metformin has been researched along with Infertility in 9 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Infertility: A reduced or absent capacity to reproduce.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine if short courses of metformin (MET) administration in patients with polycystic ovary syndrome (PCOS) would reduce fasting insulin and improve the efficacy of clomiphene citrate (CC) to induce ovulation." | 9.12 | Two weeks of metformin improves clomiphene citrate-induced ovulation and metabolic profiles in women with polycystic ovary syndrome. ( Bonpane, CM; Helliwell, JP; Jaramillo, L; Katz, S; Khorram, O, 2006) |
| "To determine if short courses of metformin (MET) administration in patients with polycystic ovary syndrome (PCOS) would reduce fasting insulin and improve the efficacy of clomiphene citrate (CC) to induce ovulation." | 5.12 | Two weeks of metformin improves clomiphene citrate-induced ovulation and metabolic profiles in women with polycystic ovary syndrome. ( Bonpane, CM; Helliwell, JP; Jaramillo, L; Katz, S; Khorram, O, 2006) |
| "Metformin is a common treatment for women who have insulin resistance manifesting as type 2 diabetes or polycystic ovarian syndrome (PCOS)." | 4.82 | Metformin in obstetric and gynecologic practice: a review. ( Boyle, J; McCarthy, EA; McLachlan, K; Permezel, M; Walker, SP, 2004) |
| "This review provides an update on gestational diabetes (GDM) and other adverse pregnancy outcomes in individuals with polycystic ovary syndrome (PCOS), one of the most common metabolic disorders and causes of infertility." | 2.82 | Gestational diabetes and other adverse pregnancy outcomes in polycystic ovary syndrome. ( Powe, CE; Selen, DJ, 2022) |
| "Polycystic ovary syndrome is a diagnosis of exclusion of other causes of hyperandrogenism." | 2.43 | Polycystic ovary syndrome--a management update. ( Costello, MF, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 4 (44.44) | 2.80 |
| Authors | Studies |
|---|---|
| Smirnov, VV | 1 |
| Beeraka, NM | 1 |
| Butko, DY | 1 |
| Nikolenko, VN | 1 |
| Bondarev, SA | 1 |
| Achkasov, EE | 1 |
| Sinelnikov, MY | 1 |
| Vikram, PRH | 1 |
| Selen, DJ | 1 |
| Powe, CE | 1 |
| Cui, D | 1 |
| Xu, Z | 1 |
| Qiu, S | 1 |
| Sun, Y | 1 |
| Velazquez, C | 1 |
| Herrero, Y | 1 |
| Bianchi, MS | 1 |
| Cohen, DJ | 1 |
| Cuasnicu, P | 1 |
| Prost, K | 1 |
| Marinoni, R | 1 |
| Pascuali, N | 1 |
| Parborell, F | 1 |
| Abramovich, D | 1 |
| McCarthy, EA | 1 |
| Walker, SP | 1 |
| McLachlan, K | 1 |
| Boyle, J | 1 |
| Permezel, M | 1 |
| Costello, MF | 1 |
| Khorram, O | 1 |
| Helliwell, JP | 1 |
| Katz, S | 1 |
| Bonpane, CM | 1 |
| Jaramillo, L | 1 |
| Dunaif, A | 1 |
| Bromer, JG | 1 |
| Cetinkaya, MB | 1 |
| Arici, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Is the Co-administration of Metformine and CC as Compared to Placebo and CC Superior to Induce Ovulation in PCOS Patients With a Confirmed insulin-resistant-a Double Blind Randomized Clinical Trial[NCT02523898] | Phase 2 | 388 participants (Anticipated) | Interventional | 2015-11-30 | Enrolling by invitation | ||
| Effectiveness of the Combination Liraglutide and Metformin on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With Polycystic Ovarian Syndrome, Obesity and Infertility[NCT05952882] | Phase 3 | 188 participants (Anticipated) | Interventional | 2023-11-01 | Not yet recruiting | ||
| The Effect of Acupuncture on Insulin Sensitivity of Women With Polycystic Ovary Syndrome and Insulin Resistance: a Randomized Controlled Trial[NCT02491333] | Phase 3 | 342 participants (Actual) | Interventional | 2015-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for metformin and Infertility
| Article | Year |
|---|---|
Updates on Molecular Targets and Epigenetic-Based Therapies for PCOS.
Topics: Female; Humans; Hyperandrogenism; Infertility; Insulin Resistance; Metformin; Polycystic Ovary Syndr | 2023 |
Gestational diabetes and other adverse pregnancy outcomes in polycystic ovary syndrome.
Topics: Diabetes, Gestational; Female; Humans; Infertility; Metformin; Polycystic Ovary Syndrome; Pregnancy; | 2022 |
Metformin in obstetric and gynecologic practice: a review.
Topics: Abortion, Spontaneous; Anovulation; Diabetes Mellitus, Type 2; Female; Gastrointestinal Tract; Human | 2004 |
Polycystic ovary syndrome--a management update.
Topics: Contraceptives, Oral; Family Practice; Female; Glucose Intolerance; Humans; Hypoglycemic Agents; Inf | 2005 |
Drug insight: insulin-sensitizing drugs in the treatment of polycystic ovary syndrome--a reappraisal.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Hyperandrogenism; Infertility; Insulin Resista | 2008 |
Drug insight: insulin-sensitizing drugs in the treatment of polycystic ovary syndrome--a reappraisal.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Hyperandrogenism; Infertility; Insulin Resista | 2008 |
Drug insight: insulin-sensitizing drugs in the treatment of polycystic ovary syndrome--a reappraisal.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Hyperandrogenism; Infertility; Insulin Resista | 2008 |
Drug insight: insulin-sensitizing drugs in the treatment of polycystic ovary syndrome--a reappraisal.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Hyperandrogenism; Infertility; Insulin Resista | 2008 |
Pretreatments before the induction of ovulation in assisted reproduction technologies: evidence-based medicine in 2007.
Topics: Adrenal Cortex Hormones; Aspirin; Contraceptives, Oral; Evidence-Based Medicine; Female; Fertilizati | 2008 |
1 trial available for metformin and Infertility
| Article | Year |
|---|---|
Two weeks of metformin improves clomiphene citrate-induced ovulation and metabolic profiles in women with polycystic ovary syndrome.
Topics: Adult; Clomiphene; Drug Administration Schedule; Drug Combinations; Female; Fertility Agents, Female | 2006 |
2 other studies available for metformin and Infertility
| Article | Year |
|---|---|
Nasturtium officinale L. and metformin alleviate the estradiol- induced polycystic ovary syndrome with synergistic effects through modulation of Bax/Bcl-2/p53/caspase-3 signaling pathway and anti-inflammatory and anti-oxidative effects.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; bcl-2-Associated X Protein; Caspase 3; Cytokines; E | 2022 |
Beneficial effects of metformin on mice female fertility after a high-fat diet intake.
Topics: Animals; Diet, High-Fat; Female; Fertility; Infertility; Metformin; Mice; Mice, Inbred C57BL; Overwe | 2023 |