metformin has been researched along with Infertility, Male in 12 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Infertility, Male: The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine the appropriate treatment of oligo-terato-asthenozoospermic patients with metabolic syndrome, 45 patients were treated with metformin for 6 months." | 9.15 | Metformin improves semen characteristics of oligo-terato-asthenozoospermic men with metabolic syndrome. ( De Leo, V; Morgante, G; Musacchio, MC; Orvieto, R; Piomboni, P; Tosti, C, 2011) |
| "To examine the appropriate treatment of oligo-terato-asthenozoospermic patients with metabolic syndrome, 45 patients were treated with metformin for 6 months." | 5.15 | Metformin improves semen characteristics of oligo-terato-asthenozoospermic men with metabolic syndrome. ( De Leo, V; Morgante, G; Musacchio, MC; Orvieto, R; Piomboni, P; Tosti, C, 2011) |
| "Male infertility has been increasing over the last decades being nowadays a pressing health problem." | 2.52 | Impact of Metformin on Male Reproduction. ( Alves, MG; Ferreira, C; Oliveira, PF; Rabaça, A; Sá, R; Sousa, M, 2015) |
| "Oxandrolone is a synthetic testosterone analog that is widely used among bodybuilders and athletes." | 1.72 | The Protective Effect of Metformin against Oxandrolone-Induced Infertility in Male Rats. ( Abed, AF; Al-Ameer, HJ; Al-Awaida, W; Jarrar, YB; Lee, SJ, 2022) |
| "Metformin is a drug used for the treatment of type 2 diabetes and disorders associated with insulin resistance." | 1.62 | ( Acloque, H; Bertoldo, MJ; Chevaleyre, C; Dupont, J; Faure, MC; Fournier, I; Froment, P; Guerquin, MJ; Khoueiry, R; Quanico, J; Ramé, C; Salzet, M, 2021) |
| "Obesity is a significant global health and socio-economic challenge, and considered an important risk factor for poor health outcomes including male reproductive dysfunction and infertility." | 1.62 | The effect of Nigella sativa oil and metformin on male seminal parameters and testosterone in Wistar rats exposed to an obesogenic diet. ( Almaghrawi, W; Henkel, R; Leisegang, K, 2021) |
| "Metformin has long been used for glycemic control in diabetic state." | 1.51 | Down-regulation of steroidogenesis-related genes and its accompanying fertility decline in streptozotocin-induced diabetic male rats: ameliorative effect of metformin. ( Ahmad, A; Bakar, ABA; Mohamed, M; Nna, VU, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 6 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Faure, MC | 1 |
| Khoueiry, R | 1 |
| Quanico, J | 1 |
| Acloque, H | 1 |
| Guerquin, MJ | 1 |
| Bertoldo, MJ | 1 |
| Chevaleyre, C | 1 |
| Ramé, C | 1 |
| Fournier, I | 1 |
| Salzet, M | 1 |
| Dupont, J | 1 |
| Froment, P | 1 |
| Nna, VU | 2 |
| Bakar, ABA | 2 |
| Ahmad, A | 2 |
| Umar, UZ | 1 |
| Suleiman, JB | 1 |
| Zakaria, Z | 1 |
| Othman, ZA | 1 |
| Mohamed, M | 2 |
| Al-Shathly, MR | 1 |
| Ali, SS | 1 |
| Ayuob, NN | 1 |
| Abed, AF | 1 |
| Jarrar, YB | 1 |
| Al-Ameer, HJ | 1 |
| Al-Awaida, W | 1 |
| Lee, SJ | 1 |
| Leisegang, K | 1 |
| Almaghrawi, W | 1 |
| Henkel, R | 1 |
| Alam, F | 1 |
| Farooqui, N | 1 |
| Rehman, R | 1 |
| La Vignera, S | 1 |
| Condorelli, RA | 1 |
| Duca, Y | 1 |
| Cannarella, R | 1 |
| Giacone, F | 1 |
| Calogero, AE | 1 |
| Adaramoye, OA | 1 |
| Lawal, SO | 1 |
| Stokes, VJ | 1 |
| Anderson, RA | 1 |
| George, JT | 1 |
| Ferreira, C | 1 |
| Sousa, M | 1 |
| Rabaça, A | 1 |
| Oliveira, PF | 1 |
| Alves, MG | 1 |
| Sá, R | 1 |
| Morgante, G | 1 |
| Tosti, C | 1 |
| Orvieto, R | 1 |
| Musacchio, MC | 1 |
| Piomboni, P | 1 |
| De Leo, V | 1 |
1 review available for metformin and Infertility, Male
| Article | Year |
|---|---|
Impact of Metformin on Male Reproduction.
Topics: Animals; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Infertility, Male; Male; Metformin; | 2015 |
1 trial available for metformin and Infertility, Male
| Article | Year |
|---|---|
Metformin improves semen characteristics of oligo-terato-asthenozoospermic men with metabolic syndrome.
Topics: Adult; Androgens; Asthenozoospermia; Humans; Hypoglycemic Agents; Infertility, Male; Insulin Resista | 2011 |
10 other studies available for metformin and Infertility, Male
| Article | Year |
|---|---|
Topics: Animals; DNA Damage; DNA Methylation; DNA-Binding Proteins; Female; Hypoglycemic Agents; Infertility | 2021 |
Malaysian propolis and metformin mitigate subfertility in streptozotocin-induced diabetic male rats by targeting steroidogenesis, testicular lactate transport, spermatogenesis and mating behaviour.
Topics: Animals; Diabetes Mellitus, Experimental; Fertility; Infertility, Male; Lactic Acid; Male; Metformin | 2020 |
Zingiber officinale preserves testicular structure and the expression of androgen receptors and proliferating cell nuclear antigen in diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Humans; Hypoglyc | 2020 |
The Protective Effect of Metformin against Oxandrolone-Induced Infertility in Male Rats.
Topics: Animals; Humans; Infertility, Male; Male; Metformin; Oxandrolone; Rats; Testis; Testosterone | 2022 |
The effect of Nigella sativa oil and metformin on male seminal parameters and testosterone in Wistar rats exposed to an obesogenic diet.
Topics: Animals; Anti-Obesity Agents; Biomarkers; Disease Models, Animal; Fertility; Fertility Agents, Male; | 2021 |
Metformin, Oxidative Stress and Male Infertility: Way Forward.
Topics: Humans; Hypoglycemic Agents; Infertility, Male; Male; Metformin; Oxidative Stress | 2021 |
Down-regulation of steroidogenesis-related genes and its accompanying fertility decline in streptozotocin-induced diabetic male rats: ameliorative effect of metformin.
Topics: Animals; Cell Survival; Cholesterol Side-Chain Cleavage Enzyme; Diabetes Mellitus, Experimental; DNA | 2019 |
FSH treatment for normogonadotropic male infertility: a synergistic role for metformin?
Topics: Adult; Female; Follicle Stimulating Hormone; Humans; Hypoglycemic Agents; Infertility, Male; Male; M | 2019 |
Effect of kolaviron, a biflavonoid complex from Garcinia kola seeds, on the antioxidant, hormonal and spermatogenic indices of diabetic male rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; | 2014 |
How does obesity affect fertility in men - and what are the treatment options?
Topics: Adiposity; Androgens; Aromatase Inhibitors; Body Mass Index; Clomiphene; Erectile Dysfunction; Estro | 2015 |