 2; Fem | 2017 |
Targeting Oxygen-Sensing Prolyl Hydroxylase for Metformin-Associated Lactic Acidosis Treatment.
Topics: Acidosis, Lactic; Adenine; Animals; Disease Models, Animal; Enzyme Inhibitors; Gluconeogenesis; Kidn | 2017 |
Diabetes mellitus: Complex interplay between metformin, AKI and lactic acidosis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metfo | 2017 |
Metformin use in renal disease.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Renal Insuffici | 2017 |
Combined metformin-associated lactic acidosis and euglycemic ketoacidosis.
Topics: Acidosis, Lactic; Aged; Blood Glucose; Canagliflozin; Diabetes Mellitus, Type 2; Drug Therapy, Combi | 2017 |
Lactic acidosis associated (or induced by) metformin.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Male; Metformin; Mid | 2017 |
High-volume continuous venovenous hemodiafiltration plus resin hemoperfusion improves severe metformin-associated toxicity.
Topics: Acidosis, Lactic; Adult; Drug Overdose; Female; Hemodiafiltration; Hemoperfusion; Humans; Hypoglycem | 2018 |
Risk of Metformin-Associated Lactic Acidosis (MALA) in Patients After Gastric Bypass Surgery.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Female; Gastric Bypass; Humans; Hypoglycemic Agents; La | 2018 |
Metformin intoxication: Vasopressin's key role in the management of severe lactic acidosis.
Topics: Acidosis, Lactic; Female; Hemodynamics; Humans; Hypoglycemic Agents; Metformin; Middle Aged; Severit | 2018 |
Safety of Metformin Therapy in Patients with Type 2 Diabetes Living on an Oxygen-Deficient Plateau, Tibet, China.
Topics: Acidosis, Lactic; Adult; Altitude; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Human | 2018 |
[Metformin-associated lactic acidosis. Report of one case].
Topics: Acidosis, Lactic; Bicarbonates; Diabetes Mellitus, Type 2; Female; Hemofiltration; Humans; Hypoglyce | 2017 |
Further clarifying the relationship between metformin, acute kidney injury and lactic acidosis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Humans; Hypoglycemic Agents; Metformin | 2017 |
Clarifying the relationship between metformin, acute kidney injury and lactic acidosis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Humans; Hypoglycemic Agents; Metformin | 2017 |
Metformin-associated lactic acidosis mimicking ischaemic bowel.
Topics: Abdominal Pain; Acidosis, Lactic; Aged; Diabetes Mellitus; Diagnosis, Differential; Emergency Medica | 2018 |
Metformin-Induced Lactic Acidosis (MILA): Review of current diagnostic paradigm.
Topics: Acidosis, Lactic; Acute Kidney Injury; Creatinine; Diabetes Mellitus, Type 2; Humans; Hypoglycemic A | 2018 |
Clinical and Laboratory Features of Metformin Intoxication in Suicidal Patients Attending an Intensive Care Unit.
Topics: Acidosis, Lactic; Adult; Creatinine; Cross-Sectional Studies; Female; Humans; Hypoglycemic Agents; I | 2018 |
Range of therapeutic metformin concentrations in clinical blood samples and comparison to a forensic case with death due to lactic acidosis.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Chromatography, Liquid; Diabetes Mellitus, Type 2; | 2018 |
Metformin associated lactic acidosis: a case series of 28 patients treated with sustained low-efficiency dialysis (SLED) and long-term follow-up.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Female; Follow-Up Studies; Humans; Hypoglycemic Agents; M | 2018 |
Metformin-associated lactic acidosis: Are we looking in the right direction?
Topics: Acidosis, Lactic; Acute Kidney Injury; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metfo | 2020 |
[Treatment with metformin in type 2 diabetes mellitus - new routines when renal function is reduced and in connection with administration of iodine contrast media].
Topics: Acidosis, Lactic; Body Size; Contrast Media; Diabetes Mellitus, Type 2; Female; Glomerular Filtratio | 2018 |
Severe lactic acidosis and hypoglycemia due to acute metformin intoxication in a dog.
Topics: Acidosis, Lactic; Animals; Dog Diseases; Dogs; Female; Glucose; Hypoglycemia; Hypoglycemic Agents; I | 2018 |
Risk of lactic acidosis in type 2 diabetes patients using metformin: A case control study.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Case-Control Studies; Comorbidity; Denmark; Diabetes Mell | 2018 |
Hemodialysis in metformin-associated lactic acidosis due to acute overdose in a metformin-naïve patient.
Topics: Acidosis, Lactic; Drug Overdose; Female; Humans; Hypoglycemic Agents; Metformin; Renal Dialysis; You | 2018 |
Should Metformin Be First-line Therapy for Patients With Type 2 Diabetes and Chronic Kidney Disease?: Informed Patients Should Decide.
Topics: Acidosis, Lactic; Cohort Studies; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; | 2018 |
Association of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function: A Community-Based Cohort Study.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Female; Glomerular Filtration Rate; Humans; Hypog | 2018 |
Involvement of organic cation transporter 2 in the metformin-associated increased lactate levels caused by contrast-induced nephropathy.
Topics: Acidosis, Lactic; Acute Kidney Injury; Animals; Cell Line; Contrast Media; Disease Models, Animal; H | 2018 |
Recurrent hypoglycemia secondary to metformin toxicity in the absence of co-ingestions: a case report.
Topics: Acidosis, Lactic; Anti-Obesity Agents; Female; Humans; Hypoglycemia; Metformin; Polycystic Ovary Syn | 2018 |
Metformin misuse in chronic kidney disease.
Topics: Acidosis, Lactic; Aged; Contraindications, Drug; Diabetes Mellitus, Type 2; Female; Humans; Hypoglyc | 2020 |
[A case of severe metformin-associated lactic acidosis treated with CVVHDF and regional anticoagulation with sodium citrate].
Topics: Acidosis, Lactic; Aged; Anticoagulants; Bronchial Spasm; Combined Modality Therapy; Female; Furosemi | 2018 |
Using a semi-mechanistic model to identify the main sources of variability of metformin pharmacokinetics.
Topics: Acidosis, Lactic; Administration, Oral; Adult; Biological Availability; Biological Variation, Indivi | 2019 |
Lactic Acidosis, Metformin Use, and Dose-Response Association.
Topics: Acidosis, Lactic; Cohort Studies; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin | 2018 |
Lactic Acidosis, Metformin Use, and Dose-Response Association.
Topics: Acidosis, Lactic; Cohort Studies; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin | 2018 |
Lactic Acidosis, Metformin Use, and Dose-Response Association.
Topics: Acidosis, Lactic; Cohort Studies; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin | 2018 |
Lactic Acidosis, Metformin Use, and Dose-Response Association-Reply.
Topics: Acidosis, Lactic; Cohort Studies; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin | 2018 |
Metformin use was linked to hospitalization for acidosis at 6 y only in patients with eGFR < 30 mL/min/1.73 m2.
Topics: Acidosis; Acidosis, Lactic; Cohort Studies; ErbB Receptors; Hospitalization; Humans; Hypoglycemic Ag | 2018 |
Sustained low-efficiency dialysis for metformin-associated lactic acidosis in patients with acute kidney injury.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; H | 2019 |
Metformin-associated lactic acidosis precipitated by liraglutide use: adverse effects of aggressive antihyperglycaemic therapy.
Topics: Acidosis, Lactic; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Drug-Related Side Effects and Adve | 2018 |
[Metformin and surgery before general anaesthesia].
Topics: Acidosis, Lactic; Anesthesia, General; Comorbidity; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2018 |
[Metformin-associated lactic acidosis : myth or reality ?]
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin | 2019 |
Inconsistencies in Reporting Studies of Lactic Acidosis.
Topics: Acidosis, Lactic; Cohort Studies; Humans; Hypoglycemic Agents; Metformin; Risk Factors | 2019 |
Inconsistencies in Reporting Studies of Lactic Acidosis-Reply.
Topics: Acidosis, Lactic; Cohort Studies; Humans; Hypoglycemic Agents; Metformin | 2019 |
A 35-Year-Old Woman With Shock, Pulseless Electrical Activity Arrest, and Hemodynamic Collapse.
Topics: Abdominal Pain; Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Diagnosis, Differential; Drug-Re | 2019 |
Lactic acidosis due to metformin in type 2 diabetes mellitus and chronic kidney disease stage 3-5: is it significant?
Topics: Acidosis, Lactic; Creatinine; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Moni | 2019 |
Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose.
Topics: Acetaminophen; Acidosis, Lactic; Analgesics, Non-Narcotic; Case-Control Studies; Drug Overdose; Emer | 2019 |
Lactic acidosis associated with metformin in patients with moderate to severe chronic kidney disease: study protocol for a multicenter population-based case-control study using health databases.
Topics: Acidosis, Lactic; Case-Control Studies; Databases, Factual; Diabetes Mellitus, Type 2; Female; Follo | 2019 |
A new perspective on the biguanide, metformin therapy in type 2 diabetes and lactic acidosis.
Topics: Acidosis, Lactic; Biguanides; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Pro | 2019 |
Metformin overdose: A serious iatrogenic complication-Western France Poison Control Centre Data Analysis.
