metformin has been researched along with Infertility, Female in 229 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Infertility, Female: Diminished or absent ability of a female to achieve conception.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this long-term follow-up study, 160 overweight or obese infertility Chinese PCOS were randomized to exenatide or metformin treatment for 12 weeks." | 9.51 | Effect of metformin and exenatide on pregnancy rate and pregnancy outcomes in overweight or obese infertility PCOS women: long-term follow-up of an RCT. ( Li, R; Mai, T; Zhang, Y; Zheng, S, 2022) |
| "To investigate the adjuvant efficacy of metformin treatment to achieve pathological complete response (CR) in patients with endometrial complex hyperplasia (CH) and complex atypical hyperplasia (CAH), and secondarily, to evaluate their pregnancy outcomes after following assisted reproductive technology (ART)." | 9.51 | A Prospective Cohort Study of Metformin as an Adjuvant Therapy for Infertile Women With Endometrial Complex Hyperplasia/Complex Atypical Hyperplasia and Their Subsequent Assisted Reproductive Technology Outcomes. ( Kong, WY; Liu, ZA; Wu, X; Yan, L; Zhang, N; Zhao, XB, 2022) |
| "To evaluate the impact of metformin on in vitro fertilization (IVF) outcomes in overweight and obese women with polycystic ovary syndrome (PCOS)." | 9.30 | Impact of Metformin on IVF Outcomes in Overweight and Obese Women With Polycystic Ovary Syndrome: A Randomized Double-Blind Controlled Trial. ( Abbas, AM; Abdalmageed, OS; Abdelaleem, AA; Abdelmagied, AE; Ali, MK; Farghaly, TA, 2019) |
| "The purpose is a comparison of effectiveness of myo-inositol and metformin in infertile women with polycystic ovary syndrome (PCOS) treated with letrozole." | 9.30 | The effectiveness of inositol and metformin on infertile polycystic ovary syndrome women with resistant to letrozole. ( Bazarganipour, F; Kutenaee, MA; Pourghasem, S; Taghavi, SA, 2019) |
| " The potential impact of short-term preconception intervention with liraglutide on fertility potential in polycystic ovary syndrome (PCOS) has not been evaluated yet." | 9.27 | Liraglutide increases IVF pregnancy rates in obese PCOS women with poor response to first-line reproductive treatments: a pilot randomized study. ( Janez, A; Jensterle, M; Salamun, V; Vrtacnik Bokal, E, 2018) |
| "Although several clinical trials have compared the clinical efficacy of clomiphene citrate (CC) combined with metformin (MET) in the treatment of women with polycystic ovary syndrome (PCOS), the results are controversial." | 9.22 | Therapeutic efficacy of clomiphene citrate combined with metformin in patients with polycystic ovary syndrome. ( Chen, X; Diao, W; Feng, J; Lin, W; Ma, P; Zhou, H, 2022) |
| "The aim of this study was to perform a meta-analysis of randomized controlled trials (RCTs) to evaluate the role of metformin in improving the reproduction outcomes for non-obese, infertile women with polycystic ovary syndrome." | 9.22 | Does metformin improve reproduction outcomes for non-obese, infertile women with polycystic ovary syndrome? Meta-analysis and systematic review. ( Kheirelseid, EAH; Lewis, S; Magzoub, R; Perks, C, 2022) |
| "Using the terms "metformin" and "polycystic ovary syndrome," we conducted a search the PubMed, EMBASE, and Google Scholar databases." | 9.22 | The use of metformin in women with polycystic ovary syndrome: an updated review. ( Neto, FTL; Notaro, ALG, 2022) |
| "To examine the efficacy of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone among women with polycystic ovary syndrome (PCOS) resistant to clomifene citrate." | 9.22 | A randomized controlled trial of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone for clomifene-citrate-resistant polycystic ovary syndrome. ( Abdel Moety, G; Al Mohammady, M; El-khayat, W; Hamed, D, 2016) |
| "To assess the adjuvant effect of metformin and N-acetylcysteine (NAC) to clomiphene citrate (CC) in induction of ovulation in Polycystic Ovary Syndrome (PCOS) patients." | 9.20 | The adjuvant effect of metformin and N-acetylcysteine to clomiphene citrate in induction of ovulation in patients with Polycystic Ovary Syndrome. ( Abdelhafez, A; Bakry, A; Elsawah, H; Maged, AM; Mostafa, WA, 2015) |
| "Berberine and metformin treatments prior to IVF improved the pregnancy outcome by normalizing the clinical, endocrine and metabolic parameters in PCOS women." | 9.19 | The use of berberine for women with polycystic ovary syndrome undergoing IVF treatment. ( An, Y; Guan, Y; Liu, B; Lu, M; Sun, Z; Zhang, Y, 2014) |
| "To compare the ovulation and conception rates after the treatment with Clomiphene Citrate (CC) alone and in combination with metformin in infertile patients presented with polycystic ovarian syndrome (PCOS)." | 9.17 | Efficacy of combined metformin-clomiphene citrate in comparison with clomiphene citrate alone in infertile women with polycystic ovarian syndrome (PCOS). ( Alwan, Y; Ayaz, A; Farooq, MU, 2013) |
| "To compare the hormonal-metabolic profiles and reproductive outcomes between women receiving metformin plus letrozole and women undergoing bilateral ovarian drilling in clomiphene citrate (CC)-resistant women with polycystic ovary syndrome (PCOS)." | 9.17 | Efficacy of combined metformin-letrozole in comparison with bilateral ovarian drilling in clomiphene-resistant infertile women with polycystic ovarian syndrome. ( Abd Elgafor, I, 2013) |
| "The role of metformin in the treatment of infertility in women with polycystic ovary syndrome (PCOS) is still controversial." | 9.16 | Metformin improves pregnancy and live-birth rates in women with polycystic ovary syndrome (PCOS): a multicenter, double-blind, placebo-controlled randomized trial. ( Bloigu, R; Hippeläinen, M; Morin-Papunen, L; Perheentupa, A; Puukka, K; Rantala, AS; Ruokonen, A; Tapanainen, JS; Tiitinen, A; Tinkanen, H; Unkila-Kallio, L, 2012) |
| "To compare the efficacy of 1000 mg and 1700 mg of metformin on ovulation induction in polycystic ovary syndrome (PCOS) women." | 9.15 | Randomized controlled trial of different doses of metformin for ovulation induction in infertile women with polycystic ovary syndrome. ( Jultanmas, R; Leelaphiwat, S; Lertvikool, S; Satirapot, C; Sophonsritsuk, A; Weerakiet, S, 2011) |
| "To study the effect of metformin before and during assisted reproductive technology (ART) on the clinical pregnancy rate (CPR) in non-obese women with polycystic ovary syndrome (PCOS)." | 9.15 | Use of metformin before and during assisted reproductive technology in non-obese young infertile women with polycystic ovary syndrome: a prospective, randomized, double-blind, multi-centre study. ( Carlsen, SM; Haapaniemikouru, K; Holst-Larsen, T; Humaidan, P; Kjøtrød, SB; Mellembakken, J; Morin-Papunen, L; Rasmussen, PE; Sunde, A; Thurin-Kjellberg, A; von Düring, V, 2011) |
| "To evaluate the effects of metformin on the ovarian response to gonadotropins given for in vitro fertilization (IVF) programs in patients with polycystic ovary syndrome (PCOS) and reduced ovarian reserve." | 9.15 | Does metformin affect the ovarian response to gonadotropins for in vitro fertilization treatment in patients with polycystic ovary syndrome and reduced ovarian reserve? A randomized controlled trial. ( Cappiello, F; Di Cello, A; Falbo, A; Palomba, S; Tolino, A; Zullo, F, 2011) |
| "The aim of this study was to evaluate the effects of calcium-vitamin D and metformin on the menstrual cycle and ovulation in patients with polycystic ovary syndrome (PCOS)." | 9.14 | The effects of calcium-vitamin D and metformin on polycystic ovary syndrome: a pilot study. ( Haghollahi, F; Rashidi, B; Shariat, M; Zayerii, F, 2009) |
| "To compare hormone levels and clinical outcomes in patients with polycystic ovary syndrome (PCOS) after metformin therapy or laparoscopic ovarian diathermy (LOD) at 6 months follow-up." | 9.14 | Comparison of metformin treatment and laparoscopic ovarian diathermy in patients with polycystic ovary syndrome. ( Asgari, Z; Ashrafinia, M; Eslami, B; Hosseini, R; Moini, A, 2009) |
| "The purpose of this study was to compare the effectiveness of laparoscopic ovarian diathermy (LOD) vs clomiphene citrate (CC) plus metformin in infertile patients with CC-resistant polycystic ovary syndrome (PCOS)." | 9.14 | Laparoscopic ovarian diathermy vs clomiphene citrate plus metformin as second-line strategy for infertile anovulatory patients with polycystic ovary syndrome: a randomized controlled trial. ( Battista, L; Falbo, A; Orio, F; Palomba, S; Russo, T; Tolino, A; Venturella, R; Zullo, F, 2010) |
| "For women with BMI > 32 kg/m(2), clinical pregnancy and live birth rates were 22% (7/32) and 16% (5/32) with metformin, 15% (5/33) and 6% (2/33) with placebo." | 9.14 | PCOSMIC: a multi-centre randomized trial in women with PolyCystic Ovary Syndrome evaluating Metformin for Infertility with Clomiphene. ( Buckingham, KL; Falkiner, J; Farquhar, CM; Johnson, NP; Milsom, S; Okonkwo, QL; Singh, VP; Stewart, AW, 2010) |
| "To compare the efficacy of metformin and clomiphene citrate (CC) therapies for ovulation induction in anovulatory infertile women with polycystic ovary syndrome (PCOS)." | 9.14 | Comparison of metformin and clomiphene citrate therapy for induction of ovulation in the polycystic ovary syndrome. ( Api, M; Baran, S; Cetin, A; Goksedef, BP, 2010) |
| "To determine the effects of metformin treatment on serum androgen levels ahead of and during the IVF cycle in infertile polycystic ovary syndrome (PCOS) women." | 9.14 | Possible metformin effect on adrenal androgens during pretreatment and IVF cycle in women with polycystic ovary syndrome. ( Carlsen, SM; Kjøtrød, SB; Sunde, A; von Düring, V, 2009) |
| "To evaluate ovulation and pregnancy predictors in infertile polycystic ovary syndrome (PCOS) patients who received clomiphene citrate (CC) and metformin as first-line ovulation inductors." | 9.14 | Efficacy predictors for metformin and clomiphene citrate treatment in anovulatory infertile patients with polycystic ovary syndrome. ( Falbo, A; Orio, F; Palomba, S; Tolino, A; Zullo, F, 2009) |
| "To determine the effect of metformin pretreatment on in vitro maturation (IVM) in the patients with clomiphene citrate-resistant polycystic ovary syndrome." | 9.13 | Effect of metformin pretreatment on pregnancy outcome of in vitro matured oocytes retrieved from women with polycystic ovary syndrome. ( Cao, Y; Cong, L; Li, J; Wei, Z; Zhang, Z; Zhou, P, 2008) |
| "An RCT among newly diagnosed, therapy naive women with polycystic ovary syndrome (PCOS) showed no significant differences in ovulation rate, ongoing pregnancy rate or spontaneous abortion rate in favour of clomifene citrate plus metformin compared with clomifene citrate." | 9.13 | Does adding metformin to clomifene citrate lead to higher pregnancy rates in a subset of women with polycystic ovary syndrome? ( Bossuyt, PM; Korevaar, JC; Moll, E; van der Veen, F, 2008) |
| "Current data supporting the effectiveness of metformin as a fertility treatment for women with polycystic ovary syndrome have been misinterpreted." | 9.12 | No more surrogate end-points in randomised trials: the PCOSMIC trial protocol for women with polycystic ovary syndrome using metformin for infertility with clomiphene. ( Johnson, NP, 2006) |
| "To evaluate the effects of metformin and of clomiphene citrate (CC) on the ovarian blood perfusion and on perifollicular and peri-corpus luteum (CL) vascularity in anovulatory women with polycystic ovary syndrome (PCOS)." | 9.12 | Effects of metformin and clomiphene citrate on ovarian vascularity in patients with polycystic ovary syndrome. ( Falbo, A; Orio, F; Palomba, S; Russo, T; Tolino, A; Zullo, F, 2006) |
| "Metformin is better for ovulation induction than CC alone and equivalent for pregnancy achievement." | 9.12 | Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction and achievement of pregnancy in 154 women with polycystic ovary syndrome. ( Granger, L; Lavoie, HB; Neveu, N; St-Michel, P, 2007) |
| "Metformin appears to be an effective medicine to induce ovulation in women with polycystic ovary syndrome and insulin resistance." | 9.12 | Increase of multiple pregnancies caused by ovulation induction with gonadotropin in combination with metformin in infertile women with polycystic ovary syndrome. ( Hirano, Y; Kikuchi, K; Shibahara, H; Suzuki, M; Suzuki, T; Takamizawa, S, 2007) |
| "We randomly assigned 626 infertile women with the polycystic ovary syndrome to receive clomiphene citrate plus placebo, extended-release metformin plus placebo, or a combination of metformin and clomiphene for up to 6 months." | 9.12 | Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. ( Barnhart, HX; Carr, BR; Carson, SA; Cataldo, NA; Coutifaris, C; Diamond, MP; Giudice, LC; Gosman, GG; Legro, RS; Leppert, PC; McGovern, PG; Myers, ER; Nestler, JE; Schlaff, WD; Steinkampf, MP, 2007) |
| "The aim of the study was to compare in a clinical setting the efficacy of CC and metformin as first-line approaches for treating anovulation in infertile PCOS patients." | 9.12 | Clomiphene citrate versus metformin as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome. ( Falbo, A; Orio, F; Palomba, S; Russo, T; Tolino, A; Zullo, F, 2007) |
| "To evaluate the effects of metformin on insulin resistance, ovarian androgen production, and clomiphene-induced ovulation and pregnancy rates in infertile women with polycystic ovary syndrome (PCOS)." | 9.11 | The effects of metformin on insulin resistance, clomiphene-induced ovulation and pregnancy rates in women with polycystic ovary syndrome. ( Aygen, E; Keleştimur, F; Sahin, Y; Yirmibeş, U, 2004) |
| "To assess the effects of 6 months of metformin therapy on clinical and biochemical parameters in polycystic ovary syndrome (PCOS) and to evaluate those parameters in responders and nonresponders to identify the subjects who respond to an insulin sensitizer in PCOS." | 9.11 | Effects of metformin on clinical and biochemical parameters in polycystic ovary syndrome. ( Agarwal, N; Kriplani, A, 2004) |
| "To determine the clinical, biochemical, hormonal, and ultrasonographic effects of 6 months of metformin therapy in women with polycystic ovary syndrome (PCOS) and compare with pretherapy parameters." | 9.11 | Metformin therapy in women with polycystic ovary syndrome. ( Aruna, J; Dadhwal, V; Kumar, S; Misra, R; Mittal, S; Vimala, N, 2004) |
| "Metformin effectively restores insulin sensitivity in insulin-resistant women with polycystic ovary syndrome (PCOS)." | 9.10 | The effect of metformin on ovarian stimulation and in vitro fertilization in insulin-resistant women with polycystic ovary syndrome: an open-label randomized cross-over trial. ( Abyholm, T; Dale, PO; Fedorcsák, P; Storeng, R; Tanbo, T, 2003) |
| "To evaluate the effect of metformin therapy on hyperandrogenism, insulin resistance, cervical scores, ovulation, and pregnancy rates in clomiphene citrate-resistant women with polycystic ovary syndrome (PCOS)." | 9.10 | Metformin therapy improves ovulatory rates, cervical scores, and pregnancy rates in clomiphene citrate-resistant women with polycystic ovary syndrome. ( Caliskan, E; Haberal, A; Kocak, M; Simsir, C, 2002) |
| "To determine whether metformin pretreatment has beneficial effects in clomiphene resistant infertile women with polycystic ovary syndrome (PCOS) in an infertility clinic." | 9.10 | Metformin does not enhance ovulation induction in clomiphene resistant polycystic ovary syndrome in clinical practice. ( Fay, TN; Lannon, B; Sturrock, ND, 2002) |
| "To determine whether metformin treatment increases the ovulation and pregnancy rates in response to clomiphene citrate (CC) in women who are resistant to CC alone." | 9.09 | Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone. ( Evans, WS; Kauma, SW; Nestler, JE; Ratts, VS; Stovall, DW; Vandermolen, DT, 2001) |
| "Metformin alone compared with placebo increases the ovulation rate in women with polycystic ovary syndrome (PCOS) but should not be used as first-line therapy for anovulation because oral ovulation induction agents such as clomiphene citrate or letrozole alone are much more effective in increasing ovulation, pregnancy, and live-birth rates in women with PCOS." | 8.95 | Role of metformin for ovulation induction in infertile patients with polycystic ovary syndrome (PCOS): a guideline. ( , 2017) |
| " Insulin-sensitising agents such as metformin may be effective in treating PCOS-related anovulation." | 8.95 | Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. ( Balen, AH; Morley, LC; Norman, RJ; Tang, T; Yasmin, E, 2017) |
| " Metformin may increase the effectiveness of ovulation induction with gonadotrophins and may promote safety by preventing multiple pregnancy." | 8.95 | Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination for subfertility associated with polycystic ovary syndrome. ( Bordewijk, EM; Costello, MF; Mol, BW; Nahuis, M; Tso, LO; Van der Veen, F; van Wely, M, 2017) |
| "In women with polycystic ovary syndrome, metformin treatment before or during assisted reproductive technology cycles increases clinical pregnancy rates and decreases the risk of ovarian hyperstimulation syndrome." | 8.91 | Metformin treatment before and during in vitro fertilization or intracytoplasmic sperm injection in women with polycystic ovary syndrome: summary of a Cochrane review. ( Albuquerque, LE; Andriolo, RB; Costello, MF; Macedo, CR; Marjoribanks, J; Tso, LO, 2015) |
| "The current systematic review with meta-analysis of randomized controlled trials (RCTs) was aimed to evaluate the effects of metformin on reproductive outcomes in patients with polycystic ovary syndrome (PCOS) who receive gonadotropins for ovulation induction." | 8.90 | Metformin and gonadotropins for ovulation induction in patients with polycystic ovary syndrome: a systematic review with meta-analysis of randomized controlled trials. ( Falbo, A; La Sala, GB; Palomba, S, 2014) |
| "Metformin is widely used for treating women with polycystic ovary syndrome (PCOS), and many patients with PCOS who are infertile receive gonadotrophins while being treated with metformin." | 8.89 | Effects of metformin in women with polycystic ovary syndrome treated with gonadotrophins for in vitro fertilisation and intracytoplasmic sperm injection cycles: a systematic review and meta-analysis of randomised controlled trials. ( Falbo, A; La Sala, GB; Palomba, S, 2013) |
| "This article is a review of the literature assessing pregnancy outcomes and the effect of metformin treatment among women with polycystic ovary syndrome (PCOS)." | 8.88 | Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview. ( Awwad, JT; Ghazeeri, GS; Nassar, AH; Younes, Z, 2012) |
| "In agreement with the previous review, metformin was associated with improved clinical pregnancy but there was no evidence that metformin improves live birth rates whether it is used alone or in combination with clomiphene, or when compared with clomiphene." | 8.88 | Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. ( Balen, AH; Lord, JM; Norman, RJ; Tang, T; Yasmin, E, 2012) |
