Page last updated: 2024-10-30

metformin and Jaundice, Neonatal

metformin has been researched along with Jaundice, Neonatal in 3 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Jaundice, Neonatal: Yellow discoloration of the SKIN; MUCOUS MEMBRANE; and SCLERA in the NEWBORN. It is a sign of NEONATAL HYPERBILIRUBINEMIA. Most cases are transient self-limiting (PHYSIOLOGICAL NEONATAL JAUNDICE) occurring in the first week of life, but some can be a sign of pathological disorders, particularly LIVER DISEASES.

Research Excerpts

Excerpt	Relevance	Reference
"In a south Indian population with gestational diabetes, metformin was associated with better neonatal outcomes than glibenclamide."	2.80	Comparison of neonatal outcomes in women with gestational diabetes with moderate hyperglycaemia on metformin or glibenclamide--a randomised controlled trial. ( Abraham, A; Antonisamy, B; Beck, M; Benjamin, SJ; George, A; Jana, AK; Mathews, JE; Sam, D; Thomas, N, 2015)
"Metformin is a logical treatment for women with gestational diabetes mellitus, but randomized trials to assess the efficacy and safety of its use for this condition are lacking."	2.73	Metformin versus insulin for the treatment of gestational diabetes. ( Battin, MR; Gao, W; Hague, WM; Moore, MP; Rowan, JA, 2008)

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (66.67)	29.6817
2010's	1 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
George, A	1
Mathews, JE	1
Sam, D	1
Beck, M	1
Benjamin, SJ	1
Abraham, A	1
Antonisamy, B	1
Jana, AK	1
Thomas, N	1
Lundberg, GD	1
Rowan, JA	1
Hague, WM	1
Gao, W	1
Battin, MR	1
Moore, MP	1

Clinical Trials (6)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Glyburide and Metformin for the Treatment of Gestational Diabetes Mellitus. A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing These Drugs Either vs Insulin or vs Each Other.[NCT01998113]		2,509 participants (Actual)	Observational	2013-03-31	Completed
Does Metformin Improve Pregnancy Outcomes (Incidence of LGA (≥90% Birth Weight Centile) Babies, Onset of Maternal GDM, Hypertension, PET, Macrosomia, Shoulder Dystocia, Admission to SCBU) in Obese Non-diabetic Women?[NCT01273584]	Phase 2/Phase 3	450 participants (Actual)	Interventional	2010-10-31	Completed
Prevention of Pre-eclampsia Using Metformin: a Randomized Control Trial[NCT04855513]		414 participants (Anticipated)	Interventional	2022-03-24	Not yet recruiting
Effect of Metformin on Healthy Live Birth After In-vitro Fertilization in Women With Prediabetes Mellitus: a Multicenter Double-blind Placebo Controlled Randomized Trial[NCT06064669]		988 participants (Anticipated)	Interventional	2023-10-01	Not yet recruiting
Preventing Recurrent Gestational Diabetes Mellitus With Early Metformin Intervention[NCT02394158]	Phase 4	112 participants (Anticipated)	Interventional	2015-01-27	Recruiting
Non-inferiority Between Acarbose and Prandial Insulin for the Treatment of Gestational Diabetes Mellitus: a Randomized Multicenter and Prospective Trial. ACARB-GDM Study.[NCT03380546]	Phase 3	341 participants (Actual)	Interventional	2018-07-04	Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for metformin and Jaundice, Neonatal

Article	Year
Comparison of neonatal outcomes in women with gestational diabetes with moderate hyperglycaemia on metformin or glibenclamide--a randomised controlled trial. The Australian & New Zealand journal of obstetrics & gynaecology, 2015, Volume: 55, Issue:1 Topics: Adult; Birth Injuries; Birth Weight; Diabetes, Gestational; Female; Fetal Macrosomia; Glyburide; Hum	2015
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008
Metformin versus insulin for the treatment of gestational diabetes. The New England journal of medicine, 2008, May-08, Volume: 358, Issue:19 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008

Other Studies

1 other study available for metformin and Jaundice, Neonatal

Article	Year
Metformin Trumps insulin in the treatment of gestational diabetes. Medscape journal of medicine, 2008, Jul-31, Volume: 10, Issue:7 Topics: Adult; Diabetes, Gestational; Drug Therapy, Combination; Female; Gestational Age; Humans; Hypoglycem	2008