Topics: Acidosis, Lactic; Adolescent; Adult; Age Factors; Aged; Data Analysis; Databases, Factual; Diabetes | 2019 |
Metformin-associated lactic acidosis treated successfully by peritoneal dialysis in a resource limited setting: case report.
Topics: Acidosis, Lactic; Adolescent; Female; Humans; Hypoglycemic Agents; Metformin; Peritoneal Dialysis; T | 2019 |
Metformin-Associated Lactic Acidosis Presenting Like Acute Mesenteric Ischemia.
Topics: Acidosis, Lactic; Creatinine; Diabetes Mellitus, Type 2; Emergency Service, Hospital; Female; Humans | 2019 |
Follow-up of glycemic index before and after Ramadan fasting in type 2 diabetes patients under antidiabetic medications.
Topics: Acidosis, Lactic; Adult; Aged; Blood Glucose; Creatinine; Diabetes Mellitus, Type 2; Fasting; Female | 2019 |
Metformin-related lactic acidosis with acute kidney injury: results of a French observational multicenter study.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Female; Humans; Hydrogen-Ion Concent | 2020 |
An initiative to prevent the adverse effects of metformin.
Topics: Acidosis, Lactic; Cooperative Behavior; Humans; Hypoglycemic Agents; Interdisciplinary Communication | 2013 |
Feeling blue with metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Aged; Cardiopulmonary Resuscitation; Enzyme Inhibitors; Female; Heart Arrest; Huma | 2013 |
Metformin overdose-induced hypoglycemia in the absence of other antidiabetic drugs.
Topics: Acidosis, Lactic; Adolescent; Drug Overdose; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Hypo | 2013 |
The Role of Metformin in Metformin-Associated Lactic Acidosis (MALA): Case Series and Formulation of a Model of Pathogenesis.
Topics: Acidosis, Lactic; Aged; Creatinine; Female; Humans; Hydrogen-Ion Concentration; Lactic Acid; Male; M | 2013 |
The prognostic value of blood pH and lactate and metformin concentrations in severe metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Drug Monitoring; Drug Overdose; Female; Humans; Hy | 2013 |
Case records of the Massachusetts General Hospital. Case 23-2013. A 54-year-old woman with abdominal pain, vomiting, and confusion.
Topics: Abdominal Pain; Acidosis, Lactic; Confusion; Diabetes Mellitus, Type 2; Diagnosis, Differential; Fem | 2013 |
Metformin use in chronic kidney disease: new evidence to guide dosing.
Topics: Acidosis, Lactic; Biomarkers, Pharmacological; Blood Glucose; Humans; Metformin; Renal Insufficiency | 2013 |
[Toxicity of metformin, pro- or con- a future restriction to its contraindications?].
Topics: Acidosis, Lactic; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metform | 2013 |
Metformin toxicity: a report of 204 cases from Iran.
Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Aged, 80 and over; Child; Female; Humans; Hypoglycemia; H | 2013 |
Severe lactic acidosis and acute pancreatitis associated with cimetidine in a patient with type 2 diabetes mellitus taking metformin.
Topics: Acidosis, Lactic; Aged, 80 and over; Cimetidine; Diabetes Mellitus, Type 2; Drug Interactions; Drug | 2013 |
Letter to the editor.
Topics: Acidosis, Lactic; Female; Humans; Hypoglycemic Agents; Metformin | 2014 |
Case 23-2013: a 54-year-old woman with metformin toxicity.
Topics: Acidosis, Lactic; Female; Humans; Lactic Acid; Metformin | 2013 |
Case 23-2013: a 54-year-old woman with metformin toxicity.
Topics: Acidosis, Lactic; Female; Humans; Lactic Acid; Metformin | 2013 |
Case 23-2013: a 54-year-old woman with metformin toxicity.
Topics: Acidosis, Lactic; Female; Humans; Lactic Acid; Metformin | 2013 |
Case 23-2013: a 54-year-old woman with metformin toxicity.
Topics: Acidosis, Lactic; Female; Humans; Lactic Acid; Metformin | 2013 |
Case 23-2013: a 54-year-old woman with metformin toxicity.
Topics: Acidosis, Lactic; Female; Humans; Lactic Acid; Metformin | 2013 |
Fatal metformin overdose: case report and postmortem biochemistry contribution.
Topics: Acidosis, Lactic; Aged; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Drug Overdo | 2014 |
Metformin accumulation: lactic acidosis and high plasmatic metformin levels in a retrospective case series of 66 patients on chronic therapy.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Chronic Disease; Creatinine; | 2014 |
Lactic acidosis induced by metformin in a chronic hemodialysis patient with diabetes mellitus type 2.
Topics: Acidosis, Lactic; Aged; Chronic Disease; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Inc | 2014 |
An unusual case of metformin associated lactic acidosis.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Risk Factors | 2002 |
Metformin-associated lactic acidosis in an older adult after colonoscopy: an uncommon trigger for a rare complication.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged, 80 and over; Colonoscopy; Female; Humans; Hypoglycemic | 2013 |
Metformin accumulation without hyperlactataemia and metformin-induced hyperlactataemia without metformin accumulation.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Hypersensitivi | 2014 |
The enigma of metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Female; Humans; Male; Metformin | 2014 |
[Metformin-associated lactic acidosis in the Intensive Care Unit].
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Bicarbonates; Combined Modality Therapy; Diabetes Mellitu | 2014 |
Metformin in peritoneal dialysis: a pilot experience.
Topics: Acidosis, Lactic; Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin | 2014 |
Metformin-induced lactic acidosis associated with multiorganic failure.
Topics: Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Metformin; | 2013 |
Prescription-medication sharing among family members: an unrecognized cause of a serious drug adverse event in a patient with impaired renal function.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Drug-Related Side Effects | 2015 |
Metformin OK in CKD?
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Renal Insuffici | 2014 |
Risk of lactic acidosis or elevated lactate concentrations in metformin users with renal impairment: a population-based cohort study.
Topics: Acidosis, Lactic; Adult; Aged; Cohort Studies; Comorbidity; Diabetes Mellitus, Type 2; Female; Human | 2014 |
Acute renal failure and metformin-associated lactic acidosis following colonoscopy.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Colonoscopy; Diabetes Mellitus, Type 2; Female; Humans; | 2014 |
Incidence of lactic acidosis in patients with type 2 diabetes with and without renal impairment treated with metformin: a retrospective cohort study.
Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Aged, 80 and over; Databases, Factual; Diabetes Mellitus, | 2014 |
Metformin-associated lactic acidosis presenting as an ischemic gut in a patient who then survived a cardiac arrest: a case report.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Female; Heart Arrest; Humans; Hypoglycemic Agents | 2014 |
Acute metformin intoxication: 2012 experience of Emergency Departement of Lodi, Italy.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Emergency Service, Hospital; Female; Hemodynamics | 2014 |
Pharmacist review prevents evolving metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Aged; Community Pharmacy Services; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2014 |
My patient's diabetic kidney disease has progressed to stage 4; should I discontinue metformin?
Topics: Acidosis, Lactic; Canada; Diabetic Nephropathies; Disease Progression; Dose-Response Relationship, D | 2014 |
Comment on 'A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure'.
Topics: Acidosis, Lactic; Diabetes Mellitus; Glomerular Filtration Rate; Guideline Adherence; Humans; Hypogl | 2015 |
Metformin-associated lactic acidosis and temporary ileostomy: a case report.
Topics: Acidosis, Lactic; Adverse Drug Reaction Reporting Systems; Aged; Diabetes Mellitus, Type 2; Drug Adm | 2014 |
Metformin-related acidosis in a woman while performing Haj: a conservative approach.
Topics: Acidosis, Lactic; Dehydration; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Islam | 2015 |
How does current diabetes care compare with landmark clinical studies?
Topics: Acidosis, Lactic; Diabetes Mellitus; Glomerular Filtration Rate; Guideline Adherence; Humans; Hypogl | 2015 |
Use of metformin in chronic kidney disease should continue to be based on common sense in the absence of an evidence base.
Topics: Acidosis, Lactic; Diabetes Mellitus; Glomerular Filtration Rate; Guideline Adherence; Humans; Hypogl | 2015 |
Hyperlactataemia and clinical severity of acute metformin overdose.
Topics: Acidosis, Lactic; Acute Disease; Adolescent; Adult; Aged; Drug Overdose; Female; Humans; Hyperlactat | 2015 |
Lactic Acidosis in a Patient with Type 2 Diabetes Mellitus.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Biomarkers; Diabetes Mellitus, Type 2; Fatal Outcome; Human | 2015 |
Metformin utilisation in Australian community and aged care settings.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Australia; Contraindications; Diabetes Mellitus, Type 2; | 2015 |
Impact of Japanese regulatory action on metformin-associated lactic acidosis in type II diabetes patients.
Topics: Acidosis, Lactic; Adult; Aged; Cohort Studies; Data Collection; Databases, Factual; Diabetes Mellitu | 2015 |
Metformin should not be contraindicated in patients with type 2 diabetes and mild to moderate renal impairment.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Renal Insuffici | 2015 |
[Metformin-induced lactic acidosis : Severe symptoms with difficult diagnostics].
Topics: Acidosis, Lactic; Acute Kidney Injury; Carbon Dioxide; Diabetes Mellitus, Type 2; Epinephrine; Human | 2015 |
Using metformin in the presence of renal disease.