| "To evaluate the efficacy of metformin (MTF) in treatment of clomiphene (CC)-resistant patients with polycystic ovary syndrome (PCOS)." | 8.88 | [Therapeutic effect of metformin for clomiphene-resistant infertility patients with polycystic ovary syndrome: a systematic analysis]. ( Cheng, QF; Fan, XD; Ren, W; Wang, LL, 2012) |
| "There are differences in opinion as to whether metformin should play a role in the primary treatment of anovulatory infertility for women with polycystic ovary syndrome (PCOS)." | 8.87 | Metformin is a reasonable first-line treatment option for non-obese women with infertility related to anovulatory polycystic ovary syndrome--a meta-analysis of randomised trials. ( Johnson, N, 2011) |
| " metformin, or the combination of both drugs as first-line therapy in anovulatory polycystic ovary syndrome (PCOS) patients seeking pregnancy." | 8.85 | Clomiphene citrate, metformin or both as first-step approach in treating anovulatory infertility in patients with polycystic ovary syndrome (PCOS): a systematic review of head-to-head randomized controlled studies and meta-analysis. ( Nestler, JE; Orio, F; Palomba, S; Pasquali, R, 2009) |
| "To report a case of triplet pregnancy after metformin treatment only, in a woman with polycystic ovary syndrome (PCOS) and a family history of twin pregnancies." | 8.84 | Triplet pregnancy after metformin in a woman with polycystic ovary syndrome. ( Clapauch, R; Mattos, TM, 2008) |
| "Metformin is an insulin sensitizer currently used for treating type-2 diabetes mellitus and recently administered for inducing ovulatory menstrual cycles in oligo-amenorrhoeic patients with polycystic ovary syndrome (PCOS)." | 8.84 | Outlook: metformin use in infertile patients with polycystic ovary syndrome: an evidence-based overview. ( Oppedisano, R; Orio, F; Palomba, S; Tolino, A; Zullo, F, 2008) |
| "The aim of this literature search is to establish if metformin is efficacious when given to clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS) patients." | 8.83 | Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review. ( Kruger, TF; Nosarka, S; Siebert, TI; Steyn, DW, 2006) |
| "To review the effectiveness of metformin in restoring regular menstrual cycles and ovulation and achieving pregnancy in women with polycystic ovary syndrome (PCOS)." | 8.82 | A systematic review of the reproductive system effects of metformin in patients with polycystic ovary syndrome. ( Costello, MF; Eden, JA, 2003) |
| "The debate on metformin use in polycystic ovary syndrome (PCOS) has mainly focused on its treatment for infertility in ovulation induction and menstrual cyclicity." | 8.81 | Should patients with polycystic ovary syndrome be treated with metformin? Benefits of insulin sensitizing drugs in polycystic ovary syndrome--beyond ovulation induction. ( Oehninger, S; Stadtmauer, LA; Wong, BC, 2002) |
| "The aim of this study was to evaluate the risk of major birth defects and spontaneous abortion after metformin use during the first trimester of pregnancy." | 7.88 | Pregnancy outcome after first-trimester exposure to metformin: A prospective cohort study. ( Beck, E; Grupe, K; Schaefer, C; Scherneck, S; Schlinke, N; Weber-Schoendorfer, C, 2018) |
| "The study aim was to evaluate our personal experience regarding the use and the reproductive effect of metformin administration in a large population of infertile patients with polycystic ovary syndrome (PCOS) undergoing gonadotropins ovarian stimulation for in vitro fertilization (IVF)." | 7.78 | Metformin administration in patients with polycystic ovary syndrome who receive gonadotropins for in vitro fertilization cycles: 10-year experience in a large infertile population. ( Cappiello, F; Di Cello, A; Falbo, A; Morelli, M; Orio, F; Palomba, S; Russo, T; Tolino, A; Zullo, F, 2012) |
| "Metformin is a promising medication for the prevention or reduction of the incidence of GDM and pre-eclampsia in PCOS women." | 7.77 | Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study. ( Aboul Foutouh, I; Ashmawi, HS; Khattab, S; Mohsen, IA; Mohsen, MN; van der Veen, F; van Wely, M; Youssef, MA, 2011) |
| "Abstract Objective: To evaluate the effects of oral contraceptives and metformin on the outcome of in vitro maturation (IVM) in infertile women with polycystic ovary syndrome (PCOS)." | 7.76 | Effects of oral contraceptives and metformin on the outcome of in vitro maturation in infertile women with polycystic ovary syndrome. ( Huang, XF; Huang, YP; Lin, JJ; Yang, HY; Zhang, W; Zhao, JZ, 2010) |
| "This study evaluated the use of metformin as first line treatment for patients with polycystic ovary syndrome." | 7.74 | The use of metformin as first line treatment in polycystic ovary syndrome. ( Abbas, M; Gannon, M, 2008) |
| "To analyze pregnancy complications and outcome in patients with polycystic ovary syndrome (PCOS) treated with metformin." | 7.73 | Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin. ( Jackson, EM; Thatcher, SS, 2006) |
| "Women with polycystic ovary syndrome (PCOS) are increasingly being treated with metformin as an insulin sensitizing agent to reduce symptoms of hyperandrogenism and promote fertility." | 7.72 | Women with polycystic ovary syndrome (PCOS) often undergo protracted treatment with metformin and are disinclined to stop: indications for a change in licensing arrangements? ( Fleming, R; Muth, S; Norman, J; Sattar, N, 2004) |
| "The aim of this study was to assess the efficacy of metformin on induction of ovulation in Asian women with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS)." | 7.72 | Efficacy of metformin on ovulation induction in Asian women with polycystic ovary syndrome. ( Choktanasiri, W; Rojanasakul, A; Sophonsritsuk, A; Tingthanatikul, Y; Wansumrith, S; Weerakiet, S, 2004) |
| "We evaluated the fertility promoting effect of metformin in infertile patients with polycystic ovary syndrome." | 7.71 | Metformin improves ovulation and pregnancy rates in patients with polycystic ovary syndrome. ( Batukan, C; Baysal, B, 2001) |
| "To assess pregnancy outcome in anovulatory infertility patients diagnosed with polycystic ovary syndrome (PCOS) who were treated with metformin." | 7.71 | Pregnancies following use of metformin for ovulation induction in patients with polycystic ovary syndrome. ( Buster, JE; Carson, SA; Heard, MJ; Pierce, A, 2002) |
| " Metformin, a medication that improves insulin sensitivity and decreases serum insulin levels, restores menstrual cyclicity and ovulatory function and may improve fertility rates in women with PCOS." | 7.70 | Association of metformin and pregnancy in the polycystic ovary syndrome. A report of three cases. ( Neal, GS; Robinson, RD; Seale, FG, 2000) |
| "Treatment with metformin and NAC significantly increased ovulation and pregnancy rates in CC-resistant PCOS patients." | 6.84 | Comparison of metformin and N-acetyl cysteine, as an adjuvant to clomiphene citrate, in clomiphene-resistant women with polycystic ovary syndrome. ( Heidari, B; Nemati, M; Nemati, S; Taheri, AM, 2017) |
| "Metformin is a safe, cheap drug that can help in prevention of OHSS." | 6.72 | Use of metformin for prevention of ovarian hyperstimulation syndrome: a novel approach. ( Fotouh, IA; Khattab, S; Metwally, M; Moaz, M; Mohesn, IA, 2006) |
| "When metformin was compared with CC, data for live birth were inconclusive, and the findings were limited by lack of evidence." | 6.61 | Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome. ( Balen, AH; Morley, LC; Norman, RJ; Sharpe, A; Tang, T, 2019) |
| "Metformin has been introduced as a therapeutic option in PCOS, targeting of cardiometabolic and reproductive abnormalities on the basis of its action on the reduction of glucose levels and the attenuation of insulin resistance." | 6.46 | Metformin in polycystic ovary syndrome. ( Christakou, C; Diamanti-Kandarakis, E; Economou, F; Palimeri, S, 2010) |
| "Insulin resistance is an important pathophysiological feature of the polycystic ovary syndrome (PCOS)." | 6.43 | Is metformin a primary ovulatory agent in patients with polycystic ovary syndrome? ( Cheang, KI; Nestler, JE; Sharma, ST, 2006) |
| "Polycystic ovary syndrome is a frequent endocrine disorder often associated with insulin resistance and hyperinsulinaemia which may play a role in hyperandrogenism and anovulation." | 6.42 | [Should infertile women with polycystic ovarian syndrome be treated with metformine?]. ( Basille, C; Bry-Gauillard, H; Cédrin-Durnerin, I; Galey, J; Hugues, JN; Massin, N; Théron-Gérard, L, 2003) |
| "Metformin has been reported to inhibit the growth of ectopic lesions in endometriosis." | 5.72 | Comparative Proteomic Analysis Reveals Metformin Improves the Expression of Biomarkers of Endometrial Receptivity in Infertile Women with Minimal/Mild Endometriosis. ( Huang, W; Huang, X; Li, Y; Liao, T; Long, Y; Luo, B; Ouyang, Y; Pei, T; Xiao, L; Zhu, H, 2022) |
| " This study aimed to investigate the effect of letrozole and metformin combined with targeted nursing on ovarian function, LH, and FSH in infertile patients with PCOS." | 5.72 | The Effects of Letrozole and Metformin Combined with Targeted Nursing Care on Ovarian Function, LH, and FSH in Infertile Patients with Polycystic Ovary Syndrome. ( Jiang, S; Li, R; Sheng, Y; Tang, T; Xu, H, 2022) |
| "In this long-term follow-up study, 160 overweight or obese infertility Chinese PCOS were randomized to exenatide or metformin treatment for 12 weeks." | 5.51 | Effect of metformin and exenatide on pregnancy rate and pregnancy outcomes in overweight or obese infertility PCOS women: long-term follow-up of an RCT. ( Li, R; Mai, T; Zhang, Y; Zheng, S, 2022) |
| "To investigate the adjuvant efficacy of metformin treatment to achieve pathological complete response (CR) in patients with endometrial complex hyperplasia (CH) and complex atypical hyperplasia (CAH), and secondarily, to evaluate their pregnancy outcomes after following assisted reproductive technology (ART)." | 5.51 | A Prospective Cohort Study of Metformin as an Adjuvant Therapy for Infertile Women With Endometrial Complex Hyperplasia/Complex Atypical Hyperplasia and Their Subsequent Assisted Reproductive Technology Outcomes. ( Kong, WY; Liu, ZA; Wu, X; Yan, L; Zhang, N; Zhao, XB, 2022) |
| "Letrozole-treated patients required a significantly lower amount of gonadotropins units (p < 0." | 5.48 | Mild ovarian stimulation with letrozole plus fixed dose human menopausal gonadotropin prior to IVF/ICSI for infertile non-obese women with polycystic ovarian syndrome being pre-treated with metformin: a pilot study. ( Cantatore, C; Caringella, AM; Caroppo, E; D'Amato, G; Palini, S; Stanziano, A, 2018) |
| "A total of 27 RCTs with 12 interventions were included, and all therapies tended to increase clinical pregnancy, especially pioglitazone (PIO) (log OR 3." | 5.41 | The effects of first-line pharmacological treatments for reproductive outcomes in infertile women with PCOS: a systematic review and network meta-analysis. ( Li, J; Liu, Y; Ma, J; Peng, G; Tong, N; Wang, Y; Yan, Z, 2023) |
| "To evaluate the benefits of myoinositol plus metformin versus myoinositol alone in infertile polycystic ovarian syndrome (PCOS) women undergoing ovulation induction cycles." | 5.41 | Impact of myoinositol with metformin and myoinositol alone in infertile PCOS women undergoing ovulation induction cycles - randomized controlled trial. ( Bhatla, N; Gupta, M; Kachhawa, G; Khadgawat, R; Kumari, R; Mahey, R; Prabhakar, P; Sharma, JB; Vanamail, P, 2021) |
| "To evaluate the impact of metformin on in vitro fertilization (IVF) outcomes in overweight and obese women with polycystic ovary syndrome (PCOS)." | 5.30 | Impact of Metformin on IVF Outcomes in Overweight and Obese Women With Polycystic Ovary Syndrome: A Randomized Double-Blind Controlled Trial. ( Abbas, AM; Abdalmageed, OS; Abdelaleem, AA; Abdelmagied, AE; Ali, MK; Farghaly, TA, 2019) |
| "To evaluate the reproductive and metabolic effects of L-carnitine plus metformin in clomiphene citrate (CC) resistant obese polycystic ovary syndrome (PCOS) women." | 5.30 | l-Carnitine plus metformin in clomiphene-resistant obese PCOS women, reproductive and metabolic effects: a randomized clinical trial. ( El Sharkwy, I; Sharaf El-Din, M, 2019) |
| "The purpose is a comparison of effectiveness of myo-inositol and metformin in infertile women with polycystic ovary syndrome (PCOS) treated with letrozole." | 5.30 | The effectiveness of inositol and metformin on infertile polycystic ovary syndrome women with resistant to letrozole. ( Bazarganipour, F; Kutenaee, MA; Pourghasem, S; Taghavi, SA, 2019) |
| " The potential impact of short-term preconception intervention with liraglutide on fertility potential in polycystic ovary syndrome (PCOS) has not been evaluated yet." | 5.27 | Liraglutide increases IVF pregnancy rates in obese PCOS women with poor response to first-line reproductive treatments: a pilot randomized study. ( Janez, A; Jensterle, M; Salamun, V; Vrtacnik Bokal, E, 2018) |
| "Although several clinical trials have compared the clinical efficacy of clomiphene citrate (CC) combined with metformin (MET) in the treatment of women with polycystic ovary syndrome (PCOS), the results are controversial." | 5.22 | Therapeutic efficacy of clomiphene citrate combined with metformin in patients with polycystic ovary syndrome. ( Chen, X; Diao, W; Feng, J; Lin, W; Ma, P; Zhou, H, 2022) |
| "The aim of this study was to perform a meta-analysis of randomized controlled trials (RCTs) to evaluate the role of metformin in improving the reproduction outcomes for non-obese, infertile women with polycystic ovary syndrome." | 5.22 | Does metformin improve reproduction outcomes for non-obese, infertile women with polycystic ovary syndrome? Meta-analysis and systematic review. ( Kheirelseid, EAH; Lewis, S; Magzoub, R; Perks, C, 2022) |
| "Using the terms "metformin" and "polycystic ovary syndrome," we conducted a search the PubMed, EMBASE, and Google Scholar databases." | 5.22 | The use of metformin in women with polycystic ovary syndrome: an updated review. ( Neto, FTL; Notaro, ALG, 2022) |
| "To examine the efficacy of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone among women with polycystic ovary syndrome (PCOS) resistant to clomifene citrate." | 5.22 | A randomized controlled trial of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone for clomifene-citrate-resistant polycystic ovary syndrome. ( Abdel Moety, G; Al Mohammady, M; El-khayat, W; Hamed, D, 2016) |
| "To assess the adjuvant effect of metformin and N-acetylcysteine (NAC) to clomiphene citrate (CC) in induction of ovulation in Polycystic Ovary Syndrome (PCOS) patients." | 5.20 | The adjuvant effect of metformin and N-acetylcysteine to clomiphene citrate in induction of ovulation in patients with Polycystic Ovary Syndrome. ( Abdelhafez, A; Bakry, A; Elsawah, H; Maged, AM; Mostafa, WA, 2015) |
| "Berberine and metformin treatments prior to IVF improved the pregnancy outcome by normalizing the clinical, endocrine and metabolic parameters in PCOS women." | 5.19 | The use of berberine for women with polycystic ovary syndrome undergoing IVF treatment. ( An, Y; Guan, Y; Liu, B; Lu, M; Sun, Z; Zhang, Y, 2014) |
| "To compare the ovulation and conception rates after the treatment with Clomiphene Citrate (CC) alone and in combination with metformin in infertile patients presented with polycystic ovarian syndrome (PCOS)." | 5.17 | Efficacy of combined metformin-clomiphene citrate in comparison with clomiphene citrate alone in infertile women with polycystic ovarian syndrome (PCOS). ( Alwan, Y; Ayaz, A; Farooq, MU, 2013) |
| "To compare the hormonal-metabolic profiles and reproductive outcomes between women receiving metformin plus letrozole and women undergoing bilateral ovarian drilling in clomiphene citrate (CC)-resistant women with polycystic ovary syndrome (PCOS)." | 5.17 | Efficacy of combined metformin-letrozole in comparison with bilateral ovarian drilling in clomiphene-resistant infertile women with polycystic ovarian syndrome. ( Abd Elgafor, I, 2013) |
| "The role of metformin in the treatment of infertility in women with polycystic ovary syndrome (PCOS) is still controversial." | 5.16 | Metformin improves pregnancy and live-birth rates in women with polycystic ovary syndrome (PCOS): a multicenter, double-blind, placebo-controlled randomized trial. ( Bloigu, R; Hippeläinen, M; Morin-Papunen, L; Perheentupa, A; Puukka, K; Rantala, AS; Ruokonen, A; Tapanainen, JS; Tiitinen, A; Tinkanen, H; Unkila-Kallio, L, 2012) |
| "To compare the efficacy of 1000 mg and 1700 mg of metformin on ovulation induction in polycystic ovary syndrome (PCOS) women." | 5.15 | Randomized controlled trial of different doses of metformin for ovulation induction in infertile women with polycystic ovary syndrome. ( Jultanmas, R; Leelaphiwat, S; Lertvikool, S; Satirapot, C; Sophonsritsuk, A; Weerakiet, S, 2011) |
| "To study the effect of metformin before and during assisted reproductive technology (ART) on the clinical pregnancy rate (CPR) in non-obese women with polycystic ovary syndrome (PCOS)." | 5.15 | Use of metformin before and during assisted reproductive technology in non-obese young infertile women with polycystic ovary syndrome: a prospective, randomized, double-blind, multi-centre study. ( Carlsen, SM; Haapaniemikouru, K; Holst-Larsen, T; Humaidan, P; Kjøtrød, SB; Mellembakken, J; Morin-Papunen, L; Rasmussen, PE; Sunde, A; Thurin-Kjellberg, A; von Düring, V, 2011) |
| "To evaluate the effects of metformin on the ovarian response to gonadotropins given for in vitro fertilization (IVF) programs in patients with polycystic ovary syndrome (PCOS) and reduced ovarian reserve." | 5.15 | Does metformin affect the ovarian response to gonadotropins for in vitro fertilization treatment in patients with polycystic ovary syndrome and reduced ovarian reserve? A randomized controlled trial. ( Cappiello, F; Di Cello, A; Falbo, A; Palomba, S; Tolino, A; Zullo, F, 2011) |
| "The aim of this study was to evaluate the effects of calcium-vitamin D and metformin on the menstrual cycle and ovulation in patients with polycystic ovary syndrome (PCOS)." | 5.14 | The effects of calcium-vitamin D and metformin on polycystic ovary syndrome: a pilot study. ( Haghollahi, F; Rashidi, B; Shariat, M; Zayerii, F, 2009) |
| "To compare hormone levels and clinical outcomes in patients with polycystic ovary syndrome (PCOS) after metformin therapy or laparoscopic ovarian diathermy (LOD) at 6 months follow-up." | 5.14 | Comparison of metformin treatment and laparoscopic ovarian diathermy in patients with polycystic ovary syndrome. ( Asgari, Z; Ashrafinia, M; Eslami, B; Hosseini, R; Moini, A, 2009) |
| "The purpose of this study was to compare the effectiveness of laparoscopic ovarian diathermy (LOD) vs clomiphene citrate (CC) plus metformin in infertile patients with CC-resistant polycystic ovary syndrome (PCOS)." | 5.14 | Laparoscopic ovarian diathermy vs clomiphene citrate plus metformin as second-line strategy for infertile anovulatory patients with polycystic ovary syndrome: a randomized controlled trial. ( Battista, L; Falbo, A; Orio, F; Palomba, S; Russo, T; Tolino, A; Venturella, R; Zullo, F, 2010) |
| "The aim of this study was to compare the effectiveness of myo-inositol (MYO) and metformin, in monotherapy or in association with recombinant follicle stimulating hormone (r-FSH), in the treatment of menstrual irregularities, chronic anovulation, and female infertility in patients with polycystic ovary syndrome (PCOS)." | 5.14 | Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women. ( Benedetto, V; Raffone, E; Rizzo, P, 2010) |
| "For women with BMI > 32 kg/m(2), clinical pregnancy and live birth rates were 22% (7/32) and 16% (5/32) with metformin, 15% (5/33) and 6% (2/33) with placebo." | 5.14 | PCOSMIC: a multi-centre randomized trial in women with PolyCystic Ovary Syndrome evaluating Metformin for Infertility with Clomiphene. ( Buckingham, KL; Falkiner, J; Farquhar, CM; Johnson, NP; Milsom, S; Okonkwo, QL; Singh, VP; Stewart, AW, 2010) |
| "To compare the efficacy of metformin and clomiphene citrate (CC) therapies for ovulation induction in anovulatory infertile women with polycystic ovary syndrome (PCOS)." | 5.14 | Comparison of metformin and clomiphene citrate therapy for induction of ovulation in the polycystic ovary syndrome. ( Api, M; Baran, S; Cetin, A; Goksedef, BP, 2010) |
| "To determine the effects of metformin treatment on serum androgen levels ahead of and during the IVF cycle in infertile polycystic ovary syndrome (PCOS) women." | 5.14 | Possible metformin effect on adrenal androgens during pretreatment and IVF cycle in women with polycystic ovary syndrome. ( Carlsen, SM; Kjøtrød, SB; Sunde, A; von Düring, V, 2009) |
| "To evaluate ovulation and pregnancy predictors in infertile polycystic ovary syndrome (PCOS) patients who received clomiphene citrate (CC) and metformin as first-line ovulation inductors." | 5.14 | Efficacy predictors for metformin and clomiphene citrate treatment in anovulatory infertile patients with polycystic ovary syndrome. ( Falbo, A; Orio, F; Palomba, S; Tolino, A; Zullo, F, 2009) |
| "To determine the effect of metformin pretreatment on in vitro maturation (IVM) in the patients with clomiphene citrate-resistant polycystic ovary syndrome." | 5.13 | Effect of metformin pretreatment on pregnancy outcome of in vitro matured oocytes retrieved from women with polycystic ovary syndrome. ( Cao, Y; Cong, L; Li, J; Wei, Z; Zhang, Z; Zhou, P, 2008) |
| "We investigated whether poor adherence with metformin tablets may have contributed to the poor success rates seen in the metformin-containing arms of the Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial." | 5.13 | Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial. ( Barnhart, HX; Carr, BR; Carson, SA; Cataldo, NA; Coutifaris, C; Diamond, MP; Giudice, LC; Gosman, G; Legro, RS; Leppert, PC; McGovern, PG; Myers, ER; Nestler, JE; Schlaff, WD; Steinkampf, MP, 2008) |
| "An RCT among newly diagnosed, therapy naive women with polycystic ovary syndrome (PCOS) showed no significant differences in ovulation rate, ongoing pregnancy rate or spontaneous abortion rate in favour of clomifene citrate plus metformin compared with clomifene citrate." | 5.13 | Does adding metformin to clomifene citrate lead to higher pregnancy rates in a subset of women with polycystic ovary syndrome? ( Bossuyt, PM; Korevaar, JC; Moll, E; van der Veen, F, 2008) |
| "Adding metformin to clomiphene citrate in clomiphene-resistant polycystic ovary syndrome (PCOS) patients increases ovulatory response." | 5.12 | Efficacy of combined metformin-letrozole in comparison with metformin-clomiphene citrate in clomiphene-resistant infertile women with polycystic ovarian disease. ( Ansari, Sh; Bagheri, M; Sohrabvand, F, 2006) |
| "Current data supporting the effectiveness of metformin as a fertility treatment for women with polycystic ovary syndrome have been misinterpreted." | 5.12 | No more surrogate end-points in randomised trials: the PCOSMIC trial protocol for women with polycystic ovary syndrome using metformin for infertility with clomiphene. ( Johnson, NP, 2006) |
| "To evaluate the effects of metformin and of clomiphene citrate (CC) on the ovarian blood perfusion and on perifollicular and peri-corpus luteum (CL) vascularity in anovulatory women with polycystic ovary syndrome (PCOS)." | 5.12 | Effects of metformin and clomiphene citrate on ovarian vascularity in patients with polycystic ovary syndrome. ( Falbo, A; Orio, F; Palomba, S; Russo, T; Tolino, A; Zullo, F, 2006) |
| "Metformin is better for ovulation induction than CC alone and equivalent for pregnancy achievement." | 5.12 | Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction and achievement of pregnancy in 154 women with polycystic ovary syndrome. ( Granger, L; Lavoie, HB; Neveu, N; St-Michel, P, 2007) |
| "Metformin appears to be an effective medicine to induce ovulation in women with polycystic ovary syndrome and insulin resistance." | 5.12 | Increase of multiple pregnancies caused by ovulation induction with gonadotropin in combination with metformin in infertile women with polycystic ovary syndrome. ( Hirano, Y; Kikuchi, K; Shibahara, H; Suzuki, M; Suzuki, T; Takamizawa, S, 2007) |
| "We randomly assigned 626 infertile women with the polycystic ovary syndrome to receive clomiphene citrate plus placebo, extended-release metformin plus placebo, or a combination of metformin and clomiphene for up to 6 months." | 5.12 | Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. ( Barnhart, HX; Carr, BR; Carson, SA; Cataldo, NA; Coutifaris, C; Diamond, MP; Giudice, LC; Gosman, GG; Legro, RS; Leppert, PC; McGovern, PG; Myers, ER; Nestler, JE; Schlaff, WD; Steinkampf, MP, 2007) |
| "The aim of the study was to compare in a clinical setting the efficacy of CC and metformin as first-line approaches for treating anovulation in infertile PCOS patients." | 5.12 | Clomiphene citrate versus metformin as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome. ( Falbo, A; Orio, F; Palomba, S; Russo, T; Tolino, A; Zullo, F, 2007) |
| "To evaluate the effects of metformin on insulin resistance, ovarian androgen production, and clomiphene-induced ovulation and pregnancy rates in infertile women with polycystic ovary syndrome (PCOS)." | 5.11 | The effects of metformin on insulin resistance, clomiphene-induced ovulation and pregnancy rates in women with polycystic ovary syndrome. ( Aygen, E; Keleştimur, F; Sahin, Y; Yirmibeş, U, 2004) |
| "To assess the effects of 6 months of metformin therapy on clinical and biochemical parameters in polycystic ovary syndrome (PCOS) and to evaluate those parameters in responders and nonresponders to identify the subjects who respond to an insulin sensitizer in PCOS." | 5.11 | Effects of metformin on clinical and biochemical parameters in polycystic ovary syndrome. ( Agarwal, N; Kriplani, A, 2004) |
| "To determine the clinical, biochemical, hormonal, and ultrasonographic effects of 6 months of metformin therapy in women with polycystic ovary syndrome (PCOS) and compare with pretherapy parameters." | 5.11 | Metformin therapy in women with polycystic ovary syndrome. ( Aruna, J; Dadhwal, V; Kumar, S; Misra, R; Mittal, S; Vimala, N, 2004) |
| "Metformin effectively restores insulin sensitivity in insulin-resistant women with polycystic ovary syndrome (PCOS)." | 5.10 | The effect of metformin on ovarian stimulation and in vitro fertilization in insulin-resistant women with polycystic ovary syndrome: an open-label randomized cross-over trial. ( Abyholm, T; Dale, PO; Fedorcsák, P; Storeng, R; Tanbo, T, 2003) |
| " Further we tried to identify the preventive influence of metformin on development of ovarian hyperstimulation syndrome." | 5.10 | [Importance of sensitization of insulin receptors in the prevention of ovarian hyperstimulation syndrome]. ( Crha, I; Ventruba, P; Visnová, H; Záková, J, 2003) |
| "To evaluate the effect of metformin therapy on hyperandrogenism, insulin resistance, cervical scores, ovulation, and pregnancy rates in clomiphene citrate-resistant women with polycystic ovary syndrome (PCOS)." | 5.10 | Metformin therapy improves ovulatory rates, cervical scores, and pregnancy rates in clomiphene citrate-resistant women with polycystic ovary syndrome. ( Caliskan, E; Haberal, A; Kocak, M; Simsir, C, 2002) |
| "To determine whether metformin pretreatment has beneficial effects in clomiphene resistant infertile women with polycystic ovary syndrome (PCOS) in an infertility clinic." | 5.10 | Metformin does not enhance ovulation induction in clomiphene resistant polycystic ovary syndrome in clinical practice. ( Fay, TN; Lannon, B; Sturrock, ND, 2002) |
| "To determine whether metformin treatment increases the ovulation and pregnancy rates in response to clomiphene citrate (CC) in women who are resistant to CC alone." | 5.09 | Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone. ( Evans, WS; Kauma, SW; Nestler, JE; Ratts, VS; Stovall, DW; Vandermolen, DT, 2001) |
| "In women with PCOS, letrozole improves live birth and clinical pregnancy rates and reduces time-to-pregnancy compared to CC and therefore can be recommended as the preferred first-line treatment for women with PCOS and infertility." | 5.01 | First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis. ( Amer, SA; Bhattacharya, S; Bordewijk, EM; Falbo, A; Federica, G; Gao, J; Homburg, R; Huang, W; Johnson, NP; Kar, S; König, TE; Legro, RS; Li, W; Lord, J; Mol, BW; Moll, E; Morin-Papunen, L; Nazik, H; Norman, RJ; Özmen, Ü; Palomba, S; Sahin, Y; van Wely, M; Vegetti, W; Wang, R; Williams, CD; Wu, X; Zhang, H, 2019) |
| "Metformin alone compared with placebo increases the ovulation rate in women with polycystic ovary syndrome (PCOS) but should not be used as first-line therapy for anovulation because oral ovulation induction agents such as clomiphene citrate or letrozole alone are much more effective in increasing ovulation, pregnancy, and live-birth rates in women with PCOS." | 4.95 | Role of metformin for ovulation induction in infertile patients with polycystic ovary syndrome (PCOS): a guideline. ( , 2017) |
| " Insulin-sensitising agents such as metformin may be effective in treating PCOS-related anovulation." | 4.95 | Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. ( Balen, AH; Morley, LC; Norman, RJ; Tang, T; Yasmin, E, 2017) |
| " Metformin may increase the effectiveness of ovulation induction with gonadotrophins and may promote safety by preventing multiple pregnancy." | 4.95 | Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination for subfertility associated with polycystic ovary syndrome. ( Bordewijk, EM; Costello, MF; Mol, BW; Nahuis, M; Tso, LO; Van der Veen, F; van Wely, M, 2017) |
| "Randomised controlled trials comparing eight ovulation induction treatments in women with WHO group II anovulation: clomiphene, letrozole, metformin, clomiphene and metformin combined, tamoxifen, gonadotropins, laparoscopic ovarian drilling, and placebo or no treatment." | 4.95 | Treatment strategies for women with WHO group II anovulation: systematic review and network meta-analysis ( Bhattacharya, S; Costello, MF; Johnson, NP; Kim, BV; Legro, RS; Mol, BW; Ng, EH; Norman, RJ; van Wely, M; Wang, R; Zhang, H, 2017) |
| "The potential reproductive benefits of metformin, a drug endowed with the capacity to ameliorate insulin resistance in polycystic ovary syndrome (PCOS), has garnered much interest over the past 2 decades." | 4.93 | Twenty years of ovulation induction with metformin for PCOS; what is the best available evidence? ( Abu Hashim, H, 2016) |
| "In women with polycystic ovary syndrome, metformin treatment before or during assisted reproductive technology cycles increases clinical pregnancy rates and decreases the risk of ovarian hyperstimulation syndrome." | 4.91 | Metformin treatment before and during in vitro fertilization or intracytoplasmic sperm injection in women with polycystic ovary syndrome: summary of a Cochrane review. ( Albuquerque, LE; Andriolo, RB; Costello, MF; Macedo, CR; Marjoribanks, J; Tso, LO, 2015) |
| "The current systematic review with meta-analysis of randomized controlled trials (RCTs) was aimed to evaluate the effects of metformin on reproductive outcomes in patients with polycystic ovary syndrome (PCOS) who receive gonadotropins for ovulation induction." | 4.90 | Metformin and gonadotropins for ovulation induction in patients with polycystic ovary syndrome: a systematic review with meta-analysis of randomized controlled trials. ( Falbo, A; La Sala, GB; Palomba, S, 2014) |
| "Metformin is widely used for treating women with polycystic ovary syndrome (PCOS), and many patients with PCOS who are infertile receive gonadotrophins while being treated with metformin." | 4.89 | Effects of metformin in women with polycystic ovary syndrome treated with gonadotrophins for in vitro fertilisation and intracytoplasmic sperm injection cycles: a systematic review and meta-analysis of randomised controlled trials. ( Falbo, A; La Sala, GB; Palomba, S, 2013) |
| "This article is a review of the literature assessing pregnancy outcomes and the effect of metformin treatment among women with polycystic ovary syndrome (PCOS)." | 4.88 | Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview. ( Awwad, JT; Ghazeeri, GS; Nassar, AH; Younes, Z, 2012) |
| "In agreement with the previous review, metformin was associated with improved clinical pregnancy but there was no evidence that metformin improves live birth rates whether it is used alone or in combination with clomiphene, or when compared with clomiphene." | 4.88 | Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. ( Balen, AH; Lord, JM; Norman, RJ; Tang, T; Yasmin, E, 2012) |
| "To evaluate of metformin effectiveness of ovulation induction treatment in polycystic ovary syndrome (PCOS) women." | 4.88 | The effectiveness of metformin ovulation induction treatment in patients with PCOS: a systematic review and meta-analysis. ( Chang, S; Chen, S; Xiao, J; Zhang, C, 2012) |
| " Obese women suffering from polycystic ovary syndrome may be first offered metformin for 3-4 months before the addition of clomiphene." | 4.88 | [Treatment of infertility]. ( Koivunen, R; Morin-Papunen, L, 2012) |
| "Though widely used, there is uncertainty about the effectiveness and adverse effects of metformin and clomiphene citrate (CC) for infertility in polycystic ovary syndrome (PCOS)." | 4.88 | Status of clomiphene citrate and metformin for infertility in PCOS. ( Costello, MF; Hart, R; Melder, AM; Misso, ML; Norman, RJ; Rombauts, L; Teede, HJ; Wong, J, 2012) |
| " The Pregnancy in PCOS trial II will determine the safety and efficacy of clomiphene citrate compared to letrozole, in achieving live birth in infertile women with PCOS." | 4.88 | Reproductive impact of polycystic ovary syndrome. ( Legro, RS; Usadi, RS, 2012) |
| "To evaluate the efficacy of metformin (MTF) in treatment of clomiphene (CC)-resistant patients with polycystic ovary syndrome (PCOS)." | 4.88 | [Therapeutic effect of metformin for clomiphene-resistant infertility patients with polycystic ovary syndrome: a systematic analysis]. ( Cheng, QF; Fan, XD; Ren, W; Wang, LL, 2012) |
| "There are differences in opinion as to whether metformin should play a role in the primary treatment of anovulatory infertility for women with polycystic ovary syndrome (PCOS)." | 4.87 | Metformin is a reasonable first-line treatment option for non-obese women with infertility related to anovulatory polycystic ovary syndrome--a meta-analysis of randomised trials. ( Johnson, N, 2011) |
| " metformin, or the combination of both drugs as first-line therapy in anovulatory polycystic ovary syndrome (PCOS) patients seeking pregnancy." | 4.85 | Clomiphene citrate, metformin or both as first-step approach in treating anovulatory infertility in patients with polycystic ovary syndrome (PCOS): a systematic review of head-to-head randomized controlled studies and meta-analysis. ( Nestler, JE; Orio, F; Palomba, S; Pasquali, R, 2009) |
| "To report a case of triplet pregnancy after metformin treatment only, in a woman with polycystic ovary syndrome (PCOS) and a family history of twin pregnancies." | 4.84 | Triplet pregnancy after metformin in a woman with polycystic ovary syndrome. ( Clapauch, R; Mattos, TM, 2008) |
| "Metformin is an insulin sensitizer currently used for treating type-2 diabetes mellitus and recently administered for inducing ovulatory menstrual cycles in oligo-amenorrhoeic patients with polycystic ovary syndrome (PCOS)." | 4.84 | Outlook: metformin use in infertile patients with polycystic ovary syndrome: an evidence-based overview. ( Oppedisano, R; Orio, F; Palomba, S; Tolino, A; Zullo, F, 2008) |
| "The aim of this literature search is to establish if metformin is efficacious when given to clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS) patients." | 4.83 | Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review. ( Kruger, TF; Nosarka, S; Siebert, TI; Steyn, DW, 2006) |
| "To review the effectiveness of metformin in restoring regular menstrual cycles and ovulation and achieving pregnancy in women with polycystic ovary syndrome (PCOS)." | 4.82 | A systematic review of the reproductive system effects of metformin in patients with polycystic ovary syndrome. ( Costello, MF; Eden, JA, 2003) |
| "This paper is a systematic review of metformin versus clomiphene citrate (CC) in women with polycystic ovary syndrome (PCOS)." | 4.82 | Insulin-sensitizing agents as primary therapy for patients with polycystic ovarian syndrome. ( Kashyap, S; Rosenwaks, Z; Wells, GA, 2004) |
| "The debate on metformin use in polycystic ovary syndrome (PCOS) has mainly focused on its treatment for infertility in ovulation induction and menstrual cyclicity." | 4.81 | Should patients with polycystic ovary syndrome be treated with metformin? Benefits of insulin sensitizing drugs in polycystic ovary syndrome--beyond ovulation induction. ( Oehninger, S; Stadtmauer, LA; Wong, BC, 2002) |
| "Fifty NMRI mice (7-8 weeks old) were randomly divided into five groups, including non-PCOS, PCOS and PCOS groups treated with clomiphene citrate (18 mg/kg body weight for 2 days), metformin (50 mg/100 g body weight for 30 days) and flutamide (10 mg/kg body weight injection for 15 days)." | 4.12 | Metformin, clomiphene citrate and flutamide effects on oocyte ultrastructure status and quality in PCOS mouse model. ( Esmaeilnezhad, S; Ghasemian, F, 2022) |