Topics: Acidosis, Lactic; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Kidney | 2015 |
Safety of metformin in patients with chronic obstructive pulmonary disease and type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Biomarkers; Diabetes Mellitus, Type 2; Female; Hum | 2015 |
Metformin Use in Type 2 Diabetes Mellitus With CKD: Is It Time to Liberalize Dosing Recommendations?
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Renal Insuffici | 2015 |
Does lactate account for all of the increase in anion gap in cases of metformin-induced lactic acidosis?
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Shock, | 2015 |
[Non-fatal hyperkalemia in lactic acidosis due to metformin overdose. Report of one case].
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Drug Overdose; Humans; Hyperkalemia; Hypoglycemic | 2015 |
Lacticemia After Acute Overdose of Metformin in an Adolescent Managed Without Intravenous Sodium Bicarbonate or Extracorporeal Therapy.
Topics: Acidosis, Lactic; Adolescent; Drug Overdose; Female; Humans; Hypoglycemic Agents; Metformin; Renal D | 2015 |
Comment on 'A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure'.
Topics: Acidosis, Lactic; Diabetes Mellitus; Glomerular Filtration Rate; Guideline Adherence; Humans; Hypogl | 2015 |
Unexpectedly long half-life of metformin elimination in cases of metformin accumulation.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Algorithms; Blood; Diabetes Mellitus, Type 2; Diabetic | 2016 |
Metformin Poisoning: A Debate on Recommendations for Extracorporeal Treatment.
Topics: Acidosis, Lactic; Humans; Metformin; Renal Dialysis | 2015 |
The authors reply.
Topics: Acidosis, Lactic; Humans; Metformin; Renal Dialysis | 2015 |
Prognosis of patients presenting extreme acidosis (pH <7) on admission to intensive care unit.
Topics: Acidosis; Acidosis, Lactic; Acidosis, Respiratory; Adult; Aged; Diabetes Mellitus; Extracorporeal Me | 2016 |
Metformin-Associated Lactic Acidosis Presenting as Acute ST-Elevation Myocardial Infarction.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Diagnosis, Differential; Electrocardiography; Female; H | 2016 |
In Reply to 'Restricting Metformin in CKD: Continued Caution Warranted'.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Renal Insuffici | 2015 |
Restricting Metformin in CKD: Continued Caution Warranted.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Renal Insuffici | 2015 |
Lactic acidosis and severe septic shock in metformin users: a cohort study.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Cohort Studies; Female; Hospital Mortality; Humans; Hypog | 2016 |
INTRAVENOUS CONTRAST IN PATIENTS WITH DIABETES ON METFORMIN: NEW COMMON SENSE GUIDELINES.
Topics: Acidosis, Lactic; Administration, Intravenous; Contrast Media; Diabetes Mellitus, Type 2; Drug Inter | 2016 |
Myocardial injury and acute renal failure associated with lactic acidosis due to suicide attempt with metformin.
Topics: Acidosis, Lactic; Acute Kidney Injury; Emergency Medical Services; Humans; Hypoglycemic Agents; Male | 2016 |
Dose-related effects of metformin on acid-base balance and renal function in patients with diabetes who develop acute renal failure: a cross-sectional study.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Cross-Sectional Studies; | 2016 |
[New aspects in prevention and therapy of diabetic nephropathy].
Topics: Acidosis, Lactic; Diabetic Nephropathies; Humans; Hyperglycemia; Hypertension; Hypoglycemic Agents; | 2016 |
Lactic acidosis: relationship between metformin levels, lactate concentration and mortality.
Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; Hum | 2016 |
Lactic Acidosis in Diabetic Population: Is Metformin Implicated? Results of a Matched Case-Control Study Performed on the Type 2 Diabetes Population of Grenoble Hospital University.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Di | 2016 |
A Fatal Case of Metformin-associated Lactic Acidosis.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Fatal Outcome; Female; Fluid Therapy; Hemodiafilt | 2016 |
Lactic acidosis due to attempted suicide with metformin overdose: A case report.
Topics: Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Drug Overdose; Humans; Hypoglycemic Agents; Male | 2016 |
Retrospective analysis of lactic acidosis-related parameters upon and after metformin discontinuation in patients with diabetes and chronic kidney disease.
Topics: Acidosis, Lactic; Adult; Aged; Cohort Studies; Comorbidity; Creatinine; Diabetes Mellitus, Type 2; F | 2016 |
Prognosis of extremely severe lactic acidosis in metformin-treated patients with septic shock: continuous (?) renal replacement therapy in the spotlight!
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Prognosis; Rena | 2016 |
Skeletal muscle lactate overproduction during metformin intoxication: An animal study with reverse microdialysis.
Topics: Acidosis, Lactic; Animals; Glycolysis; Hypoglycemic Agents; Infusions, Parenteral; Lactic Acid; Metf | 2016 |
Metformin-Associated Lactic Acidosis in a Patient with Normal Renal Function.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Female; Humans; Kidney Function Tests; Lactic Aci | 2016 |
Epidemiology of lactic acidosis in type 2 diabetes patients with metformin in Japan.
Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Cohort Studies; Databases, Factual; Diabetes Mellitus, Ty | 2016 |
Metformin and lactic acidosis during shock: just the tip of the iceberg?
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Shock, Septic | 2016 |
[Chronic kidney diseases, metformin and lactic acidosis].
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Renal Insuffici | 2016 |
Metformin is also effective on lactic acidosis-exposed melanoma cells switched to oxidative phosphorylation.
Topics: Acidosis, Lactic; Adaptation, Physiological; Cell Death; Cell Line, Tumor; Cell Movement; Cell Proli | 2016 |
Should Restrictions Be Relaxed for Metformin Use in Chronic Kidney Disease? No, We Should Never Again Compromise Safety!
Topics: Acidosis, Lactic; Acute Kidney Injury; Creatinine; Diabetes Mellitus, Type 2; Glomerular Filtration | 2016 |
Should Restrictions Be Relaxed for Metformin Use in Chronic Kidney Disease? Yes, They Should Be Relaxed! What's the Fuss?
Topics: Acidosis, Lactic; Acute Kidney Injury; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metfo | 2016 |
Development, implementation and outcome analysis of semi-automated alerts for metformin dose adjustment in hospitalized patients with renal impairment.
Topics: Acidosis, Lactic; Aged; Algorithms; Automation; Dose-Response Relationship, Drug; Drug Overdose; Fem | 2016 |
Metformin use and risk of lactic acidosis in people with diabetes with and without renal impairment: a cohort study in Denmark and the UK.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Case-Control Studies; Cohort Studies; Databases, Factual; | 2017 |
Peritoneal dialysis treatment of metformin-associated lactic acidosis in a diabetic nephropathy patient
.
Topics: Acidosis, Lactic; Aged; Diabetic Nephropathies; Dialysis Solutions; Humans; Hypoglycemic Agents; Kid | 2016 |
Risks of Metformin in Type 2 Diabetes and Chronic Kidney Disease: Lessons Learned from Taiwanese Data.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Hypoglycemic Agents; Me | 2017 |
Management of Sitagliptin and Metformin Combination Toxic Overdose.
Topics: Acidosis, Lactic; Adult; Drug Overdose; Female; Humans; Metformin; Sitagliptin Phosphate; Suicide, A | 2016 |
Lactic acidosis and the relationship with metformin usage: Case reports.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; Hospital Mortality; Hu | 2016 |
Use of Metformin for Cardiometabolic Risks in Psychiatric Practice: Need-to-Know Safety Issues.
Topics: Acidosis, Lactic; Antipsychotic Agents; Cohort Studies; Diabetes Mellitus, Type 2; Gastrointestinal | 2016 |
Association between Metformin Use and Risk of Lactic Acidosis or Elevated Lactate Concentration in Type 2 Diabetes.
Topics: Acidosis, Lactic; Adult; Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; H | 2017 |
Hemodialysis-refractory metformin-associated lactate acidosis with hypoglycemia, hypothermia, and bradycardia in a diabetic patient with belated diagnosis and chronic kidney disease
.
Topics: Acidosis, Lactic; Aged; Biomarkers; Bradycardia; Delayed Diagnosis; Diabetes Mellitus, Type 2; Drug | 2017 |
[Lactic acidosis due to metformin accumulation complicating acute gastroenteritis].
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Female; Gastroenteritis; Humans; Hypoglycemic Agents; M | 2016 |
Metformin-SGLT2, Dehydration, and Acidosis Potential.
Topics: Acidosis, Lactic; Aged, 80 and over; Dehydration; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Ag | 2017 |
Metformin-associated lactic acidosis treated with continuous renal replacement therapy.
Topics: Acidosis, Lactic; Aged; Hemodiafiltration; Humans; Hypoglycemic Agents; Male; Metformin | 2017 |
Treatment of Metformin Intoxication Complicated by Lactic Acidosis and Acute Kidney Injury: The Role of Prolonged Intermittent Hemodialysis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Humans; Hypoglycemic Agents; Male; Metformin; Renal Dia | 2017 |
[Lactic acidosis caused by metformin].
Topics: Acidosis, Lactic; Aged, 80 and over; Female; Humans; Hypoglycemic Agents; Metformin | 2008 |
Occult metformin toxicity in three patients with profound lactic acidosis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Diabetes Mellitus, Type 2; Emergency Service, Ho | 2011 |
Heeding clues to metformin-associated lactic acidosis: prompt response can save life.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus; Early Diagnosis; Female; Humans; Hypoglycemic Agents; Met | 2008 |
Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis.
Topics: Acidosis, Lactic; Aged; Case-Control Studies; Databases, Factual; Diabetes Mellitus, Type 2; Female; | 2008 |
Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro.
Topics: Acidosis, Lactic; Animals; Blood Glucose; Buformin; Cell Line; Cell Respiration; Cell Survival; Cult | 2008 |
Severe metformin intoxication treated with prolonged haemodialyses and plasma exchange.
Topics: Acidosis, Lactic; Adult; Drug Overdose; Female; Humans; Hypoglycemic Agents; Metformin; Plasma Excha | 2009 |
Metformin and lactic acidosis.
Topics: Acidosis, Lactic; Female; Humans; Hypoglycemic Agents; Metformin; Middle Aged | 2008 |
Metformin-associated lactic acidosis in an intensive care unit.
Topics: Acidosis, Lactic; Aged; Female; France; Humans; Hypoglycemic Agents; Intensive Care Units; Male; Med | 2008 |
Erlotinib-induced hepatitis complicated by fatal lactic acidosis in an elderly man with lung cancer.
Topics: Acidosis, Lactic; Adenocarcinoma; Aged; Antineoplastic Agents; Chemical and Drug Induced Liver Injur | 2009 |
Impact of acute kidney injury on metformin-associated lactic acidosis.
Topics: Academic Medical Centers; Acidosis, Lactic; Acute Kidney Injury; Aged; Anti-Bacterial Agents; Bicarb | 2009 |
Successful treatment of severe lactic acidosis caused by a suicide attempt with a metformin overdose.
Topics: Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Drug Overdose; Female; Humans; Hypoglycemic Agen | 2009 |
Balancing risk and benefit with oral hypoglycemic drugs.
Topics: Acidosis, Lactic; Administration, Oral; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans | 2009 |
Does glucose infusion exacerbate metformin-associated lactate acidosis? A case report.
Topics: Acidosis, Lactic; Acute Kidney Injury; Colectomy; Colitis, Ulcerative; Diabetes Mellitus, Type 2; Fe | 2009 |
Metformin-induced encephalopathy without lactic acidosis in a patient with contraindication for metformin.
Topics: Acidosis, Lactic; Brain Diseases; Contraindications; Diabetes Mellitus, Type 1; Diabetic Nephropathi | 2009 |
Metformin-associated lactic acidosis: a prognostic and therapeutic study.
Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Aged, 80 and over; Bicarbonates; Buffers; Cohort Studies; | 2009 |
Why check metformin levels?
Topics: Acidosis, Lactic; Drug Overdose; Humans; Hypoglycemic Agents; Metformin; Predictive Value of Tests; | 2009 |
Metformin associated lactic acidosis.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Metformin; Middle | 2009 |
Continuous venovenous haemodiafiltration for metformin-induced lactic acidosis.
Topics: Acidosis, Lactic; Aged; Critical Illness; Hemofiltration; Humans; Hypoglycemic Agents; Intensive Car | 2009 |
[Female patient with type 2 diabetes in coma with metabolic acidosis].
Topics: Acidosis, Lactic; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; Humans; Metformin | 2009 |
Metformin use in renal dysfunction: is a serum creatinine threshold appropriate?
Topics: Acidosis, Lactic; Creatinine; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Kidney Disease | 2009 |
Metformin toxicity.
Topics: Acidosis, Lactic; Bicarbonates; Humans; Hypoglycemic Agents; Metformin; Plasmapheresis; Renal Dialys | 2009 |
Three cases of severe metformin-related lactic acidosis.
Topics: Acidosis, Lactic; Aged; Critical Care; Diabetes Mellitus, Type 2; Fatal Outcome; Female; Humans; Hyp | 2010 |
Metformin and lactic acidosis. NSAIDs and renin-angiotensin-aldosterone system.
Topics: Acidosis, Lactic; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Humans; Hypogl | 2009 |
Metformin and lactic acidosis. Metformin: framed again?
Topics: Acidosis, Lactic; Acute Kidney Injury; Glomerular Filtration Rate; Humans; Hypoglycemic Agents; Metf | 2009 |
The art and science of medical guidelines: what we know and what we believe.
Topics: Acidosis, Lactic; Contrast Media; Diagnostic Imaging; Drug Interactions; Evidence-Based Medicine; Hu | 2010 |
Grapefruit juice improves glycemic control but exacerbates metformin-induced lactic acidosis in non-diabetic rats.
Topics: Acidosis, Lactic; Animals; Beverages; Blood Glucose; Citrus paradisi; Glucose Tolerance Test; Hypogl | 2009 |
Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication.
Topics: Acidosis, Lactic; Aged; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Oxygen Co | 2010 |
Severe metabolic acidosis secondary to coadministration of creatine and metformin, a case report.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Creatine; Diagnosis, Differential; Dietary Supplements | 2010 |
Life threatening lactic acidosis.
Topics: Acidosis, Lactic; Aged, 80 and over; Female; Humans; Hypoglycemic Agents; Metformin | 2010 |
pH 6.68--surviving severe metformin intoxication.
Topics: Acidosis, Lactic; Blood Gas Analysis; Diabetes Mellitus, Type 2; Hospitalization; Humans; Hypoglycem | 2010 |
Comparison of potential risks of lactic acidosis induction by biguanides in rats.
Topics: Acidosis, Lactic; Animals; Dose-Response Relationship, Drug; Female; Hypoglycemic Agents; Lactic Aci | 2010 |
How to explain a PaO2 of 140 mmHg in a venous line?
Topics: Acidosis, Lactic; Acute Kidney Injury; Blood Gas Analysis; Cell Respiration; Fatal Outcome; Humans; | 2009 |
Nearly fatal metabolic acidosis: septic or toxic?
Topics: Acidosis, Lactic; Aged; Female; Humans; Hypoglycemic Agents; Metformin | 2010 |
Cimetidine-induced lactic acidosis and acute pancreatitis.
Topics: Acidosis, Lactic; Acute Disease; Cimetidine; Diabetes Mellitus, Type 2; Drug Interactions; Female; G | 2010 |
Transient vision loss in a patient with metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Aged; Blindness; Emergencies; Female; Humans; Hypoglycemic Agents; Metformin | 2010 |
[Rapid blood pH recovery in comatose patients with lactic acidosis is life saving].
Topics: Acidosis, Lactic; Bicarbonates; Coma; Combined Modality Therapy; Female; Humans; Hydrogen-Ion Concen | 2010 |
Serum bicarbonate: can it be a marker of metformin induced acidosis in geriatrics?
Topics: Acidosis, Lactic; Aged; Bicarbonates; Biomarkers; Creatinine; Female; Humans; Hypoglycemic Agents; M | 2009 |
Metformin and contrast media.
Topics: Acidosis, Lactic; Contrast Media; Drug Interactions; Evidence-Based Medicine; Humans; Hypoglycemic A | 2010 |
Metformin-associated lactic acidosis treated with prolonged hemodialysis.
Topics: Acidosis, Lactic; Adult; Humans; Hypoglycemic Agents; Male; Metformin; Renal Dialysis; Treatment Out | 2011 |
Metformin-related lactic acidosis in patients with acute kidney injury.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Contraindications; Diabetes Mellitus, Type 2; Female; H | 2011 |
Can acute overdose of metformin lead to lactic acidosis?
Topics: Acidosis, Lactic; Adolescent; Adult; Child; Child, Preschool; Drug Overdose; Female; Humans; Hypogly | 2010 |
Limitations of metformin use in patients with kidney disease: are they warranted?
Topics: Acidosis, Lactic; Adolescent; Adult; Cohort Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathi | 2010 |
Diabetes, metformin and lactic acidosis.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus; Female; Humans; Lactic Acid; Male; Metformin; Middle Aged | 2011 |
Does metformin increase the risk of fatal or nonfatal lactic acidosis?
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Evidence-Based Medicine; Humans; Hypoglycemic Age | 2010 |
[Metformin treatment causes persisting lactic acidosis after cardiac arrest].
Topics: Acidosis, Lactic; Cardiopulmonary Resuscitation; Diabetes Mellitus, Type 2; Fatal Outcome; Heart Arr | 2010 |
Metformin-associated lactic acidosis: is it really just an association?
Topics: Acidosis, Lactic; Humans; Hypoglycemic Agents; Metformin | 2011 |
Outcome of severe lactic acidosis associated with metformin accumulation.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Metformin; Middle Aged; Retr | 2010 |
Metformin-associated lactic acidosis (MALA): clinical profile and outcomes in patients admitted to the intensive care unit.
Topics: Acidosis, Lactic; Australia; Diabetes Mellitus, Type 2; Humans; Intensive Care Units; Metformin | 2010 |
Lactic acidosis after concomitant treatment with metformin and tenofovir in a patient with HIV infection.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adenine; Aged; Anti-HIV Agents; Diabetes Mellitus, Type 2; Dr | 2011 |
Metformin-induced lactic acidosis: no one left behind.