| "To some extent, the use of metformin may improve endometrial receptivity and pregnancy outcomes of women with polycystic ovarian syndrome (PCOS) undergoing in vitro fertilization/intracytoplasmic sperm injection." | 3.91 | Metformin Regulates Key MicroRNAs to Improve Endometrial Receptivity Through Increasing Implantation Marker Gene Expression in Patients with PCOS Undergoing IVF/ICSI. ( Chang, ZY; Sun, YP; Wang, JY; Wu, L; Yang, QL; Yao, GD; Zhai, J, 2019) |
| "The aim of this study was to evaluate the risk of major birth defects and spontaneous abortion after metformin use during the first trimester of pregnancy." | 3.88 | Pregnancy outcome after first-trimester exposure to metformin: A prospective cohort study. ( Beck, E; Grupe, K; Schaefer, C; Scherneck, S; Schlinke, N; Weber-Schoendorfer, C, 2018) |
| "The combination of dimethylbiguanide and pioglitazone was more effective for the treatment of PCOS complicated with IR than simple pioglitazone; chronic inflammation occurrence was possibly one of reasons for insulin sensitivity reduction of patients with PCOS." | 3.80 | Treatment of polycystic ovarian syndrome with insulin resistance by insulin-sensitizer. ( Hu, L; Hu, MH; Shen, H; Tian, L; Wu, QF, 2014) |
| "The study aim was to evaluate our personal experience regarding the use and the reproductive effect of metformin administration in a large population of infertile patients with polycystic ovary syndrome (PCOS) undergoing gonadotropins ovarian stimulation for in vitro fertilization (IVF)." | 3.78 | Metformin administration in patients with polycystic ovary syndrome who receive gonadotropins for in vitro fertilization cycles: 10-year experience in a large infertile population. ( Cappiello, F; Di Cello, A; Falbo, A; Morelli, M; Orio, F; Palomba, S; Russo, T; Tolino, A; Zullo, F, 2012) |
| "Metformin is a promising medication for the prevention or reduction of the incidence of GDM and pre-eclampsia in PCOS women." | 3.77 | Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study. ( Aboul Foutouh, I; Ashmawi, HS; Khattab, S; Mohsen, IA; Mohsen, MN; van der Veen, F; van Wely, M; Youssef, MA, 2011) |
| "A high rate of GD or IGT already was observed in the first weeks of pregnancy in our cohort under metformin treatment." | 3.77 | Early onset and high prevalence of gestational diabetes in PCOS and insulin resistant women before and after assisted reproduction. ( Bals-Pratsch, M; Grosser, B; Ortmann, O; Seifarth, C; Seifert, B, 2011) |
| "Metformin has failed to gain wide acceptance as a first-line treatment option for women with anovulatory infertility related to polycystic ovary syndrome." | 3.77 | Analysis of factors predicting success of metformin and clomiphene treatment for women with infertility owing to PCOS-related ovulation dysfunction in a randomised controlled trial. ( Bontekoe, S; Johnson, NP; Stewart, AW, 2011) |
| "Abstract Objective: To evaluate the effects of oral contraceptives and metformin on the outcome of in vitro maturation (IVM) in infertile women with polycystic ovary syndrome (PCOS)." | 3.76 | Effects of oral contraceptives and metformin on the outcome of in vitro maturation in infertile women with polycystic ovary syndrome. ( Huang, XF; Huang, YP; Lin, JJ; Yang, HY; Zhang, W; Zhao, JZ, 2010) |
| "The pregnancy in polycystic ovary syndrome (PPCOS) study was a prospective, multi-center, randomized clinical trial comparing three ovulation induction regimens: clomiphene citrate (CC), metformin and the combination of the two." | 3.76 | Decision trees for identifying predictors of treatment effectiveness in clinical trials and its application to ovulation in a study of women with polycystic ovary syndrome. ( Brzyski, RG; Casson, PR; Chen, X; Christman, GM; Coutifaris, C; Diamond, MP; Eisenberg, E; Huang, H; Krawetz, SA; Legro, RS; Santoro, N; Schlaff, WD; Zhang, H; Zhang, J; Zhang, L, 2010) |
| "To evaluate the effect of metformin addition during ovarian hyperstimulation on cycle parameters and outcome of in vitro fertilization (IVF) treatment in polycystic ovary syndrome (PCOS) patients with a body mass index (BMI) <28 kg/m(2)." | 3.75 | Efficacy of metformin supplementation during ovarian stimulation of lean PCOS patients undergoing in vitro fertilization. ( Kahraman, S; Kumbak, B, 2009) |
| " There is no evidence-based schema for achieving pregnancy in women with PCOS, though lifestyle modification, clomiphene citrate, and metformin are the current front line therapies." | 3.74 | Pregnancy considerations in women with polycystic ovary syndrome. ( Legro, RS, 2007) |
| " In a university teaching hospital, a total of 38 patients with polycystic ovarian syndrome were treated by metformin before undergoing an IVM cycle." | 3.74 | Controlled natural cycle IVF: a novel approach for a dominant follicle during an in-vitro maturation cycle. ( Fanchin, R; Frydman, N; Frydman, R; Kadoch, IJ; Le Du, A, 2007) |
| "To compare the incidence of multiple gestation following treatment with clomiphene citrate (CC), metformin (MET) or gonadotropins in polycystic ovary syndrome (PCOS) patients undergoing ovulation induction." | 3.74 | Risk of multiple gestation after ovulation induction in polycystic ovary syndrome. ( Kraja, A; Odem, RR; Pauls, RN; Pinto, AB; Ratts, VS; Williams, DB, 2007) |
| "This study evaluated the use of metformin as first line treatment for patients with polycystic ovary syndrome." | 3.74 | The use of metformin as first line treatment in polycystic ovary syndrome. ( Abbas, M; Gannon, M, 2008) |
| "To analyze pregnancy complications and outcome in patients with polycystic ovary syndrome (PCOS) treated with metformin." | 3.73 | Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin. ( Jackson, EM; Thatcher, SS, 2006) |
| "Women with polycystic ovary syndrome (PCOS) are increasingly being treated with metformin as an insulin sensitizing agent to reduce symptoms of hyperandrogenism and promote fertility." | 3.72 | Women with polycystic ovary syndrome (PCOS) often undergo protracted treatment with metformin and are disinclined to stop: indications for a change in licensing arrangements? ( Fleming, R; Muth, S; Norman, J; Sattar, N, 2004) |
| "The aim of this study was to assess the efficacy of metformin on induction of ovulation in Asian women with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS)." | 3.72 | Efficacy of metformin on ovulation induction in Asian women with polycystic ovary syndrome. ( Choktanasiri, W; Rojanasakul, A; Sophonsritsuk, A; Tingthanatikul, Y; Wansumrith, S; Weerakiet, S, 2004) |
| "We evaluated the fertility promoting effect of metformin in infertile patients with polycystic ovary syndrome." | 3.71 | Metformin improves ovulation and pregnancy rates in patients with polycystic ovary syndrome. ( Batukan, C; Baysal, B, 2001) |
| "To assess pregnancy outcome in anovulatory infertility patients diagnosed with polycystic ovary syndrome (PCOS) who were treated with metformin." | 3.71 | Pregnancies following use of metformin for ovulation induction in patients with polycystic ovary syndrome. ( Buster, JE; Carson, SA; Heard, MJ; Pierce, A, 2002) |
| " Metformin, a medication that improves insulin sensitivity and decreases serum insulin levels, restores menstrual cyclicity and ovulatory function and may improve fertility rates in women with PCOS." | 3.70 | Association of metformin and pregnancy in the polycystic ovary syndrome. A report of three cases. ( Neal, GS; Robinson, RD; Seale, FG, 2000) |
| "Measures of thrombophilia, hypofibrinolysis, reproductive hormones, and androgenic steroids before and after metformin therapy." | 3.70 | Polycystic ovary syndrome, infertility, familial thrombophilia, familial hypofibrinolysis, recurrent loss of in vitro fertilized embryos, and miscarriage. ( Awadalla, SG; Cameron, D; Fontaine, RN; Glueck, CJ; Phillips, H; Wang, P, 2000) |
| "Treatment with metformin and NAC significantly increased ovulation and pregnancy rates in CC-resistant PCOS patients." | 2.84 | Comparison of metformin and N-acetyl cysteine, as an adjuvant to clomiphene citrate, in clomiphene-resistant women with polycystic ovary syndrome. ( Heidari, B; Nemati, M; Nemati, S; Taheri, AM, 2017) |
| "Metformin is a safe, cheap drug that can help in prevention of OHSS." | 2.72 | Use of metformin for prevention of ovarian hyperstimulation syndrome: a novel approach. ( Fotouh, IA; Khattab, S; Metwally, M; Moaz, M; Mohesn, IA, 2006) |
| "Obesity is responsible for an increased risk of sub-fecundity and infertility." | 2.66 | Obesity, Polycystic Ovary Syndrome, and Infertility: A New Avenue for GLP-1 Receptor Agonists. ( Cena, H; Chiovato, L; Nappi, RE, 2020) |
| "When metformin was compared with CC, data for live birth were inconclusive, and the findings were limited by lack of evidence." | 2.61 | Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome. ( Balen, AH; Morley, LC; Norman, RJ; Sharpe, A; Tang, T, 2019) |
| "Obesity is a known risk factor for infertility in women." | 2.52 | Medical and surgical interventions to improve outcomes in obese women planning for pregnancy. ( Bahadursingh, S; Ramsewak, S; Sharma, A; Teelucksingh, S, 2015) |
| "Polycystic ovary syndrome is recognized as the most common hormonal and metabolic disorder likely to affect women." | 2.52 | [Evidence-based therapy of polycystic ovarian syndrome]. ( Csenteri, OK; Gődény, S, 2015) |
| "Polycystic ovary syndrome is the most common hormonal and metabolic disorder likely to affect women." | 2.52 | [Prevention and treatment of the complications of polycystic ovarian syndrome--the significance of evidence-based, interdisciplinary management]. ( Csenteri, OK; Gődény, S, 2015) |
| "Obesity is also a feature of this syndrome and contributes to associated metabolic abnormalities." | 2.48 | Polycystic ovarian syndrome management options. ( Bates, GW; Propst, AM, 2012) |
| "Polycystic ovarian syndrome is the major cause of anovulation and is generally associated with obesity." | 2.48 | Evaluation and treatment of anovulatory and unexplained infertility. ( Bates, GW; Propst, AM, 2012) |
| "Metformin has been introduced as a therapeutic option in PCOS, targeting of cardiometabolic and reproductive abnormalities on the basis of its action on the reduction of glucose levels and the attenuation of insulin resistance." | 2.46 | Metformin in polycystic ovary syndrome. ( Christakou, C; Diamanti-Kandarakis, E; Economou, F; Palimeri, S, 2010) |
| "Polycystic ovarian syndrome is the commonest endocrine disorder of reproductive-age women." | 2.44 | Polycystic ovarian syndrome--prognosis and treatment outcomes. ( Hart, R, 2007) |
| "Hypogonadotropic anovulation is treated with exogenous gonadotropins, and little has changed in its management." | 2.43 | Ovulatory disorders and infertility. ( Urman, B; Yakin, K, 2006) |
| "Polycystic ovary syndrome is a multi-system endocrinopathy with long-term metabolic and cardiovascular health consequences." | 2.43 | Contemporary medical therapy for polycystic ovary syndrome. ( Domino, SE; Lanham, MS; Lebovic, DI, 2006) |
| "Insulin resistance is an important pathophysiological feature of the polycystic ovary syndrome (PCOS)." | 2.43 | Is metformin a primary ovulatory agent in patients with polycystic ovary syndrome? ( Cheang, KI; Nestler, JE; Sharma, ST, 2006) |
| "The mechanism of anovulation is uncertain but there is evidence that arrested antral follicle development is associated with the abnormal endocrine profile, in particular the interaction of insulin and LH on granulosa cell differentiation." | 2.43 | Infertility in polycystic ovary syndrome: focus on low-dose gonadotropin treatment. ( Franks, S; Gorry, A; White, DM, 2006) |
| "Metformin has been shown to reduce ovarian production, enhance ovulatory cycles and in some cases increase fertility." | 2.42 | [Insulin resistance and polycystic ovary syndrome]. ( Basille, C; Bernard, L; Chabbert-Buffet, N; Christin-Maître, S, 2003) |
| "Polycystic ovary syndrome is a frequent endocrine disorder often associated with insulin resistance and hyperinsulinaemia which may play a role in hyperandrogenism and anovulation." | 2.42 | [Should infertile women with polycystic ovarian syndrome be treated with metformine?]. ( Basille, C; Bry-Gauillard, H; Cédrin-Durnerin, I; Galey, J; Hugues, JN; Massin, N; Théron-Gérard, L, 2003) |
| "Women with severe insulin resistance are a unique subset of polycystic ovary syndrome." | 2.41 | Induction of ovulation in infertile women with hyperandrogenism and insulin resistance. ( Barbieri, RL, 2000) |
| "Metformin has been reported to inhibit the growth of ectopic lesions in endometriosis." | 1.72 | Comparative Proteomic Analysis Reveals Metformin Improves the Expression of Biomarkers of Endometrial Receptivity in Infertile Women with Minimal/Mild Endometriosis. ( Huang, W; Huang, X; Li, Y; Liao, T; Long, Y; Luo, B; Ouyang, Y; Pei, T; Xiao, L; Zhu, H, 2022) |
| " This study aimed to investigate the effect of letrozole and metformin combined with targeted nursing on ovarian function, LH, and FSH in infertile patients with PCOS." | 1.72 | The Effects of Letrozole and Metformin Combined with Targeted Nursing Care on Ovarian Function, LH, and FSH in Infertile Patients with Polycystic Ovary Syndrome. ( Jiang, S; Li, R; Sheng, Y; Tang, T; Xu, H, 2022) |
| "Metformin and insulin were used for therapy; the resulting changes to glycogen metabolism and embryo implantation were examined." | 1.62 | The Effects of Altered Endometrial Glucose Homeostasis on Embryo Implantation in Type 2 Diabetic Mice. ( Cui, ZH; Guo, WJ; Ma, YD; Nie, L; Wang, YC; Yuan, DZ; Yue, LM; Zhang, JH; Zhang, LX; Zhang, XQ; Zhao, D, 2021) |
| "Letrozole-treated patients required a significantly lower amount of gonadotropins units (p < 0." | 1.48 | Mild ovarian stimulation with letrozole plus fixed dose human menopausal gonadotropin prior to IVF/ICSI for infertile non-obese women with polycystic ovarian syndrome being pre-treated with metformin: a pilot study. ( Cantatore, C; Caringella, AM; Caroppo, E; D'Amato, G; Palini, S; Stanziano, A, 2018) |
| "Polycystic ovary syndrome is the most common endocrinopathy among reproductive-aged women in the United States, affecting approximately 7% of female patients." | 1.43 | Diagnosis and Treatment of Polycystic Ovary Syndrome. ( Mortada, R; Porter, S; Williams, T, 2016) |
| "To compare the incidence of gestational diabetes mellitus (GDM) in Iranian infertile women with polycystic ovary syndrome (PCOS) and women without PCOS after pregnancies resulting from either assisted reproductive technology (ART) or spontaneous as well as to determine the risk factors of GDM in PCOS women." | 1.40 | Gestational diabetes mellitus risk factors in women with polycystic ovary syndrome (PCOS). ( Arabipoor, A; Ashrafi, M; Hosseini, R; Nourbakhsh, F; Sheikhan, F; Zolfaghari, Z, 2014) |
| "For women in whom weight loss is not possible, or for lean women with PCOS, clomiphene citrate is an effective first-line method of ovulation induction." | 1.34 | Ovulation induction management of PCOS. ( Guzick, DS, 2007) |
| "Hirsutism is the manifestation of hyperandrogenemia in PCOS." | 1.32 | The treatment of polycystic ovary syndrome. ( Ajossa, S; Guerriero, S; Melis, GB; Orrù, M; Paoletti, AM, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.44) | 18.2507 |
| 2000's | 103 (44.98) | 29.6817 |
| 2010's | 104 (45.41) | 24.3611 |
| 2020's | 21 (9.17) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, W | 1 |
| Feng, J | 1 |
| Zhou, H | 1 |
| Chen, X | 2 |
| Diao, W | 1 |
| Ma, P | 1 |
| Huang, X | 1 |
| Xiao, L | 1 |
| Long, Y | 1 |
| Pei, T | 1 |
| Luo, B | 1 |
| Liao, T | 1 |
| Li, Y | 1 |
| Zhu, H | 1 |
| Ouyang, Y | 1 |
| Huang, W | 2 |
| Magzoub, R | 1 |
| Kheirelseid, EAH | 1 |
| Perks, C | 1 |
| Lewis, S | 1 |
| Notaro, ALG | 1 |
| Neto, FTL | 1 |
| Meun, C | 1 |
| Oostingh, E | 1 |
| Louwers, Y | 1 |
| Laven, J | 1 |
| Jiang, S | 1 |
| Tang, T | 5 |
| Sheng, Y | 1 |
| Li, R | 2 |
| Xu, H | 1 |
| Froment, P | 1 |
| Plotton, I | 1 |
| Giulivi, C | 1 |
| Fabre, S | 1 |
| Khoueiry, R | 1 |
| Mourad, NI | 1 |
| Horman, S | 1 |
| Ramé, C | 1 |
| Rouillon, C | 1 |
| Grandhaye, J | 1 |
| Bigot, Y | 1 |
| Chevaleyre, C | 1 |
| Le Guevel, R | 1 |
| Mallegol, P | 1 |
| Andriantsitohaina, R | 1 |
| Guerif, F | 1 |
| Tamburini, J | 1 |
| Viollet, B | 1 |
| Foretz, M | 1 |
| Dupont, J | 1 |
| Ghasemian, F | 1 |
| Esmaeilnezhad, S | 1 |
| Mai, T | 1 |
| Zheng, S | 1 |
| Zhang, Y | 2 |
| Kong, WY | 1 |
| Liu, ZA | 1 |
| Zhang, N | 1 |
| Wu, X | 2 |
| Zhao, XB | 1 |
| Yan, L | 1 |
| Peng, G | 1 |
| Yan, Z | 1 |
| Liu, Y | 1 |
| Li, J | 2 |
| Ma, J | 1 |
| Tong, N | 1 |
| Wang, Y | 1 |
| Wang, R | 2 |
| Li, W | 1 |
| Bordewijk, EM | 2 |
| Legro, RS | 14 |
| Zhang, H | 3 |
| Gao, J | 1 |
| Morin-Papunen, L | 4 |
| Homburg, R | 2 |
| König, TE | 1 |
| Moll, E | 3 |
| Kar, S | 1 |
| Johnson, NP | 5 |
| Amer, SA | 1 |
| Vegetti, W | 1 |
| Palomba, S | 18 |
| Falbo, A | 13 |
| Özmen, Ü | 1 |
| Nazik, H | 1 |
| Williams, CD | 1 |
| Federica, G | 1 |
| Lord, J | 1 |
| Sahin, Y | 2 |
| Bhattacharya, S | 2 |
| Norman, RJ | 10 |
| van Wely, M | 6 |
| Mol, BW | 3 |
| Sharpe, A | 1 |
| Morley, LC | 3 |
| Balen, AH | 8 |
| Kim, C | 1 |
| Younes, N | 1 |
| Temprosa, M | 1 |
| Edelstein, S | 1 |
| Goldberg, RB | 1 |
| Araneta, MG | 1 |
| Wallia, A | 1 |
| Brown, A | 1 |
| Darwin, C | 1 |
| Ibebuogu, U | 1 |
| Pi-Sunyer, X | 1 |
| Knowler, WC | 1 |
| Zhang, XQ | 2 |
| Zhao, D | 2 |
| Ma, YD | 2 |
| Wang, YC | 2 |
| Zhang, LX | 2 |
| Guo, WJ | 2 |
| Zhang, JH | 2 |
| Nie, L | 2 |
| Yue, LM | 2 |
| Kim, CH | 1 |
| Chon, SJ | 1 |
| Lee, SH | 1 |
| Cena, H | 1 |
| Chiovato, L | 1 |
| Nappi, RE | 1 |
| Mahey, R | 2 |
| Gupta, M | 2 |
| Bansiwal, R | 1 |
| Sethi, A | 1 |
| Prabhakar, P | 1 |
| Khadgawat, R | 1 |
| Kachhawa, G | 1 |
| Sharma, JB | 1 |
| Vanamail, P | 1 |
| Kumari, R | 1 |
| Bhatla, N | 1 |
| Cui, ZH | 1 |
| Yuan, DZ | 1 |
| Piltonen, TT | 1 |
| Giudice, LC | 4 |
| Li, X | 1 |
| Celotto, S | 1 |
| Pizzol, D | 1 |
| Gasevic, D | 1 |
| Ji, MM | 1 |
| Barnini, T | 1 |
| Solmi, M | 1 |
| Stubbs, B | 1 |
| Smith, L | 1 |
| López Sánchez, GF | 1 |
| Pesolillo, G | 1 |
| Yu, Z | 1 |
| Tzoulaki, I | 1 |
| Theodoratou, E | 1 |
| Ioannidis, JPA | 1 |
| Veronese, N | 1 |
| Demurtas, J | 1 |
| Taghavi, SA | 2 |
| Jahanfar, S | 1 |
| Bazarganipour, F | 2 |
| Nemati, M | 1 |
| Nemati, S | 1 |
| Taheri, AM | 1 |
| Heidari, B | 1 |
| Ibáñez, L | 1 |
| Del Río, L | 1 |
| Díaz, M | 1 |
| Sebastiani, G | 1 |
| Pozo, ÓJ | 1 |
| López-Bermejo, A | 1 |
| de Zegher, F | 1 |
| Morgante, G | 2 |
| Massaro, MG | 2 |
| Di Sabatino, A | 1 |
| Cappelli, V | 1 |
| De Leo, V | 2 |
| Yasmin, E | 2 |
| Abdalmageed, OS | 1 |
| Farghaly, TA | 1 |
| Abdelaleem, AA | 1 |
| Abdelmagied, AE | 1 |
| Ali, MK | 1 |
| Abbas, AM | 1 |
| Salamun, V | 1 |
| Jensterle, M | 1 |
| Janez, A | 1 |
| Vrtacnik Bokal, E | 1 |
| Scherneck, S | 1 |
| Schlinke, N | 1 |
| Beck, E | 1 |
| Grupe, K | 1 |
| Weber-Schoendorfer, C | 1 |
| Schaefer, C | 1 |
| Marciniak, A | 1 |
| Lejman-Larysz, K | 1 |
| Nawrocka-Rutkowska, J | 1 |
| Brodowska, A | 1 |
| Songin, D | 1 |
| D'Amato, G | 1 |
| Caringella, AM | 1 |
| Stanziano, A | 1 |
| Cantatore, C | 1 |
| Palini, S | 1 |
| Caroppo, E | 1 |
| Showell, MG | 1 |
| Mackenzie-Proctor, R | 1 |
| Jordan, V | 1 |
| Hodgson, R | 1 |
| Farquhar, C | 1 |
| Zhai, J | 1 |
| Yao, GD | 1 |
| Wang, JY | 1 |
| Yang, QL | 1 |
| Wu, L | 1 |
| Chang, ZY | 1 |
| Sun, YP | 1 |
| Huang, YL | 1 |
| Shen, J | 1 |
| El Sharkwy, I | 1 |
| Sharaf El-Din, M | 1 |
| Pourghasem, S | 1 |
| Kutenaee, MA | 1 |
| Sun, X | 1 |
| Zhang, D | 1 |
| Zhang, W | 2 |
| Tauchert, S | 2 |
| Ludwig, AK | 1 |
| Diedrich, K | 2 |
| Weiss, JM | 2 |
| Michael, AE | 1 |
| Glenn, C | 1 |
| Wood, PJ | 1 |
| Webb, RJ | 1 |
| Pellatt, L | 1 |
| Mason, HD | 1 |
| Banerjee, P | 1 |
| Bhonde, RR | 1 |
| Pal, R | 1 |
| An, Y | 1 |
| Sun, Z | 1 |
| Liu, B | 1 |
| Guan, Y | 1 |
| Lu, M | 1 |
| Ayaz, A | 1 |
| Alwan, Y | 1 |
| Farooq, MU | 1 |
| Musacchio, MC | 1 |
| Orvieto, R | 1 |
| Panidis, D | 1 |
| Tziomalos, K | 1 |
| Papadakis, E | 1 |
| Katsikis, I | 1 |
| La Sala, GB | 2 |
| Barthelmess, EK | 1 |
| Naz, RK | 1 |
| Leanza, V | 1 |
| Coco, L | 1 |
| Grasso, F | 1 |
| Leanza, G | 1 |
| Zarbo, G | 1 |
| Palumbo, M | 1 |
| Hu, L | 1 |
| Shen, H | 1 |
| Wu, QF | 1 |
| Tian, L | 1 |
| Hu, MH | 1 |
| Ashrafi, M | 1 |
| Sheikhan, F | 1 |
| Arabipoor, A | 1 |
| Hosseini, R | 2 |
| Nourbakhsh, F | 1 |
| Zolfaghari, Z | 1 |
| Cheraghi, E | 1 |
| Mehranjani, MS | 1 |
| Shariatzadeh, MA | 1 |
| Esfahani, MH | 1 |
| Ebrahimi, Z | 1 |
| Messinis, IE | 1 |
| Messini, CI | 1 |
| Anifandis, G | 1 |
| Dafopoulos, K | 1 |
| Nardo, LG | 1 |
| El-Toukhy, T | 1 |
| Stewart, J | 1 |
| Potdar, N | 1 |
| Fernandez, H | 2 |
| Cedrin-Durnerin, I | 2 |
| Gallot, V | 1 |
| Rongieres, C | 1 |
| Watrelot, A | 1 |
| Mayenga-Mankezi, JM | 1 |
| Arnoux, A | 1 |
| Sharma, A | 1 |
| Bahadursingh, S | 1 |
| Ramsewak, S | 1 |
| Teelucksingh, S | 1 |
| Spritzer, PM | 1 |
| Motta, AB | 1 |
| Sir-Petermann, T | 1 |
| Diamanti-Kandarakis, E | 4 |
| Tso, LO | 2 |
| Costello, MF | 6 |
| Albuquerque, LE | 1 |
| Andriolo, RB | 1 |
| Marjoribanks, J | 1 |
| Macedo, CR | 1 |
| Maged, AM | 1 |
| Elsawah, H | 1 |
| Abdelhafez, A | 1 |
| Bakry, A | 1 |
| Mostafa, WA | 1 |
| Gődény, S | 2 |
| Csenteri, OK | 2 |
| El-khayat, W | 1 |
| Abdel Moety, G | 1 |
| Al Mohammady, M | 1 |
| Hamed, D | 1 |
| Tannus, S | 1 |
| Burke, YZ | 1 |
| Kol, S | 1 |
| Abu Hashim, H | 2 |
| Birch Petersen, K | 1 |
| Pedersen, NG | 1 |
| Pedersen, AT | 1 |
| Lauritsen, MP | 1 |
| la Cour Freiesleben, N | 1 |
| Williams, T | 1 |
| Mortada, R | 1 |
| Porter, S | 1 |
| Misso, M | 1 |
| Franks, S | 2 |
| Wijeyaratne, CN | 1 |
| Stener-Victorin, E | 1 |
| Fauser, BC | 2 |
| Teede, H | 1 |
| Jacob, SL | 1 |
| Brewer, C | 1 |
| Picton, HM | 1 |
| Barth, JH | 1 |
| Nahuis, M | 1 |
| Van der Veen, F | 4 |
| Kim, BV | 1 |
| Ng, EH | 1 |
| Haas, J | 1 |
| Bentov, Y | 1 |
| Cui, N | 1 |
| Feng, X | 1 |
| Zhao, Z | 1 |
| Zhang, J | 2 |
| Xu, Y | 1 |
| Wang, L | 1 |
| Hao, G | 1 |
| Jakimiuk, AJ | 1 |
| Elizur, SE | 1 |
| Tulandi, T | 1 |
| Nestler, JE | 10 |
| Cocksedge, KA | 1 |
| Li, TC | 1 |
| Saravelos, SH | 1 |
| Metwally, M | 2 |
| Pasquali, R | 1 |
| Orio, F | 11 |
| Hart, R | 4 |
| Mathur, R | 1 |
| Alexander, CJ | 1 |
| Yano, J | 1 |
| Trivax, B | 1 |
| Azziz, R | 1 |
| Kumbak, B | 1 |
| Kahraman, S | 1 |
| Wisniewski, M | 1 |
| Petersen, M | 1 |
| Pagidas, K | 1 |
| Carson, SA | 6 |
| McGovern, PG | 5 |
| Barnhart, HX | 4 |
| Myers, ER | 5 |
| Diamond, MP | 6 |
| Carr, BR | 5 |
| Schlaff, WD | 6 |
| Coutifaris, C | 6 |
| Steinkampf, MP | 5 |
| Cataldo, NA | 5 |
| Gosman, G | 3 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Semaglutide Improves Metabolic Abnormalities and Fertility in Obese Infertile Women With Polycystic Ovary Syndrome: a Prospective, Randomized, Open, Controlled Study[NCT05702905] | Phase 4 | 75 participants (Anticipated) | Interventional | 2023-04-30 | Not yet recruiting | ||
| Effect of Metformin on Healthy Live Birth After In-vitro Fertilization in Women With Prediabetes Mellitus: a Multicenter Double-blind Placebo Controlled Randomized Trial[NCT06064669] | 988 participants (Anticipated) | Interventional | 2023-10-01 | Not yet recruiting | |||
| Abnormalities of the Endometrium Persist Despite Adequate Progesterone Supplementation in the Polycystic Ovary Syndrome[NCT05062135] | 36 participants (Actual) | Interventional | 2014-02-10 | Completed | |||
| Diabetes Prevention Program Outcomes Study[NCT00038727] | Phase 3 | 2,779 participants (Actual) | Interventional | 2002-09-30 | Active, not recruiting | ||
| Effectiveness of the Combination Liraglutide and Metformin on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With Polycystic Ovarian Syndrome, Obesity and Infertility[NCT05952882] | Phase 3 | 188 participants (Anticipated) | Interventional | 2023-11-01 | Not yet recruiting | ||
| Independent and Additive Effects Of Micronutrients With Metformin In Patients With PCOS:A Double Blind Randomized Placebo Controlled Trial[NCT05653895] | 250 participants (Anticipated) | Interventional | 2022-12-07 | Recruiting | |||
| The Effects of Acetyl L--Carnitine and Myo/Chiro-Inositol on Improving Ovulation, Pregnancy Rate, Ovarian Function and Perceived Stress Response in Patients With PCOS[NCT05767515] | 120 participants (Anticipated) | Interventional | 2023-04-15 | Not yet recruiting | |||
| Impact of Metformin on In Vitro Fertilization Outcomes in Overweight and Obese Polycystic Ovary Syndrome Women; A Quasi Experimental Study[NCT02910817] | 102 participants (Actual) | Interventional | 2015-01-31 | Completed | |||
| Randomized Clinical Trial to Evaluate The Effect of Metformin-GLP-1 Receptor Agonist Versus Oral Contraceptive (OC) Therapy on Reproductive Disorders and Cardiovascular Risks in Overweight Polycystic Ovarian Syndrome (PCOS) Patients[NCT03151005] | Phase 4 | 70 participants (Actual) | Interventional | 2017-07-01 | Completed | ||
| Is the Co-administration of Metformine and CC as Compared to Placebo and CC Superior to Induce Ovulation in PCOS Patients With a Confirmed insulin-resistant-a Double Blind Randomized Clinical Trial[NCT02523898] | Phase 2 | 388 participants (Anticipated) | Interventional | 2015-11-30 | Enrolling by invitation | ||
| Pregnancy in Polycystic Ovary Syndrome: A 30 Week Double-Blind Randomized Trial of Clomiphene Citrate, Metformin XR, and Combined Clomiphene Citrate/Metformin XR For the Treatment of Infertility in Women With Polycystic Ovary Syndrome[NCT00068861] | Phase 3 | 678 participants | Interventional | 2002-11-30 | Completed | ||
| Combined Letrozole-metformin-pioglitazone Versus Combined Clomiphene Citrate-metformin-pioglitazone in Clomiphene Citrate-resistant Women With Polycystic Ovary Syndrome[NCT01909141] | Early Phase 1 | 100 participants (Actual) | Interventional | 2013-08-31 | Completed | ||
| The Angiotensin-Melatonin Axis in Poor and Hyper Responders for IVF Treatment[NCT05298657] | 200 participants (Anticipated) | Observational [Patient Registry] | 2022-09-01 | Not yet recruiting | |||
| A Multicenter Randomized Trial of Personalized Acupuncture, Fixed Acupuncture, Letrozole and Placebo on Live Birth for Infertility in Women With Polycystic Ovary Syndrome[NCT03625531] | Phase 3 | 1,100 participants (Anticipated) | Interventional | 2018-08-13 | Recruiting | ||
| Follicular Synchronization in Polycystic Ovarian Syndrome Patients Undergoing Intracytoplasmatic Sperm Injection With Letrozole /Antagonist Protocol: A Randomized Controlled Trial[NCT04069117] | Phase 4 | 200 participants (Actual) | Interventional | 2019-08-01 | Completed | ||
| Phase II Randomized Study of Neoadjuvant Metformin Plus Letrozole vs Placebo Plus Letrozole for ER-positive Postmenopausal Breast Cancer[NCT01589367] | Phase 2 | 208 participants (Actual) | Interventional | 2012-05-31 | Completed | ||
| Clomiphene Citrate Plus HPuFSH Versus Letrozole Plus HPuFSH in Clomid Resistant Infertile PCOS Women[NCT01793038] | 160 participants (Anticipated) | Interventional | 2013-03-31 | Recruiting | |||
| Clomiphene Citrate Co-treatment With Low Dose HP Urinary FSH vs. HP Urinary FSH Step-up Protocol for Clomiphene-citrate Resistant PCOS Anovulatory Infertility: Randomized Controlled Trial[NCT01212263] | 174 participants (Actual) | Interventional | 2010-01-31 | Completed | |||
| [NCT01514942] | Phase 4 | 0 participants | Interventional | Completed | |||
| Multi-Centre Randomised Controlled Trial of the Effectiveness of Metformin and Clomiphene Citrate for Treating Anovulatory Infertility in Women With Polycystic Ovary Syndrome[NCT00795808] | Phase 4 | 171 participants (Actual) | Interventional | 2003-08-31 | Completed | ||
| A Multicenter, Prospective, Randomized Study to Assess the Effect of Metformin Supplementation on IVF Outcome and Intrafollicular Environment in Patients With Polycystic Ovarian Syndrome Undergoing In Vitro Fertilization/Embryo Transfer[NCT03086005] | Phase 3 | 24 participants (Actual) | Interventional | 2011-10-12 | Completed | ||
| Metformin Treatment Before IVF / ICSI in Non-obese Women With Polycystic Ovarian Syndrome[NCT00159575] | Phase 4 | 150 participants (Actual) | Interventional | 2005-03-31 | Terminated (stopped due to Slow patient recruitment and expiry of study medication(aug2009)) | ||
| Effects of Metformin on the Ovarian Response to Gonadotropins for in Vitro Fertilization Treatment in Patients With Polycystic Ovary Syndrome and Predictors of Poor Ovarian Response[NCT01208740] | Phase 4 | 88 participants (Actual) | Interventional | 2009-01-31 | Terminated (stopped due to Concerns about safety at the first interim analysis) | ||
| Effects of Inositol Alone or Associated With Alpha-lipoic Acid in Polycystic Ovary Syndrome Treatment[NCT04881851] | 90 participants (Anticipated) | Interventional | 2015-05-07 | Recruiting | |||
| PCOS and IVF: A Comparison Between Standard Long Protocol Versus an Antagonist Protocol Starting on Day 1[NCT00883766] | 172 participants (Anticipated) | Interventional | 2009-04-30 | Terminated | |||
| Efficacy and Safety of Furocyst in Patients With Poly Cystic Ovary Syndrome[NCT02789488] | Phase 4 | 50 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| Effects of Metformin on Fertility and Pregnancy in Women With Polycystic Ovary Syndrome: a Randomized, Prospective, Placebo-controlled Multicenter Study[NCT00994812] | Phase 3 | 326 participants (Actual) | Interventional | 2002-08-31 | Completed | ||
| What is the Following Step to Improve Fertility in Infertile PCOS Patients Ovulating Under Clomiphene Citrate or Metformin? A Randomized Controlled Clinical Study.[NCT00502229] | Phase 4 | 0 participants (Actual) | Interventional | 2010-01-31 | Withdrawn | ||
| Metformin Addition to Gonadotropins Ovarian Stimulation in High Responder Patients With PCOS Undergoing In-vitro Fertilization[NCT01233206] | Phase 4 | 120 participants (Actual) | Interventional | 2009-05-31 | Completed | ||
| Letrozole Versus Combined Metformin and Clomiphene Citrate for Ovulation Induction in Clomiphene-Resistant Women With Polycystic Ovary Syndrome[NCT00911313] | 250 participants (Actual) | Interventional | 2006-06-30 | Completed | |||
| Combined Metformin and Clomiphene Citrate Versus Laparoscopic Ovarian Diathermy for Ovulation Induction in Clomiphene-resistant Women With Polycystic Ovary Syndrome[NCT00969631] | 282 participants (Actual) | Interventional | 2005-09-30 | Completed | |||
| N-acetyl Cysteine Plus Clomiphene Citrate Versus Metformin and Clomiphene Citrate in Treatment of Clomiphene-resistant Polycystic Ovary Syndrome[NCT01008046] | 192 participants (Actual) | Interventional | 2007-04-30 | Completed | |||
| Clomiphene Citrate Versus Metformin as First-Line Approach for the Treatment of Anovulation in Infertile Patients With Polycystic Ovary Syndrome[NCT00471523] | Phase 4 | 80 participants (Actual) | Interventional | 2006-05-31 | Completed | ||
| Descriptive, Transversal Study of Evaluation of Cardiovascular Risks Factors and Prevalence of Metabolic Syndrome in the Different Phenotypes of Women With Polycystic Ovary Syndrome[NCT00784615] | 80 participants (Anticipated) | Observational | 2007-12-31 | Recruiting | |||
| Clinical Metabolic and Endocrine Parameters in Response to Metformin and Lifestyle Intervention in Women With Polycystic Ovary Syndrome: A Phase 4 Randomized, Double- Blind and Placebo Control Trial[NCT00679679] | Phase 4 | 30 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| Comparison of Three Different Strategies for Treating Infertility in Anovulatory Women With Polycystic Ovary Syndrome: a Multicentre Randomized Controlled Clinical Trial[NCT00461643] | Phase 4 | 552 participants (Anticipated) | Interventional | 2007-01-31 | Recruiting | ||
| Efficacy of Long- Versus Short-term Metformin Protocol in Infertile Anovulatory PCOS Patients[NCT00501904] | Phase 4 | 20 participants (Anticipated) | Interventional | 2012-04-30 | Recruiting | ||
| How Long Should First-line Treatment be Continued in Infertile PCOS Patients Who Ovulate Under Clomiphene Citrate? A Randomized Controlled Clinical Study.[NCT00501839] | Phase 4 | 0 participants (Actual) | Interventional | 2008-08-31 | Withdrawn | ||
| The Experience of Living With Polycystic Ovary Syndrome in the Military[NCT03876665] | 24 participants (Actual) | Observational | 2019-08-15 | Completed | |||
| Different Variables Predicting Ovulatory Response Among Clomiphene Citrate Resistance and Clomiphene Citrate Sensitive Patients With Polycystic Ovarian Syndrome.[NCT04887402] | 100 participants (Anticipated) | Observational [Patient Registry] | 2021-01-01 | Recruiting | |||
| Effects of Triple Drug Cocktail Therapy on Metabolic, Endocrine Alterations and Perceived Stress Response in Patients With PCOS: A Double Blind Randomized Clinical Trial[NCT04113889] | Phase 2 | 147 participants (Actual) | Interventional | 2019-10-15 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Primary outcome for years 2002-2008 defined according to American Diabetes Association criteria (fasting plasma glucose level >= 126 mg/dL [7.0 mmol/L] or 2-hour plasma glucose >= 200 mg/dL [11.1 mmol/L], after a 75 gram oral glucose tolerance test (OGTT), and confirmed with a repeat test). (NCT00038727)
Timeframe: Outcomes were assessed from 1996-2008 (approximately 12 years including 6 years of DPP).
| Intervention | diabetes incidence (cases per 100 person (Number) |
|---|---|
| 1 Original Lifestyle | 5.3 |
| 2 Original Metformin | 6.4 |
| 3 Original Placebo | 7.8 |
All cause-mortality through clinic reports and National Death Index search (NCT00038727)
Timeframe: Outcomes were assessed throughout follow-up from 1996 to 2022. National Death Index search conducted in 2019 using early release data as of Dec 2018.
| Intervention | Participants (Count of Participants) |
|---|---|
| 1 Original Lifestyle | 158 |
| 2 Original Metformin | 152 |
| 3 Original Placebo | 143 |
Aggregate microvascular disease is defined as the average prevalence of 3 components: (1) retinopathy measured by photography (ETDRS of 20 or greater); (2) neuropathy detected by Semmes Weinstein 10 gram monofilament, and (3) nephropathy based on estimated glomerular filtration rate (eGFR by chronic kidney disease (CKD-Epi) equation ) (<45 ml/min, confirmed) and albumin-to-creatinine ratio in spot urine (> 30mg/gm, confirmed). (NCT00038727)
Timeframe: Outcomes were assessed from 2012-2013 (approximately 2 years).
| Intervention | average percentage of participants (Number) |
|---|---|
| 1 Original Lifestyle | 11.3 |
| 2 Original Metformin | 13 |
| 3 Original Placebo | 12.4 |
Measured using coronary artery calcification (CAC). (NCT00038727)
Timeframe: Outcomes were assessed from 2012-2013 (approximately 2 years).
| Intervention | CAC geometric mean in AU (Geometric Mean) | |
|---|---|---|
| Men | Women | |
| 1 Original Lifestyle | 70.1 | 6.0 |
| 2 Original Metformin | 40.2 | 6.1 |
| 3 Original Placebo | 63.7 | 5.3 |
Systolic blood pressure was measured in mmHg. (NCT03151005)
Timeframe: 12 weeks
| Intervention | mmHg (Mean) |
|---|---|
| Metformin-GLP-1 Receptor Agonist | 122.83 |
| Metformin-Oral Contraceptive(OC) | 122.40 |
Alanine transaminase was measured in IU/L. (NCT03151005)
Timeframe: 12 weeks
| Intervention | IU/L (Mean) |
|---|---|
| Metformin-GLP-1 Receptor Agonist | 39.09 |
| Metformin-Oral Contraceptive(OC) | 36.73 |
Changes in testosterone levels were measured (NCT03151005)
Timeframe: 12 weeks
| Intervention | nmol/L (Mean) |
|---|---|
| Metformin-GLP-1 Receptor Agonist | 1.82 |
| Metformin-Oral Contraceptive(OC) | 2.14 |
Concentration of LH was measured in mIU/ml. (NCT03151005)
Timeframe: 12 weeks
| Intervention | mIU/ml (Mean) |
|---|---|
| Metformin-GLP-1 Receptor Agonist | 5.52 |
| Metformin-Oral Contraceptive(OC) | 5.33 |
Weight and height will be combined to report BMI in kg/m^2. (NCT03151005)
Timeframe: 12 weeks
| Intervention | kg/m^2 (Mean) |
|---|---|
| Metformin-GLP-1 Receptor Agonist | 26.26 |
| Metformin-Oral Contraceptive(OC) | 27.12 |
(NCT01909141)
Timeframe: 3 months
| Intervention | mm (Mean) |
|---|---|
| Arm 1:Letrozole-pioglitazone -Metformin Group | 10.56 |
| Arm 2: Clomiphene Citrate-pioglitazone-metformin | 9.68 |
(NCT01909141)
Timeframe: 3 months
| Intervention | follicles (Mean) |
|---|---|
| Arm 1:Letrozole-pioglitazone -Metformin Group | 1.44 |
| Arm 2: Clomiphene Citrate-pioglitazone-metformin | 1.5 |
(NCT01909141)
Timeframe: 3 months
| Intervention | percentage of all cycles (Number) |
|---|---|
| Arm 1:Letrozole-pioglitazone -Metformin Group | 93 |
| Arm 2: Clomiphene Citrate-pioglitazone-metformin | 108 |
(NCT01909141)
Timeframe: 3 months
| Intervention | participants (Number) |
|---|---|
| Arm 1:Letrozole-pioglitazone -Metformin Group | 28 |
| Arm 2: Clomiphene Citrate-pioglitazone-metformin | 24 |
serum creatinine was measured at the end of the study period (after 3 months) in both groups. (NCT01909141)
Timeframe: 3 months
| Intervention | mg/dL (Mean) |
|---|---|
| Arm 1:Letrozole-pioglitazone -Metformin Group | 0.62 |
| Arm 2: Clomiphene Citrate-pioglitazone-metformin | 0.57 |
90 reviews available for metformin and Infertility, Female
| Article | Year |
|---|---|
Therapeutic efficacy of clomiphene citrate combined with metformin in patients with polycystic ovary syndrome.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Metformin; Ovulation Indu | 2022 |
Does metformin improve reproduction outcomes for non-obese, infertile women with polycystic ovary syndrome? Meta-analysis and systematic review.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Live Birth; Metformin; Ov | 2022 |
The use of metformin in women with polycystic ovary syndrome: an updated review.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Hypoglycemic Agents; Infertility, Female; Insu | 2022 |
The effects of first-line pharmacological treatments for reproductive outcomes in infertile women with PCOS: a systematic review and network meta-analysis.