Topics: Acidosis, Lactic; Female; Humans; Male; Metformin; Severity of Illness Index | 2011 |
[Short-lasting lactic acidosis after heart arrest].
Topics: Acidosis, Lactic; Heart Arrest; Humans; Hypoglycemic Agents; Metformin | 2011 |
Dialysis therapy for lactic acidosis caused by metformin intoxication: presentation of two cases.
Topics: Acidosis, Lactic; Adolescent; Bicarbonates; Diabetes Mellitus, Type 2; Dialysis Solutions; Humans; H | 2011 |
Acute kidney injury associated with metformin.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Female; Humans; Hypoglycemic Agents; Male; Metfo | 2011 |
Successful management of high-dose metformin intoxication. Role of vasopressin in the management of severe lactic acidosis.
Topics: Acidosis, Lactic; Adrenergic alpha-Agonists; Anti-Inflammatory Agents; Antidiuretic Agents; Drug Ove | 2010 |
Prolonged hemodialysis for severe metformin intoxication.
Topics: Acidosis, Lactic; Acute Kidney Injury; Drug Overdose; Humans; Hypoglycemic Agents; Male; Metformin; | 2011 |
Metformin associated lactic acidosis: incidence and clinical correlation with metformin serum concentration measurements.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Early | 2011 |
Quiz page June 2011. Profound metabolic acidosis and abdominal pain in a diabetic patient on long-term hemodialysis.
Topics: Abdominal Pain; Acidosis, Lactic; Diabetic Nephropathies; Diagnosis, Differential; Follow-Up Studies | 2011 |
Transient vision loss in a patient with severe metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Acute Disease; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Humans; Hypoglyc | 2012 |
A case of lactic acidosis (LA) after administration of tenofovir and metformin in a diabetic patient with recently diagnosed HIV infection.
Topics: Acidosis, Lactic; Adenine; Anti-HIV Agents; Diabetes Mellitus, Type 2; HIV Infections; Humans; Hypog | 2011 |
Metformin-associated lactic acidosis in a patient with normal kidney function.
Topics: Acidosis, Lactic; Aged, 80 and over; Humans; Hypoglycemic Agents; Kidney; Male; Metformin; Risk Fact | 2012 |
Management of metformin-associated lactic acidosis by continuous renal replacement therapy.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Female; Humans; Lactates; Male; Metformin; Middle Aged; R | 2011 |
The nephrologist's role in metformin-induced lactic acidosis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibi | 2011 |
Metformin-induced lactic acidosis: usefulness of measuring levels and therapy with high-flux haemodialysis.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Aged, 80 and over; Comorbidity; Diabetes Mellitus, Type 2; | 2011 |
Metformin-associated lactic acidosis following acute kidney injury. Efficacious treatment with continuous renal replacement therapy.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Biomarkers; Creatinine; Female; Huma | 2012 |
Type 2 diabetes, metformin and lactic acidosis-defining the risk and promoting safe practice.
Topics: Acidosis, Lactic; Acute Kidney Injury; Female; Humans; Hypoglycemic Agents; Male; Metformin; Renal D | 2012 |
Metformin-associated lactic acidosis in Chinese patients with type II diabetes.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Amylases; Asian People; China; Creatinine; Diabete | 2011 |
Metformin intoxication requiring dialysis.
Topics: Acidosis, Lactic; Diabetes Mellitus; Female; Humans; Lactic Acid; Male; Metformin; Middle Aged; Rena | 2011 |
Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis.
Topics: Acidosis, Lactic; Animals; Diabetes Mellitus; Dose-Response Relationship, Drug; HEK293 Cells; Homozy | 2012 |
Rapid recovery from acute kidney injury in a patient with metformin-associated lactic acidosis and hypothermia.
Topics: Acidosis, Lactic; Acute Kidney Injury; Anti-Bacterial Agents; Comorbidity; Female; Humans; Hypotherm | 2012 |
Metformin-associated lactic acidosis masquerading as ischemic bowel.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus; Humans; Hypoglycemic Agents; Intestine, Large; Ischemia; | 2012 |
Fixed-dose glucose-lowering drug combinations: preventable lactic acidosis.
Topics: Acidosis, Lactic; Aged; Drug Combinations; Humans; Hypoglycemic Agents; Metformin; Middle Aged | 2012 |
Lactic acidosis, hypotension, and sensorineural hearing loss following intentional metformin overdose.
Topics: Acidosis, Lactic; Drug Overdose; Glyburide; Hearing Loss, Sensorineural; Humans; Hypoglycemia; Hypog | 2011 |
Metformin therapy in patients with chronic kidney disease.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Dose-Response Relationship, Dr | 2012 |
Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs.
Topics: Acidosis, Lactic; Animals; Drug Overdose; Hypoglycemic Agents; Infusions, Intravenous; Metformin; Ox | 2012 |
Lactic acidosis in a diabetic patient treated with metformin undergoing hepatic resection.
Topics: Acidosis, Lactic; Diabetes Mellitus; Humans; Hypoglycemic Agents; Liver; Male; Metformin; Middle Age | 2012 |
Discrepancies among consensus documents, guidelines, clinical practice and the legal framework for the treatment of type 2 diabetes mellitus patients.
Topics: Acidosis, Lactic; Aged; Carbamates; Consensus Development Conferences as Topic; Contraindications; D | 2012 |
[Metformin-associated lactic acidosis: incidence, diagnosis, prognostic factors and treatment].
Topics: Acidosis, Lactic; Aged; Humans; Hypoglycemic Agents; Incidence; Male; Metformin; Prognosis | 2012 |
[Metformin associated with lactic acidosis in treatment of type 2 diabetes].
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Contraindications; Denmark; Diabetes Mellitus, Type 2; Fe | 2012 |
[Metformin-associated lactic acidosis can be treated with continuous renal replacement therapy].
Topics: Acidosis, Lactic; Contraindications; Diabetes Mellitus, Type 2; Female; Hemofiltration; Humans; Hypo | 2012 |
[Treatment of metformin-associated lactate acidosis by haemodialysis].
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Metfor | 2012 |
Patient education on the benefit and risks of medications goes beyond metformin.
Topics: Acidosis, Lactic; Acute Kidney Injury; Female; Humans; Hypoglycemic Agents; Male; Metformin; Renal D | 2012 |
Toxicokinetics of metformin-associated lactic acidosis with continuous renal replacement therapy.
Topics: Acidosis, Lactic; Aged; Hemodiafiltration; Humans; Hypoglycemic Agents; Male; Metformin | 2012 |
The criteria for metformin-associated lactic acidosis: the quality of reporting in a large pharmacovigilance database.
Topics: Acidosis, Lactic; Databases, Factual; Humans; Hydrogen-Ion Concentration; Hypoglycemic Agents; Metfo | 2013 |
The importance of early haemodiafiltration in the treatment of lactic acidosis associated with the administration of metformin.
Topics: Acidosis, Lactic; Aged; Early Medical Intervention; Female; Hemodiafiltration; Humans; Hypoglycemic | 2012 |
Metformin overdose causes platelet mitochondrial dysfunction in humans.
Topics: Acidosis, Lactic; Blood Platelets; Dose-Response Relationship, Drug; Drug Overdose; Female; Humans; | 2012 |
Implications of ECASS III error on emergency department treatment of ischemic stroke.
Topics: Acidosis, Lactic; Female; Humans; Hypoglycemic Agents; Metformin | 2014 |
Monitoring of metformin-induced lactic acidosis in a diabetic patient with acute kidney failure and effect of hemodialysis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic | 2013 |
Acid base: back to the basics of Henderson-Hasselbalch.
Topics: Acidosis, Lactic; Humans; Hypoglycemic Agents; Intestine, Large; Ischemia; Male; Metformin | 2012 |
Survival after cardiopulmonary arrest with extreme hyperkalaemia and hypothermia in a patient with metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Aged; Cardiopulmonary Resuscitation; Heart Arrest; Humans; Hyperkalemia; Hypoglyce | 2012 |
Lactic acidosis in patients with diabetes.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Alcoholism; Diabetes Mellitus, T | 2013 |
Lactic acidosis in medical ICU - the role of diabetes mellitus and metformin.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Critical Care; Diabetes Mellitus, Type 2; Female; Hospi | 2012 |
[Pitfalls and precautions concerning the use of conventional oral antidiabetic drugs].
Topics: Acidosis, Lactic; Administration, Oral; Aged; Diabetes Mellitus, Type 2; Humans; Hypoglycemia; Hypog | 2002 |
[Metformin--sensible or nonsensible change of treatment in the post-operative phase].
Topics: Acidosis, Lactic; Blood Glucose; Diabetes Complications; Humans; Hypoglycemic Agents; Metformin; Pos | 2002 |
[Metformin-associated lactic acidosis with acute renal failure in type 2 diabetes mellitus].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Dose-Resp | 2002 |
[Metformin-associated lactic acidosis with acute renal failure in type 2 diabetes mellitus]].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Dose-Resp | 2002 |
Inappropriate prescription for metformin.