Topics: Abortion, Spontaneous; Clomiphene; Female; Humans; Infertility, Female; Live Birth; Metformin; Netwo | 2023 |
First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis.
Topics: Birth Rate; Clomiphene; Female; Fertility Agents, Female; Gonadotropins; Humans; Infertility, Female | 2019 |
Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Birth Rate; Body Mass Index; Clomiphene; Female; Fertility Agents, Female; Hu | 2019 |
Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Birth Rate; Body Mass Index; Clomiphene; Female; Fertility Agents, Female; Hu | 2019 |
Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Birth Rate; Body Mass Index; Clomiphene; Female; Fertility Agents, Female; Hu | 2019 |
Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Birth Rate; Body Mass Index; Clomiphene; Female; Fertility Agents, Female; Hu | 2019 |
Effects of lifestyle modification in polycystic ovary syndrome compared to metformin only or metformin addition: A systematic review and meta-analysis.
Topics: Biomarkers; Body Weights and Measures; Female; Humans; Hypoglycemic Agents; Infertility, Female; Lif | 2020 |
Obesity, Polycystic Ovary Syndrome, and Infertility: A New Avenue for GLP-1 Receptor Agonists.
Topics: Drug Therapy, Combination; Female; Glucagon-Like Peptide-1 Receptor; Humans; Incretins; Infertility, | 2020 |
Obesity, Polycystic Ovary Syndrome, and Infertility: A New Avenue for GLP-1 Receptor Agonists.
Topics: Drug Therapy, Combination; Female; Glucagon-Like Peptide-1 Receptor; Humans; Incretins; Infertility, | 2020 |
Obesity, Polycystic Ovary Syndrome, and Infertility: A New Avenue for GLP-1 Receptor Agonists.
Topics: Drug Therapy, Combination; Female; Glucagon-Like Peptide-1 Receptor; Humans; Incretins; Infertility, | 2020 |
Obesity, Polycystic Ovary Syndrome, and Infertility: A New Avenue for GLP-1 Receptor Agonists.
Topics: Drug Therapy, Combination; Female; Glucagon-Like Peptide-1 Receptor; Humans; Incretins; Infertility, | 2020 |
Endometrial function in women with polycystic ovary syndrome: a comprehensive review.
Topics: Endometrium; Female; Humans; Infertility, Female; Insulin Resistance; Metformin; Polycystic Ovary Sy | 2021 |
Metformin and health outcomes: An umbrella review of systematic reviews with meta-analyses.
Topics: Body Mass Index; Cardiovascular Diseases; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Fema | 2021 |
Pharmacological and non-pharmacological strategies for obese women with subfertility.
Topics: Abortion, Spontaneous; Appetite Depressants; Bias; Carnitine; Clomiphene; Dexfenfluramine; Drug Ther | 2021 |
Therapeutic approach for metabolic disorders and infertility in women with PCOS.
Topics: Androgen Antagonists; Anovulation; Clomiphene; Contraceptives, Oral, Hormonal; Female; Gonadotropins | 2018 |
Role of metformin for ovulation induction in infertile patients with polycystic ovary syndrome (PCOS): a guideline.
Topics: Comorbidity; Evidence-Based Medicine; Female; Humans; Infertility, Female; Metformin; Ovulation Indu | 2017 |
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
Topics: Abortion, Spontaneous; Anovulation; Clomiphene; Female; Humans; Hypoglycemic Agents; Infertility, Fe | 2017 |
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
Topics: Abortion, Spontaneous; Anovulation; Clomiphene; Female; Humans; Hypoglycemic Agents; Infertility, Fe | 2017 |
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
Topics: Abortion, Spontaneous; Anovulation; Clomiphene; Female; Humans; Hypoglycemic Agents; Infertility, Fe | 2017 |
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
Topics: Abortion, Spontaneous; Anovulation; Clomiphene; Female; Humans; Hypoglycemic Agents; Infertility, Fe | 2017 |
[Polycystic ovary syndrome - current state of knowledge].
Topics: Adult; Clomiphene; Diabetes Mellitus, Type 2; Female; Fertility Agents, Female; Humans; Infertility, | 2018 |
Inositol for subfertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Administration, Oral; Birth Rate; Clomiphene; Combined Modality Therapy; Fema | 2018 |
Effect of metformin on ovulation and reproductive outcomes in women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials.
Topics: Clomiphene; Confidence Intervals; Female; Fertility Agents, Female; Humans; Infertility, Female; Liv | 2013 |
Diverse roles of metformin during peri-implantation development: revisiting novel molecular mechanisms underlying clinical implications.
Topics: Abortion, Spontaneous; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Embryo I | 2013 |
Metformin and gonadotropins for ovulation induction in patients with polycystic ovary syndrome: a systematic review with meta-analysis of randomized controlled trials.
Topics: Birth Rate; Female; Fertility Agents, Female; Gonadotropins; Humans; Infertility, Female; Metformin; | 2014 |
Polycystic ovary syndrome: current status and future perspective.
Topics: Androgens; Disease Management; Female; Humans; Hyperandrogenism; Infertility, Female; Insulin Resist | 2014 |
Medical and surgical interventions to improve outcomes in obese women planning for pregnancy.
Topics: Bariatric Surgery; Exercise; Feeding Behavior; Female; Humans; Hypoglycemic Agents; Infertility, Fem | 2015 |
Novel strategies in the management of polycystic ovary syndrome.
Topics: Adult; Clomiphene; Contraceptives, Oral, Combined; Female; Fertility Agents, Female; Fertilization i | 2015 |
Metformin treatment before and during in vitro fertilization or intracytoplasmic sperm injection in women with polycystic ovary syndrome: summary of a Cochrane review.
Topics: Chi-Square Distribution; Female; Fertility; Fertilization in Vitro; Humans; Hypoglycemic Agents; Inf | 2015 |
[Evidence-based therapy of polycystic ovarian syndrome].
Topics: Amenorrhea; Androgen Antagonists; Anovulation; Anti-Obesity Agents; Chorionic Gonadotropin; Contrace | 2015 |
Treatment strategies for the infertile polycystic ovary syndrome patient.
Topics: Anovulation; Antineoplastic Agents; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, | 2015 |
[Prevention and treatment of the complications of polycystic ovarian syndrome--the significance of evidence-based, interdisciplinary management].
Topics: Biomarkers; Counseling; Dermatology; Diabetes Mellitus, Type 2; Disease Management; Endocrinology; E | 2015 |
Twenty years of ovulation induction with metformin for PCOS; what is the best available evidence?
Topics: Evidence-Based Practice; Female; Humans; Infertility, Female; Metformin; Ovulation Induction; Polycy | 2016 |
Mono-ovulation in women with polycystic ovary syndrome: a clinical review on ovulation induction.
Topics: Adult; Anovulation; Body Weight; Clomiphene; Female; Fertility Agents, Female; Gonadotropins; Humans | 2016 |
The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance.
Topics: Anovulation; Aromatase Inhibitors; Clomiphene; Consensus; Female; Fertility Agents, Female; Fertiliz | 2016 |
Ovulation induction in polycystic ovary syndrome: Current options.
Topics: Anovulation; Anti-Obesity Agents; Aromatase Inhibitors; Bariatric Surgery; Clomiphene; Diet Therapy; | 2016 |
Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination for subfertility associated with polycystic ovary syndrome.
Topics: Coitus; Combined Modality Therapy; Drug Therapy, Combination; Female; Fertility Agents, Female; Fert | 2017 |
Treatment strategies for women with WHO group II anovulation: systematic review and network meta-analysis
Topics: Anovulation; Clomiphene; Drug Therapy, Combination; Female; Humans; Infertility, Female; Letrozole; | 2017 |
[Metformin therapy in polycystic ovary syndrome].
Topics: Clomiphene; Drug Administration Schedule; Drug Therapy, Combination; Female; Fertility Agents, Femal | 2008 |
Drugs in infertility and fetal safety.
Topics: Clomiphene; Estrogens; Female; Fertility Agents, Female; Fetus; Gonadotropins; Humans; Infertility, | 2008 |
Clomiphene citrate, metformin or both as first-step approach in treating anovulatory infertility in patients with polycystic ovary syndrome (PCOS): a systematic review of head-to-head randomized controlled studies and meta-analysis.
Topics: Anovulation; Clomiphene; Drug Therapy, Combination; Female; Humans; Infertility, Female; Metformin; | 2009 |
PCOS and infertility.
Topics: Clomiphene; Female; Fertility Agents, Female; Gonadotropin-Releasing Hormone; Humans; Hypoglycemic A | 2008 |
Use of metformin in polycystic ovary syndrome.
Topics: Adolescent; Adult; Clomiphene; Dose-Response Relationship, Drug; Drug Administration Schedule; Femal | 2008 |
The use of metformin in the management of polycystic ovary syndrome and associated anovulatory infertility: the current evidence.
Topics: Anovulation; Female; Humans; Hypoglycemic Agents; Infertility, Female; Metformin; Patient Selection; | 2009 |
Management strategies for ovulation induction in women with polycystic ovary syndrome and known clomifene citrate resistance.
Topics: Acetylcysteine; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Bromocriptine; Clomiphene; De | 2009 |
Management strategies for ovulation induction in women with polycystic ovary syndrome and known clomifene citrate resistance.
Topics: Acetylcysteine; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Bromocriptine; Clomiphene; De | 2009 |
Management strategies for ovulation induction in women with polycystic ovary syndrome and known clomifene citrate resistance.
Topics: Acetylcysteine; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Bromocriptine; Clomiphene; De | 2009 |
Management strategies for ovulation induction in women with polycystic ovary syndrome and known clomifene citrate resistance.
Topics: Acetylcysteine; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Bromocriptine; Clomiphene; De | 2009 |
Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome.
Topics: Female; Humans; Hypoglycemic Agents; Infertility, Female; Insulin Resistance; Metformin; Polycystic | 2010 |
Should physicians prescribe metformin to women with polycystic ovary syndrome PCOS?
Topics: Adult; Body Mass Index; Clomiphene; Diabetes Mellitus; Diabetes, Gestational; Female; Fertility Agen | 2010 |
Best methods for identification and treatment of PCOS.
Topics: Androgens; Aromatase Inhibitors; Clomiphene; Contraceptives, Oral, Hormonal; Diagnosis, Differential | 2010 |
Fertility treatment in women with polycystic ovary syndrome: a decision analysis of different oral ovulation induction agents.
Topics: Administration, Oral; Adult; Algorithms; Clomiphene; Decision Support Techniques; Drug Combinations; | 2010 |
Metformin in polycystic ovary syndrome.
Topics: Cardiovascular Diseases; Female; Humans; Hypoglycemic Agents; Infertility, Female; Metabolic Disease | 2010 |
Metformin is a reasonable first-line treatment option for non-obese women with infertility related to anovulatory polycystic ovary syndrome--a meta-analysis of randomised trials.
Topics: Anovulation; Body Mass Index; Clomiphene; Drug Therapy, Combination; Female; Humans; Infertility, Fe | 2011 |
Ovarian drilling for surgical treatment of polycystic ovarian syndrome: a comprehensive review.
Topics: Clomiphene; Female; Humans; Infertility, Female; Laparoscopy; Metformin; Ovary; Ovulation Induction; | 2011 |
Metformin and/or clomiphene do not adversely affect liver or renal function in women with polycystic ovary syndrome.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Clomiphene; Double-Blind Method | 2011 |
Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview.
Topics: Abortion, Spontaneous; Diabetes, Gestational; Female; Humans; Hyperandrogenism; Hyperinsulinism; Hyp | 2012 |
Is metformin indicated as primary ovulation induction agent in women with PCOS? A systematic review and meta-analysis.
Topics: Clomiphene; Drug Resistance; Drug Therapy, Combination; Female; Humans; Infertility, Female; Live Bi | 2012 |
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
Topics: Anovulation; Clomiphene; Female; Humans; Hypoglycemic Agents; Infertility, Female; Inositol; Insulin | 2012 |
The treatment of infertility in polycystic ovary syndrome: a brief update.
Topics: Adult; Anovulation; Clomiphene; Evidence-Based Medicine; Female; Fertility Agents, Female; Gonadotro | 2012 |
The effectiveness of metformin ovulation induction treatment in patients with PCOS: a systematic review and meta-analysis.
Topics: Abortion, Spontaneous; Clomiphene; Drug Therapy, Combination; Estrogen Antagonists; Evidence-Based M | 2012 |
[Treatment of infertility].
Topics: Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Fertilization in Vi | 2012 |
Status of clomiphene citrate and metformin for infertility in PCOS.
Topics: Clomiphene; Female; Humans; Infertility, Female; Metformin; Ovulation Induction; Polycystic Ovary Sy | 2012 |
Long versus short course treatment with metformin and clomiphene citrate for ovulation induction in women with PCOS.
Topics: Clomiphene; Drug Administration Schedule; Drug Therapy, Combination; Female; Fertility Agents, Femal | 2012 |
Ovulation induction in the management of anovulatory polycystic ovary syndrome.
Topics: Anovulation; Aromatase Inhibitors; Clomiphene; Female; Gonadotropins; Humans; Hypoglycemic Agents; I | 2013 |
Reproductive impact of polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Clomiphene; Female; Fertilization in Vitro; Humans; Infant, Newborn; Infertil | 2012 |
[Therapeutic effect of metformin for clomiphene-resistant infertility patients with polycystic ovary syndrome: a systematic analysis].
Topics: Clomiphene; Drug Resistance; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; In | 2012 |
Polycystic ovarian syndrome management options.
Topics: Clomiphene; Contraceptives, Oral, Hormonal; Estrogen Antagonists; Exercise; Female; Humans; Infertil | 2012 |
Evaluation and treatment of anovulatory and unexplained infertility.
Topics: Anovulation; Clomiphene; Diet; Evidence-Based Medicine; Exercise; Female; Fertility Agents, Female; | 2012 |
Effects of metformin in women with polycystic ovary syndrome treated with gonadotrophins for in vitro fertilisation and intracytoplasmic sperm injection cycles: a systematic review and meta-analysis of randomised controlled trials.
Topics: Abortion, Spontaneous; Dinoprostone; Embryo Implantation; Female; Fertility Agents, Female; Fertiliz | 2013 |
[When and how should polycystic ovary syndrome be treated?].
Topics: Androgen Antagonists; Contraceptives, Oral, Hormonal; Female; Humans; Hypoglycemic Agents; Infertili | 2001 |
Should patients with polycystic ovary syndrome be treated with metformin? Benefits of insulin sensitizing drugs in polycystic ovary syndrome--beyond ovulation induction.
Topics: Androgens; Cardiovascular Diseases; Female; Fertilization in Vitro; Gonadotropins; Humans; Hypoglyce | 2002 |
A systematic review of the reproductive system effects of metformin in patients with polycystic ovary syndrome.
Topics: Clomiphene; Drug Therapy, Combination; Female; Fertilization in Vitro; Follicle Stimulating Hormone; | 2003 |
[Insulin resistance and polycystic ovary syndrome].
Topics: Female; Humans; Hyperandrogenism; Hypoglycemic Agents; Infertility, Female; Insulin Resistance; Metf | 2003 |
[Should infertile women with polycystic ovarian syndrome be treated with metformine?].
Topics: Clomiphene; Drug Synergism; Estrogen Antagonists; Female; Fertility Agents, Female; Humans; Hyperand | 2003 |
[Insulin resistance in polycystic ovary syndrome].
Topics: Adolescent; Adult; Body Mass Index; Cardiovascular Diseases; Chromans; Controlled Clinical Trials as | 2003 |
Metformin for the treatment of the polycystic ovary syndrome.
Topics: Adolescent; Adult; Amenorrhea; Clinical Trials as Topic; Clomiphene; Diabetes Mellitus, Type 2; Diab | 2004 |
Review of nonsurgical and surgical treatment and the role of insulin-sensitizing agents in the management of infertile women with polycystic ovary syndrome.
Topics: Adult; Anovulation; Clomiphene; Drug Resistance; Electrocoagulation; Female; Fertility Agents, Femal | 2004 |
Insulin resistance and metformin in polycystic ovary syndrome.
Topics: Cardiovascular Diseases; Diabetes Mellitus; Female; Humans; Hyperinsulinism; Hypoglycemic Agents; In | 2004 |
Insulin-sensitizing agents as primary therapy for patients with polycystic ovarian syndrome.
Topics: Clomiphene; Cohort Studies; Female; Fertility Agents, Female; Humans; Hypoglycemic Agents; Infertili | 2004 |
Is ovulation induction still a therapeutic problem in patients with polycystic ovary syndrome?
Topics: Aromatase Inhibitors; Clomiphene; Diet; Female; Fertility Agents, Female; Humans; Hypoglycemic Agent | 2004 |
[Metformin for the treatment of polycystic ovary syndrome].
Topics: Female; Humans; Hyperinsulinism; Hypoglycemic Agents; Infertility, Female; Insulin Resistance; Metfo | 2005 |
Patient-tailored conventional ovulation induction algorithms in anovulatory infertility.
Topics: Algorithms; Anovulation; Clomiphene; Electrocoagulation; Female; Fertilization in Vitro; Follicle St | 2005 |
Ovulation induction in infertile patients with polycystic ovary syndrome.
Topics: Aromatase Inhibitors; Clomiphene; Decision Trees; Diet; Drug Therapy, Combination; Female; Gonadotro | 2006 |
Ovulatory disorders and infertility.
Topics: Anovulation; Clomiphene; Female; Fertility Agents, Female; Glucocorticoids; Gonadotropin-Releasing H | 2006 |
Female infertility.
Topics: Clomiphene; Endometriosis; Fallopian Tubes; Female; Fertility Agents, Female; Fertilization in Vitro | 2006 |
Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review.
Topics: Clomiphene; Drug Combinations; Drug Resistance; Female; Fertility Agents, Female; Humans; Infertilit | 2006 |
Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review.
Topics: Clomiphene; Drug Combinations; Drug Resistance; Female; Fertility Agents, Female; Humans; Infertilit | 2006 |
Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review.
Topics: Clomiphene; Drug Combinations; Drug Resistance; Female; Fertility Agents, Female; Humans; Infertilit | 2006 |
Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review.
Topics: Clomiphene; Drug Combinations; Drug Resistance; Female; Fertility Agents, Female; Humans; Infertilit | 2006 |
Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review.
Topics: Clomiphene; Drug Combinations; Drug Resistance; Female; Fertility Agents, Female; Humans; Infertilit | 2006 |
Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review.
Topics: Clomiphene; Drug Combinations; Drug Resistance; Female; Fertility Agents, Female; Humans; Infertilit | 2006 |
Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review.
Topics: Clomiphene; Drug Combinations; Drug Resistance; Female; Fertility Agents, Female; Humans; Infertilit | 2006 |
Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review.
Topics: Clomiphene; Drug Combinations; Drug Resistance; Female; Fertility Agents, Female; Humans; Infertilit | 2006 |
Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review.
Topics: Clomiphene; Drug Combinations; Drug Resistance; Female; Fertility Agents, Female; Humans; Infertilit | 2006 |
Contemporary medical therapy for polycystic ovary syndrome.
Topics: Acne Vulgaris; Adult; Clomiphene; Estrogen Antagonists; Female; Hirsutism; Humans; Hypoglycemic Agen | 2006 |
Is metformin a primary ovulatory agent in patients with polycystic ovary syndrome?
Topics: Anovulation; Clinical Trials as Topic; Female; Fertility Agents, Female; Humans; Infertility, Female | 2006 |
Infertility in polycystic ovary syndrome: focus on low-dose gonadotropin treatment.
Topics: Adult; Anovulation; Clomiphene; Female; Gonadotropins; Humans; Infertility, Female; Metformin; Ovula | 2006 |
Lifestyle choices, diet, and insulin sensitizers in polycystic ovary syndrome.
Topics: Age Factors; Alcohol Drinking; Body Weight; Caffeine; Female; Humans; Hypoglycemic Agents; Infertili | 2006 |
Lifestyle choices, diet, and insulin sensitizers in polycystic ovary syndrome.