Topics: Acidosis, Lactic; Contraindications; Diabetes Mellitus, Type 2; Health Services Misuse; Heart Failur | 2002 |
Metformin-associated lactic acidosis after elective cervical spine fusion: a case report.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Cervical Vertebrae; Humans; Hypoglycemic Agents; Male; Me | 2002 |
[Metformin and anesthesia].
Topics: Acidosis, Lactic; Anesthesia; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin | 2002 |
[Hemodyalisis as therapy of choice in lactic acidosis associated with metformin].
Topics: Acidosis, Lactic; Female; Humans; Hypoglycemic Agents; Metformin; Renal Dialysis | 2002 |
Lactic acidemia associated with metformin.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; L | 2003 |
Contraindications to the use of metformin.
Topics: Acidosis, Lactic; Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metform | 2003 |
[Does a reduced kidney function (creatinine clearance 10-15 ml/min), without acidosis, increase the risk for the rise of lactic acidosis caused by metformin?].
Topics: Acidosis, Lactic; Contraindications; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Diabetic Neph | 2002 |
Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin.
Topics: Acidosis, Lactic; Animals; Biguanides; Disease Models, Animal; DNA-Binding Proteins; Hepatocytes; Ho | 2003 |
Metformin-associated lactic acidosis in a patient with liver disease.
Topics: Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Fatal Outcome; Humans; Hypoglycemic Agents; Live | 2003 |
[Lactic acidosis and biguanides: coincidence or negligence of prescribing guidelines].
Topics: Acidosis, Lactic; Biguanides; Drug Prescriptions; Guidelines as Topic; Hypoglycemic Agents; Metformi | 2003 |
[Metformin-associated lactic acidosis precipitated by acute renal failure].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Blood Gas Analysis; Diabetes Mellitus, Type 2; Female; | 2003 |
[Metformin-associated lactic acidosis remains a serious complication of metformin therapy].
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Diabetes Complications; Diabetes Mellitus, Type | 2003 |
A cautionary tale: fatal lactic acidosis complicating nucleoside analogue and metformin therapy.
Topics: Acidosis, Lactic; Anti-HIV Agents; Drug Therapy, Combination; Fatal Outcome; Humans; Hypoglycemic Ag | 2003 |
Case study: metformin-associated lactic acidosis: could orlistat be relevant?
Topics: Acidosis, Lactic; Anti-Obesity Agents; Anti-Ulcer Agents; Cimetidine; Drug Interactions; Female; Hum | 2003 |
Clinical pharmacology physiology conference: metformin and lactic acidosis (LA).
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; M | 2002 |
Heart failure: treatment and ethnic origin.
Topics: Acidosis, Lactic; Contraindications; Diabetes Mellitus, Type 2; Ethnicity; Heart Failure; Humans; Hy | 2003 |
Metformin-associated lactic acidosis and acute renal failure in a type 2 diabetic patient.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic | 2003 |
Metformin lactic acidosis, acute renal failure and rofecoxib.
Topics: Acidosis, Lactic; Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhib | 2003 |
[Metformin and lactic acidosis--fact or fiction? A review of current data].
Topics: Acidosis, Lactic; Clinical Trials as Topic; Contraindications; Diabetes Mellitus, Type 2; Humans; Hy | 2003 |
Unexpected survival from severe metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Aged; Contraindications; Diabetic Nephropathies; Female; Heart Arrest; Humans; Hyp | 2003 |
[Lactic acidosis as adverse effect of metformin].
Topics: Acidosis, Lactic; Contraindications; Humans; Hypoglycemic Agents; Metformin | 2003 |
Metformin and serious adverse effects.
Topics: Acidosis, Lactic; Adverse Drug Reaction Reporting Systems; Aged; Australia; Creatinine; Diabetes Mel | 2004 |
Metformin-induced encephalopathy without lactic acidosis.
Topics: Acidosis, Lactic; Aged; Brain Diseases; Diabetes Mellitus; Humans; Hypoglycemic Agents; Male; Metfor | 2004 |
[Lactic acidosis and acute abdomen from biguanide intoxication].
Topics: Abdomen, Acute; Acidosis, Lactic; Acute Kidney Injury; Aged; Diabetes Mellitus, Type 2; Female; Hemo | 2004 |
Toxic effects from metformin exposure.
Topics: Acidosis, Lactic; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Child; Drug Over | 2004 |
Metformin induced acute pancreatitis precipitated by renal failure.
Topics: Acidosis, Lactic; Acute Disease; Acute Kidney Injury; Angiotensin-Converting Enzyme Inhibitors; Anti | 2004 |
[Acute kidney failure and severe lactic acidosis caused by metformin successfully treated with hemodialysis].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Humans; Hypoglycemic Agents; Male; Metformin; Remission | 2004 |
Experiences of a poison center with metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Metformin; Middle | 2004 |
Why hold the metformin?
Topics: Acidosis, Lactic; Age Factors; Aged; Contrast Media; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 2004 |
Combination of intermittent haemodialysis and high-volume continuous haemofiltration for the treatment of severe metformin-induced lactic acidosis.
Topics: Acidosis, Lactic; Adult; Hemofiltration; Humans; Hypoglycemic Agents; Male; Metformin; Poisoning; Re | 2004 |
[Lactic acidosis in diabetic patient treated with metformin].
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Male; Metformin; Middle Ag | 2004 |
Do risk factors for lactic acidosis influence dosing of metformin?
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Dose-Response Relations | 2004 |
Metformin in type 2 diabetes.
Topics: Acidosis, Lactic; Contraindications; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; | 2004 |
Severe metformin intoxication with lactic acidosis in an adolescent.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adolescent; Drug Overdose; Female; Humans; Metformin; Renal D | 2005 |
Severe lactic acidosis complicating metformin overdose successfully treated with high-volume venovenous hemofiltration and aggressive alkalinization.
Topics: Acidosis, Lactic; Adolescent; Drug Overdose; Female; Fluid Therapy; Hemofiltration; Humans; Hypoglyc | 2005 |
Fulminant lactic acidosis in two patients with Type 2 diabetes treated with metformin.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Fatal Outcome; Female; Humans; Hypoglycemic Agent | 2005 |
[Metformin-associated lactic acidosis in a patient with pre-existing risk factors].
Topics: Acidosis, Lactic; Acute Kidney Injury; Contraindications; Diabetes Complications; Diabetes Mellitus, | 2005 |
Contraindications can damage your health--is metformin a case in point?
Topics: Acidosis, Lactic; Aging; Contraindications; Diabetes Mellitus, Type 2; Heart Diseases; Humans; Hypog | 2005 |
Lactic acidosis. Lactic acidosis associated with metformin use in treatment of type 2 diabetes mellitus.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Hum | 2005 |
Metformin-associated lactic acidosis precipitated by acute renal failure.
Topics: Acidosis, Lactic; Acute Kidney Injury; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Male; | 2006 |
Combined renal replacement therapy for severe metformin-induced lactic acidosis.
Topics: Acidosis, Lactic; Aged; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Hemofiltration; H | 2006 |
[Prevention of contrast nephropathy; guidelines from the Department Nephrology of the University Medical Centre Groningen].
Topics: Acidosis, Lactic; Contrast Media; Humans; Metformin; Netherlands; Rehydration Solutions; Renal Insuf | 2006 |
Use of an electronic medical record to detect patients at high risk of metformin-induced lactic acidosis.
Topics: Acidosis, Lactic; Aged; Creatinine; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Male; Me | 2006 |
Severe acidosis in patients taking metformin--rapid reversal and survival despite high APACHE score.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; APACHE; Diabetes Mellitus, Type 2; E | 2006 |
[Nephrotoxicity after the use of intravenous X-ray contrast media in a type 2 diabetic being treated with metformin].
Topics: Acidosis, Lactic; Aged; Contraindications; Contrast Media; Creatinine; Diabetes Mellitus, Type 2; Dr | 2006 |
Metformin-associated lactic acidosis treated with continuous renal replacement therapy.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus; Hemodiafiltration; Humans; Hypoglycemic Agents; Male; Met | 2006 |
Metformin-associated lactic acidosis in a patient with vertebral artery dissection.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Follow-Up Studies; Humans; Hypoglycemic Agents; Male; M | 2006 |
[Acute pancreatitis, acute kidney failure, metformin intoxication and villous rectal adenoma].
Topics: Acidosis, Lactic; Acute Kidney Injury; Adenoma, Villous; Aged; Colonic Neoplasms; Colonoscopy; Diabe | 2006 |
Metformin and antihypertensive therapy with drugs blocking the renin angiotensin system, a cause of concern?
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Conv | 2006 |
The perioperative management of metformin for the oral and maxillofacial surgery patient: risks and recommendations.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Monitoring, Int | 2007 |
Severe lactic acidosis and rhabdomyolysis following metformin and ramipril overdose.
Topics: Acidosis, Lactic; Antihypertensive Agents; Compartment Syndromes; Drug Overdose; Hemofiltration; Hum | 2007 |
Metformin: preventable lactic acidosis.
Topics: Acidosis, Lactic; Biguanides; Diabetes Mellitus, Type 2; Female; France; Humans; Male; Metformin | 2007 |
Increased prothrombin time and lactic acidosis: rofecoxib drug interaction with acenocoumarin and metformin.