Topics: Age Factors; Alcohol Drinking; Body Weight; Caffeine; Female; Humans; Hypoglycemic Agents; Infertili | 2006 |
Lifestyle choices, diet, and insulin sensitizers in polycystic ovary syndrome.
Topics: Age Factors; Alcohol Drinking; Body Weight; Caffeine; Female; Humans; Hypoglycemic Agents; Infertili | 2006 |
Lifestyle choices, diet, and insulin sensitizers in polycystic ovary syndrome.
Topics: Age Factors; Alcohol Drinking; Body Weight; Caffeine; Female; Humans; Hypoglycemic Agents; Infertili | 2006 |
Triplet pregnancy after metformin in a woman with polycystic ovary syndrome.
Topics: Adult; Female; Humans; Hypoglycemic Agents; Infertility, Female; Metformin; Polycystic Ovary Syndrom | 2008 |
Polycystic ovary syndrome.
Topics: Acne Vulgaris; Androgen Antagonists; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fem | 2008 |
Managing anovulatory infertility and polycystic ovary syndrome.
Topics: Anovulation; Female; Humans; Hypoglycemic Agents; Infertility, Female; Metformin; Obesity; Ovulation | 2007 |
Polycystic ovarian syndrome--prognosis and treatment outcomes.
Topics: Anovulation; Cardiovascular Diseases; Combined Modality Therapy; Contraceptives, Oral; Diabetes Mell | 2007 |
Long versus short course treatment with Metformin and Clomiphene Citrate for ovulation induction in women with PCOS.
Topics: Clomiphene; Drug Administration Schedule; Drug Therapy, Combination; Female; Fertility Agents, Femal | 2008 |
Outlook: metformin use in infertile patients with polycystic ovary syndrome: an evidence-based overview.
Topics: Female; Gonadotropins; Humans; Hypoglycemic Agents; Infertility, Female; Insulin Resistance; Meta-An | 2008 |
Induction of ovulation in infertile women with hyperandrogenism and insulin resistance.
Topics: Acanthosis Nigricans; Female; Humans; Hyperandrogenism; Hypoglycemic Agents; Infertility, Female; In | 2000 |
Strategies for the use of insulin-sensitizing drugs to treat infertility in women with polycystic ovary syndrome.
Topics: Algorithms; Clomiphene; Female; Fertility Agents, Female; Humans; Hypoglycemic Agents; Infertility, | 2002 |
64 trials available for metformin and Infertility, Female
| Article | Year |
|---|---|
Effect of metformin and exenatide on pregnancy rate and pregnancy outcomes in overweight or obese infertility PCOS women: long-term follow-up of an RCT.
Topics: Exenatide; Female; Follow-Up Studies; Humans; Hypoglycemic Agents; Infertility, Female; Metformin; O | 2022 |
A Prospective Cohort Study of Metformin as an Adjuvant Therapy for Infertile Women With Endometrial Complex Hyperplasia/Complex Atypical Hyperplasia and Their Subsequent Assisted Reproductive Technology Outcomes.
Topics: Endometrial Hyperplasia; Female; Humans; Hyperplasia; Infertility, Female; Metformin; Polycystic Ova | 2022 |
Infertility, Gravidity, and Risk Of Diabetes among High-Risk Women in the Diabetes Prevention Program Outcomes Study.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Gravidity; Humans; Incidence; Infertility, Female; L | 2020 |
Impact of myoinositol with metformin and myoinositol alone in infertile PCOS women undergoing ovulation induction cycles - randomized controlled trial.
Topics: Adult; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Infertility, Female; Inositol | 2021 |
Comparison of metformin and N-acetyl cysteine, as an adjuvant to clomiphene citrate, in clomiphene-resistant women with polycystic ovary syndrome.
Topics: Acetylcysteine; Adjuvants, Pharmaceutic; Adult; Clomiphene; Drug Administration Schedule; Drug Resis | 2017 |
Normalizing Ovulation Rate by Preferential Reduction of Hepato-Visceral Fat in Adolescent Girls With Polycystic Ovary Syndrome.
Topics: Adolescent; Body Mass Index; Contraceptives, Oral, Combined; Drug Combinations; Ethinyl Estradiol; F | 2017 |
Impact of Metformin on IVF Outcomes in Overweight and Obese Women With Polycystic Ovary Syndrome: A Randomized Double-Blind Controlled Trial.
Topics: Adult; Double-Blind Method; Female; Fertilization in Vitro; Humans; Hypoglycemic Agents; Infertility | 2019 |
Liraglutide increases IVF pregnancy rates in obese PCOS women with poor response to first-line reproductive treatments: a pilot randomized study.
Topics: Adult; Drug Therapy, Combination; Female; Fertilization in Vitro; Humans; Hypoglycemic Agents; Infer | 2018 |
Liraglutide increases IVF pregnancy rates in obese PCOS women with poor response to first-line reproductive treatments: a pilot randomized study.
Topics: Adult; Drug Therapy, Combination; Female; Fertilization in Vitro; Humans; Hypoglycemic Agents; Infer | 2018 |
Liraglutide increases IVF pregnancy rates in obese PCOS women with poor response to first-line reproductive treatments: a pilot randomized study.
Topics: Adult; Drug Therapy, Combination; Female; Fertilization in Vitro; Humans; Hypoglycemic Agents; Infer | 2018 |
Liraglutide increases IVF pregnancy rates in obese PCOS women with poor response to first-line reproductive treatments: a pilot randomized study.
Topics: Adult; Drug Therapy, Combination; Female; Fertilization in Vitro; Humans; Hypoglycemic Agents; Infer | 2018 |
[Effect of Qilin Pill Combined Metformin on Polycystic Ovaries Induced Infertility Patients].
Topics: Drugs, Chinese Herbal; Female; Humans; Hypoglycemic Agents; Infertility, Female; Luteinizing Hormone | 2016 |
l-Carnitine plus metformin in clomiphene-resistant obese PCOS women, reproductive and metabolic effects: a randomized clinical trial.
Topics: Adult; Blood Glucose; Carnitine; Clomiphene; Drug Resistance; Female; Fertility Agents, Female; Horm | 2019 |
The effectiveness of inositol and metformin on infertile polycystic ovary syndrome women with resistant to letrozole.
Topics: Adult; Female; Folic Acid; Humans; Infertility, Female; Inositol; Letrozole; Metformin; Ovulation In | 2019 |
The use of berberine for women with polycystic ovary syndrome undergoing IVF treatment.
Topics: Adult; Berberine; Female; Fertilization in Vitro; Humans; Hypoglycemic Agents; Infertility, Female; | 2014 |
Efficacy of combined metformin-clomiphene citrate in comparison with clomiphene citrate alone in infertile women with polycystic ovarian syndrome (PCOS).
Topics: Adult; Clomiphene; Drug Therapy, Combination; Female; Humans; Infertility, Female; Metformin; Polycy | 2013 |
Ovulation induction with clomiphene citrate and metformin in women with polycystic ovary syndrome.
Topics: Adult; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; Hypoglycemic | 2014 |
N-Acetylcysteine improves oocyte and embryo quality in polycystic ovary syndrome patients undergoing intracytoplasmic sperm injection: an alternative to metformin.
Topics: Academic Medical Centers; Acetylcysteine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antioxidan | 2016 |
[Using an ovarian drilling by hydrolaparoscopy or recombinant follicle stimulating hormone plus metformin to treat polycystic ovary syndrome: Why a randomized controlled trial fail?].
Topics: Adult; Clomiphene; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Humans; Hypoglyce | 2015 |
Pregnancy in polycystic ovary syndrome I: lessons from a pragmatic explanatory with repository clinical trial.
Topics: Adult; Anovulation; Clomiphene; Double-Blind Method; Female; Fertility Agents, Female; Humans; Hypog | 2015 |
The adjuvant effect of metformin and N-acetylcysteine to clomiphene citrate in induction of ovulation in patients with Polycystic Ovary Syndrome.
Topics: Acetylcysteine; Adult; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Huma | 2015 |
A randomized controlled trial of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone for clomifene-citrate-resistant polycystic ovary syndrome.
Topics: Adult; Clomiphene; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Egypt; Female; F | 2016 |
A short course of metformin does not reduce OHSS in a GnRH antagonist cycle for women with PCOS undergoing IVF: a randomised placebo-controlled trial.
Topics: Adult; Female; Gonadotropin-Releasing Hormone; Hormone Antagonists; Humans; Infertility, Female; Met | 2016 |
Intercourse compliance, ovulation, and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial.
Topics: Adult; Clomiphene; Coitus; Female; Fertility Agents, Female; Humans; Infertility, Female; Metformin; | 2010 |
The effects of calcium-vitamin D and metformin on polycystic ovary syndrome: a pilot study.
Topics: Administration, Oral; Adult; Calcium; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; | 2009 |
Comparison of metformin treatment and laparoscopic ovarian diathermy in patients with polycystic ovary syndrome.
Topics: Adult; Clomiphene; Diathermy; Female; Fertility Agents, Female; Hirsutism; Humans; Hypoglycemic Agen | 2009 |
RETRACTED: Letrozole versus combined metformin and clomiphene citrate for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial.
Topics: Adult; Algorithms; Clomiphene; Drug Combinations; Drug Resistance; Female; Fertility Agents, Female; | 2010 |
Laparoscopic ovarian diathermy vs clomiphene citrate plus metformin as second-line strategy for infertile anovulatory patients with polycystic ovary syndrome: a randomized controlled trial.
Topics: Abortion, Spontaneous; Anovulation; Body Mass Index; Clomiphene; Diathermy; Drug Therapy, Combinatio | 2010 |
Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women.
Topics: Adult; Anovulation; Dietary Supplements; Drug Therapy, Combination; Female; Fertility Agents, Female | 2010 |
PCOSMIC: a multi-centre randomized trial in women with PolyCystic Ovary Syndrome evaluating Metformin for Infertility with Clomiphene.
Topics: Anovulation; Clomiphene; Female; Humans; Hypoglycemic Agents; Infertility, Female; Metformin; Ovulat | 2010 |
Comparison of metformin and clomiphene citrate therapy for induction of ovulation in the polycystic ovary syndrome.
Topics: Adult; Anovulation; Clomiphene; Female; Fertility Agents, Female; Humans; Hypoglycemic Agents; Infer | 2010 |
[Indication of metformin in the management of hormonal dysfunction secondary to polycystic ovarian syndrome: prospective comparative study of 63 cases].
Topics: Adult; Clomiphene; Female; Fertility Agents, Female; Humans; Hypoglycemic Agents; Infertility, Femal | 2010 |
Randomized controlled trial of different doses of metformin for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Adult; Clomiphene; Dose-Response Relationship, Drug; Female; Fertility Agents, Female; Humans; Hyper | 2011 |
Use of metformin before and during assisted reproductive technology in non-obese young infertile women with polycystic ovary syndrome: a prospective, randomized, double-blind, multi-centre study.
Topics: Adult; Double-Blind Method; Female; Humans; Infertility, Female; Metformin; Polycystic Ovary Syndrom | 2011 |
Metformin and/or clomiphene do not adversely affect liver or renal function in women with polycystic ovary syndrome.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Clomiphene; Double-Blind Method | 2011 |
Does metformin affect the ovarian response to gonadotropins for in vitro fertilization treatment in patients with polycystic ovary syndrome and reduced ovarian reserve? A randomized controlled trial.
Topics: Adult; Chi-Square Distribution; Double-Blind Method; Early Termination of Clinical Trials; Female; F | 2011 |
Metformin improves pregnancy and live-birth rates in women with polycystic ovary syndrome (PCOS): a multicenter, double-blind, placebo-controlled randomized trial.
Topics: Abortion, Spontaneous; Adult; Birth Rate; Double-Blind Method; Female; Humans; Infertility, Female; | 2012 |
Health-related quality of life in women with newly diagnosed polycystic ovary syndrome randomized between clomifene citrate plus metformin or clomifene citrate plus placebo.
Topics: Adult; Anxiety; Clomiphene; Depression; Double-Blind Method; Female; Fertility Agents, Female; Human | 2012 |
Efficacy of combined metformin-letrozole in comparison with bilateral ovarian drilling in clomiphene-resistant infertile women with polycystic ovarian syndrome.
Topics: Adult; Aromatase Inhibitors; Blood Glucose; Clomiphene; Drug Therapy, Combination; Female; Fertility | 2013 |
The effect of metformin on ovarian stimulation and in vitro fertilization in insulin-resistant women with polycystic ovary syndrome: an open-label randomized cross-over trial.
Topics: Adult; Buserelin; Cross-Over Studies; Female; Fertilization in Vitro; Follicle Stimulating Hormone; | 2003 |
[Importance of sensitization of insulin receptors in the prevention of ovarian hyperstimulation syndrome].
Topics: Adult; Female; Humans; Infertility, Female; Insulin Resistance; Metformin; Ovarian Hyperstimulation | 2003 |
The effects of metformin on insulin resistance, clomiphene-induced ovulation and pregnancy rates in women with polycystic ovary syndrome.
Topics: Adult; Clomiphene; Endometrium; Female; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Inferti | 2004 |
Effects of metformin on clinical and biochemical parameters in polycystic ovary syndrome.
Topics: Adolescent; Adult; Female; Humans; Hypoglycemic Agents; Infertility, Female; Insulin; Insulin Resist | 2004 |
Metformin therapy in women with polycystic ovary syndrome.
Topics: Adolescent; Adult; Body Mass Index; Cholesterol; Female; Follicle Stimulating Hormone; Glucose Toler | 2004 |
Serum and follicular fluid levels of soluble Fas, soluble Fas ligand and apoptosis of luteinized granulosa cells in PCOS patients undergoing IVF.
Topics: Adult; Apoptosis; Biomarkers; Fas Ligand Protein; fas Receptor; Female; Fertilization in Vitro; Foll | 2005 |
A randomized controlled trial evaluating metformin pre-treatment and co-administration in non-obese insulin-resistant women with polycystic ovary syndrome treated with controlled ovarian stimulation plus timed intercourse or intrauterine insemination.
Topics: Adult; Area Under Curve; Chorionic Gonadotropin; Female; Follicle Stimulating Hormone; Gonadotropins | 2005 |
A randomized controlled trial evaluating metformin pre-treatment and co-administration in non-obese insulin-resistant women with polycystic ovary syndrome treated with controlled ovarian stimulation plus timed intercourse or intrauterine insemination.
Topics: Adult; Area Under Curve; Chorionic Gonadotropin; Female; Follicle Stimulating Hormone; Gonadotropins | 2005 |
A randomized controlled trial evaluating metformin pre-treatment and co-administration in non-obese insulin-resistant women with polycystic ovary syndrome treated with controlled ovarian stimulation plus timed intercourse or intrauterine insemination.
Topics: Adult; Area Under Curve; Chorionic Gonadotropin; Female; Follicle Stimulating Hormone; Gonadotropins | 2005 |
A randomized controlled trial evaluating metformin pre-treatment and co-administration in non-obese insulin-resistant women with polycystic ovary syndrome treated with controlled ovarian stimulation plus timed intercourse or intrauterine insemination.
Topics: Adult; Area Under Curve; Chorionic Gonadotropin; Female; Follicle Stimulating Hormone; Gonadotropins | 2005 |
A randomized controlled trial evaluating metformin pre-treatment and co-administration in non-obese insulin-resistant women with polycystic ovary syndrome treated with controlled ovarian stimulation plus timed intercourse or intrauterine insemination.
Topics: Adult; Area Under Curve; Chorionic Gonadotropin; Female; Follicle Stimulating Hormone; Gonadotropins | 2005 |
A randomized controlled trial evaluating metformin pre-treatment and co-administration in non-obese insulin-resistant women with polycystic ovary syndrome treated with controlled ovarian stimulation plus timed intercourse or intrauterine insemination.
Topics: Adult; Area Under Curve; Chorionic Gonadotropin; Female; Follicle Stimulating Hormone; Gonadotropins | 2005 |
A randomized controlled trial evaluating metformin pre-treatment and co-administration in non-obese insulin-resistant women with polycystic ovary syndrome treated with controlled ovarian stimulation plus timed intercourse or intrauterine insemination.
Topics: Adult; Area Under Curve; Chorionic Gonadotropin; Female; Follicle Stimulating Hormone; Gonadotropins | 2005 |
A randomized controlled trial evaluating metformin pre-treatment and co-administration in non-obese insulin-resistant women with polycystic ovary syndrome treated with controlled ovarian stimulation plus timed intercourse or intrauterine insemination.
Topics: Adult; Area Under Curve; Chorionic Gonadotropin; Female; Follicle Stimulating Hormone; Gonadotropins | 2005 |
A randomized controlled trial evaluating metformin pre-treatment and co-administration in non-obese insulin-resistant women with polycystic ovary syndrome treated with controlled ovarian stimulation plus timed intercourse or intrauterine insemination.
Topics: Adult; Area Under Curve; Chorionic Gonadotropin; Female; Follicle Stimulating Hormone; Gonadotropins | 2005 |
Efficacy of combined metformin-letrozole in comparison with metformin-clomiphene citrate in clomiphene-resistant infertile women with polycystic ovarian disease.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Resistance; Drug Therapy, Combination; Endometrium; Fe | 2006 |
No more surrogate end-points in randomised trials: the PCOSMIC trial protocol for women with polycystic ovary syndrome using metformin for infertility with clomiphene.
Topics: Adult; Clomiphene; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedu | 2006 |
Gonadotropin-releasing hormone antagonist and metformin for treatment of polycystic ovary syndrome patients undergoing in vitro fertilization-embryo transfer.
Topics: Chorionic Gonadotropin; Estradiol; Female; Fertilization in Vitro; Follicle Stimulating Hormone; Gon | 2006 |
Use of metformin for prevention of ovarian hyperstimulation syndrome: a novel approach.
Topics: Adult; Drug Therapy, Combination; Embryo Transfer; Estrogens; Female; Follicle Stimulating Hormone; | 2006 |
The Pregnancy in Polycystic Ovary Syndrome study: baseline characteristics of the randomized cohort including racial effects.
Topics: Adolescent; Adult; Age Distribution; Clomiphene; Double-Blind Method; Drug Combinations; Female; Fer | 2006 |
Effects of metformin and clomiphene citrate on ovarian vascularity in patients with polycystic ovary syndrome.
Topics: Adult; Blood Flow Velocity; Clomiphene; Cohort Studies; Female; Humans; Infertility, Female; Metform | 2006 |
Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction and achievement of pregnancy in 154 women with polycystic ovary syndrome.
Topics: Adult; Canada; Clomiphene; Comorbidity; Drug Combinations; Female; Fertility Agents, Female; Humans; | 2007 |
Increase of multiple pregnancies caused by ovulation induction with gonadotropin in combination with metformin in infertile women with polycystic ovary syndrome.
Topics: Adult; Drug Therapy, Combination; Female; Gonadotropins; Humans; Infertility, Female; Metformin; Pol | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
Topics: Adult; Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2007 |
C-reactive protein levels are unaffected by metformin during pretreatment and an IVF cycle in women with polycystic ovary syndrome.
Topics: Adult; Androgens; Biomarkers; Body Mass Index; C-Peptide; C-Reactive Protein; Double-Blind Method; F | 2008 |
Clomiphene citrate versus metformin as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome.
Topics: Adult; Anovulation; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Menst | 2007 |
Clomiphene citrate versus metformin as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome.
Topics: Adult; Anovulation; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Menst | 2007 |
Clomiphene citrate versus metformin as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome.
Topics: Adult; Anovulation; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Menst | 2007 |
Clomiphene citrate versus metformin as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome.
Topics: Adult; Anovulation; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Menst | 2007 |
Clomiphene citrate versus metformin as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome.
Topics: Adult; Anovulation; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Menst | 2007 |
Clomiphene citrate versus metformin as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome.
Topics: Adult; Anovulation; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Menst | 2007 |
Clomiphene citrate versus metformin as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome.
Topics: Adult; Anovulation; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Menst | 2007 |
Clomiphene citrate versus metformin as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome.
Topics: Adult; Anovulation; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Menst | 2007 |
Clomiphene citrate versus metformin as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome.
Topics: Adult; Anovulation; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Menst | 2007 |
Effect of metformin pretreatment on pregnancy outcome of in vitro matured oocytes retrieved from women with polycystic ovary syndrome.
Topics: Adult; Female; Fertilization in Vitro; Humans; Hypoglycemic Agents; Infertility, Female; Metformin; | 2008 |
Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial.
Topics: Clomiphene; Community Networks; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; | 2008 |
Possible metformin effect on adrenal androgens during pretreatment and IVF cycle in women with polycystic ovary syndrome.