Topics: Acenocoumarol; Acidosis, Lactic; Anticoagulants; Aortic Valve Stenosis; Cyclooxygenase 2 Inhibitors; | 2007 |
When a friend can become an enemy! Recognition and management of metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Aged; Bicarbonates; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents | 2007 |
[Metformin-related lactic acidosis in an 85-year-old woman].
Topics: Acidosis, Lactic; Aged, 80 and over; Contraindications; Creatinine; Diabetes Mellitus, Type 2; Fatal | 2007 |
A case of fatal intoxication from metformin.
Topics: Acidosis, Lactic; Acute Kidney Injury; Diabetes Mellitus, Type 2; Fatal Outcome; Female; Forensic To | 2007 |
[Metformin-associated lactic acidosis and acute renal failure secondary to cardiac catheterism].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged, 80 and over; Cardiac Catheterization; Humans; Hypoglyce | 2007 |
Lactate levels in Asian patients with type 2 diabetes mellitus on metformin and its association with dose of metformin and renal function.
Topics: Acidosis, Lactic; Asia; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; | 2007 |
[Overdose of metformin secondary to acute renal insufficiency: a report of six cases].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic | 2007 |
[Classic drug in diabetes therapy. Revise contraindications?].
Topics: Acidosis, Lactic; Adult; Child; Contraindications; Diabetes Mellitus, Type 1; Diabetes Mellitus, Typ | 2007 |
Metformin-associated lactic acidosis in patients with renal impairment solely due to drug accumulation?
Topics: Acidosis, Lactic; Aged; Diabetic Nephropathies; Female; Humans; Hypoglycemic Agents; Male; Metformin | 2008 |
Metformin-associated lactic acidosis following contrast media-induced nephrotoxicity.
Topics: Acidosis, Lactic; Angiography, Digital Subtraction; Blood Gas Analysis; Contrast Media; Diabetes Mel | 2008 |
Metformin-induced lactic acidosis and acute pancreatitis precipitated by diuretic, celecoxib, and candesartan-associated acute kidney dysfunction.
Topics: Acidosis, Lactic; Acute Disease; Acute Kidney Injury; Angiotensin II Type 1 Receptor Blockers; Benzi | 2008 |
Metformin overdose with a resultant serum pH of 6.59: survival without sequalae.
Topics: Acidosis, Lactic; Adult; Drug Overdose; Female; Humans; Hypoglycemic Agents; Hypotension; Metformin; | 2010 |
Metformin-associated lactic acidosis in type 2 diabetes mellitus: incidence and presentation in common clinical practice.
Topics: Acidosis, Lactic; Aged; Contraindications; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic A | 2008 |
Prevalence of risk determinants for metformin-associated lactic acidosis and metformin utilization in the study of health in pomerania.
Topics: Acidosis, Lactic; Adult; Aged; Algorithms; Diabetes Mellitus, Type 2; Female; Germany; Health; Human | 2008 |
Metformin and lactic acidosis in an Australian community setting: the Fremantle Diabetes Study.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Dose-Response Relations | 2008 |
[Metformin should not be used by patients with reduced renal function].
Topics: Acidosis, Lactic; Acute Kidney Injury; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Ag | 2008 |
Metformin-associated lactic acidosis in a pregnant patient.
Topics: Acidosis, Lactic; Adult; Birth Weight; Charcoal; Female; Humans; Hypoglycemic Agents; Infant, Newbor | 2008 |
New contraindication to intravascular iodinated contrast material.
Topics: Acidosis, Lactic; Acute Kidney Injury; Contraindications; Contrast Media; Diabetes Mellitus, Type 2; | 1995 |
New contraindication to intravascular iodinated contrast material.
Topics: Acidosis, Lactic; Acute Kidney Injury; Contraindications; Contrast Media; Diabetes Mellitus, Type 2; | 1995 |
Role of metformin accumulation in metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Aged; Analysis of Variance; Chromatography, High Pressure Liquid; Coma; Creatinine | 1995 |
[Metformin in patients with coronary disease?].
Topics: Acidosis, Lactic; Contraindications; Coronary Disease; Humans; Lactates; Lactic Acid; Metformin; Ris | 1995 |
Fatal metformin induced lactic acidosis: case report.
Topics: Acidosis, Lactic; Fatal Outcome; Female; Humans; Kidney Neoplasms; Metformin; Middle Aged; Postopera | 1995 |
Metformin for non-insulin-dependent diabetes mellitus.
Topics: Acidosis, Lactic; Clinical Trials as Topic; Combined Modality Therapy; Diabetes Mellitus, Type 2; Dr | 1995 |
[Withdraw metformin prior to contrast radiography. A warning in the Fass was forgotten, two patients died].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Angiography; Anuria; Catalogs, Drug as Topic; Contrast | 1995 |
Metformin-associated lactic acidosis in diabetic patients with acute renal failure.
Topics: Acidosis, Lactic; Acute Kidney Injury; Animals; Diabetes Mellitus, Type 2; Diabetic Nephropathies; G | 1995 |
Metformin-associated lactic acidosis in diabetic patients with acute renal failure. A critical analysis of its pathogenesis and prognosis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Eryt | 1994 |
Severe lactic acidosis in patient receiving continuous ambulatory peritoneal dialysis.
Topics: Acidosis, Lactic; Aged; Contraindications; Diabetes Mellitus, Type 2; Female; Humans; Kidney Failure | 1993 |
Metformin-associated lactic acidosis in Sweden 1977-1991.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Female; Humans; Male; Metformin; Middle Aged; Sweden; Tim | 1993 |
Efficacy of metformin in non-insulin-dependent diabetes mellitus.
Topics: Acidosis, Lactic; Aged; Contraindications; Diabetes Mellitus, Type 2; Fatal Outcome; Female; Humans; | 1996 |
Metformin and lactic acid acidosis.
Topics: Acidosis, Lactic; Drug Approval; Humans; Hypoglycemic Agents; Metformin; United States | 1996 |
Contrast-enhanced imaging studies contraindicated in patients receiving Glucophage.
Topics: Acidosis, Lactic; Contraindications; Contrast Media; Creatinine; Diabetes Mellitus; Drug Interaction | 1996 |
Hepatic necrosis after cardiac surgery.
Topics: Acidosis, Lactic; Anesthetics, Inhalation; Cardiac Surgical Procedures; Diabetes Mellitus; Enflurane | 1995 |
Metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Male; Metformin; Middle Ag | 1996 |
New contraindication to intravascular contrast material.
Topics: Acidosis, Lactic; Acute Kidney Injury; Contraindications; Contrast Media; Humans; Hypoglycemic Agent | 1996 |
Metformin: prevention of lactic acidosis.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin | 1996 |
Metformin-induced lactic acidosis associated with acute renal failure.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Arteriosclerosis; Blood Urea Nitrogen; Contrast Media; | 1996 |
Metformin-associated nonketotic metabolic acidosis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Diabetes Mellitus, Type 1; Humans; Hypoglycemic Agents; | 1997 |
Theophylline option for attenuating contrast media-induced nephrotoxicity in patients on metformin.
Topics: Acidosis, Lactic; Contraindications; Contrast Media; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 1997 |
Lactic acidosis associated with Glucophage use in a man with normal renal and hepatic function.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Drug Therapy, Combination; Human | 1997 |
Fatal hepatic necrosis following cardiac surgery and enflurane anaesthesia.
Topics: Acidosis, Lactic; Anesthesia, Inhalation; Anesthetics, Inhalation; Cardiac Surgical Procedures; Chem | 1996 |
Contraindications to metformin therapy in patients with NIDDM.
Topics: Acidosis, Lactic; Alcoholism; Contraindications; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; D | 1997 |
Bicarbonate haemodialysis as a treatment of metformin overdose.
Topics: Acidosis, Lactic; Adult; Bicarbonates; Buffers; Drug Overdose; Humans; Hypoglycemic Agents; Lactic A | 1997 |
Survival after metformin-associated lactic acidosis in peritoneal dialysis--dependent renal failure.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Kidney Failure, Ch | 1997 |
Metformin, contrast media, and theophylline.
Topics: Acidosis, Lactic; Contraindications; Contrast Media; Diabetes Mellitus, Type 2; Humans; Hypoglycemic | 1997 |
Lactic acidosis as a serious perioperative complication of antidiabetic biguanide medication with metformin.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Male; Metformin | 1997 |
Lactic acidosis in patients with diabetes treated with metformin.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Male; Metformin; Ris | 1998 |
Guidelines for performing angiography in patients taking metformin. Members of the Laboratory Performance Standards Committee of the Society for Cardiac Angiography and Interventions.
Topics: Acidosis, Lactic; Acute Kidney Injury; Angiography; Contrast Media; Humans; Hypoglycemic Agents; Iod | 1998 |
Clinical risk associated with contrast angiography in metformin treated patients: a clinical review.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Angiography; Contraindications; Contrast Media; Cr | 1998 |
Metformin and contrast media: where is the conflict?
Topics: Acidosis, Lactic; Contraindications; Contrast Media; Diabetes Mellitus, Type 2; Drug Interactions; H | 1998 |
Diabetics on Metformin.
Topics: Acidosis, Lactic; Contraindications; Contrast Media; Diabetes Mellitus; Humans; Hypoglycemic Agents; | 1998 |
Postoperative lactic acidosis in patients receiving metformin.