Topics: Adrenal Glands; Adult; Androgens; Body Mass Index; Chorionic Gonadotropin; Dehydroepiandrosterone Su | 2009 |
Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction, achievement of pregnancy, and live birth in Asian women with polycystic ovary syndrome: a randomized controlled trial.
Topics: Adult; Anovulation; Asian People; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, F | 2009 |
Efficacy predictors for metformin and clomiphene citrate treatment in anovulatory infertile patients with polycystic ovary syndrome.
Topics: Adult; Anovulation; Clomiphene; Estradiol; Female; Fertility Agents; Follicle Stimulating Hormone; H | 2009 |
Does adding metformin to clomifene citrate lead to higher pregnancy rates in a subset of women with polycystic ovary syndrome?
Topics: Adult; Anovulation; Clomiphene; Drug Therapy, Combination; Female; Humans; Infertility, Female; Metf | 2008 |
Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone.
Topics: Adolescent; Adult; Androstenedione; Body Mass Index; Clomiphene; Dehydroepiandrosterone Sulfate; Dou | 2001 |
Insulin resistance in clomiphene responders and non-responders with polycystic ovarian disease and therapeutic effects of metformin.
Topics: Adult; Analysis of Variance; Blood Glucose; Body Mass Index; Clomiphene; Female; Fertility Agents, F | 2001 |
Insulin resistance in clomiphene responders and non-responders with polycystic ovarian disease and therapeutic effects of metformin.
Topics: Adult; Analysis of Variance; Blood Glucose; Body Mass Index; Clomiphene; Female; Fertility Agents, F | 2001 |
Insulin resistance in clomiphene responders and non-responders with polycystic ovarian disease and therapeutic effects of metformin.
Topics: Adult; Analysis of Variance; Blood Glucose; Body Mass Index; Clomiphene; Female; Fertility Agents, F | 2001 |
Insulin resistance in clomiphene responders and non-responders with polycystic ovarian disease and therapeutic effects of metformin.
Topics: Adult; Analysis of Variance; Blood Glucose; Body Mass Index; Clomiphene; Female; Fertility Agents, F | 2001 |
Metformin therapy improves ovulatory rates, cervical scores, and pregnancy rates in clomiphene citrate-resistant women with polycystic ovary syndrome.
Topics: Adult; Clomiphene; Double-Blind Method; Drug Resistance; Female; Fertility Agents, Female; Gonadal S | 2002 |
Metformin does not enhance ovulation induction in clomiphene resistant polycystic ovary syndrome in clinical practice.
Topics: Adult; Clomiphene; Cross-Over Studies; Double-Blind Method; Drug Resistance; Female; Fertility Agent | 2002 |
76 other studies available for metformin and Infertility, Female
| Article | Year |
|---|---|
Comparative Proteomic Analysis Reveals Metformin Improves the Expression of Biomarkers of Endometrial Receptivity in Infertile Women with Minimal/Mild Endometriosis.
Topics: Adult; Animals; Biomarkers; Endometriosis; Endometrium; Female; Humans; Infertility, Female; Metform | 2022 |
The influence of ethnicity on outcomes of ovulation induction with clomifene citrate in women with PCOS.
Topics: Citrates; Clomiphene; Ethnicity; Female; Fertility Agents, Female; Humans; Infertility, Female; Male | 2022 |
The Effects of Letrozole and Metformin Combined with Targeted Nursing Care on Ovarian Function, LH, and FSH in Infertile Patients with Polycystic Ovary Syndrome.
Topics: Female; Follicle Stimulating Hormone; Humans; Infertility, Female; Letrozole; Metformin; Polycystic | 2022 |
At the crossroads of fertility and metabolism: the importance of AMPK-dependent signaling in female infertility associated with hyperandrogenism.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Mullerian Hormone; Biological Phenomena; Female; Fertil | 2022 |
Metformin, clomiphene citrate and flutamide effects on oocyte ultrastructure status and quality in PCOS mouse model.
Topics: Animals; Body Weight; Clomiphene; Female; Fertility Agents, Female; Flutamide; Humans; Infertility, | 2022 |
Impact of Disturbed Glucose Homeostasis Regulated by AMPK in Endometrium on Embryo Implantation in Diabetes Mice.
Topics: Adenylate Kinase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes, Gestational; Em | 2020 |
Successful IVF outcome after repeat laparoscopic ovarian drilling in a case of resistant PCOS.
Topics: Abortion, Habitual; Adult; Female; Fertilization in Vitro; Glucose Metabolism Disorders; Humans; Hyp | 2020 |
The Effects of Altered Endometrial Glucose Homeostasis on Embryo Implantation in Type 2 Diabetic Mice.
Topics: AMP-Activated Protein Kinases; Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; | 2021 |
Metformin Therapy for the Management of Infertility in Women with Polycystic Ovary Syndrome: Scientific Impact Paper No. 13.
Topics: Androgen Antagonists; Female; Humans; Infertility, Female; Insulin Resistance; Metformin; Polycystic | 2017 |
Pregnancy outcome after first-trimester exposure to metformin: A prospective cohort study.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adolescent; Adult; Diabetes Mellitus, Type 2; Fe | 2018 |
Mild ovarian stimulation with letrozole plus fixed dose human menopausal gonadotropin prior to IVF/ICSI for infertile non-obese women with polycystic ovarian syndrome being pre-treated with metformin: a pilot study.
Topics: Adult; Female; Gonadotropins; Humans; Infertility, Female; Letrozole; Metformin; Nitriles; Oocyte Re | 2018 |
Metformin Regulates Key MicroRNAs to Improve Endometrial Receptivity Through Increasing Implantation Marker Gene Expression in Patients with PCOS Undergoing IVF/ICSI.
Topics: Adult; Embryo Implantation; Endometrium; Female; Fertilization in Vitro; Gene Expression; Genetic Ma | 2019 |
Treatment strategies in PCOS patients.
Topics: Clomiphene; Diabetes Mellitus; Diet; Exercise; Female; Fertility Agents, Female; Humans; Hypoglycemi | 2005 |
Ovarian 11β-hydroxysteroid dehydrogenase (11βHSD) activity is suppressed in women with anovulatory polycystic ovary syndrome (PCOS): apparent role for ovarian androgens.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Adult; Androgens; Anovulation; Cortisone; Dose-Response Relat | 2013 |
Alterations in thyroid function among the different polycystic ovary syndrome phenotypes.
Topics: Adult; Body Mass Index; Drug Therapy, Combination; Female; Hospitals, University; Humans; Hypoglycem | 2013 |
Infertility treatment in polycystic ovary syndrome: lifestyle interventions, medications and surgery.
Topics: Clomiphene; Exercise; Female; Fertilization in Vitro; Humans; Infertility, Female; Life Style; Metfo | 2013 |
Treatment of polycystic ovarian syndrome with insulin resistance by insulin-sensitizer.
Topics: Adolescent; Adult; Blood Glucose; Body Mass Index; C-Reactive Protein; Cholesterol, HDL; Cholesterol | 2014 |
Gestational diabetes mellitus risk factors in women with polycystic ovary syndrome (PCOS).
Topics: Adult; Cross-Sectional Studies; Diabetes, Gestational; Female; Fertilization; Humans; Hypoglycemic A | 2014 |
Polycystic ovaries and obesity.
Topics: Adipokines; Adiponectin; Female; Humans; Hyperandrogenism; Hyperinsulinism; Hypoglycemic Agents; Inf | 2015 |
British Fertility Society Policy and Practice Committee: adjuvants in IVF: evidence for good clinical practice.
Topics: Chemotherapy, Adjuvant; Evidence-Based Medicine; Female; Fertility; Fertilization in Vitro; Humans; | 2015 |
Diagnosis and Treatment of Polycystic Ovary Syndrome.
Topics: Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Humans; Hyperandrogenism; Hypogl | 2016 |
Should metformin be included in fertility treatment of PCOS patients?
Topics: Adenosine Triphosphate; Diabetes Mellitus, Type 2; Diabetes, Gestational; Electron Transport; Female | 2017 |
Restored Plasma Anandamide and Endometrial Expression of Fatty Acid Amide Hydrolase in Women With Polycystic Ovary Syndrome by the Combination Use of Diane-35 and Metformin.
Topics: Adult; Amidohydrolases; Androgen Antagonists; Arachidonic Acids; Cyproterone Acetate; Drug Combinati | 2017 |
Metformin in the treatment of infertility in polycystic ovarian syndrome: an alternative perspective.
Topics: Clomiphene; Drug Administration Schedule; Drug Therapy, Combination; Female; Fertility Agents, Femal | 2008 |
A reappraisal of the role of polycystic ovary syndrome in recurrent miscarriage.
Topics: Abortion, Habitual; Androgens; Anovulation; Female; Gonadotropins; Humans; Infertility, Female; Insu | 2008 |
Efficacy of metformin supplementation during ovarian stimulation of lean PCOS patients undergoing in vitro fertilization.
Topics: Adult; Blood Glucose; Body Mass Index; Case-Control Studies; Chorionic Gonadotropin; Dinoprostone; E | 2009 |
Is metformin beneficial for the treatment of infertility in women with PCOS?
Topics: Adult; Female; Humans; Hypoglycemic Agents; Infertility, Female; Metformin; Polycystic Ovary Syndrom | 2009 |
Investigating infertility.
Topics: Antineoplastic Agents; Dermoid Cyst; Female; Humans; Infertility, Female; Medical History Taking; Me | 2009 |
Androgen excess in women: not just a cosmetic problem.
Topics: Adrenal Hyperplasia, Congenital; Androgen Antagonists; Androgens; Female; Hirsutism; Humans; Hyperan | 2010 |
Reproductive endocrinology: live birth prediction in polycystic ovary syndrome.
Topics: Adult; Clomiphene; Female; Humans; Hypoglycemic Agents; Infertility, Female; Live Birth; Metformin; | 2010 |
Effects of oral contraceptives and metformin on the outcome of in vitro maturation in infertile women with polycystic ovary syndrome.
Topics: Adult; Contraceptives, Oral; Female; Fertilization in Vitro; Humans; In Vitro Oocyte Maturation Tech | 2010 |
Effects of metformin administration on plasma gonadotropin levels in women with infertility, with an in vitro study of the direct effects on the pituitary gonadotrophs.
Topics: Adult; Cell Line; Female; Follicle Stimulating Hormone; Gonadotrophs; Gonadotropin-Releasing Hormone | 2010 |
[Diagnosis and treatment of polycystic ovary syndrome].
Topics: Acne Vulgaris; Alopecia; Amenorrhea; Androgens; Clomiphene; Diabetes Complications; Diagnosis, Diffe | 2010 |
Decision trees for identifying predictors of treatment effectiveness in clinical trials and its application to ovulation in a study of women with polycystic ovary syndrome.
Topics: Age Factors; Androgens; Anovulation; Body Mass Index; Clomiphene; Decision Trees; Drug Therapy, Comb | 2010 |
Ovulation induction in polycystic ovary syndrome: No. 242, May 2010.
Topics: Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Fertilization in Vitro; Gonadotr | 2010 |
Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study.
Topics: Abdominal Pain; Adult; Cohort Studies; Diabetes, Gestational; Egypt; Female; Fertilization in Vitro; | 2011 |
Early onset and high prevalence of gestational diabetes in PCOS and insulin resistant women before and after assisted reproduction.
Topics: Adult; Age of Onset; Cohort Studies; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Inf | 2011 |
Metformin as adjuvant therapy to IVF in women with PCOS: when is intention-to-treat unintentional?
Topics: Female; Humans; Infertility, Female; Metformin; Polycystic Ovary Syndrome; Pregnancy | 2011 |
Analysis of factors predicting success of metformin and clomiphene treatment for women with infertility owing to PCOS-related ovulation dysfunction in a randomised controlled trial.
Topics: Anovulation; Body Mass Index; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Fem | 2011 |
Metformin administration in patients with polycystic ovary syndrome who receive gonadotropins for in vitro fertilization cycles: 10-year experience in a large infertile population.
Topics: Adult; Cohort Studies; Female; Fertility Agents, Female; Fertilization in Vitro; Gonadotropins; Huma | 2012 |
[Use of insulin sensitizers in the treatment of infertility in patients with polycystic ovary syndrome (POS)].
Topics: Female; Humans; Hypoglycemic Agents; Infertility, Female; Insulin Resistance; Metformin; Polycystic | 2012 |
Reproductive endocrinology: Infertility treatment in PCOS--is metformin in from the cold?
Topics: Comorbidity; Female; Humans; Infertility, Female; Metformin; Obesity; Polycystic Ovary Syndrome; Tre | 2012 |
Prevalence, trends, and patterns of use of antidiabetic medications among pregnant women, 2001-2007.
Topics: Adolescent; Adult; Child; Diabetes, Gestational; Female; Humans; Hyperglycemia; Hypoglycemic Agents; | 2013 |
Anti-Műllerian hormone--a prognostic marker for metformin therapy efficiency in the treatment of women with infertility and polycystic ovary syndrome.
Topics: Anti-Mullerian Hormone; Biomarkers; Female; Humans; Infertility, Female; Metformin; Polycystic Ovary | 2012 |
Clomid versus metformin for ovulation induction--let's not have any "hanging chads"!
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Metformin; Ovulation Indu | 2002 |
Metformin and BMI?
Topics: Body Mass Index; Female; Humans; Infertility, Female; Metformin; Ovulation Induction; Polycystic Ova | 2002 |
The treatment of polycystic ovary syndrome.
Topics: Adult; Androgen Antagonists; Cabergoline; Cardiovascular Diseases; Clomiphene; Cyproterone Acetate; | 2004 |
Surgical treatment of polycystic ovary syndrome associated with infertility.
Topics: Clomiphene; Female; Gonadotropins; Gynecologic Surgical Procedures; Humans; Hyperandrogenism; Infert | 2004 |
Women with polycystic ovary syndrome (PCOS) often undergo protracted treatment with metformin and are disinclined to stop: indications for a change in licensing arrangements?
Topics: Clinical Trials as Topic; Female; Humans; Infertility, Female; Metformin; Patient Participation; Pat | 2004 |
Are laparoscopic ovarian diathermy and gonadotropin administration the only therapeutic second-steps in clomiphene-citrate resistant women with polycystic ovary syndrome?
Topics: Clomiphene; Electrocoagulation; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Gona | 2004 |
Efficacy of metformin on ovulation induction in Asian women with polycystic ovary syndrome.
Topics: Adult; Androstenedione; Body Mass Index; Clomiphene; Coitus; Female; Humans; Hypoglycemic Agents; In | 2004 |
Metformin: an advance in ovulation induction.
Topics: Adult; Anovulation; Clomiphene; Female; Fertility Agents, Female; Humans; Hypoglycemic Agents; Infer | 2005 |
Metformin in the treatment of clomiphene citrate-resistant women with high BMI and primary infertility: clinical results and reproductive outcome.
Topics: Adult; Body Mass Index; Clomiphene; Drug Resistance; Female; Humans; Hypoglycemic Agents; Infertilit | 2005 |
Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin.
Topics: Adolescent; Adult; Female; Humans; Infant, Newborn; Infertility, Female; Male; Metformin; Polycystic | 2006 |
Drugs for anovulatory infertility in polycystic ovary syndrome.
Topics: Anovulation; Clomiphene; Drug Resistance; Female; Fertility Agents, Female; Humans; Infertility, Fem | 2006 |
[Clinical analysis of 4 treatments for woman polycystic ovarian syndrome with infertility].
Topics: Adult; Chorionic Gonadotropin; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Fema | 2006 |
Metformin and early pregnancy?
Topics: Adolescent; Adult; Female; Humans; Infant, Newborn; Infertility, Female; Male; Metformin; Polycystic | 2006 |
Ovarian stockpiling in polycystic ovary syndrome, infertility, and the combined use of rosiglitazone and metformin.
Topics: Adult; Diabetes Mellitus, Type 2; Female; Humans; Infertility, Female; Metformin; Polycystic Ovary S | 2006 |
Treating the polycystic ovary syndrome the old-fashioned way.
Topics: Birth Rate; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; Hypogly | 2007 |
Ovulation induction management of PCOS.
Topics: Aromatase Inhibitors; Clomiphene; Endometrial Neoplasms; Female; Fertility Agents, Female; Glucocort | 2007 |
Pregnancy considerations in women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2007 |
Treatment of infertility in the polycystic ovary syndrome.
Topics: Clomiphene; Diarrhea; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; Hypoglyce | 2007 |
Treatment of infertility in the polycystic ovary syndrome.
Topics: Delayed-Action Preparations; Female; Humans; Hypoglycemic Agents; Infertility, Female; Live Birth; M | 2007 |
Controlled natural cycle IVF: a novel approach for a dominant follicle during an in-vitro maturation cycle.
Topics: Adult; Female; Humans; Hypoglycemic Agents; Infertility, Female; Metformin; Ovarian Follicle; Polycy | 2007 |
What is the best first-step therapeutic approach in treating anovulatory infertility in patients with polycystic ovary syndrome? Questions that are still unanswered.
Topics: Anovulation; Clomiphene; Female; Fertility Agents, Female; Humans; Hypoglycemic Agents; Infertility, | 2007 |
[Polycystic ovary syndrome (PCOS)].
Topics: Drug Therapy, Combination; Family Practice; Female; Humans; Hyperinsulinism; Hypoglycemic Agents; In | 2007 |
Clomiphene versus metformin for ovulation induction in polycystic ovary syndrome: the winner is ....
Topics: Body Mass Index; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Metformi | 2007 |
Risk of multiple gestation after ovulation induction in polycystic ovary syndrome.
Topics: Adult; Clomiphene; Female; Fertility Agents, Female; Gonadotropins; Humans; Infertility, Female; Met | 2007 |
Consensus on infertility treatment related to polycystic ovary syndrome.
Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone | 2008 |
Consensus on infertility treatment related to polycystic ovary syndrome.
Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone | 2008 |
Consensus on infertility treatment related to polycystic ovary syndrome.
Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone | 2008 |
Consensus on infertility treatment related to polycystic ovary syndrome.
Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone | 2008 |
Consensus on infertility treatment related to polycystic ovary syndrome.
Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone | 2008 |
Consensus on infertility treatment related to polycystic ovary syndrome.
Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone | 2008 |
Consensus on infertility treatment related to polycystic ovary syndrome.
Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone | 2008 |
Consensus on infertility treatment related to polycystic ovary syndrome.
Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone | 2008 |
Consensus on infertility treatment related to polycystic ovary syndrome.
Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone | 2008 |
Consensus on infertility treatment related to polycystic ovary syndrome.
Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone | 2008 |
Consensus on infertility treatment related to polycystic ovary syndrome.
Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone | 2008 |
Consensus on infertility treatment related to polycystic ovary syndrome.
Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone | 2008 |
Consensus on infertility treatment related to polycystic ovary syndrome.
Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone | 2008 |
Consensus on infertility treatment related to polycystic ovary syndrome.
Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone | 2008 |
Consensus on infertility treatment related to polycystic ovary syndrome.
Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone | 2008 |
Consensus on infertility treatment related to polycystic ovary syndrome.
Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone | 2008 |
The use of metformin as first line treatment in polycystic ovary syndrome.
Topics: Adolescent; Adult; Amenorrhea; Body Mass Index; Clomiphene; Female; Follicle Stimulating Hormone; Hi | 2008 |
Administration of metformin to a diabetic woman with extreme hyperandrogenemia of nontumoral origin: management of infertility and prevention of inadvertent masculinization of a female fetus.
Topics: Adult; Diabetes Mellitus, Type 1; Disorders of Sex Development; Female; Humans; Hyperandrogenism; Hy | 1999 |
Insulin sensitizers and polycystic ovary syndrome: can a diabetes medication treat infertility?
Topics: Female; Humans; Hypoglycemic Agents; Infertility, Female; Insulin; Metformin; Polycystic Ovary Syndr | 2000 |
Association of metformin and pregnancy in the polycystic ovary syndrome. A report of three cases.
Topics: Adult; Female; Humans; Hypoglycemic Agents; Infertility, Female; Insulin Resistance; Metformin; Poly | 2000 |
Polycystic ovary syndrome, infertility, familial thrombophilia, familial hypofibrinolysis, recurrent loss of in vitro fertilized embryos, and miscarriage.
Topics: Abortion, Habitual; Adult; Amenorrhea; Androstenedione; Embryo Transfer; Female; Fertilization in Vi | 2000 |
Metformin improves ovulation and pregnancy rates in patients with polycystic ovary syndrome.
Topics: Adult; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Metformin; Ovulati | 2001 |
Pregnancies following use of metformin for ovulation induction in patients with polycystic ovary syndrome.
Topics: Adult; Anovulation; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Metfo | 2002 |