Topics: Acidosis, Lactic; Humans; Hypoglycemic Agents; Metformin; Postoperative Complications | 1998 |
Non-steroidal anti-inflammatory drugs and metformin: a cause for concern?
Topics: Acidosis, Lactic; Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Diabetes | 1998 |
Lactic acidosis with therapeutic metformin blood level in a low-risk diabetic patient.
Topics: Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glyburide; Hu | 1998 |
Lactic acidosis in metformin therapy. Relationship between plasma metformin concentration and renal function.
Topics: Acidosis, Lactic; Aged; Creatinine; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Male; Me | 1998 |
The management of metformin overdose.
Topics: Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Drug Overdose; Fatal Outcome; Female; Humans; Hy | 1998 |
Metformin and lactic acidosis: guilt by association?
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lactates; Liver; Metformin | 1998 |
Lactic acidosis rates in type 2 diabetes.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Incidence; M | 1998 |
Metformin hydrochloride all right before, but not after, contrast medium administration.
Topics: Acidosis, Lactic; Acute Kidney Injury; Contraindications; Contrast Media; Diabetes Mellitus, Type 2; | 1998 |
Keep metformin guidelines intact.
Topics: Acidosis, Lactic; Humans; Hypoglycemic Agents; Metformin; Practice Guidelines as Topic; United State | 1999 |
Lactic acidosis in metformin-treated patients. Prognostic value of arterial lactate levels and plasma metformin concentrations.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Female; Humans; Hydrogen-Ion Concentration; Hypogl | 1999 |
Lactic acidosis with therapeutic metformin blood level in a low-risk diabetic patient.
Topics: Acidosis, Lactic; Carbon Dioxide; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; | 1999 |
Contrast media and metformin: guidelines to diminish the risk of lactic acidosis in non-insulin-dependent diabetics after administration of contrast media. ESUR Contrast Media Safety Committee.
Topics: Acidosis, Lactic; Angiography; Contrast Media; Creatinine; Diabetes Mellitus, Type 2; Humans; Hypogl | 1999 |
Incidence of lactic acidosis in metformin users.
Topics: Acidosis, Lactic; Cohort Studies; Databases as Topic; Death Certificates; Humans; Hypoglycemic Agent | 1999 |
Metformin and lactic acidosis.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Registries; Uni | 1999 |
Lactic acidosis due to metformin.
Topics: Acidosis, Lactic; Contraindications; Humans; Hypoglycemic Agents; Metformin | 1999 |
Lactic acidosis in metformin therapy.
Topics: Acidosis, Lactic; Adult; Aged; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lactic Acid; | 1999 |
[Lactic acidosis feared adverse effect of metformin treatment. New guidelines can increase vigilance].
Topics: Acidosis, Lactic; Contraindications; Contrast Media; Diabetes Mellitus, Type 2; Guidelines as Topic; | 1999 |
[Hemodialysis cured severe lactic acidosis caused by metformin treatment].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Contraindications; Contrast Media; Diabetes Mellitus, T | 1999 |
Metformin and perioperative risk.
Topics: Acidosis, Lactic; Humans; Hypoglycemic Agents; Metformin; Postoperative Complications | 1999 |
Metformin and ageing diabetic patients.
Topics: Acidosis, Lactic; Aged; Aging; Diabetes Mellitus, Type 2; Health Services for the Aged; Humans; Hypo | 2000 |
Metformin in diabetes mellitus: are we choosing the right patients?
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Contraindications; Cross-Sectional Studies; Diabetes Mell | 2000 |
[Severe lactic acidosis due to metformin therapy in a patient with contra-indications for metformin].
Topics: Acidosis, Lactic; Alcoholic Intoxication; Contraindications; Diabetes Mellitus, Type 2; Fatal Outcom | 2000 |
Multicenter case series of pediatric metformin ingestion.
Topics: Acidosis, Lactic; Adolescent; Blood Glucose; Child; Child, Preschool; Drug Overdose; Female; Humans; | 2000 |
[Severe lactic acidosis due to metformin ingestion in a patient with contra-indication for metformin].
Topics: Acidosis, Lactic; Aged; Contraindications; Diabetes Mellitus, Type 2; Diagnosis, Differential; Femal | 2001 |
Metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Aged; Female; Humans; Hypoglycemic Agents; Metformin; Renal Dialysis | 2001 |
Use of urea containing dialysate to avoid disequilibrium syndrome, enabling intensive dialysis treatment of a diabetic patient with renal failure and severe metformin induced lactic acidosis.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Hypoglyce | 2001 |
[Metformin and anesthesia--how great is the risk of lactic acidosis].
Topics: Acidosis, Lactic; Anesthesia, General; Diabetes Mellitus, Type 2; Humans; Metformin; Risk Factors | 2001 |
[Metformin and contrast media--increased risk of lactic acidosis?].
Topics: Acidosis, Lactic; Contrast Media; Drug Synergism; Humans; Hypoglycemic Agents; Metformin; Norway; Pr | 2001 |
Metformin-associated lactic acidosis in a low risk patient.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Contraindications; Female; Humans; Hypoglycemic Agents; | 2001 |
[Metformin and anesthesia, how great is the risk of lactic acidosis?].
Topics: Acidosis, Lactic; Anesthesia, General; Humans; Hypoglycemic Agents; Metformin; Risk Factors | 2001 |
[Recommendations for perioperative interruption of metformin medication].
Topics: Acidosis, Lactic; Contraindications; Humans; Hypoglycemic Agents; Metformin; Perioperative Care; Phe | 2001 |
Metformin in non-alcoholic steatohepatitis.
Topics: Acidosis, Lactic; Fatty Liver; Follow-Up Studies; Humans; Liver Function Tests; Metformin; Risk Fact | 2002 |
Evaluation of prescribing practices: risk of lactic acidosis with metformin therapy.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Contraindications; Creatinine; Diabetes Mellitus, | 2002 |
Recovery from pH 6.38: lactic acidosis complicated by hypothermia.
Topics: Acidosis, Lactic; Humans; Hypoglycemic Agents; Hypothermia; Male; Metformin; Middle Aged; Prognosis | 2002 |
[Metformin-associated lactic acidosis with acute renal failure in type 2 diabetes mellitus].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Humans; K | 2002 |
Should intravenous contrast be used in patients receiving metformin.
Topics: Acidosis, Lactic; Contraindications; Contrast Media; Diabetes Mellitus, Type 2; Emergencies; Humans; | 2002 |
[Fatal lactic acidosis due to metformin in a male with type 2 diabetes mellitus and dehydration. Comments about a patient information leaflet].
Topics: Acidosis, Lactic; Aged; Dehydration; Diabetes Mellitus, Type 2; Drug Labeling; Emergencies; Humans; | 2002 |
Biguanide related lactic acidosis: incidence and risk factors.
Topics: Acidosis, Lactic; Adolescent; Adult; Aged; Aged, 80 and over; Biguanides; Contraindications; Diabete | 1992 |
Metformin-induced lactic acidosis: report of a case.
Topics: Acidosis, Lactic; Humans; Male; Metformin; Middle Aged | 1992 |
[Glucophage and lactic acidosis].
Topics: Acidosis, Lactic; Aged; Female; Humans; Male; Metformin; Middle Aged; Sweden | 1991 |
[Microassay of plasma and erythrocyte metformin by high performance liquid chromatography].
Topics: Acidosis, Lactic; Chromatography, High Pressure Liquid; Diabetes Mellitus; Erythrocytes; Humans; Met | 1991 |
[Metformin-associated lactic acidosis].
Topics: Acidosis, Lactic; Humans; Metformin | 1990 |
[Lactic acidosis in connection with metformin therapy].
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Humans; Metformin | 1990 |
[Lactic acidosis associated with metformin].
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Female; Humans; Male; Metformin; Middle Aged | 1990 |
Hemodialysis in the treatment of lactic acidosis in diabetics treated by metformin: a study of metformin elimination.
Topics: Acidosis, Lactic; Chromatography, Gas; Diabetic Ketoacidosis; Humans; Metformin; Renal Dialysis | 1989 |
Lactic acidosis due to metformin therapy in a low risk patient.
Topics: Acidosis, Lactic; Female; Humans; Metformin; Risk Factors | 1989 |
Bicarbonate haemodialysis: an adequate treatment for lactic acidosis in diabetics treated by metformin.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Bicarbonates; Diabetes Mellitus; Female; Humans; Male; Me | 1987 |
Recovery from metformin overdose.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Female; Humans; Metformin | 1985 |
[Lactic acidosis caused by metformin. Value of intraerythrocyte levels].
Topics: Acidosis, Lactic; Erythrocytes; Female; Humans; Metformin; Middle Aged | 1988 |
[Physiopathological approach to pathological hyperlactatemia in the diabetic patient. Value of blood metformin].
Topics: Acidosis, Lactic; Adult; Aged; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Female; Humans; Lac | 1987 |
Lactic acidosis due to metformin therapy in a low risk patient.
Topics: Acidosis, Lactic; Acute Kidney Injury; Chlorpropamide; Diabetes Mellitus, Type 2; Female; Humans; Me | 1988 |
Metformin and lactic acidosis--a reminder.
Topics: Acidosis, Lactic; Aged; Humans; Male; Metformin | 1987 |